CN117100699A - Nose washing agent and preparation method thereof - Google Patents
Nose washing agent and preparation method thereof Download PDFInfo
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- CN117100699A CN117100699A CN202311304256.7A CN202311304256A CN117100699A CN 117100699 A CN117100699 A CN 117100699A CN 202311304256 A CN202311304256 A CN 202311304256A CN 117100699 A CN117100699 A CN 117100699A
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- Prior art keywords
- zein
- water
- sodium alginate
- nasal
- solution
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- 238000005406 washing Methods 0.000 title abstract description 18
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000000661 sodium alginate Substances 0.000 claims abstract description 41
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000341 volatile oil Substances 0.000 claims abstract description 36
- 235000002639 sodium chloride Nutrition 0.000 claims abstract description 33
- 239000000839 emulsion Substances 0.000 claims abstract description 31
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 28
- 239000011780 sodium chloride Substances 0.000 claims abstract description 26
- 239000006185 dispersion Substances 0.000 claims abstract description 24
- 235000018718 Verbena officinalis Nutrition 0.000 claims abstract description 23
- 229920002494 Zein Polymers 0.000 claims abstract description 23
- 239000005019 zein Substances 0.000 claims abstract description 23
- 229940093612 zein Drugs 0.000 claims abstract description 23
- 239000002131 composite material Substances 0.000 claims abstract description 21
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
- 239000006210 lotion Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 2
- 241000424698 Verbena lasiostachys Species 0.000 claims 2
- 210000003928 nasal cavity Anatomy 0.000 abstract description 28
- 240000001519 Verbena officinalis Species 0.000 abstract description 27
- 239000003795 chemical substances by application Substances 0.000 abstract description 16
- 210000001331 nose Anatomy 0.000 abstract description 16
- 239000007921 spray Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 11
- 239000003921 oil Substances 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 208000006673 asthma Diseases 0.000 abstract description 7
- 206010011224 Cough Diseases 0.000 abstract description 6
- 235000007212 Verbena X moechina Moldenke Nutrition 0.000 abstract description 6
- 235000001594 Verbena polystachya Kunth Nutrition 0.000 abstract description 6
- 235000007200 Verbena x perriana Moldenke Nutrition 0.000 abstract description 6
- 235000002270 Verbena x stuprosa Moldenke Nutrition 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 5
- 230000004054 inflammatory process Effects 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 3
- 238000009826 distribution Methods 0.000 abstract description 3
- 208000026435 phlegm Diseases 0.000 abstract description 3
- 230000002829 reductive effect Effects 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 26
- 238000012360 testing method Methods 0.000 description 13
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 230000003020 moisturizing effect Effects 0.000 description 8
- 210000002850 nasal mucosa Anatomy 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
- 239000012267 brine Substances 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010028748 Nasal obstruction Diseases 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical class CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical class C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 229930008380 camphor Chemical class 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000003906 humectant Chemical class 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000001525 mentha piperita l. herb oil Chemical class 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000007922 nasal spray Substances 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 description 1
- 240000000073 Achillea millefolium Species 0.000 description 1
- 235000007754 Achillea millefolium Nutrition 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 239000011703 D-panthenol Chemical class 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical class OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010052437 Nasal discomfort Diseases 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 239000011246 composite particle Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940045109 genistein Drugs 0.000 description 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
- 235000006539 genistein Nutrition 0.000 description 1
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 1
- 229960002849 glucosamine sulfate Drugs 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Otolaryngology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a nose washing agent and a preparation method thereof, which relate to the technical field of nose washing agents and comprise the following components: sea salt, zein, sodium alginate, vervain essential oil, citric acid and water. Compared with the prior art, the zein-sodium alginate composite dispersion emulsion capable of being adsorbed at the interface between the water phase and the oil phase is obtained by wrapping and compositing zein and sodium alginate negative charges and attracting positive charges, the size distribution of the emulsion is narrowed, the hydrophobicity is reduced, and the antibacterial property, the stability and the dispersibility of the emulsion are improved; the addition of the verbena essential oil can help to clear bacteria in nasal cavities and weaken inflammatory reaction, and also has the effects of relieving asthma, reducing phlegm, soothing cough caused by asthma and the like. The nasal wash is clear and transparent solution, and is suitable for spray bottles and matched with the spray bottles.
