CN113967185A - No-clean disinfectant and preparation method thereof - Google Patents
No-clean disinfectant and preparation method thereof Download PDFInfo
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- CN113967185A CN113967185A CN202010708120.2A CN202010708120A CN113967185A CN 113967185 A CN113967185 A CN 113967185A CN 202010708120 A CN202010708120 A CN 202010708120A CN 113967185 A CN113967185 A CN 113967185A
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- disinfectant
- extract
- skin
- clean
- agent
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000003906 humectant Substances 0.000 claims abstract description 12
- 239000000419 plant extract Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 5
- 230000008901 benefit Effects 0.000 claims abstract description 3
- 239000008367 deionised water Substances 0.000 claims abstract description 3
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 3
- 239000000284 extract Substances 0.000 claims description 20
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 5
- 229960003966 nicotinamide Drugs 0.000 claims description 5
- 235000005152 nicotinamide Nutrition 0.000 claims description 5
- 239000011570 nicotinamide Substances 0.000 claims description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 4
- 239000009429 Ginkgo biloba extract Substances 0.000 claims description 4
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- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims description 4
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 4
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- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims description 4
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- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims description 4
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- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 240000001548 Camellia japonica Species 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 3
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- 150000001875 compounds Chemical class 0.000 description 3
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- QAQJMLQRFWZOBN-UHFFFAOYSA-N 2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)C1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-UHFFFAOYSA-N 0.000 description 1
- 241000209507 Camellia Species 0.000 description 1
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- 150000004283 biguanides Chemical class 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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Classifications
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
The invention discloses a no-clean disinfectant and a preparation method thereof, and the no-clean disinfectant comprises the following components in percentage by weight: 60-80% of ethanol, 0.05-0.1% of polyhexamethylene biguanide, 1-5% of humectant, 1-5% of skin care agent, 5-10% of plant extract, 0.5-2% of fat-liquoring agent, 0.01-0.5% of pH regulator, 0.5-2% of stabilizer and the balance of deionized water. The washing-free disinfectant disclosed by the invention has the following advantages: (1) has good bacteriostatic and sterilizing effects; (2) various moisturizing and skin-care ingredients are added, so that the harm of alcohol to hands can be counteracted, a layer of protective film can be formed, and the effects of moisturizing and moistening the skin for a long time are achieved; (3) the invention adds a certain amount of plant extracts, and part of the plant extracts have natural plant fragrance and have the efficacies of synergistic bacteriostasis and skin care, and the components are natural, safe and non-irritating.
Description
Technical Field
The invention relates to the field of disinfectant, in particular to a no-clean disinfectant and a preparation method thereof.
Background
In the process of disease infection, hands are extremely important links and ways for transmitting microorganisms, and the use of the hand disinfectant can control bacteria on the skin within a certain range, so that the hand disinfectant does not form the risk of disease transmission for other people, and the hand sanitizer is extremely important for preventing diseases and guaranteeing the health as a skin cleanser for cleaning hands.
The hand sanitizer in the market is mainly divided into a washing type and a no-washing type, wherein the washing type needs to be washed by water, but has great limitation under the condition of no water, and the no-washing hand sanitizer is popular among consumers because of being convenient to carry, free of washing and capable of cleaning both hands anytime and anywhere. The main disinfection component of the no-clean hand sanitizer is ethanol, the ethanol is volatile and does not remain, the use is safe, the alcohol disinfectant has good killing effect on pathogenic microorganisms, the principle of the alcohol disinfectant is alcohol coagulable protein, so that the microorganisms die, in recent years, the compound alcohol disinfectant is popular, biguanide substances are added into the no-clean hand sanitizer, the compounds can change the permeability of bacterial cell membranes, the sterilization effect and the sterilization speed can be improved by compounding the compounds with the ethanol, and the no-clean hand sanitizer is also suitable for skin disinfection. While the antibacterial agents such as ethanol or biguanides have certain irritation, and the skin of hands is dry and rough after long-term use, so that the natural protective barrier of the skin is damaged. Therefore, a disposable disinfectant product which can meet the requirements of antibiosis and sterilization and has the effects of moisturizing and protecting skin is needed in the market.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a no-clean disinfectant and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the no-clean disinfectant comprises the following components in percentage by weight: 60-80% of ethanol, 0.05-0.1% of polyhexamethylene biguanide, 1-5% of humectant, 1-5% of skin care agent, 5-10% of plant extract, 0.5-2% of fat-liquoring agent, 0.01-0.5% of pH regulator, 0.5-2% of stabilizer and the balance of deionized water.
