CN104739685A - Gargle containing chlorhexidine gluconate and preparation method thereof - Google Patents

Abstract

The invention relates to articles for oral hygiene, especially to a gargle containing chlorhexidine gluconate and a preparation method thereof. The gargle containing chlorhexidine gluconate comprises the following components by weight: 0.1 to 1.0% of sodium dodecyl benzene sulfonate, 0.05 to 0.2% of chlorhexidine gluconate, 0.1 to 0.8% of honeysuckle flower extract, 0.1 to 0.5% of tea extract, 0.1 to 0.5% of gentrin knotweed extract, 0.2 to 1.0% of isatis root extract, 5 to 15% of edible alcohol, 0.02 to 0.1% of mint, 0.02 to 0.2% of sodium fluoride and 0.5 to 2% of xylitol, with the balance being water. The preparation method comprises the following steps: dissolving sodium dodecyl benzene sulfonate in drinking water, then successively adding and dissolving the tea extract, the gentrin knotweed extract, the isatis root extract and sodium fluoride, and carrying out full stirring so as to obtain a liquid B; and adding a liquid A into the liquid B under stirring, fully mixing the liquid A with the liquid B, then adding chlorhexidine gluconate and xylitol, carrying out uniform mixing under stirring, and carrying out filling after standing for 12 h. The gargle provided by the invention feels comfortable in mouth when in use and enables the oral cavity to maintain a good state for a long period of time after usage of the gargle.

Description

A kind of collutory containing chlorhexidine gluconate and compound method thereof

Technical field

The present invention relates to dental care product, particularly relate to a kind of hibitane collutory and preparation method thereof.

Background technology

At present, the rinse product both at home and abroad for oral hygiene is a lot, substantially can be divided into the compound and Western medicine Compositional type of Chinese medicine by type.Cleaning oral cavity foreign body can be played, suppress and kill the effect of oral cavity bacterium.But ubiquity mouthfeel is poor, rear residual abnormal smells from the patient difficulty is used to remove, after a procedure the shortcoming of obvious sensation oral environment discomfort in section for a long time.Cause the biggest problem that collutory is promoted the use of.Therefore, preparation one has good effectiveness simultaneously comfortable taste again, and the collutory easily accepted for user becomes popular and one of to study.

Summary of the invention

The present invention is intended to solve the problem, and provides a kind of collutory containing chlorhexidine gluconate and compound method thereof.Comfortable taste when the present invention uses, after use, in the long duration, feel good in oral cavity.

For solving the problem, a kind of collutory containing chlorhexidine gluconate of the present invention, it comprises the component of following weight percents:

Dodecylbenzene sodium sulfonate: 0.1%-1%

Chlorhexidine gluconate: 0.05%-0.2%

Flos Lonicerae extract: 0.05%-0.8%

Folium Camelliae sinensis extract: tea polyphenols 0.1%-0.5%

Edible ethanol: 5%---15%

Herba Menthae: 0.02%-0.1%

Sodium fluoride: 0.02%-0.2%

Xylitol: 0.5%-2%

Drinking water: surplus.

The preparation method of described a kind of collutory containing chlorhexidine gluconate, it comprises: according to described ratio

Add Flos Lonicerae extract after Herba Menthae being dissolved in edible ethanol and stir evenly to obtain A liquid;

Add Folium Camelliae sinensis extract after dodecylbenzene sodium sulfonate being dissolved in drinking water successively, sodium fluoride dissolves and fully stirs to obtain B liquid;

After A liquid being joined while stirring in B liquid fully mixing, adding Fructus Vitis viniferae pickling must calm and peaceful xylitol, stirs evenly, leaves standstill fill after 12 hours.

The present invention adopts wide-spectrum bactericide chlorhexidine gluconate to be major antibacterial agent, effectively can dispel various common oral antibacterial, in the oral cavity can with saliva protein binding, reduce the bacterial plaque generation probability of tooth.And sodium fluoride is a kind of effective auti-cariosity material of generally acknowledging, it is combined with chlorhexidine gluconate and can produces synergism, more effectively suppresses tooth Mycoderma to be grown, reaches the object of prevention and therapy periodontal disease and dental caries.

The present invention adopts Rhizoma Polygoni Cuspidati extract and Radix Isatidis extract as Chinese medicine bactericide, Rhizoma Polygoni Cuspidati and Radix Isatidis can have remarkable inhibitory action to common pathogenic bacteria such as staphylococcus aureus, A type or group B streptococcus and escherichia coli etc., Flos Lonicerae has antipyretic and antidote functions, three share has synergism, after chlorhexidine gluconate effect, effectively can safeguard oral cavity environmental health anti-bacteria regeneration lastingly.

In the present invention, chlorhexidine gluconate is combined with Flos Lonicerae, Rhizoma Polygoni Cuspidati and Radix Isatidis, can accomplish than the faster kill harmful antibacterial of market other types collutory, the regeneration suppressing noxious bacteria more lastingly.Reducing collutory when gargling, in the time of staying in the mouth, makes this collutory use more convenient, more comfortable.

