CN103520302A - Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof - Google Patents
Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health care medicine, specifically to an anti-fatigue capsule with a sea-buckthorn leaf or an extract thereof as a main raw material and a preparation method thereof. To overcome a technical problem, the invention provides an anti-fatigue health-care capsule with the sea-buckthorn leaf as a main raw material and a preparation method thereof. According to a technical scheme provided by the invention, the sea-buckthorn leaf anti-fatigue capsule comprises the following raw materials by mass: 500 to 550 parts of the sea-buckthorn leaf, 180 to 200 parts of rhodiola root, 100 to 150 parts of prepared fleece flower root, 80 to 100 parts of dogwood, 60 to 80 parts of milkvetch root, 40 to 60 parts of eucommia bark, 50 to 60 parts of epimedium, 40 to 60 parts of tree peony bark, 30 to 40 parts of ginseng and 20 to 30 parts of calcium gluconate. The above-mentioned raw materials undergo crushing, extraction, freeze drying, mixing, granulation, drying, sterilization and capsule filling so as to prepare a finished anti-fatigue capsule product.
Description
Technical field
The present invention relates to health care medicine, be specifically related to a kind of antifatigue capsule that Folium Hippophae or its extract be main material and preparation method thereof of take.
Background technology
Fatigue is obviously sensation tired out and unconformable of human body spirit and muscle power, and its clinical manifestation is commonly encountered diseases, frequently-occurring disease, is anosis or little pathogenetic omen and increase the weight of.Fatigue can be excessive because of mental work, and especially elderly knowledge technology is key; Also can be excessive because of physical work, the shop floor worker such as railway ,Gong road, municipal administration, modernization real estate market building especially; Office clan's long-term work and overtime work; Long-term does not have enough sleep; Momental minimizing; Bad living habit, as smoke and drink, the place amusement such as long-term KTV; Diet is irregular, fat-reducing is cultivated one's moral character, malnutrition, have a delicate constitution, cause power generation not enough, overrun; Long-term sorrow is pondered over, and neural excitation is excessively strong, long, and thinking is nervous, causes cerebral anoxia and produces neuroinidia and fatigue; The work rhythm and pace of moving things is accelerated, and pressure is excessive, grueling warfare, and hyperkinesia, physical demands is excessive, and muscle lactic acid and metabolite overheap thereof cause that muscle tone declines, and motion durability reduces, and energy expenditure too much produces tired; High altitude anoxia district work etc. all can cause out short-term, irregular or long-term fatigue phenomenon; Weak, prolonged illness, sap one's vitality, negative and positive of qi and blood metabolic imbalance etc. all can produce fatigue.Therefore, fatigue is subhealth state and ill general performance.
In fact, numerous disease, as tinnitus, dizzy, forgetful, cardiopalmus, insomnia, menoxenia, drowsiness, fear of cold, weakness of the lower extremities, climacteric syndrome, hypoimmunity, computer air conditioner comprehensive is levied, blood deficiency, the deficiency of vital energy, the deficiency of YIN, yang deficiency, hypertension, coronary heart disease, hyperlipidemia, fatty liver, diabetes, gastric ulcer, chronic gastritis, viral hepatitis, chronic cholecystitis, asthma, chronic bronchitis, chronic pulmonary heart disease, congestive heart failure, thrombophlebitis, senile dementia disease, depression, obesity, trimester of pregnancy, vaginitis, uterine prolapse, rheumatoid, renal failure, weakness of the lower extremities, vasculitis, varicosis, cancer middle and late stage etc., there is the feeling of fatigue that shows in various degree.
If tired, can not adjust in time, treat, the pathological changes of a series of nerves, endocrine, immunity and internal organs makings can occur.In addition, can there is fatigue in various degree to certain phase in every disease progression, increases the weight of development and the deterioration of the state of an illness.Therefore pay attention to prevention, alleviate, treat all measures that can cause that fatigue occurs, as healthy thinking, strike a proper balance between work and rest, fully rest, nourishing healthy, environmental health, suitably take exercise, appropriateness is built up one's health by taking tonic etc., all to eliminate subhealth state, prevent disease, the effective measures of relieving fatigue.
Modern Chinese medicine thinks, fatigue is the deficiency syndrome that consumption is hindered vigour, is that spirit is unbalance, due to the smooth double factor of psychology.Having its cause of disease, pathogenesis, is a kind of chronic synthetic disease, is mostly attributed to subhealth state category.Chase after its root, they all relate to the vital organs of the human body, are mainly that brain (nerve), spleen, liver, stomach, kidney are main.Can be by conditioning will, tired the calming the nerves of dispelling, brain-strengthening oxygenating, tonify deficiency righting, nourishes the methods such as primordial QI reinforcing, the object of reach prevention, controlling and treat.
Maintaining healthy be at all to keep for a long time psychology and physiological balance and health.Stablize the phychology emotion that keeps good, form good living habit, strike a proper balance between work and rest, meat and vegetables collocation balance, absorbs water fruit vegetable more, strengthens taking exercise, and improves self body constitution and immunocompetence.
Fructus Hippophae is to administer in the world at present desertification, desertification, barren deserted mountain, barren hill, classic pioneer's economic tree.In long-term and natural harsh and unforgiving environments struggle, its fruit, stem and leaf have accumulated a large amount of nutrition and degeneration-resistant border allelochemical, except not containing V
dcontain all other natural complex, and quantity is maximum outward; Containing 8 seed amino acids of high protein and needed by human, rich content, reasonable mixture ratio; High containing unsaturated fatty acid (linoleic acid, linolenic acid) quantity, best (1:0.9) physiology of proportioning, pharmacological function are obvious; Containing multiple polyphenoils, as tea polyphenols, catechin, flavone, polyphenol, beta-carotene, triterpene, sterol, serotonin etc., higher than other plant; The major function of fruit, stem and leaf is: energy blood circulation promoting and blood stasis dispelling, soothing liver and strengthening spleen, relieving cough and asthma, the antibacterial granulation promoting of antiinflammatory, resisting fatigue, raising immunity, Guben Baoyuan, Radix Stephaniae Tetrandrae is sick, preventive treatment of disease, can effectively correct subhealth state, and various diseases is had to significant prevention, therapeutic effect.In the medicine of Tibet, lama claims that Fructus Hippophae is " miraculous cure ", " the holy fruit " being guaranteed to cure all diseases.Therefore, the medicinal of Fructus Hippophae mainly be take Fructus Hippophae, Folium Hippophae, juice of Fructus Hippophae, Fructus Hippophae flavone, Oleum Hippophae as main.Modern Fructus Hippophae health drink is also primary raw material mainly with Fructus Hippophae.The utilization of Folium Hippophae is limited to making hippophae rhamnoides tea at present substantially, but finds in the clinical and pharmacological testing of nearly more than 10 years, and the effective ingredient that it is contained and function, much larger than Fructus Hippophae, are the important source material of Fructus Hippophae food, department of health, drug research and development from now on.
