CN101411489A - Compound Tibet sheep placenta capsule for delaying menopause and nursing face - Google Patents

Abstract

The invention belongs to the technical field of health care food, in particular to a hard capsule prepared from sheep placenta, nucleic acid, soy isoflavones, proanthocyanidins, saffron extract, angelica extract, Y-linolenic acid, vitamin E, vitamin C and other raw materials. The process for producing the capsule comprises the following steps: preparing and mixing the raw materials; stirring the raw materials; filling the raw materials in a capsule; sealing the capsule; and inspecting and packaging the capsule to produce a formal product. The product contains the sheep placenta, the nucleic acid, the soy isoflavones, the proanthocyanidins, the saffron extract, the angelica extract, the Y-linolenic acid, the vitamin E, the vitamin C and other raw materials, and has the advantages of staying and delaying climacteric period, delaying senility, beautifying and nourishing face and other efficacies.

Description

Compound Tibet sheep placenta capsule for delaying menopause and nursing face

One, technical field: the invention belongs to field of health care food, especially with raw materials such as Tibet sheep placenta, nucleic acid, isoflavones, OPC, angelica extract, safflower extract, y-leukotrienes, vitamin E, vitamin C, the health food of taking advanced technologies to make.

Two, background technology: this is invented with Tibet sheep placenta, nucleic acid, isoflavones, OPC, angelica extract, safflower extract, a kind of novel healthy food that y-leukotrienes, raw materials such as vitamin E, vitamin C process.This product is the hard capsule preparation that natural material is made, and effect is good, does not have any peculiar smell, taking convenience.Have and delay, postpone climacteric, skin maintenance effect.

Three, summary of the invention: perpetual youth, young beautiful charmed by the people since ancient times.Along with development in science and technology, will bring hope to the mankind.Human from now on just more and more younger beautiful.Especially to having crossed the women of puberty and child-bearing period, along with the loss in years, because ovarian function is old and feeble gradually, the organism endocrine balance changes, the minimizing of estrogen secretion, and it is dry, coarse that skin slowly becomes, follow the string, symptoms such as wrinkle, color spot occur, lose beautiful elegance.Therefore, how postponing the age in menstrual period, is the major issue that the female health preserving health care can not be ignored.Ahead of time in body, delay ovary aging and atrophy, can make women's health beauty, perpetual youth.

Four, composition of raw materials: Tibet sheep placenta 4-8 kilogram, nucleic acid 1-3 kilogram, isoflavones 0.6-0.9 kilogram, OPC 2-4 kilogram, angelica extract 6-8 kilogram, safflower extract 1-3 kilogram, gamma-Linolenic acid 1-1.5 kilogram, vitamin E 0.5-1 kilogram, Catergen-5 kilogram

Five, technical scheme

(1), Tibet sheep placenta (sheep ' s), (sheep placenta extracts).Be 3-5 months sheep embryo of tibetan sheep pregnancy, utilize biotechnology to extract biological activity.China's tradition traditional Chinese medicine is to animal placenta application history for a long time.According to Compendium of Materia Medica record, sheep placenta disposition temperature, sweet-salty.Effect with kidney tonifying, replenishing essence, benefiting qi and nourishing blood.The clinical men and women's of being used for consumptive disease, neurasthenia, qi-blood deficiency, spiritlessness and weakness, prolonged illness loss, spontaneous sweating, sexual disorder and endocrinopathy are caused a disease all effective in cure.The traditional Chinese medical science is thought tonifying Qi, nourish blood, replenishing vital essence function.Be used for impotence, seminal emission, women's insufficiency of vital energy and blood and infertile, few breast etc.Modern medicine study, the sheep placenta element is a kind of polypeptide protein material or perhaps the living cells thing that extracts from conceived sheep placenta dish, but this material activating human body skin and tracheae function, effectively promote body metabolism, strengthen immunity of organisms, promote human tissue cell's division, strengthen cytoactive, strengthen the Skin Cell power of regeneration, removing beverage, wrinkle-chasing, enhancing skin elasticity and gloss, delay youth, skin whitening, anti-ageing, relieving mental strain and helping sleep, improve memory, eliminate fatigue etc.

Chemical analysis: 1, steroid hormone: the steroid of being pregnant is bright, androsterone, estradiol, estriol, oestrone.2, placental hormone: promoting sexual gland hormone A, promoting sexual gland hormone B, lactogen, thyrotropic hormone, human chorionic gonadtropin, corticotropin etc.3, enzyme: kininase oxytocinase, lysozyme, globulin enzyme, hyaluronidase etc. are arranged.Contain DNA and nucleic acid, polypeptide protein, ten several amino acids, glutinous polysaccharide, lecithin, B family vitamin etc.Can produce various adjusting peptides, growth factor, cell factor, nucleic acid etc. rapidly according to external report sheep placenta element, and the active factors with superpower dna replication dna ability.

Pharmacological action: 1, anti-oxidant: the sheep placenta element was to 20 months healthy geriatric rat 150mg/kg every day body weight, 300mg/kg, 600mg/kg per os award the sheep placenta cellulose solution, after 80 days, measure respectively and respectively organize superoxide dismutase (SOD), MDA (MDA), monoamine oxidase (MAO) in rat red blood cell and the tissue.The sheep placenta element SOD content in the old rats red blood cell that can obviously raise reduces MAD content in serum and the hepatic tissue, and reduces brain tissue MAO vigor, so the sheep placenta element has antioxidation to old rats as a result.

It is reported that the foreign study experiment shows that (1) fruit bat average life span increases by 17.7%, human body is taken 15 days experimenter's lipid peroxides and is descended, and superoxide dismutase (SOD) value rises, and illustrating has positive effect to human body MDA (MDA), SOD.(2) rat blood serum and liver MDA descend 15%, and lipid oxide is had inhibitory action.(3) rat blood serum SOD raises 9.63%, and the manganese antioxidase raises 33.13%.

2, anti-ageing: the sheep placenta element has the irritation cell power of regeneration, delays senility.It is reported, sheep placenta is plain and umbilical cord contains embryonic stem cell and adult stem cell, these active components have face nourishing antidebilitation and act on always.

3, strengthen immunity; Studies show that, the sheep placenta element compares mouse nospecific immunity and specific immune function index analysis, the phagocytic function of thymus gland, index and spleen index and the mononuclear macrophage of the plain high dose group of sheep placenta, low dose group all obviously improves, the conversion reaction of SPL strengthens, serum hemolysin generation value also increases, so think that the sheep placenta element has the effect that improves the mouse body's immunity.

4, regulate endocrine: the sheep placenta element has obvious effects to regulating the hormone secretion function, can improve human body hormone secretion level, the aging of delaying female ovary, changes the ovary function, prevents climacteric obstacle, physiological change.

5, beautifying face and moistering lotion: studies show that, contain a series of micromolecule polypeptides such as peculiar superpower biologically active SF and BF in the sheep placenta element, its relative molecular weight is 3800-5000, it can activate Skin Cell regeneration, make it to breed degree of progress speed, activation skin surface tissue, removing also stops harmful oxide to be accumulated and melanocyte formation melanosome, color spot can't be formed, keep skin-whitening, promote elastin laminin cell proliferation, make the skin reticular fiber structure become closely flexible, keep moisture of skin to be difficult for running off and replenish skin-nourishing comprehensively, the balance skin metabolism is eliminated pachylosis, dry and cracked phenomenon makes skin become tender and lovely.Therefore the sheep placenta element has just enjoyed the women to welcome since coming out.