As a preferred embodiment of the no-clean disinfection solution, the humectant is one or more of glycerol, 1, 3-butanediol, 1, 3-propanediol and amino acid humectant.
As a preferred embodiment of the no-clean disinfection solution of the present invention, the skin care agent is one or more of niacinamide, ascorbyl palmitate, panthenol and jojoba oil.
As a preferred embodiment of the no-clean disinfection solution of the present invention, the plant extract is one or more of rose extract, dried orange peel extract, oat polypeptide extract, camellia extract, aloe extract, peony root bark extract, asiaticoside and ginkgo biloba extract.
As a preferable embodiment of the no-clean disinfection solution, the fatting agent is one or more of fatty glyceride and ethyl cellulose.
As a preferred embodiment of the no-clean disinfectant, the pH regulator is sodium hydroxide or potassium hydroxide or a mixture of the sodium hydroxide and the potassium hydroxide, and the pH value is regulated to 6.0-7.5.
As a preferable embodiment of the no-clean disinfection solution, the stabilizer is disodium ethylene diamine tetraacetate.
The invention also provides a preparation method of the no-clean disinfectant, which comprises the following steps:
a) adding polyhexamethylene biguanide and disodium ethylene diamine tetraacetate into water, and uniformly stirring until the solid is completely dissolved to obtain a first mixture;
b) adding the first mixture obtained in the step a) into ethanol, and uniformly stirring to obtain a second mixture;
c) adding the plant extract, the humectant, the skin care agent and the fatting agent into the second mixture obtained in the step b) in sequence, and mixing uniformly to obtain the no-clean disinfectant.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
(1) in the no-clean disinfectant, the concept of moisturizing and skin care is emphasized in the selection of raw materials. The natural amino acid humectant is added, so that the irritation of the product to the skin can be reduced, the repair of the skin is promoted, and the damage of free radicals is reduced, and meanwhile, the glycerin, the 1, 3-butanediol and the 1, 3-propanediol are added to assist in moisturizing and enhancing the effect; according to the invention, the nicotinamide skin care agent is added, and the nicotinamide has a deep water-locking function, can synergistically moisturize, and can repair damaged stratum corneum lipid barriers and improve skin resistance; the jojoba oil skin care agent is added, so that the skin can be massaged and protected, the water loss is avoided, and the skin is nourished and deeply cared; the ascorbyl palmitate is added to play a role in resisting oxidation of the skin; the panthenol can soften and moisten the skin and effectively improve the rough skin phenomenon; the fat-liquoring agent is added in the invention, so that a layer of protective film can be formed on the surface of the skin, and the moisture of the skin is locked to achieve the effect of moisturizing while the skin is protected from external interference. Alcohol has certain irritation to skin, and can be used for bringing burden to skin of a user, and various moisturizing and skin care ingredients are added into the product, so that the harm of alcohol to hands can be counteracted, and the moisturizing and skin moistening effects can be achieved to a certain degree.
(2) The main disinfection components of the invention are ethanol and biguanide disinfectants, and the ethanol disinfectants can solidify protein, thereby causing the death of microorganisms and having good killing effect on pathogenic microorganisms; the biguanide substances are added into the ethanol, the permeability of bacterial cell membranes can be changed by the biguanide substances, the sterilization effect and the sterilization speed of the biguanide substances can be improved by compounding the biguanide substances with the ethanol, the components can be further synergized and scientifically matched on the basis of fully playing the respective effects, the resultant force is formed, the defects of narrow sterilization spectrum and low sterilization efficiency under the action of a single component are overcome, and the synergistic sterilization effect is achieved.
(3) The washing-free disinfectant adopts various plant extracts, and the peony root bark extract, the tangerine peel extract and the asiaticoside have good antibacterial and bacteriostatic abilities and can synergistically resist bacteria; the rose extract, the oat polypeptide extract, the camellia extract, the aloe extract and the ginkgo leaf extract have the effects of moisturizing, protecting skin, calming and resisting allergy, and are natural and safe moisturizing and skin-protecting components; in addition, the plant extract can also increase the special aromatic smell of the hand-washing-free disinfectant, and the smell is fresh and natural and can be kept fragrant for a long time.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to specific embodiments.