Summary of the invention
The present invention overcomes the deficiencies in the prior art, and technical problem to be solved is to provide a kind of take anti-fatigue health-caring capsule that Folium Hippophae is primary raw material and the method for preparation.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of Folium Hippophae antifatigue capsule, comprises the raw material of following mass distribution ratio: Folium Hippophae 500-550 part, Radix Rhodiolae 180-200 part, Radix Polygoni Multiflori Preparata 100-150 part, Fructus Corni 80-100 part, Radix Astragali 60-80 part, Cortex Eucommiae 40-60 part, Herba Epimedii 50-60 part, Cortex Moutan 40-60 part, Radix Ginseng 30-40 part, calcium gluconate 20-30 part.
The preparation method of above-mentioned Folium Hippophae antifatigue capsule, comprise the following steps: by 9 kinds of herbal raw materials of described mass distribution ratio through all in advance roguing, dust removal, pulverizing, mixing, mixed material is adopted to 80% edible ethanol material in mass ratio: solution=1:15-25 soaks 1-1.5h, then under temperature 60 C, extract continuously 2-4h; By extracting solution after filtration, concentrated, the dry herbal raw material elite extract that obtains, and then compare compatibility by prescription quality, described herbal raw material elite extract is mixed homogeneously with described calcium gluconate, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
As preferred a kind of Folium Hippophae antifatigue capsule, herbal raw material Folium Hippophae in described raw material, Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Corni, the Radix Astragali, the Cortex Eucommiae, Herba Epimedii, Cortex Moutan, Radix Ginseng all directly adopt the extract side of entering, and by extract weight, that is:
Folium Hippophae extract 500-550 part, Radix Rhodiolae extract 180-200 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Fructus Corni extract 80-100 part, Radix Astragali extract 60-80 part, Cortex Eucommiae extract 40-60 part, Herba Epimedii extract 50-60 part, Cortex Moutan extract 40-60 part, Radix Ginseng extract 30-40 part, calcium gluconate 20-30 part.
The preparation method of above-mentioned Folium Hippophae antifatigue capsule, comprise the following steps: respectively by the decoction pieces of described 9 kinds of herbal raw materials through roguing, dust removal, pulverizing, material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:15-25 soaks 1-1.5h, then at temperature 50-65 ℃, extract continuously 2-4h; By extracting solution after filtration, concentrated, dry, obtain 9 kinds of herbal raw material extracts; Press again prescription mass ratio, described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
In order to improve extraction efficiency and precision and better to protect effective ingredient not make it to run off, the present invention has also done following optimization to above-mentioned preparation method:
The optimum condition of described continuous extraction is for loading 120 revs/min of ultrasound wave, mechanical agitation, the air compressor machine airflow stirring of 3kw power;
Described extracting liquid filtering method preferably adopts duplex strainer to filter;
Extracting solution after described filtration is concentrated into quality than solid content: solvent=1:2-3 through vacuum diaphragm, then through frozen drying powdered, obtains herbal raw material elite extract.
One, design principle of the present invention:
Fatigue is the subhealth state that causes of many reasons and ill general performance, produce tired basic reason, that internal and external factor causes koinomatter metabolism, energy metabolism, Information Conduction between viscera to lose balance, produced disorder, and then make the nerve-endocrine-immunological network of balance the body essence, gas, god, type lose balance, show following aspect:
Deficiency of kidney-essence---can not activating QI hemopoietic, spirit is tired, soreness of the waist and knees;
Depression of liver-QI---the liver failing to maintain the normal flow of QI, causes depressed emotion, loss of appetite, and menoxenia, dysmenorrhea, amenorrhea, weak;
Stagnation of dampness due to deficiency of the spleen---insufficiency of generating and transforming QI and blood, neurolysis, heaviness of the head and fatigue of the body, fatigue and weak;
Asthenia of both the spleen and kidney---the sun of damage spleen kidney, causes essence tired drowsy, and body is tired weak, deficiency of QI with disinclination to talk:
Deficiency of both the heart and spleen---because of eating and drinking without temperance, work with one's mind excessively, secretly consume cloudy blood, cause deficiency of heart-blood, insomnia and dreamful sleep, shortness of breath and fatigue;
Deficiency of qi and blood---congenital defect, prolonged illness consume, old consumption wound, the work that causes not enduring hardships, palpitation and short breath, smart tired power;
Disarmony between the heart and kidney---prolonged illness asthenia, sexual strain, palpitation with fear insomnia, dizzy tinnitus, soreness of the waist and knees.
For this reason, main direction of the present invention is: primordial QI reinforcing is mended essence, blood-enriching qi-invigorating, tonify deficiency righting, tired the calming the nerves of dispelling.And as target, through repeatedly probing into and testing, determined above-mentioned prescription.
Two, prescription element pharmacology of the present invention is introduced with compatibility and is resolved:
1, compatibility is resolved
Monarch drug----Folium Hippophae;
Ministerial drug---Radix Rhodiolae, Radix Polygoni Multiflori Preparata;
Adjuvant drug---Fructus Corni, the Radix Astragali, Herba Epimedii, Radix Ginseng, the Cortex Eucommiae;
Make medicine---Cortex Moutan, calcium gluconate.
The function of above-mentioned each component of prescription is:
Folium Hippophae: strengthening the body resistance, spleen-invigorating stomach-protecting, protect the liver kidney tonifying, carry gas tonify deficiency, resisting fatigue, improves immunity;
Radix Rhodiolae: excitor nerve, allaying tiredness, kidney-replenishing blood-nourishing, blood circulation promoting and blood stasis dispelling;
Radix Polygoni Multiflori Preparata: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening;
Fructus Corni: YIN nourishing, anoxia enduring, resisting fatigue, raising stress ability, prevent and treat osteoporosis, improve immunity;
The Radix Astragali: carry that superficies-consolidating, arresting sweating are admittedly de-, blood pressure lowering, enhancing immunity, protect the liver antiviral, resisting fatigue;
Herba Epimedii: tonifying YANG, the kidney invigorating, bone and muscle strengthening, wind-damp dispelling;
Radix Ginseng: invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, nourishing blood to promote the production of body fluid;
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, hypertension and hyperlipemia, protection cardiovascular, prevention of obesity, antiinflammatory antiviral, enhancing immunity, slow down aging, resisting fatigue;
Cortex Moutan: regulate nerve, taste, liver and gall, kidney, coordinating the actions of various ingredients in a prescription to be to reach internal organs, to reach tired the calming the nerves of dispelling, brain-strengthening oxygenating, the effect of tonify deficiency righting;
Calcium gluconate: replenish the calcium, antiallergic, convulsions, adjusting metabolic balance, correct some drugs poisoning.
