CN101721336A - Gargle with drinking safety and preparation method thereof - Google Patents
Gargle with drinking safety and preparation method thereof Download PDFInfo
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- CN101721336A CN101721336A CN200810201816A CN200810201816A CN101721336A CN 101721336 A CN101721336 A CN 101721336A CN 200810201816 A CN200810201816 A CN 200810201816A CN 200810201816 A CN200810201816 A CN 200810201816A CN 101721336 A CN101721336 A CN 101721336A
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Abstract
The invention relates to gargle with the drinking safety, comprising the following components by weight percent: 0.1-0.5 percent of tea polyphenols, 0.05-0.3 percent of magnolol, 0.05-0.3 percent of paeonol, 0.01-0.1 percent of phytic acid dodecasodium salt, 0.5-3 percent of glycyrrhizic acid, 1-5 percent of ethanol, 0.05-0.5 percent of mentha haplocalyx, 0.001-0.01 percent of essence, 0.05-0.2 percent of propylgallate, 0.01-0.1 percent of sodium cyclamate, 0.05-0.5 percent of macromolecule suspending agent, 0.3-2 percent of surface active agent and the balance of water. A preparation method of the gargle comprises the following steps of: adding tea polyphenols, magnolol, paeonol, propylgallate, mentha haplocalyx and essence into the ethanol according to the content and components, stirring for dissolving to obtain solution A; adding the phytic acid dodecasodium salt, glycyrrhizic acid, sodium cyclamate, macromolecule suspending agent and surface active agent into water, stirring for dissolving to obtain solution B; slowly adding the solution A into the solution B while stirring, and evenly stirring the mixture solution to obtain the gargle. The gargle has clear appearance, is slightly sweet in the mouth feel and ensures fresh breath after use.
Description
Technical field
The present invention relates to dental care products liquid, relate in particular to a kind of collutory and preparation method thereof with drinking safety.
Background technology
Along with people's raising of quality of life, oral cavity cleaning becomes the important component part of daily life.The common method of oral cavity cleaning mainly contains two kinds at present, and a kind of is to brush teeth, and a kind of is to gargle.Brush teeth mainly be confined to get up morning the back and sleep evening before, gargling then has conveniently characteristics.The collutory kind is a lot of in the market, mostly is chemicals greatly, or the compound recipe of chemicals and Chinese herbal medicine.Owing to can keep collutory residual at the deutostoma intracavity of gargling, even gargle can wrongly take when careless and drink in the body, this preparation that contains chemical drugs can have side effects to human body.
Summary of the invention
The present invention is intended to overcome and contains the chemical drugs collutory human body is had the shortcoming of side effect, and a kind of collutory with drinking safety and preparation method thereof is provided.The present invention adopts pure natural plant ingredients, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, drinks in the body even wrongly take, also without any side effects to human body.The present invention has also added natural Herba Menthae simultaneously, and the little suffering of mouthfeel is sweet, can dispel halitosis, and the back breath freshening of gargling is happy refreshing.
A kind of collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus.
Described collutory, described surfactant are nonionic surfactant or anionic surfactant.
Described collutory, described nonionic surfactant are polyoxyethylene sorbitan ester or fatty alcohol-polyoxyethylene ether.
Described collutory, described anionic surfactant are sodium laurylsulfate.
Described collutory, the agent of described macromolecule suspending are one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
A kind of described preparation method with collutory of drinking safety is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
The present invention utilizes the comprehensive function of tea polyphenols, magnolol, paeonol, sodium phytate, glycyrrhizic acid to suppress the periodontal pathogen, suppresses dissolving phosphorus calcium and tooth enamel, prevents and treats dental caries.The present invention adopts pure natural plant ingredients, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, drinks in the body even wrongly take, also without any side effects to human body.The present invention has also added natural Herba Menthae simultaneously, and the little suffering of mouthfeel is sweet, has the halitosis of covering, and the good result of cleaning oral cavity makes breath freshening happy refreshing after gargling.
Particularly:
Tea polyphenols is the general name of catechin in the Folium Camelliae sinensis, flavonoid, phenolic acids and anthocyan chemical compound, has multiple efficacies such as antibacterial, sterilization, antitumor, radioprotective.Studies confirm that certain density tea polyphenols can suppress or reduce the quantity of dental plaque and the adhesion on facing thereof, can obviously reduce dental plaque and periodontal disease incidence rate, the effect with caries prevention.In addition, tea polyphenols has good result to removing the methanthiol stink, can remove smoker's halitosis.Tea polyphenols be used for mouth care have inexpensive, the source is abundant, safe and reliable, do not have advantages such as obvious pigmentation, no cumulative toxicity.
