CN115154375A - Stable cleaning composition with repairing and relieving effects - Google Patents
Stable cleaning composition with repairing and relieving effects Download PDFInfo
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- CN115154375A CN115154375A CN202210993168.1A CN202210993168A CN115154375A CN 115154375 A CN115154375 A CN 115154375A CN 202210993168 A CN202210993168 A CN 202210993168A CN 115154375 A CN115154375 A CN 115154375A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a stable cleaning composition with repairing and relieving effects, which comprises the following components in parts by weight: 10-30 parts of caprylic/capric triglyceride, 1-10 parts of PEG-20 glycerol triisostearate, 1-8 parts of mastic extract, 1-7 parts of tripeptide-1 copper, 1-10 parts of camellia seed oil, 1-10 parts of jojoba seed oil, 1-10 parts of avocado oil, 8-15 parts of shea butter, 4-16 parts of jatropha wax and 1-10 parts of rose hip oil. The composition disclosed by the invention can effectively clean the face skin and the body skin, can effectively repair and relieve the skin state without causing damage to the skin while cleaning the skin, protects the barrier of the skin, and is different from other cleaning substances which can damage the original barrier of the skin or thin the horny layer during cleaning. Can solve the problems of skin cosmetic residue, dirt adhesion, incomplete cleaning and the like.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a stable cleaning composition with repairing and relieving effects.
Background
After a large amount of color cosmetics stay on the skin, the color cosmetics easily bring burden to the metabolism of the skin and delay the updating time of the color cosmetics. Especially in the eye, the appearance of aging is very pronounced, and over time the skin becomes aged and develops fine lines. In addition to accelerating aging, color cosmetics also deposit a large amount of pigment on the skin, which may eventually lead to a deepening of the color of the lips and even the color of the eyelids, and the skin color is remarkably deepened after a long time. For people who make up frequently, the common facial cleanser cannot clean the makeup residues on the skin, so that the condition of the skin is greatly changed, and the skin is dark and striking in a large oil field and acne muscles. Therefore, the skin is primarily cleaned, the deep cleaning is not thorough, and the skin care product cannot be well absorbed subsequently.
Skin care products and cosmetics are different in nature, the skin absorbs nutrients in the skin care products and is healthier and healthier, but if too much chemicals in the cosmetics with heavy texture are absorbed, pores are blocked, and the skin cannot permeate air gradually, so that the phenomena of acnes and large pores are caused. The makeup product has the advantages that the makeup product can immediately play the roles of skin color modification and flaw covering when being coated on the face, but the makeup product has good skin grinding effect and high pigment content, if makeup is not removed for a long time, the pigment in the makeup product can be deposited on the skin, the skin color slowly becomes dull and yellow, and the aging sign is generated.
Therefore, the design of the repairing and relieving cleaning formula is based on the dual effects of repairing and relieving the skin, and does not damage the skin and the skin barrier on the basis of cleaning the skin. For people who make up frequently and have incomplete cleaning, it is important to develop a composition which can clean the skin thoroughly and has no damage, repair and relieving effects on the skin.
Disclosure of Invention
The invention aims to provide a stable cleaning composition with repairing and relieving effects, which can effectively clean skin, repair damaged skin and relieve skin sensitivity.
The invention adopts the technical scheme that the stable cleaning composition with repairing and relieving effects comprises the following components in parts by weight: 10-30 parts of caprylic acid/capric acid triglyceride, 1-10 parts of PEG-20 glycerol triisostearate, 1-8 parts of mastic extract, 1-7 parts of tripeptide-1 copper, 1-10 parts of camellia oil and 1-10 parts of jojoba oil.
The present invention is also characterized in that,
preferably, the composition also comprises 1-10 parts of avocado oil and 8-15 parts of shea butter.
Preferably, the composition also comprises 4 to 16 parts of jatropha wax and 1 to 10 parts of rose hip oil.
Preferably, the cleaning composition with the functions of repairing and relieving comprises the following components in parts by weight: 15-25 parts of caprylic acid/capric acid triglyceride, 2-8 parts of PEG-20 glycerol triisostearate, 2-7 parts of mastic extract, 2-6 parts of tripeptide-1 copper, 2-8 parts of camellia oil and 2-8 parts of jojoba oil.
Preferably, the cleaning composition with the functions of repairing and relieving comprises the following components in parts by weight: 16-22 parts of caprylic/capric triglyceride, 3-7 parts of PEG-20 glycerol triisostearate, 3-6 parts of mastic extract, 3-6 parts of tripeptide-1 copper, 3-7 parts of camellia seed oil, 3-7 parts of jojoba seed oil, 2-8 parts of avocado oil and 9-13 parts of shea butter.
Preferably, the stable cleaning composition with repairing and relieving effects comprises the following components in parts by weight: 16-22 parts of caprylic/capric triglyceride, 3-7 parts of PEG-20 glycerol triisostearate, 3-6 parts of mastic extract, 3-6 parts of tripeptide-1 copper, 3-7 parts of camellia seed oil, 3-7 parts of jojoba seed oil, 2-8 parts of avocado oil, 9-13 parts of shea butter, 5-15 parts of jatropha wax and 2-8 parts of rose hip oil.
The invention has the beneficial effects that:
the composition disclosed by the invention can effectively clean the facial skin and the body skin, can effectively repair and relieve the skin state without damaging the skin while cleaning the skin, protects the barrier of the skin, and is different from other cleaning substances which can damage the original barrier of the skin or thin the horny layer during cleaning. Can solve the problems of skin cosmetic residue, dirt adhesion, incomplete cleaning and the like.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
The stable cleaning composition with repairing and relieving effects can be used as an additive of skin care cleaning products to be added into skin care cleaning products such as makeup removing cream, bath cream, cleaning gel and the like. The selection and preparation of the other ingredients of the skin care product can be carried out according to conventional procedures in the art during production.