2, prescription component pharmacology and effect
(1) Fructus Hippophae: Fructus Hippophae Xi Meng, Tibetan medicinal herbs most in use, existing several thousand above history, is put into the Pharmacopoeia of the People's Republic of China for 1977.Its function is eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.For cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, blood stasis amenorrhea, falls the effect of flutterring congestive edema.
Modern science research shows, Folium Hippophae, Fructus Hippophae, seed of Fructus Hippophae all do not have overt toxicity, and acute toxicity test shows, the LD of oral Fructus Hippophae water extract
50be greater than 10g/kg body weight, belong to the food without genotoxic potential.Fructus Hippophae rich in proteins and aminoacid, unsaturated fatty acid, mineral, trace element, vitamin are (except not containing V
doutward, it is containing all vitamin (therefore claiming vitamin plant).It is grown in the extremely frigid zones of height above sea level 800-4000m what is more important, and under the harsh condition such as large dust storm, intense light irradiation, ultraviolet, high temperature difference (50 ~ 50 ℃), serious water shortage, few fertilizer, disease and pest, it has been survived more than 200,000,000 year.In order to adapt to living environment, cylinder accumulation a large amount of resistance compounds, as physiology, pharmaceutically active compounds such as organic acid, flavonoid, tea polyphenols, catechin, polyphenol, terpenoid, steroid class, beta-carotene, procyanidin, serotonins.There is the human body of promotion growth promoter, improve IQ, improve immunologic function, blood fat reducing, blood pressure lowering..The generation of blood sugar lowering prevent diabetes and complication thereof.Spleen, stomach, liver, kidney, cardiovascular and cerebrovascular vessel are had to significant protective effect.Accelerate gastric emptying speed, strengthens duodenum contraction intensity.There is relieving constipation, promote enterokinesia effect.Improve calcium, phosphorus utilization, improve the effect of strengthening sclerotin.Bacteriostasis.Radioprotective, antioxidation is removed O2
-, HO
-, O2 free radical ability.There is short lead-eliminating effect.Have antalgic and inflammation relieving and strengthen hypoxia-bearing capability and anti-fatigue ability, anti-cerebral anoxia, improves Na+-K+-ATP enzyme in its cerebral tissue, Ca2+-ATP enzymatic activity, reduces LD content.Anti-aging effects.In addition, Fructus Hippophae also has significant tumor killing effect, to the tumour inhibiting rate of solid tumor mice, up to 46 ~ 58%, is mainly the immunologic function that has strengthened mice, has improved spleen index and thymus index.
In a word, the Fructus Hippophae property of medicine is gentle, strengthening the body resistance, carry gas tonify deficiency, resisting fatigue, improves immunity, with deficiency tonifying kind medicine compatibility, to spleen, liver, lung, kidney, the heart, nerve, be all to occupy the 2nd in the sequence of a kind of positive adjustment, nourishing function effect ，Yi world health product, it is the raw material that a kind of medicine-food two-purpose health preserving of preciousness is cured a disease.
(2) Radix Rhodiolae: Radix Rhodiolae is called " plateau Radix Ginseng ", and its main chemical compositions has rhodioside, butyl alcohol and Radix Rhodiolae polysaccharide, and contain flavone compound, phenolic compound, protein, fat, trace volatile oil and trace element, aminoacid etc.Be grown in height above sea level 800---the rare wild plant in 2500 meters of high and cold pollution-free areas.Because its growing environment is severe, as anoxia, low temperature, dry, blast, be subject to ultraviolet radiation, day and night temperature large, thereby there is very strong vitality and special adaptability.For the conventional traditional medicine in Asia, there is excitor nerve system, increase the effects such as work efficiency, allaying tiredness and prevention high mountain disease.Shennong's Herbal points out, the Radix Rhodiolae QI invigorating of making light of one's life by commiting suicide, does not prolong life always, nontoxic many clothes, and clothes are not hurted sb.'s feelings for a long time, can the kidney invigorating, regulate the flow of vital energy and nourish blood, cure mainly the whole body weak, uncomfortable in chest etc., also there is the effect under promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, analgesic and leukorrhagia stopping.Tibetan medicine's Four-Volume Medical Code is recorded, Radix Rhodiolae " property is flat, puckery, kind lung moistening, can the kidney invigorating, regulate the flow of vital energy and nourish blood, cure mainly the diseases such as the whole body is weak, uncomfortable in chest, nauseating, body is empty." Jingzhubencao " speech, " Radix Rhodiolae is invigorated blood circulation, and lung heat clearing, cough-relieving are brought down a fever, pain relieving, be used for the treatment of pneumonia, tracheitis, physical weakness, malaise, uncomfortable in chest, be difficult to breathe freely, lip and the palm of the hand blue ".It is " in known tonic, institute is rare " that Compendium of Material Medica is recorded " Radix Rhodiolae, eliminating evil bad odor are mended various symptoms and signs of deficiency "." acid of Herba hylotelephii erythrosticti bitter in the mouth is flat, nontoxic for supplement to Thousand Golden Prescriptions speech.Main large hot large carbuncle(disease), fever of the body is tired, evil gas, all diseases due to noxious agents produced by various parasites crust arranges, cold and heat migratory arthralgia, various symptoms and signs of deficiency, main woman's whitish metrorrhagia, clear body improving eyesight, the logical god of clothes is not old for a long time." powder stick is recorded in " modern Practical Chinese medicinal Quality Control Technology ", " Chinese medicine complete works of ": Radix Rhodiolae function with cure mainly: " heat-clearing and toxic substances removing, dampness.For lung-heat, pestilence, limb edema." " Chinese medicine voluminous dictionary " record: Radix Rhodiolae " cold in nature, sweet-puckery flavor.Promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Control hemoptysis, spitting of blood, pneumonia cough." " modern practical book on Chinese herbal medicine " say that its effect has " having resisting fatigue, heart tonifying, antiinflammatory, inhibition blood sugar increasing, anti-peroxidation, resisting microwave radiation effect "." Chinese herbal medicine is commonly used in Tibet ": Radix Rhodiolae also has the effect under promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, analgesic and leukorrhagia stopping.Cure mainly the diseases such as hemoptysis, pneumonia cough, women leucorrhea.Meridian distribution of property and flavor, sweet, hardship, flat; Return lung, heart channel.Function with cure mainly benefiting QI for activating blood circulation, promote blood circulation and relieving asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.
Modern science research shows, Radix Rhodiolae has strengthening the body resistance, YIN and YANG balance regulating, vigorate qi and replenish the blood, nourishing the brain and improving intelligence, anti-hypoxia, resisting fatigue, two-ways regulation, defying age, radioprotective, nervous system regulation, cardio-cerebrovascular and immunity and antitumor action.