6, smooth away wrinkles: the sheep placenta element can promote elastin laminin cell proliferation, makes the skin reticular fiber structure become closely flexible, makes moisture be difficult for running off, and replenishes skin-nourishing comprehensively.According to another report, the loose wrinkling reason of the skin influence that is free radical.The sheep placenta element has the effect of oxidation and removing free radicals, can dispel facial wrinkles.

7, promote hematopoiesis, improve anaemia: research thinks, sheep placenta is plain can hematopoietic stimulation tissue, and promotion hematopoiesis has tangible anti-anaemia effect, and the effect of rising red blood cell significantly promotes the marrow hemopoiesis function, improves the asthenia universalis symptom.

8, smooth away wrinkles: sheep placenta have nourish blood, invigorate blood circulation, regulating menoxenias such as cool blood and blood, can make blood engorgement skin, be that skin obtains enough nutrition, can effectively dispel wrinkle and delay wrinkle and produce too early.

9, gonadotropic Effect: the sheep placenta element can promote the growth of women's secondary sex characters, promotes that endometrial hyperplasia is beneficial to embryo nidation and growth.According to another report, sheep placenta is plain gives lactation young rabbit injection, has the effect that promotes its growth, can significantly promote the growth of thymus gland, spleen, uterus, vagina, mammary gland; Thyroid gland, testis also there is the growth of promotion effect.

(2) nucleic acid (DNA, RNA) nucleic acid is extensively to be present in all animal and plant cells microorganisms, virus, intraphagic a kind of natural " gene food ".Indispensable nutrient.The phosphorus compound of this natural complexity of nucleic acid is physical basis of heredity, and the protein that can control cell is synthetic, control people's birth and old age, sickness and death.

Nucleic acid is divided into two big classes, and the one, DNA (RNA), the 2nd, ribonucleic acid (DNA) is present in each cell of human body.DNA exists in the nucleus, and RNA is more to be appeared in the cytoplasm liquid.

Scientific research confirms that nucleic acid has anti-ageing, improves immunity, and is anti-oxidant, anti-angiocardiopathy, and diabetes strengthen brain function, and PFT is anticancer, physiological functions such as beauty treatment.

Physiological function: 1, improve immunity: nucleic acid can strengthen the resistance of disease.Can improve leucocyte, the quantity of killer cell and neutrophil cell.Experiment shows that nucleic acid has the nospecific immunity of promotion and the specific immunity aspect all plays an important role.It is reported that nucleic acid can improve body's immunity.Experiment confirm is irritated hello an amount of nucleic acid to mouse, can improve the peritoneal macrophage phagocytic activity greatly, obviously strengthens specific antibody and central immune organ thymus index, and the spleen lymphocyte proliferation ability increases.Nucleic acid also is significantly improved to human body and regulates immunity function.

2, anti-oxidant, anti-ageing: nucleic acid can pass through vegetative cell, delays the aging of brain, skin, eyesight, muscle power and hair, is anti-ageing and one of the material of lengthening the life.Studies show that nucleic acid can promote sexual gland secretion telomere body gene enzyme, makes enzyme can synthesize the mononucleotide chain, the telomere body is replenished, thereby prolong frequency dividing cell, has also delayed the aging course of cell.Other has report, and nucleic acid can obviously reduce rat MDA, the active and raising GSH-R of increased SOD _xVigor.Nucleic acid also has utilization and improves the visceral injury that is caused by potein deficiency in addition.Symptoms such as body and cerebral function decline.Mouse is tested with nucleic acid product according to Japan, fed mouse with human body placenta DAN, experiment confirm can promote it to produce and grow, and promotes protein synthetic, and the mouse senile symptom of naturally-aged is obviously improved.The U.S. makes health products with nucleic acid and is used for the mankind and receives good anti-ageing effect.

3, protect liver: nucleic acid recovers to have important effect to liver function.Discover nucleic acid to the protection liver cell, promote that DNA is synthetic and liver cell is repaired and protein is synthetic that tangible effect all arranged.The effect that also has remarkable anti-hepatic fibrosis also has certain curative effect to the protein metabolism that improves chronic hepatitis and cirrhosis.

4, Eradicates wrinkle beauty treatment: nucleic acid can make wrinkle and skin spot disappear; Recent study finds that edible nucleic acid group food can delay senility, and can stop the generation of wrinkle of skin again.Because nucleic acid is a kind of life-information material, not only in protein is synthetic, plays an important role, and various metabolic waies and speed are also had certain influence.Skin Cell is one of the fastest cell of metabolism, will upgrade once in per about 15 days.Experiment showed, the nucleic acid of taking in some every day, can alleviate facial trickle wrinkle, nucleic acid has preserves moisture, and eliminates the superfluous acne that form of fat secretion, can make head hair cell proper splitting, improves alopecia and poliosis.

5, anti-angiocardiopathy: nucleic acid can be expanded peripheral vessel, increase the coronary blood liquid measure, improve myocardial metabolism, increase is to human body beneficial's HDL cholesterol, reduce harmful LDL cholesterol and other oxidation and deposition on vascular wall, thereby prevent artery sclerosis, prevent angina pectoris, miocardial infarction, cerebral thrombus.

6, improve diabetes: nucleic acid can activate damaged cells, and the more new cell of regeneration to be to guarantee the synthetic of insulin, symptoms such as effectively improving the insomnia of diabetic's polydipsia, eat hidrosis more, be weak.

7, improve memory: studies show that the increase of hemoglobin and affinity for oxygen has utilization to supply with cerebral tissue behind the edible nucleic acid, the increase of cell oxygen carrying content, thus eliminate fatigue not enough because of big cerebral oxygen supply and that shortage nutrition causes, improve ability of learning and memory.According to another report, nucleic acid can activate and increase brain cell, suppresses brain function decline, improves memory, prevents and improves senile dementia.

8, delay to postpone climacteric: after 46 years old, this is the aging phenomenon of irresistible physiology course to women's menopause greatly.Mainly show as ovarian function and fail gradually to complete obiteration, estrogen descends, and vegetative nerve functional disturbance causes spirit psychology, and the variation of neuroendocrine and metabolism causes the comprehensive symptom grouping of each tract sings and symptoms, is called its syndrome of climacteric.The physiological function of nucleic acid is: (1), can regulate endocrine disturbance, and---hypophysis---gonad function balance metabolism that makes hypothalamus, thereby the property alleviated disease is degenerated and every aging degradation symptoms such as sexual organ atrophy.Zoopery shows, the weight of ovary and testis is increased, and can remove mentally and psychological imbalance.(2), nucleic acid promotes sexual function and another interaction energy to impel a kind of telomere gene enzyme of glandular secretion, can form the DNA long-chain, constantly replenishes the needs of telomere body, the delay aging also helps the recovery of sexual function.(3), nucleic acid can enhance metabolism and energy is supplied with, and improves immunologic function, removes free radical, transfers the allomeric function of body, alleviates the change of various organs, therefore, nucleic acid has the involutional age of onset of postponement, alleviates climacteric metancholia.

9, control inferior health: studies show that, between health and morbid state, exist a kind of critical condition, be called " elicit illness state ", or be called " bringing out attitude ".When the body elicit illness state ran up to a certain degree, disease will take place.The interaction energy of nucleic acid makes human body be transformed to health by elicit illness state, thereby reaches healthy purpose.

