CN111686068A

CN111686068A - Anti-wrinkle skin-activating cream and preparation method thereof

Info

Publication number: CN111686068A
Application number: CN202010382607.6A
Authority: CN
Inventors: 陳正雄; 陳佳琦; 陳玉倩; 陳政治; 劉淑萍; 楊謹豪; 谭文娟
Original assignee: Jourdeness Guangzhou Cosmetics Co ltd
Current assignee: Jourdeness Guangzhou Cosmetics Co ltd
Priority date: 2020-05-08
Filing date: 2020-05-08
Publication date: 2020-09-22

Abstract

The invention relates to an anti-wrinkle skin-activating cream and a preparation method thereof, belonging to the technical field of cosmetics. The invention provides an anti-wrinkle skin-activating cream, the effective components of which comprise an anti-aging agent; the anti-aging agent is selected from at least one of lactobacillus/roselle flower fermentation product filtrate, hydrangea leaf extract, collard leaf extract, lotus flower extract, peony flower extract, palmitoyl tripeptide-5, oligopeptide-1 and palmitoyl pentapeptide-4. The anti-wrinkle skin-activating cream can effectively inhibit the oxidation of skin and the generation of skin wrinkles, and effectively repair damaged epidermal cells; the anti-aging agent and other components such as a skin conditioner, a humectant, an antioxidant, an anti-inflammatory agent and the like are mutually synergistic, so that the anti-aging agent can effectively inhibit aging problems such as wrinkles, looseness and the like, repair damaged epidermis to restore normal metabolism function of skin, block the activity of MMPs, prevent elastin and collagen from being decomposed, and achieve the effect of skin anti-aging.

Description

Anti-wrinkle skin-activating cream and preparation method thereof

Technical Field

The invention relates to an anti-wrinkle skin-activating cream and a preparation method thereof, belonging to the technical field of cosmetics.

Background

Aging is a part of body aging, which is manifested by cutis laxa, thinning, wrinkle formation, gradual increase and deepening, and is one of the most intuitive external manifestations of body aging. Most women consider that environmental factors (including pollution) have important influence on the skin, and the division capability of basal cells gradually decreases with age, the epidermis gradually becomes thinner, the barrier function of the skin is low, and the aging symptoms such as inflammation, dryness, roughness, dry fine lines and the like appear. In the face of these aging symptoms, in addition to ensuring sufficient metabolic capacity through healthy living habits, there is an urgent need for skin care products that can delay aging to help people resist premature aging of the skin.

At present, some anti-aging cosmetics sold on the market are added with various chemical substances, mainly play a role of chemical anti-aging factors, bring some side effects while resisting aging, and are harmful to the skin after long-term use. The development of a safe anti-aging cosmetic with remarkable anti-wrinkle effect meets the market demand and has great significance.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide an anti-wrinkle skin-activating cream.

In order to achieve the purpose, the invention adopts the technical scheme that: an anti-wrinkle skin-activating cream, wherein the effective component of the anti-wrinkle skin-activating cream comprises an anti-aging agent; the anti-aging agent is at least one selected from lactobacillus/roselle (HIBISCUS SABDARIFA) flower fermentation product filtrate, hydrangea (HYDRANGEA MACROPHYLLA) leaf extract, collard (ALCHEMILLA VULGARIS) leaf extract, Nelumbo NUCIFERA flower extract, Paeonia lactiflora (PAEONIA ALBIFLORA) flower extract, palmitoyl tripeptide-5, oligopeptide-1, and palmitoyl pentapeptide-4.

The roselle flower is roselle, and the roselle flower fermentation solution can effectively repair damaged epidermal cells. Roselle flower tea, which is made of roselle flowers native to Africa and calyx, contains a large amount of vitamins, organic acids and minerals, and is a good prescription for maintaining beauty and keeping young. The roselle flower fermentation liquor is prepared by fermenting blossomed roselle by lactic acid bacteria, and is used for solving various skin problems caused by ultraviolet rays.

The hydrangea leaf extract has an anti-inflammatory effect, is leaves of Saxifragaceae plants, contains unique sweet taste, can be used as a sweet flavoring agent to improve the taste of medicinal herbs, and is also called sweet tea. In recent scientific research, health effects of hydrangea leaves such as oxidation resistance, ulcer resistance, allergy resistance and the like are discovered one by one. The Technoble study also demonstrated that the extract from hydrangea leaves has potent efficacy in inhibiting the synthesis of prostaglandin E2, the major inducer of inflammation.

The extract of the collard has the function of antioxidation. The collard is used for treating various gynecological diseases, so that the herbal is particularly beneficial to women and is also commonly used for brewing and making herbal tea. The collard contains abundant flavonoid components, and brings strong antioxidation to the collard. The skin oxidation is the root of various problems such as inflammation, pigmentation, aging and the like, and the skin oxidation is inhibited, so that the skin aging problem can be inhibited, and natural and healthy skin beauty is brought.

The lotus extract provided by the invention can effectively inhibit the accumulation of aged waste substances.

The peony flower extract can effectively block the activity of Matrix Metalloproteinases (MMPs). The peony root is a common Chinese crude drug and has the functions of easing pain, relieving spasm, astringing and relieving, and the extract of the peony flower can bring tightening, elasticity and vigor to the skin by inhibiting excessive decomposition of components such as collagen and elastin which are closely related to the tightness and elasticity of the skin.