Adopt Flos Lonicerae and Folium Camelliae sinensis extract to be oral environment protective agent in the present invention, Flos Lonicerae abnormal smells from the patient is comfortable, Folium Camelliae sinensis comfortable taste simultaneously, and effectively can strengthen the faint scent of Flos Lonicerae.The two coordinates ethanol can meet the mouthfeel demand of most of crowd very well.

In the present invention, consider the problems such as the comfortable taste of user, use the surfactant (dodecylbenzene sodium sulfonate) of small amount, with the addition of a certain amount of xylitol simultaneously, good mouthfeel when making to use, using does not have sense of discomfort substantially afterwards.

Detailed description of the invention

Below, in conjunction with specific embodiments, the present invention is further illustrated:

A kind of collutory containing chlorhexidine gluconate of the present invention, it comprises the component of following weight percents:

Dodecylbenzene sodium sulfonate: 0.1%-1%

Chlorhexidine gluconate: 0.05%-0.2%

Flos Lonicerae extract: 0.05%-0.8%

Folium Camelliae sinensis extract: tea polyphenols 0.1%-0.5%

Edible ethanol: 5%---15%

Herba Menthae: 0.02%-0.1%

Sodium fluoride: 0.02%-0.2%

Xylitol: 0.5%-2%

Drinking water: surplus.

Embodiment 1: preparation 500KG collutory: add Flos Lonicerae extract 0.5KG after 0.2kg Herba Menthae is dissolved in 55kg edible ethanol and fully stir evenly; Obtain A liquid;

4KG dodecylbenzene sodium sulfonate is dissolved in 400KG drinking water and adds 1.5KG Folium Camelliae sinensis extract, 1.0KG Rhizoma Polygoni Cuspidati extract, 1.0KG Radix Isatidis extract and 0.3KG sodium fluoride successively and fully stir evenly to obtain B liquid;

A is joined in B liquid while stirring.Add 0.5KG chlorhexidine gluconate after abundant mixing, 5KG xylitol fully stirs, supply excess water and stir evenly; Put fill after 12 hours.

Embodiment 2: preparation 500KG collutory: add Flos Lonicerae extract 1KG after 0.1kg Herba Menthae is dissolved in 30kg edible ethanol and fully stir evenly; Obtain A liquid;

2KG dodecylbenzene sodium sulfonate is dissolved in 400KG drinking water to add successively in 2KG Folium Camelliae sinensis extract, 1.5KG Rhizoma Polygoni Cuspidati extract, 2.0KG Radix Isatidis extract and 0.15KG sodium fluoride and fully stirs evenly to obtain B liquid;

A is joined in B liquid while stirring.Add 0.4KG chlorhexidine gluconate after abundant mixing, 7KG xylitol fully stirs, supply excess water and stir evenly.Leave standstill fill after 12 hours.

Result of use

Seek 36 conventional test persons, be divided into 3 groups, to the collutory in embodiment 1, embodiment 2 formula and on the market collutory test.After experimenter rises with the sun every day and three after the meal use specify collutory, continue 3 days.Get oral fluid after each use and carry out bacterial detection removing situation.

Separately seek 80 experimenters to the collutory in embodiment 1, embodiment 2 formula and on the market collutory carry out comfortable taste test.Use collutory in embodiment 1, embodiment 2 formula and collutory on the market at random in experimenter 3 days, when recording mouth uses and use the oral cavity comfortableness of latter hour.

In experiment, bacteria clearance meansigma methods represents, during use, after one hour, oral cavity comfort level rate of good is represented by table 1 with use:

Table 1

	Noxious bacteria clearance rate	Oral cavity comfort level during use	A h oral comfort level after using
				Embodiment 1	98%	97%	100%
Embodiment 2	94%	100%	100%
				Matched group	46%	51%	82%

Claims (2)

1., containing a collutory for chlorhexidine gluconate, it is characterized in that, it comprises the component of following weight percents:

Dodecylbenzene sodium sulfonate: 0.1%-1.0%;

Chlorhexidine gluconate: 0.05%-0.2%;

Flos Lonicerae extract: 0.1%-0.8%;

Folium Camelliae sinensis extract: tea polyphenols, 0.1%-0.5%;

Rhizoma Polygoni Cuspidati extract: 0.1%-0.5%;

Radix Isatidis extract: 0.2%-1.0%;

Edible ethanol: 5%---15%;

Herba Menthae: 0.02%-0.1%;

Sodium fluoride: 0.02%-0.2%;

Xylitol: 0.5%-2%;

Drinking water: surplus.

2. a preparation method for a kind of collutory containing chlorhexidine gluconate according to claim 1, it is characterized in that, it comprises: according to described ratio

Add Flos Lonicerae extract after Herba Menthae being dissolved in edible ethanol and stir evenly to obtain A liquid;

Add Folium Camelliae sinensis extract, Rhizoma Polygoni Cuspidati extract, Radix Isatidis extract and sodium fluoride after dodecylbenzene sodium sulfonate being dissolved in drinking water successively dissolve and fully stir to obtain B liquid;

After A liquid being joined while stirring in B liquid fully mixing, adding Fructus Vitis viniferae pickling must calm and peaceful xylitol, stirs evenly, leaves standstill fill after 12 hours.