CN111450010A

CN111450010A - Composition with anti-aging effect and application thereof in cosmetics

Info

Publication number: CN111450010A
Application number: CN202010379612.1A
Authority: CN
Inventors: 赵冰怡; 丛琳; 李雪竹
Original assignee: Shanghai New Cogi Cosmetic Co ltd
Current assignee: Shanghai New Cogi Cosmetic Co ltd
Priority date: 2020-05-06
Filing date: 2020-05-06
Publication date: 2020-07-28

Abstract

The invention discloses a composition with an anti-aging effect and application thereof in cosmetics, and relates to the technical field of cosmetics, wherein the composition comprises wrapped retinol, retinol palmitate, carnosine, ascorbyl glucoside, nicotinamide, an extract of citrus peel, hydrolyzed sodium hyaluronate, a sodium hyaluronate cross-linked polymer, β -oat glucan and an extract of European horse chestnut seeds.

Description

Composition with anti-aging effect and application thereof in cosmetics

Technical Field

The invention relates to the technical field of cosmetics, in particular to a composition with an anti-aging effect and application thereof in cosmetics.

Background

From the age of 20-25, the skin gradually enters a natural aging state, the aging speed shows a certain difference due to different genetic genes and living habits, and the early-aged manifestation is not obvious at this moment, and reaches the early-aged terminal of about 30 years. In addition to the multiple stresses and environmental pollution from modern society, the primary signs of early age are: the appearance of fine lines, superficial wrinkles and dry lines, obvious skin saccharification phenomenon, yellowing and roughness, pigmentation, dullness and darkness; the moisture content of the horny layer is reduced, and the skin is dry or pores are large and emit oil; the skin defense ability and blood circulation ability are reduced, and the skin is sensitive. The onset of aging manifests itself as a general decline in the condition of the skin, which is not completely the same as the signs of aging, such as wrinkling and atrophy, and requires relief from multiple skin care dimensions.

At present, the major cosmetics in the market are classified into anti-aging and anti-wrinkle cosmetics, whitening and brightening cosmetics, moisturizing cosmetics and soothing cosmetics, and are mainly used for solving a certain key problem. The anti-aging product is mainly used for repairing existing deep wrinkles, and the age range is 35-45 years old; although water supplement is required in all age groups, the main body is 18-28 years old in high-demand stage, and the water content of the stratum corneum is improved; whitening is to build up on the basis of good skin base to whiten the skin; soothing repairs mainly deal with partially sensitive populations. While skin care products for improving the general condition of the skin are relatively few or have poor use effects or high irritation in age groups between 30 and 35 years. Poor effect or irritation is closely related to compatibility of the formula.

Consumers need a cosmetic that prevents aging, is compact, tender, repairs, brightens, balances water and oil, and enhances barriers. The anti-aging is a prevention means for the female to resist aging, and the preparation for resisting aging is made, so that the aging speed can be effectively delayed, and the good appearance can be kept.

Therefore, the development of cosmetics with anti-aging effect has research significance and social significance.

Disclosure of Invention

The technical problem to be solved by the present invention is some of the drawbacks mentioned in the background.

It is a first object of the present invention to provide an active composition having anti-aging efficacy.

The second object of the present invention is to provide a cosmetic containing the anti-premature efficacy composition.

In order to solve the above problems, the present invention proposes the following technical solutions:

in a first aspect, the invention provides a composition with an anti-aging effect, which comprises the following components in parts by weight:

0.5-1 part of wrapped retinol, 0.05-0.1 part of retinol palmitate, 0.01-0.2 part of carnosine, 0.1-2 parts of ascorbyl glucoside, 1-4 parts of nicotinamide, 1-4 parts of citrus peel extract, 0.03-0.1 part of hydrolyzed sodium hyaluronate, 0.05-0.08 part of sodium hyaluronate, 0.01-0.15 part of sodium hyaluronate cross-linked polymer, 1-5 parts of β -oat glucan and 1-3 parts of European horse chestnut seed extract.