As a preferred embodiment of the anti-wrinkle skin-activating cream of the present invention, the anti-wrinkle skin-activating cream further comprises a skin conditioner, an emollient, a moisturizer, a bacteriostatic agent, an antioxidant, an anti-inflammatory agent and other auxiliaries.

As a preferred embodiment of the anti-wrinkle and skin-activating cream according to the present invention, the other auxiliary agents include an emulsifier, a co-emulsifier, a chelating agent, a thickener, a neutralizer, a preservative, an aromatizer, and deionized water.

The preferred embodiment of the anti-wrinkle and skin-activating cream comprises, by weight, 0.001-1% of an anti-aging agent, 0.02-1% of a skin conditioner, 10-20% of an emollient, 6-20% of a humectant, 0.01-1% of a bacteriostatic agent, 0.1-0.5% of an antioxidant, 0.03-0.1% of an anti-inflammatory agent, 1-5% of an emulsifier, 0.5-2.6% of a co-emulsifier, 0.02-0.08% of a chelating agent, 0.1-0.5% of a thickener, 0.033-0.16% of a neutralizer, 1.0-4.0% of a preservative, 0.01-0.3% of an aromatizing agent and the balance of deionized water.

As a preferred embodiment of the anti-wrinkle and skin-activating cream, the anti-wrinkle and skin-activating cream comprises 0.03355% of an anti-aging agent, 0.056% of a skin conditioner, 14.975% of an emollient, 10.86645% of a humectant, 0.02% of a bacteriostatic agent, 0.3% of an antioxidant, 0.50% of an anti-inflammatory agent, 3.0025% of an emulsifier, 1.05% of a co-emulsifier, 0.05% of a chelating agent, 0.305% of a thickening agent, 0.1% of a neutralizing agent, 2.9% of a preservative, 0.1% of an aromatizing agent and the balance of deionized water in percentage by weight.

As a preferred embodiment of the anti-wrinkle skin-activating cream according to the present invention, the skin conditioner is at least one selected from the group consisting of SOPHORA JAPONICA (SOPHORA JAPONICA) extract, yeast fermentation product extract, and BRASSICA CAMPESTRIS (BRASSICA CAMPESTRIS) sterols.

As a preferred embodiment of the anti-wrinkle skin-activating cream according to the present invention, the emollient is at least one selected from caprylic/capric triglyceride, neopentyl glycol diheptanoate, shea butter (butyspermum PARKII), meadowfoam (limnanthes alba) seed oil, cyclopentadimethylsiloxane, cyclohexasiloxane, cetyl palmitate, sorbitan olivate.

In a preferred embodiment of the anti-wrinkle skin cream according to the present invention, the moisturizer is at least one selected from the group consisting of allantoin, glyceryl polyether-26, Undaria pinnatifida extract, 1, 3-propanediol, butanediol, glycerol, dextran, and caproic acid.

As a preferred embodiment of the anti-wrinkle skin cream according to the present invention, the bacteriostatic agent is peach carin phenol;

as a preferred embodiment of the anti-wrinkle skin-activating cream according to the present invention, the antioxidant is at least one selected from tocopherol (vitamin E) and sunflower (helioanthus ANNUUS) seed oil.

The antioxidant can effectively inhibit aging problems such as wrinkle and flabbiness, repair damaged epidermis to restore normal metabolism function of skin, inhibit activity of MMPs to prevent decomposition of elastin and collagen, activate cells to maintain young health state of cells.

As a preferred embodiment of the anti-wrinkle and skin-activating cream, the anti-inflammatory agent is dipotassium glycyrrhizinate.

As a preferred embodiment of the anti-wrinkle skin-activating cream, the emulsifier is cetearyl olive oleate, sorbitan olive oleate and polysorbate-20; wherein cetearyl olive oleate and sorbitan olive oleate are used as raw materials for preparation, and the addition amount of polysorbate-20 is relatively small.

As a preferred embodiment of the anti-wrinkle skin-activating cream, the auxiliary emulsion is cetearyl alcohol.

As a preferred embodiment of the anti-wrinkle skin-activating cream, the chelating agent is disodium EDTA.

As a preferred embodiment of the anti-wrinkle skin-revitalizing cream according to the present invention, the thickener is carbomer; the neutralizing agent is sodium hydroxide.

As a preferred embodiment of the anti-wrinkle skin cream, the preservative is at least one selected from the group consisting of caprylhydroxamic acid, a mixture of 1, 2-hexanediol and 1, 3-propanediol, p-hydroxyacetophenone, caprylyl glycol, dipropylene glycol and a mixture of diformylglycyrrhizic acid.

As a preferred embodiment of the anti-wrinkle skin-activating cream according to the present invention, the fragrance-imparting agent is selected from at least one of sweet orange (CITRUS RETICULATA DULCIS) peel oil, CITRUS (CITRUS RETICULATA) peel extract, basil (ocimum basilicum) oil, spearmint (MENTHA SPICATA) flower/leaf/stem extract, ROSA DAMASCENA (ROSA DAMASCENA) flower oil, pomelo (CITRUS GRANDIS) peel oil, ROSA rugosa (cymopogon martima) oil, lilac (vanillyl fasciata) fruit extract, PELARGONIUM GRAVEOLENS (PELARGONIUM GRAVEOLENS) oil, chamomile (hedamobilis) flower oil, sage (salvinia OFFICINALIS) oil, and BOSWELLIA (BOSWELLIA CARTERII) oil.

