CN105055304A - Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof - Google Patents
Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof Download PDFInfo
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- CN105055304A CN105055304A CN201510470114.7A CN201510470114A CN105055304A CN 105055304 A CN105055304 A CN 105055304A CN 201510470114 A CN201510470114 A CN 201510470114A CN 105055304 A CN105055304 A CN 105055304A
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Abstract
The invention belongs to the technical field of disinfectants, and discloses a leave-on skin care and disinfection gel containing a composite sterilization component. The leave-on skin care and disinfection gel is prepared through the following steps: immersing a humectant in deionized water 2 days ahead to dissolve the humectant; stirring and dissolving a thickener in water 1 day ahead; and taking an antibacterial agent at normal temperature, dissolving the antibacterial agent in ethanol, adding a quaternary ammonium salt disinfectant and a biguanide disinfectant, adding the above obtained completely dissolved thickener solution and the obtained dissolved humectant solution, stirring until uniformity, adjusting the pH value to 5.0-7.5 by using a neutralizer, adding deionized water to a full dose, stirring until uniformity, and solidifying. The disinfection gel enlarges the antibacterial spectrum range, is in favor of preventing generation of drug resistant bacteria, has the characteristics of no irritation, quick action and long action, overcomes disadvantages of sing composition disinfectants, and also has a skin care effect.
Description
Technical field
The invention belongs to disinfectant technical field, relate to a kind of disposable skin protection disinfecting gel containing composite bactericidal composition and preparation method thereof.
Background technology
Occurring in nature extensively also exists various microorganism, and some microorganism under certain condition can to human body and environment structure harm.In daily life, people always touch various antibacterial, virus, especially many at some, crowded places, such as bus, subway, public place of entertainment etc.These pathogenic bacterias all cause huge threat to our health and health.The disease caused by cause pathogeny imcrobe infection remains one of chief threat faced in human survival, and often has new pathogen to find, therefore sterilization is still the effective means of fundamental sum the most.Sterilization refers to the method for pathogenic microbe killing, and the medicine in order to sterilization is referred to as disinfectant (Disinfectants).Due to the raising of people's living standard, the enhancing of Personal hygiene and personal protection consciousness, more and more higher to the requirement of sterile products, not only require to sterilize rapidly, safely, have no side effect, the sterile products with contact skin is also required to the effect of skin protection; Along with society and expanding economy, the quickening of people's rhythm of life, require more and more higher to the property of daily articles for use easy to use, its demand also starts to increase sharply, and wherein the disinfectant of gel preparations has become a kind of Personal hygiene sterilizing article be popular with its feature easy to use.
Skin mucosa disinfecting agent is of a great variety in the market, and common skin mucosa disinfecting agent mainly contains ethanol, iodine and povidone iodine, biguanides antibacterial, quaternary ammonium compound, triclosan etc.Wherein:
Ethanol has reliable bactericidal action, wherein the alcoholic solution bactericidal effect of 60.0%-80.0% valid density is best, for clinical the most frequently used concentration, but because its fungicidal spectrum is narrower, killing effect is poor, is used alone the needs that alcoholic solution sterilization can not meet clinical disinfection, and long-time use ethanol bubble hands makes chapped skin coarse and process is loaded down with trivial details, simultaneously volatile because of it, action time is short and limit its use.
Iodine and Iodic agent are by the skin antiseptic of wide clinical application.Clinical conventional Iodic agent mainly iodine is joined, iodine water and povidone iodine.Povidone iodine is current topmost containing iodine skin antiseptic, is the indefinite form complex that iodine and surfactant are combined into.But the color of Operand and cost limit application in daily life.