Cortex Magnoliae Officinalis is the QI regulating medicine of using always, and functions such as warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant are arranged, and its effective ingredient is that magnolol has strong inhibitory action to the periodontal pathogen, and the effect of good resistance dental caries is arranged.
Paeonol has analgesia, antiinflammatory, analgesic and suppress allergic effect, is applied in toothpaste, gargarism, dentifrice, the toothache drops, has reducing swelling and alleviating pain, prevents and treats dental caries, covers halitosis, good result such as cleaning oral cavity.
Natural sodium phytate can suppress to dissolve the ability of phosphorus calcium and tooth enamel effectively, has anti-dental caries effect, and as cleaning the teeth except that the additive of speckle, effect is also fairly good, and is effective especially to dispeling dental surface dirts such as smoking patch, black, Huang.
Glycyrrhizic acid is the natural component in the Radix Glycyrrhizae, can suppress oral cavity bacterium, has tonifying the spleen and stomach, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, mediation implication and expectorant effect.
Collutory of the present invention adopts above-mentioned natural plant composition, safety non-toxic, and it is harmless to oral cavity tissue to gargle for a long time, even drink in the body, also without any side effects to human body.Also add natural Herba Menthae in the collutory of the present invention, can dispel halitosis, made breath freshening lasting.
The specific embodiment
Below, in conjunction with specific embodiments, further specify the present invention:
A kind of collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus.
Described collutory, described surfactant are nonionic surfactant or anionic surfactant.
Described collutory, described nonionic surfactant are polyoxyethylene sorbitan ester or fatty alcohol-polyoxyethylene ether.
Described collutory, described anionic surfactant are sodium laurylsulfate.
Described collutory, the agent of described macromolecule suspending are one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
A kind of described preparation method with collutory of drinking safety is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
Embodiment 1
Tea polyphenols 2.5 gram, magnolol 1 gram, paeonol 2 grams, propyl gallate 1 gram, Herba Menthae 0.5 gram, essence 0.01 gram are joined in ethanol 30 grams, stirring and dissolving, A liquid; Sodium phytate 0.5 gram, glycyrrhizic acid 20 grams, cyclamate 0.5 gram, polyvinylpyrrolidone 5 grams, polyoxyethylene 20 sorbitan monooleate 10 grams are joined in water 926.99 grams, stirring and dissolving, B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
Embodiment 2
Tea polyphenols 5 gram, magnolol 0.5 gram, paeonol 1 gram, propyl gallate 0.5 gram, Herba Menthae 0.3 gram, essence 0.05 gram are joined in ethanol 50 grams, stirring and dissolving, A liquid; Sodium phytate 0.2 gram, glycyrrhizic acid 5 grams, cyclamate 1 gram, sodium carboxymethyl cellulose 0.5 gram, sodium laurylsulfate 15 grams are joined in water 920.95 grams, stirring and dissolving, B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
Embodiment 3
Tea polyphenols 1 gram, magnolol 2 grams, paeonol 1.5 grams, propyl gallate 2 grams, Herba Menthae 0.5 gram, essence 0.1 gram are joined in ethanol 15 grams, stirring and dissolving, A liquid; Sodium phytate 1 gram, glycyrrhizic acid 10 grams, cyclamate 0.3 gram, hydroxyethyl-cellulose 1 gram, fatty alcohol-polyoxyethylene ether (AEO9) 5 grams are joined in water 960.6 grams, stirring and dissolving, B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
Carry out bacteriostatic test according to GB15979-2002 " disposable use hygienic article sanitary standard appendix C ", get the various embodiments described above collutory effect 2min, to colibacillary average bacteriostasis rate is 100%, is 100% to the average bacteriostasis rate of staphylococcus aureus.
Carry out safety testing according to " foodsafety assessment process and method ", get the various embodiments described above collutory and give mouse stomach, each dosage is that every 20g body weight is irritated stomach 1.0ml, irritates stomach three times in one day, observes continuously 14 days.Any Deviant Behavior did not appear in mice after the result irritated stomach, did not more have dead routine number, and it is all no abnormal to observe organs such as the heart, liver, spleen, lung, kidney after dissecting.Show this collutory safety non-toxic.