10, radioresistance: nucleic acid has tangible protective action to 60 ℃ the mouse bone marrow cells chromosome damage that gamma-radiation caused, and the bone marrow cell micronucleus production rate is obviously reduced, and the DAN after CBC that ultraviolet ray the causes damage is repaired tangible enhancing.

11, improve function of intestinal canal: nucleic acid has important function to enteral nutrition, and it can promote that the function normal development is ripe and repair.Add nucleic acid and nucleotides in the milk powder and have the growth of the baby of promotion children stomach and intestine, improve stomach and intestine immunity and cellular immunity effect.Consumption by infants can strengthen the resistance to bacterium after adding the milk powder of nucleotides, reduces the generation of infantile diarrhea, lactic acid drink adds nucleic acid, can strengthen the propagation of Bifidobacterium (beneficial bacterium) in the enteron aisle, adjusts the enteron aisle flora, suppress harmful bacteria growing in the enteron aisle, keep intestinal health.

In addition, nucleic acid also have improve PFT, improve kopiopia, antiallergy, function such as anticancer.

(3), isoflavones (Soy isoflavone) isoflavones is a kind of natural bioactive ingredients that is present in the soybean, belongs to the isoflavones in the flavone compound.Quite similar at 26S Proteasome Structure and Function and human body estrogen, be called as phytoestrogen.Have the estrogenic effect of bidirectional modulation human body, help to keep the balance of women's hormone in vivo level.

Modern study thinks, that isoflavones has is anti-oxidant, control and postpone climacteric, improve immunity, effects such as control core barrel disease, cancer and osteoporosis.

Isoflavones is a kind of colourless crystalline lens, slightly has bitter taste, is subacidity, and phenolic hydroxyl group is many more in the molecule, and its acidity is strong more.Dissolve in alkaline solution and the pyridine, relatively poor to water-soluble, the isoflavones that exists with the glucosides form dissolves in hot water.

Physiological function: 1, anti-oxidant: the isoflavones antioxidation mainly shows as the direct scavenging action to free radical.It can suppress active oxygen radical, H ₂O ₂And the generation of MDA, its quenching effect to singlet oxygen also is very strong at present known antioxidant.There are some researches show, feed mouse, can significantly improve antioxidase, catalase, superoxide dismutase and the glutathione peroxidase reductase activity of organs such as mouse small intestine, skin with the feed that contains isoflavones.According to another report, the influence that has the human isoflavones that old rats is carried out T cell anti-ageing and anti-oxidant (hepatic tissue MDA MDA content and SOD vigor) is studied, the result confirms that isoflavones has inhibitory action to MDA, and the SOD vigor is had humidification.

2, estrogen-like action: isoflavones act as phytoestrogen, for women (women especially without offspring) healthy important effect is arranged.The women is before and after climacteric, because of various symptoms appear in estrogen secretion decline (is representative with the estriol).Though isoflavones is not a steroid hormone, it can combine with ERs and bring into play estrogenic benefit, it can be converted into materials such as the female phenol of horse in enteron aisle, the female phenol of horse is a kind of on-steroidal osajin estrogen with estrogen active, and it can two kinds of ERs ER-a of affinity and ER-b.The female phenol of horse is the final in vivo metabolite of Daidezin, and its chemical constitution is more stable, therefore has estrogen because of effect.FDA (Food and Drug Adminstration) (FDA) statement points out that isoflavones is the material of biologically active, is a kind of phytoestrogen, with the female estrogen structural similarity.

Help to keep the balance of female sex hormone level, have two kinds of important BAs, the two-way function of promptly female activity and antiestrogenic activity can complementing estrogen.

3, improve climacteric metancholia and premenstrual syndrome: studies show that isoflavones has the Menopause symptom of alleviation and health-care effect.As everyone knows, the women has arrived certain age, and the endocrine endogenous estrogen level of its body can obviously descend, along with and what come is a series of so-called climacteric metancholias.Once had the volunteer women of climacteric metancholia 14 48-56 years, and gave 40 milligrams of isoflavones every day, after 3 months, its symptom has all had improvement and disappearance in various degree.According to another report, the experiment isoflavones is to the effect of climacteric female sex hormone and symptom, not menopause women, climacteric, the women took isoflavones after 6 weeks, short ovarian follicle in the blood in climacteric is generated the effect of plain (FRH), interstitialcellstimulating hormone (ICSH) (LH), progesterone (P), stosterone (T), prolactin(PRL (PRH), estradiol (E2), to the degree of flushing, the spontaneous sweating of hectic fever in climacteric, vexed peaceful, insomnia and dreamful sleep, dizziness and tinnitus disease.The result shows, 35-45 year, 46-55 the year, the short ovarian follicle in the 56-65 year age group blood generates plainly, interstitialcellstimulating hormone (ICSH), hormone reduce, prolactin(PRL, estradiol raise; In 46-55 year, 56-65 year age group women symptom makes moderate progress.The mechanism of action be isoflavones can make climacteric and not in women's blood in climacteric ovarian follicle generate plainly, interstitialcellstimulating hormone (ICSH) reduces, prolactin(PRL, estradiol raises relevant.Find when the women carries out the isoflavones experiment before to menopause, take in 45 milligrams of isoflavones every day and can prolong menstrual cycle of female, prolong follicular phase especially.

4, protect against osteoporosis: osteoporosis is meant that the unit volume bone mass descends, but its composition does not change.Osteoporosis is subjected to the influence of factors such as age, hormone, heredity and nutrition, and menopause women osteoporosis most important reason is an estrogen deficiency and quicken bone-loss.Discover that estrogen level reduces, Gegenbaur's cell is stimulated weaken, bone is formed and bone absorption equilibrium imbalance, cause the menopause female bone to absorb and surpass bone formation and cause bone calcium to be lost, this is to cause the osteoporosis most important reason of falling ill.Experiment showed, that isoflavones can activate ERs, improve Gegenbaur's cell active and bone mineral content and bone density, promote bone metabolism and IGF to produce, thereby prevent and treat osteoporosis.

According to another report, the relation about Asia ethnic group application isoflavones and the loss of bone amount studies have shown that, takes the high dose isoflavones, can significantly reduce postmenopausal women's bone amount and run off.This is the research in 1 year by a definite date, has measured to be rich in isoflavone extract and 203 menopause to be less than the influence that China women in 10 years is run off to the bone amount.Research thinks that isoflavones has significant protective effect to bone loss.Therefore an amount of additional this phytoestrogen, to the adult female, especially to climacteric women, the prevention of osteoporosis tool has certain effect.

5, strengthen immunity: it is reported that isoflavones can improve immunologic function.The similar estradiol of isoflavones structure has female sample activity, therefore plays a role by influencing body's immunity.Someone once 8-10 week female mice by basic, normal, high isoflavones 10mg/kg * 30 day of giving respectively, 20mg/kg * 30 day, measure the thymus gland coefficient behind 60mg/kg * 30 day, the spleen coefficient, peritoneal macrophage phagocytic rate and phagocytic index, result show that 60mg/kg can strengthen the aging model immune function of mice.