(3) Herba Epimedii: Herba Epimedii is a kind of traditional medicine-food two-purpose tonic, has very high medical value, and taste acrid, sweet, warm, return liver, kidney channel.Cure mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Contain the various active chemical compositions such as flavonoid, polysaccharide, volatile oil, lignanoid, trace element, alkaloid.The main effect of active component of Herba Epimedii is kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, and waist knee joint flaccidity is soft, cold extremities with aversion to cold, rheumatic arthralgia, numbness contracture, climacteric hypertension.Be used for suffering from a deficiency of the kidney and can join Fructus Corni, Radix Angelicae Sinensis, the Radix Astragali and Radix Ginseng.There is stronger pharmacological action the aspects such as Herba Epimedii can improve immunity, increases bone metabolism, improves cardio-cerebrovascular, antioxidation, antitumor, gonadotropic Effect.
The demonstration of recent studies result, Herba Epimedii has good effect aspect resisting fatigue, raising motor capacity.Herba Epimedii can be by improving the restitution that extremely carrys out hemopoietic of hematopoietic regulation factor secretion.Epimedium brevicornum polysaccharide has obvious resisting fatigue, anoxia enduring effect.Epimedium brevicornum polysaccharide is to improving immune effect highly significant.Herba Epimedii total flavones can improve bone density.Total flavones can suppress the loss of castrated rats calcium, phosphorus.Herba Epimedii total flavones has more significant extracorporeal antivirus effect effect.Herba Epimedii can promote hemopoietic function, resists myocardial ischemia, heart failure resistance, arrhythmia, atherosclerosis, blood pressure lowering, antitumor, defying age, adjusting immunity and the effect of improving bone metabolism, and at antioxidation and improve the aspects such as hemorheology and have good effect.Icariin and icariside II all have certain scavenging action to hydroxy radical, lipid peroxidation.Herba Epimedii total flavones metabolite has promoting bone growing activity.The compatibilities such as Herba Epimedii and Radix Polygoni Multiflori, Fructus Lycii, Fructus Corni, Herba Cistanches, Radix Rehmanniae Preparata, can treat less, azoospermia, and clinical efficacy is obvious.Epimedium brevicornum polysaccharide has obvious resisting fatigue, anoxia enduring, the prevention of sports fatigue and recovery is had to remarkable effect.
(4) Radix Astragali: Radix Astragali sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.Have that consolidating superficial resistance and supplementing qi, diuretic detumescent, arresting sweating are admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema, enhancing human body immunity function, have protect the liver, antiviral property myocarditis, the resisting fatigue that strengthens, antiulcer, antitumor, osteoporosis, diuresis, defying age, anti-stress, blood pressure lowering and more antibiotic effect.In Chinese medicine, the Radix Astragali is QI invigorating good merchantable brand.
Modern science research, the Radix Astragali is evident in efficacy in the insomnia of the kidney invigorating YANG hyperactivity suppressing treatment climacteric.It is definite that Radix Astragali Umbellate Pore Decoction is treated intractable membranous nephropathy clinical efficacy.Astragalus polysaccharides has good interior antioxidation action, can slow down aging.The Radix Astragali and Fructus Corni, Herba Epimedii, Radix Salviae Miltiorrhizae compatibility, effective to improving renal failure.The Radix Astragali and Radix Rehmanniae Preparata, Herba Epimedii compatibility, obvious to the effect for the treatment of diabetes osteoporosis.Radix Astragali superfine powder has the function that strengthens immunity, resisting fatigue.Astragalus root fermentation liquor through lactic acid bacteria fermentation has resisting fatigue and anti-oxidation health function.Astragaloside has anti-fatigue effect.Radix Astragali aqueous extract can improve the anti-fatigue ability of mice and improve antiradical activities.Compound Radix Astragali polysaccharide equally also has resisting fatigue and resisting oxygen lack.Astragalus polysaccharides can improve the tolerance to cold of mice under low temperature environment, reduces mortality rate, extends mice swimming time, improve anti-fatigue ability, extend mice Hypoxia under normal pressure, improve hypoxia-bearing capability, make serum activity of SOD obviously raise, MDA content obviously reduces simultaneously.The genuine Radix Astragali aqueous extract in Changbai Mountain may play antifatigue effect by the metabolism that increases the deposit of muscle glycogen and slow down phosphagen.
(5) Fructus Corni: Fructus Corni is the conventional rare Chinese medicine of China, sour in the mouth is puckery. slightly warm in nature.Enter liver, kidney two warps.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin that physiologically active is stronger, has and strengthens immunity, memory reinforcing, antiinflammatory, the effect such as antibiotic.
The demonstration of recent studies result, Fructus Corni decocting liquid can improve the ability of mice anoxia enduring, resisting fatigue, stress.Fructus Corni pit water extract also has antifatigue effect.Fructus Corni water extraction liquid has the osteoporotic effect of control.Fructus Corni can significantly strengthen cellular immunization, the humoral immune function of mice, promotes mouse thymus to grow and proliferation, and significantly improves the exercise tolerance of mice.
(6) Radix Polygoni Multiflori: be loaded in<Kaibao Bencao of Radix Polygoni Multiflori beginning>, be the dried root of polygonum multiflorum thunb, its slightly warm in nature, bitter in the mouth, sweet, puckery. clinical practice have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata not. Radix Polygoni Multiflori can detoxify, eliminating carbuncle, loosening bowel to relieve constipation. cure mainly scrofula infections carbuncle sore, rubella pruritus, dryness of the intestine constipation. the invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, cures mainly blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body is empty.
Modern science result of study shows, what head contains anthraquinone component, total sugar, lecithin, psoralen, isopsoralen, two ethylene glycosides, black stilbene glucoside, w-hydroxyemodin, emodin, physcione, normal-butyl-Beta-D-Fructopyranose, Semen Cassiae ketone-8-O-β-D-pyranglucoside etc.
Single Radix Polygoni Multiflori Preparata medicine Contained Serum has the proliferation function that stimulates osteoblast cultured in vitro.The effects such as Radix Polygoni Multiflori Preparata has defying age, antibiotic, antiinflammatory, blood fat reducing, blood sugar lowering, protects the liver, neuroprotective.Radix Polygoni Multiflori chrysophanic acid can be removed hydroxy radical.New chemical composition contained in Radix Polygoni Multiflori Preparata is probably the product of maillard reaction, so Radix Polygoni Multiflori Preparata has better nourishing blood function compared with Radix Polygoni Multiflori.According to the evaluation principle of medicine pharmacological action and evaluation criteria, Radix Polygoni Multiflori is carried out to document to the pharmacological action of teenager memory and resisting fatigue and revalue, with the obvious effect of clear and definite its hypermnesis and resisting fatigue.Radix Polygoni Multiflori can strengthen the ability of mouse anti-reflecting fatigue and anoxia enduring, strengthens the adaptive capacity to hot environment.
