CN101172129B - Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof Download PDFInfo
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- CN101172129B CN101172129B CN2007101772555A CN200710177255A CN101172129B CN 101172129 B CN101172129 B CN 101172129B CN 2007101772555 A CN2007101772555 A CN 2007101772555A CN 200710177255 A CN200710177255 A CN 200710177255A CN 101172129 B CN101172129 B CN 101172129B
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- 206010014080 Ecchymosis Diseases 0.000 title claims abstract description 38
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000007920 subcutaneous administration Methods 0.000 title abstract 3
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- 229940079593 drug Drugs 0.000 claims abstract description 11
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 11
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 1
- 239000010446 mirabilite Substances 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
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- 239000002994 raw material Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
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Abstract
The invention discloses a traditional Chinese medicine composition for treating subcutaneous ecchymosis and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1-5 parts of moutan bark, 1-5 parts of red peony root and 1-5 parts of mirabilite. The traditional Chinese medicine composition is directly or indirectly added with pharmaceutically acceptable excipients and then prepared into various clinically acceptable external preparations according to the conventional preparation process. The traditional Chinese medicine composition has the functions of promoting blood circulation, removing blood stasis and reducing swelling, and clinical tests show that the traditional Chinese medicine composition has definite curative effect on subcutaneous ecchymosis, is safe and has no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of ecchymosis and preparation method thereof belongs to the field of Chinese medicines.
Background technology
Ecchymosis is because a variety of causes blood capillary, vein and the arteries breakage that cause, and perhaps blood coagulation system disorders as thrombocytopenia etc., causes blood to stay in the state of extravascular tissue.Common is various wounds, and the operation of vascular punctures such as venous transfusion, blood drawing, radiography all can cause the skin ecchymosis.The generation of skin ecchymosis, not only can make the patient produce the emotion of anxiety and tense, also can give next intravenous administration, blood sampling or puncture bring difficulty, increase the chance of secondary infection, the influence treatment especially is the traumatic bigger operation of blood vessel, the incidence rate height of skin ecchymosis, and the bigger difficult absorption healing of ecchymosis area.
The skin ecchymosis that at present a variety of causes is caused still lacks effective Therapeutic Method.Generally be the method for taking to give free rein to and absorbing, have only larger area just to take intervening measure, as: hot compress, magnesium sulfate dressing, millimeter-wave irradiation, bright Aloe external application etc.Clinical data shows, the absorption of skin ecchymosis, and the lighter is general, and a week disappears, weight person needs 2-3 week, has a strong impact on patient's emotion, has prolonged the hospital stays, increased patient's psychological burden and hospitalization cost, therefore, the method for treatment skin ecchymosis just seems particularly important.
Summary of the invention
The inventor is according to for many years clinical experience, gropes and debugs through repeatedly clinical, chooses one group of ecchymosis that a variety of causes is caused and all has the Chinese medicine composition of good therapeutic effect, thereby finished the present invention.
One of the object of the invention is to provide a kind of Chinese medicine composition for the treatment of ecchymosis.
Another purpose of the present invention is to provide a kind of method for preparing above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved by the following technical solution:
A kind of Chinese medicine composition for the treatment of ecchymosis is made by each crude drug of following weight portion: Cortex Moutan 1-5 weight portion, Radix Paeoniae Rubra 1-5 weight portion and Natrii Sulfas 1-5 weight portion.
The weight portion of preferred each crude drug is: Cortex Moutan 3 weight portions, Radix Paeoniae Rubra 2 weight portions, Natrii Sulfas 1 weight portion.
The inventor is according to internal organs theory of channels and collaterals and QI and blood theory, learn achievement in research in conjunction with modern Chinese medicine, by clinical research for many years, the cause of disease, pathogenesis and the syndrome characteristics of ecchymosis have been discussed from combination of Chinese and Western medicine angle, summing up with promoting blood circulation to remove blood stasis, detumescence is the outer treating method of the rule of treatment, thereby determines this side.
Cortex Moutan: be the dry root bark of cohosh Paeonia suffruticosa Paeonia suffrutico Andr..Excavate root autumn, remove radicula, strip root bark, dry.Nature and flavor with return through: bitter, hot, be slightly cold.GUIXIN, liver, kidney channel.Function with cure mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Radix Paeoniae Rubra: be the dry root of cohosh Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor with return through: hardship is slightly cold.Return Liver Channel.Function with cure mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.
Natrii Sulfas: be Sulfates mineral Natrii Sulfas, the crystalline solid that forms through processing and refining.The main aqueous sulfuric acid sodium (Na that contains
2SO
410H
2O).Nature and flavor with return through: salty, bitter, cold.Return stomach, large intestine channel.Function with cure mainly: purging heat to relax the bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat.
