CN112868662A - Low-temperature efficient compound disinfectant and preparation method thereof - Google Patents
Low-temperature efficient compound disinfectant and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a low-temperature high-efficiency compound disinfectant and a preparation method thereof, and the related low-temperature high-efficiency compound disinfectant has the characteristics of wide bactericidal spectrum, obvious disinfection effect on coronavirus, staphylococcus aureus, candida albicans, pseudomonas aeruginosa and other germs, no toxicity, environmental protection, long acting and the like; the cold chain can be kept in a liquid state at the temperature of more than 40 ℃ below zero, can not be solidified, can still be sprayed and disinfected without freezing, can still keep the disinfection effect, can be used for disinfecting the surfaces of food packages and objects, can thoroughly solve the propagation problem in the links of production, processing, storage, transportation, circulation, transaction and the like, and can change the cold chain into a 'safe chain'. The novel low-temperature compound disinfectant is characterized in that auxiliary sterilization components are added, the sterilization efficiency and the sterilization spectrum of the product are greatly improved, and the novel low-temperature compound disinfectant has the characteristics of relatively low preparation cost, no residue, no drug resistance to various microorganisms, no toxic or side effect, simple and convenient use method and capability of meeting the requirements of low-temperature disinfectants.
Description
Technical Field
The invention relates to a low-temperature efficient compound disinfectant, in particular to a preparation method for preparing a low-temperature efficient compound disinfectant by a chemical method.
Background
The novel coronavirus can cause infection (direct transmission) by sneezing, coughing and speaking droplets of a patient, and the exhaled gas is directly inhaled in a short distance, and also can cause infection (contact transmission) because the droplets are deposited on the surface of an article and contact mucous membranes such as oral cavity, nasal cavity, eyes and the like after contacting a polluted hand. Certain disinfection measures are adopted to block the process of transferring pathogens from an infection source to a susceptible host, so that the occurrence and the cut-off transmission of diseases are prevented, and the diseases are prevented in the bud.
Because the new coronavirus has long survival time under low temperature condition, the imported cold chain food and the external package thereof can become a carrier for the trans-border transmission of the new coronavirus. With the gradual enhancement of national import cold chain food safety management, a traceability management platform is opened at present, the full chain informatization traceability from customs production, wholesale retail sale retail and catering services is basically realized, and the import cold chain management is continuously enhanced.
At present, the low-temperature disinfectant becomes a necessary consumable for disinfection in a low-temperature environment during the normalization of a new crown epidemic situation, and various phenomena appearing in the current market show that the demand of the low-temperature disinfectant is urgent. The low-temperature imported cold chain food disinfection is a new problem, and the point of damage is to manufacture a disinfectant with a disinfection effect under the low-temperature condition. The conventional disinfectant can not achieve the disinfection effect under the low-temperature environment, even the disinfectant freezes after being sprayed, the problem that alcohol is flammable and explosive is further overcome, and the problem of toxicity of the disinfectant is solved. The developed disinfectant can be still sprayed for disinfection and still can keep the disinfection effect when being kept in a liquid state, not solidified and not frozen within the range of minus 40 ℃ to 0 ℃, and can thoroughly solve the propagation problems in the links of production, processing, storage, transportation, circulation, transaction and the like when being used for disinfecting the surfaces of food packages and objects.
The types of the bactericides are various, and the bactericidal effect of the bactericides is influenced by the bactericidal components and the addition amount of the bactericides. Resistance to pests, bacteria, molds, viruses, and the like also affects the bactericidal effect. In the new century, green chemistry has received attention of broad scholars and becomes one of the international scientific research fronts. Therefore, at home and abroad bactericide researchers are focusing on the research and development of ideal bactericides with safety, high efficiency, environmental protection and broad spectrum. Because the ideal bactericide has high research and development cost and great difficulty, researchers mainly research the compounding, synergistic effect, action mechanism and the like of the bactericide at present.
Disclosure of Invention
The invention aims at solving some problems of the current low-temperature disinfectant, develops a low-temperature efficient compound disinfectant in a targeted manner, and aims to provide a low-temperature efficient compound disinfectant which has the advantages of good low-temperature performance, good disinfection effect, no toxicity, environmental protection and low cost.
