CN105310960A - Novel polysaccharide antibacterial mouthwash and preparation method thereof - Google Patents
Novel polysaccharide antibacterial mouthwash and preparation method thereof Download PDFInfo
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- CN105310960A CN105310960A CN201510731042.7A CN201510731042A CN105310960A CN 105310960 A CN105310960 A CN 105310960A CN 201510731042 A CN201510731042 A CN 201510731042A CN 105310960 A CN105310960 A CN 105310960A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention discloses a novel polysaccharide antibacterial mouthwash and a preparation method thereof. The novel polysaccharide antibacterial mouthwash comprises the active ingredients of carboxymethyl chitosan and propolis and further comprises a Chinese herbal medicine concentrate, sodium alginate, oleum menthae, a pH modifier, ethanol and purified water. The preparation method comprises the following steps: quantitatively adding carboxymethyl chitosan and a propolis and ethanol solution, and heating for dissolution; after the solution is cooled down, adding the Chinese herbal medicine concentrate, sodium alginate, oleum menthae and the pH modifier, supplementing purified water to obtain the total amount, and obtaining the novel polysaccharide antibacterial mouthwash after measuring the pH value. The novel polysaccharide antibacterial mouthwash has the effects of cleaning the oral cavity and resisting bacteria to protect teeth, meanwhile, reduces the allergy risk caused by propolis, has a very unique Chinese herbal medicine fragrance, is added with no synthetic essences, is safer and more healthy, is simple in preparation method, low in cost, lasting and effective in antibacterial effect, free from toxic and side effects on a human body and comfortable in taste.
Description
Technical field
The invention belongs to medical health product field, particularly a kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof.
Background technology
In recent years; the sickness rate of oral pathology is high; along with the raising of living standards of the people and health perception; the control of oral disease and the protection of tooth more and more important; it is inconvenient to there is use in the mouth care means that traditional employing toothpaste is brushed teeth; cleaning not in time, not thoroughly, have the drawbacks such as wearing and tearing to tooth, is difficult to the oral cavity cleaning requirement meeting people.
Oral disease is a kind of common disease, and main manifestations is the symptoms such as gingivitis, dental plaque, oral ulcer, periodontitis, aphtha of the mouth and tongue, halitosis.After the noxious bacteria that oral disease produces enters into blood, on whole body health generation impact in various degree, can even become the Important cause of disease of some general diseases.Modern medicine study shows, oral disease and hormonal system, cardiovascular system respiratory system etc. of unifying all has close relationship.People also prevent the generation of oral disease for a long time by various oral care product.At present, major product in detergents and cosmetic mouth care can be divided into toothpaste, collutory and flavorants, these products mainly play cleaning teeth, tooth-whitening, removal dental plaque, kill the effects such as oral cavity noxious bacteria, caries prevention, fresh breath, also play certain positive role to the treatment of such as some oral diseases such as various focusing depths represented simultaneously.Some other chewing gum as foodstuff, edible implication cleaning sheet etc. also have preventive effect more or less in addition.
Collutory is as a kind of emerging oral cavity cleaning and nursing product, generally be contained in portable Packaging Bottle, can use at any time, thoroughly overcome mouth care not in time, toothpaste uses inconvenient, the clean drawback such as not thorough, the effect such as its cleaning oral cavity, caries prevention and periodontitis is obviously better than conventional toothpaste, and then very popular in recent years.Before the present invention makes, the existing product such as water-soluble chitosan collutory, tea polyphenols collutory uses clinically, but because self fungistatic effect is single, higher to concentration requirement, or need could arrive fungistatic effect with high concentration ethanol synergism, so that narrow antimicrobial spectrum, result of use is poor, mouthfeel is not good, and patient is difficult to the reasons such as acceptance, and causes being difficult to apply.
