CN102871132A - Health care soft capsule for strengthening immunity and preparation method thereof - Google Patents
Health care soft capsule for strengthening immunity and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a health care soft capsule for strengthening immunity and a preparation method of the health care soft capsule. The health care soft capsule comprises a capsule material which is made up of the following raw materials in percentage by weight: 30 to 40% of propolis extract, 20 to 30% of fish oil and 30 to 50% of purple perilla seed oil. A propolis soft capsule health care food is prepared by mixing the raw materials to obtain the capsule material, and then carrying out the processes of pelleting, drying, pillet washing, selecting and split charging. According to the invention, the health care soft capsule is composed of a propolis supercritical CO2 extract, the fish oil and the purple perilla seed oil. A supercritical CO2 extraction technology is utilized, the effective components of the propolis are concentrated and preserved, and the harmful substances such as lead and sensibilisins are removed; and the soft capsule is better for the human body to absorb due to the fact that the soft capsule is obtained by dissolving the purple perilla seed oil as a dispersing carrier into the fish oil.
Description
Technical field
The present invention relates to a kind of health-caring capsule and preparation method thereof, particularly a kind of health-caring capsule of strengthening immunity and preparation method thereof that helps.
Background technology
Along with being growing more intense of social development, competition, rhythm of life is constantly accelerated, the pressure that people bear is increasing, people's health also descends thereupon, can almost everyone know, strengthen immunity to healthy and helpful, but what is immunity on earth? if a person is poor, liable to illness, people will say that his resistance is poor; Resistance is said immunity medically namely, and it is a kind of ability that the human immune system carries out self-protection, and one of main effect refers to that body resistance bacterium or virus wait the ability of infection.
The crowd of hypoimmunity is exactly the suitable crowd who strengthens immunity.If common people have following phenomenon, all belong to hypoimmunity: 1, feel easily tired, but can not check organic disease; 2, often catch a cold; 3, wound infects easily, and healing is slow; 4, stomach is poor.Here mainly refer to eat a little to such an extent that improperly just suffer from vomiting and diarrhoea.
Be in the rehabilitation phase and in, the crowd of old age bracket, cause easily these nutrient loss increase and metabolic disorders; And external environment changes, work and study pressure increases, and also can cause nutrient to lack or disequilibrium.Not enough or supply with when unbalanced when raw material supply, body can't in time synthesize disease-resistance substance formation defense system, and germ just is easy to invade human body, and health is constituted a threat to.Therefore, improve immunity of organisms, the opposing external environment changes the impact that human body is brought, calmly and healthily life.Also just because of this, having the health food that increases immunity arises at the historic moment.The purpose of health food research of the present invention just is actual health status and the demand according to vast hypoimmunity crowd, utilizes new scientific achievement, and the product that a kind of functional components is clear and definite and have increase immunity effect is provided.
Modern immunology thinks that immunity is body identification and removes nonself macromolecular substances, and the physiological reaction of holder internal and external equilibrium, and namely body is to the process of the identification of " non-oneself " material, eliminating, elimination.Over nearly 20 years, modern immunology has had rapidly development in various aspects such as theory and technologies, but in the research and utilization of medicine, more and more difficult.And traditional natural Chinese medicinal herb has kept natural structure and activity, has the advantages such as pleiotropism, bidirectional modulation and adaptogen.Many enriching yin, enrich blood, beneficial gas, supporing yang Chinese herb medicine all can improve the immunologic function of body, to the humoral immunity of body, cellular immunity, and non-specific immune function certain facilitation is all arranged.
Summary of the invention
The purpose of this invention is to provide a kind of health-caring capsule that strengthens immunity and preparation method thereof, the present invention is with the propolis supercritical CO
2Extract, fish oil, perilla oil form, and utilize the fluidization supercritical CO
2Abstraction technique, concentrated various active ingredients of having saved propolis from damage, and removed harmful substance and the allergins such as plumbous, and take perilla oil as dispersible carrier, be dissolved in and make soft capsule in the fish oil, be more conducive to be absorbed by the body and the spirited performance that acts on of propolis; In addition, preparation method provided by the invention, easy to operate.
