CN102228607B - Oral liquid for treating swine unknown high fever - Google Patents
Oral liquid for treating swine unknown high fever Download PDFInfo
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- CN102228607B CN102228607B CN201110178164.XA CN201110178164A CN102228607B CN 102228607 B CN102228607 B CN 102228607B CN 201110178164 A CN201110178164 A CN 201110178164A CN 102228607 B CN102228607 B CN 102228607B
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Abstract
The invention relates to oral liquid for treating swine unknown high fever and a preparation method thereof. The oral liquid comprises the following Chinese herbal medicines in part by weight: 100 to 200 parts of gypsum, 80 to 150 parts of common anemarrhena rhizome, 80 to 150 parts of liquoric root, 50 to 100 parts of golden thread, 80 to 150 parts of baical skullcap root, 80 to 150 parts of fructus gardeniae seed, 80 to 150 parts of phellodendron, 80 to 150 parts of indigowoad root and 100 to 200 parts of Mongolian dandelion herb, the Chinese herbal medicines are prepared according to a weight ratio and are decocted in water to form an aqueous solution agent. The oral liquid is mainly used for treating symptoms such as failure to abatement of high fever, thick and coarse coats, desuetude in appetite, depressed in spirits, rubefaction and cyanosis of skin of whole bodies, expiratory dyspnea, asthma, rhinorrhea, increase in the secretion of eyes and the like which are caused by accumulation of damp and heat, warm pathogen attacking lung, direct attack of pericardium and failure to abatement of asthenic fever and has the obvious treatment effect on growing and fattening pigs and sows; and the cure rate is more than 85 percent.
Description
Technical field
The invention belongs to treatment animal disease medicine, particularly relate to a kind of prepare taking Chinese herbal medicine as raw material be used for the treatment of oral liquid of unknown high fever of pigs and preparation method thereof.
Background technology
In recent years, many regional pig farm outbursts are persistent with the hyperpyrexia of growing and fattening pigs, infectious disease taking the reproductive respiratory obstacle of sow as principal character, often can other cause of diseases of secondary infection, main feature is that full mass-sending is sick, sickness rate is more than 50%, and case fatality rate, at 30-100%, causes serious economic loss to pig farm and pig farmer.General 39.5 DEG C-41.5 DEG C of this sick body temperature, spirit is depressed, and thick disorderly by hair, appetite is absolutely useless, and ear edge cyanosis after the rubescent ear of whole skin, under abdominal part, the many places skin such as extremity is aubergine; Dyspnea is ventral breathing, and some coughs are panted or are irregular breathing, rhinorrhea, happiness is sleeping, discharge of eye increases, what have has a tear speckle, urine amount less, muddiness, some diarrhoea, constipation, it is spherical that feces is.This disease is accredited as through authoritative department the high-pathogenicity blue ear disease that pig blue-ear disease variant viral causes.This disease is imported China into the nineties in last century, and animal health tissue is classified as legal animal epidemic in this world, and China is classified as two class animal epidemics.This disease transmission is fast, and cure rate is low, does not infect people, is not zoonosis.
Current medical domain, to the still complete therapeutic scheme of neither one of this disease, even if there is the also just heavily light treatment of nursing, is cured the symptoms, not the disease, and fails to solve question of substance, and then has ignored balance and the rapport of relevant internal organs function.As: do preventing heatstroke well, improve feeding environment, sterilization, anthelmintic, astragalus polysaccharides drinking-water enhancing body resistance, eliminates complication with antibiotic, corrects acidosis, strengthening fundamental immunity etc.Use antibiotic, vaccine treatment effect not obvious, as overdose uses antibiotic, mortality rate can be higher, and particularly sulfonamides overdose uses and can cause acute kidney enlargement and multiple organs failure; In addition, feeding and management level is higher, aeration-cooling equipment is perfect, the big-and-middle pig farm sickness rate of immunity, treatment specification is relatively low, even the morbidity having, control also relatively easy, and small-scale specialist, to raise family sickness rate mortality rate scattered relatively high, the especially sick pig of small part never received inoculation.
