CN103520302B - Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof - Google Patents
Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health care medicine, specifically to an anti-fatigue capsule with a sea-buckthorn leaf or an extract thereof as a main raw material and a preparation method thereof. To overcome a technical problem, the invention provides an anti-fatigue health-care capsule with the sea-buckthorn leaf as a main raw material and a preparation method thereof. According to a technical scheme provided by the invention, the sea-buckthorn leaf anti-fatigue capsule comprises the following raw materials by mass: 500 to 550 parts of the sea-buckthorn leaf, 180 to 200 parts of rhodiola root, 100 to 150 parts of prepared fleece flower root, 80 to 100 parts of dogwood, 60 to 80 parts of milkvetch root, 40 to 60 parts of eucommia bark, 50 to 60 parts of epimedium, 40 to 60 parts of tree peony bark, 30 to 40 parts of ginseng and 20 to 30 parts of calcium gluconate. The above-mentioned raw materials undergo crushing, extraction, freeze drying, mixing, granulation, drying, sterilization and capsule filling so as to prepare a finished anti-fatigue capsule product.
Description
Technical field
The present invention relates to health care medicine, be specifically related to a kind of with Folium Hippophae or its extract antifatigue capsule that is main material and preparation method thereof.
Background technology
Fatigue is human body spirit and muscle power obviously sensation tired out and unconformable, and its clinical manifestation is commonly encountered diseases, frequently-occurring disease, is anosis or little pathogenetic omen and increase the weight of.Fatigue can be excessive because of mental work, and especially elderly knowledge technology is key; Also can be excessive because of physical work, the especially shop floor worker such as railway, Gong Lu, municipal administration, modernization real estate market building; The long-term work of office clan and overtime work; Long-term does not have enough sleep; Momental minimizing; Bad living habit, as smoked and drink, the place amusement such as long-term KTV; Diet is irregular, fat-reducing is cultivated one's moral character, malnutrition, have a delicate constitution, cause energy produce not enough, overrun; Long-term sorrow is pondered over, and neural excitation is excessively strong, long, and thinking is nervous, causes cerebral anoxia and produces neuroinidia and tired; The work rhythm and pace of moving things is accelerated, and pressure is excessive, grueling warfare, hyperkinesia, and physical demands is excessive, and muscle lactate and metabolite overheap thereof, cause muscle tone to decline, and exercise endurance reduces, and energy expenditure too much produces tired; High altitude anoxia district work etc. all can cause out short-term, irregular or long-term fatigue phenomenon; Weak, prolonged illness, sap one's vitality, negative and positive of qi and blood metabolic imbalance etc. all can produce fatigue.Therefore, fatigue is the general performance of subhealth state and morbid state.
In fact, numerous disease, as tinnitus, dizzy, forgetful, cardiopalmus, insomnia, menoxenia, drowsiness, fear of cold, weakness of the lower extremities, climacteric syndrome, hypoimmunity, computer air conditioner comprehensive is levied, blood deficiency, the deficiency of vital energy, the deficiency of YIN, yang deficiency, hypertension, coronary heart disease, hyperlipidemia, fatty liver, diabetes, gastric ulcer, chronic gastritis, viral hepatitis, chronic cholecystitis, asthma, chronic bronchitis, chronic pulmonary heart disease, congestive heart failure, thrombophlebitis, senile dementia disease, depression, obesity, trimester of pregnancy, vaginitis, uterine prolapse, rheumatoid, renal failure, weakness of the lower extremities, vasculitis, varicosis, cancer middle and late stage etc., have in various degree show feeling of fatigue.
Can not adjust in time if tired, treat, then the pathological changes of a series of nerve, endocrine, immunity and internal organs makings can occur.In addition, can there is fatigue in various degree to certain phase in every disease progression, increases the weight of development and the deterioration of the state of an illness.Therefore attention prevents, alleviates, treats all measures that can cause tired generation, as healthy thinking, strike a proper balance between work and rest, fully rest, nourishing healthy, environmental health, suitably take exercise, appropriateness builds up one's health by taking tonic, be all eliminate subhealth state, prevent disease, the effective measures of relieving fatigue.
Modern Chinese medicine is thought, fatigue is that consumption hinders the deficiency syndrome of vigour, is that spirit is unbalance, caused by the smooth double factor of psychology.There are its cause of disease, pathogenesis, are a kind of chronic synthetic disease, are mostly attributed to subhealth state category.Chase after its root, they all relate to the vital organs of the human body, and mainly brain (nerve), spleen, liver, stomach, kidney are main.By conditioning will, tired calming the nerves of dispelling, brain-strengthening oxygenating, tonify deficiency righting, nourishes the methods such as primordial QI reinforcing, the object reach prevention, controlling and treat.
Maintaining healthy be to keep psychology and physiological balance and health for a long time at all.Stablize and keep good phychology emotion, form good living habit, strike a proper balance between work and rest, meat and vegetables collocation balance, absorbs water fruit vegetable more, strengthens taking exercise, improves self body constitution and immunocompetence.
Fructus Hippophae administers desertification, desertification, barren deserted mountain, barren hill in the world, classic pioneer's economic tree at present.In long-term and natural harsh and unforgiving environments are struggled against, its fruit, stem and leaf have accumulated a large amount of nutrition and degeneration-resistant border allelochemical, except not containing V
doutward, containing all other natural complex, and quantity is maximum; Containing 8 seed amino acids of high protein and needed by human, rich content, reasonable mixture ratio; High containing unsaturated fatty acid (linoleic acid, linolenic acid) quantity, proportioning the best (1:0.9) physiology, pharmacological function are obvious; Containing multiple polyphenoils, as tea polyphenols, catechin, flavone, polyphenol, beta-carotene, triterpene, sterol, serotonin etc., higher than other plant; The major function of fruit, stem and leaf is: energy blood circulation promoting and blood stasis dispelling, soothing liver and strengthening spleen, relieving cough and asthma, the antibacterial granulation promoting of antiinflammatory, resisting fatigue, raising immunity, Guben Baoyuan, Radix Stephaniae Tetrandrae is sick, preventive treatment of disease, effectively can correct subhealth state, and have significant prevention, therapeutic effect to various diseases.In the medicine of Tibet, lama claims Fructus Hippophae to be " miraculous cure ", " holy fruit " that be guaranteed to cure all diseases.Therefore, Fructus Hippophae is medicinal main based on Fructus Hippophae, Folium Hippophae, juice of Fructus Hippophae, Fructus Hippophae flavone, Oleum Hippophae.Modern Fructus Hippophae health drink is also primary raw material mainly with Fructus Hippophae.The utilization of Folium Hippophae is limited to making hippophae rhamnoides tea at present substantially, but finds in the clinical and pharmacological testing of nearly more than 10 years, the effective ingredient contained by it and function, much larger than Fructus Hippophae, is the important source material of Fructus Hippophae food, department of health, drug research and development from now on.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, and it take Folium Hippophae as the anti-fatigue health-caring capsule of primary raw material and the method for preparation that technical problem to be solved is to provide a kind of.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 500-550 part, Radix Rhodiolae 180-200 part, Radix Polygoni Multiflori Preparata 100-150 part, Fructus Corni 80-100 part, Radix Astragali 60-80 part, Cortex Eucommiae 40-60 part, Herba Epimedii 50-60 part, Cortex Moutan 40-60 part, Radix Ginseng 30-40 part, calcium gluconate 20-30 part.