A kind of health care soft capsule that strengthens immunity comprises the capsule material, and wherein, described capsule material consists of the following composition, and counts by weight percentage: propolis extract 30-40%, fish oil 20-30%, Purple Perilla Seed Oil 30-50%.
The health care soft capsule of above-mentioned enhancing immunity, wherein, described capsule material optimum ratio is counted by weight percentage: propolis extract 30%, fish oil 20%, Purple Perilla Seed Oil 50%.
The health care soft capsule of above-mentioned enhancing immunity, wherein, described propolis extract is supercritical CO
2Extraction makes.
The preparation method of the health care soft capsule of above-mentioned enhancing immunity comprises the steps:
A, preparation capsule material are heated to 50 ℃ of insulations after fish oil sieved; Perilla oil is heated to 55～60 ℃, and after adding propolis extract was continuously stirring to fully dissolving, mixing speed 25-30rpm/min added in the fish oil, and stirred 10 minutes, open vacuum, carry out de-bubbled, vacuum is-0.09-0.094Mpa, places under 45～50 ℃ of temperature, and is for subsequent use;
B. change glue
In joining glue pot, add purified water, add thermal agitation, add simultaneously glycerine, sorbierite, after the solution clarification, add gelatin and add thermal agitation, through 30～70 minutes, temperature makes gelatin dissolve the formation glue in the time of 80～90 ℃ ,-0.07～-take out the liquid Air that removes photoresist under the 0.09MPa vacuum, remove vacuum, under 80～90 ℃ of temperature with 80 order thin,tough silk yarns filtration glue in; Gelatin: glycerine: sorbierite: water=5: 1:1: 5;
C pelleting and typing
18～24 ℃ of temperature, under the condition of relative humidity 20%～65%, carry out pelleting; Decide again;
D. dry, choose ball, wipe ball
With stereotyped capsule and pill drying 6～10 hours, the hothouse temperature was 24～29 ℃, relative humidity 15～40%,
Predrying good soft capsule is chosen flat ball, leakage of oil ball, steam bubble ball, wiped ball with soaking the clear ball cloth of wiping of 95% wine, get final product.
The preparation method of the health care soft capsule of above-mentioned enhancing immunity, wherein, mixing speed is 25-30rpm/min in the described steps A.
The preparation method of the health care soft capsule of above-mentioned enhancing immunity, wherein, vacuum is-0.09-0.094Mpa when carrying out de-bubbled in the described steps A.
Propolis
Propolis resin or natural gum that to be honeybee gather from the young shoot of plant and the broken injury of trunk are sneaked into the formed colloidal solid materials with aromatic odor and stickiness such as honeybee palate glandular secretion thing and beeswax.Propolis is rich in Flavonoid substances with health role, has terpenoid substance and and a large amount of minerals and vitamins etc. of antitumaous effect.Modern study shows that propolis can strengthen immunologic function, is natural immunopotentiator.Hu Yixiu etc. have carried out the experimental study of Beijing Propolis on the immune function of mice impact, the result shows, propolis can obviously improve the ability of the delayed allergy of mouse, improve mouse antibodies cellulation number, HD50 value, obviously strengthen mouse monokaryon-macrophage carbon and clean up ability, obviously improve the NK cells in mice activity.The proof propolis has the effect that strengthens immunity.Shao Yan etc. are in order to observe propolis to the impact of mouse immune regulatory function, utilize mtt assay, ear swelling method, Jerne improvement slide method, Hemagglutination Method, half intracorporal method, determination of lactate dehydrogenase method to test, the result shows that propolis extract has the mouse cell immunologic function of enhancing and humoral immune function.Propolis extract also has the effect that strengthens macrophage phagocytosis of mice and NK cells in mice activity.In addition, carried out the experimental study of propolis on the immune function of mice impact in Xiao Hong etc., Li Shuhua etc. have carried out the impact of propolis on immunologic hypofunction model mouse cellular immune function, and the result shows that all propolis has the effect that strengthens immunity.