(7) Cortex Eucommiae: the Cortex Eucommiae is the distinctive economic plant resources of China, belongs to national two class protective plants.Mainly comprise the chemical compositions such as lignanoids, iridoids, organic acid, gutta-percha, motherland's medical science is thought, Cortex Eucommiae sweet in the mouth, micro-pungent, warm in nature has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.The Cortex Eucommiae contains the number of chemical compositions such as Phenylpropanoid Glycosides compound, lignin, iridoids, polysaccharide, flavonoid.And there is blood pressure lowering, blood sugar lowering, and regulate blood fat, anticancer, press down cancer, enhancing immunity, suppresses cholesterol and rises, anticomplementary activity, mutation, the pharmacological action of the aspects such as antioxidation.The Cortex Eucommiae contains chlorogenic acid, and chlorogenic acid has antiinflammatory, antioxidation, antimutagenic, antiviral, bacteriostasis, prophylaxis of tumours, treatment diabetes and cardiovascular protection effect etc.
The antifatigue effect result of study that Folium Eucommiae extract exhausts motion and recovery mice to power shows, can raising power exhaust SOD, POD activity in motion and return to form lower mouse liver, heart, quadriceps femoris, reduce MDA and generate, show that Cortex Eucommiae extract exhausts motion to power and recovery mice has antifatigue effect.Modern pharmacological research shows, Folium Eucommiae has blood pressure lowering, regulates blood fat, cardiovascular protection, prevention of obesity, antiinflammatory, antiviral, enhancing immunity, slow down aging, fatigue-resisting function. Folium Eucommiae is mainly used in blood pressure lowering, treats obstetrical and gynecological disease etc. clinically.
(8) Radix Ginseng: Radix Ginseng be have won fame both at home and abroad, rare medicinal herbs that old children all knows.
Radix Ginseng contains more than 30 plants ginsenoside, triterpenoid compound (panoxadiol, panaxatriol), organic acid (citric acid, 1-Hydroxy-1,2,3-propanetricarboxylic acid., Fumaric acid, ketoglutaric acid, malic acid etc.), esters (oleic acid, linoleic acid, triglyceride, Palmic acid), vitamin (vitamin B1, vitamin B2, vitamin B12, vitamin C, nicotinic acid, folic acid, pantothenic acid, biotin and nicotinic acid amide), sterol and glycoside thereof (cupreol, stigmasterol, daucosterol, campesterol, ginsenoside P and ester sterol) etc.Radix Ginseng sweet in the mouth, micro-hardship, slightly warm in nature, returns spleen, lung, the heart, kidney channel; There is invigorating QI to relieve exhaustion, spleen invigorating lung benefiting, mind calming Fructus Alpiniae Oxyphyllae, the effect of nourishing blood to promote the production of body fluid.Radix Ginseng cures mainly serious disease, prolonged illness, loses blood, vigour wish is de-due to de-liquid, Mental fatigue faint pulse; The lack of appetite asthenia of deficiency of spleen-QI, vomiting is had loose bowels; The dyspnea with shortness of breath of insufficiency of lung-QI, coughs unable; The insomnia and dreamful sleep that insufficiency of heart-QI declines, palpitates with fear forgetful, the empty hyperhidrosis of body; Body fluid deficiency thirsty, quenches one's thirst; Blood deficiency sallow, dizzy; Impotence due to deficiency of the kidney, frequent micturition, deficiency of vital energy diseases caused by exogenous pathogenic factor.The applicable crowd of Radix Ginseng has physical weakness, insufficiency of vital energy and blood, breathes hard, anemia person, neurasthenia.
(9) Cortex Moutan: Cortex Moutan is the root bark of Paeonia suffruticosa, cold in nature, bitter in the mouth, cool, be slightly cold.GUIXIN; Liver; Kidney; Lung meridian.Be antipyretic, there is clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Rheumatism pyretic arthralgia.The Quercetin, kaempferide, isorhamnetin, catechin, peoniflorin, caffeic acetate, apigenin, salvianolic acid A methyl ester, salvianolic acid N, rosmarinic acid, salvianolic acid A, alkannic acid B methyl ester, salvianolic acid B, galloylpaeoniflorin, succinic acid, the volatile oil that in Cortex Moutan, contain gallic acid, 5 hydroxymethyl furfural, flavones ingredient, wherein in volatile oil, contain 20 compounds, peonol content is maximum.That Cortex Moutan has is anticancer, antianaphylaxis asthma, protect the liver, atherosclerosis, antiinflammatory, the damage of anti-myocardial reperfusion, improve many-sided pharmacological actions such as cognitive disorder, neuroprotective.
Compared with prior art the present invention has following beneficial effect.
1, the present invention be take Folium Hippophae extract as monarch drug, take Radix Rhodiolae extract as ministerial drug, guaranteed resisting fatigue, anti-hypoxia curative effect, take other 8 kinds of Chinese medicines is adjuvant, has regulated tired the calming the nerves of dispelling of nerve, taste, liver and gall, kidney, brain-strengthening oxygenating, tonify deficiency righting, the comprehensive function of nourishing primordial QI reinforcing, has shown that the function center of prescription is to take righting primordial QI reinforcing as main, regulate metabolic balance, in righting, reach the effect that resisting fatigue is got rid of evils.
2, at present for the application of Folium Hippophae, mainly take tea making and beverage as main, being used as medicine is main mainly with Fructus Hippophae, adopts the Folium Hippophae person of being used as medicine few; Prescription of the present invention has taken into full account the property of medicine of Folium Hippophae composition, and reasonable compatibility, carefully solves, and combines multiple tonification Chinese herbal medicine, has been made into a kind of brand-new Chinese medicinal formulae; Simultaneously for a new approach has been pointed out in the utilization of Folium Hippophae.
3, the present invention all adopts the Chinese crude drug of integration of edible and medicinal herbs, and adopt modern extracting method, discard the dross and select the essential, realized " Chinese medicine westernization ", reform prescription, with the extract side of entering, both reduced patent medicine volume, greatly improve again active constituent content, and improved the snap action of dose-effect and timeliness.
4, this formula is at universe side's group medicine under Chinese medical theory " monarch " instructs, and carry out pharmacology, toxicological test, and crowd takes and completes in experimental basis, and test data is complete, and real result is credible, and effect has cogency.
5, this prescription both instructed with Chinese medical theory, had absorbed again the component analysis achievement of Modern Pharmaceutical Chemistry, had embodied generation novel composing prescription---the health care new product of the combination of Chinese and Western medicine.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
An antifatigue capsule, comprises the raw material of following mass distribution ratio: 540 parts of Folium Hippophae, 200 parts of Radix Rhodiolaes, 150 parts of Radix Polygoni Multiflori Preparatas, 100 parts of Fructus Corni, 80 parts of the Radixs Astragali, 55 parts of the Cortexs Eucommiae, 56 parts of Herba Epimedii, 50 parts of Cortex Moutans, 36 parts of Radix Ginsengs, 28 parts of calcium gluconate.
