CN103599898B - Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device - Google Patents
Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device Download PDFInfo
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- CN103599898B CN103599898B CN201310522625.XA CN201310522625A CN103599898B CN 103599898 B CN103599898 B CN 103599898B CN 201310522625 A CN201310522625 A CN 201310522625A CN 103599898 B CN103599898 B CN 103599898B
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- reaction cup
- magnetic bead
- cleaning
- rotating disc
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- 238000004140 cleaning Methods 0.000 title claims abstract description 56
- 239000011324 bead Substances 0.000 title claims abstract description 50
- 238000004458 analytical method Methods 0.000 title claims abstract description 17
- 238000003018 immunoassay Methods 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 81
- 239000007788 liquid Substances 0.000 claims abstract description 35
- 230000009471 action Effects 0.000 claims abstract description 22
- 239000012530 fluid Substances 0.000 claims abstract description 15
- 239000002699 waste material Substances 0.000 claims abstract description 13
- 239000003463 adsorbent Substances 0.000 claims abstract description 11
- 238000002347 injection Methods 0.000 claims abstract description 5
- 239000007924 injection Substances 0.000 claims abstract description 5
- 238000000429 assembly Methods 0.000 claims abstract description 4
- 230000000712 assembly Effects 0.000 claims abstract description 4
- 238000007865 diluting Methods 0.000 claims abstract description 4
- 230000007246 mechanism Effects 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 5
- 229910052701 rubidium Inorganic materials 0.000 claims description 4
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical group [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/08—Cleaning involving contact with liquid the liquid having chemical or dissolving effect
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/044—Cleaning involving contact with liquid using agitated containers in which the liquid and articles or material are placed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/14—Removing waste, e.g. labels, from cleaning liquid
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, comprise reaction cup rotating disc, lifting punch block, magnetic bead adsorbent equipment and evenly mixing device, described lifting punch block drives linearly slide rail vertically to move up and down by spindle motor, lifting punch block is provided with eight cleaning needle assemblies, wherein four pins are for telling liquid pin, for injecting cleaning fluid in reaction cup, four pins are aspirating needle, for drawing the waste liquid in reaction cup; Described eight groups of cleaning needles carry out the action of injection cleaning fluid to reaction cup successively and draw waste liquid action, realize once diluting the magnetic bead in reaction cup and three cleaning actions; Below the inner side of reaction cup rotating disc, be provided with annular magnetic bead adsorbent equipment, above the both sides of reaction cup rotating disc, be respectively equipped with several evenly mixing device.This device achieves the pipeline system cleaning of magnetic bead, and cleaning is cleaner, and magnetic bead loss is less, more optimized structure, controls simpler, possesses relatively independent function, be applicable to whole automated system.
Description
Technical field
The present invention relates to the magnetic bead cleaning device of Full-automatic chemiluminescence immunity class detection system or instrument, particularly a kind of Full-automatic chemiluminescence immunoassay analysis meter.
Background technology
Luminescence immunoassay is the novel ultramicro-analysis technology of one that luminesceence analysis and immune response are combined and set up.This technology utilizes chemistry or bio-luminescence system as the indication mechanism of antigen-antibody reaction, so as to the method for quantitative detectable antigens or antibody.The high sensitivity of this method with luminesceence analysis and the high degree of specificity of antigen-antibody reaction.Magnetic bead cleaning is not reactions steps in CLIA process, but determines the key of experiment success or failure.The object of cleaning be to wash away in reactant liquor the material that is not combined with antibody with solid phase antigen and in course of reaction non-specific adsorption in the interfering material of solid phase carrier.
At present, in existing full-automatic immunoluminescence analyzer, the absorption of most employing magnetic bead is extracted waste liquid and magnetic bead and is added cleaning fluid and mix the frame mode that two functions are separated, reaction cup needs to be moved around between the two positions by other servicing units, flow process is more complicated, is unsuitable for composition automation cleaning.
Summary of the invention
The object of the present invention is to provide a kind of magnetic bead cleaning device of Full-automatic chemiluminescence immunoassay analysis meter, achieve the pipeline system cleaning of magnetic bead, clean cleaner, magnetic bead loss is less, more optimized structure, controls simpler, solves the problem that the flow process of prior art existence is more complicated.