The propolis supercritical CO
2Extract is that propolis extracts the mass efficient composition in the propolis by fluidization supercritical CO 2 fluid extraction technology, both guaranteed the existence and activity of various active ingredients in the propolis, greatly reduce again the residual of propolis poisonous and harmful substance, so that the bee glue product better effects if.Studies show that: compare the propolis supercritical CO with the propolis that adopts alcoholic extract
2The antitumaous effect of extract is eager to excel 10 times, and anti-inflammatory effect is eager to excel 20-40 doubly, and anti-allergic effects is eager to excel 50-100 doubly.
Fish oil
Be a kind of natural health product that refining forms from the fat of marine fishes, be rich in omega-3 unsaturated fatty acid, especially DHA and EPA two large class aliphatic acid all belong to polyunsaturated fatty acid.Because this aliphatic acid is that human body can't synthesize, and must absorb from the external world.Fish oil is the optimum food that human body replenishes DHA and EPA.The effect of DHA mainly contains and reduces cholesterol and triglycerides; Reduce Platelet, strengthen ED, prevent thrombosis; The treatment eyes are dry and astringent, vision protection; Improve memory, improve learning ability; The prevention of cancer and auxiliary curing.The effect of EPA mainly contains and reduces cholesterol and triglycerides; Reduce Platelet, strengthen ED, prevent thrombosis.
Perilla oil
Be a kind of natural oil of high degree of unsaturation, contained Main Ingredients and Appearance is the α-type leukotrienes, and content is that this content of fatty acid is the highest in all crude vegetals of finding at present up to 50%-70%.In addition, oleic acid and linoleic content also about 30%, also have other palmitic acid of about 5%, as seen are a kind of natural plant resources with very high physiological activity.The main effect of perilla oil has: reducing blood lipid, and hypotensive, anti-allergic effects falls in antithrombotic, and is anticancer, prevents and improves cardiovascular and cerebrovascular disease; Delay senility, remove free radical, brain tonic, short intelligence improves thinking ability.
Modern studies show that the immunological enhancement of propolis is inseparable with its complicated chemical composition.A large amount of experiment showed, many enzymes, alcohols, lipid, acids in the propolis have widely effect to the immune system of body.The present invention is with the propolis supercritical CO
2Extract is primary raw material, with fish oil, perilla oil compatibility together, the function that strengthens immunity of organisms is arranged, reached the possibility that quantizes compatibility and strengthen effect, utilize simultaneously the anti-allergic effects that has that perilla oil has, can weaken propolis product to fraction crowd's bad allergic reaction.Every kind of raw material all has no side effect, and has the health care that strengthens immunity through the animal experiment proof.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment.
The water of the purified water hyoscine that to be drinking water make through the way of distillation, ion-exchange, hyperfiltration or other suitable methods does not contain any additive.
Embodiment one
A kind of health care soft capsule that strengthens immunity comprises the capsule material, and described capsule material consists of the following composition, and counts by weight percentage: propolis extract 30%, fish oil 20%, Purple Perilla Seed Oil 50%, propolis supercritical CO
2Extract is to use the fluidization supercritical CO
2Active ingredient in the propolis that fluid extraction technology extracts.Follow these steps to preparation:
A. prepare the capsule material
Fish oil 20kg is sieved in the rear adding emulsification pot, heat to 50 ℃ of insulations; Perilla oil 50kg is heated to 55～60 ℃, adds the propolis supercritical CO
2Extract 30kg adds in the emulsification pot after being stirred to fully dissolving, stirs 10 minutes, opens vacuum, carries out de-bubbled.While hot discharging is in heat-preserving container, and holding temperature is 45～50 ℃, and it is for subsequent use to get capsule 's content.