Be prepared as follows:
9 kinds of herbal raw material decoction pieces of described mass distribution ratio, through roguing, dust removal, pulverizing, mixing, are adopted to 80% edible ethanol material in mass ratio by mixed material: solution=1:20 soaks 1h, then, under temperature 60 C, extracts continuously 2h; By extracting solution after filtration, concentrated, the dry herbal raw material extract that obtains, described herbal raw material extract is mixed homogeneously with described calcium gluconate powder by quality proportioning, through granulating, be dried, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Embodiment 2
An antifatigue capsule, comprises the raw material of following mass distribution ratio: 550 parts of Folium Hippophae, 190 parts of Radix Rhodiolaes, 140 parts of Radix Polygoni Multiflori Preparatas, 90 parts of Fructus Corni, 75 parts of the Radixs Astragali, 60 parts of the Cortexs Eucommiae, 60 parts of Herba Epimedii, 60 parts of Cortex Moutans, 40 parts of Radix Ginsengs, 30 parts of calcium gluconate.
Be prepared as follows:
9 kinds of herbal raw material decoction pieces of described mass distribution ratio, through roguing, dust removal, pulverizing, mixing, are adopted to 80% edible ethanol material in mass ratio by mixed material: solution=1:15 soaks 1.2h, then, under temperature 60 C, extracts continuously 3h; By extracting solution after filtration, cryoconcentration, lyophilization obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Embodiment 3
An antifatigue capsule, comprises the raw material of following mass distribution ratio: 520 parts of Folium Hippophae, 185 parts of Radix Rhodiolaes, 100 parts of Radix Polygoni Multiflori Preparatas, 80 parts of Fructus Corni, 70 parts of the Radixs Astragali, 50 parts of the Cortexs Eucommiae, 50 parts of Herba Epimedii, 45 parts of Cortex Moutans, 33 parts of Radix Ginsengs, 25 parts of calcium gluconate.
Be prepared as follows:
By 9 kinds of herbal raw material decoction pieces of described mass distribution ratio through roguing, dust removal, pulverizing, mixing, mixed material is adopted to 80% edible ethanol material in mass ratio: solution=1:25 soaks 1.5h, then load 120 revs/min of ultrasound wave, mechanical agitation, the air compressor machine airflow stirring of 3kw power, under temperature 60 C, extract continuously 4h; Extracting solution is filtered through duplex, vacuum concentration to quality than solid content: solvent=1:3, then through frozen drying powdered, obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, through granulation, cold drying, sterilizing, capsule fill, obtain Folium Hippophae antifatigue capsule product.
Embodiment 4
An antifatigue capsule, comprises the raw material of following mass distribution ratio: 500 parts of Folium Hippophae, 180 parts of Radix Rhodiolaes, 120 parts of Radix Polygoni Multiflori Preparatas, 90 parts of Fructus Corni, 65 parts of the Radixs Astragali, 40 parts of the Cortexs Eucommiae, 55 parts of Herba Epimedii, 40 parts of Cortex Moutans, 30 parts of Radix Ginsengs, 20 parts of calcium gluconate.
Be prepared as follows:
By 9 kinds of herbal raw material decoction pieces of described mass distribution ratio through roguing, dust removal, pulverizing, mixing, mixed material is adopted to 80% edible ethanol material in mass ratio: solution=1:22 soaks 1h, then load 120 revs/min of ultrasound wave, mechanical agitation, the air compressor machine airflow stirring of 3kw power, under temperature 60 C, extract continuously 2h; Extracting solution is filtered through duplex, vacuum and low temperature is concentrated into quality than solid content: solvent=1:2, then through frozen drying powdered, obtain herbal raw material extract, described herbal raw material extract is mixed homogeneously with described calcium gluconate, through granulation, cold drying, sterilizing, capsule fill, obtain Folium Hippophae antifatigue capsule product.
Embodiment 5
An antifatigue capsule, comprises the raw material of following weight distribution ratio:
520 parts of Folium Hippophae extracts, 200 parts of Radix Rhodiolae extracts, 120 parts of Radix Polygoni Multiflori Preparata extracts, 90 parts of Fructus Corni extracts, 70 parts of Radix Astragali extracts, 50 parts of Cortex Eucommiae extract, 56 parts of Herba Epimedii extracts, 45 parts of Cortex Moutan extracts, 30 parts of Radix Ginseng extracts, 25 parts of calcium gluconate.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, the material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:15 soaks 1h, then, at 55 ℃ of temperature, extracts continuously 4h; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Embodiment 6
An antifatigue capsule, comprises the raw material of following weight distribution ratio:
535 parts of Folium Hippophae extracts, 190 parts of Radix Rhodiolae extracts, 130 parts of Radix Polygoni Multiflori Preparata extracts, 80 parts of Fructus Corni extracts, 60 parts of Radix Astragali extracts, 55 parts of Cortex Eucommiae extract, 55 parts of Herba Epimedii extracts, 60 parts of Cortex Moutan extracts, 40 parts of Radix Ginseng extracts, 20 parts of calcium gluconate.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, the material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:25 soaks 1.5h, then, under temperature 50 C, extracts continuously 3h; Extracting solution is filtered through duplex, and vacuum concentration than solid content: solvent=1:3, then through frozen drying powdered, obtains herbal raw material extract to quality; Described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Embodiment 7
An antifatigue capsule, comprises the raw material of following weight distribution ratio:
500 parts of Folium Hippophae extracts, 180 parts of Radix Rhodiolae extracts, 100 parts of Radix Polygoni Multiflori Preparata extracts, 85 parts of Fructus Corni extracts, 65 parts of Radix Astragali extracts, 45 parts of Cortex Eucommiae extract, 50 parts of Herba Epimedii extracts, 50 parts of Cortex Moutan extracts, 35 parts of Radix Ginseng extracts, 30 parts of calcium gluconate.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, the material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:22 soaks 1.2h, then, under temperature 60 C, extracts continuously 2.5h; Extracting solution is filtered through duplex, and vacuum and low temperature is concentrated into quality than solid content: solvent=1:2, then through frozen drying powdered, obtains herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Embodiment 8
An antifatigue capsule, comprises the raw material of following weight distribution ratio:
550 parts of Folium Hippophae extracts, 195 parts of Radix Rhodiolae extracts, 150 parts of Radix Polygoni Multiflori Preparata extracts, 100 parts of Fructus Corni extracts, 80 parts of Radix Astragali extracts, 60 parts of Cortex Eucommiae extract, 60 parts of Herba Epimedii extracts, 40 parts of Cortex Moutan extracts, 35 parts of Radix Ginseng extracts, 25 parts of calcium gluconate.