The preparation method of above-mentioned sea-buckthorn leaf anti-fatigue capsule, comprise the following steps: by 9 of described mass distribution ratio kinds of herbal raw materials through roguing all in advance, dust removal, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:15-25 soaks 1-1.5h, then, under temperature 60 C, 2-4h is extracted continuously; By extracting solution after filtration, concentrated, drying obtains herbal raw material elite extract, and then compare compatibility by prescription quality, described herbal raw material elite extract is mixed homogeneously with described calcium gluconate, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
As preferred a kind of sea-buckthorn leaf anti-fatigue capsule, herbal raw material Folium Hippophae in described raw material, Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Corni, the Radix Astragali, the Cortex Eucommiae, Herba Epimedii, Cortex Moutan, Radix Ginseng all directly adopt the extract side of entering, and by extract weight, that is:
Folium Hippophae extract 500-550 part, Radix Rhodiolae extract 180-200 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Fructus Corni extract 80-100 part, Radix Astragali extract 60-80 part, Cortex Eucommiae extract 40-60 part, Herba Epimedii extract 50-60 part, Cortex Moutan extract 40-60 part, Radix Ginseng extract 30-40 part, calcium gluconate 20-30 part.
The preparation method of above-mentioned sea-buckthorn leaf anti-fatigue capsule, comprise the following steps: respectively by the decoction pieces of described 9 kinds of herbal raw materials through roguing, dust removal, pulverizing, material after pulverizing is adopted the edible ethanol material in mass ratio of 80%: solvent=1:15-25 soaks 1-1.5h, then, at temperature 50-65 DEG C, 2-4h is extracted continuously; By extracting solution after filtration, concentrated, dry, obtain 9 kinds of herbal raw material extracts; Press prescription mass ratio again, described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtain sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
In order to improve extraction efficiency and precision and better protect effective ingredient not make it to run off, the present invention has also done following optimization to above-mentioned preparation method:
The optimum condition of described continuous extraction is the ultrasound wave, mechanical agitation 120 revs/min, the air compressor machine airflow stirring that load 3kw power;
Described extracting liquid filtering method preferably adopts duplex strainer to filter;
Extracting solution after described filtration is concentrated into quality than solid content through vacuum diaphragm: solvent=1:2-3, then through frozen drying powdered, obtains herbal raw material elite extract.
One, design principle of the present invention:
Fatigue is the general performance of the subhealth state that causes of many reasons and morbid state, produce tired basic reason, that internal and external factor causes the koinomatter metabolism between viscera, energy metabolism, Information Conduction to lose balance, create disorder, and then make adjustment human body essence, gas, god, type nerve-endocrine-immunological network lose balance, show following aspect:
Deficiency of kidney-essence---can not activating QI hemopoietic, metal fatigue, soreness of the waist and knees;
Depression of liver-QI---the liver failing to maintain the normal flow of QI, causes depressed emotion, loss of appetite, menoxenia, dysmenorrhea, amenorrhea, weak;
Stagnation of dampness due to deficiency of the spleen---insufficiency of generating and transforming QI and blood, neurolysis, heaviness of the head and fatigue of the body, fatigue and weak;
Asthenia of both the spleen and kidney---the sun of damage spleen kidney, cause essence tired drowsy, body is tired weak, deficiency of QI with disinclination to talk:
Deficiency of both the heart and spleen---because of eating and drinking without temperance, work with one's mind and excessively, secretly consume cloudy blood, cause deficiency of heart-blood, insomnia and dreamful sleep, shortness of breath and fatigue;
Deficiency of qi and blood---congenital defect, prolonged illness is consumed, and old consumption wound, causes not resistance to work, palpitation and short breath, smart tired power;
Disarmony between the heart and kidney---prolonged illness asthenia, sexual strain, palpitation with fear insomnia, dizzy tinnitus, soreness of the waist and knees.
For this reason, main direction of the present invention is: primordial QI reinforcing mends essence, blood-enriching qi-invigorating, tonify deficiency righting, tired calming the nerves of dispelling.And as target, through repeatedly probing into and test, determine above-mentioned prescription.
Two, prescription element pharmacology of the present invention is introduced and is resolved with compatibility:
1, compatibility is resolved
Monarch drug----Folium Hippophae;
Ministerial drug---Radix Rhodiolae, Radix Polygoni Multiflori Preparata;
Adjuvant drug---Fructus Corni, the Radix Astragali, Herba Epimedii, Radix Ginseng, the Cortex Eucommiae;
Make medicine---Cortex Moutan, calcium gluconate.
The function of each component of above-mentioned prescription is:
Folium Hippophae: strengthening the body resistance, spleen-invigorating stomach-protecting, protects the liver kidney tonifying, carries gas tonify deficiency, resisting fatigue, improves immunity;
Radix Rhodiolae: excitor nerve, allaying tiredness, kidney-replenishing blood-nourishing, blood circulation promoting and blood stasis dispelling;
Radix Polygoni Multiflori Preparata: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening;
Fructus Corni: YIN nourishing, anoxia enduring, resisting fatigue, raising stress ability, prevent and treat osteoporosis, improve immunity;
The Radix Astragali: carry that superficies-consolidating, arresting sweating are admittedly de-, blood pressure lowering, enhancing immunity, protect the liver antiviral, resisting fatigue;
Herba Epimedii: tonifying YANG, the kidney invigorating, bone and muscle strengthening, wind-damp dispelling;
Radix Ginseng: invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, nourishing blood to promote the production of body fluid;
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, hypertension and hyperlipemia, protection cardiovascular, prevention of obesity, antiinflammatory antiviral, enhancing immunity, slow down aging, resisting fatigue;
Cortex Moutan: regulate nerve, taste, liver and gall, kidney, coordinating the actions of various ingredients in a prescription, to reach internal organs, reaches tired calming the nerves of dispelling, brain-strengthening oxygenating, the effect of tonify deficiency righting;
Calcium gluconate: replenish the calcium, antiallergic, convulsions, adjustment metabolic balance, correct some drugs poisoning.