In addition, the invention also aims to provide a preparation method of the anti-wrinkle skin-activating cream, which comprises the following steps:

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the emulsification aid, the emulsifier and the skin conditioner, stirring and dissolving, adding the antioxidant, heating, stirring and dissolving to obtain an oil phase;

(2) putting part of deionized water into a container, sequentially adding a chelating agent and a humectant, stirring for dissolving, adding a thickening agent, stirring uniformly, transferring into a heating container for heating, and repeatedly vacuumizing until no bubbles exist to obtain a water phase;

(3) adding the oil phase in the step (1) into a water phase, adding a neutralizer, uniformly stirring, and cooling;

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the anti-aging agent, the preservative and the aromatizing agent, uniformly stirring, cooling, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

As a preferable embodiment of the preparation method, the heating temperature in the step (1) is 75-85 ℃; in the step (2), the heating container is an emulsifying pot, and the heating temperature is 75-85 ℃; in the step (3), the mode of adding the neutralizing agent is a vacuum material sucking mode, the stirring time is 8-10 min, and the temperature for cooling is 45-50 ℃; in the step (4), the temperature for cooling is 25-30 ℃.

Compared with the prior art, the invention has the beneficial effects that:

(1) the anti-wrinkle skin-activating cream contains the anti-aging agent which can effectively inhibit the oxidation of skin and the generation of skin wrinkles and effectively repair damaged epidermal cells; the roselle flower fermentation liquor can effectively repair damaged epidermal cells, the hydrangea leaf extract has an anti-inflammatory effect, the collard extract has an antioxidant effect, the lotus flower extract can effectively inhibit the accumulation of aging waste substances, and the peony flower extract can effectively hinder the activity of Matrix Metalloproteinases (MMPs).

(2) The anti-wrinkle skin-activating cream disclosed by the invention can effectively inhibit aging problems such as wrinkles and looseness through the mutual synergistic effect of the anti-aging agent and other components such as a skin conditioner, a humectant, an antioxidant and an anti-inflammatory agent, repair damaged epidermis to restore normal metabolism function of skin, block the activity of MMPs (MMPs), prevent elastin and collagen from being decomposed and achieve the effect of skin aging resistance.

(3) The anti-wrinkle skin-activating cream disclosed by the invention can activate the acanthon layer of the epidermis layer (cells with acanthon have all the life functions of cells and participate in the production of keratin, strengthen the cells, firmly connect the keratinocytes together, and enable lymphatic vessels to pass through the cells to obtain nutrients between the cells), and the skin can generate an anti-aging effect on the epidermis layer.

Drawings

Fig. 1 is a radar chart of the result of a satisfaction survey of a subject after using the cream for skin thickening, anti-wrinkle and activation provided by the invention.

Fig. 2 is a diagram showing the results of changes in skin moisture content of a subject before and after the subject uses the cream for skin-care, wrinkle-reduction and activation provided by the present invention.

Fig. 3 is a graph showing the results of changes in skin melanin before and after the skin melanin is applied to the cream for skin-thickening, anti-wrinkle, and activation provided by the present invention.

Fig. 4 is a graph showing the results of changes in skin elasticity of a subject before and after the subject uses the cream for reducing wrinkles and activating skin provided by the present invention.

Fig. 5 is a graph showing the result of changes in canthus crow's feet before and after the subject uses the cream for skin-thickening, anti-wrinkle, and activation provided by the present invention.

Fig. 6 is a graph showing the results of changes in under-eye wrinkles before and after the test subject uses the skin-thickening anti-wrinkle activation cream provided by the present invention.

Fig. 7 is a graph showing the results of the change in wrinkle reduction degree before and after the skin-tight wrinkle-resistant activation cream provided by the present invention is applied to a subject.

Fig. 8 is a graph showing the results of changes in the forehead thinning and fine wrinkles before and after the skin-dense anti-wrinkle activation cream provided by the present invention is applied to a subject.

Fig. 9 is a graph showing the results of changes in the degree of thinning of cheeks before and after the skin-thickening anti-wrinkle activation cream provided by the present invention is used by a subject.

Fig. 10 is a radar chart showing the results of a satisfaction survey of the subjects after using the anti-wrinkle activation cream provided in comparative example 1.

Fig. 11 is a graph showing the results of changes in skin moisture content before and after the test subjects used the skin-thickening anti-wrinkle activation cream provided in comparative example 1.

Fig. 12 is a graph showing the results of changes in skin elasticity before and after the test subjects used the anti-wrinkle activation cream provided in comparative example 1.

Fig. 13 is a graph showing the results of changes in skin melanin before and after the test subject used the skin-thickening anti-wrinkle activation cream provided in comparative example 1.