The present invention is achieved through the following technical solutions: a kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, it is characterized in that: comprise reaction cup rotating disc, lifting punch block, magnetic bead adsorbent equipment and evenly mixing device, described lifting punch block drives linearly slide rail vertically to move up and down by spindle motor, lifting punch block is provided with eight cleaning needle assemblies, wherein four pins are for telling liquid pin, for injecting cleaning fluid in reaction cup, four pins are aspirating needle, for drawing the waste liquid in reaction cup; Described eight groups of cleaning needles carry out the action of injection cleaning fluid to reaction cup successively and draw waste liquid action, realize once diluting the magnetic bead in reaction cup and three cleaning actions; Below the inner side of reaction cup rotating disc, be provided with annular magnetic bead adsorbent equipment, above the both sides of reaction cup rotating disc, be respectively equipped with several evenly mixing device.
Described reaction cup rotating disc is made timing rotation and is moved under the drive of motor and Timing Belt, rotating disc there are 32 reaction cup placement locations, can place 32 reaction cup simultaneously and carry out cleaning process, rotating disc turns over a reaction cup position clockwise every a fixed cycle.
Described evenly mixing device is by mixing friction pulley and micro-bearing jacking mechanism forms, and evenly mixing device has three groups, and mixing friction pulley lays respectively at micro-bearing jacking mechanism two side positions telling the corresponding reaction cup rotating disc of liquid pin 6c, 6e, 6g; Described evenly mixing device, by mixing the compound action of friction pulley and jacking mechanism, makes reaction cup both produce rotary motion, produces again and back and forth shake motion, thus the magnetic bead in reaction cup and cleaning fluid are fully mixed.
Described mixing friction pulley is quality of rubber materials, and its structure is eccentric wheel structure, and by driven by motor, it rotates.
Described micro-bearing jacking mechanism is made up of framework, spring, sliding axle bolster and micro-bearing, be slidably installed sliding axle bolster in the mouth of framework one end, spring is provided with between the rear end and the bottom of framework of sliding axle bolster, rotate in the front end of sliding axle bolster and micro-bearing is installed, this micro-bearing orientating reaction cup rotating disc side.
Described magnetic bead adsorbent equipment forms by fixing slide cartridge and the several spaced magnet be arranged in interior slide cartridge on a mounting board.
Described magnet is rubidium magnet, have 16, be arranged on respectively on interior slide cartridge relative to telling on liquid pin 6a and aspirating needle 6h position and totally 16 positions between the two thereof, wherein do not install magnet relative to telling on liquid pin 6c, 6e, 6g tri-positions, magnet is used for adsorbing the magnetic bead in reaction cup.
The invention has the beneficial effects as follows: integrate cleaning fluid injection, waste liquid sucking-off, Beads enrichment and magnetic bead and mix multi-functional, achieve the pipeline system cleaning of magnetic bead, cleaning is cleaner, and magnetic bead loss is less, more optimized structure, control simpler, possess relatively independent function, combine with corresponding liquid-way system, can be used as an independent magnetic bead cleaning module and use, comparatively speaking, it is applicable to whole automated system.
Accompanying drawing explanation
Fig. 1 is the overall perspective view of Multifunctional washing device of the present invention;
Fig. 2 is Multifunctional washing device generalized section of the present invention;
Fig. 3 is the perspective view of evenly mixing device of the present invention;
Fig. 4 is the perspective view of magnetic bead adsorbent equipment of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described.