2, prescription component pharmacology and effect
(1) Fructus Hippophae: Fructus Hippophae system covers, Tibetan's medicinal herbs most in use, and the history of existing more than several thousand, is put into the Pharmacopoeia of the People's Republic of China in 1977 years.Its function is eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.For cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, blood stasis amenorrhea, falls the effect of flutterring congestive edema.
Modern science research shows, Folium Hippophae, Fructus Hippophae, seed of Fructus Hippophae all do not have overt toxicity, and acute toxicity test shows, the LD of oral Fructus Hippophae water extract
50be greater than 10g/kg body weight, belong to the food without genotoxic potential.Fructus Hippophae rich in proteins and aminoacid, unsaturated fatty acid, mineral, trace element, vitamin (remove not containing V
doutward, it is containing all vitamin (therefore claiming vitamin plant).Its growth of what is more important is at the extremely frigid zones of height above sea level 800-4000m, and under the condition that large dust storm, intense light irradiation, ultraviolet, high temperature difference (-50 ~ 50 DEG C), serious water shortage, few fertilizer, disease and pest etc. are harsh, it has been survived more than 200,000,000 year.In order to adapt to living environment, a large amount of resistance compound of cylinder accumulation, as physiology, pharmaceutically active compounds such as organic acid, flavonoid, tea polyphenols, catechin, polyphenol, terpenoid, steroid class, beta-carotene, procyanidin, serotonins.Have and promote that growth in humans grows, raising IQ, raising immunologic function, blood fat reducing, blood pressure lowering..Blood sugar lowering also prevents diabetes and the generation of complication.Significant protective effect is had to spleen, stomach, liver, kidney, cardiovascular and cerebrovascular vessel.Accelerate gastric emptying speed, strengthens duodenal contractility intensity.There is relieving constipation, promote enterokinesia effect.Improve calcium, phosphorus utilization, improve the effect of strengthening sclerotin.Bacteriostasis.Radioprotective, antioxidation removes O2
-, HO
-, O2 free radical ability.There is short lead-eliminating effect.Have antalgic and inflammation relieving and strengthen hypoxia-bearing capability and anti-fatigue ability, anti-cerebral anoxia, improves Na+-K+-ATP enzyme in its cerebral tissue, Ca2+-ATP enzymatic activity, reduces LD content.Anti-aging effects.In addition, Fructus Hippophae also has significant tumor killing effect, to the tumour inhibiting rate of solid tumor mice up to 46 ~ 58%, mainly enhances the immunologic function of mice, improves spleen index and thymus index.
In a word, the Fructus Hippophae property of medicine is gentle, strengthening the body resistance, carry gas tonify deficiency, resisting fatigue, improve immunity, with deficiency tonifying kind medicine compatibility, be all a kind of positive adjustment, nourishing function effect to spleen, liver, lung, kidney, the heart, nerve, in the sequence of world's health product, occupy the 2nd, it is the raw material that a kind of medicine-food two-purpose health preserving of preciousness is cured a disease.
(2) Radix Rhodiolae: Radix Rhodiolae is called " plateau Radix Ginseng ", and its main chemical compositions has rhodioside, butyl alcohol and Radix Rhodiolae polysaccharide, and containing flavone compound, phenolic compound, protein, fat, trace volatile oil and trace element, aminoacid etc.Growth is at height above sea level 800---the rare wild plant in 2500 meters of high and cold pollution-free areas.Because its growing environment is severe, as anoxia, low temperature, drying, blast, by ultraviolet radiation, day and night temperature greatly, thus there is very strong vitality and special adaptability.For the traditional medicine that Asia is conventional, there is excitor nerve system, increase the effects such as work efficiency, allaying tiredness and prevention high mountain disease.Shennong's Herbal is pointed out, Radix Rhodiolae is made light of one's life by commiting suicide QI invigorating, does not always prolong life, nontoxic many clothes, and clothes of a specified duration are not hurted sb.'s feelings, can the kidney invigorating, regulates the flow of vital energy and nourishes blood, and cures mainly the whole body weak, uncomfortable in chest etc., also has promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic and effect under leukorrhagia stopping.Tibetan medicine's Four-Volume Medical Code is recorded, Radix Rhodiolae " flat, the puckery of property, kind lung moistening, can the kidney invigorating, regulate the flow of vital energy and nourish blood, cure mainly the diseases such as the whole body is weak, uncomfortable in chest, nauseating, body is empty." Jingzhubencao " is sayed, " Radix Rhodiolae is invigorated blood circulation, and lung heat clearing, cough-relieving are brought down a fever, pain relieving, be used for the treatment of pneumonia, tracheitis, physical weakness, malaise, uncomfortable in chest, be difficult to breathe freely, lip and the palm of the hand blue ".Compendium of Material Medica is recorded " Radix Rhodiolae, eliminating evil bad odor mend various symptoms and signs of deficiency " is " in known tonic, institute is rare "." acid of Herba hylotelephii erythrosticti bitter in the mouth is flat, nontoxic for supplement to Thousand Golden Prescriptions speech.Main large hot large carbuncle(disease), fever of the body is tired of, evil gas, all diseases due to noxious agents produced by various parasites crust arranges, cold and heat migratory arthralgia, various symptoms and signs of deficiency, main woman's whitish metrorrhagia, clear body improving eyesight, and the logical god of clothes is not old for a long time." " modern Practical Chinese medicinal Quality Control Technology ", powder stick is recorded in " Chinese medicine complete works of ": Radix Rhodiolae function with cure mainly: " heat-clearing and toxic substances removing, dampness.For lung-heat, pestilence, limb edema." " Chinese medicine voluminous dictionary " record: Radix Rhodiolae " cold in nature, sweet-puckery flavor.Promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Control hemoptysis, spitting of blood, pneumonia is coughed." " modern practical book on Chinese herbal medicine " say that its effect has " having resisting fatigue, heart tonifying, antiinflammatory, the rising of suppression blood glucose, anti-peroxidation, resisting microwave radiation effect "." Chinese herbal medicine is commonly used in Tibet ": Radix Rhodiolae also has promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic and effect under leukorrhagia stopping.Cure mainly the diseases such as hemoptysis, pneumonia cough, women leucorrhea.Meridian distribution of property and flavor, sweet, bitter, flat; Return lung, heart channel.Function with cure mainly benefiting QI for activating blood circulation, promote blood circulation and relieving asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Modern science research shows, Radix Rhodiolae has strengthening the body resistance, YIN and YANG balance regulating, vigorate qi and replenish the blood, nourishing the brain and improving intelligence, anti-hypoxia, resisting fatigue, two-ways regulation, defying age, radioprotective, nervous system regulation, cardio-cerebrovascular and immunity and antitumor action.