Examples 1 to 7
Table 1 formula of no-clean disinfectant liquid described in examples 1 to 7
| Component (%) | Example 1 | Example 2 | Example 3 | Examples4 | Example 5 | Example 6 | Example 7 |
| Ethanol | 60 | 65 | 70 | 75 | 75 | 80 | 80 |
| Polyhexamethylene biguanide | 0.1 | 0.1 | 0.075 | 0.05 | 0.05 | 0.05 | 0.05 |
| Glycerol | 2 | 0 | 2 | 2 | 1 | 2 | 2 |
| 1, 3-butanediol | 3 | 0 | 1 | 2 | 1 | 1 | 1 |
| 1, 3-propanediol | 0 | 3 | 0 | 1 | 1 | 0 | 0 |
| Amino acid humectant | 0 | 2 | 1 | 0 | 0 | 0 | 0 |
| Nicotinamide | 2 | 0 | 1 | 2 | 2 | 0 | 0 |
| Jojoba oil | 2 | 0 | 2 | 0 | 0 | 2 | 1 |
| Ascorbyl palmitate | 0 | 2 | 1 | 1 | 1 | 2 | 1 |
| Panthenol | 0 | 2 | 0 | 0 | 0 | 1 | 1 |
| Rose extract | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dried orange peel extract | 4 | 4 | 0 | 0 | 0 | 0 | 0 |
| Oat polypeptide extract | 0 | 4 | 0 | 0 | 0 | 3 | 0 |
| Camellia extract | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| Aloe extract | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Peony root bark extract | 0 | 0 | 2 | 2 | 2 | 0 | 0 |
| Asiaticoside | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
| Ginkgo leaf extract | 0 | 0 | 0 | 0 | 3 | 0 | 3 |
| Fatty acid glycerides | 1.5 | 1.5 | 0 | 0.5 | 0 | 0.5 | 0 |
| Ethyl cellulose | 0 | 0 | 0.5 | 0 | 0.5 | 0 | 0.5 |
| Ethylenediaminetetraacetic acid disodium salt | 0.5 | 0.5 | 1 | 1 | 1 | 1 | 1 |
| Sodium hydroxide | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount | Adjusting pH to 6.0- 7.0 required amount |
| Water (W) | Balance of | Balance of | Balance of | Balance of | Balance of | Balance of | Balance of |
The preparation method of the no-clean disinfectant comprises the following steps:
a) adding polyhexamethylene biguanide and disodium ethylene diamine tetraacetate into water, and uniformly stirring until the solid is completely dissolved to obtain a first mixture;
b) adding the first mixture obtained in the step a) into ethanol, and uniformly stirring to obtain a second mixture;
c) adding the plant extract, the humectant, the skin care agent and the fatting agent into the second mixture obtained in the step b) in sequence, and mixing uniformly to obtain the no-clean disinfectant.
1. Sensory index
The sensory indexes of the no-clean disinfection solutions of the examples 1 to 7 are as follows: no layering, no suspended matter or precipitate, no obvious mechanical impurity, no odor and other advantages.
2. Skin irritation test
Sample preparation: the hand sanitizer solutions of examples 1-7 were mixed.
The test method comprises the following steps: selecting 6 healthy rabbits with intact skin, and removing hair on two sides of spinal column of rabbit with depilatory 24h before test, without damaging skin, wherein the hair removing range is about 3cm × 3cm on left and right sides; the following day, the test substance (typically 5 times the concentration of the skin sanitizing application or 0.5ml (g) of the stock solution) is applied to one side of the skin, the other side is applied with a control solution, and after 4 hours of application, the skin is rinsed with water or a suitable non-irritating solvent to remove residue, the application is performed once a day, the results are continuously applied 14d after each application, the results are observed 24 hours after each application, and are scored according to tables 2 and 3.
The average integral per animal per day (irritation index) was calculated according to the following formula, and the skin irritation intensity was judged in table 2.
TABLE 2 Scoring criteria for skin irritation response
TABLE 3 skin irritation Strength grading
Table 4 skin irritation test results
And (3) test results: the integral mean value of the sample for each animal per day in multiple skin irritation tests of rabbits is 0.10, and the sample is classified according to skin irritation strength of disinfection technical specification and is non-irritant.
3. Sterilization test
The test is divided into test groups 1-7, the test groups 1-7 respectively adopt the no-clean disinfectant prepared in the examples 1-7, and staphylococcus aureus (ATCC 6538), escherichia coli (8099) and candida albicans (ATCC 10231) are selected as the test strains to prepare the bacterial suspension for quantitative sterilization experiments. This procedure is carried out according to the method steps of the Disinfection Specification (2002 edition) and is not described in detail here.