The caprylic/capric triglyceride in the composition of the invention is clear to light yellow, is highly refreshing and tasteless grease, and belongs to palm oil or coconut oil derivatives. It is an excellent moisturizing oil, has good spreadability, and can make skin feel smooth but not greasy, and be easily absorbed by skin. Has good effect on the uniformity and the fineness of cosmetics and can ensure that the skin is smooth and glossy. Because of the compatible characteristic with human skin, the oil-free skin-care oil has the advantages of non-greasy texture, lubricating and skin-softening effects, and the function of filtering ultraviolet light, and is a natural vegetable oil. Has been proved to be non-irritating to the human body and not to block pores. Caprylic/capric triglyceride is stable, can be stored for more than 6 months after being unsealed, and is widely applied to industries such as food, medicine, cosmetics and the like.
PEG-20 glyceryl triisostearate is a surfactant frequently used in makeup removing products, and has the greatest advantages of high emulsifying speed, low irritation, good makeup removing capability and no residual feeling after washing. Has excellent makeup removing capability, excellent self-emulsifying performance, mildness and no irritation. Is an emulsifier derived from isostearic acid, and is not easy to cause irritation to skin. Compared with oleic acid derivatives, the oleic acid derivative has higher oxidation stability. Freezing resistance, no turbidity at high and low temperatures and no precipitation, and is suitable for transparent formulations. Has strong makeup dissolving capacity and good makeup removing effect, and is suitable for removing makeup.
The boswellia resin extract in the composition is a yellow white powdery liquidity extract product of resin of boswellia carterii of the family Burseraceae, and is a natural source raw material. The boswellia resin extract has the main functions of controlling oil and resisting seborrhea, an anti-inflammatory agent and an antioxidant in cosmetics and skin care products, is relatively safe, and does not cause acne. The compound has good activation effect on a peroxidase-activated receptor, plays an important role in the healing process of skin injury, and has good anti-inflammation; can enhance lipase activity, is helpful for fat decomposition, and can be used in weight-reducing products or washing products for oily skin; promoting activation of caspase, prolonging cell life, and resisting aging; is suitable for tightening skin, oily skin, non-pigmented skin, wrinkle skin, pigmented skin, dry skin, and sensitive skin. The skin care product can be well fused with skin fat and cosmetics in the aspect of cleaning, further thoroughly takes away skin impurities and dirt in the cleaning stage, is not residual, is also suitable for sensitive skin, simultaneously regulates the greasiness of the skin, and has better anti-inflammation and protection effects on damaged skin or sensitive skin. These properties make up for the deficiency and the blank of the cleaning products in repairing and protecting the skin, not only pay attention to the cleaning effect, but also repair, relieve and protect the related problems, such as barrier damage, sensitivity and the like, which can occur when the skin is cleaned.
The tripeptide-1, also known as a dermal growth factor, in the composition of the present invention acts primarily on the dermal layer of the skin, and can promote the synthesis of extracellular matrix such as collagen and glycosaminoglycan, strengthen the dermal layer, make the skin thicker and firmer, smooth wrinkles, and provide greater resistance to ultraviolet radiation. In addition, the tripeptide-1 can convey various functional components to the bottom layer of the skin through a liposome conduction system, so that the formation of new fat cells is prevented. The main function of the anti-oxidant in cosmetics and skin care products is an antioxidant, the risk coefficient is 1, and the anti-oxidant is relatively safe and has no pox-causing property. Has effects in promoting the production of collagen, elastin, hyaluronic acid, etc., resisting aging, removing wrinkle, and caring skin. Tripeptide-1 is a signal peptide, and has effects in promoting the production of proteoglycan such as type I and III collagen, elastin, structural glycoprotein such as laminin and chemical fibronectin, promoting wound repair and mechanism upgrade and reconstruction, and promoting subcutaneous tissue, so that skin is firmer and firmer, and wrinkles are relieved. Can reasonably prevent and fade wrinkles, and make the skin younger, smoother and malleable.
Tripeptide-1 copper, also known as trispetide copper peptide, bluecopper peptide. The cosmetic and the skin care product mainly have the effects of moisturizing agent, antioxidant and anti-inflammatory agent, and have no pox-causing property. The copper peptide and the copper compound thereof can be used as an activator and an antioxidant for tissue remodeling, and the copper peptide is also a signal peptide, so that the degradation of a large number of collagen aggregates outside the scar, the synthesis of normal collagen of the skin, the generation of elastin, proteoglycan and glucosaminan, the growth speed and migration of different cell types, inflammation resistance and antioxidant reaction are promoted. The product can effectively promote the production of collagen and elastin, and has antioxidant and antiaging effects. The tripeptide-1 and the tripeptide-1 copper supplement each other, and provide repairing, relieving and antioxidant effects for various aspects of the cleaning composition. The skin-cleaning product breaks through the single cleaning concept of the traditional skin-cleaning products, provides beneficial effects on the skin as far as possible while cleaning, can not supplement nutrition in a short time, but can ensure that the skin is cared at no time and the original nutrition is not lost.