Be prepared as follows:
Successively by described 9 kinds of herbal raw material decoction pieces through roguing, dust removal, pulverizing, the material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:20 soaks 1h, then, at 65 ℃ of temperature, extracts continuously 2h; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
Food clothes example
1, Mr. Liu: 46 years old, Language Teacher.
Over nearly 3 years, normal sense without because of fatigue, on more tired after class, after rest, slightly take a turn for the better, often have a dream evening, drowsy, and it is tired out that often feel energy daytime, the aching and limp discomfort of extremity, be afraid of that stair climbing easily breathes, be afraid of to walk, walked howly aching and limp with regard to both legs, and sexual disorder goes down.In hospital, can not check reason, electrocardiogram, electroencephalogram, hepatic and renal function is all normal, and patient's appearance looks that what does not have is yet obviously abnormal, within several years, seeks medical advice without door, and heart is very painful.Also take some nutritional supplements, but be difficult to obvious onset.
Take 3 ~ 4 of Jin Kehai antifatigue capsule every days, first feel that dream in evening is few after first quarter moon, sleep takes a favorable turn, and extremities aching pain greatly alleviates.After 30 days, 2 class get off almost not feel to have feeling of fatigue, evening majority can sleep one complete, climb 6th floors stair and also do not feel that nervous lower limb is soft, and be obviously improved the effect of sexual function.So far he taken 3 months continuously without because of feeling of fatigue substantially disappear.
2, Mr. Wang: 67Sui， retired employees.
Long-term smoking, wrap every day one; Noon every day, dinner each 2 Two of drinking that drink with snacks, happiness food meat, obesity.Through examination in hospital, suffer from mild asthma disease, hypertension, hyperlipidemia, fatty liver, diabetes, chronic gastritis.Within nearly 2 years, feel weak, dizziness, drowsiness, lower limb is aching and limp, and rest can not alleviate, and does not do things also tired, is also difficult to alleviate after sleep, the urine 3 ~ 4 times of getting up every night.
Take 3 ~ 4 of Jin Kehai antifatigue capsule every days, and the cigarette amount 1/3 that is situated between to fall.After first quarter moon, first feel that evening, urine reduced to 2 ~ 3 times, dizziness alleviates, drowsiness minimizing, and lower limb is aching and limp to be alleviated, and cough alleviates.Take after 30 days, evening, urine reduced to 2 times, there is no dizziness, had not had drowsinessly, and basic lower limb is seldom aching and limp, and cough further alleviates, and spirit is improved greatly.
3, Mr. Hou: 71 years old, retired cadre.
Like for a long time vegetarian diet, appetite is little, physical weakness,, often there is constipation in easy catching a cold, write on computers article or play games 3 ~ 4 hours every days, time has been grown VAOU reduction, blurred vision, fear of cold, weakness of the lower extremities, stand up lower limb with regard to ache, and especially shank, can not go on a journey, get up every night urine 4 ~ 5 times, sleep quality is very poor.Through examination in hospital, suffer from severe diabetes mellitus, suffer from the degeneration of old yellow class, prostatitis, varicosis.
Take 3 ~ 4 of Jin Kehai antifatigue capsule every days, first feel that evening, urine number of times reduced to 3 ~ 4 times after first quarter moon, sleep quality improves, and fear of cold alleviates, and blurred vision makes moderate progress.Take after 30 days, evening, urine reduced to 2 times, and majority can have a sweet sleep, and worked on computers and within 3 ~ 4 hours, also can not help too tired, and blurred vision is greatly improved, and physical energy also has greatly increase, and lower limb ache also alleviates, and can slowly walk 20 minutes roads, does not substantially feel tired.
4, CHENNU scholar: 34 years old, civil servant.
The long-term office that sits, happiness is eaten omnivorous, does not like motion, and body constitution is fat, and operating pressure is large, when many, also will work overtime.Often think that weak, coolness of extremities, happiness heat is afraid of cold, dry mouth and throat, god is tired to breathe hard, dizziness, poor sleeping quality, dysphoria with feverish sensation in the chest palms and soles, menoxenia, menostaxis, lusterless complexion, sexual disorder, can't help doing urine, the empty hyperhidrosis of body, waist lower limb feels like jelly.Through examination in hospital, suffer from mild hypertension, hyperlipidemia, blood viscosity is high, cyclomastopathy, leukocyte count is greater than 400,000, has inflammation.
Take 3 ~ 4 of Jin Kehai antifatigue capsule every days, first feel the dry mouth and throat minimizing of drinking water after first quarter moon, extremity start warm, and hyperhidrosis reduces, and dizziness alleviates.Take after 30 days, the of that month eumenorrhea, sexual function also has clear improvement, and has had on foot strength, and sleep quality improves greatly, does not even go a toilet a whole night.
Experimental example
Of the present invention in order to evaluate, the present invention has carried out the mice test of pesticide effectiveness and toxicity test and crowd and has eaten clothes test.
1, mouse anti-reflecting fatigue test
Kunming kind SPF level mice, male and female half and half for experiment.Anti-fatigue test method is that mice is divided into basic, normal, high 3 dosage groups and 1 matched group, 20 every group at random.3 dosage groups are respectively with the extract gavage of capsule of the present invention, and dosage is respectively 2.0,4.0,6.0gkg
-1d
-1; Matched group is with 6.0mLkg
-1d
-1normal saline gavage, 30d is all raised in each group experiment continuously, and between culture period, mice can freely ingest and drink water.After 30d gavage 1h, carry out swimming with a load attached to the body experiment.Right side of mice buttocks bundle is added to the lead fuse wire being equivalent to from body quality 5%, then put into 30 ± 1 ℃, the tank went swimming of the depth of water 400 mm, with mouse head, do not have the following 8s of upstream face no longer to float, be judged to be fatigue, each group fatigue time of record.
2, mice serum carbamide is measured
Get 40 of mices, be divided into 4 groups, after last administration 30 min, at water went swimming 90 min of 30 ℃, the 0.5mL of angular vein blood sampling immediately after 60 min that have a rest.3000 rmin after 4 ℃ of standing 3 h
-1centrifugal 15min, gets serum, with automatic clinical chemistry analyzer, measures serum urea value.
3, blood Plasma lactate
After mice last administration 30 min, mice is not born a heavy burden to be placed in water temperature be 30 ℃, the depth of water is swimming 30 min in the swimming trunk of 35 cm; Have a rest after 20 min, angular vein blood sampling.The centrifugal 15 min separation of serum of 2500rmin, adopt spectrophotometer method to measure Serum lactic acid content.
The result of the test of above-mentioned test 1,2,3 is listed in to table 1.