TABLE 5 Sterilization Effect kill Rate
| Test group | Staphylococcus aureus | Escherichia coli | Candida albicans |
| Example 1 | 99.1% | 99.1% | 99.2% |
| Example 2 | 99.4% | 99.3% | 99.3% |
| Example 3 | 99.5% | 99.6% | 99.4% |
| Example 4 | 99.6% | 99.6% | 99.7% |
| Example 5 | 99.7% | 99.6% | 99.5% |
| Example 6 | 99.9% | 99.7% | 99.8% |
| Example 7 | 99.9% | 99.6% | 99.7% |
4. Stability test
And (3) accelerated test: the original packaging sample is placed in a constant temperature box at 37-40 ℃ for 3 months, the relative humidity is kept to be more than 75%, the sterilization performance test is carried out, and through the test, the killing log values of the samples in the examples 1-7 to staphylococcus aureus (ATCC 6538), escherichia coli (8099) and candida albicans (ATCC 10231) are all more than 5.
The above-mentioned embodiments only express the embodiments of the present invention, and the description is more specific and detailed, but not understood as the limitation of the patent scope of the present invention, but all the technical solutions obtained by using the equivalent substitution or the equivalent transformation should fall within the protection scope of the present invention.
Claims (8)
1. The no-clean disinfectant and the preparation method thereof are characterized by comprising the following components in percentage by weight: 60-80% of ethanol, 0.05-0.1% of polyhexamethylene biguanide, 1-5% of humectant, 1-5% of skin care agent, 5-10% of plant extract, 0.5-2% of fat-liquoring agent, 0.01-0.5% of pH regulator, 0.5-2% of stabilizer and the balance of deionized water.
2. The leave-in disinfectant of claim 1 wherein said humectant is one or more of glycerin, 1, 3-butylene glycol, 1, 3-propylene glycol, and an amino acid humectant.
3. The leave-on disinfectant of claim 1 wherein said skin benefit agent is one or more of niacinamide, ascorbyl palmitate, panthenol and jojoba oil.
4. The leave-in disinfectant of claim 1 wherein said plant extract is one or more of rose extract, dried orange peel extract, oat polypeptide extract, camellia extract, aloe extract, peony root bark extract, asiaticoside and ginkgo biloba extract.
5. The no-clean disinfectant as set forth in claim 1, wherein said fatliquoring agent is one or more of fatty glyceride and ethyl cellulose.
6. The no-clean disinfectant as claimed in claim 1, wherein said pH regulator is sodium hydroxide or potassium hydroxide or a mixture of sodium hydroxide and potassium hydroxide, and the pH value is adjusted to 6.0-7.5.
7. The leave-in disinfectant of claim 1 wherein said stabilizer is disodium ethylenediaminetetraacetate.
8. A method for preparing the no-clean disinfectant as claimed in any one of claims 1 to 7, which comprises the following steps:
adding polyhexamethylene biguanide and disodium ethylene diamine tetraacetate into water, and uniformly stirring until the solid is completely dissolved to obtain a first mixture;
adding the first mixture obtained in the step a) into ethanol, and uniformly stirring to obtain a second mixture;
adding the plant extract, the humectant, the skin care agent and the fatting agent into the second mixture obtained in the step b) in sequence, and mixing uniformly to obtain the no-clean disinfectant.
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|---|---|---|---|---|
| CN115119849A (en) * | 2022-07-02 | 2022-09-30 | 厦门迈诺泰医疗科技有限公司 | Decontamination disinfectant for appliances and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1964576A1 (en) * | 2007-02-27 | 2008-09-03 | Certmedica International GmbH | Aqueous disinfectant gel preparation |
| CN102265894A (en) * | 2011-06-08 | 2011-12-07 | 江中药业股份有限公司 | Composition for killing microorganisms |
| CN103977155A (en) * | 2014-05-29 | 2014-08-13 | 上海宇昂水性新材料科技股份有限公司 | Cleaning-free compound hand sanitizer and preparation method thereof |
-
2020
- 2020-07-22 CN CN202010708120.2A patent/CN113967185A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1964576A1 (en) * | 2007-02-27 | 2008-09-03 | Certmedica International GmbH | Aqueous disinfectant gel preparation |
| CN102265894A (en) * | 2011-06-08 | 2011-12-07 | 江中药业股份有限公司 | Composition for killing microorganisms |
| CN103977155A (en) * | 2014-05-29 | 2014-08-13 | 上海宇昂水性新材料科技股份有限公司 | Cleaning-free compound hand sanitizer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 徐平如;赖桂兰;周明灿;: "护肤型消毒杀菌洗手液的研制" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115119849A (en) * | 2022-07-02 | 2022-09-30 | 厦门迈诺泰医疗科技有限公司 | Decontamination disinfectant for appliances and preparation method thereof |
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