The camellia seed oil in the composition is extracted from the camellia fruit of the wild woody oil plant, and has good health care effect on skin. Unsaturated fatty acid, also called 'cosmetic acid', and the unsaturated fatty acid content in camellia oil is up to 93%, in fact, the base oil of cosmetics is made of tea oil and olive oil, and only the two oils can be used as the base oil of cosmetics, because the nutrients contained in the two oils are needed by human body and can be directly absorbed by skin. Only tea oil can be eaten and can also be used as cosmetics, and can also be used as essential oil to be combined with other nutritional ingredients to be absorbed through skin. Camellia seed oil is obtained from camellia seeds by cold pressing and solvent extraction methods, and contains various physiological active substances such as abundant monounsaturated and polyunsaturated fatty acids, squalene, vitamin E, phytosterol, camellia saponin, tea polyphenol, flavonoid compounds and the like. The skin-friendly tea has good skin-friendly property, can quickly permeate into skin, supplement antioxidant substances such as unsaturated fatty acid, squalene, vitamin E, polyphenol and flavonoid compounds, directly remove harmful active oxygen and active nitrogen, and promote synthesis of antioxidant enzymes and antioxidant substances of cells; the camellia seed oil is rich in substances such as tea polyphenol, vitamin E and the like, the content of the substances is higher than that of olive oil, and the substances can obviously inhibit tyrosinase activity, so that melanin synthesis is reduced, and the effects of removing freckles and whitening are achieved; in addition, tea polyphenols can promote the growth of skin horny cells, maintain the proliferation cycle of cells, and inhibit the apoptosis of normal skin horny cells, thereby delaying aging. In conclusion, the camellia oil contains rich nutrient substances, so that the camellia oil has good effects of antioxidation, anti-inflammation, repair, whitening and the like, and is a natural cosmetic raw material with great potential.
The jojoba seed oil in the composition is a native plant of mexican, has good permeability and has the characteristic of high temperature resistance. Jojoba seed oil has a chemical molecular arrangement very similar to that of human sebum, and is very easily assimilated and assimilated by skin. Strictly speaking, the jojoba seed oil is waxy but not liquid, can be coagulated when meeting cold, can be immediately melted and absorbed by skin when contacting the skin, has very remarkable beautifying effect on the skin, can be used for smoothing pores, regulating the grease secretion of oily or mixed skin, and improving skin inflammation and sensitivity, eczema, psoriasis, pimple and the like, has the other characteristic of hydrophilicity, has the function of regulating moisture on the skin, and is a good natural skin-care component. Jojoba seed oil provides two layers of action on the skin: quickly penetrate and absorb and soften skin cutin, so that the skin becomes soft and elastic. Has obvious skin beautifying effect, can dredge capillary pores, regulate the oil secretion of oily or mixed skin, and improve inflamed skin, eczema, psoriasis, pimple, etc. It has good therapeutic effect on allergic skin, and can restore activity and luster of dry wrinkle skin. Contains important natural vitamins of the skin, collagen protein with high nourishing degree and mineral substances, can massage and protect the skin, avoid water loss, nourish and deeply care the skin, enable the skin to be glossy and elastic, and relieve the damage of wind, wind and sun to the skin.
The avocado oil in the composition is base oil with high nutritive value, has the characteristic of moistening grease, and is very suitable for dry skin. Especially, extremely dry skin is suitable for dry, fragile, sunned and swollen skin due to the fact that the extremely dry skin contains vitamin D which is higher than that of eggs, skin elasticity, water loss and elasticity lack are increased, and hair growth is promoted. The penetration force of the avocado oil is second to that of the jojoba oil, and the avocado oil can be applied to the skin to clean the deep layer of the skin, eliminate wrinkles, fade black spots and freckles, and is suitable for people with neutral, dry and sensitive skin. The avocado oil and the jojoba seed oil can be used in a matching way, and the penetration force of the avocado oil and the jojoba seed oil is enhanced by combined use, so that the avocado oil is a very good natural antioxidant. The avocado oil also contains a large amount of vitamin E, witch hazel and lecithin, and can help skin to increase resistance, moisten and moisturize skin, easily permeate skin and have anti-aging effect.
The shea butter in the composition is natural grease extracted from the fruit of the shea butter, the mass fraction of unsaponifiable matters in the shea butter is as high as 9-13%, and the natural moisturizing factors in the shea butter and the moisturizer extracted from the sebaceous glands have the same components, so that the shea butter is a natural vitamin A cream, and is considered as the most effective natural skin moisturizer and conditioner. The shea butter contains cinnamate, and can be used in sunscreen cosmetic for preventing skin injury caused by ultraviolet radiation, and natural emulsion in shea butter can prevent skin allergy caused by sunlight radiation. The avocado fat can promote cell regeneration and capillary circulation, and can be used in skin care products for preventing and delaying skin aging. The shea butter has strong water locking capacity and good affinity to skin, and the vitamin A in the shea butter has important improvement effect on removing a plurality of skin defects such as wrinkles, eczema and the like. The skin care product containing the shea butter can be effectively utilized in skin care products and beauty products, has extremely high moisturizing factors, and can achieve long-acting moisturizing effect for 6 hours if the skin is dry or has dry climate, so that the skin is in a moist and smooth state for a long time, the grease which is lacked in epidermal cells of a human body can be supplemented, and various basic elements which are needed for maintaining the physiological balance of the skin can be provided.
The wild lacquer fruit wax in the composition is a pure natural plant wax which is squeezed from the fruit peel of a lacquer tree, the main component of the wild lacquer fruit wax is C16-18 fatty glyceride, the chemical structure determines the soft characteristic of the wild lacquer fruit wax, the wild lacquer fruit wax can generate very smooth texture, the texture of an oil-in-water emulsion is greatly improved, and the linoleic acid content is up to more than 60 percent. The jatropha wax has fine crystals and contains the dibasic acid glyceride, so that the jatropha wax has fine texture, seepage force, viscosity and toughness and smooth feeling which are not possessed by common fat, and can endow the product with gloss feeling. Can increase the adhesion degree among the components of the product, improve the fluidity of the product, adjust the stability of the product and improve the quality of the product.