Description
Technical Field
The invention relates to the technical field of nasal preparations, in particular to a nasal lotion and a preparation method thereof.
Background
Nose washing agents are mainly applied to respiratory tract health care and treatment, traditional nose washing agents mainly comprise saline solution or physiological saline solution, and a plurality of nose washing agents which simulate natural physiological environments of human bodies and contain medicinal components, such as antibacterial agents, antiallergic agents, anti-inflammatory agents and the like, are also appeared on the market. These pharmaceutical ingredients may provide more therapeutic effects, providing more accurate therapeutic effects for specific nasal problems. The nasal wash needs to have mild properties so as not to cause irritation or adverse reaction to nasal mucosa. The nasal wash has the main functions of reducing nasal discomfort by washing dirt, allergen, germs, excessive mucus and the like in the nasal cavity and improving the wettability and smoothness of the nasal cavity. The nasal wash has positive effects on relieving symptoms of nasal problems such as rhinitis, nasal obstruction, cold and the like, and is also commonly used for daily nasal cavity cleaning, nasal cavity moisturizing in dry environment, nasal cavity health maintenance and the like.
By improving the composition, formulation and method of use of nasal washes, the functionality and safety of nasal washes can be continually improved. The polymer such as hydroxypropyl methyl cellulose or hydroxypropyl cellulose is added, so that a protective film can be formed on the surface of nasal mucosa, the effect of the nasal wash is prolonged, and the wetting and moisturizing performances are improved; natural herbal extracts such as aloe, yarrow or witch hazel are added to have anti-inflammatory and nasal cavity relieving effects, and can relieve nasal cavity discomfort and inflammatory reaction; the boric acid has antibacterial and antifungal properties, and can help to remove bacteria and fungi in nasal cavity, so as to improve the cleaning performance of the nasal wash liquid; the golden chrysanthemum extract has the anti-inflammatory and antiallergic properties, can relieve inflammatory reaction and anaphylaxis symptoms of nasal cavity, and can improve the effects of relieving and moisturizing; the glucosamine sulfate is a natural polysaccharide substance, has the functions of moisturizing and repairing nasal mucosa, can increase the moisturizing performance of nasal wash liquid, and promotes the health of nasal mucosa.
CN101259093a discloses a nasal cavity cleaning care solution, which comprises the following raw materials in percentage by weight: 0.001-0.05% of genistein; sorbate 0.01-0.2%; sodium chloride 0.7-1%; dimethyl sulfone 0.01-5%; glycerol or hyaluronic acid 1-5%; essential oil 0.001-0.5%; the solvent is water. The nasal cavity cleaning care solution can clean nasal cavity dirt, inhibit growth of nasal cavity fungus, has a preventive effect on nasopharyngeal carcinoma, and has no toxic or side effect on human bodies and nasal cavities.
CN103096908A discloses a nasal spray comprising the following components: menthol, peppermint oil, camphor, dexpanthenol, humectants, polymers, cellulose derivatives, the invention has been found to have a cooling effect on nasal mucosa with menthol, peppermint oil and optionally camphor, combined with humectants to provide relief to nasal mucosa and improved efficacy compared to nasal sprays containing sea salts and/or ordinary salts. In one embodiment, essential oils, preferably thyme oil, eucalyptus oil and/or sage oil, are added to the aqueous solution until its maximum solubility.
The above-mentioned patent documents report that the nasal wash containing essential oil is not paid attention to whether the essential oil is coagulated and demulsified in the aqueous phase or not, and the dispersibility affects the efficacy, and the dispersibility of the oily substance in water is particularly important because of the small amount of the essential oil.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the technical problem to be solved by the invention is the dispersibility and emulsibility problems of each component in the nasal wash with water and oil, and meanwhile, the nasal wash provided by the invention also has the effects of moisturizing, relieving asthma and soothing cough.
In order to achieve the above purpose, the invention provides a nose washing agent and a preparation method thereof.
Specifically, the nose washing agent comprises sea salt, zein, sodium alginate, verbena essential oil, citric acid and water.
