CN106039074A

CN106039074A - Tablets for treating canine parvovirus

Info

Publication number: CN106039074A
Application number: CN201610548199.0A
Authority: CN
Inventors: 张绪伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-12
Filing date: 2016-07-12
Publication date: 2016-10-26

Abstract

The invention provides tablets for treating the canine parvovirus. The tablets are prepared from carbonized human hair, charred sophora flowers, honeysuckle flowers, coptis roots, cortex phellodendri, semen plantaginis, roots of Chinese pulsatilla, portulacae herba, hairyvein agrimonia herb and buds, red halloysite, rhizoma corydalis, poria cocos, red yeast rice, radix codonopsis, roasted rhizoma atractylodis macrocephalae, rhizoma atractylodis, oven earth, radix bupleuri, rhizoma cimicifugae and radix pueraiae. The tablets have a remarkable treatment effect on the canine parvovirus, reduce the death rate of diseased dogs and meanwhile improve the general condition of diseased dogs.

Description

The tablet for the treatment of Canine Parvovirus

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of tablet for treating Canine Parvovirus.

Background technology

Canine Parvovirus is that the Kelly and Canadian Thomson etc. of Australia in 1978 are simultaneously from the disease suffering from enteritis Dog feces separates acquisition, from finding this virus so far, the most all has popular, be the topmost strong of harm dog class One of infectious disease.The U.S., Britain, Germany, France, Italy, the state such as Russian and Japanese are found that this virus the most in succession.Serum Learning investigation display, CPV positive serum can trace back to 1974-1976 the earliest in Europe；In the U.S., Canada, Japan and Australia Big Leah can trace back to 1978.Superfine in order to be different from the dog being separated to from healthy dogs feces by Binn et al. 1967 Small virus (Minutevirusofcanine, MVC) (custom also on be called CPV-1) and by the viral nomenclature found later be Canine Parvovirus 2 type (CPV-2).

CPV main infection dog, especially pup, infectiousness is extremely strong, and mortality rate is the highest.The most all can fall ill, with winter, spring Multiple.Feeding and management condition cataclysm, long-distance transport, cold, crowded primary disease all can be promoted to occur.Sick dog is major source of infection, vomits Anabole, saliva, feces all has a large amount of virus.Rehabilitation dog still can pass through the outside toxin expelling of feces for a long time.Evidence suggests people, louse, Fly and Blatta seu periplaneta can become the mechanical carrier of CPV.Healthy dogs directly contacts with sick dog or band poison dog, or feedstuff through polluting and Drinking-water passes through digestive tract infection.

Dog is main natural reservoir (of bird flu viruses), other Canis animalss, can also feel such as prairie wolf, Bushdog, Cerdocyon and hyena etc. Dye.Along with virus antigen drifts about, virus can infect the animals such as cat, Little Bear, Nyctereutes procyonoides.

It is anxious that dog infects CPV morbidity, and mortality rate is high, normal break out and spread；All ages and classes, sex, the dog of kind all can be felt Dye.Clinical manifestation is vomiting, diarrhoea (or hemorrhagic diarrhea) suffer from dog, CPV infects positive dog can account for 29.8- 46.2%.Wherein dog below 6 monthly ages is the most susceptible, and the ratio accounting for CPV infected dogs sum may be up to 75%, and this age in days section infects It is high that dog mortality rate relatively larger than 6 monthly age suffers from dog；The most relatively low more than 12 monthly age dog sickness rate.Studies have found that, male dogs is more female Property dog the most susceptible, but for suffering from dog less than 6 monthly ages, age, sex and kind infect to CPV do not have relevant.For 6- 18 the infected dogs survival rate researchs of week old CPV find, male and female between, between age groups, HI antibody titer ＜ 1: 80 Group and 1: 160 group of significant difference.

Sick dog and recovery band poison dog are the sources of infection of primary disease.Sick dog is outwardly arranged through feces, urine, saliva and vomitus Poison；Recovery band poison dog may pollute feedstuff, drinking-water, tableware and surrounding enviroment from the medium-term and long-term toxin expelling of fecaluria.And disease dog is generally in sense Within after dye 7-8 days, peaked by feces toxin expelling, drastically reduce when 10-11 days.Evidence suggests, people, fly and Blatta seu periplaneta etc. are all The mechanical carrier of CPV can be become.The route of infection that it is generally acknowledged this disease are digestive tract, and susceptible animal is mainly by directly or indirectly Contact and infect.

Primary disease occurs without obvious seasonality.General summer, autumn seasonal prevalence.Cold weather, temperature cataclysm, sanitary condition Difference and accompanying infection all can increase the weight of the state of an illness and improve mortality rate.

3-5 days incubation period of this disease, mostly occurring behind firm ring change border (pup as newly bought), have a bath, surfeit is inducement.This disease Majority presents enteritis syndrome, and minority presents myocarditis syndrome.

Enteritis disease dog initial stage spirit is depressed, anorexia, accidental heating, soft stool or slightly vomit, and develops into subsequently and frequently vomits Acutely suffer from diarrhoea in Tuhe.Originally feces gray, yellow or milky, band g., jelly-like mucus, discharge thereafter stench soy sauce sample or Fructus Lycopersici esculenti juice sample of blood is just.Sick dog rapid dehydration, becomes thin, proscopiny, and in disorder by hair, skin is nonelastic, ear nose, coolness of extremities, essence God is the most depressed, shock, dead.From disease, just symptom is slightly to being seriously usually no more than 2 days, and the whole course of disease is usually no more than one Week.

Tentative diagnosis can be carried out clinically according to the cardinal symptom of routine blood test testing result and primary disease.Routine blood test detection is red carefully Born of the same parents' hematocrit increases, and wbc value is normal or on the low side, often points out virosis.Sick dog excretion Fructus Lycopersici esculenti juice sample or soy sauce belt transect fishy odor Hemafecia be the characteristic symptom of primary disease, can be as first visit foundation.

Using Canine Parvovirus gold colloidal quick diagnosis reagent paper to carry out the diagnosis of canine parvovirus disease more.This method is easy to be fast Speed, accuracy rate is high.Dip the feces of disease dog with cotton swab or vomitus immerses and mixes equipped with in the plastic tube of normal saline, by 3～4 Drip supernatant drop in reagent paper reacting hole, stand 3～5min, as C and T corresponding position all occurs that red line is positive.