The rose-hip seed oil is rose-shrub seed, has the main effective components of vitamin A and vitamin C, has an anti-aging effect, promotes skin rejuvenation, increases skin elasticity, and is tight and moist. Has proliferation activity on vascular endothelial cells, can enhance the strength of blood vessels, and can prevent red blood streak of skin; inhibiting elastase, resisting wrinkle, and resisting aging, and can be used in cosmetics with SOD-like activity. The addition of the lacca wax and the rose hip seed oil enables a formula system to be more stable, the cleaning composition not only has certain cleaning power under the multi-effect condition of natural vegetable oil, but also has the effect of relieving and repairing compared with the prior cleaning power under the condition of mutual cooperation of various substances, and meanwhile, the problem that many previous cleaning skin care products are not considered is solved on the basis, and the synergistic effect is far stronger than the combined effect of the two.
Caprylic/capric triglyceride of the present invention is purchased from Croda Singapore Pte Ltd, PEG-20 glyceryl triisostearate is purchased from Shanghai Noke Kogyo, boswellia resin extract is purchased from Shanghai Rui xi trade Co., ltd, avocado oil is purchased from Shanghai Capsella Biotech Co., ltd, butyrospermum parkii fruit fat is purchased from Ashucal oil (Zhang Jia) Co., ltd, paraja wax is purchased from Henan Fumei Biotech Co., ltd, camellia oil is purchased from Shanghai Kubei Biotech Co., ltd, jojoba oil is purchased from Vantage Specialty Chemicals, inc. Russian rose oil is purchased from Northstar Lipids (UK) LTD.
The tripeptide-1, also called GHK tripeptide, adopted by the invention is produced by Shaanxi Huikang biological science and technology Limited liability company;
the preparation method of the tripeptide-1 copper adopted by the invention comprises the following steps: adding GHK tripeptide into purified water, wherein the mass ratio of the GHK tripeptide to the purified water is 1:1, then adding copper acetate (the mass of the copper acetate is 3 times of that of GHK tripeptide), adjusting the pH value to 8.0, reacting for 2-3 hours, and filtering impurities; concentrating to obtain oil, adding anhydrous ethanol, stirring, adding ethyl acetate, stirring, filtering to obtain wet GHK-Cu, drying, and pulverizing to obtain GHK-Cu (tripeptide-1 copper).
The caprylic/capric triglyceride in the compositions of the present invention provides a fresh skin feel in the cleansing composition as a natural solvent; PEG-20 glyceryl triisostearate is used as a nonionic surfactant in the cleaning composition, has mild property and low irritation to skin; mastic resin extract as a skin conditioner in a cleansing composition for enhancing lipase activity, aiding lipolysis, and removing excess oil from the skin in the cleansing composition; tripeptide-1, have antioxygenic property, have effects of promoting the production of collagen, elastin, hyaluronic acid, etc., it has effects of resisting aging, resisting wrinkle and revitalizing the skin; tripeptide-1 copper, which is effective in promoting the production of collagen and elastin in a cleaning composition, and has antioxidant and anti-aging capabilities; the camellia oil has good skin-friendly property, can quickly permeate into the skin in the cleaning composition, supplements antioxidant substances such as unsaturated fatty acid, squalene, vitamin E, polyphenol, flavonoid compounds and the like, directly eliminates harmful active oxygen and active nitrogen, and can promote the synthesis of antioxidant enzymes and antioxidant substances of cells; the camellia seed oil is rich in substances such as tea polyphenol, vitamin E and the like, the content of the substances is higher than that of olive oil, and the substances can obviously inhibit tyrosinase activity, so that melanin synthesis is reduced, and the effects of removing freckles and whitening are achieved; in addition, the tea polyphenol can promote the growth of skin keratin cells, maintain the proliferation cycle of the cells, and inhibit the apoptosis of normal skin keratin cells, thereby delaying the aging; jojoba seed oil is used as a moistening agent and a humectant in the cleaning composition, has the characteristics of difficult oxidation, high temperature resistance, high pressure resistance, small viscosity change and the like, has better touch and extensibility than other vegetable oil, can make skin soft and elastic, and is easy to be absorbed by the skin; avocado oil, which is highly permeable to the skin and is used as a carrier for a variety of substances; has surface activity, mild action on skin, good softening and sterilizing effects and certain sun-screening performance; the shea butter is used as a natural skin humectant and conditioner in the cleaning composition, has stronger water locking capacity and good affinity to the skin; the lacca wax is used as a binder in the cleaning composition, so that the binding degree among product components can be increased, the product has enough strength, meanwhile, the fluidity of the product can be improved, the stability of the product can be adjusted, and the quality of the product can be improved; the Rosa rustica seed oil can be used as emollient in cleaning composition, has proliferation activity on vascular endothelial cells, can enhance blood vessel strength, and can prevent red blood streak on skin.
Example 1
The stable cleaning composition with repairing and relieving effects comprises the following components: 20g caprylic/capric triglyceride, 1g PEG-20 glycerol triisostearate, 0.7g boswellia resin extract, 0.5g tripeptide-1, 1.5g tripeptide-1 copper, 2g camellia seed oil and 2g jojoba seed oil.
Example 2
The stable cleaning composition with repairing and relieving effects comprises the following components: 22g caprylic/capric triglyceride, 3g PEG-20 glycerol triisostearate, 0.9g boswellia resin extract, 0.7g tripeptide-1, 1.7g tripeptide-1 copper, 4g camellia seed oil and 4g jojoba seed oil.
Example 3
The stable cleaning composition with repairing and relieving effects comprises the following components: 24g caprylic/capric triglyceride, 5g PEG-20 glycerol triisostearate, 1.2g boswellia resin extract, 0.9g tripeptide-1, 2g tripeptide-1 copper, 6g camellia seed oil and 6g jojoba seed oil.