Propolis, because have the features such as broad-spectrum antiseptic, anti-mildew change and antiviral, as a kind of natural antibiotics, has been applied in tooth paste product.But, propolis raw material complicated component, easily there is anaphylaxis and can not determine anaphylactogen in the people of allergic constitution, propolis extraction process is not easy supervision in addition, in the actual propolis used, content of beary metal generally exceeds standard, and propolis itself is acidulous material and is rich in estrogen substance, there is certain dissolution to enamel, the calcium stripping in tooth can be caused.Collutory due to its occupation mode different with toothpaste, the ratio toothpaste swallowed into by human body is high, therefore, uses propolis more will focus on formula in collutory, make every effort to play the advantage of propolis and make up propolis shortcoming, making its better effect of performance in rinse product.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of containing natural antibacterial ingredient, not containing compound essence, retentiveness is good, can broad-spectrum antiseptic, durable antibacterial effect is effective, to human non-toxic's side effect, the collutory of comfortable taste; Meanwhile, the present invention also provides a kind of preparation method of described collutory.
Novel polysaccharide antimicrobial mouthwash provided by the invention, its constituent mass percentage composition is:
Carboxymethyl chitosan: 1 ~ 3%
Propolis: 1 ~ 5%
Chinese herbal medicine concentrated solution: 0.5 ~ 1%
Sodium alginate: 0.2 ~ 0.5%
Oleum menthae: 0.01 ~ 0.05%
Acid-base modifier: 0.1 ~ 0.5%
Ethanol: 5 ~ 15%
Surplus is purified water,
Wherein said the concentrated liquid of tradition Chinese medicine is with 10 ~ 15 weight portion Flos Loniceraes, 13 ~ 17 weight portion Flos Chrysanthemi Indicis, 12 ~ 18 weight portion Rhizoma Corydalis, 12 ~ 18 weight portion green tea, 3 ~ 7 weight portion Herba Asaris for crude drug, and every ml that water boiling concentration is made contains the concentrated liquid of tradition Chinese medicine of crude drug 0.5 ~ 1.5mg.
Novel polysaccharide antimicrobial mouthwash as above and preparation method thereof, comprises the steps:
(1) directly joined in dissolution kettle by carboxymethyl chitosan, dissolve by purified water, open calorstat, mechanical agitation at temperature is T=40 ~ 50 DEG C, until carboxymethyl chitosan all dissolves;
(2) directly join in dissolution kettle after propolis being dissolved with ethanol, ensure that solution is uniform state;
(3) be 5.0 ~ 6.5 with the pH value of acid-base modifier regulating step (2) gained solution;
(4) in step (3) gained solution, add Chinese herbal medicine concentrated solution, sodium alginate, Oleum menthae, regulate temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) step (4) gained solution is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
Further, described acid-base modifier is one or both in sodium hexameta phosphate, tetrasodium pyrophosphate.
Beneficial effect of the present invention is as follows:
1, natural component, broad-spectrum antiseptic: carboxymethyl chitosan of the present invention belongs to natural antimicrobial substance, raw material is extensive, and structure is clear and definite, with low cost.Chitosan is the many a kind of natural polysaccharide of Recent study, there is unique molecular structure, be unique a large amount of basic amine group polysaccharide existed in natural polysaccharide, there is antibacterial effect, have been found that Chitosan-phospholipid complex has the effect improving Chinese medicine preparation stability in addition.Propolis not only containing abundant vitamin and multiple nutrients trace element, and has obvious antibacterial sterilization efficacy, and it can suppress and kill various bacteria, virus etc.The present invention uses carboxymethyl chitosan more soluble in water and propolis as main component, has synergism, can strengthen antibiotic effect, have excellent fungistatic effect relative to other single chitosan class collutory.