Note: with negative control group comparison, P < 0.05 ± 1.1
Table 1 data is seen, the present invention and matched group comparison, and middle and high dosage group swimming time obviously extends, significant difference (P<0.01), low dose group and matched group difference is (P>0.01) not significantly.Impact on serum urea nitrogen, Serum lactic acid content, middle and high dosage group and matched group comparison, be all starkly lower than matched group (P < 0.01).Tired topmost performance is that exercise tolerance declines.Experimental result shows, Folium Hippophae antifatigue capsule of the present invention has the significant prolongation mice burden swimming time.Blood urea nitrogen is decomposed to form by body internal protein, and body internal protein oxidation energy supply degree is higher, and blood urea nitrogen content is just higher, and body is poorer to motion fitness, to be easier tired, this experimental result blood urea nitrogen content low showing, the enhancing of mouse anti-reflecting fatigue ability.Reduce serum urea nitrogen and Serum lactic acid content, indirectly reflect that Folium Hippophae antifatigue capsule of the present invention has obvious antifatigue effect.
4, crowd eats clothes test
Blindly select 18 people, male 12 people, female 6 people, take 4 of products of the present invention (quite pure extract mixtures 2g) for each person every day, 30 days time, inquire into the effect of Folium Hippophae antifatigue capsule enhancing body endurance of the present invention and resisting fatigue.After taking continuously 1 month, adopt questionnaire survey ginseng anthropophagy person's endurance and anti-fatigue ability to improve situation, result shows: that takes Folium Hippophae antifatigue capsule successful of the present invention accounts for 67.3%, what make moderate progress accounts for 25.6%, effective percentage is 92.9%, invalid accounts for 7.1%, can significantly improve food with matched group comparison and take personnel's endurance and anti-fatigue ability, difference has statistical significance (P < 0.01); And showing that Folium Hippophae antifatigue capsule of the present invention has refreshes oneself, alleviates prostatitis, raising property vigor, regulates the effects such as asthenopia, sleep be stable.
5, mice polarity toxicity test
Select 40 of Kunming kind 19g ~ 21g healthy mices, male and female half and half, adopt group feeding, all by 0.4mg.kg
-1.d
-1gavage of extract, observes 7d, has no any poisoning manifestations and death.Show that the present invention is to the oral LD of mice
50higher than 0.4mg.kg
-1.d
-1 ,belong to nontoxic level.By human body standard 70kg, LD
50>28g.d
-1, belong to nontoxic level health product.
The present invention can summarize with other the concrete form without prejudice to spirit of the present invention or principal character.Therefore, no matter from that, above-mentioned embodiment of the present invention all can only think explanation of the present invention can not limit invention, claims have been pointed out scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore,, in the implication suitable with claims of the present invention and any variation in scope, all should think to be included in the scope of claims.
Claims (7)
1. a Folium Hippophae antifatigue capsule, is characterized in that comprising the raw material of following mass distribution ratio: Folium Hippophae 500-550 part, Radix Rhodiolae 180-200 part, Radix Polygoni Multiflori Preparata 100-150 part, Fructus Corni 80-100 part, Radix Astragali 60-80 part, Cortex Eucommiae 40-60 part, Herba Epimedii 50-60 part, Cortex Moutan 40-60 part, Radix Ginseng 30-40 part, calcium gluconate 20-30 part.
2. a kind of Folium Hippophae antifatigue capsule according to claim 1, it is characterized in that in described raw material except calcium gluconate, other herbal raw material Folium Hippophae, Radix Rhodiolae, Radix Polygoni Multiflori Preparata, Fructus Corni, the Radix Astragali, the Cortex Eucommiae, Herba Epimedii, Cortex Moutan, Radix Ginseng all adopt extract, and by extract weight, that is:
Folium Hippophae extract 500-550 part, Radix Rhodiolae extract 180-200 part, Radix Polygoni Multiflori Preparata extract 100-150 part, Fructus Corni extract 80-100 part, Radix Astragali extract 60-80 part, Cortex Eucommiae extract 40-60 part, Herba Epimedii extract 50-60 part, Cortex Moutan extract 40-60 part, Radix Ginseng extract 30-40 part, calcium gluconate 20-30 part.
3. the preparation method of a kind of Folium Hippophae antifatigue capsule according to claim 1, it is characterized in that comprising the following steps: by 9 kinds of herbal raw materials of described mass distribution ratio through roguing, dust removal, pulverizing, mixing, mixed material is adopted to 80% edible ethanol material in mass ratio: solution=1:15-25 soaks 1h, then under temperature 60 C, extract continuously 2h; By extracting solution after filtration, concentrated, cold drying obtains herbal raw material extract; Described herbal raw material extract is mixed homogeneously with described calcium gluconate, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
4. according to the preparation method of a kind of Folium Hippophae antifatigue capsule described in claim 2, it is characterized in that comprising the following steps: successively by described 9 kinds of herbal raw materials through roguing, dust removal, pulverizing, material after pulverizing is adopted to 80% edible ethanol material in mass ratio: solvent=1:15-25 soaks 1-1.5h, then at temperature 50-65 ℃, extract continuously 2-4h; By extracting solution after filtration, concentrated, dry, obtain herbal raw material extract; Described Chinese herbal medicine extract and calcium gluconate are pressed to mass distribution ratio mix homogeneously, through granulating, dry, sterilizing, capsule fill obtain Folium Hippophae antifatigue capsule product.
5. according to the preparation method of a kind of Folium Hippophae antifatigue capsule described in claim 3 or 4, it is characterized in that: the condition of described continuous extraction is for loading 120 revs/min of ultrasound wave, mechanical agitation, the air compressor machine airflow stirring of 3kw power.
6. according to the preparation method of a kind of Folium Hippophae antifatigue capsule described in claim 3 or 4, it is characterized in that: described extracting solution adopts duplex to filter.
7. according to the preparation method of a kind of Folium Hippophae antifatigue capsule described in claim 3 or 4, it is characterized in that: the extracting solution after described filtration, through falling film evaporator, be concentrated into quality than solid content: solvent=1:2-3, then through frozen drying powdered, obtain herbal raw material extract powder.
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| CN105011307A (en) * | 2015-07-05 | 2015-11-04 | 青岛浩大海洋保健食品有限公司 | Aging preventing abalone and sea cucumber health-care beverage |
| CN108567811A (en) * | 2018-07-04 | 2018-09-25 | 神威药业集团有限公司 | It is a kind of that there is antifatigue, immunoloregulation function composition and its preparation method and application |
| CN108567811B (en) * | 2018-07-04 | 2021-07-20 | 神威药业集团有限公司 | Composition with anti-fatigue and immunoregulation functions and preparation method and application thereof |
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| CN103520302B (en) | 2015-06-24 |
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