The present invention Full-automatic chemiluminescence immunoassay analysis meter complete machine structure a specific embodiment as shown in Figures 1 and 2, comprising: reaction cup rotating disc 4, lifting punch block 5, magnetic bead adsorbent equipment 9 and the evenly mixing device be made up of mixing friction pulley 10, micro-bearing jacking mechanism 11.Concrete structure is made up of cleaning device installing plate 1, electric rotating machine 2, Timing Belt 3, reaction cup rotating disc 4, lifting punch block 5 and eight groups of cleaning needles (6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h), spindle motor 7, line slide rail 8, magnetic iron absorption device 9, mixing friction pulley 10, micro-bearing jacking mechanisms 11 etc.Lifting punch block 5 drives linearly slide rail 8 vertically to move up and down by spindle motor 7, lifting punch block 5 is provided with eight cleaning needle assembly 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, wherein 6a, 6c, 6e, 6g tetra-pins are for telling liquid pin, for injecting cleaning fluid in reaction cup, 6b, 6d, 6f, 6h tetra-pins are aspirating needle, for drawing the waste liquid in reaction cup, tell liquid pin 6a to aspirating needle 6b midfeather two positions, tell liquid pin 6c to aspirating needle 6d midfeather three positions, tell liquid pin 6e to aspirating needle 6f midfeather three positions, tell liquid pin 6g to aspirating needle 6h midfeather three positions.Reaction cup rotating disc 4 is made timing rotation and is moved under electric rotating machine 2 with the drive of Timing Belt 3, rotating disc there are 32 reaction cup placement locations, can place 32 reaction cup 12 simultaneously and carry out cleaning process, rotating disc turns over a reaction cup position clockwise every a fixed cycle.
As shown in Figure 3, evenly mixing device is by mixing friction pulley 10 and micro-bearing jacking mechanism 11 forms, and evenly mixing device has three groups, lays respectively at and tells the corresponding position of liquid pin 6c, 6e, 6g.Mixing friction pulley 10 is quality of rubber materials, and its structure is eccentric wheel structure, drives it to rotate by motor 13.
Described micro-bearing jacking mechanism 11(is located at the inner side of reaction cup rotating disc 4) be made up of framework 110, spring 111, sliding axle bolster 112 and micro-bearing 113, be slidably installed sliding axle bolster 112 in the mouth of framework 110 one end, spring 111 is provided with between the rear end of sliding axle bolster 112 and the bottom of framework 110, rotate in the front end of sliding axle bolster 112 and micro-bearing 113 is installed, this micro-bearing 113 orientating reaction cup rotating disc 4 side.
Mixing friction wheel from rotation 10, reaction cup 12 is driven to rotate, micro-bearing 113 on sliding axle bolster 112 surely leans against in reaction cup 12 under spring 111 acts on, when friction pulley 10 major axis is near reaction cup, extruding is produced to reaction cup, to jacking mechanism lopsidedness, Compress Spring, when mixing wheel minor axis and moving to reaction cup side, due to the restoring force of spring, driving a reaction cup is to mixing wheel lopsidedness, move and so forth, by the compound action of mixing friction pulley 10 with jacking mechanism 11, reaction cup is made both to produce rotary motion, produce again and back and forth shake motion, thus the magnetic bead in reaction cup and cleaning fluid are fully mixed.
As shown in Figure 4, magnetic bead adsorbent equipment 9 forms by fixing slide cartridge 901 and the magnet 902 be arranged in interior slide cartridge on a mounting board.Magnet used is rubidium magnet, have 16, be arranged on respectively on interior slide cartridge relative to telling on liquid pin 6a and aspirating needle 6h position and totally 16 positions between the two thereof, wherein do not install magnet relative to telling on liquid pin 6c, 6e, 6g tri-positions, magnet is used for adsorbing the magnetic bead in reaction cup.
Cleaning step is as follows: first reaction cup rotating disc 4 drives the reaction cup 12 put into wherein to be interrupted rotary motion clockwise, the every action of rotating disc once, the position of a mobile reaction cup 12, move to when telling liquid pin 6a position, tell liquid pin 6a and inject a certain amount of cleaning fluid in reaction cup, reactant liquor in diluting reaction cup, on magnetic iron absorption device, corresponding magnet carries out suction-operated to the magnetic bead in reaction cup simultaneously.After certain hour, rotating disc action three times, the i.e. position of mobile three reaction cup 12, reaction cup is taken to aspirating needle 6b position, aspirating needle 6b declines, by the waste liquid exhaustion in reaction cup, then rotating disc action once, move to and tell liquid pin 6c place, inject quantitative cleaning fluid, evenly mixing device carries out mixing action to reaction cup simultaneously, after having mixed, rotating disc drives reaction cup to enter next magnetic suck flow process, through aspirating needle 6d, tell liquid pin 6e, aspirating needle 6f, tell liquid pin 6g and twice mixing action, finally by the waste liquid drawn by aspirating needle 6h in reaction cup, complete whole cleaning process.Now reaction cup can be taken out via other structures of instrument, carries out next step action.In whole cleaning process, altogether once dilution and three cleaning actions are carried out to the magnetic bead in reaction cup, ensure that magnetic bead can be cleaned up, many group rubidium magnet is used to carry out absorption action to magnetic bead, ensure that aspirating needle is when drawing waste liquid, magnetic bead loss reduction, the clockwise interval motion of simultaneous reactions cup rotating disc, when carrying out a reaction cup fluid injection mixing action, the action of absorption waste liquid can be carried out to next reaction cup, thus define the cleaning process multiple reaction cup being carried out to pipeline system, flow process is more optimized, controls simpler.