The used crude drug of the present invention all can be bought from common pharmacy and obtain, and its specification meets national medical standard.
Required various adjuvants when medicine activity component of the present invention can add the different exterior-applied formulation of preparation, method of Chinese medicinal with routine is prepared into any suitable external preparations, and this external preparation includes but not limited to: Wet-dressing agent, ointment, stick agent, Emulsion, glued membrane agent, gel, paste, plaster, lotion, penetrating agent or tincture.
Preferably, a kind of method for preparing Chinese medicine composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion;
(2) Cortex Moutan, Radix Paeoniae Rubra water are decocted 1-8 time, be blended into Natrii Sulfas after decocting liquid is concentrated, often regulation agent moulding process is prepared into various exterior-applied formulations.
Preferably, in the step (2) Cortex Moutan, Radix Paeoniae Rubra are boiled 4 times with the decocting of 3 times of weight, decocted 1 hour at every turn.
Chinese medicine composition of the present invention has promoting blood circulation to remove blood stasis, repercussive effect, can effectively treat because the ecchymosis that a variety of causes caused is that blood stays in hypodermic state, for example: the damaged blood that causes of blood capillary, vein or arteries that causes owing to various wounds, vascular puncture etc. stays in subcutaneous tissue; Perhaps the blood that causes owing to the blood coagulation system disorders stays in subcutaneous tissue.
The usage of Chinese medicine composition of the present invention and consumption: the dosage of medicine of the present invention depends on concrete dosage form, and factor such as age of patient, body weight, health status.As guidance: Wet-dressing agent: be covered in the ecchymosis affected part, scope surpasses the 1-2cm of ecchymosis area, with the preservative film parcel, fixes with adhesive tape outward, and 2 times/day, 3 days is a course of treatment.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention the details of technical solution of the present invention and form.
The preparation of embodiment 1 Wet-dressing agent
Take by weighing each crude drug (unit: g): Cortex Moutan 30, Radix Paeoniae Rubra 20, Natrii Sulfas 10 by following weight; Cortex Moutan, Radix Paeoniae Rubra are boiled 2 times with the decocting of 3 times of weight respectively, decocted 1 hour at every turn, merge decoction liquor, filter, be blended into Natrii Sulfas after filtrate is concentrated, get admixing medical solutions, soak sterile gauze with admixing medical solutions, sterilization, promptly.
The preparation of embodiment 2 ointments
Take by weighing each crude drug (unit: g): Cortex Moutan 10, Radix Paeoniae Rubra 10, Natrii Sulfas 10 by following weight; Cortex Moutan, Radix Paeoniae Rubra being boiled 8 times with the decocting of 2 times of weight respectively, decocted 0.5 hour at every turn, merge decoction liquor, filter, filtrate is concentrated, be blended into Natrii Sulfas, is substrate with vaseline, is prepared into ointment according to the conventional formulation moulding process.
Embodiment 3 sticks the preparation of agent
Take by weighing each crude drug (unit: g): Cortex Moutan 10, Radix Paeoniae Rubra 10, Natrii Sulfas 10 by following weight; Cortex Moutan, Radix Paeoniae Rubra being boiled 8 times with the decocting of 2 times of weight, decocted 0.5 hour at every turn, merge decoction liquor, filter, filtrate is concentrated, be blended into Natrii Sulfas, is substrate with vaseline, is prepared into ointment according to the conventional formulation molding; Prepare framework controlled release type transdermal delivery system with polyurethane sponge, pressure sensitive adhesive tape, isolating membrane, the separate paper that scribbles dimethicone; The polyurethane sponge that 2-6cm is square as controlled release matrix immerse be adsorbed in the above-mentioned ointment saturated, take out, be positioned on the isolating membrane of the square pressure sensitive adhesive tape middle part of 3-7cm, cover the separate paper that scribbles dimethicone then, sealing promptly in the packaging bag of packing into.
The 1 traditional Chinese medicine composition for treating ecchymosis clinical summary report of the present invention of test example
One, object of study
Case is selected from March, 2007, at Xuan Wu hospital neruosurgery and general medicine inpatient totally 60 examples, 16～90 years old age.
Selected patient's case all meets the ecchymosis evaluation criterion: severe: ecchymosis darkviolet, area 〉=4 * 4cm2; Moderate: ecchymosis purple, area 〉=2 * 2cm
2Slightly: the purple light color of ecchymosis, area＜2 * 2cm2.The selected patient of 60 examples is divided into experimental group (adopting Chinese medicine composition of the present invention to treat) 30 example and matched group (using 50% Adlerika) 30 examples.Two groups of patient's sexes.Age, ecchymosis position and operating technology reason geometric ratio school, no difference of science of statistics (P＜0.05) has comparability (table 1,2).