Find that primary disease should carry out isolated rearing immediately.Prevent disease dog from contacting with healthy dogs, to doghouse with sick dog breeders personnel And place sterilizes repeatedly with 2% Caustic soda water or 10-20% bleaching powder etc..To remind especially, if your family once had, and this occurs Sick doggie, even if environment is the most sterilized, also must not take other doggies not playing all vaccines, otherwise home again Morbidity will soon be infected.

It is mainly symptomatic treatment clinically and coordinates hyper-immune serum and mab treatment.In a few days ago taboo that vomiting is serious Food prohibits water, antiinflammatory in infusion process, stops blooding, correction acidosis, cooperation serum, anti-parvovirus monoclonal antibody, interferon etc., Until not vomitting, when not suffering from diarrhoea, the most heuristically feed light food.But its cure rate is relatively low, clinical efficacy is relatively Difference.

Recently as the growth in the living standard of people, people raise the custom of dog class particularly pet dog increasingly Many, the incidence rate of canine parvovirus disease is constantly mentioned, and people use the treatment means of doctor trained in Western medicine the most mostly, spends a large amount of Money, curative effect is poor, and the misery born of pet dog is relatively big, and dog class and people are all mammal, for its function, disease Pathological changes, the understanding of the side's of condemning medicine law can also apply corresponding theory of Chinese medical science to carry out direction of medication usage.It has recently been found that middle recurrence due to taking drug There is clear and definite curative effect side for the treatment of canine parvovirus disease, and how to admix in dog food or drinking-water by Chinese medicine preparation, digestion Road absorbs, and is possible not only to improve disease dog immunity, kill digestive tract virus, can improve disease dog clinical manifestation simultaneously, and the traditional Chinese medical science is recognized For " depositing one point of gastric qi, just have a mitogenetic machine ", protecting the Gu of taste is a traditional Chinese medical science spotlight in animal medicine is put into practice and spy Color.

Summary of the invention

The technical problem to be solved is to provide a kind of Chinese medicinal tablet for treating Canine Parvovirus, and it is to dog Parvovirus therapeutic effect is notable, reduces sick dog case fatality rate, improves the ordinary circumstance of sick dog simultaneously.

For solving above-mentioned technical problem, the present invention provides a kind of medicine for treating Canine Parvovirus, its raw material medicated bag Include charred Radix Sanguisorbae, charred Flos Sophorae, Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri, Semen Plantaginis, the Radix Pulsatillae, Herba Portulacae, Herba Agrimoniae, Halloysitum Rubrum, Rhizoma Corydalis, Fu Siberian cocklebur, Monas cuspurpureus Went, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Atractylodis, humus flava usta, Radix Bupleuri, Rhizoma Cimicifugae and Radix Puerariae.

Wherein, in described medicine, the weight portion of each crude drug is respectively charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 8 parts～12 parts, gold silver Spend 13 parts～17 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 10 parts～14 parts, Semen Plantaginis 13 parts～17 parts, the Radix Pulsatillae 13 parts～17 parts, Herba Portulacae 28 parts～32 parts, Herba Agrimoniae 28 parts～32 parts, Halloysitum Rubrum 8 parts～12 parts, Rhizoma Corydalis 28 parts～32 parts, 58 parts～62 parts of Poria, 18 parts～22 parts of Monas cuspurpureus Went, Radix Codonopsis 38 parts～42 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts～42 parts, Rhizoma Atractylodis 18 parts～22 parts, humus flava usta 40 parts, Radix Bupleuri 6 parts～10 parts, Rhizoma Cimicifugae 6 parts～10 parts, Radix Puerariae 28 parts～32 parts.

Wherein, in described medicine, the weight portion of each crude drug is respectively charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 10 parts, Flos Lonicerae 15 Part, Rhizoma Coptidis 20 parts, Cortex Phellodendri 12 parts, Semen Plantaginis 15 parts, the Radix Pulsatillae 15 parts, Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Halloysitum Rubrum 10 parts, Rhizoma Corydalis 30 parts, 60 parts of Poria, 20 parts of Monas cuspurpureus Went, Radix Codonopsis 40 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Rhizoma Atractylodis 20 parts, humus flava usta 40 parts, Radix Bupleuri 8 parts, Rhizoma Cimicifugae 8 parts, Radix Puerariae 30 parts.

Wherein, described medicine is prepared as tablet.

The preparation method of described tablet particularly as follows:

The first step, pulverizes each crude drug respectively, mixes, use water extraction；

Second step, extracting solution concentrates, it is thus achieved that the effective extract component of medicine；

3rd step, second step obtain the effective extract component of medicine mix homogeneously according to the mass ratio of 3: 2 with starch, then Adding excipients magnesium stearate, the addition of magnesium stearate is the 5% of starch and effective extract component mixing quality sum, compacting In flakes, it is thus achieved that tablet.

Wherein, the described first step is specially further and is pulverized respectively by each crude drug, mixes, adds mixture quality The water boil of 10 times, maintains 2 hours, filters, and filtering residue adds the water boil of mixture quality 6 times again, maintains 1 hour, filters, two Secondary filtrate mixes, and concentrates for second step.

Wherein, described second step is that the hybrid filtering liquid first step obtained concentrates further, it is thus achieved that 60 DEG C of relative densities The mastic of 1.25, for the 3rd step.

Useful technique effect

The Chinese medicinal tablet for treating Canine Parvovirus that the present invention provides, it is notable to Canine Parvovirus therapeutic effect, Reduce sick dog case fatality rate, improve the ordinary circumstance of sick dog simultaneously.

Detailed description of the invention

Canine parvovirus infection is to annoying people pet feeding dog at present and plant the disease that dog base cultivates in a large number, ill Dog class mortality rate is higher.It is mainly symptomatic treatment clinically and coordinates hyper-immune serum and mab treatment.Serious in vomiting A few days ago water, antiinflammatory in infusion process are prohibited in fasting, stop blooding, correction acidosis, cooperation serum, anti-parvovirus monoclonal antibody, Interferon etc., until not vomitting, the most heuristically feed light food when not suffering from diarrhoea.But its cure rate is relatively low, faces Bed curative effect is poor.