The quaternary ammonium salt and guanidine disinfectant is a novel environment-friendly disinfectant, has strong sterilization and bacteriostasis performance, broad spectrum, high efficiency, long validity period, no toxic or side effect, no corrosiveness and irritation, safe use, degradability under natural environment, environmental friendliness and no pollution, and is a main component for developing novel disinfectants in recent years.
The quaternary ammonium salt bactericide comprises two types of single-chain (such as benzalkonium chloride and benzalkonium bromide) and double-chain quaternary ammonium salt (such as didecyl dimethyl ammonium chloride and DDAC), one end of the quaternary ammonium salt bactericide is positively charged, and the other end of the quaternary ammonium salt bactericide is a cationic surface active disinfectant, wherein the sterilization mechanism is that the positively charged quaternary ammonium salt unit is adsorbed on the surface of a negatively charged bacterium, and the long-chain alkyl/aryl unit is combined with substances on a cell lipid layer as a lipophilic group to damage the cell wall and cell membrane structure of the bacterium, so that the cell permeability is changed, the substances in the cell are leaked out, the activity of related enzymes is inhibited, and proteins are denatured, so that the bacterium is killed.
Guanidine bactericide includes chlorhexidine acetate, chlorhexidine gluconate, polyhexamethylene monoguanidine, polyhexamethylene biguanide salt derivative, etc., for example, chlorhexidine acetate and chlorhexidine gluconate compound preparation are sold in market. The guanidine sterilization mechanism is similar to that of quaternary ammonium salt, and guanidine with a large number of positive charges can be quickly adsorbed to the surface of bacteria to replace Mg stably existing on the surface of the bacteria2+、Ca2+Mainly interacts with lipopolysaccharide, peptidoglycan components on cell walls and cell plasma membranes, so that the phospholipid environment of the cell membranes is changed, biological dysfunction of the cell membranes is caused, the structure of the cell plasma membranes is damaged, and the microorganism is killed. In addition, polyhexamethylene mono/biguanide (PHMG/PHMB) as a polymer can form a membrane on the surface of the microorganism to close its respiratory tract, thus asphyxiating the bacteria. It is known that single-component bactericidal spectrum is narrow, for example, the dosage of 100% of polyhexamethylene guanidine hydrochloride for the sterilization rate of escherichia coli, staphylococcus aureus and candida albicans is only 200ppm, but the single-component bactericidal spectrum is not suitable for killing cell spores. Such as quaternary ammonium salts, have the same bactericidal activity against pseudomonas aeruginosa, which is common in hospital surgical operating rooms, in addition to polyhexamethylene guanidine hydrochlorideThe bacteria have certain bactericidal capacity, wherein the dosage with the bactericidal rate of 99.999 percent is only 39ppm, but the effect of virus inactivation is weak. Research shows that when the active components are compounded in a certain proportion, the disinfectant has a synergistic effect, and the compounded disinfectant can broaden the bactericidal flora and enhance the bactericidal capacity, and in addition: the compounded disinfectant can effectively reduce the dosage of the disinfectant under the condition of ensuring the sterilization standard, and the purposes of high efficiency, low toxicity, economy and practicability are realized.
The low-temperature efficient compound disinfectant and the preparation method thereof are characterized in that the low-temperature efficient compound disinfectant and the preparation method thereof are prepared from the following components in percentage by weight:
the low-temperature efficient compound disinfectant is characterized in that the dosage of polyhexamethylene biguanide hydrochloride (PHMB) is 0.01-3.0%; the water-soluble quaternary ammonium salt is one or more of benzalkonium chloride/bromine amine, Didecyl Dimethyl Ammonium Chloride (DDAC), benzethonium chloride/bromine ammonium and organosilicon quaternary ammonium salt, and the dosage of the water-soluble quaternary ammonium salt is 0.05-0.4%.
The auxiliary bactericide is one or more of aliphatic polyoxyethylene ether (AEO), polyethylene glycol (PEG), polyoxyethylene octyl phenol ether-10 (OP-10) and nonylphenol polyoxyethylene ether (NP-10), and the dosage of the auxiliary bactericide is 0.01-3.0%.