The preparation method of the nose washing agent comprises the following steps:
(1) Adding sea salt into water, refluxing and stirring at 90-100deg.C for 10-20 min, and cooling to room temperature to obtain salt water;
(2) Adding zein into ethanol-water solution, stirring at room temperature for 10-20 min to obtain solution A, adding sodium alginate into water, stirring at room temperature for 10-20 min to obtain solution B, slowly adding solution A into solution B, stirring at 50-60deg.C for 10-30 min, heating to 75-85deg.C, concentrating for 1-3 hr, and removing ethanol to obtain zein-sodium alginate composite dispersion emulsion;
(3) Dripping herba Verbenae essential oil into zein-sodium alginate composite dispersion emulsion, treating for 1-2min at 12000-14000rpm by a super-high speed homogenizer, adding into saline, adding citric acid to adjust pH to subacidity, and stirring at room temperature for 10-30 min to obtain colorless transparent liquid.
The components in the step (1) are as follows in parts by weight: 0.3-0.5 part of sea salt and 40-50 parts of water.
The ethanol-water solution in the step (2) is 80-90wt.% ethanol-water solution.
The components in the step (2) are as follows in parts by weight: 0.6-0.8 part of zein, 6-8 parts of ethanol-water solution, 0.3-0.4 part of sodium alginate and 3-4 parts of water.
The components in the step (3) are as follows in parts by weight: 0.4-1 part of zein-sodium alginate composite dispersion emulsion, 0.05-0.2 part of vervain essential oil and 0.1-1 part of citric acid.
The content of the effective components of the vervain essential oil in the step (3) is 95-99 wt%.
And (3) adjusting the pH value to be slightly acidic in the step (3) to be 4.8-5.5.
Preferably, the nasal wash is a clear transparent solution.
Preferably, the nasal wash is suitable for use with a spray bottle, in combination with a spray bottle.
The nasal wash of the invention takes water as a basic component and acts to dilute other components, help soften mucus in nasal cavity and alleviate nasal obstruction; adding sea salt into water to obtain salt water, which can provide mild cleaning effect, help to remove dirt and allergen in nasal cavity, and maintain physiological salt balance in nasal cavity; the pH value of the citric acid is regulated to be weak acid, so that a better antibacterial environment is produced, and the mucous membrane in the nasal cavity is not stimulated; sodium alginate is a natural polysaccharide extracted from seaweed, can form a protective gel coating under acidic conditions, can also play a role in regulating acid-base balance, and reduces adverse reactions of nasal cavity mucous membrane and human health caused by nasal washes.
The vervain essential oil contains various natural antibacterial components, has antibacterial and anti-inflammatory properties, and can help to clear bacteria in nasal cavity and reduce inflammatory reaction; the herba Verbenae extract can relieve cough symptoms caused by common cold, allergy or other respiratory tract problems, and has effects of relieving asthma, eliminating phlegm, and relieving cough caused by asthma.
According to the invention, zein and sodium alginate negative charge are wrapped and compounded, and zein-sodium alginate composite dispersion emulsion which can be adsorbed at the interface between a water phase and an oil phase is obtained through positive and negative charge attraction, so that the size distribution of the emulsion is narrowed, meanwhile, the hydrophobicity is reduced, the antibacterial property and stability of the emulsion are improved, the emulsification process is kept uniformly dispersed when vervain essential oil is added, and the phenomenon of instability such as flocculation or demulsification affecting the shape or clarity of the nasal wash is avoided.
The zein composite particles added in the invention have the following functions:
1. emulsion stability: zein has good interfacial adsorption and emulsifying properties, combines the vervain essential oil with saline water to form a stable emulsion system, and helps to maintain the uniformity and stability of the mixture.
2. Uniform dispersion: the zein can promote the uniform dispersion of each component in the liquid, and a stable interface film is formed in the nasal wash emulsion coexisting with the water-oil system, so that the stability and the dispersibility of the emulsion are improved, and the functions of each component in the nasal wash are better exerted.
3. Water retention and oil retention: the zein has good water retention performance and oil retention performance, can absorb water and prevent evaporation of the water, forms a protective film with good ductility in the nasal cavity after using the nose washing agent, and simultaneously improves the moisturizing effect and keeps the water-oil balance in the nasal cavity.