The composition with the anti-aging effect is applied to cosmetics with the anti-aging effect.

First, the composition with anti-aging effect provided by the invention realizes the multi-target and multi-dimensional prevention and improvement of various early-aging symptoms.

The phenomenon of early aging occurs due to various factors, with the increase of age, the subcutaneous fat layer becomes thin, the bone retracts, and the area of the skin does not change. The rate of production of collagen and elastic fibers acting as a "scaffold" for the skin slows down, with hollow-outs appearing in the muscle lining. The decomposition of glycosaminoglycan (i.e., sodium hyaluronate) also reduces the water retention capacity of the skin, reduces the water content of the stratum corneum, makes the epidermis rough, shrinks together, and has obvious ravines, namely fine lines and dry lines. When the skin is aged, the metabolism of the skin is too slow, and redundant sugar is dissociated in blood, so that the skin is saccharified and reacts with protein (such as collagen) to generate AGEs (advanced glycation end products), so that the collagen loses the original elasticity, and the skin becomes yellow, loose, dark, aged and glossy, and wrinkles are aggravated. In addition, excessive ultraviolet irradiation is also an important factor of skin aging, and is manifested by not only ultraviolet-induced metalloprotease accelerating the rupture of elastic fibers and collagen fibers, but also stimulating melanocytes to secrete melanin, causing pigmentation of skin, aging and roughness.

For the reasons, the invention preferably selects the retinol and the retinol palmitate as the main body of the anti-wrinkle and anti-fine line combination, and the ascorbyl glucoside is assisted to promote the synthesis of the collagen and the elastic fiber of the basal layer. The vitamin C formed by converting ascorbyl glucoside as vitamin C derivative in human body can stimulate collagen synthesis, and retinol palmitate are converted in human body to form retinoic acid for activity. Retinol has high activity, is sensitive to light and heat, has large skin irritation, and is easy to have red swelling, irritation and desquamation adverse reaction; retinol palmitate is chemically more stable and less irritating than retinol. In the invention, the inulin lauryl carbamate-coated retinol is preferably matched with retinol palmitate, so that the activity preservation period is prolonged, and the skin irritation is reduced.

The carnosine is preferably used as an anti-glycation active substance, the occurrence of glycation reaction can cause skin hardening and wrinkles, and the carnosine can effectively prevent the occurrence of glycation reaction, protect collagen and other structural proteins from being degraded, prevent the skin from yellowing and improve the wrinkles.

According to the invention, nicotinamide is preferably selected to be matched with the citrus peel extract to improve the problem of facial color deposition of skin. The niacinamide not only has the effects of regulating and controlling skin grease secretion and treating acne and pox, but also can reduce the migration of melanin from melanoblast to keratinocytes and accelerate the peeling of the melanin in the keratinocytes; the citrus peel extract can promote keratinocyte to be closely arranged, improve the luminosity of epidermis, tenderize skin and astringe pores. The combination of the two can play the roles of brightening the skin of the face, softening the cutin, conditioning the secretion of grease and tendering the skin.

The preferred ascorbyl glucoside is based on two aspects, on one hand, the ascorbyl glucoside is beneficial to matching and wrapping retinol and retinol palmitate to stimulate the synthesis of collagen and elastic fibers, and on the other hand, the ascorbyl glucoside can reduce the route of melanin and reduce the generation of melanin or reduce the generated melanin so as to lighten the melanin reduction. In addition, ascorbyl glucoside, as a derivative of vitamin C, has higher stability to water, air and heat than vitamin C, and can effectively remove free radicals and prevent aging as an antioxidant after being converted into active vitamin C in vivo.

The β -glucan is extracted from oats, has a linear structure and strong skin permeability, has the effects of effectively preserving moisture, activating immunity and promoting wound healing, has good permeability and anti-inflammation, can relieve skin allergy, can prevent and treat the phenomena of skin erythema, edema, inflammation, allergy and the like, can enhance skin metabolism by activating cathepsin, promotes skin blood circulation, removes edema and promotes excretion, and can effectively improve skin immunity, promote basal circulation and restore facial ruddy complexion by matching the β -glucan and the aesculus hippocastanum extract.