Example 4
The stable cleaning composition with repairing and relieving effects comprises the following components: 26g caprylic/capric triglyceride, 7g PEG-20 glycerol triisostearate, 1.5g boswellia resin extract, 1.2g tripeptide-1, 4g tripeptide-1 copper, 8g camellia seed oil and 8g jojoba seed oil.
Example 5
The stable cleaning composition with repairing and relieving effects comprises the following components: 28g caprylic/capric triglyceride, 9g PEG-20 glyceryl triisostearate, 2g boswellia resin extract, 1.5g tripeptide-1, 6g tripeptide-1 copper, 10g camellia seed oil and 10g jojoba seed oil.
Example 6
The stable cleaning composition with repairing and relieving effects comprises the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of boswellia extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia oil, 2g of jojoba oil, 2g of avocado oil and 3g of shea butter.
Example 7
The stable cleaning composition with repairing and relieving effects comprises the following components: 23g of caprylic/capric triglyceride, 4g of PEG-20 glycerol triisostearate, 1g of boswellia extract, 0.8g of tripeptide-1, 1.8g of tripeptide-1 copper, 5g of camellia oil, 5g of jojoba oil, 3g of avocado oil and 4g of shea butter.
Example 8
The stable cleaning composition with repairing and relieving effects comprises the following components: 25g caprylic/capric triglyceride, 6g PEG-20 glyceryl triisostearate, 1.3g boswellia extract, 1.1g tripeptide-1, 3g tripeptide-1 copper, 7g camellia oil, 7g jojoba oil, 4g avocado oil, 6g shea butter.
Example 9
The stable cleaning composition with repairing and relieving effects comprises the following components: 28g caprylic/capric triglyceride, 9g PEG-20 glyceryl triisostearate, 2g boswellia extract, 1.5g tripeptide-1, 6g tripeptide-1 copper, 10g camellia oil, 10g jojoba oil, 6g avocado oil, 8g shea butter.
Example 10
The stable cleaning composition with repairing and relieving effects comprises the following components: 20g of caprylic/capric triglyceride, 1g of PEG-20 glycerol triisostearate, 0.7g of boswellia resin extract, 0.5g of tripeptide-1, 1.5g of tripeptide-1 copper, 2g of camellia oil, 2g of jojoba oil, 10g of jatropha wax and 2g of rose hip oil.
Example 11
The stable cleaning composition with repairing and relieving effects comprises the following components: 25g caprylic/capric triglyceride, 6g PEG-20 glyceryl triisostearate, 1.3g boswellia resin extract, 1.3g tripeptide-1, 5g tripeptide-1 copper, 8g camellia oil, 8g jojoba seed oil, 12g jatropha wax and 4g rose hip oil.
Example 12
The stable cleaning composition with repairing and relieving effects comprises the following components: 28g caprylic/capric triglyceride, 9g PEG-20 glyceryl triisostearate, 2g boswellia resin extract, 1.5g tripeptide-1, 6g tripeptide-1 copper, 10g camellia oil, 10g jojoba seed oil, 14g jatropha wax and 6g rose hip oil.
Example 13
The stable cleaning composition with repairing and relieving effects comprises the following components: 20g caprylic/capric triglyceride, 1g PEG-20 glyceryl triisostearate, 0.7g boswellia extract, 0.5g tripeptide-1, 1.5g tripeptide-1 copper, 2g camellia oil, 2g jojoba seed oil, 2g avocado oil, 3g shea butter, 10g jatropha wax, 2g rose hip oil.
Example 14
The stable cleaning composition with repairing and relieving effects comprises the following components: 23g of caprylic/capric triglyceride, 4g of PEG-20 glycerol triisostearate, 1g of boswellia extract, 0.8g of tripeptide-1, 1.8g of tripeptide-1 copper, 5g of camellia oil, 5g of jojoba seed oil, 3g of avocado oil, 4g of shea butter, 11g of jatropha wax and 3g of rosa roxburghii seed oil.
Example 15
The stable cleaning composition with repairing and relieving effects comprises the following components: 25g of caprylic/capric triglyceride, 6g of PEG-20 glyceryl triisostearate, 1g of boswellia extract, 0.9g of tripeptide-1, 2g of tripeptide-1 copper, 6g of camellia oil, 6g of jojoba oil, 4g of avocado oil, 6g of shea butter, 12g of jatropha wax and 4g of rosa roxburghii seed oil.
Example 16
The stable cleaning composition with repairing and relieving effects comprises the following components: 28g of caprylic/capric triglyceride, 9g of PEG-20 glyceryl triisostearate, 2g of boswellia extract, 1g of tripeptide-1, 6g of tripeptide-1 copper, 10g of camellia seed oil, 10g of jojoba seed oil, 6g of avocado oil, 8g of shea butter, 14g of jatropha wax and 6g of rose hip oil.
The preparation method of the compositions of the above examples 1 to 16 comprises the following steps: weighing the components, and stirring and mixing the components uniformly at normal temperature to obtain the product.
The application method of any group of compositions in the above examples 1 to 16 is to add any group of compositions into cosmetics, wherein the composition accounts for 0.5 to 8 percent of the total weight of the cosmetics, and cleaning skin care cosmetics such as makeup removing cream, makeup removing gel, bath cream and the like can be prepared according to the conventional process and auxiliary materials for preparing the cosmetics. The selection of other ingredients in the cosmetic and the preparation process may be carried out according to conventional procedures in the art at the time of manufacture.
To demonstrate the effect of the present invention, comparative examples of the present invention are given below:
comparative example 1
The cleaning composition with stable comparative example and repairing and relieving effects comprises the following components: 23g caprylic/capric triglyceride, 1g mastic resin extract, 1.8g tripeptide-1 copper, 5g jojoba seed oil.