The invention has the beneficial effects that:
1. the nasal wash of the invention adds sea salt into water to obtain saline, which can provide mild cleaning function, maintain physiological saline balance in nasal cavity, help soften mucus in nasal cavity and alleviate nasal obstruction.
2. Compared with the prior art, the vervain essential oil added in the invention contains various natural antibacterial components, has antibacterial and anti-inflammatory properties, and can help to clear bacteria in nasal cavity and weaken inflammatory reaction; the herba Verbenae extract can relieve cough symptoms caused by common cold, allergy or other respiratory tract problems, and has effects of relieving asthma, eliminating phlegm, and relieving cough caused by asthma.
3. Compared with the prior art, the zein-sodium alginate composite dispersion emulsion capable of being adsorbed at the interface between the water phase and the oil phase is obtained by wrapping and compositing zein and sodium alginate negative charges and attracting positive charges, the size distribution of the emulsion is narrowed, the hydrophobicity is reduced, and the antibacterial property, the stability and the dispersibility of the emulsion are improved; the sodium alginate can form a protective gel coating under the acidic condition, and can also play a role in regulating acid-base balance and reducing nasal mucosa irritation; when the vervain essential oil is added, the emulsification process is kept uniformly dispersed, the phenomenon of instability such as flocculation or demulsification is avoided, the form or clarity of the nasal wash is influenced, and the functions of all components in the nasal wash are better exerted. The zein has good water retention performance and oil retention performance, can absorb water and prevent evaporation of the water, forms a protective film with good ductility in the nasal cavity after using the nose washing agent, and simultaneously improves the moisturizing effect and keeps the water-oil balance in the nasal cavity.
Detailed Description
The following description of the present invention will be made clearly and fully, and it is apparent that the embodiments described are some, but not all, of the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention is further illustrated with reference to specific embodiments.
The parameters of the specific chemicals used in the examples were derived as follows:
vervain essential oil: the active ingredient content was 99wt.%, available from red star natural medicinal flavor oil factory, jishui county, catalogue 436.
Zein: pharmaceutical grade, available from wuhan pu world biotechnology limited under the accession number 20211206.
Example 1: a preparation method of nasal lotion comprises the following steps:
(1) Adding 4g of sea salt into 450g of deionized water, refluxing and stirring for 15 minutes at 95 ℃, and cooling to room temperature to obtain brine for later use;
(2) Adding 6g of zein and 1g of vervain essential oil into saline in sequence, adding 4.6g of citric acid to adjust the pH value to 5.4, and stirring at room temperature for 20 minutes to obtain colorless transparent liquid, thus obtaining the nose washing agent.
Example 2: a preparation method of nasal lotion comprises the following steps:
(1) Adding 4g of sea salt into 450g of deionized water, refluxing and stirring for 15 minutes at 95 ℃, and cooling to room temperature to obtain brine for later use;
(3) Adding 6g of sodium alginate and 1g of verbena essential oil into saline in sequence, adding 4.6g of citric acid to adjust the pH value to 5.4, and stirring at room temperature for 20 minutes to obtain colorless transparent liquid, thus obtaining the nose washing agent.
Example 3: a preparation method of nasal lotion comprises the following steps:
(1) Adding 4g of sea salt into 450g of deionized water, refluxing and stirring for 15 minutes at 95 ℃, and cooling to room temperature to obtain brine for later use;
(2) Adding 4g of zein, 2g of sodium alginate and 1g of vervain essential oil into saline in sequence, adding 4.6g of citric acid to adjust the pH value to 5.4, and stirring at room temperature for 20 minutes to obtain colorless transparent liquid, thus obtaining the nose washing agent.
Example 4: a preparation method of nasal lotion comprises the following steps:
(1) Adding 4g of sea salt into 450g of deionized water, refluxing and stirring for 15 minutes at 95 ℃, and cooling to room temperature to obtain brine for later use;
(2) Adding 8g of zein into 80g of 80wt.% ethanol-deionized water solution, stirring at room temperature for 10 minutes to obtain solution A, adding 4g of sodium alginate into 40g of deionized water, stirring at room temperature for 10 minutes to obtain solution B, slowly adding the solution A into the solution B, stirring at 55 ℃ for 15 minutes, heating to 85 ℃ and concentrating for 2 hours to remove ethanol to obtain zein-sodium alginate composite dispersion emulsion for later use;
(3) Adding 6g of zein-sodium alginate composite dispersion emulsion and 1g of vervain essential oil into saline in sequence, adding 4.6g of citric acid to adjust the pH value to 5.4, and stirring at room temperature for 20 minutes to obtain colorless transparent liquid, thus obtaining the nose washing agent.