B. change glue
In gelatin: glycerine: sorbierite: water=5: 1:1: 5 ratio is prepared burden, in joining glue pot, add purified water 24.5kg, add and add glycerine 4.9kg under the thermal agitation, sorbierite 4.9kg, after the solution clarification, add gelatin 24.5kg and add thermal agitation, through 50 minutes, temperature is in the time of 80～90 ℃, make gelatin fully dissolve (i.e. the lower gelatin of range estimation all dissolves without particle),-0.07～-the liquid Air that removes photoresist taken out under the 0.09MPa vacuum, remove vacuum, temperature is filtered in the glue bucket (as the glue that leaches bubble is arranged, can prolong the pumpdown time) with 80 order thin,tough silk yarns in the time of 80～90 ℃;
C pelleting and typing
Keep 18～24 ℃ of room temperatures, relative humidity 20%～65% between pelleting; Regulate sprinkler body temperature and rotating speed, the sprinkler body temperature is 35-50 ℃ and rotating speed 2.2rpm/min, carries out pelleting (0.4g/ grain); The capsule and pill that presses is finalized the design in rotating cage.
D. dry, choose ball, wipe ball
With stereotyped capsule and pill drying 6～10 hours, the hothouse temperature was 24～29 ℃, and relative humidity 15～40% is chosen flat ball, leakage of oil ball, steam bubble ball with predrying good soft capsule, wiped ball with soaking the clear ball cloth of wiping of 95% wine.
Soft capsule net content of the present invention is the 0.4g/ grain, dose: every day 2 times, each 2.
Embodiment two
A kind of health care soft capsule that strengthens immunity comprises the capsule material, and wherein, described capsule material consists of the following composition, and counts by weight percentage: propolis extract 35%, fish oil 25%, Purple Perilla Seed Oil 40%.
A. prepare the capsule material
Fish oil 25kg is sieved in the rear adding emulsification pot, heat to 50 ℃ of insulations; Perilla oil 40kg is heated to 55～60 ℃, adds the propolis supercritical CO
2Extract 35kg adds in the emulsification pot after being stirred to fully dissolving, stirs 10 minutes, opens vacuum, carries out de-bubbled.While hot discharging is in heat-preserving container, and holding temperature is 45～50 ℃, and it is for subsequent use to get capsule 's content.
B. change glue
In gelatin: glycerine: sorbierite: water=5: 1:1: 5 ratio is prepared burden, in joining glue pot, add purified water 24.5kg, add and add glycerine 4.9kg under the thermal agitation, sorbierite 4.9kg, after the solution clarification, add gelatin 24.5kg and add thermal agitation, through 50 minutes, temperature is in the time of 80～90 ℃, make gelatin fully dissolve (i.e. the lower gelatin of range estimation all dissolves without particle),-0.07～-the liquid Air that removes photoresist taken out under the 0.09MPa vacuum, remove vacuum, temperature is filtered in the glue bucket (as the glue that leaches bubble is arranged, can prolong the pumpdown time) with 80 order thin,tough silk yarns in the time of 80～90 ℃;
C pelleting and typing
Keep 18～24 ℃ of room temperatures, relative humidity 20%～65% between pelleting; Regulate sprinkler body temperature and rotating speed, the sprinkler body temperature is that 35-50 ℃ and rotating speed 2.2rpm/min carry out pelleting (0.4g/ grain); The capsule and pill that presses is finalized the design in rotating cage.
D. dry, choose ball, wipe ball
With stereotyped capsule and pill drying 6～10 hours, the hothouse temperature was 24～29 ℃, and relative humidity 15～40% is chosen flat ball, leakage of oil ball, steam bubble ball with predrying good soft capsule, wiped ball with soaking the clear ball cloth of wiping of 95% wine.
Soft capsule net content of the present invention is the 0.4g/ grain, dose: every day 2 times, each 2.
Embodiment three
A kind of health care soft capsule that strengthens immunity comprises the capsule material, and described capsule material consists of the following composition, and counts by weight percentage: propolis extract 40%, fish oil 30%, Purple Perilla Seed Oil 30%.Follow these steps to preparation:
A. prepare the capsule material
Fish oil 30kg is sieved in the rear adding emulsification pot, heat to 50 ℃ of insulations; Perilla oil 30kg is heated to 55～60 ℃, adds the propolis supercritical CO
2Extract 40kg adds in the emulsification pot after being stirred to fully dissolving, stirs 10 minutes, opens vacuum, carries out de-bubbled.While hot discharging is in heat-preserving container, and holding temperature is 45～50 ℃, and it is for subsequent use to get capsule 's content.