Comparative example 2
The stable cleaning composition with repairing and relieving effects of the comparative example consists of the following components: 4g of PEG-20 glycerol triisostearate, 0.8g of tripeptide-1 and 5g of camellia seed oil.
Comparative example 3
The stable cleaning composition with repairing and relieving effects of the comparative example consists of the following components: 23g caprylic/capric triglyceride, 1g mastic extract, 1.8g tripeptide-1 copper, 5g jojoba oil, 3g avocado oil.
Comparative example 4
The stable cleaning composition with repairing and relieving effects of the comparative example consists of the following components: 4g of PEG-20 glycerol triisostearate, 0.8g of tripeptide-1, 5g of camellia seed oil and 4g of shea butter.
Comparative example 5
The stable cleaning composition with repairing and relieving effects of the comparative example consists of the following components: 23g caprylic/capric triglyceride, 1g mastic extract, 1.8g tripeptide-1 copper, 5g jojoba seed oil, 3g avocado oil, 11g wintercherry wax, 3g rose hip oil.
Comparative example 6
The cleaning composition with stable comparative example and repairing and relieving effects comprises the following components: 4g of PEG-20 glycerol triisostearate, 0.8g of tripeptide-1, 5g of camellia seed oil, 4g of shea butter, 11g of jatropha wax and 3g of rose hip oil.
To better illustrate the advantages of the present invention, the experimental results of the present invention are given below:
1. formulation stability
The stability of the formulation was investigated because the formulation contained various esters such as caprylic/capric triglyceride, PEG-20 glyceryl triisostearate, tripeptide-1, shea butter, etc., vegetable oils and water-soluble ingredients. The specific method comprises the following steps:
(1) Sample treatment: the compositions of examples 1 to 16 and comparative examples 1 to 6, which have just been prepared, are each recorded as A 0 (ii) a The compositions of examples 1 to 16 and comparative examples 1 to 6 were placed in an oven at 50 ℃ in the dark for 30 days, and the data obtained are denoted A 50 . The compositions of examples 1 to 16 and comparative examples 1 to 6 were each prepared as an aqueous solution having a mass concentration of 5%.
(2) Data processing: rate of change =1-A 0 /A 50 The results are shown in Table 1.
Table 1 stability test results
As can be seen from Table 1, the stability of the formulation was divided into four equal times, examples 10 to 16, examples 6 to 9, examples 1 to 5 and comparative examples 1 to 6, from high to low. This is due to the different components of the formulation. All the examples are in a relatively stable state, and example 16 is the highest concentration ratio of all the components, and the system is most stable under the ratio, and the stability rate of the system reaches 95% or more. The comparative examples 5 and 6, which contain the jatropha wax component, clearly show higher stability than the other comparative examples, and also illustrate the stability. Overall, however, all examples had higher stability than all comparative examples, sufficient to demonstrate formulation stability.
2. Testing of repair efficacy
The effect of the cosmetic composition was tested by the epidermal water loss test method with reference to T/GDCA 009-2022.
(1) Test samples: the compositions of examples 1 to 16 and comparative examples 1 to 6 were prepared as 5% aqueous solutions, respectively. Water was also used as a control.
(2) Subject selection
The selection standard is that the age is between 18 and 60 years, healthy male or female; those with positive lactic acid stinging; one of the symptoms of impaired skin barrier function such as dryness, desquamation, and redness of the skin is perceived; understanding the test course, voluntarily taking part in the trial and signing an informed consent form; the product can be used in required amount.
Exclusion criteria were pregnant or lactating women, or those who had a pregnancy plan recently; patients with psoriasis, eczema, atopic dermatitis, etc.; at present or within about one month, the patients are orally taken or externally applied with anti-inflammatory drugs such as corticosteroid hormone; other clinical trial participants are present or nearly one month old; the users do not participate voluntarily and cannot finish the required content on time; other clinical assessments considered unsuitable for participants;
withdrawal criteria are subjects who are considered inappropriate for continuing the study, e.g., by presenting an adverse event during the study or violating the study protocol; in other cases, the clinical study was withdrawn and the reason for withdrawal is indicated.
And (4) safety evaluation: all adverse skin reactions such as redness, stinging, itching, burning etc. that occurred during the study should be recorded and reported in time for severe adverse reactions.
The adverse reaction is judged according to the following three-level standard:
mild-easily tolerated, causes little discomfort, and does not affect normal life.
Moderate-enough to affect normal life.
Severe-hampering normal life.
Adverse reactions relationship to study:
irrelevant-clearly related to other factors; not possible-most likely related to other factors; possibly-after use, but also possibly due to other factors; it is possible-to occur after use, but not explained by other factors; probably-it occurs after use but cannot be explained by other factors and occurs again after use.
Subject: 2 patients with addict, 2 patients with abscission, 30 effective cases, 0 male and 32 female; minimum age: 18 years old, maximum age: age 57; the mean age was 33.09 years.
(3) Measurement procedure
At the first visit, subjects were instructed to perform the trial and signed written informed consent. Subjects were asked a series of questions about disease history, health status, etc., based on inclusion and exclusion criteria, etc., and compliance assessments were made and recorded.
Before the test is started, a face cleaning product without any efficacy is provided by a test center to clean the tested part of the testee; clean skin was tested after sitting still in a satisfactory room for at least 30 minutes. The factors of the cleaning product, the water temperature and the like should be kept consistent every return visit.
Pre-product skin baseline evaluation and testing, including instrumental testing and standard image capture and data recording, were performed on the enrolled qualified subjects. The same test was performed again on day 7 and day 14 after the product was used.
(4) The result of the calculation
Descriptive statistics: descriptive statistics are performed on the measured values of each test area, including quantity, mean, standard deviation, minimum, median, maximum.