Biguanides antibacterial has great broad-spectrum antibacterial, bactericidal action, has effect to various bacteria, externally used antimicrobial agent and cationic surfactant, to most gram positive bacteria and gram negative bacteria tool killing action.Except can antibacterial except, also can kill bacteria.Chlorhexidine sterilizing mechanisms, mainly destroy permeability barrier on bacterial cytoplasm film (but not former hypothesis, ATP enzyme lose activity and reach cause bactericidal effect), low concentration can cause part endochylema seepage, high concentration then can cause endochylema cohesion degeneration, thus sterilization.Its advantage be zest compared with other externally used antimicrobial agent be low, seldom there is anaphylactic reaction.Chlorhexidine toxicity is low, zest is little, non-corrosiveness, is applicable to disinfecting of skin mucosa and wound surface, is widely used in the sterilization of mucosa, skin, operation, wound surface, apparatus, apparatus etc.Biguanides antibacterial has good anti-gram positive bacteria effect, more weak to the effect of gram-negative bacteria and fungus, little to Mycobacterium effect, invalid to brood cell.In vitro tests display is as effective in hcrpesviruses, HIV, cytomegalovirus, influenza virus and RSV to there being the virus of film, but obviously as lower in rotavirus, enterovirus and adenovirus effectiveness to the virus without film.
Quaternary ammonium disinfectant is cationic surfactant, has the feature antibacterial such as toxicity is low, zest is little, has a broad antifungal spectrum, can change bacterial cytoplasm membrane permeability, make thalline endochylema extravasation, hinders its metabolism and plays killing action.Their sterilizing powers are strong, have deactivation to fat-soluble virus, to skin with organize nonirritant, to human non-toxic, to metal, the corrosion-free effect of rubber, but exist and are used alone for a long time, and the shortcoming such as easily develop immunity to drugs.
Triclosan is a kind of high-efficiency broad spectrum antibacterial.In the later development sixties in 20th century, for medical personnel and public place in the consumer goods such as cleansing milk, handwashing liquid.U.S. FDAs in 2011 and EPA reappraise the safety of triclosan, come from the product containing triclosan once react with chloride tap water, can form the material that one is called as " chloroform ", i.e. chloroform.Chloroform animal experiment finds, can cause damage, have slight teratogenecity, can induce white mice generation hepatocarcinoma, but there is no the research data of human carcinogen heart and liver.For the sake of assurance, chloroform is all classified as suspect carcinogen human body being had to potential threat by IARC and the U.S..
Therefore the disinfectant that clinical and everyday life uses at present is changed can not meet safety, wide spectrum, efficient, working concentration is low, environmental friendliness, user of service's skin is had to the requirement of protection.
Summary of the invention
Object of the present invention is just to provide a kind of disposable skin protection disinfecting gel containing composite bactericidal composition; This disinfecting gel expands antimicrobial spectrum scope, is beneficial to the generation preventing fastbacteria, nonirritant, can play quick-acting, long-acting feature simultaneously, overcome the shortcoming of single prescription disinfectant, have skin care effect concurrently simultaneously.
The technical scheme realizing the invention described above object is:
Containing a disposable skin protection disinfecting gel for composite bactericidal composition, be made up of the composition of following weight portion:
Quaternary ammonium disinfectant 0.1-0.4
Biguanides disinfectant 0.2-0.5
Anti-antibacterial 0.1-1.0
Wetting agent 1-10
Thickening agent 0.2-0.5
Nertralizer 0.1-1.5
Deionized water 86.3-98.3.
Form above-mentioned containing in the disposable skin protection disinfecting gel of composite bactericidal composition,
---described quaternary ammonium disinfectant comprises strand and double-chain quaternary ammonium salt disinfectant; Wherein, described strand season is geramine or bromo geramine by salt disinfectant, and described double-chain quaternary ammonium salt class disinfectant is octyl decyl dimethyl ammonium chloride, two octyldimethyl ammonium chloride or double-track suspended self-propelled conveyor;
---described biguanides disinfectant is chlorhexidine acetate, chlorhexidine gluconate or poly hexamethylene biguanide;
---described anti-antibacterial is triclocarban;
---described wetting agent is hyaluronate sodium and 1,2 propylene glycol, isopropyl alcohol or PEG400;
---described thickening agent is polyacrylic polymer, gelatin or hydroxyethyl-cellulose;
---described nertralizer is triethanolamine or DL-aminopropanol.