We are through carrying out clinical research discovery, based on enteritis syndrome after morbidity to a large amount of ill dog classes.Enteritis disease Dog initial stage spirit is depressed, anorexia, accidental heating, soft stool or slightly vomit, and develops into frequently vomiting and violent diarrhoea subsequently.Rise Just feces gray, yellow or milky, band g., jelly-like mucus, discharge thereafter the soy sauce sample of stench or Fructus Lycopersici esculenti juice sample of blood just.Sick Dog rapid dehydration, becomes thin, and proscopiny is in disorder by hair, and skin is nonelastic, ear nose, coolness of extremities, and spirit is the most depressed, shock, Dead.From disease, just symptom is slightly to being seriously usually no more than 2 days, and the whole course of disease is usually no more than one week.

Dog is Mammalia Carnivora Canidae Canis animal, and Chinese medicine is long-standing for the use of dog class, and beast in ancient times Doctor and modern veterinary development find, the disease of dog and medication can combine with theory of Chinese medical science completely.For doctor trained in Western medicine for Canine parvovirus infection is without good Therapeutic Method, and the use of Chinese medicine brings hope to undoubtedly the healing of this disease.To ill dog Carrying out dialectical analysis, this disease is hemorrhagic enteritis, is classified as distemper epidemic disease, fall ill hurried, generate heat, suffer from abdominal pain, abdominal distention, vomiting, under The hemafecia that dysentery corruption is stench is main performance.Treatment is when heat-clearing and toxic substances removing, cooling blood for hemostasis, yang invigorating antidiarrheal, drying damp and strengthening spleen.

The present invention provides a kind of medicine for treating Canine Parvovirus, and its crude drug is by charred Radix Sanguisorbae, charred Flos Sophorae, gold silver Flower, Rhizoma Coptidis, Cortex Phellodendri, Semen Plantaginis, the Radix Pulsatillae, Herba Portulacae, Herba Agrimoniae, Halloysitum Rubrum, Rhizoma Corydalis, Poria, Monas cuspurpureus Went, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Atractylodis, humus flava usta, Radix Bupleuri, Rhizoma Cimicifugae and Radix Puerariae are constituted.

The present invention is with charred Radix Sanguisorbae, Rhizoma Coptidis, humus flava usta three medicine for core medication, and charred Radix Sanguisorbae is bitter, sour, puckery, is slightly cold, return Liver Channel, Large intestine channel, has cooling blood for hemostasis, effect of removing toxic substances sore, clinical for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle Sores etc. have well effect, the particularly traditional Chinese medical science to think " blood obtains black, stops ", strengthen its removing toxic substances and hold back effect of wound hemostasis after parch to black； Rhizoma Coptidis has heat clearing and damp drying, effect of eliminating fire and detoxication, is clinically used for damp and hot feeling of fullness, vomits acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, Hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache is quenched one's thirst, and carbuncle furuncle, Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting, is used for simultaneously Incoordination between the liver and stomach, vomits acid regurgitation, and the treatment for primary disease is i.e. verified, suited the medicine to the illness again, is the treatment of disease combination, modern medicine study In Rhizoma Coptidis, effective ingredient has significant antibacterial action, antivirus action, ameba is also had to good inhibiting effect, Additionally, Rhizoma Coptidis can also antiinflammatory, health diarrhoea, after acting on disease dog, blood circulation can be had well regulate work with antipyretic-antalgic With；Using humus flava usta to have cough-relieving inverse, hemostasis, effect of subduing inflammation poison, because charred Radix Sanguisorbae, Rhizoma Coptidis is cold medicine, is anti- Only the coolest gripping, therefore add and not only can stop blooding with spleen invigorating, but also can help its cold humus flava usta of system, using medicines of both cold and hot natures simultaneously, malicious heresy can be gone, dysentery can Puckery, hematochezia can stop, and in the hope of effect of fullying recover from an illness, it is monarch drug group altogether that three medicines share, and we have also been made relevant research for monarch drug consumption, Radix Sanguisorbae Charcoal: Rhizoma Coptidis: when humus flava usta is 1: 1: 2, its best results, if reducing the consumption of charred Radix Sanguisorbae, then hemostatic function weakens, if reducing Huang The amount of being used in conjunction, then there will be anti-diarrhea effect and lower, and antivirus action weakens, if reducing the consumption of humus flava usta, then warming the meridian for stopping bleeding is made With reduction, increase relative to cold and cool medicine ratio, have cool gripping, close door and stay Kou Zhizhuan, if reducing charred Radix Sanguisorbae, the consumption of Rhizoma Coptidis, i.e. The consumption of humus flava usta increases relatively, then have and significantly help heat effect, with the method for the treatment of phase of the traditional Chinese medical science " treating heat syndrome with cold-natured drugs, treating cold syndrome with hot-nature drugs " The back of the body, it is impossible to quick-acting.Addition charred Flos Sophorae, the Radix Pulsatillae, Herba Portulacae three medicine coordinate with monarch drug charred Radix Sanguisorbae, Flos Sophorae bitter in the mouth, and property is put down, nontoxic, There is effect of heat clearing away, removing heat from blood, hemostasis, blood pressure lowering.Parch to black uses herein, strengthens its removing heat from blood, hemostasia effect, and this medicine has preferably simultaneously Anthelmintic action, strengthen blood capillary resistance, reduce vascular permeability, have good therapeutical effect for hemorrhage；Dens Equi Herba Amaranthi tricoloris has good therapeutical effect for all kinds of enteritis, dysentery etc., can be with heat-clearing and toxic substances removing, parasite killing only profit；Hoary hair has asked very well Effect of heat-clearing and toxic substances removing, be usually used in the symptoms such as lower profit band blood, there is the effect of good antioxidation, antiinflammatory, have parasite killing simultaneously Bacteriostasis efficacy, coordinates monarch drug charred Radix Sanguisorbae clearing away heat and cooling blood, hemostasis only profit, addition Flos Lonicerae, Cortex Phellodendri, Semen Plantaginis to coordinate monarch drug Rhizoma Coptidis dry Dairrhea caused by pathogenic damp fire, heat-clearing and toxic substances removing, dampness removing only profit, modern medicine study, Flos Lonicerae antiinflammatory, antivirus action are obvious, not only body animal Experiment has well effect, and antibacterial, virus for isolated culture also have killing action, Rhizoma Coptidis, Cortex Phellodendri, Semen Plantaginis, the Radix Pulsatillae Four medicines share bitter cold sedimentation, heat clearing and damp drying, effect of eliminating fire and detoxication, return kidney channel, bladder warp, can be descending with heat conduction, diuresis With real stool, add the medicines such as Halloysitum Rubrum, Poria, Monas cuspurpureus Went, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Atractylodis, coordinate monarch drug humus flava usta only to play warming the meridian altogether Blood, dampness removing and diarrhea-relieving, strong the spleen governs the blood, wherein Halloysitum Rubrum sweet in the mouth, acid, puckery, warm in nature, there are astringing intestine to stop diarrhea, hemostasia effect, especially for this disease Under middle and late stage, profit pus and blood has good therapeutical effect, addition Poria, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched) tonification lung spleen, spleen invigorating to help fortune, play very well Anti-diarrhea effect, the spleen governs the blood, the strong fortune of temper then system blood has the right, and The spleen and stomach provide the material basis of the acquired simultaneously, deposits to obtain a gastric qi, just has portion Life, three medicines share, and it will be congenital to support for the day after tomorrow to play benefit altogether, and QI and blood is biochemical active, and whole body healthy energy fills Sheng, it is possible to anti-heresy is gone out, all medicines Share, be ministerial drug altogether；Add a small amount of Monas cuspurpureus Went, have good spleen invigorating to help running use, but Chinese medicine preparation of the present invention is more importantly Promote the function of becoming thoroughly decomposed of stomach with Monas cuspurpureus Went, regulate effect of archenteric flora, the enteritis caused after virus or antibacterial are infected, Sick dog vomiting, have loose bowels after, alteration of intestinal flora, its therapeutic effect is especially notable, and retention of water-damp within middle-JIAO is one of reason of vomiting, tells Rushing down and determine without complete gas afterwards, Rhizoma Atractylodis coordinate with Rhizoma Atractylodis Macrocephalae (parched), Poria two medicine, play drying damp and strengthening spleen, stomach function regulating removing dampness effect altogether, add a small amount of celestial Crane grass, has the wet effect in the most sharp blood, adds Rhizoma Corydalis regulating QI to relieve pain, blood-activating and qi-promoting, and sick dog cannot use language and the mankind Exchange, however we it is envisioned that people obtained the disease such as dysentery, enteritis time, many abdominal pain diarrheas, vomiting etc., therefore, this Invention Chinese medicine preparation adds Rhizoma Corydalis, plays analgesic efficacy, and not available for other prescriptions, all medicines share as adjuvant drug；Additionally, it is clear Gas, lower, gives birth to lientery, and Chinese medicine preparation of the present invention adds a small amount of Radix Bupleuri, Rhizoma Cimicifugae, Radix Puerariae yang invigorating antidiarrheal, for Radix Bupleuri, the use of Rhizoma Cimicifugae Amount is strict controlled in below 10 weight portions, and heavy dose of use is then without yang invigorating antidiarrheal efficacy, and it is cloudy that a large amount of use Radix Bupleuri also can consume impairing the liver, Add the Radix Puerariae of larger dose, be possible not only to yang invigorating antidiarrheal, and have promoting the production of body fluid to quench thirst effect, vomit, have loose bowels and the most serious be exactly Dehydration, after using Radix Puerariae, can maintain blood volume, and the first aid for sick dog has a very important role.