6, anti-angiocardiopathy: cardiovascular disease is human dead important killer, is listed in one of the whole world three big diseases.Modern study is thought postclimacteric women, and its body inner estrogen level descends, and serum cholesterol level will obviously raise, and serum cholesterol and angiocardiopathy are closely related.Isoflavones has estrogen-like action, has certain effect to preventing and treating the angiocardiopathy tool.Studies show that isoflavones can make LDL cholesterol reduction in the blood plasma, and it is directly related with initial cholesterol concentration in the blood plasma to reduce effect, proves that isoflavones is more effective to the high people of blood fat.With isoflavones menopause women high cholesterol blood fat disease is treated, find that isoflavones can improve HDL-cholesterol and messenger RNA level.Research further finds, isoflavones has a protective effect to cardiovascular, and its mechanism of action is the oxidation of antioxidant CKIs, can reduce the body lipid peroxidating, thereby suppresses the oxidation of LDL.Once the women to 18-25 year carried out anti-oxidant experiment, and the result shows that picked-up 4 all isoflavones can significantly reduce lipid peroxidation value in the blood plasma, and significantly improves the aggregate level of blood plasma oxidation state (TAS).Therefore, isoflavones can reduce blood cholesterol, suppresses artery sclerosis, prevent and treat angiocardiopathy.FDA (Food and Drug Adminstration) (FDA) suggestion, an amount of isoflavones of picked-up every day then can make LDL-cholesterol levels reduction about 10% in the blood plasma, thereby reduce evidence of coronary heart diseases.

7, anti-curing cancers: epidemiological study finds that isoflavones is for breast cancer, and cancers such as prostate cancer, colon cancer, cancer of the stomach have significant preventive and therapeutic effect.And many-sided studies confirm that such as epidemiology, zoopery and human experimentation have been obtained.

The American Studies person finds that the female mammary gland cancer morbidity of Asian countries (China, Japan) is more much lower than west women, thinks that the absorption of soy food product has certain effect to preventing and treating breast cancer after 142857 women of Japan being reached 17 months research.In to Singapore and Japanese two control experiments carrying out, also find, clocklike take in the risk that soy food product can significantly reduce breast cancer before the menopause.It is reported, isoflavones can suppress breast cancer, experiment shows, isoflavones can weaken the disorders of lipid metabolism that animal causes after the spay in various degree, and daidzin may be the main component of above-mentioned effect, and isoflavones can significantly improve the weight in removal ovary animal vagina and uterus, improve removal ovary rat blood serum estradiol, reduce the serum lutropin; Its mechanism of action is expressed realization by improving ER (ERs) β, and estradiol is to express realization by improving ER; Isoflavones has dual regulation to people's isolated uterine intimal epithelium cell.Isoflavones and Genistein thereof can obviously suppress transplantable tumor growth in breast cancer cell growth in vitro and the nude mouse, and its mechanism of action and inducing apoptosis of tumour cell suppress tumor vessel and generate relevant.According to another report, american cancer research institute organizes the famous scientist in the whole America that the anticancer effect of isoflavones is discussed, and proves that isoflavones is effective natural anti-cancer material.Level according to zoopery and cell studies have shown that isoflavones can suppress the generation of breast cancer, prostate, colorectal cancer, cancer of the stomach, cutaneum carcinoma, liver cancer and leukaemia's proliferation function.

8, prevent and treat apoplexy: it is reported, discover that isoflavones can improve paralytic's arterial function for one of Hong Kong.The researcher finds, replenishes 80 milligrams of isoflavones every day, and 12 week back patients' artery blood flow makes moderate progress, and this is even more important for Ischemic Apoplexy Patients.This finds that the secondary prevention of cardiovascular patient is had important meaning.

(4), OPC (GPAPE SEED EXTRACT GSE) is to extract compounds from grape pip.The OPC molecule is by the catechin and the epicatechin be combined into of varying number, and it is generically and collectively referred to as the class polyphenolic substance.The simplest OPC is catechin and plain dimer, tripolymer, the tetramer and even ten pentamers that form of table youngster.In all kinds of OPCs, dimer distributes the widest, and research is maximum, a most important class OPC.The present OPC that identifies from grape pip comprises 3 monomers, 14 kinds of dimers (wherein 6 are soaked the gallate-based ester-formin), 11 kinds of tripolymers (wherein 3 kinds for soaking the gallate-based ester-formin) and a kind of tetramer.

OPC is a white powder, and astringent taste is arranged, can be water-soluble, and ethanol, methyl alcohol, acetone, ethyl acetate are insoluble to ether, chloroform, benzene etc., and the heating degradable generates anthocyanidin (Anthocyanidin) in acid solution.

Chemical composition: polyphenols: catechin, epicatechin and gallic acid.

OPC has multiple biologically active, is widely used in fields such as food, medicine, cosmetics.It is reported, OPC has significant removing free radical, delays senility, prevents and treats angiocardiopathy, hypertension, beauty treatment, the anti-adaptability to changes of enhancing human body, and diseases such as artery sclerosis, gastric ulcer, intestinal cancer, cataract, diabetes, heart disease, arthritis are had therapeutic action.

Physiological function: 1, anti-oxidant, delay senility: OPC since its molecular structure in polyelectron hydroxyl (phenolic group) part is arranged, be the good hydrogen and the donor of neutron, very strong oxidation resistance is arranged, be about 50 times, ascorbic 20 times of vitamin E in vivo.According to the laboratory report of the French academy of sciences, think that former florigen is that all find one of the strongest the most effective free radical scavenger up to now, especially activity in vivo is that other antioxidant is incomparable.Studies show that; the protective effect of lipid peroxidation compares in the brain tissue that OPC is induced TGA (12-0-14 acyl group Fo Er alcohol 13-acetic acid esters); equal in 100mg/kgGSE, vitamin C, vitamin E and beta carotene; the result is respectively 40%, 18%, 47% and 16% to the reduced rate that peritoneal macrophage takes place; use cytochromes reducing process reduced rate to be respectively 65%, 15%, 37% and 19%; explanation has protective effect to oxidative damage, and is better than other antioxidant.Under this external 120mg/L concentration, resistance ability to superoxide anion and hydroxyl radical free radical, GSE is 78% and 81%, and vitamin C is 12% and 19%, vitamin E is 50% and 78%, illustrate that GSE is a kind of very strong free radical scavenger, organize free-radical oxidation damage and old and feeble thereby alleviate.According to another report, OPC can provide the anti-oxidation protection effect by pair cell by blood-brain barrier, and the effect of prevention presenile disease is arranged, and makes harmful substance enter brain and brain is shielded stablizing blood-brain barrier.

2, the blood ester falling: it is reported, someone is separated into monomer and polymer with OPC and sneaks in the rat low fat feed and (account for 2%), to study its influence,, be control group with the high cholesterol beverage that does not add OPC with common low fat beverage effect normal group to each lipid of rat.The polymer group can significantly reduce the content of T-CHOL (TC), triglycerides (TG) and LDL-C (LDL-C) in the feeding high cholesterol beverage rat plasma and low-density lipoprotein (VLDL) as a result, and the content of raising HDL-C (HDL-C), in addition according to the result who measures cholesterol in the rat ight soil simultaneously, show that OPC poly physical efficiency stops the absorption of alimentary canal to cholesterol, a large amount of cholesterol therefore in the rat ight soil of high fat diet, occurs.Other has the laboratory report result to confirm, the mouse great and mighty or powerful that nursing contains the OPC beverage is after 6 weeks, and triglycerides and cholesterol in rat blood serum and the spleen all decrease, and serum cholesterol descends 18.1%, and the serum glyceride level reduces by 34.4%.