FIG. 14 shows the test sites of test example 1 and test example 2 of the present invention; wherein, the detection positions of cheeks (4R and 4L) correspond to the positions of 4R and 4L in the figure respectively, and the detection position of forehead (R6) corresponds to the position of 6R in the figure.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Example 1

The embodiment of the invention relates to an anti-wrinkle and skin-activating cream, which comprises the following components in percentage by weight as shown in table 1:

TABLE 1

The preparation method of the anti-wrinkle skin-activating cream comprises the following steps:

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the emulsification aid, the emulsifier and the skin conditioner to 80 ℃, stirring and dissolving, then adding the antioxidant and heating, and stirring and dissolving to obtain an oil phase;

(2) putting part of deionized water into a container, sequentially adding a chelating agent and a humectant, stirring for dissolving, adding a thickening agent, uniformly stirring, transferring into a heating container, heating to 80 ℃, and repeatedly vacuumizing until no bubbles exist to obtain a water phase;

(3) adding the oil phase in the step (1) into a water phase, adding a neutralizing agent, stirring for 8min until the mixture is uniform, and cooling to 45 ℃;

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the anti-aging agent, the preservative and the aromatizing agent, uniformly stirring, cooling to 25 ℃, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

Example 2

The embodiment is an anti-wrinkle and skin-activating cream, which comprises the following components in percentage by weight as shown in table 2 below:

TABLE 2

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the emulsification aid, the emulsifier and the skin conditioner to 85 ℃, stirring and dissolving, then adding the antioxidant and heating, and stirring and dissolving to obtain an oil phase;

(2) putting part of deionized water into a container, sequentially adding a chelating agent and a humectant, stirring for dissolving, adding a thickening agent, uniformly stirring, transferring into a heating container, heating to 85 ℃, and repeatedly vacuumizing until no bubbles exist to obtain a water phase;

(3) adding the oil phase in the step (1) into a water phase, adding a neutralizing agent, stirring for 10min until the mixture is uniform, and cooling to 50 ℃;

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the anti-aging agent, the preservative and the aromatizing agent, uniformly stirring, cooling to 30 ℃, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

Example 3

The embodiment of the invention relates to an anti-wrinkle and skin-activating cream, which comprises the following components in percentage by weight as shown in table 3:

TABLE 3

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the emulsification aid, the emulsifier and the skin conditioner to 75 ℃, stirring and dissolving, then adding the antioxidant and heating, and stirring and dissolving to obtain an oil phase;

(2) putting part of deionized water into a container, sequentially adding a chelating agent and a humectant, stirring for dissolving, adding a thickening agent, uniformly stirring, transferring into a heating container, heating to 75 ℃, and repeatedly vacuumizing until no bubbles exist to obtain a water phase;

Example 4

The embodiment of the invention relates to an anti-wrinkle and skin-activating cream, which comprises the following components in percentage by weight as shown in table 4:

TABLE 4

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the emulsification aid, the emulsifier and the skin conditioner to 78 ℃, stirring and dissolving, then adding the antioxidant and heating, and stirring and dissolving to obtain an oil phase;

(2) putting part of deionized water into a container, sequentially adding a chelating agent and a humectant, stirring for dissolving, adding a thickening agent, uniformly stirring, transferring into a heating container, heating to 78 ℃, and repeatedly vacuumizing until no bubbles exist to obtain a water phase;

(3) adding the oil phase in the step (1) into a water phase, adding a neutralizing agent, stirring for 9min until the mixture is uniform, and cooling to 48 ℃;

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the anti-aging agent, the preservative and the aromatizing agent, uniformly stirring, cooling to 27 ℃, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

Comparative example 1

The comparative example is an anti-wrinkle skin-activating cream, and the anti-wrinkle skin-activating cream comprises the following components in percentage by weight as shown in the following table 5:

TABLE 5

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the preservative and the aromatizing agent, uniformly stirring, cooling to 25 ℃, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

Test example 1

In the experimental example, the skin-thickening anti-wrinkle activation cream provided in example 1 of the present invention was subjected to efficacy evaluation, and the skin-thickening anti-wrinkle activation cream provided in example 1 of the present invention was used to perform a two-month test on the efficacy of fine line fading, whitening, moisturizing, skin color brightening, skin elasticity improvement, and the like.

The test method comprises the following steps: the relevant efficacy tests were carried out on 17 subjects before the cream provided by the invention was used for reducing wrinkles and activating skin, and 56 days after the cream was used, and the age distribution of 17 subjects: 10 people aged 30-40 years; 3 people aged 40-50 years; gender of 4 persons 50-60 years old: female 11, male 6. The method for using the skin-tight anti-wrinkle activating cream provided by the invention comprises the following steps: after the face is cleaned, the toning lotion is firstly used, and then a proper amount of the skin-thickening anti-wrinkle activation cream provided by the invention is used for wiping the whole face once in the morning and at night. And (3) testing environment: under the conditions of constant temperature and constant humidity, the temperature is 25 +/-1 ℃, the humidity is 55 +/-5%, the ambient environment is clean, the light music is played, and the test is carried out after the mood of the testee is relieved. And (3) testing time: the skin-thickening anti-wrinkle activation cream provided by the invention is used by a tested person, and then the skin-thickening anti-wrinkle activation cream is used for the tested person on

days

0, 7, 14, 21, 28, 35, 42, 49 and 56. The specific test method is shown in table 6, wherein the specific positions of the cheeks (4R, 4L) and the forehead (R6) of the tested part are shown in fig. 14.