(3) Herba Epimedii: Herba Epimedii is a kind of traditional medicine-food two-purpose tonic, has very high medical value, taste acrid, sweet, warm, returns liver, kidney channel.Cure mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Containing various active chemical compositions such as flavonoid, polysaccharide, volatile oil, lignanoid, trace element, alkaloids.The active component primary efficacy of Herba Epimedii is kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, and waist knee joint flaccidity is soft, cold extremities with aversion to cold, rheumatic arthralgia, numbness contracture, climacteric hypertension.Fructus Corni, Radix Angelicae Sinensis, the Radix Astragali and Radix Ginseng can be joined for suffering from a deficiency of the kidney.Herba Epimedii can improve immunity, increases bone metabolism, improves cardio-cerebrovascular, there is stronger pharmacological action the aspect such as antioxidation, antitumor, gonadotropic Effect.
Recent studies result shows, and Herba Epimedii has good effect in resisting fatigue, raising motor capacity.Herba Epimedii carrys out the restitution of hemopoietic by the exception improving hematopoietic regulation cytokine secretion.Epimedium brevicornum polysaccharide has obvious resisting fatigue, anoxia enduring effect.Epimedium brevicornum polysaccharide is to raising immune effect highly significant.Herba Epimedii total flavones can improve bone density.Total flavones can suppress the loss of castrated rats calcium, phosphorus.Herba Epimedii total flavones has more significant extracorporeal antivirus effect effect.Herba Epimedii can promote hemopoietic function, resists myocardial ischemia, heart failure resistance, arrhythmia, atherosclerosis, blood pressure lowering, antitumor, defying age, immunity moderation and improve effect of bone metabolism, and at antioxidation and improve in hemorheology etc. and have good effect.Icariin and icariside II all have certain scavenging action to hydroxy radical, lipid peroxidation.Herba Epimedii total flavones metabolite has promoting bone growing activity.The compatibilities such as Herba Epimedii and Radix Polygoni Multiflori, Fructus Lycii, Fructus Corni, Herba Cistanches, Radix Rehmanniae Preparata, can treat oligospermatism and azoospermia, clinical efficacy is obvious.Epimedium brevicornum polysaccharide has obvious resisting fatigue, anoxia enduring, has remarkable effect to the prevention of sports fatigue and recovery.
(4) Radix Astragali: Radix Astragali sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.Have that consolidating superficial resistance and supplementing qi, diuretic detumescent, arresting sweating are admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema, enhancing human body immunity function, have and protect the liver, antiviral property myocarditis, strengthen resisting fatigue, antiulcer, antitumor, osteoporosis, diuresis, defying age, anti-stress, blood pressure lowering and effect more antibacterial.In Chinese medicine, the Radix Astragali is QI invigorating good merchantable brand.
Modern science is studied, and the Radix Astragali is evident in efficacy in the insomnia of the kidney invigorating YANG hyperactivity suppressing treatment climacteric.It is definite that Radix Astragali Umbellate Pore Decoction treats intractable membranous nephropathy clinical efficacy.Astragalus polysaccharides has good interior antioxidation action, can slow down aging.The Radix Astragali and Fructus Corni, Herba Epimedii, Radix Salviae Miltiorrhizae compatibility, effective to improving renal failure.The Radix Astragali and Radix Rehmanniae Preparata, Herba Epimedii compatibility, obvious to the effect for the treatment of diabetes osteoporosis.Radix Astragali superfine powder has the function strengthening immunity, resisting fatigue.Astragalus root fermentation liquor through lactic acid bacteria fermentation has resisting fatigue and anti-oxidation health function.Astragaloside has anti-fatigue effect.Radix Astragali aqueous extract can improve the anti-fatigue ability of mice and improve antiradical activities.Compound Radix Astragali polysaccharide equally also has resisting fatigue and resisting oxygen lack.Astragalus polysaccharides can improve mice tolerance to cold at low ambient temperatures, reduces mortality rate, extends mice swimming time, improve anti-fatigue ability, extend mice Hypoxia under normal pressure, improve hypoxia-bearing capability, make serum activity of SOD obviously raise, MDA content obviously reduces simultaneously.The genuine Radix Astragali aqueous extract in Changbai Mountain can by the deposit that increases muscle glycogen and the metabolism slowing down phosphagen to play an antifatigue effect.
(5) Fructus Corni: Fructus Corni is that China commonly uses rare Chinese medicine, sour in the mouth, puckery. slightly warm in nature.Enter liver, kidney two warp.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, has and strengthens immunity, memory reinforcing, antiinflammatory, the effect such as antibacterial.
Recent studies result shows, and Fructus Corni decocting liquid can improve the ability of mice anoxia enduring, resisting fatigue, stress.Cornel kernel water extract also has antifatigue effect.Fructus Corni Aqueous extracts has the osteoporotic effect of control.Fructus Corni significantly can strengthen cellular immunization, the humoral immune function of mice, promotes that mouse thymus is grown and proliferation, and significantly improves the exercise tolerance of mice.