And (3) differential analysis: the change rates of the TEWL average values on the sample application side and the control side were calculated, respectively, and then the difference between the sample application area and the control area at different measurement time points was statistically analyzed using the change rates. If the test data is normal distribution, performing statistical analysis by adopting a t test method; if the test data is in a non-normal distribution, a rank sum test method is adopted for statistical analysis. The statistical methods all adopt a two-tail test, and the test level is alpha =0.05.
(5) Determination of results
Positive results: compared with the control side, the change rate of the TEWL value of the sample smearing side is remarkably different, P is less than 0.05, and the tested sample has a promotion effect on the recovery of the transepidermal water loss of the skin with the damaged barrier.
Negative results: compared with the control side, the change rate of the TEWL value of the sample application side has no significant difference P which is more than or equal to 0.05, and the change rate indicates that the tested sample has no promotion effect on the recovery of the transepidermal water loss of the skin with damaged barrier.
TABLE 2 TEWL values of the test samples at different times
Statistical analysis of the experimental results in table 2 shows that the comparative examples and the examples have repairing effects to different degrees, but the change rate of the TEWL value of the water loss through the epidermis of all experimental groups is far higher than that of all experimental groups. Example 16 the transepidermal water loss value decreased by 11% after 7 days of use compared to before the sample, with a very significant difference, indicating that the composition had a repairing effect after 7 days of use. The proportion of the experimental group has a certain reduction rate, but the reduction degree of the experimental group has no significant difference. The control group data also shows almost no repair efficacy, and all the examples in the experimental group have better repair efficacy than the comparative examples, which proves that the repair efficacy is greatly enhanced by the synergistic cooperation of various substances in the composition.
3. Test for soothing efficacy
The method is carried out according to a clinical evaluation standard method of T/CNMIA 0015-2020 allergy-relieving type functional skin care products.
1. Lactic acid sting test
(1) Test samples: the test samples prepared by adding the compositions of examples 1 to 16 and comparative examples 1 to 6 to a common emulsion external base, wherein the stable cleansing composition having the repairing and soothing effects accounts for 5% of the total mass of the emulsion.
(2) The test method comprises the following steps: screening of lactate stinging sensitive muscles: a10% lactic acid solution (50. Mu.L) was dropped on a filter paper having a diameter of 8mm, and placed in the nasolabial folds at both sides of the subject, and the discomfort levels of itching, tingling, and burning sensation at the test site were evaluated by the subject at 30S, 2.5min, and 5min, respectively. Scoring was done on a 4 point scale (0 points no sensation, 1 points mild, 2 points moderate, 3 points severe). The patients with positive lactic acid stabbing pain are classified as if the sum of stabbing pain scores of 2.5min and 5min is more than or equal to 3. The subjects were divided on average into 22 groups (5 persons per group) based on the lactic acid sting screening results, and each group was smeared with a different test sample. The test product was used 1 time each day, morning and evening during the trial run. Taking the lactic acid sting screening score as a basic value, performing the lactic acid sting test again 28 days after the product is used, and performing statistical analysis on the lactic acid sting score before and after the product is used by using SPSS, wherein P <0.05 is a difference and has statistical significance.
TABLE 3 lactic acid sting scores for test samples at different times
As can be seen from the experimental results in table 3, examples 1 to 16 achieved the expected effect, and the stimulation of lactic acid to the skin was reduced, and after Wilcoxon paired rank sum test, the test level α =0.05, p <0.001 was obtained, which indicates that the lactic acid prick score of the subject who continuously used the test samples of examples 1 to 16 for 28 days was significantly different from the base value, and the prick degree was greatly reduced; while comparative examples 1 to 6 are improved compared with those before use, the expected effect is not achieved, the effect is only half of that of the examples, and the fact that the comparative examples may still have sensitivity in a small proportion is shown.
2. Hyaluronidase inhibition assay
Hyaluronidase is a hydrolase for degrading hyaluronic acid, is a main component of extracellular matrix of connective tissue of an organism and is related to most allergic reactions, so that the hyaluronidase in vitro inhibition experiment can react the effects of relieving, resisting allergy, resisting inflammation and the like of a product on skin to a certain extent; hyaluronic acid is a high-order polysaccharide consisting of D-glucuronic acid and N-acetylglucosamine, and is capable of undergoing a color reaction according to the Elson-morgan reaction. The inhibition rate of hyaluronidase in the sample can be determined by this reaction; the greater the inhibition rate, the better the soothing, anti-allergy or sensitivity inhibition effect.
(1) Test samples: the test samples were samples of examples 1 to 16 and comparative examples 1 to 6, and the concentrations were 0.5%, 4%, and 8%, respectively.
(2) The test method comprises the following steps: the test was performed according to the ELSON-MORGAN modified method.
TABLE 4 inhibition of hyaluronidase in samples at different concentrations (unit:%)
As can be seen from the experimental results in Table 4, the hyaluronidase inhibition results of examples 1-16 are significantly higher than those of comparative examples 1-6, indicating that the soothing, anti-allergy or sensitivity inhibition effects of examples 1-16 are better than those of comparative examples 1-6. Although the groups of comparative examples 1 to 6 also have a certain soothing and anti-allergy effect, the soothing effect is not obvious and is far from the examples, and the highest inhibition rate of the comparative example is 9.48% at a concentration of 8%, while the example is 75.17%, which is almost close to 8 times different. The synergistic effect of the components and the content of the components is obvious and obvious.
3. Visia image analysis method
(1) Test samples: the test samples prepared by adding the compositions of examples 1 to 16 and comparative examples 1 to 6 to a general emulsion external base, wherein the stable cleansing composition having the repairing and soothing effects accounts for 5% of the total mass of the emulsion.