The stabilizer is one or more of polyvinyl alcohol, chlorinated-2-hydroxy-3- (trimethylamino) propyl polyethylene oxide cellulose ether and polyvinylpyrrolidone, and the dosage of the stabilizer is 0.01-1.50%.
The low-temperature efficient compound disinfectant is characterized in that the antifreezing agent is one or a mixture of more than one of methanol, ethanol, isopropanol, n-propanol, ethylene glycol, glycerol, sorbitol, xylitol and n-butanol (for example, the ratio of methanol to ethanol to isopropanol is 2:4:1), and the dosage of the antifreezing agent is 20-50.0%.
The surfactant is one or more of cocamidopropyl betaine (CAB), Alcohol Ether Glycoside (AEG) and Alkyl Polyglycoside (APG), and the dosage of the surfactant is 0.1-2.0%.
The low-temperature efficient compound disinfectant is characterized in that the essence is one of rose, jasmine, lavender, sandalwood, mint, strawberry and the like in plant essence, and the dosage of the essence is 0.001-0.5%.
The low-temperature high-efficiency compound disinfectant is characterized in that the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), water-soluble quaternary ammonium salt, auxiliary bactericide, stabilizer, antifreeze, surfactant and essence in a certain proportion into a reaction kettle with mechanical stirring, and adding pure water to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 0.5-3 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
The invention has the following advantages:
the main effective sterilization components of the low-temperature high-efficiency compound disinfectant provided by the invention are nontoxic and environment-friendly macromolecular guanidine, double-chain quaternary ammonium salt and auxiliary components, a layer of macromolecular protective film can be formed on the surface of an object, and the effects of long-acting sterilization and bacteriostasis can be achieved.
The low-temperature high-efficiency compound disinfectant provided by the invention adopts compound components, and particularly, the added auxiliary bactericide can greatly improve the sterilizing effect of the bactericide on the basis of the original formula, and has the advantages of small using amount, good sterilizing effect and wide sterilizing spectrum.
The low-temperature high-efficiency compound disinfectant provided by the invention has the advantages of simple preparation process, low equipment requirement and relatively low cost.
The low-temperature high-efficiency compound disinfectant provided by the invention is green, environment-friendly, free of toxic and side effects and wide in application range.
The low-temperature high-efficiency disinfectant provided by the invention can kill coronavirus within 5min after the action, can kill pathogenic bacteria such as escherichia coli, staphylococcus aureus, candida albicans, influenza virus and the like within 1min, and has the killing rate of over 99.999 percent.
Detailed Description
The present invention will be described in further detail with reference to the following examples.
Example 1
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), Didecyl Dimethyl Ammonium Chloride (DDAC), an auxiliary bactericide (aliphatic polyoxyethylene ether AEO-9), a stabilizer (chlorinated-2-hydroxy-3- (trimethylamino) propyl polyethylene oxide cellulose ether), an antifreezing agent (methanol: ethanol: n-propanol: 1:2:1), a surfactant (alkyl polyglycoside (APG)), essence and pure water in a certain proportion into a reaction kettle with mechanical stirring to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 2
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.5％ |
| Benzethonium chloride (1227) | 0.15％ |
| Auxiliary bactericide (polyethylene glycol-800) | 0.4％ |
| Stabilizer (polyvinylpyrrolidone (PVP-K30)) | 0.1％ |
| Antifreeze (ethanol: propylene glycol: n-propanol ═ 1:2:1) | 35％ |
| Surfactant (alcohol ether glycoside AEG) | 0.5％ |
| Essence | 0.1％ |
| Pure water | Balance of |
The preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzethonium chloride (1227), an auxiliary bactericide (polyethylene glycol-800), a stabilizer (polyvinylpyrrolidone (PVP-K30)), an antifreezing agent (ethanol: propylene glycol: n-propanol: 1:2:1), a surfactant (alcohol ether glycoside (AEG)), essence and pure water in a reaction kettle with mechanical stirring in a certain proportion to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.2 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 3