The composition with the anti-aging effect is also specially matched with three sodium hyaluronate with different molecular weights. The small-molecule sodium hyaluronate can permeate into the substrate to supplement glycosaminoglycan lost by substrate aging; the sodium hyaluronate with medium molecular weight is soaked into the horny layer to improve the water content of the horny layer, and the macromolecular sodium hyaluronate forms a soft moisturizing membrane on the epidermis to reduce the water loss. Under the combined action of the three kinds of sodium hyaluronate, the water-retaining property of the skin can be improved.

Based on the above discussion, in order to achieve the anti-aging effect, the composition with the anti-aging effect is applied to the hands from multiple targets of anti-wrinkle, anti-saccharification, anti-oxidation, black fading and brightening, water replenishing and moisture retention, skin refinement, defense enhancement, circulation promotion and toxin expelling and the like, and the anti-aging effect can prevent and improve the symptoms of the early age in multiple dimensions.

Secondly, the composition with the anti-aging effect preferably wraps retinol, is matched with retinol palmitate and is compounded with other components, so that the aim of anti-wrinkle with high effect by low addition is fulfilled.

The anti-wrinkle active substance is firstly the first generation of retinol and the derivative retinol thereof, the retinol has good anti-wrinkle effect but strong irritation, and is not allowed to be added into cosmetics, the derivative retinol still exists with irritation, but slightly reduced, the retinoic acid is still the gold standard for anti-wrinkle, the second generation is collagen and hyaluronic acid which are mainly used in medicine and beauty, medical cosmetic injection of hyaluronic acid and botulinum toxin has instant anti-wrinkle effect but risk, the effect is maintained for only 3-6 months, the operation cost is high, and the substances are coated outside to resist wrinkle and have no effect, the third generation is VC, coenzyme Q10 and astaxanthin which are mainly used in oxidation resistance, cosmetics achieve anti-aging effect on the original skin in an oxidation resistance manner, but do not help to the aging of wrinkles, the fourth generation is polypeptide which is mainly used as ARGIRE L INE (acetyl hexapeptide-8), inulin, raw material has high effect, inulin, because the addition amount of the compound raw material needs to achieve about 3-5%, the formula retinol can achieve the storage life prolonging effect of the palmitic alcohol, the palmitic alcohol is a good preservation period, the antioxidant effect, the palmitic alcohol is obviously improved by using the vitamin A, the antioxidant effect of the palmitic alcohol, the palmitic alcohol is a good, the antioxidant effect, the palmitic alcohol is achieved by adding of a slow-release effect, the palmitic alcohol is achieved by the good effect, the palmitic alcohol is achieved by the good effect, the palmitic alcohol is achieved by the good effect, the palmitic alcohol is achieved by the good effect, the good effect of the palmitic alcohol is achieved by the good effect, the palmitic alcohol is achieved by the good effect of the palmitic alcohol, the palmitic alcohol is achieved by the good effect.

The composition with the anti-aging effect overcomes the irritation caused by independently using the retinol and the retinol palmitate, and has both mildness and high efficiency.

In a second aspect, the present invention provides a cosmetic having anti-aging effect, comprising the composition having anti-aging effect according to the first aspect.

The further technical scheme is that the composition comprises, by weight, 5-25% of the composition with the anti-aging effect of the first aspect, 1-3% of a humectant, 5-10% of a polyhydric alcohol, 1.5-4% of a thickener, 2-3% of an emulsifier, 8-15% of grease, 0.01-0.5% of an antioxidant, 0.1-1% of a preservative and 0.01-0.1% of an aromatic.

The further technical proposal is that the humectant is PCA sodium or bioglycan-1;

the polyalcohol is one or two of glycerol and butanediol;

the thickener is at least one of carbomer, cetostearyl alcohol, SEP L GE L.

The technical scheme is that the grease comprises liquid grease and solid grease.