B. change glue
In gelatin: glycerine: sorbierite: water=5: 1:1: 5 ratio is prepared burden, in joining glue pot, add purified water 24.5kg, add and add glycerine 4.9kg under the thermal agitation, sorbierite 4.9kg, after the solution clarification, add gelatin 24.5kg and add thermal agitation, through 50 minutes, temperature is in the time of 80～90 ℃, make gelatin fully dissolve (i.e. the lower gelatin of range estimation all dissolves without particle),-0.07～-the liquid Air that removes photoresist taken out under the 0.09MPa vacuum, remove vacuum, temperature is filtered in the glue bucket (as the glue that leaches bubble is arranged, can prolong the pumpdown time) with 80 order thin,tough silk yarns in the time of 80～90 ℃;
C pelleting and typing
Keep 18～24 ℃ of room temperatures, relative humidity 20%～65% between pelleting; Regulate sprinkler body temperature and rotating speed, the sprinkler body temperature is 35-50 ℃ and rotating speed 2.2rpm/min, carries out pelleting (0.4g/ grain); The capsule and pill that presses is finalized the design in rotating cage.
D. dry, choose ball, wipe ball
With stereotyped capsule and pill drying 6～10 hours, the hothouse temperature was 24～29 ℃, and relative humidity 15～40% is chosen flat ball, leakage of oil ball, steam bubble ball with predrying good soft capsule, wiped ball with soaking the clear ball cloth of wiping of 95% wine.
Soft capsule net content of the present invention is the 0.4g/ grain, dose: every day 2 times, each 2.
Help to strengthen the function test of immunity:
1.1 animal used as test
1.1.1 source: Shanghai Slac Experimental Animal Co., Ltd..
Kunming mouse, the cleaning level;
The animal quality certification number: SCXK(Shanghai) 2003-0003;
Occupancy permit number: 2002-0130 SYXK(Soviet Union);
Body weight: 18-22 gram.
1.1.2 dosage design
Given the test agent is the propolis supercritical CO
2The mixing light yellow liquid of extract, fish oil and Purple Perilla Seed Oil.Be divided into basic, normal, high three dosage groups, get respectively 0.1g, 0.2g, 0.4g, be in harmonious proportion to 20ml with common edible salad oil.
1.2 experimental technique and result
1.2.1 body weight, thymus gland/body weight ratio and spleen/body weight ratio
Mouse is divided into negative control group and basic, normal, high three dosage groups at random, 10 every group, designs according to dosage, the gavage volume that gives tested material is 20ml/kgBw, once a day, feeds continuously 30 days, all animals used as test are edible full nutrition mixed feed all, the drinking-water of freely ingesting.
Body weight, thymus gland/body weight ratio and spleen/body weight ratio
The result shows that each dosage group is compared with negative control group, no significant difference (P＞0.5).
1.2.2 the mouse spleen lymphocyte conversion test (mtt assay) that ConA induces:
The SPL conversion test
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, sample high dose group and negative control group comparing difference significance (P＜0.05).
1.2.3 dinitrofluorobenzene inducing mouse delayed allergy test (ear swelling method):
The delayed allergy test
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, dosage and high dose group and negative control group comparing difference significance (P＜0.05) in the sample.
1.2.4 antibody-producting cell detects test (Jerne improves slide method):
Antibody-producting cell detects test
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, sample high dose group and negative control group comparing difference significance (P＜0.05).
1.2.5 the mensuration of serum hemolysin (Hemagglutination Method):
The mensuration of serum hemolysin
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, sample high dose group and negative control group comparing difference significance (P＜0.05).
1.2.6 mouse carbon clearance test:
The clearance test of mouse carbon
Each average of organizing phagocytic index is the trend that increases gradually, but through one-way analysis of variance, group difference has no remarkable meaning (P＞0.05).
3.2.7 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell test (half intracorporal method):
Peritoneal macrophage is engulfed the chicken red blood cell test
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, sample high dose group and negative control group comparing difference significance (P＜0.05).