The step preparing the above-mentioned disposable skin protection disinfecting gel containing composite bactericidal composition comprises:
By above-mentioned formula and consumption, wetting agent was immersed in deionized water in 2 days in advance, make it dissolve rear for subsequent use; Within 1 day, thickening agent is stirred soluble in water for subsequent use in advance; Getting anti-antibacterial under room temperature is dissolved in ethanol, add quaternary ammonium disinfectant, biguanides disinfectant, the wetting agent solution adding consoluet thickener soln again and dissolved, after stirring, adjust pH value to 5.0-7.5 with nertralizer, add deionized water again to full dose, stir evenly after coagulation and obtain the disposable skin protection disinfecting gel of the present invention.
Disposable skin protection disinfecting gel containing composite bactericidal composition provided by the present invention, compared with prior art has following advantage:
One, owing to forming in this disposable skin protection disinfecting gel containing triclocarban and hyaluronate sodium; And triclocarban (English name is Triclocarban, be commonly called as trichlorine carbon phthalein aniline, be called for short TCC) be a kind of efficient, broad spectrum antimicrobicide, it possesses lasting, safe, stable sterilization feature, there is the fabulous compatibility with skin, and to gram positive bacteria, gram negative bacteria, fungus, yeast, virus, all there is efficient inhibitory or killing effect; Compare with oxygen system antibacterial with traditional chlorine system, the outstanding advantage of triclocarban (TCC) be stability and compatibility fabulous, there is no niff, and consumption is few, lasting medicine.Even if be diluted to the triclocarban solution of three thousands of times, the growth of some pathogenic bacteria also can be suppressed completely; Hyaluronate sodium is that the excellent natural moisture preserving of generally acknowledging at present moistens cunning dose, has no side effect to skin.In disinfectant, add natural moisture preserving lubricant hyaluronate sodium, it can carry out moisture-keeping function to skin, compensate for usual sterile products causes damage this defect to skin, and life-time service also can make skin smooth, tender; Therefore by the disposable skin protection disinfecting gel that quaternary ammonium salt, biguanide, the application of triclocarban associating prescription are formed, expand antimicrobial spectrum scope, be beneficial to the generation preventing fastbacteria;
Its two, disposable skin protection disinfecting gel has stable in properties, bactericidal effect is good, antibacterial time is long for this, nonirritant, easy to use and have good skin care effect;
Its three, the preparation of this disposable skin protection disinfecting gel has the advantages that technique is simple and production cost is low.
Detailed description of the invention
Embodiment 1
Hyaluronate sodium is immersed in distilled water, make it dissolve for subsequent use, get Acritamer 940 and be dissolved in distilled water, be stirred to and dissolve completely, for subsequent use; Separately get triclocarban to be dissolved in ethanol being stirred to and to dissolve completely, add quaternary ammonium salt, biguanide, add consoluet Acritamer 940 solution again and dissolved complete and filtered sodium hyaluronate solution, stir evenly, pH to 5.0-7.5 is adjusted with triethanolamine, add distilled water again to full dose, stir evenly after coagulation and obtain the disposable skin protection disinfecting gel of the present invention.Fill, in flexible pipe or plastic bottle, is finished product.