3, protection cardiovascular and cerebrovascular and bringing high blood pressure down: the elastomer in blood vessel oxidation hardening gradually is to cause hypertensive main cause.OPC can bring high blood pressure down by improving blood vessel elasticity.OPC can also improve VAR, reduces capillary permeability, and its anti-oxidant and antienzyme effect is by the in vivo studies model validation.Zoopery proof and clinical research are found, OPC can effectively reduce cholesterol and low-density lipoprotein white level in the blood, reduce cholesterol deposition and inhibition angiotonase activity on the vascular wall, the control thrombosis helps to prevent cardiovascular and cerebrovascular disease and hypertensive generation.Someone discovers that OPC can be treated the SH of rat, and demonstrates dose-effect relationship.Rabbit injection OPC 5mg/kg can alleviate blood pressure to plain I of anxiety and II should age due to systolic pressure increase, and the obviously low control group of test group blood pressure, its mechanism is the formation that OPC has reduced free radical, has improved the sensitiveness of insulin.

4, suppress tumour: the existing abroad a lot of research reports of the antineoplastic effect of OPC prove that OPC has cytotoxicity to some tumour cell.It is reported, there is human OPC OPC25mg/L to test external, result's proof has cytotoxicity to MCF-7 mankind mastopathy cell, A-427 human body lung carcinoma cell, CRL-1739 people's sdenocarcinoma of stomach and the chronic bone marrow leukemia cells of K562, growth resistance rate at 24,48,72 hours is respectively 7%, 30%, 43%, OPC can improve the growth and the survival ability of normal human subject mucous membrane cell and normal J7744A1 urothelial cell simultaneously, once gave 300mg/d to 92 phlebangioma patients, the pain after 28 days more than 75% disappears.

5, radioresistance: studies show that, can produce the endogenous free radical after the body raying, cause the lipid peroxidation equivalent damage, and OPC has the removing free radical, resist the effect of oxidative damage.Test report factually, with S ₁₈₀The sarcoma mouse carries out local irradiation with 60 ℃ gamma-rays respectively, oral OPC and local irradiation add the different modes of oral OPC and handle, behind the inoculation oncocyte the 12nd day, the knurl that detects animal subject was heavy, indexs such as white blood cell count(WBC), lymphocyte conversion ratio.Found that the knurl weight average of control group is significantly higher than other rank group.This may be because OPC can suppress the lipid peroxidation that radiation causes, thereby has the effect of Antiradiation injury.

6, crease-resistant, beauty treatment, beauty treatment: it is reported that OPC is enjoyed " skin vitamin " in American-European countries, the good reputation of " oral cosmetics ".Studies show that OPC is one of the most effective natural of present nature, has the ability of extremely strong removing skin free radical, thereby improves skin health, OPC can effectively reduce pigmentation simultaneously, prevents Dermatochalasia etc.According to another report, OPC has stronger ultraviolet-absorbing at the 280nm place, suppresses the pigmentation that the ultraviolet ray irradiation causes.OPC can suppress to participate in forming chloasma in addition, and melanic tyrosinase activity suppresses melanin and produces.Also can resist because of protein amino and the amino Maillard reaction that takes place of nucleic acid, thereby resist lipofuscin, senile plaque expelling can and be supported one's family and played synergy between C and the vitamin E.Therefore reach the effect of skin whitening.

OPC can be crease-resistant, and it can safeguard that collagen is synthetic, and the generation and the activity thereof of elastoser are improved skin elasticity and Dermatochalasia, thereby avoided and reduce the generation of wrinkle in the blocking-up skin.

7, antiallergy, anti-inflammatory: the OPC antioxidation activity makes it can suppress histamine, 5-hydroxytryptamine, prostaglandin, and the synthetic and release of leukotriene inflammatory factor, cell is had a liking in inhibition and mast cell discharges irritated particle, thereby effectively improves allergic symptom and allergic asthma symptom.In addition, it also can suppress the activity of histamine deshydroxy enzyme, and the effect of restriction hyaluronidase is remarkable to various arthritis and stomach, duodenal ulcer effect.

8, improve eyesight: discover, give the eye tired patient of 75 examples because of working for a long time with OPC before display screen, obey 300mg every day, after 2 months, its relative visual sense and nbjective symptom all have clear improvement.Experimenter's eyesight obviously improves as a result.

In addition, OPC also has effects such as protection liver, antiviral, anti-sudden change, antimycotic, antiulcer, antidepression.

(5) ZANGDANGGUI (Amgelica) is when the loose root that is classified as the perennial herb samphire.

Warm in nature, flavor is sweet puts down, has that blood circulation promoting and enriching, menstruation regulating are moisturized, the function of ease constipation.Functions such as brain tonic, protection liver, constipation.

Chemical composition: mainly contain volatile oil, linoleic acid, nicotinic acid, Cobastab ₁₂, polysaccharide, β-paddy stay compositions such as alcohol.

Pharmacological action: 1, strengthen immunity: Radix Angelicae Sinensis and Radix Angelicae Sinensis polysaccharide (AIP) are to non-specific immune function, cellular immune function, and humoral immune reaction and cell factor all have significant facilitation.The body that immunologic function is in holddown also has adjusting and restitution.

2, improve anaemia: Radix Angelicae Sinensis aqueous extract, Radix Angelicae Sinensis polysaccharide all can significantly promote the generation of hemoglobin, red blood cell, leucocyte and marrow nucleus.This act on that PBC reduces and marrow particularly evident when being suppressed.As giving the mouse abdomen injection stupid hydrazine of Radix Angelicae Sinensis polysaccharide or 60 ℃ of irradiations in advance, the recovery of mouse hematopoiesis function all there is significant facilitation.Chinese angelica oral liquid has tangible anti-anaemia effect, and in vitro culture also proves that Radix Angelicae Sinensis polysaccharide has the anemia mice of stimulation granulocyte, the effect of monosystem CFU-GM (CFU-GM) propagation.

3, protection liver: the Radix Angelicae Sinensis water decoction has protective effect to chmice acute CCL4 toxic hepatitis.And prevent that hepatic glycogen from reducing; With the Chinese Angelica Root forage feed mouse that contains 5% the liver oxygen demand is increased, it is stable that hepatic glycogen keeps.According to another report, the forulic acid that contains of Radix Angelicae Sinensis has protective effect to hepatic injury.Experiment shows that the sodium ferulate steel is the antagonism bromobenzene effectively, paracetamol, and number of chemical liver damages such as ethanol, and to hepatic ischemia, reperfusion injury and immunological liver injury have protective effect.

4, beauty treatment: Radix Angelicae Sinensis contains a large amount of volatile oil, vitamin, organic acid and trace element, waits multiple organic component, and experimental study shows that Radix Angelicae Sinensis can be expanded peripheral vascular, reduces vascular resistence, increases blood circulation amount etc.Can suppress melanin and form, to treat yellowish-brown class, freckle isochrome disposition skin disease has good effect.Someone adds Radix Angelicae Sinensis in cosmetic cream, the class's of the dispelling frost to, to ask for skin nutrition, prevents the yellowish-brown class of acne, effects such as freckle.Without any side effects through observing.Radix Angelicae Sinensis can promote natural on-off cycles of hair growth, and the hair conditioner elder generation hair cream with Radix Angelicae Sinensis is made can make hair soft shinny, is easy to combing.