In sum, Chinese medicine preparation of the present invention has the effect well treating Canine parvovirus infection dog class, and leads to Clinical research and experimentation are crossed it was confirmed its curative effect, it is adaptable to larger range of promote the use of.

In described medicine, the weight portion of each crude drug is respectively charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 8 parts～12 parts, Flos Lonicerae 13 parts ～17 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 10 parts～14 parts, Semen Plantaginis 13 parts～17 parts, the Radix Pulsatillae 13 parts～17 parts, Herba Portulacae 28 parts～ 32 parts, Herba Agrimoniae 28 parts～32 parts, Halloysitum Rubrum 8 parts～12 parts, Rhizoma Corydalis 28 parts～32 parts, 58 parts～62 parts of Poria, Monas cuspurpureus Went 18 Part～22 parts, Radix Codonopsis 38 parts～42 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts～42 parts, Rhizoma Atractylodis 18 parts～22 parts, humus flava usta 40 parts, Radix Bupleuri 6 parts～ 10 parts, Rhizoma Cimicifugae 6 parts～10 parts, Radix Puerariae 28 parts～32 parts.

Most preferably, in described medicine, the weight portion of each crude drug is further preferably respectively charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 10 Part, Flos Lonicerae 15 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 12 parts, Semen Plantaginis 15 parts, the Radix Pulsatillae 15 parts, Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Halloysitum Rubrum 10 parts, Rhizoma Corydalis 30 parts, 60 parts of Poria, 20 parts of Monas cuspurpureus Went, Radix Codonopsis 40 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Rhizoma Atractylodis 20 parts, humus flava usta 40 Part, Radix Bupleuri 8 parts, Rhizoma Cimicifugae 8 parts, Radix Puerariae 30 parts.

Each crude drug pharmacology is as follows:

Charred Radix Sanguisorbae: for the Preparation process product of Radix Sanguisorbae, bitter in the mouth, acid, puckery, cold nature, return liver, large intestine channel, there is cooling blood for hemostasis, The cards such as effect of removing toxic substances sore, cures mainly and have blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.

Charred Flos Sophorae: bitter in the mouth, cool in nature, return liver, large intestine channel, there is heat clearing away, removing heat from blood, effect of hemostasis, cure mainly discharging fresh blood stool, hemorrhoid Blood, hematuria, stranguria with blood, metrorrhagia, epistaxis, under dysentery with red and white feces, wind heat conjunctival congestion, skin sore, prevention of stroke etc. is demonstrate,proved.

Flos Lonicerae: latin name lonicerae japonicae flos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have The effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is relatively contained, or epidemic febrile disease is from the beginning of pathogenic heat still At the part of the body cavity above the diaphragm housing the heart and lungs the most descending time；Pyretic toxicity dysentery, stool hematochezia；Fever disease in summer is demonstrate,proved.

Rhizoma Coptidis: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, stomach, large intestine channel, has the work of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight With, it is longer than the fire of removing pathogen in the heart warp, can be used for treating the prosperous caused dysphoria and insomnia of heart-fire, and the high fever coma of epidemic febrile disease, vexed, mouth Yearningly；Can be additionally used in damp and hot caused dysentery, tenesmus；Pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis etc. are demonstrate,proved.