TABLE 6

And (3) test results:

1. the results of examining the satisfaction of five skin improvement items (wrinkle improvement, skin moisture retention improvement, skin brightness improvement, skin elasticity improvement, and no allergy) of the skin-thickening anti-wrinkle activation cream provided in example 1 of the present invention for 2 months are shown in table 7 and fig. 1.

Table 7 results of the survey of satisfaction of the subjects after using the cream for reducing wrinkles and activating muscles provided by the present invention

Efficacy of	Satisfaction (%)
		Wrinkle improvement	85.4
Promote skin moisture retention	90.2
		Improve the brightness of skin	78.6
Improve the skin elasticity	88.8
		Has no allergy	100

As can be seen from table 7 and fig. 1, the satisfaction of 17 subjects who used the cream for reducing wrinkles, moisturizing skin, improving skin brightness, improving skin elasticity, and causing no allergy was 85.4%, 90.2%, 78.6%, 88.8%, and 100%, respectively, after 2 months.

2. Skin moisture content test: the skin moisture content of the skin of the test subjects before use and after 1 month and 2 months using the skin-moisturizing anti-wrinkle activation cream provided in example 1 of the present invention was changed, and the results are shown in table 8 and fig. 2.

Table 8 change in skin moisture content before and after the use of the anti-wrinkle activation cream provided by the present invention by the test subjects

Skin moisture content	The water content of skin can be increased after 1 month	Skin moisture content increase rate after 2 months of use
			Right cheek	21.22％	34.22％
Left cheek	17.12％	28.35％
			Forehead (head)	4.02％	40.19％

As can be seen from table 8 and fig. 2, after the test subject used the cream for skin-whitening, anti-wrinkle and activation provided by the present invention for 1 month, the skin moisture content increase rates of the right cheek, the left cheek and the forehead were 21.22%, 17.12% and 4.02%, respectively, compared to before use; after a tested person uses the skin-thickening anti-wrinkle activation cream provided by the invention for 2 months, compared with the skin before use, the skin moisture content increasing rates of the right cheek, the left cheek and the forehead are respectively 34.22%, 28.35% and 40.19%. Therefore, the skin moisture content can be obviously improved by using the skin-moisturizing anti-wrinkle activation cream provided by the invention, and the skin-moisturizing anti-wrinkle activation cream provided by the invention has a moisturizing effect.

3. Testing of melanin: the results of the changes in skin melanin between the skin of the subject before use and after 1 month and 2 months using the cream for reducing wrinkles and activating provided in example 1 of the present invention are shown in table 9 and fig. 3.

TABLE 9 change in skin melanin of the test subjects before and after the use of the anti-wrinkle activation cream provided by the present invention

Melanin pigment	The reduction rate of melanin in skin after one month of use	The reduction rate of melanin in skin after one month of use
			Right cheek	-3.92％	-3.41％
Left cheek	-3.91％	-2.53％
			Forehead (head)	-0.59％	-2.19％

As can be seen from table 9 and fig. 3, the skin melanin reduction rates of the right cheek, the left cheek and the forehead of the subject were 3.92%, 3.91% and 0.59% respectively after 1 month of the use of the cream for reducing wrinkles and activating skin provided by the present invention; after the skin-tight anti-wrinkle activation cream provided by the invention is used by a tested person for 2 months, the reduction rates of skin melanin of the right cheek, the left cheek and the forehead are respectively 3.41%, 2.53% and 2.19% compared with the skin melanin before the skin-tight anti-wrinkle activation cream is used. Therefore, the skin melanin can be obviously reduced by using the skin-thickening anti-wrinkle activation cream provided by the invention, and the skin-thickening anti-wrinkle activation cream provided by the invention has a good whitening effect.

4. Testing of elasticity: the results of changes in skin elasticity of the subjects before and after 1 and 2 months using the skin-care anti-wrinkle activation cream provided in example 1 of the present invention are shown in table 10 and fig. 4.

TABLE 10 changes in skin elasticity before and after use of the anti-wrinkle activation cream provided by the present invention by the test subjects

Elasticity	Skin elasticity improvement rate after one month of use	Skin elasticity improvement rate after one month of use
			Right cheek	6.62％	10.3％
Left cheek	4.9％	9.68％
			Forehead (head)	1.71％	4.77％

As can be seen from table 10 and fig. 4, after the test subjects used the cream for reducing wrinkles and activating skin provided by the present invention for 1 month, the skin elasticity improvement rates of the right cheek, the left cheek and the forehead were 6.62%, 4.9% and 1.71%, respectively, as compared to those before use; after a subject uses the skin-thickening anti-wrinkle activation cream provided by the invention for 2 months, the skin elasticity improvement rates of the right cheek, the left cheek and the forehead are respectively 10.3%, 9.68% and 4.77% compared with those before use. Therefore, the skin elasticity can be obviously improved by using the skin-thickening anti-wrinkle activation cream provided by the invention, and the skin elasticity can be well improved by using the skin-thickening anti-wrinkle activation cream provided by the invention.

5. And (3) desalting canthus fishtail lines: the results of changes in canthus crow's feet of the eye of the subject before use and using the cream 56 provided in example 1 of the present invention are shown in table 11 and fig. 5.