In sum, rinse product outward appearance of the present invention is as clear as crystal, and the little suffering of mouthfeel is sweet, and the natural Herba Menthae taste of tool can be dispeled halitosis after gargling, and makes breath freshening happy refreshing.Collutory bacteriostasis of the present invention is strong, is 100% to the average bacteriostasis rate of escherichia coli and staphylococcus aureus, can effectively suppress oral cavity bacterium, safeguards the oral cavity sanitation and hygiene.Collutory safety non-toxic of the present invention, it is harmless to oral cavity tissue to gargle for a long time, even drink in the body, also without any side effects to human body.
Claims (6)
1. collutory with drinking safety, it comprises each component of following each percetage by weight:
Tea polyphenols, 0.1-0.5;
Magnolol, 0.05-0.3;
Paeonol, 0.05-0.3;
Sodium phytate, 0.01-0.1;
Glycyrrhizic acid, 0.5-3;
Ethanol, 1-5;
Herba Menthae, 0.05-0.5;
Essence, 0.001-0.01;
Propyl gallate, 0.05-0.2;
Cyclamate, 0.01-0.1;
The agent of macromolecule suspending, 0.05-0.5;
Surfactant, 0.3-2;
Water, surplus.
2. collutory according to claim 1 is characterized in that, described surfactant is nonionic surfactant or anionic surfactant.
3. collutory according to claim 2 is characterized in that, described nonionic surfactant is polyoxyethylene sorbitan ester or fatty alcohol-polyoxyethylene ether.
4. collutory according to claim 2 is characterized in that, described anionic surfactant is a sodium laurylsulfate.
5. collutory according to claim 1 is characterized in that, the agent of described macromolecule suspending is one or more in polyvinylpyrrolidone, hydroxyethyl-cellulose or the sodium carboxymethyl cellulose.
6. the preparation method according to the described arbitrary collutory of claim 1 to 5 is: by described content and component, tea polyphenols, magnolol, paeonol, propyl gallate, Herba Menthae, essence are joined in the ethanol, stirring and dissolving gets A liquid; Sodium phytate, glycyrrhizic acid, cyclamate, the agent of macromolecule suspending, surfactant are added to the water, and stirring and dissolving gets B liquid; When stirring, A liquid is slowly added in the B liquid, stir, promptly get described collutory.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008102018165A CN101721336B (en) | 2008-10-27 | 2008-10-27 | Gargle with drinking safety and preparation method thereof |
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| CN2008102018165A CN101721336B (en) | 2008-10-27 | 2008-10-27 | Gargle with drinking safety and preparation method thereof |
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| CN101721336A true CN101721336A (en) | 2010-06-09 |
| CN101721336B CN101721336B (en) | 2013-03-06 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013089719A1 (en) * | 2011-12-15 | 2013-06-20 | Colgate-Palmolive Company | Solubilized magnolol analogs |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| WO2017206015A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Long-lasting antibacterial and tooth protection gargle |
| CN112370477A (en) * | 2020-11-03 | 2021-02-19 | 广东启美生物科技有限公司 | Antibacterial oral preparation for refreshing breath, strengthening teeth and protecting gingiva and equipment thereof |
| CN114796260A (en) * | 2022-06-28 | 2022-07-29 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
-
2008
- 2008-10-27 CN CN2008102018165A patent/CN101721336B/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013089719A1 (en) * | 2011-12-15 | 2013-06-20 | Colgate-Palmolive Company | Solubilized magnolol analogs |
| CN104023698A (en) * | 2011-12-15 | 2014-09-03 | 高露洁-棕榄公司 | Solubilized magnolol analogs |
| US9414587B2 (en) | 2011-12-15 | 2016-08-16 | Cologne-Palmolive Company | Solubilized magnolol analogs |
| CN104023698B (en) * | 2011-12-15 | 2016-10-05 | 高露洁-棕榄公司 | The magnolol analog dissolved |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
| WO2017206015A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Long-lasting antibacterial and tooth protection gargle |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN112370477A (en) * | 2020-11-03 | 2021-02-19 | 广东启美生物科技有限公司 | Antibacterial oral preparation for refreshing breath, strengthening teeth and protecting gingiva and equipment thereof |
| CN114796260A (en) * | 2022-06-28 | 2022-07-29 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
| CN114796260B (en) * | 2022-06-28 | 2022-09-27 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
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| CN101721336B (en) | 2013-03-06 |
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