Example 5: a preparation method of nasal lotion comprises the following steps:
(1) Adding 4g of sea salt into 450g of deionized water, refluxing and stirring for 15 minutes at 95 ℃, and cooling to room temperature to obtain brine for later use;
(2) Adding 8g of zein into 80g of 80wt.% ethanol-deionized water solution, stirring at room temperature for 10 minutes to obtain solution A, adding 4g of sodium alginate into 40g of deionized water, stirring at room temperature for 10 minutes to obtain solution B, slowly adding the solution A into the solution B, stirring at 55 ℃ for 15 minutes, heating to 85 ℃ and concentrating for 2 hours to remove ethanol to obtain zein-sodium alginate composite dispersion emulsion for later use;
(3) Dripping 1g of vervain essential oil into 6g of zein-sodium alginate composite dispersion emulsion, processing for 2min at 13000rpm by a super-high speed homogenizer, adding into salt water, adding 4.6g of citric acid to adjust the pH value to 5.4, and stirring at room temperature for 20 min to obtain colorless transparent liquid, thus obtaining the nose washing agent.
Test example 1
Delivered dose uniformity test
The nasal washes prepared in examples 1-5 were tested for delivery dose uniformity according to the chinese pharmacopoeia 2020 edition-general rule 0106 nasal formulation. The test results are shown in Table 1, and the test steps are as follows:
the nasal washes prepared in examples 1-5 were filled into 50mL spray bottles to obtain test samples, 10 bottles for each group. Shaking the sample to be tested for 5 seconds, and discarding 1 spray; after waiting at least 5 seconds, shaking the sample to be tested for 5 seconds, discarding 1 spray, and repeating the operation until discarding 5 sprays; after waiting for 2 seconds, the sample to be tested is placed in the normal position, the pressing device sprays the sample to be tested into the collecting device in a vertical spraying mode 1, the liquid medicine in the solvent collecting device is regulated under each variety item, the medicine amount in the collecting liquid is measured by the analysis method regulated under each variety item, and 10 bottles of the sample to be tested in each group are repeatedly measured.
Result determination conditions:
(1) Of the 10 measurements, if at least 9 measurements are between 75-125% of the average and all measurements are between 65-135% of the average.
(2) If 2-3 measured values exceed 75-125% in 10 measured results, 20 bottles of test samples should be additionally taken for measurement, and if 30 measured values exceed 75-125% in no more than 3 measured values, the total measured values are 65-135%.
One of the above conditions is satisfied, and it can be determined that the rule is satisfied.
Table 1 delivered dose uniformity test results
| Examples | Average measured value | Determination result |
| Example 1 | 78.5% | Qualified product |
| Example 2 | 95.0% | Qualified product |
| Example 3 | 86.4% | Qualified product |
| Example 4 | 104.8% | Qualified product |
| Example 5 | 115.8% | Qualified product |
Comparison of the delivered dose uniformity test of test example 1 shows that example 1 alone with the addition of verbena essential oil and zein, despite dilution with a large amount of water, affected dose delivery uniformity upon use due to non-aqueous dispersion; example 2 adding vervain essential oil and sodium alginate soluble in water, dose delivery uniformity was acceptable, but did not aid in the dispersibility of the vervain essential oil; example 3 addition of vervain essential oil, zein, sodium alginate alone, delivery uniformity was lower than that of sodium alginate with only water; the zein-sodium alginate composite dispersion emulsion is further prepared in examples 4 and 5, except that the verbena essential oil is directly added into the saline or the zein-sodium alginate composite dispersion emulsion is added into the saline, and compared with example 5, the zein-sodium alginate composite dispersion emulsion has good dispersibility and more uniform delivery dosage, so that the nasal wash has better use effect when being added into a spray bottle.