(6) Radix Polygoni Multiflori: Radix Polygoni Multiflori begins to be loaded in < Kaibao Bencao >, for the dried root of polygonum multiflorum thunb, its slightly warm in nature, bitter in the mouth, sweet, puckery. clinical practice have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata not. Radix Polygoni Multiflori can detoxify, eliminating carbuncle, loosening bowel to relieve constipation. cure mainly scrofula infections carbuncle sore, rubella pruritus, dryness of the intestine constipation. the invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, cure mainly blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body is empty.
Modern science result of study shows, and what is first containing anthraquinone component, total sugar, lecithin, psoralen, isopsoralen, two ethylene glycosides, black stilbene glucoside, w-hydroxyemodin, emodin, physcione, normal-butyl-Beta-D-Fructopyranose, Semen Cassiae ketone-8-O-β-D-pyranglucoside etc.
Single Radix Polygoni Multiflori Preparata medicine Contained Serum has the proliferation function stimulating osteoblast cultured in vitro.The effects such as Radix Polygoni Multiflori Preparata has defying age, antibacterial, antiinflammatory, blood fat reducing, blood sugar lowering, protects the liver, neuroprotective.Radix Polygoni Multiflori chrysophanic acid can scavenging hydroxyl.New chemical composition contained in Radix Polygoni Multiflori Preparata is probably the product of maillard reaction, so Radix Polygoni Multiflori Preparata has better nourishing blood function compared with Radix Polygoni Multiflori.According to evaluation principle and the evaluation criteria of medicine pharmacological action, to teenager memory and the pharmacological action of resisting fatigue, document is carried out to Radix Polygoni Multiflori and revalues, with the obvious effect of its hypermnesis clear and definite and resisting fatigue.Radix Polygoni Multiflori can strengthen the ability of mouse anti-reflecting fatigue and anoxia enduring, strengthens the adaptive capacity to hot environment.
(7) Cortex Eucommiae: the Cortex Eucommiae is the distinctive economic plant resources of China, belongs to national two class protective plants.Mainly comprise the chemical compositions such as lignanoids, iridoids, organic acid, gutta-percha, motherland's medical science is thought, Cortex Eucommiae sweet in the mouth, micro-pungent, warm in nature, has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.The Cortex Eucommiae contains the number of chemical compositions such as Phenylpropanoid Glycosides compound, lignin, iridoids, polysaccharide, flavonoid.And there is blood pressure lowering, blood sugar lowering, adjusting blood lipid, anticancer, press down cancer, enhancing immunity, suppress cholesterol rise, anticomplementary activity, mutation, the pharmacological action of the aspects such as antioxidation.The Cortex Eucommiae contains chlorogenic acid, and chlorogenic acid has antiinflammatory, antioxidation, antimutagenic, antiviral, bacteriostasis, prophylaxis of tumours, treatment diabetes and cardiovascular protective effect etc.
The antifatigue effect result of study of Folium Eucommiae extract to exhausted movemeat and recovery mice shows, exhausted movemeat can be improved and SOD, POD activity in return to form lower mouse liver, heart, quadriceps femoris, reduce MDA to generate, show that Cortex Eucommiae extract has antifatigue effect to exhausted movemeat and recovery mice.Modern pharmacological research shows, Folium Eucommiae has blood pressure lowering, adjusting blood lipid, cardiovascular protection, prevention of obesity, antiinflammatory, antiviral, enhancing immunity, slow down aging, fatigue-resisting function. Folium Eucommiae is mainly used in blood pressure lowering, treatment obstetrical and gynecological disease etc. clinically.
(8) Radix Ginseng: Radix Ginseng be have won fame both at home and abroad, rare medicinal herbs that old children all knows.
Radix Ginseng contains more than 30 plants ginsenoside, triterpenoid compound (panoxadiol, panaxatriol), organic acid (citric acid, 1-Hydroxy-1,2,3-propanetricarboxylic acid., Fumaric acid, ketoglutaric acid, malic acid etc.), esters (oleic acid, linoleic acid, triglyceride, Palmic acid), vitamin (vitamin B1, vitamin B2, vitamin B12, vitamin C, nicotinic acid, folic acid, pantothenic acid, biotin and nicotinic acid amide), sterol and glycoside (cupreol, stigmasterol, daucosterol, campesterol, ginsenoside P and ester sterol) etc. thereof.Radix Ginseng sweet in the mouth, micro-hardship, slightly warm in nature, returns spleen, lung, the heart, kidney channel; There is invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, effect of nourishing blood to promote the production of body fluid.Radix Ginseng cures mainly serious disease, prolonged illness, loses blood, takes off vigour caused by liquid for de-, Mental fatigue faint pulse; The lack of appetite asthenia of deficiency of spleen-QI, vomiting is had loose bowels; The dyspnea with shortness of breath of insufficiency of lung-QI, coughs unable; The insomnia and dreamful sleep that insufficiency of heart-QI declines, palpitates with fear forgetful, the empty hyperhidrosis of body; Body fluid deficiency thirsty, quenches one's thirst; Blood deficiency sallow, dizzy; Impotence due to deficiency of the kidney, frequent micturition, deficiency of vital energy diseases caused by exogenous pathogenic factor.Radix Ginseng is suitable for crowd physical weakness, insufficiency of vital energy and blood, breathe hard, anemia person, neurasthenia.
(9) Cortex Moutan: Cortex Moutan is the root bark of Paeonia suffruticosa, cold in nature, bitter in the mouth, cool, be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Be antipyretic, there is clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Containing gallic acid, 5 hydroxymethyl furfural, the Quercetin of flavones ingredient, kaempferide, isorhamnetin, catechin, peoniflorin, caffeic acetate, apigenin, salvianolic acid A methyl ester, salvianolic acid N, rosmarinic acid, salvianolic acid A, alkannic acid B methyl ester, salvianolic acid B, galloylpaeoniflorin, succinic acid, volatile oil in Cortex Moutan, wherein contain 20 compounds in volatile oil, peonol content is maximum.Cortex Moutan has anticancer, antianaphylaxis asthma, protects the liver, atherosclerosis, antiinflammatory, the damage of anti-myocardial reperfusion, improve many-sided pharmacological action such as cognitive disorder, neuroprotective.
Compared with prior art the present invention has following beneficial effect.