Chinese veterinarian's polarization: this disease belongs to damp and hot and accumulates long-pending, attack of pathogenic warmth in the lung, cloudy bright pathogenic heat, delays due to skin, the pathogen attacking the pericardium adversely, deficiency-heat do not move back.
Pathogenic heat is trouble, in inflammation, and the skin that burns, the Tianjin of burning, forcing blood is gone out, retention of water-damp.In inflammation, eye conjunctiva flushing, discharge of eye increases; Attack of pathogenic warmth in the lung, dyspnea, cough, pants or is irregular breathing; Cloudy bright pathogenic heat, delay skin, whole skin is rubescent, cyanosis, many places skin is purplish red.The pathogen attacking the pericardium adversely, disturb the mind drowsiness, spirit is depressed, appetite is useless absolutely.
Summary of the invention
The object of the invention is to provides a kind of oral liquid medicine that can effectively treat unknown high fever of pigs for above-mentioned technical deficiency, the present invention also aims to provide a kind of method of preparing this oral liquid.
In order to achieve the above object, the technical solution used in the present invention is:
The present invention is based on current medical science to the pathogenetic understanding of unknown high fever of pigs and Therapeutic Principle, the Chinese medicine preparation of making by theory of Chinese medical science prescription with reference to modern pharmacological research achievement.
A kind of oral liquid that is used for the treatment of unknown high fever of pigs of the present invention, its component and parts by weight are: Gypsum Fibrosum 100-200, Rhizoma Anemarrhenae 80-150, Radix Glycyrrhizae 80-150, Rhizoma Coptidis 50-100, Radix Scutellariae 80-150, Fructus Gardeniae 80-150, Cortex Phellodendri 80-150, Radix Isatidis 80-150, Herba Taraxaci 100-200.
Further, be used for the treatment of an oral liquid for unknown high fever of pigs, its component and parts by weight are preferably: Gypsum Fibrosum 150g, Rhizoma Anemarrhenae 100g, Radix Glycyrrhizae 100g, Rhizoma Coptidis 100g, Radix Scutellariae 100g, Fructus Gardeniae 100g, Cortex Phellodendri 100g, Radix Isatidis 100g, Herba Taraxaci 100g.
The present invention realizes the method for another object for the preparation of the oral liquid for the treatment of unknown high fever of pigs, comprises the following steps:
(1) Gypsum Fibrosum of getting metering grinds, and adds the water soaking of 10 times of amounts, soaks 0.5h;
(2) Rhizoma Anemarrhenae, Radix Glycyrrhizae, Radix Scutellariae, Fructus Gardeniae, Cortex Phellodendri, Radix Isatidis, the Herba Taraxaci of getting metering add in step (1), and the decocting that adds 10 times of amounts boils 3 times, each 0.5h,
(3) get in the medicinal liquid that the Rhizoma Coptidis of metering adds step (2) to boil and decoct again 10min;
(4) take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
The present invention can make various dosage forms with acceptable carrier pharmaceutically, as the dosage form such as oral liquid, powder.
In Gypsum Fibrosum Great Cold in oral liquid of the present invention, kind clearing heat in QI system divides excess-heat, is principal agent.Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Cortex Phellodendri hardship, cold, enter the heart, lung, large intestine channel, has the effect of heat clearing and damp drying, eliminating fire and detoxication; It controls Radix Scutellariae at lung, can fall the heat in lung; Fructus Gardeniae is controlled at three warmers, the kind stagnated fire that disappears; Rhizoma Coptidis, Cortex Phellodendri bitter cold, abnormal smells from the patient richness, property heavy and fall, clear damp-heat in lower-JIAO; Radix Isatidis heat-clearing and toxic substances removing, cures mainly the pestilence epidemic disease of various viral infection; Five medicines share, and QI and blood is double to be controlled, clearing heat, purging intense-heat, blood cooling and ecchymoses removing.Effect that the Rhizoma Anemarrhenae, Radix Glycyrrhizae have that invigorating the spleen and replenishing QI, nourishing the lung to arrest cough are relievingd asthma, heat-clearing and toxic substances removing, removing heat from blood promote the production of body fluid.Herba Taraxaci has strong inhibition effect to the various bacteria such as Bacillus typhi, Diplococcus pneumoniae.