The further technical scheme is that the liquid oil is three or more of caprylic/capric triglyceride, hydrogenated polyisobutene, pentaerythritol tetraisostearate, di (PPG-3 myristyl ether) adipate and polydimethylsiloxane, and the solid oil is one or two of shea butter and polyglycerol-3 beeswax.

The technical scheme is that the antioxidant is one of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and tocopherol acetate.

The technical scheme is that the preservative is a complex ligand of methylparaben, propylparaben and/or phenoxyethanol and ethylhexyl glycerol.

The further technical scheme is that the emulsifier is at least one of PEG-20 methyl glucose sesquistearate, methyl glucose sesquistearate and TEGO CARE 165.

Compared with the prior art, the invention can achieve the following technical effects:

the composition with the anti-aging effect is prepared by combining retinol and retinol palmitate, assisting ascorbic acid glucoside, promoting synthesis of basal collagen and elastic fibers, preferably wrapping retinol with retinol palmitate, prolonging the active preservation period and reducing the skin irritation, taking carnosine as an anti-saccharification active substance, effectively preventing saccharification reaction, protecting collagen and other structural proteins from degradation, preventing the skin yellowing problem and improving wrinkles, matching nicotinamide with citrus peel extract to improve the skin color deposition problem, improving the skin, softening cutin, conditioning grease secretion and improving the skin effect, compounding β -glucan and European horse chestnut seed extract, resisting the stimulation damage of the external environment to the skin, promoting the basal circulation, recovering the red skin and increasing the water retention of the skin by matching sodium hyaluronate with different molecular weights.

The composition with the anti-aging effect provided by the invention is reasonably matched from different angles, realizes the aim of high-effect anti-wrinkle due to low addition of active substances, and can exert the effect of the active substances to the maximum extent.

The cosmetic with the anti-aging effect provided by the invention contains the composition with the anti-aging effect, has the effects of improving and improving the comprehensive state of skin, and is beneficial to recovering the health state of the skin, resisting the early aging of the skin and delaying the aging.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

FIG. 1 shows the results of an immediate moisturizing efficacy evaluation experiment;

FIG. 2 shows the results of a skin whitening and brightening effect test;

FIG. 3 shows the results of a human trial comprehensive evaluation experiment;

fig. 4 is a wrinkle level evaluation chart.

Detailed Description

The present invention is further illustrated by the following specific examples, which are intended to be illustrative only and not limiting in any way.

Examples 1-3 cosmetic composition formulations having anti-aging efficacy

The cosmetic composition with the anti-aging effect comprises the components of A group, B group, C group and D group. Specifically, the formula is as shown in table 1 by weight percent:

TABLE 1

Examples 1-3 cosmetics having anti-aging effect were prepared as follows:

(1) adding the components of group A into an emulsifying pot, heating to 80-85 deg.C, stirring to dissolve uniformly, and keeping the temperature for 10min to obtain phase A.

(2) Adding the components of group B into an oil phase pot, heating to 80-85 deg.C, and stirring to dissolve completely to obtain phase B.

(3) Slowly adding phase B into phase A at 80-85 deg.C, homogenizing and emulsifying at 3000rpm for 10-15min to obtain stable and uniform material.

(4) Cooling the material body in the step (3) to 50-55 ℃, adding the components in the group C, adjusting the pH value, properly homogenizing for 2-3min, and uniformly stirring and dispersing.

(5) Cooling the component (4) to 35-40 deg.C, adding the components of group D, stirring, and dispersing to obtain cosmetic with anti-aging effect.

Comparative examples 1 to 9 cosmetic composition formulations without anti-aging efficacy

The cosmetic composition without anti-aging effect is divided into A group, B group, C group and D group. Specifically, the formulations of the comparative examples are shown in tables 2, 3, 4 and 5, respectively, in terms of weight percentage.

TABLE 2

TABLE 3

TABLE 4

TABLE 5

The preparation of comparative examples 1 to 9 was carried out in the same manner as in example 1 and will not be described in detail here.