1, the present invention with Folium Hippophae extract for monarch drug, take Radix Rhodiolae extract as ministerial drug, ensure that resisting fatigue, anti-hypoxia curative effect, with other 8 kinds of Chinese medicines for adjuvant, have adjusted tired the calming the nerves of dispelling of nerve, taste, liver and gall, kidney, brain-strengthening oxygenating, tonify deficiency righting, nourish the comprehensive function of primordial QI reinforcing, the function center showing prescription is based on righting primordial QI reinforcing, regulate metabolic balance, in righting, reach effect that resisting fatigue is got rid of evils.
2, the current application for Folium Hippophae is mainly based on tea making and beverage, and being used as medicine, is main mainly with Fructus Hippophae, adopts the Folium Hippophae person of being used as medicine few; Prescription of the present invention has taken into full account the property of medicine of Folium Hippophae composition, and reasonable compatibility is carefully solved, and combines multiple tonification Chinese herbal medicine, has been made into a kind of brand-new Chinese medicinal formulae; Simultaneously for the utilization of Folium Hippophae indicates a new approach.
3, the present invention all adopts the Chinese crude drug of integration of edible and medicinal herbs, and adopt modern extracting method, discard the dross and select the essential, achieve " Chinese medicine westernization ", reform prescription, with the extract side of entering, both decrease patent medicine volume, substantially increase active constituent content again, and improve the snap action of dose-effect and timeliness.
4, this formula is universe side's group medicine under instructing at Chinese medical theory " monarch ", and carry out pharmacology, toxicological test, and crowd takes and experimental basis completes, and test data is complete, and real result is credible, and effect has cogency.
5, this prescription both used guidance of traditional Chinese medicine theory, absorbed again the component analysis achievement of Modern Pharmaceutical Chemistry, embodied the generation novel composing prescription of the combination of Chinese and Western medicine---health care new product.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 540 parts, Radix Rhodiolae 200 parts, Radix Polygoni Multiflori Preparata 150 parts, Fructus Corni 100 parts, the Radix Astragali 80 parts, the Cortex Eucommiae 55 parts, Herba Epimedii 56 parts, Cortex Moutan 50 parts, Radix Ginseng 36 parts, calcium gluconate 28 parts.
Be prepared as follows:
By 9 of described mass distribution ratio kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:20 soaks 1h, then under temperature 60 C, extracts 2h continuously; By extracting solution after filtration, concentrated, drying obtains herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate powder by quality proportioning, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Embodiment 2
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 550 parts, Radix Rhodiolae 190 parts, Radix Polygoni Multiflori Preparata 140 parts, Fructus Corni 90 parts, the Radix Astragali 75 parts, the Cortex Eucommiae 60 parts, Herba Epimedii 60 parts, Cortex Moutan 60 parts, Radix Ginseng 40 parts, calcium gluconate 30 parts.
Be prepared as follows:
By 9 of described mass distribution ratio kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:15 soaks 1.2h, then under temperature 60 C, extracts 3h continuously; By extracting solution after filtration, cryoconcentration, lyophilization obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Embodiment 3
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 520 parts, Radix Rhodiolae 185 parts, Radix Polygoni Multiflori Preparata 100 parts, Fructus Corni 80 parts, the Radix Astragali 70 parts, the Cortex Eucommiae 50 parts, Herba Epimedii 50 parts, Cortex Moutan 45 parts, Radix Ginseng 33 parts, calcium gluconate 25 parts.
Be prepared as follows:
By 9 of described mass distribution ratio kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:25 soaks 1.5h, then ultrasound wave, mechanical agitation 120 revs/min, the air compressor machine airflow stirring of 3kw power is loaded, under temperature 60 C, extract 4h continuously; Extracting solution is filtered through duplex, vacuum concentration to quality than solid content: solvent=1:3, then through frozen drying powdered, obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, cold drying, sterilizing, capsule fill.
Embodiment 4
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 500 parts, Radix Rhodiolae 180 parts, Radix Polygoni Multiflori Preparata 120 parts, Fructus Corni 90 parts, the Radix Astragali 65 parts, the Cortex Eucommiae 40 parts, Herba Epimedii 55 parts, Cortex Moutan 40 parts, Radix Ginseng 30 parts, calcium gluconate 20 parts.
Be prepared as follows:
By 9 of described mass distribution ratio kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:22 soaks 1h, then ultrasound wave, mechanical agitation 120 revs/min, the air compressor machine airflow stirring of 3kw power is loaded, under temperature 60 C, extract 2h continuously; Extracting solution is filtered through duplex, vacuum and low temperature is concentrated into quality than solid content: solvent=1:2, then through frozen drying powdered, obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, cold drying, sterilizing, capsule fill.
Embodiment 5
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following weight distribution ratio:
Folium Hippophae extract 520 parts, Radix Rhodiolae extract 200 parts, Radix Polygoni Multiflori Preparata extract 120 parts, Fructus Corni extract 90 parts, Radix Astragali extract 70 parts, Cortex Eucommiae extract 50 parts, Herba Epimedii extract 56 parts, Cortex Moutan extract 45 parts, Radix Ginseng extract 30 parts, calcium gluconate 25 parts.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, by pulverize after material adopt 80% edible ethanol material in mass ratio: solvent=1:15 soaks 1h, then at temperature 55 DEG C, extracts 4h continuously; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Embodiment 6
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following weight distribution ratio:
Folium Hippophae extract 535 parts, Radix Rhodiolae extract 190 parts, Radix Polygoni Multiflori Preparata extract 130 parts, Fructus Corni extract 80 parts, Radix Astragali extract 60 parts, Cortex Eucommiae extract 55 parts, Herba Epimedii extract 55 parts, Cortex Moutan extract 60 parts, Radix Ginseng extract 40 parts, calcium gluconate 20 parts.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, by pulverize after material adopt 80% edible ethanol material in mass ratio: solvent=1:25 soaks 1.5h, then under temperature 50 C, extracts 3h continuously; Extracting solution is filtered through duplex, vacuum concentration to quality than solid content: solvent=1:3, then through frozen drying powdered, obtains herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Embodiment 7
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following weight distribution ratio:
Folium Hippophae extract 500 parts, Radix Rhodiolae extract 180 parts, Radix Polygoni Multiflori Preparata extract 100 parts, Fructus Corni extract 85 parts, Radix Astragali extract 65 parts, Cortex Eucommiae extract 45 parts, Herba Epimedii extract 50 parts, Cortex Moutan extract 50 parts, Radix Ginseng extract 35 parts, calcium gluconate 30 parts.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, by pulverize after material adopt 80% edible ethanol material in mass ratio: solvent=1:22 soaks 1.2h, then under temperature 60 C, extracts 2.5h continuously; Filtered through duplex by extracting solution, vacuum and low temperature is concentrated into quality than solid content: solvent=1:2, then through frozen drying powdered, obtains herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Embodiment 8
A kind of sea-buckthorn leaf anti-fatigue capsule, comprises the raw material of following weight distribution ratio:
Folium Hippophae extract 550 parts, Radix Rhodiolae extract 195 parts, Radix Polygoni Multiflori Preparata extract 150 parts, Fructus Corni extract 100 parts, Radix Astragali extract 80 parts, Cortex Eucommiae extract 60 parts, Herba Epimedii extract 60 parts, Cortex Moutan extract 40 parts, Radix Ginseng extract 35 parts, calcium gluconate 25 parts.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, by pulverize after material adopt 80% edible ethanol material in mass ratio: solvent=1:20 soaks 1h, then at temperature 65 DEG C, extracts 2h continuously; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
Food clothes example
1, Mr. Liu: 46 years old, Language Teacher.