The oral liquid making by preparation method of the present invention, the hyperpyrexia of be applicable to damp and hotly to accumulate long-pending, attack of pathogenic warmth in the lung, delaying the growing and fattening pigs due to not moving back of skin, the pathogen attacking the pericardium adversely, deficiency-heat is persistent, the reproductive respiratory obstacle of sow and spirit are depressed, disorderly thick by hair, appetite is absolutely useless, and whole skin is rubescent, cyanosis, dyspnea, cough, asthma, rhinorrhea, the diseases such as discharge of eye increases, constipation.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Be used for the treatment of an oral liquid for unknown high fever of pigs, composed of the following components: Gypsum Fibrosum 150g, Rhizoma Anemarrhenae 100g, Radix Glycyrrhizae 100g, Rhizoma Coptidis 100g, Radix Scutellariae 100g, Fructus Gardeniae 100g, Cortex Phellodendri 100g, Radix Isatidis 100g, Herba Taraxaci 100g.
Above 9 taste medicines, get Gypsum Fibrosum and grind, and add water 10 times and measure, and soak 0.5h, except Rhizoma Coptidis, all the other 7 taste medicines add water 10 times to measure and decoct 3 times, and each 0.5h, adds Rhizoma Coptidis to decoct 10min again after boiling, take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
Embodiment 2
Be used for the treatment of an oral liquid for unknown high fever of pigs, composed of the following components: Gypsum Fibrosum 180g, Rhizoma Anemarrhenae 100g, Radix Glycyrrhizae 100g, Rhizoma Coptidis 80g, Radix Scutellariae 120g, Fructus Gardeniae 100g, Cortex Phellodendri 80g, Radix Isatidis 100g, Herba Taraxaci 100g.
Above 9 taste medicines, get Gypsum Fibrosum and grind, and add water 10 times and measure, and soak 0.5h, except Rhizoma Coptidis, all the other 7 taste medicines add water 10 times to measure and decoct 3 times, and each 0.5h, adds Rhizoma Coptidis to decoct 10min again after boiling, take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
Embodiment 3
Be used for the treatment of an oral liquid for unknown high fever of pigs, composed of the following components: Gypsum Fibrosum 150g, Rhizoma Anemarrhenae 80g, Radix Glycyrrhizae 80g, Rhizoma Coptidis 80g, Radix Scutellariae 120g, Fructus Gardeniae 100g, Cortex Phellodendri 80g, Radix Isatidis 80g, Herba Taraxaci 80g.
Above 9 taste medicines, get Gypsum Fibrosum and grind, and add water 10 times and measure, and soak 0.5h, except Rhizoma Coptidis, all the other 7 taste medicines add water 10 times to measure and decoct 3 times, and each 0.5h, adds Rhizoma Coptidis to decoct 10min again after boiling, take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
Embodiment 4
Be used for the treatment of an oral liquid for unknown high fever of pigs, composed of the following components: Gypsum Fibrosum 200g, Rhizoma Anemarrhenae 150g, Radix Glycyrrhizae 150g, Rhizoma Coptidis 150g, Radix Scutellariae 150g, Fructus Gardeniae 150g, Cortex Phellodendri 150g, Radix Isatidis 150g, Herba Taraxaci 200g.
Above 9 taste medicines, get Gypsum Fibrosum and grind, and add water 10 times and measure, and soak 0.5h, except Rhizoma Coptidis, all the other 7 taste medicines add water 10 times to measure and decoct 3 times, and each 0.5h, adds Rhizoma Coptidis to decoct 10min again after boiling, take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
Embodiment 5
Be used for the treatment of an oral liquid for unknown high fever of pigs, composed of the following components: Gypsum Fibrosum 100, the Rhizoma Anemarrhenae 80, Radix Glycyrrhizae 80, Rhizoma Coptidis 50, Radix Scutellariae 80, Fructus Gardeniae 80, Cortex Phellodendri 80, Radix Isatidis 80, Herba Taraxaci 100.