2, safe and reliable, breath freshening: the present invention adds the Chinese medicine extraction liquid carrying out compatibility with components such as Flos Lonicerae, Flos Chrysanthemi Indici, Rhizoma Corydalis, Herba Asari, green tea, particularly Herba Asari, it has antihistamine effect, significant relexation is had to tracheal smooth muscle, add on a small quantity in the collutory of propolis-containing after above Chinese medicine extraction, substantially increase the safety using propolis as the collutory of component." but being medicine three points of poison ", Chinese medicine is thought Herba Asari is slightly poisonous, therefore can not add separately in rinse product, can not add too much, the compatibility of Chinese medicine extraction liquid provided by the invention and addition effectively can solve the problem of Herba Asari toxicity, make rinse product safe and reliable, form a kind of very unique Chinese herbal medicine fragrance simultaneously, as the fragrance of collutory, thus do not add any compound essence, more safety and Health.
3, preparation method simple, with low cost, be easy to carry: gargle preparation method of the present invention is simple, with low cost, and durable antibacterial effect is effective, and to human non-toxic's side effect, comfortable taste, is easy to carry, and suits large area to popularize and applies.
Detailed description of the invention
Further illustrate technical scheme of the present invention below by way of specific embodiment, but technical scheme of the present invention is not limited with embodiment.
Embodiment 1:
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process is:
(1) directly joined in dissolution kettle by the carboxymethyl chitosan of 1%, dissolve by purified water, open calorstat, mechanical agitation at temperature is T=40 ~ 50 DEG C, until carboxymethyl chitosan all dissolves;
(2) directly join in dissolution kettle after the propolis of 1% being dissolved with ethanol, ensure that solution is uniform state;
(3) be 5.0 ~ 6.5 with sodium hexameta phosphate as the pH value of acid-base modifier regulating step (2) gained solution;
(4) in step (3) gained solution, add Chinese herbal medicine concentrated solution, 0.2% sodium alginate, 0.01% Oleum menthae of 0.5%, regulate temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) step (4) gained solution is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
Chinese herbal medicine concentrated solution described in above-mentioned preparation method is extracting honeysuckle 15 grams, Flos Chrysanthemi Indici 15 grams, Rhizoma Corydalis 15 grams, green tea 15 grams, Herba Asari 5 grams, adds in 1.5 liters of purified water, first decoct 20 minutes at 180 DEG C, then decoct 40 minutes in 110 DEG C, filter and obtain filtrate about 500 milliliters.Add 1.5 liters of deionized waters in medicinal residues again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes, filter and obtain filtrate about 300 milliliters.Merge twice filtrate, 110 DEG C are concentrated into 120 milliliters, make the concentrated liquid of tradition Chinese medicine, and every ml is containing crude drug 0.5 ~ 1.5mg.
Embodiment 2:
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process is:
(1) directly joined in dissolution kettle by the carboxymethyl chitosan of 2%, dissolve by purified water, open calorstat, mechanical agitation at temperature is T=40 ~ 50 DEG C, until carboxymethyl chitosan all dissolves;
(2) directly join in dissolution kettle after the propolis of 3% being dissolved with ethanol, ensure that solution is uniform state;
(3) be 5.0 ~ 6.5 with sodium hexameta phosphate as the pH value of acid-base modifier regulating step (2) gained solution;
(4) in step (3) gained solution, add Chinese herbal medicine concentrated solution, 0.2% sodium alginate, 0.01% Oleum menthae of 0.5%, regulate temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) step (4) gained solution is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
Chinese herbal medicine concentrated solution described in above-mentioned preparation method is extracting honeysuckle 15 grams, Flos Chrysanthemi Indici 15 grams, Rhizoma Corydalis 15 grams, green tea 15 grams, Herba Asari 5 grams, adds in 1.5 liters of purified water, first decoct 20 minutes at 180 DEG C, then decoct 40 minutes in 110 DEG C, filter and obtain filtrate about 500 milliliters.Add 1.5 liters of deionized waters in medicinal residues again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes, filter and obtain filtrate about 300 milliliters.Merge twice filtrate, 110 DEG C are concentrated into 120 milliliters, make the concentrated liquid of tradition Chinese medicine, and every ml is containing crude drug 0.5 ~ 1.5mg.