Over nearly 3 years, normal sense without because of fatigue, on more tired after class, slightly take a turn for the better after rest, often have a dream in the evening, drowsy, and it is tired out that daytime often feels energy, the aching and limp discomfort of extremity, be afraid of that stair climbing is easily breathed, be afraid of to walk, walk how aching and limp with regard to both legs, and sexual disorder goes down.Can not check reason in hospital, electrocardiogram, electroencephalogram, hepatic and renal function is all normal, and patient's appearance looks does not have what obviously extremely yet, and within several years, seek medical advice without door, heart is very painful.Also take some nutritional supplements, but be difficult to obvious onset.
Take Jin Kehai antifatigue capsule every day 3 ~ 4, first feel after first quarter moon that dream in evening is few, sleep takes a favorable turn, and extremities aching pain greatly alleviates.After 30 days, 2 class get off and almost do not feel there is feeling of fatigue, evening majority can sleep one complete, climb 6th floors stair and also do not feel that nervous lower limb is soft, and be obviously improved the effect of sexual function.So far he taken 3 months continuously without because of feeling of fatigue substantially disappear.
2, Mr. Wang: 67 years old, retired employees.
Long-term smoking, every day one wraps; Noon every day, dinner are drunk with snacks each 2 Two that drink, and eating meat is fat.Mild asthma disease, hypertension, hyperlipidemia, fatty liver, diabetes are suffered from, chronic gastritis through examination in hospital.Within nearly 2 years, feel weak, dizzy, drowsiness, lower limb is aching and limp, and rest can not alleviate, and does not do things also tired, is also difficult to alleviate after sleep, the urine 3 ~ 4 times of getting up every night.
Take Jin Kehai antifatigue capsule every day 3 ~ 4, and the smoke which 1/3 that is situated between to fall.First feel after first quarter moon that evening, urine reduced to 2 ~ 3 times, dizziness alleviates, drowsiness minimizing, and lower limb is aching and limp to be alleviated, and cough alleviates.After taking 30 days, evening, urine reduced to 2 times, and without dizziness, without drowsiness, basic lower limb is seldom aching and limp, and cough alleviates further, and spirit is improved greatly.
3, Mr. Hou: 71 years old, retired cadre.
Like vegetarian diet for a long time, appetite is little, physical weakness,, often there is constipation in easy catching a cold, 3 ~ 4 hours every days were write article on computers or played games, time has grown VAOU reduction, blurred vision, fear of cold, weakness of the lower extremities, stand up lower limb with regard to ache, especially shank, can not go on a journey, get up every night urine 4 ~ 5 times, sleep quality is very poor.Suffer from severe diabetes mellitus through examination in hospital, suffer from the degeneration of old yellow class, prostatitis, varicosis.
Take Jin Kehai antifatigue capsule every day 3 ~ 4, first feel that evening, total urination time reduced to 3 ~ 4 times after first quarter moon, sleep quality improves, and fear of cold alleviates, and blurred vision makes moderate progress.After taking 30 days, evening, urine reduced to 2 times, and majority can have a sweet sleep, and work on computers and within 3 ~ 4 hours, also can not help too tired, blurred vision is greatly improved, and physical energy also has increase greatly, and lower limb ache also alleviates, and slowly can walk 20 minutes roads, does not substantially feel tired.
4, CHENNU scholar: 34 years old, civil servant.
Long-term seat office, happiness is eaten omnivorous, does not like motion, and body constitution is fat, and operating pressure is large, also will work overtime time many.Often feel weak, coolness of extremities, happiness heat is afraid of cold, dry mouth and throat, god is tired to breathe hard, dizzy, poor sleeping quality, dysphoria with feverish sensation in the chest palms and soles, menoxenia, menostaxis, lusterless complexion, and sexual disorder, can't help doing urine, and the empty hyperhidrosis of body, waist lower limb feels like jelly.Suffer from mild hypertension through examination in hospital, hyperlipidemia, blood viscosity is high, cyclomastopathy, and leukocyte count is greater than 400,000, has inflammation.
Take Jin Kehai antifatigue capsule every day 3 ~ 4, first feel after first quarter moon that dry mouth and throat drinks water minimizing, extremity start warm, and hyperhidrosis reduces, and dizziness alleviates.After taking 30 days, the of that month eumenorrhea, sexual function also has clear improvement, and had strength on foot, sleep quality improves greatly, does not even go a toilet a whole night.
Experimental example
Of the present invention in order to evaluate, invention has been the mice test of pesticide effectiveness and toxicity test and crowd and eat clothes test.
1, mouse anti-reflecting fatigue test
Experiment with Kunming kind SPF level mice, male and female half and half.Anti-fatigue test method mice is divided at random basic, normal, high 3 dosage groups and 1 matched group, often organizes 20.3 dosage component not with the extract gavage of capsule of the present invention, dosage is respectively 2.0,4.0,6.0gkg
-1d
-1; Matched group is with 6.0mLkg
-1d
-1normal saline gavage, each group experiment raises 30d all continuously, and between culture period, mice can freely ingest and drink water.After 30d gavage 1h, carry out swimming with a load attached to the body experiment.Right side of mice buttocks bundle is added the lead fuse wire be equivalent to from body quality 5%, then puts into 30 ± 1 DEG C, the tank went swimming of the depth of water 400 mm, do not have below upstream face 8s no longer to float with mouse head, be judged to be fatigue, record each group of tired time.