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzalkonium chloride, an auxiliary bactericide (aliphatic polyoxyethylene ether AEO-9), a stabilizer (polyvinyl alcohol (PVA), an antifreezing agent (ethanol: ethylene glycol: isopropanol: 1:3:1), a surfactant (cocamidopropyl betaine (CAB-35)) into a reaction kettle with mechanical stirring in a certain ratio, respectively, adding essence, and adding pure water for supplementing the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.5 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 4
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), Didecyl Dimethyl Ammonium Chloride (DDAC), an auxiliary bactericide (polyoxyethylene octylphenol ether-10), a stabilizer (polyvinyl alcohol (PVA)), an antifreezing agent (ethanol: ethylene glycol: isopropanol ═ 2:2:1), a surfactant (cocamidopropyl betaine (CAB-35), essence and pure water in a certain proportion into a reaction kettle with mechanical stirring to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.5 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 5
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
| polyhexamethylene biguanide hydrochloride (PHMB) | 0.35％ |
| Benzethonium chloride (1227) | 0.15％ |
| Auxiliary bactericide (nonylphenol polyoxyethylene ether) | 0.6％ |
| Stabilizer (polyvinylpyrrolidone (PVP-K30)) | 0.2％ |
| Antifreezer (glycerin: propylene glycol: isopropanol ═ 1:2:1) | 20.0％ |
| Surfactant (alcohol ether glycoside AEG) | 0.5％ |
| Essence | 0.1％ |
| Pure water | Balance of |
The preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzethonium chloride (1227), an auxiliary bactericide (nonylphenol polyoxyethylene ether), a stabilizer (polyvinylpyrrolidone (PVP-K30)), an antifreezing agent (glycerol: propylene glycol: isopropanol: 1:2:1), a surfactant (alcohol ether glycoside AEG), essence and pure water in a reaction kettle in a mechanical stirring manner according to a certain proportion to make up the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.3 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 6
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzethonium chloride (1227), an auxiliary bactericide (polyethylene glycol-800), a stabilizer (polyvinylpyrrolidone (PVP-K30)), an antifreezing agent (glycerol: propylene glycol: isopropanol ═ 1:2:1), a surfactant (cocamidopropyl betaine (CAB-35), essence and pure water in a reaction kettle in a certain proportion to make up the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.2 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 7
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzethonium chloride (1227), an auxiliary bactericide (nonylphenol polyoxyethylene ether), a stabilizer (polyvinylpyrrolidone (PVP-K30)), an antifreezing agent (glycerol: propylene glycol: isopropanol: 1:2:1), a surfactant (cocamidopropyl betaine (CAB-35), essence and pure water in a certain proportion into a reaction kettle with mechanical stirring to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1.5 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 8
The low-temperature efficient compound disinfectant is prepared from the following components in percentage by weight:
the preparation method comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding polyhexamethylene biguanide hydrochloride (PHMB), benzethonium chloride (1227), an auxiliary bactericide (aliphatic polyoxyethylene ether AEO-9), a stabilizer (polyvinylpyrrolidone (PVP-K30)), an antifreezing agent (ethanol: propylene glycol: isopropanol: 2:1), a surfactant (alcohol ether glycoside AEG), essence and pure water in a certain proportion into a reaction kettle with mechanical stirring to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 1 h;
(4) and (3) filtering the uniformly stirred solution (filtering with a 5-micron filter membrane), and filling to obtain the low-temperature high-efficiency compound disinfectant.
Example 9
The following is an analysis and detection report provided by a third-party detection institution (engel detection technology service (shanghai) ltd.), the test item is a one-time complete skin irritation experiment of a disinfection product, and the sample is the low-temperature high-efficiency compound disinfectant of the embodiment 3.
Sample state: normal appearance and no obvious defect.
The following are analysis and detection reports provided by a third-party detection organization (invitrogen detection technology service (shanghai) ltd), the detection items are a neutralizer identification test (candida albicans) and a fungus quantitative killing test (candida albicans), and the sample is the low-temperature high-efficiency compound disinfectant of the embodiment 3.
First, equipment
1. Test strains: candida albicans was provided by Invitrogen detection technology service (Shanghai) Inc., 5-6 generation fresh slant cultures.