Embodiment 3
A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof, its preparation process is:
(1) directly joined in dissolution kettle by the carboxymethyl chitosan of 3%, dissolve by purified water, open calorstat, mechanical agitation at temperature is T=40 ~ 50 DEG C, until carboxymethyl chitosan all dissolves;
(2) directly join in dissolution kettle after the propolis of 5% being dissolved with ethanol, ensure that solution is uniform state;
(3) be 5.0 ~ 6.5 with tetrasodium pyrophosphate as the pH value of acid-base modifier regulating step (2) gained solution;
(4) in step (3) gained solution, add Chinese herbal medicine concentrated solution, 0.5% sodium alginate, 0.03% Oleum menthae of 1%, regulate temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) step (4) gained solution is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
Chinese herbal medicine concentrated solution described in above-mentioned preparation method is extracting honeysuckle 15 grams, Flos Chrysanthemi Indici 15 grams, Rhizoma Corydalis 15 grams, green tea 15 grams, Herba Asari 5 grams, adds in 1.5 liters of purified water, first decoct 20 minutes at 180 DEG C, then decoct 40 minutes in 110 DEG C, filter and obtain filtrate about 500 milliliters.Add 1.5 liters of deionized waters in medicinal residues again, 180 DEG C decoct 15 minutes, and 110 DEG C decoct 30 minutes, filter and obtain filtrate about 300 milliliters.Merge twice filtrate, 110 DEG C are concentrated into 120 milliliters, make the concentrated liquid of tradition Chinese medicine, and every ml is containing crude drug 0.5 ~ 1.5mg.
Collutory prepared by the present invention is brown liquid, lightly seasoned sweet.Preferably at ordinary times sooner or later to use between two meal, during use, getting collutory 15 ~ 20ml rinsing the mouth 1 ~ 2 minute in mouth, spue after gargling and can receive tasty and refreshing effect.Clinical test results shows: embodiment product significantly can reduce the bacterial population in oral cavity in Clinical practice process, the growth of anti-bacteria, test forward and backward subject oral cavity bacteria in crevicular fluid and cultivate counting statistical analysis P<0.0001, have significant difference; Clinical experiment 137 example, irritated and malaise symptoms incidence rate is 0, and to the overall efficiency 95.20% of Bad Breath Treatment, before and after treatment, halitosis scoring has significant difference; Total effective rate treatment being improved to oral ulcer is 96.18%, and experimenter uses the overall satisfaction rate of embodiment product to reach 97.88%.Antimicrobial mouthwash prepared by the results show can kill the pathogenic bacterium causing periodontitis, gingivitis, oral ulcer, dental plaque, dental hemorrhage, halitosis fast, safety non-toxic, non-stimulated, having no side effect, do not develop immunity to drugs, is Novel mouth sterilization, sterilizing clean-keeping articles for use.
Above a kind of novel polysaccharide antimicrobial mouthwash provided by the present invention and preparation method thereof is described in detail.Set forth principle of the present invention and embodiment herein by detailed description of the invention, above explanation just understands method of the present invention and core concept thereof for helping.It should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention, can also carry out some improvement and modification to the present invention, these improve and modify and also fall in the protection domain of the claims in the present invention.
Claims (3)
1. novel polysaccharide antimicrobial mouthwash and preparation method thereof, is characterized in that, its constituent mass percentage composition is:
Carboxymethyl chitosan: 1 ~ 3%
Propolis: 1 ~ 5%
Chinese herbal medicine concentrated solution: 0.5 ~ 1%
Sodium alginate: 0.2 ~ 0.5%
Oleum menthae: 0.01 ~ 0.05%
Acid-base modifier: 0.1 ~ 0.5%
Ethanol: 5 ~ 15%
Surplus is purified water,
Wherein said the concentrated liquid of tradition Chinese medicine is with 10 ~ 15 weight portion Flos Loniceraes, 13 ~ 17 weight portion Flos Chrysanthemi Indicis, 12 ~ 18 weight portion Rhizoma Corydalis, 12 ~ 18 weight portion green tea, 3 ~ 7 weight portion Herba Asaris for crude drug, and every ml that water boiling concentration is made contains the concentrated liquid of tradition Chinese medicine of crude drug 0.5 ~ 1.5mg.