1.2.8 NK cytoactive detection test (determination of lactate dehydrogenase method):
The test of NK cytoactive detection
* Dunnett ' s t check is with negative control group comparing difference significance (P＜0.05)
Through one-way analysis of variance, the result shows, sample high dose group and negative control group comparing difference significance (P＜0.05).
1.3 conclusion
After animal used as test was fed 30 days according to design dosage, every experimental result shows, can promote the carbon of the spleen lymphocyte proliferation of mouse and transformation and delayed allergy, raising mouse antibodies cellulation number and serum hemolysin, promotion mouse macrophage to clean up with the phagocytic activity of peritoneal macrophage, improve the NK cytoactive.Effective Raise cell immunocompetent and humoral immunity ability strengthen immunity of organisms.The propolis supercritical CO
2The compatibility thing of extract, fish oil and Purple Perilla Seed Oil has the function that strengthens immunity.
Claims (6)
1. a health care soft capsule that strengthens immunity comprises the capsule material, it is characterized in that, described capsule material consists of the following composition, and counts by weight percentage: propolis extract 30-40%, fish oil 20-30%, Purple Perilla Seed Oil 30-50%.
2. the health care soft capsule of enhancing immunity as claimed in claim 1 is characterized in that, described capsule material optimum ratio is counted by weight percentage: propolis extract 30%, fish oil 20%, Purple Perilla Seed Oil 50%.
3. the health care soft capsule of enhancing immunity as claimed in claim 1 or 2 is characterized in that, described propolis extract is supercritical CO
2Extraction makes.
4. strengthen as claimed in claim 1 the preparation method of the health care soft capsule of immunity, it is characterized in that, comprise the steps:
A, preparation capsule material are heated to 50 ℃ of insulations after fish oil sieved; Perilla oil is heated to 55～60 ℃, after adding propolis extract is stirred to fully dissolving, adds in the fish oil, and stirred 10 minutes, open vacuum, carry out de-bubbled, under 45～50 ℃ of temperature, place, for subsequent use;
B. change glue
In joining glue pot, add purified water, add thermal agitation, add simultaneously glycerine, sorbierite, after the solution clarification, add gelatin and add thermal agitation, through 30～70 minutes, temperature makes gelatin dissolve the formation glue in the time of 80～90 ℃ ,-0.07～-take out the liquid Air that removes photoresist under the 0.09MPa vacuum, remove vacuum, under 80～90 ℃ of temperature with 80 order thin,tough silk yarns filtration glue in; Gelatin: glycerine: sorbierite: water=5: 1:1: 5, by weight;
C pelleting and typing
18～24 ℃ of temperature, under the condition of relative humidity 20%～65%, carry out pelleting; Decide again;
D. dry, choose ball, wipe ball
With stereotyped capsule and pill drying 6～10 hours, the hothouse temperature was 24～29 ℃, relative humidity 15～40%,
Predrying good soft capsule is chosen flat ball, leakage of oil ball, steam bubble ball, is that 95% wine is wiped clearly ball cloth and wiped ball with soaking mass concentration percentage, gets final product.
5. strengthen as claimed in claim 4 the preparation method of the health care soft capsule of immunity, it is characterized in that, mixing speed is 25-30rpm/min in the described steps A.
6. such as the preparation method of the health care soft capsule of enhancing immunity as described in claim 4 or 5, it is characterized in that vacuum is-0.09-0.094Mpa when carrying out de-bubbled in the described steps A.
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| CN103190621A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Propolis soft capsule and preparation method thereof |
| CN103190618A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Gynostemma pentaphyllum-propolis composite soft capsule and preparation method thereof |
| CN103190619A (en) * | 2013-04-03 | 2013-07-10 | 上海春芝堂生物制品有限公司 | Fish oil and linseed oil soft capsules and preparation method thereof |
| CN103349289A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Preparation method of fish oil soft capsules |
| CN103637197A (en) * | 2013-12-03 | 2014-03-19 | 江苏江大源生态生物科技有限公司 | Propolis soft capsule and preparation method thereof |
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Cited By (5)
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Application publication date: 20130116 |