2. Test samples: the multifunctional high-efficiency compound disinfectant of example 3.
3. Neutralizing agent: 0.5% sodium thiosulfate in PBS.
4. And others: 3% organic interferents, standard hard water, etc.
Second, method
1. The detection basis is as follows: the neutralizer identification test and the fungus quantitative killing test were carried out according to the Disinfection technical Specification of the Ministry of health (2002) 2.1.1.5.5 and 2.1.1.7.
2. And (3) identification test of a neutralizer: the test sample is reacted with standard hard water 1:4 diluent and Candida albicans for 0.5 min. The test temperature was-19 to-35 ℃ and the test was repeated 3 times.
3. Quantitative fungus killing test: the action time of the test sample stock solution is 1.25min, 2.5min and 3.75min respectively. The test temperature was-19 to-35 ℃ and the test was repeated 3 times.
Three, result in
1. Neutralizer identification test
In 3 repeated experiments, the error rates of recovered colonies of three groups, namely 3 groups, 4 groups and 5 groups, are respectively 8.33 percent, 6.67 percent,
5.46 percent. The results are shown in Table 2.
In the table are the results of the identification test of the neutralizing agent
Note: the negative control group was grown aseptically.
2. Killing effect on test bacteria
After 3 times of repeated tests, the results show that the low-temperature high-efficiency compound disinfectant has the killing logarithm value of being greater than 4.00 in 1.25min, 2.5min and 3.75min of the action on the candida albicans, and the results are shown in table 3.
Shown in the table are the results of the quantitative fungus killing test
Fourth, conclusion
1. After repeated experiments for 3 times, the results show that the PBS solution of 0.5 percent of sodium thiosulfate can neutralize the sterilization components in the compound disinfectant, and the neutralizer and the neutralized products have no obvious influence on the growth of the test bacteria and the culture medium. The neutralizing agent is indicated to be suitable for the quantitative killing test of the test sample on the candida albicans.
2. Repeated experiments for 3 times show that the low-temperature high-efficiency disinfectant has killing logarithm value of more than 4.00 in 1.25min, 2.5min and 3.75min of Candida albicans in suspension.
In conclusion, the low-temperature efficient compound disinfectant can be applied to the environment with the temperature range of-40 ℃ to 0 ℃ and is used for disinfecting the surfaces of food packages and objects, the problem of disinfection in the links of production, processing, storage, transportation, circulation, transaction and the like can be thoroughly solved, the polymer polyhexamethylene guanidine hydrochloride and the double-chain quaternary ammonium salt are used as effective disinfecting components of the disinfectant, auxiliary disinfecting components are added, and a stabilizer, an antifreezing agent, a surfactant, plant essence and purified water are added, so that the novel green efficient low-temperature disinfectant is developed, has high killing activity and good disinfecting effect in the low-temperature environment, and can effectively prevent repeated infection. Meanwhile, the disinfectant has no corrosiveness (no corrosive substance, mild and no stimulation, and pH close to neutral), has strong stability and no pollution to the environment, is liquid at normal temperature, has high activity at low temperature, and can form a polymer protective film on the surface of an object after disinfection, so that the disinfectant can play a long-acting sterilization and disinfection effect, and can effectively prevent repeated infection.
The above specific examples are only a few embodiments of the present invention, and modifications and variations can be made to the formulation and preparation method of the present invention without departing from the scope of the present invention, and these modifications and variations should also be construed as within the scope of the present invention.
Claims (10)
1. The low-temperature efficient compound disinfectant is characterized by being prepared from the following components in percentage by weight:
2. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the amount of the polyhexamethylene biguanide hydrochloride is 0.01-3.0%; the water-soluble quaternary ammonium salt is one or more of benzalkonium chloride/bromine amine, didecyl dimethyl ammonium chloride, benzethonium chloride/bromine ammonium and organosilicon quaternary ammonium salt, and the dosage of the water-soluble quaternary ammonium salt is 0.05-0.40%.
3. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the auxiliary disinfectant is one or more of aliphatic polyoxyethylene ether, polyethylene glycol, polyoxyethylene octyl phenol ether-10 and nonylphenol polyoxyethylene ether, and the dosage of the auxiliary disinfectant is 0.01-3.0%.
4. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the stabilizer is one or more of polyvinyl alcohol, chlorinated-2-hydroxy-3-trimethyl amino, propyl polyethylene oxide cellulose ether and polyvinylpyrrolidone, and the amount of the stabilizer is 0.01-1.50%.
5. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the antifreezing agent is one or a mixture of methanol, ethanol, isopropanol, propylene glycol, n-propanol, ethylene glycol, glycerin, sorbitol, xylitol and n-butanol, and the dosage of the antifreezing agent is 20.0-50.0%.
6. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the surfactant is one or more of cocamidopropyl betaine, alcohol ether glycoside and alkyl polyglycoside, and the dosage of the surfactant is 0.1-2.0%.
7. The low-temperature efficient compound disinfectant as claimed in claim 1, wherein the essence is one of rose, jasmine, lavender, sandalwood, mint, strawberry and the like in plant essence, and the usage amount of the essence is 0.001-0.5%.
8. The preparation method of the low-temperature high-efficiency compound disinfectant is characterized by using the component composition of claim 1, and comprises the following steps:
(1) dissolving solid medicine or pasty medicine in the ingredient table in water in advance, and preparing into water solution with corresponding concentration for later use;
(2) adding a proportion of polyhexamethylene biguanide hydrochloride, water-soluble quaternary ammonium salt, auxiliary bactericide, stabilizer, antifreezing agent, surfactant and essence into a reaction kettle with mechanical stirring, and adding pure water to supplement the balance;
(3) mechanically stirring the mixed solution for a certain time, wherein the stirring time is 0.5-3 h;
(4) and filtering the uniformly stirred solution, and filling to obtain the low-temperature high-efficiency compound disinfectant.
9. The preparation method of the low-temperature high-efficiency compound disinfectant as claimed in claim 8, wherein the step (4) is performed by filtration with a 5 μm filter membrane.
10. The preparation method of the low-temperature high-efficiency compound disinfectant as claimed in claim 8, wherein the antifreezing agent is propylene glycol: ethanol: the n-propanol ratio was 1:2: 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113396906A (en) * | 2021-06-28 | 2021-09-17 | 白燕波 | Composite quaternary ammonium salt low-temperature disinfectant and preparation method thereof |
| CN113481067A (en) * | 2021-06-02 | 2021-10-08 | 兰州石化职业技术学院 | Laundry detergent with anti-bacterial function and preparation method thereof |
| CN114652741A (en) * | 2022-01-19 | 2022-06-24 | 昆明野水生物科技有限公司 | Composition and preparation for inhibiting HPV and application thereof |
| CN114868762A (en) * | 2022-04-23 | 2022-08-09 | 杭州西子卫生消毒药械有限公司 | Composite intermediate-effect disinfectant and preparation method thereof |
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| CN101812383A (en) * | 2010-05-20 | 2010-08-25 | 北京绿伞化学股份有限公司 | Disinfecting detergent and preparation method thereof |
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| CN101812383A (en) * | 2010-05-20 | 2010-08-25 | 北京绿伞化学股份有限公司 | Disinfecting detergent and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113481067A (en) * | 2021-06-02 | 2021-10-08 | 兰州石化职业技术学院 | Laundry detergent with anti-bacterial function and preparation method thereof |
| CN113396906A (en) * | 2021-06-28 | 2021-09-17 | 白燕波 | Composite quaternary ammonium salt low-temperature disinfectant and preparation method thereof |
| CN114652741A (en) * | 2022-01-19 | 2022-06-24 | 昆明野水生物科技有限公司 | Composition and preparation for inhibiting HPV and application thereof |
| CN114652741B (en) * | 2022-01-19 | 2023-08-25 | 昆明野水生物科技有限公司 | Composition and preparation for inhibiting HPV and application of composition and preparation |
| CN114868762A (en) * | 2022-04-23 | 2022-08-09 | 杭州西子卫生消毒药械有限公司 | Composite intermediate-effect disinfectant and preparation method thereof |
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