5, prevent and treat gynaecological disease: from China Northern and Southern Dynasties, Radix Angelicae Sinensis is regarded as the treasure of invigorating blood circulation of enriching blood, its energy tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, damp face skin moisten, and the strong body of myogenic is promoted longevity, and is playing the part of extremely important role in the protection women's health.Li Shizhen (1518-1593 A.D.) thinks that Radix Angelicae Sinensis is the good medicine that the woman transfers blood.

6, delay to postpone climacteric: it is reported, when being extract energy later treatment climacteric metancholia.An experiment shows that angelica extract can delay and treat the effect of climacteric upsurge symptom.Have upsurge symptom and refusal to accept hormone to sharing the weal and woe together after 55 menopause, the women of replacement therapy takes the angelica extract that adds camomile, found that, 80% upsurge symptom is improved in the base, and it is more obvious to improve effect after 1 month.

7, the hemangiectasis angelica fluid can significantly be expanded the intestines mouse coronary artery that exsomatizes, and increases its CBF.Give the quiet notes Radix Angelicae Sinensis of anesthetized dog 2g/kg, coronary artery, brain and femoral artery affair flow all are significantly increased, each arteries resistance and MCO obviously reduce.Quiet parenteral solution 2g/kg can significantly reduce, and anesthetized dog is because of the experimental myocardial infarction scope of blocking-up during coronary artery, antagonism Experimental Rabbits myocardial ischemia.Give the quiet notes of the anesthetized dog 2g/kg of kidney type hypertension dog or normal blood pressure, angelica fluid or Chinese angelica volatile oil all can make blood pressure drops when satisfying each aqueous solution.

8, anti-arrhythmia: angelica extract can reduce myocardial excitability, prolongs the refractory period of extrasomatic rabbit heart, and to acetylcholine, the arrhythmia cordis that adrenaline causes has antagonism.Injection send the arrhythmia cordis of notes that obvious protective effect is arranged to the rat heart muscle ischemic again, and its effect is suitable with Verapamil 0.5/kg.In the isolated experiment of intestines mouse ventricular muscles bar, add 4.8 milligrams of 560 milligrams of angelol extracts or sodium ferulates and can resist cardiac arrhythmia due to divaside and the ouabain.

9, antibiotic disappearance: the Radix Angelicae Sinensis decoction need not have resistancing action with the examination dilution method to the tired bacillus of mouse, proteus, he shigella dysenteriae etc.Decoction increases inflammation capillary permeability due to the multiple proinflammatory agent, tissue edema and granulation tissue hyperplasia all have remarkable resistancing action, can reduce rat inflammation and organize the release of prostaglandin (PGEZ), can also reduce complement fixation test (CFT) GPC Supreme Being road haemolysis live body, alleviate the inflammatory reaction that some complement participates in.Sodium ferulate all has resistancing action to I-IV allergic reaction type, is of value to the adjustment body's immunity.

10, anti-oxidant: angelica extract send after to cerebral anoxia, ischemic again to be annotated the brain tissue MDA and increases the obvious suppression effect is arranged.Contained forulic acid can directly reduce, the content of H2O2, and combine with membrane phospholipid acyl monoethanolamine, the earthing is directly eliminated free radical, is suppressed the infringement of antagonism radical pair tissues such as oxidation reaction and radical reaction.

11, resist myocardial ischemia: angelica extract can increase the ability of mouse cardiac muscle picked-up; myocardial ischemia due to the foline after hang down stopping there is certain mitigation; the myocardial vascular capillary is increased; increase the myocardial blood supply, surveying when centrality has obvious protective effect to expeirmental myocardial ischemia side.

(6) Y-leukotrienes (GLA), Y-leukotrienes are the K6 series fatty acids that exists in the natural plant grease, are Y-linolenic isomers, are a kind of 6,7; 9,10; The polyphyly saturated fatty acid that has two keys between the former system of 12 and 13 carbon.The five colors or light yellow oil liquid.Water insoluble, be soluble in multiple organic solvent, iodine number is 273.5.

Modern study confirms that high fat of blood, diabetes, artery sclerosis, women's premenstrual syndrome, sclerotin sulphur pine disease, skin disease, gout, mistake presenility all lack relevant with Y-leukotrienes.

Physiological function: 1, regulate blood fat: it is stronger than other linoleic acid that Y-leukotrienes can reduce its effect of cholesterol in serum.Test confirms, Y-leukotrienes can obviously the raise level of HDL-C and the content of apolipoprotein-AI (apoA-I) in the serum reduce the level of LDL-C and apoB, and the control cardiovascular and cerebrovascular disease is had important effect.

2, synthesis of prostaglandins: Y-leukotrienes is that (precursor substance of PG-I and PG-II), prostaglandin PG-I and PG-II are the constituents of hormone to synthesis of prostaglandins, can cause the endocrine metabolism function seriously disorderly as shortage.

3, form the human body cell film: Y-leukotrienes is the essential part of human body cell film, can give cell membrane pliability, filling property and permselectivity, can lose intrinsic characteristic because of cell membrane after the shortage, and cause multiple disease.

4, skin moisten is crease-resistant: Y-leukotrienes can promote skin metabolism, improves the capillary blood circulation, the vitamin e of nutrition skin cell.Further research, Y-leukotrienes can also improve moisture of skin, keeps the moisture of skin balance, effectively prevents dry skin and aging, and women's blackspot, dry skin, wrinkle etc. are all had preventive and therapeutic effect.

5, anti-inflammatory: it is reported that the Jia Shuda scholar's research finds that Y-leukotrienes has very strong antiinflammatory action.Experiment shows that Y-leukotrienes can change dimerization Y-leukotrienes (DGLA) into through further metabolism, and then generates the eicosanoids of anti-inflammatory.DGLA and other metabolite also can influence heterogeneic expression, and these genes play an important role in immunity and Apoptosis.

6, improve women's premenstrual syndrome: discover that the women more than 60% through preceding so-called premenstrual syndrome (PMS) such as swollen breasts, general malaise can take place.Experiment shows, Y-leukotrienes can obviously improve the various symptoms of women through preceding comprehensive card, to 47 21.9 years old mean aves (19-21 years old 25,22-24 years old 17,25-35 years old 5) the women, give the 36mg leukotrienes every day, after 2 months, the health improvement rate of aching is 32.1%, and traffic law is improved as 29.4% bitterly, pain in the back improvement rate is 34.8%, mastosis improvement rate 28.6%.

7, anti-breast cancer: it is reported that the active ingredient Y-leukotrienes in month shellfish grass oil will become the sharp weapon of treatment breast cancer.Result of the test shows that the material in month shellfish grass oil can not only effectively suppress each important gene of breast cancer, can also strengthen the drug effect of anticarcinogen.Current research is the result show, it can suppress to cause the vigor of a kind of gene egg matter of breast cancer effectively the active component Y-leukotrienes in the evening primrose oil.Can reduce this protein level that can exempt to impel growth of cancer cells, have 30% patient with breast cancer all to cause at present by this gene protein.The test shows of Northwestern Univ USA, Y-leukotrienes can be regulated the growth of breast cancer cell, and the effect that is used in combination Y-leukotrienes and cancer therapy drug Trastuzumab is better, has significantly increased the apoptosis of cell, and reduces the growth of cancer cell.In addition, Y-leukotrienes also has the osteoporosis of control, diabetes, gout, the anti-ageing effect of waiting for a long time.

It is reported that the Y-leukotrienes has 60% effect to improving strong preceding syndrome.Its mechanism is because the Y-leukotrienes helps to produce prostaglandin.