2. novel polysaccharide antimicrobial mouthwash as above and preparation method thereof, is characterized in that comprising the steps:
(1) directly joined in dissolution kettle by carboxymethyl chitosan, dissolve by purified water, open calorstat, mechanical agitation at temperature is T=40 ~ 50 DEG C, until carboxymethyl chitosan all dissolves;
(2) directly join in dissolution kettle after propolis being dissolved with ethanol, ensure that solution is uniform state;
(3) be 5.0 ~ 6.5 with the pH value of acid-base modifier regulating step (2) gained solution;
(4) in step (3) gained solution, add Chinese herbal medicine concentrated solution, sodium alginate, Oleum menthae, regulate temperature to be 30 ~ 40 DEG C, continue to be uniformly mixed;
(5) step (4) gained solution is delivered to next step operation subpackage, after detection meets product standard, pack, make finished product.
3. a kind of novel polysaccharide antimicrobial mouthwash according to claim 1 and preparation method thereof, is characterized in that described acid-base modifier is one or both in sodium hexameta phosphate, tetrasodium pyrophosphate.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105919902A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Gargle for relieving thirst, wetting throat and resisting bacteria and preparation method thereof |
| CN105963237A (en) * | 2016-07-06 | 2016-09-28 | 广东科玮生物技术股份有限公司 | Novel gargle and preparation method as well as application thereof |
| CN105997792A (en) * | 2016-06-21 | 2016-10-12 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine mothproofing and tooth-protecting gargle and preparation method thereof |
| CN106176546A (en) * | 2016-08-26 | 2016-12-07 | 湖北立天生物工程有限公司 | Based on the cleaning of the chitosan derivatives degree of depth, bacteriostatic tooth protective collutory and preparation method thereof |
| CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
| CN110575414A (en) * | 2018-06-08 | 2019-12-17 | 广州医家仁生物科技有限责任公司 | Chinese herbal medicine plant oral cavity maintenance composition and preparation method and use method thereof |
| CN113476386A (en) * | 2021-08-19 | 2021-10-08 | 杭州迅腾医疗器械有限公司 | Gargle and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105997792A (en) * | 2016-06-21 | 2016-10-12 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicine mothproofing and tooth-protecting gargle and preparation method thereof |
| CN105919902A (en) * | 2016-06-29 | 2016-09-07 | 江苏开源康达医疗器械有限公司 | Gargle for relieving thirst, wetting throat and resisting bacteria and preparation method thereof |
| CN105963237A (en) * | 2016-07-06 | 2016-09-28 | 广东科玮生物技术股份有限公司 | Novel gargle and preparation method as well as application thereof |
| CN106344428A (en) * | 2016-07-27 | 2017-01-25 | 青岛琛蓝海洋生物工程有限公司 | Marine polysaccharide-based dry mouth symptom relieving mouthwash and preparation method thereof |
| CN106176546A (en) * | 2016-08-26 | 2016-12-07 | 湖北立天生物工程有限公司 | Based on the cleaning of the chitosan derivatives degree of depth, bacteriostatic tooth protective collutory and preparation method thereof |
| CN110575414A (en) * | 2018-06-08 | 2019-12-17 | 广州医家仁生物科技有限责任公司 | Chinese herbal medicine plant oral cavity maintenance composition and preparation method and use method thereof |
| CN113476386A (en) * | 2021-08-19 | 2021-10-08 | 杭州迅腾医疗器械有限公司 | Gargle and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN105310960B (en) | 2018-03-30 |
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