Effect evaluation experiment 1: instant moisturizing efficacy evaluation experiment

The moisturizing effect of the tested product on the skin surface is evaluated by selecting the formula preparations of the embodiment 2 and the comparative example 1 with reference to the light industry standard QB/T4256-. The capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content of the skin.

(1) Experimental methods 30 healthy volunteers, 16 males, 14 females, aged 25-50 years, were incubated at a constant temperature (22. + -. 1 ℃ C.) and a relative humidity of 50. + -.5%, and were rested for 1 hour, and the samples of example 2 and comparative example 1 were applied to the inner side of the forearm (4cm × 4cm) and the inner side of the forearm (4cm × 4cm) of the left hand of the subject in equal amounts, and the hydration level of the skin was measured at 0 hour, 0.5 hour, 1 hour, and 2 hours after the application of the samples, respectively.

(2) An experimental instrument: the skin moisture tester, meter CM825 (Courage + Khazaha, germany).

(3) The experimental results are as follows: remove the maximum and minimum values and remove the average value. The results are shown in FIG. 1. After 2 hours, the moisture value of example 1 was still 43.9%, and the moisture value of comparative example 1 was 34.4%, indicating that sample group A of example 2 had a good immediate moisturizing effect compared to comparative example 1.

Effect evaluation experiment 2: long-acting 24-hour moisturizing efficacy evaluation experiment

(1) Experimental method 30 volunteers of 20-45 years old were rested for 1 hour at 25 + -1 deg.C and 50 + -5% humidity, samples of example 2 and comparative example 1 were applied to the test area at a rate of 3.0 + -0.1 mg/cm 2 using 4cm × 4cm marked on the curved side of the forearm of the left and right hand as the test area, and skin moisture content was measured for the example area and the comparative example area before application and for 0.5h, 1h, 3h, 6h, 12h, and 24h, respectively.

(2) An experimental instrument: skin moisture tester Corneometer CM825 (Courage + Khazaka, Germany).

(3) The experimental results show that the maximum value and the minimum value are removed, the average value is removed, the results are shown in table 6, compared with the comparative example 1, the example 2 has the effect of long-term moisture content increase, the skin moisture content of the example 2 is increased by 77% after being applied for 0.5h, the skin moisture content of the example 2 is increased by 97% after being applied for 1h, and the effect of the example 2 on the skin moisture content can be continuously maintained for 24 h.

TABLE 6 skin moisture content changes

Effect evaluation experiment 3: test of whitening and brightening effects on human skin

(1) The experimental method comprises the following steps of taking a 4cm 854 cm area inside the left and right front arms of 30 volunteers with the age of 20-35 years, 10 males and 20 females as the exclusion conditions according to the inclusion and exclusion standards of 'diagnosis standards and treatment principles of cosmetic contact dermatitis', taking the area of 4cm 854 cm inside the left and right front arms of the volunteers as a tested part, coating one side of the tested part with the experimental part 1, using the tested part 1 time in the morning and evening, applying no cosmetic to the tested part during the experimental period, cleaning the coated part by the tested part in 14 th, 21 th, 28 th, 35 th, 42 th and 56 th days of continuously using the cosmetics, and taking the change of the skin melanin content before and after use as an index for judging whitening and brightening of the anti-premature aging efficacy composition.

(2) An experimental instrument: skin melanin and heme tester Mexameter MX 18.

(3) The experimental results are as follows: the change of melanin content in human skin is shown in FIG. 2. As can be seen from FIG. 2, the skin of comparative example 1 had a reduced melanin content but had no significant change; the melanin content of the skin can be obviously reduced by using the composition in the example 1, and the melanin content is gradually reduced along with the time, and the significant difference exists between the 42 th day and the 56 th day of the experiment, which shows that the composition with the anti-aging effect can reduce the melanin content of the skin, and brighten and whiten the skin.