8, Y-leukotrienes protection skin: the Y-leukotrienes also has in the important urn skin, hair and nail catches the effect of protecting; the Y-leukotrienes can form barrier one at skin surface; allow not lack of water of body, this barrier can also prevent constipation and the toxin of discharging storage in the body, have the effect of protection skin.

(7) safflower extract (Stigma croci) (safron, west safflower), the perennial perennial root herbaceous plant of Iridaceae safranine Pittosporum, croceous dried floral column cap.Sweet, the mildly bitter flavor of property.The traditional Chinese medical science thinks to have promoting blood circulation and removing blood stasis, blood-cleaning detoxifying, the resolving stagnation for tranquilization effect.Have analgesia, sweating stimulate the menstrual flow, dispel the wind cold, be good for the stomach, alleviate effects such as climacteric.Safflower is a rare traditional Chinese medicine simply, has unique effect aspect blood circulation promoting nourishes blood.According to Compendium of Material Medica record, safflower can " invigorate blood circulation, main motive melancholy, smelting palpitation with fear again." use safflower clinically and dredge channels and activating collaterals, the stagnation resolvation of stimulating the menstrual flow, the stasis of blood of loosing and open effects such as knot, swelling and pain relieving, removing pattogenic heat from the blood and toxic material from the body, troubled thoughts pent-up.By China and foreign countries' medical circle be widely used in anemia body void, irregular menstruation, postpartum blood stasis, have aches and pains all over, disease such as traumatic injury, neurasthenia, palpitation with fear are demented.Other has report, and safflower is very famous and precious simply Chinese medicine, has and nourishes blood, invigorate blood circulation, and cool blood, effects such as regulating menstruation by adjusting the flow of blood, be undivided with blood woman's all one's life, and energy and blood of human body is full, and the ability hair is deceived profit, skin is glossy.

Chemical composition: main component carotenoid is main pigment of safflower and active ingredient.Comprise the safflower aglycon, saffron glucoside and safflower mono-methyl, safflower dimethyl ester etc.It after the Picrocrocin hydrolysis volatile safranal.Volatile oil, diphenyl ethanol etc.

Pharmacological action: 1, anti-oxidant: the safflower extract has removing and inhibitory action to oxygen radical.

2, build up health: under long-term work and pressure, modern female physique relatively a little less than, very easily be subjected to virus evil to cause various diseases and gynaecological imflammation.And safflower can strengthen the immunologic function of cell, promotes the huge function of biting, and around the scavenger-cell " rubbish ", thereby plays self resistance, away from the effect of viral disease invasion.

3, transfer refreshing pneumostatic: work long hours and life stress, make the woman feel the mood unhappiness, discharge nowhere, particularly there is the anxiety sense in climacteric women regular meeting, feels to upset, and symptoms such as tired, unsmooth breath are arranged, so that temper becomes quick-fried dry.Safflower can be regulated endocrine, removes the color spot that causes because of endocrinopathy, and can in time promote the blood of human body circulation, the supply of blood oxygen, thus make women's qi and blood smooth and easy, keep good physical and mental statuse.

4, the skin makeup that nourishes blood: modern female gathers quickening because of work and life joint, causes symptoms such as anxious, sleep quality reduction easily, be reflected in the face skin anoxic, lose natural gloss, can occur when serious that the blood stasis of blood stagnates, pigment deposition, chloasma, color spot etc. occur.Safflower can be brought into play its anti-skin anoxic function of invigorating blood circulation to greatest extent, obviously stimulates circulation, and allows skin obtain sufficient blood oxygen, moisture and nutrition, makes skin dynamic, and fine and smooth moist, confidence gradually recovers one's health.

5, reducing blood lipid: the total glycosides of safflower can obviously suppress the rising of quail by serum TC, TG, LDL-C, VLDL-C and AI due to the high fat of blood diet, can alleviate artery due to the high fat of blood feed, the formation of AP, the safflower aglycon can reduce cholesterol, promotes lipid-metabolism.

6, suppress tumour: safflower 100-200mg/kg mouse gavaging is to S ₁₈₀, EC, MCA sarcoma all have the inhibition effect, its active ingredient is safflower aglycon (crocetin)

Also have in addition, promoting blood circulation and hemostasis, removing pattogenic heat from the blood and toxic material from the body, promote the arteria retina CBF, functions such as antifatigue, defaecation.

(8) vitamin E (Vit E) has another name called Vitamin E.Be Q, p, y and 6 Vitamin Es, Q, p, y and 6 triolefin Vitamin Es are called vitamin E with family system for 8 kinds.Wherein the biologically active of d one Vitamin E is the strongest.Vitamin E belongs to liposoluble vitamin, and is water insoluble, to the oxygen sensitivity, is easy to oxidation and destroys, and especially at sunlight, can quicken its oxidation under heat, the alkali condition, comparatively stable under acid oxygen free condition.

Physiological function: 1, anti-oxidant: vitamin E is a kind of very strong antioxidant, avoids the infringement of free radical at the protection cell membrane.Brain cell contains a large amount of unrighted acids, and vitamin E can prevent that unrighted acid is oxidized, thereby the eubolism of protection brain cell prevents brain oxidation decline with movable.But vitamin E is the neuroprotective system also, and skeletal muscle, retina are avoided oxidative damage, and the normal development of nerve system of human body and retina need sufficient vitamin E.With a large amount of free-radical generating, so vitamin is preventing mitochondria and neurally touches prominent film to avoid the free radical damage aspect be essential nervous system in producing the neurotransmitter process.

2, promote breast enlargement: vitamin E can impel development of ovary maturation, increases gonad cell, regulates estrogen secretion, thereby promotes lactiferous ducts to increase, and helps breast development to impel breast enlargement.Vitamin E can be prevented and treated and in utero put the ring excessive menstruation in addition, hypogalactia after delivery, antiabortive etc.

3, delaying decrepitude of skin: natural VE is described as " preserving the youth " vitamin.Because unique antioxidation can distend the blood vessels, and stimulates circulation, enliven skin cell metabolism, skin care increases skin elasticity and gloss, and offseting depigmentation calmness, chloasma, senile plaque expelling, striae of pregnancy and shallow table scar also has better action.

4, delaying wrinkle produces: wrinkle of skin is often because subcutaneous fat loses, and the fracture of elastomer and the degraded of collagen tissue produce, and vitamin E can stop the formation of lipid peroxide, and the protective tissue contact makes skin keep elasticity.Vitamin E is treated the effect of freckle in addition.

5, uvioresistant: studies show that; the antioxidant system of skin can reduce the damage of ultraviolet radiation to skin; and there is the vitamin E in the skin is to have protection skin; reducing ultraviolet radiation injury skin plays an important role; taking in vitamin E can be accumulated in the skin; and the vitamin E of skin can absorb some visible light ultraviolet rays, perhaps with ultraviolet ray " reflection " or " refraction ".Vitamin E has very strong anti-oxidation function on the other hand, reduces free-radical contents, to keep the immune system activity of cell.

According to another report, the ultraviolet ray irradiation can produce a large amount of high mars free radicals, and vitamin E can be repaired the epidermis injury that radiation produces as the powerful scavenger of free radical.