Table 11 change of canthus fishtail before and after the skin-dense anti-wrinkle activation cream provided by the present invention

Time of day	Volume of	Area of	Depth of field	Area ratio
					Before testing	13,187px³	1,329px²	9px	0.125％
After using for 56d	10,583px³	1145px²	9px	0.108％

Fig. 5A is a diagram of a subject before applying the cream for skin-sealing, anti-wrinkle and activating according to example 1 of the present invention, and fig. 5B is a diagram of a diagram after applying 56 d; as can be seen from fig. 5, in fig. 5B, the fishtail lines of the eye tails of the subject are significantly reduced compared to fig. 5A; as can be seen from table 11, the percentage of fine lines in the corner of the eye was reduced by 13.6% after the test subject used 56d compared to before the test subject used.

6. And (3) fading wrinkles under eyes: the results of changes in the canthus crow's feet of the eye of the subject before use and using the cream 56 provided in example 1 of the present invention are shown in table 12 and fig. 6.

Table 12 change of under-eye wrinkles before and after use of the skin-thickening anti-wrinkle activation cream provided by the present invention

Fig. 6C is a diagram of a subject before applying the cream for skin-sealing, anti-wrinkle and activating according to example 1 of the present invention, and fig. 6D is a diagram of a subject after applying 56D; as can be seen from fig. 6, in fig. 6D, wrinkles under the eyes of the subject are significantly reduced as compared with fig. 6C; as can be seen from table 12, the percentage of fine wrinkles under the eyes was reduced by 22.4% after the test subjects used 56d, compared with before the test subjects used.

7. And (3) fading the wrinkle degree: the results of changes in canthus crow's feet of the eye of the subject before use and using the cream 56 provided in example 1 of the present invention are shown in table 13 and fig. 7.

Table 13 degree of wrinkle reduction before and after the use of the cream for reducing wrinkles and activating skin for skin contact provided by the present invention

Time of day	Volume of	Area of	Depth of field	Area ratio
					Before testing	28,031px³	2,161px²	12px	0.250％
After using 56Day of this product	19,878px³	1,673px²	11px	0.194％

Fig. 7E shows a subject before applying the cream according to example 1 of the present invention for skin-whitening, anti-wrinkle and activating, and fig. 7F shows a subject after applying 56 d; as can be seen from fig. 7, in fig. 7F, the wrinkles on the cheeks of the subject are significantly reduced as compared to fig. 7E; as can be seen from table 13, the fine line area ratio of the cheek of the subject was reduced by 54.9% after 56d use compared with before use.

8. And (3) thinning degree: the results of the changes of the skin-thickening anti-wrinkle activation cream 56d provided in example 1 of the present invention on canthus crow's feet before use are shown in table 14 and fig. 8 and 9.

Table 14 degree of thinning before and after the skin-dense anti-wrinkle activation cream provided by the present invention was used by the test subjects

Time of day	Volume of	Area of	Depth of field	Area ratio
					Before testing	23,461px³	1,825px²	12px	0.474％
After using 56Day of this product	19,323px³	1,572px²	12px	0.408％

Fig. 8J and 9X show a subject before applying the cream according to example 1 of the present invention for skin-thickening, anti-wrinkle and activating, and fig. 8K and 9Y show a subject after applying 56 d; as can be seen from fig. 8 and 9, in fig. 8J compared with fig. 8K, and in fig. 9X compared with fig. 9Y, the forehead and cheek striae of the subject are significantly reduced; as can be seen from table 14, the fine line area ratio of the forehead of the subject was reduced by 13.9% after 56d use compared to before use.

Test example 2

In this test example, efficacy evaluation was performed on the skin-moisturizing and anti-wrinkle activation cream provided in comparative example 1, and the skin moisturizing, melanin, and skin elasticity of the subjects were tested for two months after the skin-moisturizing and anti-wrinkle activation cream of comparative example 1 was applied to the subjects.

The test method comprises the following steps: the relevant efficacy tests were carried out on 10 subjects before the cream of the comparative example, and 56 days after the use, the age distribution of 10 subjects: 6 people aged 25-40 years; 3 people aged 40-50 years; sex of 1 person 50-60 years old: female 8, male 2. The method of using the comparative cream was: after the face is cleaned, the face is wiped with the lotion and then the appropriate amount of the comparative cream is wiped on the whole face once in the morning and at night. And (3) testing environment: under the conditions of constant temperature and constant humidity, the temperature is 25 +/-1 ℃, the humidity is 55 +/-5%, the ambient environment is clean, the light music is played, and the test is carried out after the mood of the testee is relieved. And (3) testing time: after the comparative cream, it was performed on days 0, 28 and 56. The specific test method is shown in table 15, wherein the specific positions of the cheeks (4R, 4L) and the forehead (R6) of the tested part are shown in fig. 14.

Watch 15

And (3) test results:

1. the results of examining the satisfaction of five skin-improving items (wrinkle improvement, skin moisture retention improvement, skin brightness improvement, skin elasticity improvement, and no allergy) of the skin-sealing anti-wrinkle activation cream provided in comparative example 1 for 2 months by the test subjects are shown in table 16 and fig. 10:

table 16 results of the survey of satisfaction of the subjects after using the cream for reducing wrinkles and activating muscles provided in comparative example 1

As is apparent from table 16 and fig. 10, the satisfaction of 10 subjects with respect to wrinkle improvement, skin moisture retention improvement, skin brightness improvement, skin elasticity improvement, and no allergy after 2 months using the skin-thickening anti-wrinkle activating cream provided in comparative example 1 was 42%, 80%, 68%, 48%, and 100%, respectively.