2, mice serum carbamide measures
Get mice 40, be divided into 4 groups, after last administration 30 min, at water went swimming 90 min of 30 DEG C, the 0.5mL of angular vein blood sampling immediately after 60 min that have a rest.3000 rmin after leaving standstill 3 h in 4 DEG C
-1centrifugal 15min, gets serum, measures serum urea value with automatic clinical chemistry analyzer.
3, blood lactase acid measures
After mice last administration 30 min, not born a heavy burden by mice, to be placed in water temperature be 30 DEG C, the depth of water be 35 cm swimming trunk in swimming 30 min; Have a rest after 20 min, angular vein is taken a blood sample.The centrifugal 15 min separation of serum of 2500rmin, adopt spectrophotometer method to measure Serum lactic acid content.
The result of the test of above-mentioned test 1,2,3 is listed in table 1.
Note: compare with negative control group, P<0.05 ± 1.1
Table 1 data is seen, the present invention compares with matched group, middle and high dosage group swimming time obviously extends, significant difference (P<0.01), and low dose group and matched group difference are not significantly (P>0.01).On the impact of serum urea nitrogen, Serum lactic acid content, middle and high dosage group compares with matched group, is all starkly lower than matched group (P<0.01).Tired topmost performance is that exercise tolerance declines.Experimental result shows, sea-buckthorn leaf anti-fatigue capsule of the present invention has the significant prolongation mice burden swimming time.Blood urea nitrogen is decomposed to form by body internal protein, and body internal protein oxidation energy supply degree is higher, and blood urea nitrogen content is higher, and body is poorer to motion fitness, and easier to be tired, this experimental result blood urea nitrogen content is low to be shown, mouse anti-reflecting fatigue ability strengthens.Reduce serum urea nitrogen and Serum lactic acid content, reflection sea-buckthorn leaf anti-fatigue capsule of the present invention has obvious antifatigue effect indirectly.
4, crowd eats clothes test
Blindly select 18 people, male 12 people, female 6 people, take product of the present invention 4 (quite pure extract mixtures 2g) for each person every day, 30 days time, inquire into the effect of sea-buckthorn leaf anti-fatigue capsule enhancing body endurance of the present invention and resisting fatigue.Questionnaire survey is adopted to join anthropophagy person's endurance and anti-fatigue ability raising situation after taking 1 month continuously, result shows: that takes sea-buckthorn leaf anti-fatigue capsule successful of the present invention accounts for 67.3%, what make moderate progress accounts for 25.6%, effective percentage is 92.9%, invalid accounts for 7.1%, compare with matched group and can significantly improve food and take personnel's endurance and anti-fatigue ability, difference has statistical significance (P < 0.01); And show that sea-buckthorn leaf anti-fatigue capsule of the present invention has the effects such as refresh oneself, alleviate prostatitis, improve Sexual potency, regulate asthenopia, sleep is stable.
5, mice polarity toxicity test
Select Kunming kind 19g ~ 21g healthy mice 40, male and female half and half, adopt group feeding, all by 0.4mg.kg
-1.d
-1extract gavage, observes 7d, has no any poisoning manifestations and death.Show that the present invention is to Mouse oral LD
50higher than 0.4mg.kg
-1.d
-1 ,belong to nontoxic level.By human body standard 70kg, LD
50>28g.d
-1, belong to nontoxic level health product.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from that, above-mentioned embodiment of the present invention all can only be thought explanation of the present invention and can not limit invention, claims indicate scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, any change in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (7)
1. a sea-buckthorn leaf anti-fatigue capsule, is characterized in that the raw material comprising following mass distribution ratio: Folium Hippophae 500-550 part, Radix Rhodiolae 180-200 part, Radix Polygoni Multiflori Preparata 100-150 part, Fructus Corni 80-100 part, Radix Astragali 60-80 part, Cortex Eucommiae 40-60 part, Herba Epimedii 50-60 part, Cortex Moutan 40-60 part, Radix Ginseng 30-40 part, calcium gluconate 20-30 part.
2. a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 1, to it is characterized in that in described raw material except calcium gluconate, other herbal raw material Folium Hippophae, Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Corni, the Radix Astragali, the Cortex Eucommiae, Herba Epimedii, Cortex Moutan, Radix Ginseng all adopt extract, and by extract weight, that is:
Folium Hippophae extract 500-550 part, Radix Rhodiolae extract 180-200 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Fructus Corni extract 80-100 part, Radix Astragali extract 60-80 part, Cortex Eucommiae extract 40-60 part, Herba Epimedii extract 50-60 part, Cortex Moutan extract 40-60 part, Radix Ginseng extract 30-40 part, calcium gluconate 20-30 part.
3. the preparation method of a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 1, it is characterized in that comprising the following steps: by 9 of described mass distribution ratio kinds of herbal raw materials through roguing, pulverizing, mixing, mixed material is adopted the edible ethanol material in mass ratio of 80%: solution=1:15-25 soaks 1h, then, under temperature 60 C, 2h is extracted continuously; By extracting solution after filtration, concentrated, cold drying obtains herbal raw material extract; Described herbal raw material extract is mixed homogeneously with described calcium gluconate, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
4. the preparation method of a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 2, it is characterized in that comprising the following steps: successively by described 9 kinds of herbal raw materials through roguing, pulverizing, material after pulverizing is adopted the edible ethanol material in mass ratio of 80%: solvent=1:15-25 soaks 1-1.5h, then, at temperature 50-65 DEG C, 2-4h is extracted continuously; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed mass distribution ratio mix homogeneously, obtains sea-buckthorn leaf anti-fatigue capsule product through granulation, drying, sterilizing, capsule fill.
5. the preparation method of a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 3 or 4, is characterized in that: the condition of described continuous extraction is the ultrasound wave, mechanical agitation 120 revs/min, the air compressor machine airflow stirring that load 3kw power.
6. the preparation method of a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 3 or 4, is characterized in that: described extracting solution adopts duplex to filter.
7. the preparation method of a kind of sea-buckthorn leaf anti-fatigue capsule according to claim 3 or 4, it is characterized in that: the extracting solution after described filtration, quality is concentrated into than solid content: solvent=1:2-3 through falling film evaporator, then through frozen drying powdered, herbal raw material extract powder is obtained.
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