Test example 2
Appearance stability test
The nasal washes prepared in examples 1 to 5 were filled into 50mL spray bottles to obtain samples to be tested, and the samples were placed in a refrigerator and a constant temperature incubator, stored at 15℃and 25℃and 35℃for 24 hours, and subjected to an external stability test to see whether the nasal washes were layered, suspended and emulsified at room temperature, below room temperature and above room temperature, and the appearance of the nasal washes was recorded as non-clear liquid, and the test results were shown in Table 2.
TABLE 2 Low temperature storage and thermal stability test results
| Examples/temperatures | 15℃ | 25℃ | 35℃ |
| Example 1 | Non-clarified liquid | Non-clarified liquid | Non-clarified liquid |
| Example 2 | Non-clarified liquid | Non-clarified liquid | Non-clarified liquid |
| Example 3 | Non-clarified liquid | Non-clarified liquid | Non-clarified liquid |
| Example 4 | Non-clarified liquid | Clarifying solution | Non-clarified liquid |
| Example 5 | Clarifying solution | Clarifying solution | Clarifying solution |
Test example 2 comparison shows that the nasal washes of examples 1 to 5 were stored at 15℃and 25℃and 35℃for 24 hours, and that the appearance stability of example 5 was the best as shown in Table 2 comparison.
As can be seen from the comparison of the appearance stability test of the test example 2, the individual addition of the vervain essential oil and the zein in the example 1, the individual addition of the vervain essential oil and the sodium alginate in the example 2, the individual addition of the vervain essential oil, the zein and the sodium alginate in the example 3, the appearance stability of the examples 1-3 is low, the stability of the vervain essential oil is not helpful, and the vervain essential oil is not in a clear state after being stored for 24 hours at 15 ℃ and 25 ℃ and 35 ℃; the zein-sodium alginate composite dispersion emulsion is further prepared in examples 4 and 5, and is different in that the verbena essential oil is directly added into the saline or the zein-sodium alginate composite dispersion emulsion is added into the saline, and compared with the zein-sodium alginate composite dispersion emulsion, the zein-sodium alginate composite dispersion emulsion in example 5 has good appearance stability, and no appearance states such as layering, suspension, emulsification and the like appear after the zein-sodium alginate composite dispersion emulsion is stored at 15 ℃, 25 ℃ and 35 ℃ for 24 hours, so that the nasal wash has better use effect when being added into a spray bottle.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (7)
1. A method for preparing a nasal wash, comprising the steps of:
(1) Adding sea salt into water, refluxing at 90-100deg.C, stirring, and cooling to room temperature to obtain salt water;
(2) Adding zein into ethanol-water solution, stirring at room temperature to obtain solution A, adding sodium alginate into water, stirring at room temperature to obtain solution B, slowly adding solution A into solution B, stirring, heating and concentrating to obtain zein-sodium alginate composite dispersion emulsion;
(3) Dripping herba Verbenae essential oil into zein-sodium alginate composite dispersion emulsion, processing by a super-high speed homogenizer, adding into saline, adding citric acid to adjust pH value to weak acidity, and stirring at room temperature to obtain colorless transparent liquid to obtain the nasal lotion.
2. A method of preparing a nasal wash according to claim 1, wherein:
the components in the step (1) are as follows in parts by weight: 0.3-0.5 part of sea salt and 40-50 parts of water;
the components in the step (2) are as follows in parts by weight: 0.6-0.8 part of zein, 6-8 parts of ethanol-water solution, 0.3-0.4 part of sodium alginate and 3-4 parts of water;
the components in the step (3) are as follows in parts by weight: 0.4-1 part of zein-sodium alginate composite dispersion emulsion, 0.05-0.2 part of vervain essential oil and 0.1-1 part of citric acid.
3. The method of preparing a nasal wash according to claim 1 or 2, wherein the ethanol-water solution in step (2) is 80 to 90wt.% ethanol-water solution.
4. The method for preparing nasal wash according to claim 1 or 2, wherein the content of the effective components of the vervain essential oil in the step (3) is 95-99 wt%.
5. The method for preparing nasal wash according to claim 1, wherein the ultra-high speed homogenizer in the step (3) has a rotation speed of 12000-14000rpm.
6. The method of preparing nasal wash according to claim 1, wherein the step (3) of adjusting the pH to weak acidity is adjusting the pH to 4.8-5.5.
7. A nasal wash prepared by the method of any one of claims 1-6.
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