The subjects used the skin-thickening anti-wrinkle activation cream of comparative example 1 for 2 months were clearly more satisfied than those of example 1 (the satisfaction of the skin-thickening anti-wrinkle activation cream of example 1 was 85.4%, 90.2%, 78.6%, 88.8% and 100%, respectively, in the case of improving wrinkles, improving skin moisture, improving skin brightness, improving skin elasticity, and no allergy).

2. Skin moisture content test: the skin moisture content of the subjects before use was varied by 1 month and 2 months from the use of the skin-thickening anti-wrinkle activation cream provided in comparative example 1, and the results are shown in table 17 and fig. 11.

Table 17 skin moisture changes before and after the subjects used the skin-tight anti-wrinkle activation cream provided in comparative example 1

Skin moisture content	The water content of skin can be increased after 1 month	Skin moisture content increase rate after 2 months of use
			Right cheek	14.32％	18.54％
Left cheek	10.12％	11.56％
			Forehead (head)	3.56％	13.68％

As can be seen from table 17 and fig. 11, the skin moisture content increase rates of the right cheek, the left cheek, and the forehead of the subject were 14.32%, 10.12%, and 3.56%, respectively, after 1 month using the skin-thickening anti-wrinkle activating cream provided in comparative example 1, as compared to before use; after the test subjects used the skin-thickening anti-wrinkle activating cream provided in comparative example 1 for 2 months, the skin moisture content increase rates of the right cheek, the left cheek and the forehead were 18.54%, 11.56% and 13.68%, respectively, compared to before use.

The skin moisture content of the test subjects after 1 month or 2 months of the skin-tight anti-wrinkle activation cream of comparative example 1 was significantly lower than that after example 1.

3. Testing of elasticity: the results of changes in skin elasticity of the subjects before and after 1 and 2 months using the skin-thickening anti-wrinkle activation cream provided in comparative example 1 are shown in table 18 and fig. 12.

Table 18 change in skin elasticity of the subjects before and after using the anti-wrinkle activation cream provided by the comparative example

As can be seen from table 18 and fig. 12, the skin elasticity improvement rates of the right cheek, the left cheek, and the forehead were 1.22%, 0.88%, and 0.43%, respectively, after the test subjects used the skin-thickening anti-wrinkle activation cream provided in comparative example 1 for 1 month, compared to before use; after the test subjects used the skin-thickening anti-wrinkle activating cream provided in comparative example 1 for 2 months, the skin elasticity improvement rates of the right cheek, the left cheek and the forehead were 1.97%, 1.37% and 0.75%, respectively, compared to those before use.

The skin elasticity of the tested person is obviously improved by the skin elasticity of the skin after 1 month or 2 months of the skin-tight anti-wrinkle activation cream in the comparative example 1, and the skin elasticity is obviously improved by the skin-tight anti-wrinkle activation cream in the comparative example 1.

4. Testing of melanin: the results of the changes in skin melanin before use and after 1 month and 2 months using the skin-thickening anti-wrinkle activation cream provided in comparative example 1 are shown in table 19 and fig. 13.

Table 19 change of skin melanin of the test subjects before and after the skin-dense anti-wrinkle activation cream provided by the comparative example

Melanin pigment	The reduction rate of melanin in skin after one month of use	The reduction rate of melanin in skin after one month of use
			Right cheek	1.55％	2.78％
Left cheek	0.32％	1.63％
			Forehead (head)	0.12％	0.89％

As can be seen from table 19 and fig. 13, the skin melanin reduction rates of the right cheek, left cheek, and forehead of the test subjects were 1.55%, 0.32%, and 0.12%, respectively, after 1 month using the skin-thickening anti-wrinkle activating cream provided in the comparative example, as compared to before use; after the skin-tight anti-wrinkle activation cream provided by the invention is used by a tested person for 2 months, compared with the skin-tight anti-wrinkle activation cream before use, the reduction rates of the skin melanin of the right cheek, the left cheek and the forehead are respectively 2.78%, 1.63% and 0.89%.

The reduction rate of skin melanin of a subject after 1 month or 2 months of using the skin-thickening anti-wrinkle activation cream of comparative example 1 is significantly lower than the reduction rate of skin elasticity after using example 1.