Cortex Phellodendri: bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, there is heat clearing and damp drying, effect of eliminating fire and detoxication.Cure mainly damp and hot Dysentery, jaundice, leukorrhagia, pyretic stranguria, tinea pedis, flaccidity wards off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus, hyperactivity of fire caused by deficiency of YIN, Night sweat hectic fever due to YIN-deficiency etc. are demonstrate,proved.

The Radix Pulsatillae: bitter in the mouth, cold in nature, enters stomach, large intestine channel, has heat-clearing and toxic substances removing, and the effect of eliminating pathogenic heat from blood to cure dysentery is mainly used in gastrointestinal Having damp and hot stagnant heating stomachache, dysentery pus and blood, tenesmus etc. is demonstrate,proved.

Herba Portulacae: latin name Portulacae herba, sour in the mouth, cold in nature, return large intestine, Liver Channel, there is heat-clearing and toxic substances removing, diuretic Drying, dissipate blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, effect of hemostasis removing heat from blood, cure mainly dysentery, enteritis, nephritis, puerperal, uterus went out The diseases such as blood, has blood in stool, mastitis.

Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is put down, and GUIXIN, Liver Channel have astringing to arrest bleeding, only Effect of dysentery parasite killing, cures mainly various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, labor The de-power of wound, carbuncle, traumatic injury, wound hemorrhage etc. is demonstrate,proved.

Halloysitum Rubrum: sweet in the mouth, acid, puckery, warm in nature, to return large intestine, stomach warp, there is astringing intestine to stop diarrhea, hemostasis, promoting tissue regeneration and ulcer healing effect, for for a long time Rush down chronic dysentery, fecal blood, bleeding not during menses；The cards such as external treatment skin infection is burst for a long time and do not held back, eczema pus contamination.

Rhizoma Corydalis: acrid in the mouth, hardship, warm in nature, enter liver, spleen channel, there is promoting blood circulation to remove blood stasis, the effect of promoting the circulation of QI to relieve pain, for stagnation of QI blood The various pains card that the stasis of blood causes, particularly trusted subordinate's pain is commonly used, and such as depressed liver and heat transmission, the gastral cavilty abdominal distention of incoordination between the liver and stomach, has analgesic Effect.

Poria: sweet in the mouth, light, property is put down, is entered the heart, lung, spleen, kidney channel, have eliminating dampness and diuresis, the effect of spleen invigorating mind calming, be mainly used in The edema of retention of water-damp, dysuria；The pyretic stranguria of damp-heat accumulation, the stagnation of the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention, epilepsy etc. are demonstrate,proved.

Monas cuspurpureus Went: latin name Fermentum Rubrum, sweet in the mouth, warm in nature, return liver, spleen, stomach, large intestine channel, there is blood circulation promoting and blood stasis dispelling； Effect of strengthening the spleen to promote digestion.Cure mainly eating accumulation；Distension and fullness in the abdomen；Red white dysentery；Prolonged lochia；Traumatic injury etc. are demonstrate,proved.

Radix Codonopsis: sweet in the mouth, property is flat, returns lung, spleen channel, has QI invigorating strengthening the spleen, and effect of nourishing blood to promote the production of body fluid cures mainly deficiency of both the splenic and pulmonary QI or gas The fatigue and weakness of blood two void, breathing hard, the symptom such as cough spontaneous perspiration, Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjusts regulating the function of middle-JIAO, has the work nourished blood concurrently Put down by, its property, spleen invigorating fortune and the driest；Flavour is cloudy and the wettest, it is possible to improves the immune state of body, improves resistance against diseases.

Rhizoma Atractylodis Macrocephalae (parched): sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, activating the spleen is moisturized Effect, is mainly used in the feeling of fullness diarrhoea caused by dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema；The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia Leak down, proctoptosis with chronic dysentery；The card such as solid, sweating due to debility spontaneous perspiration in the playing of deficiency of the spleen causing weakness of QI.

Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, the effect of improving eyesight, mainly use In the stomachache dysentery of retention of dampness in middle-JIAO, the abdominal distention pain of incoordination between the spleen and stomach, vomit indigestion and loss of appetite；The abdomen side of body distending pain, the vomiting with acid regurgitation of incoordination between the liver and stomach； And the card such as the anemofrigid-damp arthralgia of the outer strongly fragrant meridians of cold-damp.

Humus flava usta: acrid in the mouth, slightly warm in nature, return spleen, stomach warp, there is warming middle-JIAO for easing the stomach, preventing or arresting vomiting, hemostasis, effect of antidiarrheal.Cure mainly spleen The cards such as insufficiency of stomach is trembled with fear, and vomiting is felt sick, and spits blood, epistaxis, and hematuria is had blood in stool, metrorrhagia, insufficiency of the spleen chronic diarrhea.

Radix Bupleuri: latin name bupleuri radix, for umbelliferae bupleurum or the dry root of Radix Bupeuri Scorzonerfolii., bitter in the mouth, property It is slightly cold, returns liver, gallbladder meridian, there is evacuation and bring down a fever, effect of yang invigorating soothing liver-QI, cure mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of liver-QI gas Stagnant, sternal rib pain, proctoptosis, the cards such as uterus comes off, menoxenia.

Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enter lung, spleen, stomach, large intestine channel, have and deliver rash, heat-clearing and toxic substances removing, rise and lift sun Effect of gas.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle；Proctoptosis, uterine prolapse etc. is demonstrate,proved.

Radix Puerariae: latin name Puerariae Lobatae Radix, sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration gastric qi, Clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, raw positive, oozes the effect of rash, is mainly used in fever caused by exogenous pathogens, and headache, stiff nape and back, calentura is thirsty, disappears Yearningly；Diarrhea due to hypofunction of the spleen, clear YANG failing to ascend etc. is demonstrate,proved.

The medicine that the present invention provides can be prepared as tablet or powder, is preferably prepared to tablet.

The preparation method of described tablet particularly as follows:

The described first step is specially further and is pulverized respectively by each crude drug, mixes, adds mixture quality 10 times Water boil, maintain 2 hours, filter, filtering residue adds the water boil of mixture quality 6 times again, maintains 1 hour, filtration, twice mistake Filtrate mixes, and concentrates for second step.

Described second step is that the hybrid filtering liquid first step obtained concentrates further, it is thus achieved that 60 DEG C of relative densities 1.25 Mastic, for the 3rd step.

Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet 1

By charred Radix Sanguisorbae 20g, charred Flos Sophorae 10g, Flos Lonicerae 15g, Rhizoma Coptidis 20g, Cortex Phellodendri 12g, Semen Plantaginis 15g, Radix Pulsatillae 15g, Herba Portulacae 30g, Herba Agrimoniae 30g, Halloysitum Rubrum 10g, Rhizoma Corydalis 30g, Poria 60g, Monas cuspurpureus Went 20g, Radix Codonopsis 40g, Rhizoma Atractylodis Macrocephalae (parched) 40g, grey Art 20g, humus flava usta 40g, Radix Bupleuri 8g, Rhizoma Cimicifugae 8g, Radix Puerariae 30g pulverize respectively, mix, and add the water boil of 4.7kg, maintain 2 hours, filtering, filtering residue adds the water boil of 3kg again, maintains 1 hour, filters, twice filtrate mixing, concentrates, it is thus achieved that 60 DEG C The mastic of relative density 1.25, takes mastic 300g and mixs homogeneously with starch 200g, adds excipients magnesium stearate 25g, compacting In flakes, it is thus achieved that tablet 1,0.5g/ sheet.

Comparative example 1 tablet 2

By charred Radix Sanguisorbae 10g, charred Flos Sophorae 10g, Flos Lonicerae 15g, Rhizoma Coptidis 10g, Cortex Phellodendri 12g, Semen Plantaginis 15g, Radix Pulsatillae 15g, Herba Portulacae 30g, Herba Agrimoniae 30g, Halloysitum Rubrum 10g, Rhizoma Corydalis 30g, Poria 60g, Monas cuspurpureus Went 20g, Radix Codonopsis 40g, Rhizoma Atractylodis Macrocephalae (parched) 40g, grey Art 20g, humus flava usta 40g, Radix Bupleuri 8g, Rhizoma Cimicifugae 8g, Radix Puerariae 30g pulverize respectively, mix, and add the water boil of 4.7kg, maintain 2 hours, filtering, filtering residue adds the water boil of 3kg again, maintains 1 hour, filters, twice filtrate mixing, concentrates, it is thus achieved that 60 DEG C The mastic of relative density 1.25, takes mastic 300g and mixs homogeneously with starch 200g, adds excipients magnesium stearate 25g, compacting In flakes, it is thus achieved that tablet 2,0.5g/ sheet.

Comparative example 2 tablet 3

By charred Radix Sanguisorbae 20g, charred Flos Sophorae 10g, Flos Lonicerae 15g, Rhizoma Coptidis 20g, Cortex Phellodendri 12g, Semen Plantaginis 15g, Radix Pulsatillae 15g, Herba Portulacae 30g, Herba Agrimoniae 30g, Halloysitum Rubrum 10g, Rhizoma Corydalis 30g, Poria 60g, Monas cuspurpureus Went 20g, Radix Codonopsis 40g, Rhizoma Atractylodis Macrocephalae (parched) 40g, grey Art 20g, humus flava usta 20g, Radix Bupleuri 8g, Rhizoma Cimicifugae 8g, Radix Puerariae 30g pulverize respectively, mix, and add the water boil of 4.7kg, maintain 2 hours, filtering, filtering residue adds the water boil of 3kg again, maintains 1 hour, filters, twice filtrate mixing, concentrates, it is thus achieved that 60 DEG C The mastic of relative density 1.25, takes mastic 300g and mixs homogeneously with starch 200g, adds excipients magnesium stearate 25g, compacting In flakes, it is thus achieved that tablet 3,0.5g/ sheet.

Toxicological study

Because the dog class disease that Canine parvovirus infection causes, its clinical onset has own characteristic, from morbidity to dead one As less than one week, therefore, the medicine for treatment for this disease also gets a grip on time window, and medication was less than 7 days.In order to verify The clinical drug safety of Chinese medicinal tablet of the present invention, therefore set up anxious toxicity test, probe in 7 days, take in a large number in the present invention Whether the sick dog of tablet there will be clinical toxicity.

Animal origin: certain dog base, Dezhou, Shandong is uninfected by tiny dog 20, kind, weight, sex Ask.

Experimental drug: the tablet 1 of the embodiment of the present invention 1 preparation, 0.5g/ sheet, containing Effective Component of Chinese Medicine 0.3g/ sheet.

Packet is administered:

Experimental group: admix after being ground by tablet 1 in dog feed, calculates according to Canis familiaris L. daily ingestion of dog food weight, every dog Taking in Effective Component of Chinese Medicine of the present invention is 55g/kg/d, is equivalent to be clinically used for the dosage (2.4g/kg/d) of disease dog 22.92 times.

Matched group: give experimental group same with equivalent starch, medication and dosage, be administered 7 days, observes corresponding index.

Observation index: observing death condition during medication, daily inleting appetite every to dog, amount of drinking water carry out statistical analysis, to dog The mental status, two just situation carry out perusal, and do itemized record.

Result: by the dog medication anxious Toxicity Observation of 7 days, dead without dog, for dog class diet, drinking-water, the mental status, The observation of two just situations, two groups of dogs are without marked difference；Two groups of dog body weight change values are compared, takes Chinese medicine system of the present invention The experimental group dog of agent, its body weight value added is significantly higher than matched group, and the Chinese medicinal tablet of the present invention increase for dog class body weight is described There are remarkable effect, P ＜ 0.05.Because this medicine not effect on human body, therefore dosage uses own control, i.e. dosage meeting On the basis of convention, exceed well over conventional amount used, be i.e. considered heavy dose of administration.

By above-mentioned experimental verification, Chinese medicinal tablet of the present invention is without obvious toxic-side effects.Related Experimental Study can be carried out.

Experimentation

Sick dog source: the parvovirus infections dog 93 that pet clinic of Qingdao City is medical, to dog age, sex, kind of dog without Requirement, unification is included.

Packet and medication: sign clinical application agreement with dog owner, dog of just diagnosing a disease has during 44 people are ready to use and cures Treatment mode, includes Chinese drug-treated group in, and remaining is western medical treatment method, includes Western medicine group in.