(2) Subject selection: same lactic acid stabbing pain selected subjects
(3) Measurement procedure
Visia pictures were taken of D0 before using the sample, and Visia pictures were taken of D7 and D14 at 7 and 14 days, respectively. The results of analyzing the Visia facial red region picture with Image-Pro Plus 7.0C to obtain the red region a value are shown in Table 5.
TABLE 5 facial Red zone a values at different times for test samples
Statistical analysis of the experimental results in table 5 shows that the a values of examples 1-16 are significantly reduced and significantly different from those of 0 days in 7 days and 14 days, and P is less than 0.001. The compositions of examples 1 to 16 are described to have a promoting effect on the recovery of facial inflammation. The recovery effect of comparative examples 1 to 6 on inflammation is not obvious, the recovery effect of examples 1 to 16 on facial inflammation is obviously better than that of comparative examples 1 to 6, the red zone a value is reduced by 13% after the sample is used for 7 days, compared with the value before the sample is used, the sample has a very significant difference, the sample has an obvious effect of relieving facial redness after the sample is used for 7 days, the sample has been reduced to 12.85 on the 14 th day, and the reduction rate reaches 34%. The effective relieving capacity of the Chinese medicinal composition is proved, and the importance and the necessity of the synergistic effect of the formula in solving the problem of skin inflammation are further proved.
In conclusion, the caprylic/capric triglyceride, the PEG-20 glyceryl triisostearate, the boswellia resin extract, the tripeptide-1 copper, the camellia oil, the jojoba oil, the avocado oil, the shea butter, the jatropha wax and the rosa roxburghii seed oil are matched and act synergistically, and the results of a combination stability test, a repair efficacy test and a relieving efficacy test show that in the stability test, although the examples and the comparative examples are stable, the stability of the examples is superior to that of the comparative examples; in the test of repairing efficacy and relieving efficacy, the effect of the embodiment is obviously better than that of the comparative example, the comparative example may have sensitivity in a smaller proportion, and the effect of the embodiment is enhanced by about 8-10 times compared with that of the comparative example, which shows that the effect of the composition in repairing and relieving aspects of the invention is very obvious.
Claims (6)
1. A stable cleaning composition with repairing and relieving effects is characterized by comprising the following components in parts by weight: 10 to 30 parts of caprylic/capric triglyceride, 1 to 10 parts of PEG-20 glycerol triisostearate, 1 to 8 parts of mastic extract, 1 to 7 parts of tripeptide-1 copper, 1 to 10 parts of camellia seed oil and 1 to 10 parts of jojoba seed oil.
2. A stable, repairing and soothing cleansing composition according to claim 1 further comprising from 1 to 10 parts avocado oil and from 8 to 15 parts shea butter.
3. The stable and repairing and soothing cleaning composition as claimed in claim 2, further comprising 4-16 parts of a fruit wax of Lacca sinica exsiccata and 1-10 parts of rose hip oil of Russian rose.
4. The stable repairing and relaxing cleaning composition according to claim 1, comprising the following components in parts by weight: 15-25 parts of caprylic acid/capric acid triglyceride, 2-8 parts of PEG-20 glycerol triisostearate, 2-7 parts of mastic extract, 2-6 parts of tripeptide-1 copper, 2-8 parts of camellia oil and 2-8 parts of jojoba oil.
5. The stable repairing and soothing cleansing composition as claimed in claim 2, wherein said composition comprises the following components in parts by weight: 16-22 parts of caprylic/capric triglyceride, 3-7 parts of PEG-20 glycerol triisostearate, 3-6 parts of mastic extract, 3-6 parts of tripeptide-1 copper, 3-7 parts of camellia seed oil, 3-7 parts of jojoba seed oil, 2-8 parts of avocado oil and 9-13 parts of shea butter.
6. A stable, repairing and soothing cleansing composition according to claim 3 comprising the following components in parts by weight: 16-22 parts of caprylic/capric triglyceride, 3-7 parts of PEG-20 glycerol triisostearate, 3-6 parts of mastic extract, 3-6 parts of tripeptide-1 copper, 3-7 parts of camellia seed oil, 3-7 parts of jojoba seed oil, 2-8 parts of avocado oil, 9-13 parts of shea butter, 5-15 parts of jatropha wax and 2-8 parts of rose hip oil.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116035955A (en) * | 2022-12-28 | 2023-05-02 | 寒霜籽(上海)生物科技有限公司 | Quick-absorption skin-care hair-care dual-purpose oil based on camellia seed oil |
| CN117618283A (en) * | 2023-12-11 | 2024-03-01 | 梅晔生物医药股份有限公司 | Oil-control anti-acne facial cleanser composition, application thereof and gel |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
-
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
Non-Patent Citations (2)
| Title |
|---|
| HEBA A. GAD等: "Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity", 《POLYMERS (BASEL)》, vol. 13, no. 11, pages 1711 * |
| 陕西慧康生物科技有限责任公司: "汝新美肌蓝铜胜肽修护卸妆膏", 《国产普通化妆品备案信息平台，HTTPS://HZPBA.NMPA.GOV.CN/GCCX/》》, pages 1 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116035955A (en) * | 2022-12-28 | 2023-05-02 | 寒霜籽(上海)生物科技有限公司 | Quick-absorption skin-care hair-care dual-purpose oil based on camellia seed oil |
| CN117618283A (en) * | 2023-12-11 | 2024-03-01 | 梅晔生物医药股份有限公司 | Oil-control anti-acne facial cleanser composition, application thereof and gel |
| CN117618283B (en) * | 2023-12-11 | 2024-06-14 | 梅晔生物医药股份有限公司 | Oil-control anti-acne facial cleanser composition, application thereof and gel |
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