In summary, the test results of test example 1 and test example 2 show that the satisfaction survey, the skin moisture content, the skin elasticity improvement rate and the skin melanin reduction rate of the subject using the skin-thickening anti-wrinkle activating cream of example 1 are significantly higher than those using the skin-thickening anti-wrinkle activating cream of comparative example 1 for 1 month or 2 months. Further, the anti-wrinkle skin-activating cream can effectively inhibit the oxidation of skin and the generation of skin wrinkles and effectively repair damaged epidermal cells; the anti-aging agent and other components such as a skin conditioner, a humectant, an antioxidant, an anti-inflammatory agent and the like are mutually synergistic, so that the anti-aging agent can effectively inhibit aging problems such as wrinkles, looseness and the like, repair damaged epidermis to restore normal metabolism function of skin, block the activity of MMPs, prevent elastin and collagen from being decomposed, and achieve the effect of skin anti-aging.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. An anti-wrinkle skin-activating cream is characterized in that the effective component of the anti-wrinkle skin-activating cream comprises an anti-aging agent; the anti-aging agent is selected from at least one of lactobacillus/roselle flower fermentation product filtrate, hydrangea leaf extract, collard leaf extract, lotus flower extract, peony flower extract, palmitoyl tripeptide-5, oligopeptide-1 and palmitoyl pentapeptide-4.

2. The anti-wrinkle skin cream according to claim 1, wherein the anti-wrinkle skin cream further comprises skin conditioning agents, emollients, moisturizers, bacteriostats, antioxidants, anti-inflammatory agents and other adjuvants.

3. The anti-wrinkle skin cream according to claim 2, wherein the other auxiliary agents include emulsifiers, co-emulsifiers, chelating agents, thickeners, neutralizing agents, preservatives, perfuming agents and deionized water.

4. The anti-wrinkle and skin-activating cream according to claim 3, which comprises, by weight, 0.001-1% of an anti-aging agent, 0.02-1% of a skin conditioner, 10-20% of an emollient, 6-20% of a humectant, 0.01-1% of a bacteriostatic agent, 0.1-0.5% of an antioxidant, 0.03-0.1% of an anti-inflammatory agent, 1-5% of an emulsifier, 0.5-2.6% of a co-emulsifier, 0.02-0.08% of a chelating agent, 0.1-0.5% of a thickener, 0.033-0.16% of a neutralizer, 1.0-4.0% of a preservative, 0.01-0.3% of an aromatizing agent, and the balance of deionized water.

5. The anti-wrinkle skin-activating cream according to claim 4, wherein the anti-wrinkle skin-activating cream comprises 0.03355% of an anti-aging agent, 0.056% of a skin conditioner, 14.975% of an emollient, 10.86645% of a humectant, 0.02% of a bacteriostatic agent, 0.3% of an antioxidant, 0.50% of an anti-inflammatory agent, 3.0025% of an emulsifier, 1.05% of a co-emulsifier, 0.05% of a chelating agent, 0.305% of a thickener, 0.1% of a neutralizing agent, 2.9% of a preservative, 0.1% of an aromatizing agent and the balance of deionized water, in weight percentage.

6. The anti-wrinkle skin-activating cream according to claim 5, wherein the skin conditioner is at least one selected from the group consisting of sophora flower extract, yeast fermentation product extract, campesterol; the emollient is selected from at least one of caprylic/capric triglyceride, neopentyl glycol diheptanoate, shea butter, meadowfoam seed oil, cyclopentadimethylsiloxane, cyclohexasiloxane, cetyl palmitate, sorbitan olivate oleate; the humectant is at least one selected from allantoin, glyceryl polyether-26, Undaria Pinnatifida extract, 1, 3-propylene glycol, butanediol, glycerol, dextran, and caproic acid; the bacteriostatic agent is peach cariogenic phenol; the antioxidant is selected from at least one of tocopherol and sunflower seed oil; the anti-inflammatory agent is dipotassium glycyrrhizinate.

7. The anti-wrinkle skin cream according to claim 5, wherein the emulsifier is cetearyl olive oleate, sorbitan olive oleate and polysorbate-20; the coemulsifier is cetearyl alcohol; the chelating agent is selected from disodium EDTA; the thickening agent is carbomer; the neutralizing agent is sodium hydroxide; the preservative is at least one selected from caprylyl hydroximic acid, a mixture of 1, 2-hexanediol and 1, 3-propylene glycol, p-hydroxyacetophenone, caprylyl glycol, dipropylene glycol and a mixture of glycyrrhizic acid dimethyl; the aromatizing agent is selected from at least one of sweet orange peel oil, citrus peel extract, basil oil, spearmint flower/leaf/stem extract, rosa damascena flower oil, pomelo peel oil, palmarosa oil, vanilla planifolia fruit extract, geranium oil, chamomile oil, sage oil and mastic oil.

8. The method for preparing the anti-wrinkle skin-activating cream according to any one of claims 1 to 7, comprising the steps of:

(1) weighing the raw materials according to the proportion, mixing and heating the emollient, the bacteriostatic agent, the co-emulsifier, the emulsifier and the skin conditioner, stirring for dissolving, adding the antioxidant for heating, and stirring for dissolving to obtain an oil phase;

(4) and (4) after the step (3) is finished, adding the anti-inflammatory agent, the anti-aging agent, the aromatizing agent and the preservative, uniformly stirring, cooling, stirring again, and vacuumizing until no bubbles exist, thus obtaining the anti-wrinkle skin-activating cream.

9. The method according to claim 8, wherein in the step (1), the heating temperature is 75 to 85 ℃; in the step (2), the heating container is an emulsifying pot, and the heating temperature is 75-85 ℃; in the step (3), the mode of adding the neutralizing agent is a vacuum material sucking mode, the stirring time is 8-10 min, and the temperature for cooling is 45-50 ℃; in the step (4), the temperature for cooling is 25-30 ℃.