Chinese drug-treated group: this group disease dog uses the Chinese medicinal tablet 1 of the embodiment of the present invention 1 preparation, disease preferable for ordinary circumstance Dog, uses Chinese medicinal tablet levigation, is added in disease dog feed and drinking-water, it is ensured that sick dog reaches for the crude drug intake of Chinese medicine 4g/kg/d, medicine time is multiple dosing, not limiting time；For the sick dog that ordinary circumstance is poor, use stomach tube medication, 0.5 centimetre of cut-off footpath, the thin plastic pipe of long 40 centimetres are as stomach tube.After opening oral cavity, insert stomach tube, extract medicinal liquid with syringe Inject stomach tube.Owing to dog has vomiting habit, after extraction stomach tube after 3～5 minutes, common medicinal liquid spues, must after a few minutes of interval again Gavage once by same method, through twice throwing clothes lose vomiting more, it is ensured that day dosage be 4g/kg/d.Sending out according to this disease Sick rule, treatment cycle is 7 days.

Western medicine group: the sick refined 5-linked serum of dog injection combines love Mao Er (bromisoval procaine), for ordinary circumstance relatively Good sick dog, refined 5-linked serum injection amount is 1ml/kg, 1 times/day, likes that your injection volume of cyclopentadienyl is 2ml/ time, 1 times/day, to diet And drinking-water does not processes；For the sick dog that ordinary circumstance is poor, refined 5-linked serum injection amount is 2ml/kg, 1 times/day, likes cyclopentadienyl Your injection volume is 2ml/ time, 2 times/day, does not processes diet and drinking-water；According to the occurrence regularity of this disease, treatment cycle is 7 My god.

Observation index: after administration, observe dog diet, drink water, vomit, two just situations, observe the mental status of dog simultaneously.Right In dying of illness, dog is analysed, and observes the change of each internal organs.

Result:

Sick dog treatment situation

Table 1 sick dog treatment situation

Group	N	Recovery from illness	Effectively	Die of illness	Cure rate	Mortality rate
							Treatment group	44	22	17	5	50.00%^*	11.36%^*
Matched group	49	9	19	21	18.37%	42.86%

Compare with matched group,^*P ＜ 0.05

By sick dog is treated the comparison of situation, the cure rate of Chinese medicinal tablet of the present invention is significantly higher than western medicine group P ＜ 0.05, mortality rate is substantially less than matched group P ＜ 0.05 simultaneously.

Sick dog ordinary circumstance

For dead sick dog, carry out ordinary circumstance observation, observe dog diet, drink water, vomit, two just situations, see simultaneously Examine the mental status of dog.

The ordinary circumstance of the not dead sick dog of table 2

Group	N	Diet increases	Drinking-water increases	Vomiting reduces	Two is the most normal	Mental status amelioration
							Chinese drug-treated group	39	33	36	29^*	30^*	36^*
Doctor trained in Western medicine group	28	24	25	13	16	22

Compare with doctor trained in Western medicine group,^*P ＜ 0.05

By the dog that do not dies of illness is carried out ordinary circumstance observation, improve in vomiting, two just the changing of condition improved and mental status On Shan, treatment group is significantly better than matched group, P ＜ 0.05.

From the above it can be seen that Chinese medicinal tablet of the present invention has for the sick dog of Canine parvovirus infection well treats work With, reduce sick dog case fatality rate, improve the ordinary circumstance of sick dog simultaneously.There is good using value.

Experimentation

Sick dog source: certain dog base parvovirus infections dog 83 of Dezhou, Shandong.

Clinical manifestation: primary disease is general without advanced symptoms, many sudden onset.Mainly show as serious gastroenteritis haemorrhagica disease Shape, i.e. vomits, suffers from diarrhoea, arranges band bloody stool and be just dehydrated with body, and apparent altitude is depressed simultaneously, and appetite is useless absolutely, astasia, body temperature liter Up to 40 DEG C～41 DEG C, but the body temperature that general adult dogs has is the highest, suffers from diarrhoea the most sustainable about one week.Leukocyte count is obvious Reduce, have to drop to 3000/mm3 such as the following.

Packet is administered: disease dog is divided into 4 groups, is invention group 21 respectively, comparative example 1 group 21, comparative example 2 groups 21, Western medicine group 20.

Invention group: this group disease dog uses the Chinese medicinal tablet 1 of the embodiment of the present invention 1 preparation, disease preferable for ordinary circumstance Dog, uses Chinese medicinal tablet levigation, is added in disease dog feed and drinking-water, it is ensured that sick dog reaches 4g/kg/ for the intake of Chinese medicine D, medicine time is multiple dosing, not limiting time；For the sick dog that ordinary circumstance is poor, use stomach tube medication, cut-off footpath 0.5 centimetre, the thin plastic pipe of long 40 centimetres is as stomach tube.After opening oral cavity, insert stomach tube, inject stomach with syringe extraction medicinal liquid Pipe.Owing to dog has vomiting habit, after extraction stomach tube after 3～5 minutes, common medicinal liquid spues, must be again with equally after a few minutes of interval Method gavage once, through twice throwing clothes lose vomiting more, it is ensured that day dosage be 4g/kg/d.According to the occurrence regularity of this disease, Treatment cycle is 7 days.

Comparative example 1 group: this group disease dog uses the Chinese medicinal tablet 2 of comparative example 1 of the present invention preparation, preferable for ordinary circumstance Sick dog, uses Chinese medicinal tablet levigation, is added in disease dog feed and drinking-water, it is ensured that sick dog reaches 4g/ for the intake of Chinese medicine Kg/d, medicine time is multiple dosing, not limiting time；For the sick dog that ordinary circumstance is poor, use stomach tube medication, cut-off 0.5 centimetre of footpath, the thin plastic pipe of long 40 centimetres are as stomach tube.After opening oral cavity, insert stomach tube, inject with syringe extraction medicinal liquid Stomach tube.Owing to dog has vomiting habit, after extraction stomach tube after 3～5 minutes, common medicinal liquid spues, must be again with same after a few minutes of interval The method of sample gavages once, through twice throwing clothes lose vomiting more, it is ensured that day dosage be 4g/kg/d.Morbidity rule according to this disease Rule, treatment cycle is 7 days.

Comparative example 2 groups: this group disease dog uses the Chinese medicinal tablet 3 of comparative example 2 of the present invention preparation, preferable for ordinary circumstance Sick dog, uses Chinese medicinal tablet levigation, is added in disease dog feed and drinking-water, it is ensured that sick dog reaches 4g/ for the intake of Chinese medicine Kg/d, medicine time is multiple dosing, not limiting time；For the sick dog that ordinary circumstance is poor, use stomach tube medication, cut-off 0.5 centimetre of footpath, the thin plastic pipe of long 40 centimetres are as stomach tube.After opening oral cavity, insert stomach tube, inject with syringe extraction medicinal liquid Stomach tube.Owing to dog has vomiting habit, after extraction stomach tube after 3～5 minutes, common medicinal liquid spues, must be again with same after a few minutes of interval The method of sample gavages once, through twice throwing clothes lose vomiting more, it is ensured that day dosage be 4g/kg/d.Morbidity rule according to this disease Rule, treatment cycle is 7 days.