Effect evaluation experiment 4: human body trial comprehensive evaluation experiment

(1) The experimental method comprises the following steps: the formulations of example 3 and comparative example 1 were selected and the improvement of the skin complex state of the cosmetic composition having anti-aging effect was measured, thereby evaluating the repair and recovery ability of the composition for various pre-aging symptoms. The male and female volunteers total 100, wherein 50 men and 50 women are aged 25-55 years, and the main symptoms are dark complexion, dry skin, haggard face, and obvious fine lines and edema. Groups were randomized into 2 groups of 25 males and 25 females. The control tests of example 3 and comparative example 1 were carried out for each group. The left side face was used in comparative example 1 and the right side was used in example 3, and the volunteers were evaluated for improvement in skin condition after 1 month.

(2) The investigation method comprises the following steps: and (5) questionnaire survey.

(3) The experimental results are as follows: the statistical results are shown in FIG. 3. The human body trial comprehensive evaluation test obviously reflects the effect difference of the example 3 and the comparative example 1 on improving the skin condition of the early-aged people, 80% of the volunteers using the preparation of the example 3 indicate that the skin comprehensive condition is improved, 65% of the volunteers indicate that the dry lines and fine lines are improved, 70% of the volunteers indicate that the fatigue signs are relieved, and the softness, smoothness, uniformity and glossiness of the skin are obviously improved. The composition with the anti-aging effect has the effects of improving and promoting the comprehensive state of the skin and is helpful for recovering the health state of the skin.

Effect evaluation experiment 5: anti-wrinkle effect comparison experiment of anti-wrinkle functional component in the anti-aging composition disclosed by the invention under the condition of same addition amount as that of the traditional anti-wrinkle component

(1) The experimental method comprises the following steps: 60 volunteers are preferably selected by a dermatologist, who uses the eye tails as a target site, and a healthy female or male with wrinkles having a wrinkle level of about 5 (see fig. 4. wrinkle level standard) is requested based on the eye tails. In the case where no perfect match is found in the standard photographs of the respective levels, a median value or a score of 1/4 (e.g., 5.5 or 5.25) may also be given. The groups were divided into 6 groups, and random distribution was required so that there was no significant difference in wrinkle level distribution, eye line condition, and age distribution among the 6 groups, and the average value of the eye line levels of each group of volunteers was 5. 6 groups were applied to the samples of example 1 and comparative examples 5 to 9, respectively. In the same group, the bilateral symmetry part of each volunteer is tested every day, the test subjects with the same wrinkle grade degree are taken as objects, one side is taken as a sample smearing part randomly, and the other side is taken as a non-smearing part randomly. The experimental time is two months.

(2) Wrinkle rating criteria, as in figure 4.

(3) Visual sensation evaluation: scores at the beginning of the test are given by the professional dermatologist according to the standard picture of wrinkle grade at the beginning of the test, so that the grades of six groups of eye wrinkles are averagely divided into 5; after two months of testing, scores were given by the dermatologist for each group of testers according to the standard photograph of wrinkle grade, and the average was calculated.

(4) The experimental results are as follows: the eye print ratings of 6 volunteers are averaged in table 7. The test shows that the wrinkle grade of the examples and the comparative examples is obviously different by adding the same dosage of the anti-wrinkle component, which indicates that the anti-wrinkle component used in the invention is more effective for preventing and improving fine lines and wrinkles under the same dosage.

TABLE 7 volunteer eyeprint rating score

Sample (I)	Example 1	Comparative example 5	Comparative example 6	Comparative example 7	Comparative example 8	Comparative example 9
							Score of	3.75	5.00	4.50	4.25	4.75	4.50