According to external, scientific research group of Dusseldorf ,Germany university, studies confirm that, vitamin E can make human body possess stronger anti-uv-ray, be vitamin E it can strengthen the function of other antiultraviolet material, and strengthen the ability that skin is better resisted radiation, this is to prove first that medically this may.Experiment showed, in uvioresistant and use, do not take vitamin E than the people who takes vitamin E low 29%.Therefore, vitamin E can strengthen the anti-ultraviolet ability of human body, prevents the generation of sunburn.In addition, vitamin E can also reduce the chloasma that sunburn causes.

6, prevent and treat chloasma and pigmented spots: pigmented spots medical science is called " senile pigmented spots ".It is a chemical substance of being lipofuscin pigment, also is the oxide of unrighted acid, i.e. lipofuscin.Vitamin E is the most important antioxidant of body, can prevent the peroxidating of unrighted acid in the body, and has the function of removing free radical, and to reduce the generation of lipofuscin, therefore, vitamin E can suppress the generation of pigmented spots.

According to external, megavitamin E continues 3～9 months, chloasma faciei and pigmented spots is reduced, even disappear, and efficiently reaches 70%～90%, and its mechanism mainly is to suppress lipid oxide to generate, and reverses skin senescence.According to another report, vitamin E has the effect of treatment freckle.

In addition, vitamin E can also improve the skin of head blood circulation, have anti-loss, the effect of white hair, skin pore can be secreted the health that to contain the vitamin E sebum, keep hair and beautiful.

(9) vitamin C (Vit c) has another name called ascorbic acid.It is the natural materials that extensively is present in the fruits and vegetables.Vitamin C is a kind of simple six carbon compounds, and occurring in nature has two kinds of existence forms, i.e. reduced form ascorbic acid and oxidized form hydroascorbic acid, and the both has physiologically active, all can be utilized by body.Vitamin C is a white crystalline powder, has tangible tart flavour, and is soluble in water, should not process under high temperature and alkali condition.

Physiological function: 1, participate in biosynthesis, vitamin C in vivo in the digestion process enzyme and the cofactors as substrate participate in multiple important biosynthetic process, comprise collagen, the synthetic and tyrosine metabolism of other neurotransmitter of carnitine and peptide hormone etc.Some enzyme require vitamin C could keep the activity of height.

2, reduction: vitamin C has the reduction of height, can make the ferric ion that is difficult to absorb be reduced into ferrous ion, promotes the absorption of enteron aisle to iron.Vitamin C can also increase the activity of some iron enzyme, thereby helps the utilization of iron.Therefore hypoferric anemia, except that mending ferrous preparation, it is just more obvious also must to take the vitamin C effect simultaneously.Vitamin C has anti-oxidation function, can also reduce superoxides, hydroxyl, hypochlorous acid and other activating oxide and other antioxidant for clearing free radical, blocking-up lipid peroxidation.

3, rich breast: vitamin C is a main component of keeping udder health, has important effect to keeping the connective tissue eubolism.Vitamin C impels cell to synthesize collagen to the young vigor of property features such as maintenance breast, and The Maintenance Of Skin Health and rich breast have important effect.

4, improve immunity, anti-flu: vitamin C can promote prostate and lymph liquid secretion, make body produce interferon and antitoxin, thereby play immunity and antivirus action, improve control ability, help to synthesize and to regulate lymphocytic prostaglandin body tissue.U.S. expert studies show that every day 1, gram left and right sides vitamin C can make flu descend 45%, and the course of disease shortens 60%.Vitamin C can be linked up respiratory apparatus and be stimulated circulation, and preventing respiratory infects, and strengthens the oxidation that body needs, and reduces flu and takes place.Vitamin C also has the skin health of keeping, the anti-ageing multiple function of waiting for a long time except above-mentioned functions.

5, skin whitening: vitamin C is to prevent that freckle from forming most important vitamin, and it can suppress melanic vigor, has the effect that keeps skin-whitening.Vitamin C and derivative thereof can play reduction to the melanin intermediate, thereby stop tyrosine and DOPA to change melanin on each branch of oxidation chain reaction.Vitamin C has the effect of prevention pigment deposition and bleaching skin.According to another research, vitamin C can suppress melanin and generate, to day sunburn, blackspot etc. have the effect that reduction is whitened, make the moist and elasticity of skin.

6, anti-ageing: vitamin C can be caught the outer free radical of cell membrane, and the protection body is avoided the infringement and the blood vessel endothelium system integrity of free radical.Vitamin C is an antioxidant, can prevent the subcutaneous fat oxidation, strengthens the vigor of skin surface and dermal cell, avoids skin early ageing.

In sum, this product has effects such as delaying, postpone climacteric, beautifying face and moistering lotion.

Manufacture craft: 1, allotment mixes: get raw materials such as Tibet sheep placenta, nucleic acid, isoflavones, OPC, angelica extract, safflower extract, Y-leukotrienes, vitamin C, vitamin E and mix, and stir.

2, capsule is filled: the raw material that will stir is sent into filling machine, and raw material is filled in the capsule.

3, capsule seals: the capsule with populated raw material, seal by standard.

4, test package: will seal the capsule of mouth, and be up to the standards, packing becomes formal product.It is that the raw material in the component design is mixed respectively by its physical characteristic that allotment mixes, and well-beaten operation, and this operation gets raw mix.It is the mixed material that preceding operation is made that capsule is filled, and is filled in the operation in the capsule.It is to fill the operation that the capsule of raw material seals that capsule seals, and this operation is that this operation gets the semi-finished product capsule, is up to the standards, and is packaged in the operation into formal product for the material composition in the capsule not easy consumption and capsule opening.

Six, quality standard:

1, physical and chemical index:

Tibet sheep placenta g/100g 18.2

Nucleic acid g/100g 4.6

Isoflavones g/100g 4.1

Former cyanine flower g/100g 9.1

Angelica extract g/100g 27.3

Safflower extract g/100g 4.6

Y-leukotrienes g/100g 6.8

Vitamin E g/100g 2.3

Vitamin C g/100g 22.8

2, instructions of taking: every day three times, each 0.5-0.7 kilogram, one after each meal.

3, be not suitable for the crowd: children and youth, patient with gout.

Seven, the specific embodiment: get raw materials such as 4 kilograms of Tibet sheep placentas, 1 kilogram of nucleic acid, 0.9 kilogram of isoflavones, 2 kilograms of OPCs, 6 kilograms of angelica extracts, 1 kilogram of safflower extract, 1.5 kilograms of Y-leukotrienes, 0.5 kilogram of vitamin E, 5 kilograms of vitamin Cs.

Raw materials such as sheep placenta element, nucleic acid, isoflavones, OPC, angelica extract, safflower extract, Y-leukotrienes, vitamin E, vitamin C are mixed, and stir and send into filling machine, in raw material filling and capsule, material composition in capsule leaks and the capsule opening, capsule is sealed, be up to the standards, packing becomes formal product.

Claims (2)

1, the compound Tibet sheep placenta capsule for delaying menopause and nursing face manufacture craft is: raw material allotment mixing, stirring, capsule raw material are filled, capsule seals, is up to the standards, and packing becomes formal product.

2, process conditions are: raw materials such as 4 kilograms of Tibet sheep placentas, 1 kilogram of nucleic acid, 0.9 kilogram of isoflavones, 2 kilograms of OPCs, 6 kilograms of angelica extracts, 1 kilogram of safflower extract, 1.5 kilograms of Y-leukotrienes, 0.5 kilogram of vitamin E, 5 kilograms of vitamin Cs mix, stir, send into filling machine, raw material is filled in the capsule, and capsule seals, is up to the standards to pack becomes formal product.