Claims (7)
1. a Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, it is characterized in that: comprise reaction cup rotating disc, lifting punch block, magnetic bead adsorbent equipment and evenly mixing device, described lifting punch block drives linearly slide rail vertically to move up and down by spindle motor, lifting punch block is provided with eight cleaning needle assemblies, wherein four pins are for telling liquid pin, for injecting cleaning fluid in reaction cup, four pins are aspirating needle, for drawing the waste liquid in reaction cup; Described eight cleaning needle assemblies carry out the action of injection cleaning fluid to reaction cup successively and draw waste liquid action, realize once diluting the magnetic bead in reaction cup and three cleaning actions; Below the inner side of reaction cup rotating disc, be provided with annular magnetic bead adsorbent equipment, above the both sides of reaction cup rotating disc, be respectively equipped with several evenly mixing device.
2. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 1, it is characterized in that: described reaction cup rotating disc is made timing rotation and moved under the drive of motor and Timing Belt, rotating disc there are 32 reaction cup placement locations, can place 32 reaction cup simultaneously and carry out cleaning process, rotating disc turns over a reaction cup position clockwise every a fixed cycle.
3. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 2, it is characterized in that: described evenly mixing device is by mixing friction pulley and micro-bearing jacking mechanism forms, evenly mixing device has three groups, and mixing friction pulley lays respectively at micro-bearing jacking mechanism two side positions telling the corresponding reaction cup rotating disc of liquid pin 6c, 6e, 6g; Described evenly mixing device, by mixing the compound action of friction pulley and jacking mechanism, makes reaction cup both produce rotary motion, produces again and back and forth shake motion, thus the magnetic bead in reaction cup and cleaning fluid are fully mixed.
4. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 3, it is characterized in that: described mixing friction pulley is quality of rubber materials, its structure is eccentric wheel structure, and by driven by motor, it rotates.
5. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 3, it is characterized in that: described micro-bearing jacking mechanism is made up of framework, spring, sliding axle bolster and micro-bearing, be slidably installed sliding axle bolster in the mouth of framework one end, spring is provided with between the rear end and the bottom of framework of sliding axle bolster, rotate in the front end of sliding axle bolster and micro-bearing is installed, this micro-bearing orientating reaction cup rotating disc side.
6. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 1, is characterized in that: described magnetic bead adsorbent equipment forms by fixing slide cartridge and the several spaced magnet be arranged in interior slide cartridge on a mounting board.
7. Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device according to claim 6, it is characterized in that: described magnet is rubidium magnet, have 16, be arranged on respectively on interior slide cartridge relative to telling on liquid pin 6a and aspirating needle 6h position and totally 16 positions between the two thereof, wherein do not install magnet relative to telling on liquid pin 6c, 6e, 6g tri-positions, magnet is used for adsorbing the magnetic bead in reaction cup.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310522625.XA CN103599898B (en) | 2013-10-29 | 2013-10-29 | Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device |
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| CN201310522625.XA CN103599898B (en) | 2013-10-29 | 2013-10-29 | Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device |
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| CN103599898A CN103599898A (en) | 2014-02-26 |
| CN103599898B true CN103599898B (en) | 2015-11-25 |
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| CN202263743U (en) * | 2011-10-20 | 2012-06-06 | 上海蓝怡科技有限公司 | Cleaning device for magnetic bead particles |
| CN102998473A (en) * | 2012-12-19 | 2013-03-27 | 北京利德曼生化股份有限公司 | Full-automatic chemiluminescence immune analyzer |
| CN103230897A (en) * | 2013-04-23 | 2013-08-07 | 上海裕隆生物科技有限公司 | Cleaning device and cleaning method |
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