Effect evaluation experiment 6: patch test

(1) The experimental method comprises the following steps: 30 20-45-year-old volunteers were subjected to a rest for 1 hour at a temperature of 25 + -1 deg.C and a humidity of 50 + -5%, and then subjected to an experiment with normal skin on both sides of the back. The spot test adhesive tape release paper is peeled off, and the medicine chamber is placed on a test bench in an upward mode. The spot test objects are arranged from top to bottom, from left to right and marked. The test substances of examples 1, 2, 3 and comparative examples 2, 3 were directly added to the chamber in an amount slightly exceeding half the volume of the chamber (about 0.02g), and it was noted that the spot test substances were not stuck to the edge of the spot tester as much as possible. The spot test adhesive tape added with the spot test substance is longitudinally stuck on normal skin at two sides of the vertebral column from the lower part, and the medicine chambers are lightly pressed one by one to expel air and evenly distribute the test substance. The test site is marked for easy observation. Patch test time: for 48 hours. Observation time: 48 hours after application, the spot test tape was removed first, and the remaining spot test material was removed with a wet soft paper or cotton swab, and the first observation was made at 30 minutes intervals, and the 2 nd and 3 rd observations were made at 72 and 96 hours, respectively. Observations were continued on day 7, if necessary, taking note of the presence or absence of a delayed response.

(2) The spot size rating scale is shown in Table 8.

TABLE 8 Spot rating Scale

(3) The experimental results are as follows: see table 9 for spot data statistics. In examples 1 to 3, no positive reaction occurred; comparative example 2 only contained encapsulated retinol with retinol palmitate, with 3 adverse reactions; in comparative example 3, common retinol is matched with retinol palmitate, and 3 adverse reactions still occur although other combinations are used for assistance; in comparative example 4, common retinol was used in combination with retinol palmitate, and no auxiliary ingredient was used, resulting in 5 adverse reactions and the highest safety risk. The above data show that the examples 1-3 have no adverse reaction to human body, and the composition with anti-aging effect of the present invention has excellent effect, high safety and mildness.

TABLE 9 Spot-paste data statistics Table

Sample (I)	Negative reaction	Suspicious reactions	Weak positive reaction	Strong positive reaction	Very strong positive reaction
						Example 1	30	0	0	0	0
Example 2	30	0	0	0	0
						Example 3	30	0	0	0	0
Comparative example 2	27	2	1	0	0
						Comparative example 3	27	1	1	1	0
Comparative example 4	25	2	2	1	0

In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. The composition with the anti-aging effect is characterized by comprising the following components in parts by weight:

2. Use of the composition having anti-aging effect according to claim 1 in cosmetics.

3. A cosmetic having anti-aging effect, comprising the composition having anti-aging effect according to claim 1.

4. The cosmetic with anti-aging effect according to claim 3, comprising 5 to 25% by weight of the composition with anti-aging effect, 1 to 3% by weight of a humectant, 5 to 10% by weight of a polyhydric alcohol, 1.5 to 4% by weight of a thickener, 2 to 3% by weight of an emulsifier, 8 to 15% by weight of oil and fat, 0.01 to 0.5% by weight of an antioxidant, 0.1 to 1% by weight of a preservative, and 0.01 to 0.1% by weight of a fragrance.

5. The cosmetic with anti-aging effect according to claim 4, wherein the humectant is sodium PCA or biosaccharide gum-1;

the polyalcohol is one or two of glycerol and butanediol;

the thickener is at least one of carbomer, cetostearyl alcohol, SEP L GE L.

6. The cosmetic having an anti-aging effect according to claim 4, wherein the oil comprises a liquid oil and a solid oil.

7. The cosmetic having an anti-aging effect according to claim 6, wherein the liquid oil is three or more of caprylic/capric triglyceride, hydrogenated polyisobutene, pentaerythritol tetraisostearate, di (PPG-3 myristyl ether) adipate and polydimethylsiloxane, and the solid oil is one or two of shea butter and polyglycerol-3 beeswax.

8. The cosmetic having an anti-aging effect according to claim 4, wherein the antioxidant is one of pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and tocopherol acetate.

9. The cosmetic having an anti-aging effect according to claim 4, wherein the preservative is methylparaben, propylparaben and/or a complex of phenoxyethanol and ethylhexylglycerin.

10. The cosmetic having an anti-aging effect according to claim 4, wherein the emulsifier is at least one of PEG-20 methylglucamine sesquistearate, TEGO CARE 165.