Table 1. a liang group patient treat last as situation
The ecchymosis situation relatively before table 2. a liang group patient treated
Two, Therapeutic Method
Experimental group: the embodiment of the invention 1 prepared Wet-dressing agent is covered in the ecchymosis affected part, and scope surpasses the 1-2cm of ecchymosis area, with the preservative film parcel, fixes with adhesive tape outward, and 2 times/day, 3 days is a course of treatment.
Matched group: give 50% magnesium sulfate and in kind treat.
Three, efficacy assessment standard
Two groups equal 3 days be a course of treatment, begin after 3 days the statistics.
Produce effects; Ecchymosis complete obiteration or area dwindle 〉=and 80%, color is obviously thin out.
Effectively: the ecchymosis area dwindles 〉=and 40%, color is thin out.
Invalid: the ecchymosis area dwindles＜and 40%, color does not have significant change.
Four, statistical method
With gained data software processes, enumeration data is used X
2Check.
Five, clinical observation result
Two groups of curative effects relatively (seeing Table 3) illustrates that the experimental group effective percentage is significantly higher than matched group (P＜0.01), illustrate that Chinese medicine composition of the present invention can effectively treat ecchymosis, and its curative effect will obviously be better than treating at present the medicine magnesium sulfate that ecchymosis is used always.
Curative effect relatively behind the table 3. liang group patient treatment
Claims (9)
1. a Chinese medicine composition for the treatment of ecchymosis is made by each crude drug of following weight portion: Cortex Moutan 1-5 weight portion, Radix Paeoniae Rubra 1-5 weight portion and Natrii Sulfas 1-5 weight portion.
2. according to the Chinese medicine composition of claim 1, it is characterized in that the weight portion of each crude drug is: Cortex Moutan 3 weight portions, Radix Paeoniae Rubra 2 weight portions, Natrii Sulfas 1 weight portion.
3. according to the Chinese medicine composition of claim 1 or 2, it is characterized in that: the method for Chinese medicinal according to routine is prepared into any suitable external preparations.
4. according to the Chinese medicine composition of claim 3, it is characterized in that described external preparation is: Wet-dressing agent, ointment, stick agent, Emulsion, paste, plaster, lotion or tincture.
5. method for preparing the Chinese medicine composition of claim 1 or 2 comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) Cortex Moutan, Radix Paeoniae Rubra water are decocted 1-8 time, be blended into Natrii Sulfas after decocting liquid is concentrated, become external preparation through the preparations shaping prepared.
6. according to the method for claim 5, it is characterized in that: in the step (2) Cortex Moutan, Radix Paeoniae Rubra are boiled 4 times with the decocting of 3 times of weight, decocted 1 hour at every turn.
7. the purposes of any Chinese medicine composition of claim 1-4 in the medicine of preparation treatment ecchymosis.
8. according to the purposes of claim 7, it is characterized in that: described ecchymosis is meant that blood stays in hypodermic state.
9. according to the purposes of claim 8, it is characterized in that: described ecchymosis is meant owing to the damaged blood that causes of the blood capillary that various wounds, vascular puncture cause, vein or arteries stays in subcutaneous tissue; Perhaps the blood that causes owing to the blood coagulation system disorders stays in subcutaneous tissue.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101772555A CN101172129B (en) | 2007-11-13 | 2007-11-13 | Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101772555A CN101172129B (en) | 2007-11-13 | 2007-11-13 | Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof |
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| CN101172129B true CN101172129B (en) | 2011-07-20 |
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| CN103908501B (en) * | 2014-03-14 | 2016-01-20 | 王建梅 | A kind of Chinese medicine composition for the treatment of pityriasis rosea |
| CN104225526A (en) * | 2014-08-28 | 2014-12-24 | 王萍 | Traditional Chinese medicinal composition for treating skin bruising after transfusion |
| CN104666447A (en) * | 2015-03-13 | 2015-06-03 | 山东大学第二医院 | Traditional Chinese medicine composition for treating extravasated blood and ecchymosis after puncture |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097604C (en) * | 1996-10-09 | 2003-01-01 | 巴斯福股份公司 | Process for preparing polytetrahydrofuran and derivs thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1097604C (en) * | 1996-10-09 | 2003-01-01 | 巴斯福股份公司 | Process for preparing polytetrahydrofuran and derivs thereof |
Non-Patent Citations (2)
| Title |
|---|
| 谢圣金.清热化瘀煎治验举隅.铁道医学13 4.1985,13(4),254. |
| 谢圣金.清热化瘀煎治验举隅.铁道医学13 4.1985,13(4),254. * |
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