Result:

Sick dog treatment situation

Table 3 sick dog treatment situation

Group	N	Recovery from illness	Effectively	Die of illness	Cure rate	Mortality rate
							Invention group	21	11	9	1	52.38%^*	4.8%^*
Comparative example 1 group	21	4	6	11	19.05%^#	52.38%^#
							Comparative example 2 groups	21	4	13	4	19.05%^#	19.05%^*#
Western medicine group	20	5	6	9	25.00%	45.00%

Compare with Western medicine group,^*P ＜ 0.05；Compare with invention group,^#P ＜ 0.05

By sick dog is treated the comparison of situation, the cure rate of Chinese medicinal tablet of the present invention is significantly higher than Western medicine group and compares Example group, P ＜ 0.05, mortality rate is substantially less than matched group and comparative example group, P ＜ 0.05 simultaneously.Invention goes Rhizoma Coptidis group mortality rate to show Write and increase, when illustrate that the consumption of Rhizoma Coptidis and charred Radix Sanguisorbae is very little, understand the therapeutic effect of appreciable impact parvovirus, the effect of antiviral Weaken.

Sick dog ordinary circumstance

The ordinary circumstance of the not dead sick dog of table 4

Compare with Western medicine group,^*P ＜ 0.05；Compare with invention group,^#P ＜ 0.05,^##P ＜ 0.01

By the dog that do not dies of illness is carried out ordinary circumstance observation, improve in vomiting, two just the changing of condition improved and mental status On Shan, treatment group is significantly better than matched group, P ＜ 0.05.Compare with invention group, when Chinese medicine preparation humus flava usta consumption of the present invention very little Time, diet, drink water, vomit, two just situation and mental status all have notable significant difference, P ＜ 0.05 or P ＜ 0.01.

Chinese medicinal tablet of the present invention has good therapeutical effect for the sick dog of Canine parvovirus infection, reduces sick dog disease dead Rate, improves the ordinary circumstance of sick dog simultaneously.There is good using value.And its prescription medicine need to keep former side's commercial weight, otherwise Its drug effect goes down.After being evaluated by security related, Chinese medicine preparation of the present invention will be applicable to clinical application.

All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement limiting other forms And/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar execution feelings Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims

1. one kind for treating the medicine of Canine Parvovirus, it is characterised in that: crude drug include charred Radix Sanguisorbae, charred Flos Sophorae, Flos Lonicerae, Rhizoma Coptidis, Cortex Phellodendri, Semen Plantaginis, the Radix Pulsatillae, Herba Portulacae, Herba Agrimoniae, Halloysitum Rubrum, Rhizoma Corydalis, Poria, Monas cuspurpureus Went, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), grey Art, humus flava usta, Radix Bupleuri, Rhizoma Cimicifugae and Radix Puerariae.

2. the medicine for treating Canine Parvovirus as claimed in claim 1, it is characterised in that: the weight portion of each crude drug divides Wei charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 8 parts～12 parts, Flos Lonicerae 13 parts～17 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 10 parts～14 parts, Herba Plantaginis Son 13 parts～17 parts, the Radix Pulsatillae 13 parts～17 parts, Herba Portulacae 28 parts～32 parts, Herba Agrimoniae 28 parts～32 parts, Halloysitum Rubrum 8 parts～12 Part, Rhizoma Corydalis 28 parts～32 parts, 58 parts～62 parts of Poria, 18 parts～22 parts of Monas cuspurpureus Went, Radix Codonopsis 38 parts～42 parts, Rhizoma Atractylodis Macrocephalae (parched) 38 parts～ 42 parts, Rhizoma Atractylodis 18 parts～22 parts, humus flava usta 40 parts, Radix Bupleuri 6 parts～10 parts, Rhizoma Cimicifugae 6 parts～10 parts, Radix Puerariae 28 parts～32 parts.

3. the medicine for treating Canine Parvovirus as claimed in claim 1 or 2, it is characterised in that: the weight of each crude drug Part is respectively charred Radix Sanguisorbae 20 parts, charred Flos Sophorae 10 parts, Flos Lonicerae 15 parts, Rhizoma Coptidis 20 parts, Cortex Phellodendri 12 parts, Semen Plantaginis 15 parts, the Radix Pulsatillae 15 parts, Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Halloysitum Rubrum 10 parts, Rhizoma Corydalis 30 parts, 60 parts of Poria, 20 parts of Monas cuspurpureus Went, Radix Codonopsis 40 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Rhizoma Atractylodis 20 parts, humus flava usta 40 parts, Radix Bupleuri 8 parts, Rhizoma Cimicifugae 8 parts, Radix Puerariae 30 parts.

4. the medicine for treating Canine Parvovirus as described in claims 1 to 3, it is characterised in that: described medicine is prepared as Tablet.

5. the preparation method of the medicine for treating Canine Parvovirus described in Claims 1-4, it is characterised in that: work as preparation During piece agent, specifically,

3rd step, the effective extract component of medicine that second step obtains is mixed homogeneously according to the mass ratio of 3: 2 with starch, adds Excipients magnesium stearate, the addition of magnesium stearate is the 5% of starch and effective extract component mixing quality sum, is pressed into Sheet, it is thus achieved that tablet.

6. the preparation method of the medicine for treating Canine Parvovirus as claimed in claim 5, it is characterised in that: described first Step is specially further and is pulverized respectively by each crude drug, mixes, and adds the water boil of mixture quality 10 times, and maintenance 2 is little Time, filtering, filtering residue adds the water boil of mixture quality 6 times again, maintains 1 hour, filters, and twice filtrate mixes, for the Two steps concentrate.

7. the preparation method of the medicine for treating Canine Parvovirus as described in claim 5 or 6, it is characterised in that: described Second step is that the hybrid filtering liquid first step obtained concentrates further, it is thus achieved that the mastic of 60 DEG C of relative densities 1.25, for the 3rd Step uses.