Above 9 taste medicines, get Gypsum Fibrosum and grind, and add water 10 times and measure, and soak 0.5h, except Rhizoma Coptidis, all the other 7 taste medicines add water 10 times to measure and decoct 3 times, and each 0.5h, adds Rhizoma Coptidis to decoct 10min again after boiling, take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
Clinical therapeutic efficacy:
It is persistent that oral liquid of the present invention is applicable to the hyperpyrexia that porcine nameless high-fever causes, spirit is depressed, disorderly thick by hair, and appetite is absolutely useless, the rubescent cyanosis of whole skin, dyspnea cough, the treatment of the diseases such as asthma and do not contain noxious substance.Different physiological stage pig therapeutic outcomes are shown, this oral liquid has significant curative effect, and cure rate reaches more than 85%.
Further set forth below the beneficial effect of medicine of the present invention by clinical effect trial example, the morbidity pig of different physiological stages is divided at random 2 groups by this test, raises under the same conditions, and 1 group is the group that uses oral liquid of the present invention, and 1 group is test group.
This test is carried out on-scene care taking embodiment mono-as treatment oral liquid medicine, returns to the criterion of normal value (38-40 DEG C) as effectively treating taking the temperature of pig body of falling ill.
Usage and consumption: therapeutic dose 1.2ml/kg, 7 days courses for the treatment of; Make it from drink, seriously ill not trencherman, forces to gavage.
The therapeutic effect of table 1 to ablactational baby pig hyperpyrexia disease
The therapeutic effect of table 2 to growing and fattening pigs hyperpyrexia disease
The therapeutic effect of table 3 to brood sow hyperpyrexia disease
Can find out that by table 1,2,3 this oral medicine liquid has good curative effect to unknown high fever of pigs, cure rate is more than 85%.
Claims (3)
1. be used for the treatment of an oral liquid for unknown high fever of pigs, its component and parts by weight are: Gypsum Fibrosum 100-200, Rhizoma Anemarrhenae 80-150, Radix Glycyrrhizae 80-150, Rhizoma Coptidis 50-100, Radix Scutellariae 80-150, Fructus Gardeniae 80-150, Cortex Phellodendri 80-150, Radix Isatidis 80-150, Herba Taraxaci 100-200.
2. a kind of oral liquid that is used for the treatment of unknown high fever of pigs according to claim 1, its component and parts by weight are preferably: Gypsum Fibrosum 150g, Rhizoma Anemarrhenae 100g, Radix Glycyrrhizae 100g, Rhizoma Coptidis 100g, Radix Scutellariae 100g, Fructus Gardeniae 100g, Cortex Phellodendri 100g, Radix Isatidis 100g, Herba Taraxaci 100g.
3. a kind of oral liquor that is used for the treatment of unknown high fever of pigs as claimed in claim 1, comprises the following steps:
(1) Gypsum Fibrosum of getting metering grinds, and adds the water soaking of 10 times of amounts, soaks 0.5h;
(2) Rhizoma Anemarrhenae, Radix Glycyrrhizae, Radix Scutellariae, Fructus Gardeniae, Cortex Phellodendri, Radix Isatidis, the Herba Taraxaci of getting metering add in step (1), and the decocting that adds 10 times of amounts boils 3 times, each 0.5h,
(3) get in the medicinal liquid that the Rhizoma Coptidis of metering adds step (2) to boil and decoct again 10min;
(4) take out decoction liquor, be cooled to room temperature adding distil water and be adjusted to 1000ml, filtration, fill, sterilizing and get final product.
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| CN103479860B (en) * | 2013-09-26 | 2015-06-03 | 青岛农业大学 | Traditional Chinese medicine composition for treating PRRS (Porcine Reproductive and Respiratory Syndrome) and preparation method and application thereof |
| CN105194377A (en) * | 2015-10-09 | 2015-12-30 | 龚相才 | Method for epidemically preventing porcine mouth-foot disease |
| CN105935418A (en) * | 2016-04-18 | 2016-09-14 | 六枝特区垄鑫盛泰农业发展有限公司 | Medicine for treating hyperpyrexia syndromes and preparation method thereof |
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