Embodiment 2
The disposable skin protection disinfecting gel of the present invention, in l00g, gets geramine 0.2g, chlorhexidine acetate 0.2g, triclocarban 0.1g, 1,2 propylene glycol 5g, hyaluronate sodium 0.03g, Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Embodiment 3
The disposable skin protection disinfecting gel of the present invention, in l00g, gets bromo geramine 0.2g, chlorhexidine gluconate 0.2g, triclocarban 0.1g, 1,2 propylene glycol 5g, hyaluronate sodium 0.03g, Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Embodiment 4
The disposable skin protection disinfecting gel of the present invention, in l00g, gets bromo geramine 0.2g, poly-six subunit biguanide 0.2g, triclocarban 0.1g, 1,2 propylene glycol 8g, hyaluronate sodium 0.03g, Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Embodiment 5
The disposable skin protection disinfecting gel of the present invention is in l00g, get geramine 0.1g, two octyldimethyl ammonium chloride 0.1g, poly-six subunit biguanide 0.2g, triclocarban 0.1g, 1,2 propylene glycol 8g, hyaluronate sodium 0.03g Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Embodiment 6
The disposable skin protection disinfecting gel of the present invention is in l00g, get double-track suspended self-propelled conveyor 0.1g, two octyldimethyl ammonium chloride 0.1g, poly-six subunit biguanide 0.2g, triclocarban 0.1g, 1,2 propylene glycol 8g, hyaluronate sodium 0.03g Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Embodiment 7
The disposable skin protection disinfecting gel of the present invention, in l00g, gets octyl decyl dimethyl ammonium chloride 0.2g, poly-six subunit biguanide 0.2g, triclocarban 0.1g, 1,2 propylene glycol 8g, hyaluronate sodium 0.03g Acritamer 940 0.3g, triethanolamine 0.8g, all the other are distilled water, produce by the method for the invention.
Claims (8)
1., containing a disposable skin protection disinfecting gel for composite bactericidal composition, be made up of the composition of following weight portion:
Quaternary ammonium disinfectant 0.1-0.4
Biguanides disinfectant 0.2-0.5
Anti-antibacterial 0.1-1.0
Wetting agent 1-10
Thickening agent 0.2-0.5
Nertralizer 0.1-1.5
Deionized water 86.3-98.3.
2. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described quaternary ammonium disinfectant comprises strand and double-chain quaternary ammonium salt disinfectant; Wherein, described strand season is geramine or bromo geramine by salt disinfectant, and described double-chain quaternary ammonium salt class disinfectant is octyl decyl dimethyl ammonium chloride, two octyldimethyl ammonium chloride or double-track suspended self-propelled conveyor.
3. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described biguanides disinfectant is chlorhexidine acetate, chlorhexidine gluconate or poly hexamethylene biguanide.
4. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described anti-antibacterial is triclocarban.
5. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described wetting agent is hyaluronate sodium and 1,2 propylene glycol, isopropyl alcohol or PEG400.
6. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described thickening agent is polyacrylic polymer, gelatin or hydroxyethyl-cellulose.
7. a kind of disposable skin protection disinfecting gel containing composite bactericidal composition as claimed in claim 1, is characterized in that: described nertralizer is triethanolamine or DL-aminopropanol.
8. the step preparing the disposable skin protection disinfecting gel of a kind of composite bactericidal composition according to claim 1 comprises:
By the amount of required composition, wetting agent was immersed in deionized water in 2 days in advance, make it dissolve rear for subsequent use; Within 1 day, thickening agent is stirred soluble in water for subsequent use in advance; Getting anti-antibacterial under room temperature is dissolved in ethanol, add quaternary ammonium disinfectant, biguanides disinfectant, the wetting agent solution adding consoluet thickener soln again and dissolved, after stirring, adjust pH value to 5.0-7.5 with nertralizer, add deionized water again to full dose, stir evenly after coagulation and obtain the disposable skin protection disinfecting gel of the present invention.
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| CN201510470114.7A CN105055304A (en) | 2015-08-04 | 2015-08-04 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
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| CN201510470114.7A CN105055304A (en) | 2015-08-04 | 2015-08-04 | Leave-on skin care and disinfection gel containing composite sterilization component, and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106508946A (en) * | 2016-11-30 | 2017-03-22 | 河池市技术开发中心 | Rearing instrument disinfectant containing gluconic acid |
| CN107691475A (en) * | 2017-11-21 | 2018-02-16 | 安徽省伟业净化设备有限公司 | A kind of preparation method of operating room wall body thimerosal |
| EP3403648A1 (en) | 2017-05-17 | 2018-11-21 | Beijing Textile Medical Technology & Development Co., Ltd. | Compound for treating open injury, and preparation method and application thereof |
| CN111150697A (en) * | 2020-03-02 | 2020-05-15 | 达威控股有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
| CN111467249A (en) * | 2020-04-24 | 2020-07-31 | 嘉兴力山明朗生物医药科技有限公司 | Washing-free antibacterial gel and preparation method thereof |
| CN111973629A (en) * | 2020-07-15 | 2020-11-24 | 湖北华冠中科生物药业有限公司 | Wound disinfection flushing fluid and preparation method thereof |
| CN112168730A (en) * | 2020-09-23 | 2021-01-05 | 江苏龙蟠科技股份有限公司 | Alcohol-free guanidine washing-free disinfectant and preparation method thereof |
| CN112190541A (en) * | 2020-09-27 | 2021-01-08 | 安婕妤化妆品科技股份有限公司 | Privacy care gel product |
| CN112358565A (en) * | 2020-11-06 | 2021-02-12 | 万华化学集团股份有限公司 | Core-shell structure hydrophobic modified SAP for alcohol thickening |
| CN113521042A (en) * | 2021-06-28 | 2021-10-22 | 青岛童医生海洋生物科技股份有限公司 | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof |
| CN113599284A (en) * | 2021-07-01 | 2021-11-05 | 安阳崇高纳米材料科技有限公司 | Efficient and stable washing-free disinfectant and preparation method thereof |
| CN113876629A (en) * | 2021-10-27 | 2022-01-04 | 重明鸟新材料(盐城)有限公司 | Wash-free hand sanitizer and preparation method thereof |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106508946A (en) * | 2016-11-30 | 2017-03-22 | 河池市技术开发中心 | Rearing instrument disinfectant containing gluconic acid |
| EP3403648A1 (en) | 2017-05-17 | 2018-11-21 | Beijing Textile Medical Technology & Development Co., Ltd. | Compound for treating open injury, and preparation method and application thereof |
| CN107691475A (en) * | 2017-11-21 | 2018-02-16 | 安徽省伟业净化设备有限公司 | A kind of preparation method of operating room wall body thimerosal |
| CN111150697A (en) * | 2020-03-02 | 2020-05-15 | 达威控股有限公司 | Wash-free antibacterial hand sanitizer and preparation method thereof |
| CN111467249A (en) * | 2020-04-24 | 2020-07-31 | 嘉兴力山明朗生物医药科技有限公司 | Washing-free antibacterial gel and preparation method thereof |
| CN111973629A (en) * | 2020-07-15 | 2020-11-24 | 湖北华冠中科生物药业有限公司 | Wound disinfection flushing fluid and preparation method thereof |
| CN112168730A (en) * | 2020-09-23 | 2021-01-05 | 江苏龙蟠科技股份有限公司 | Alcohol-free guanidine washing-free disinfectant and preparation method thereof |
| CN112190541A (en) * | 2020-09-27 | 2021-01-08 | 安婕妤化妆品科技股份有限公司 | Privacy care gel product |
| CN112358565A (en) * | 2020-11-06 | 2021-02-12 | 万华化学集团股份有限公司 | Core-shell structure hydrophobic modified SAP for alcohol thickening |
| CN113521042A (en) * | 2021-06-28 | 2021-10-22 | 青岛童医生海洋生物科技股份有限公司 | Alcohol-free wash-free virus inactivation disinfectant special for children and preparation method thereof |
| CN113599284A (en) * | 2021-07-01 | 2021-11-05 | 安阳崇高纳米材料科技有限公司 | Efficient and stable washing-free disinfectant and preparation method thereof |
| CN113599284B (en) * | 2021-07-01 | 2024-02-06 | 安阳崇高纳米材料科技有限公司 | Efficient and stable no-clean disinfectant and preparation method thereof |
| CN113876629A (en) * | 2021-10-27 | 2022-01-04 | 重明鸟新材料(盐城)有限公司 | Wash-free hand sanitizer and preparation method thereof |
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