CN103908501B - A kind of Chinese medicine composition for the treatment of pityriasis rosea - Google Patents
A kind of Chinese medicine composition for the treatment of pityriasis rosea Download PDFInfo
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- CN103908501B CN103908501B CN201410112316.XA CN201410112316A CN103908501B CN 103908501 B CN103908501 B CN 103908501B CN 201410112316 A CN201410112316 A CN 201410112316A CN 103908501 B CN103908501 B CN 103908501B
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- 238000011282 treatment Methods 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 206010035114 pityriasis rosea Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 241000202296 Delphinium Species 0.000 claims abstract description 10
- 241000628997 Flos Species 0.000 claims abstract description 10
- 241001116755 Selliguea Species 0.000 claims abstract description 10
- 208000037920 primary disease Diseases 0.000 abstract description 5
- 210000003205 muscle Anatomy 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 206010040882 skin lesion Diseases 0.000 description 7
- 231100000444 skin lesion Toxicity 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229940124623 antihistamine drug Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000001058 brown pigment Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000020995 raw meat Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of pityriasis rosea.Primary disease is many by the pungent savoury of surfeit, or the strongly fragrant fire-transformation of a specified duration of feelings will, and hyperamization divides intrinsic heat, and feel wind heat exopathogen again, closing skin space between skin and muscles forms.The present invention selects Bai Radix Achyranthis Bidentatae, Radix Sophorae Viciifoliae, Phymatopsis hastata (Thunb.) Kitag., Flos Hibisci Mutabilis, Delphinium brunonianum Royle, Herba Zebrinae Pendulae, Herba Sebi drymarioidis, Herba Murdanniae Simplicis, decocting becomes decoction, and through clinical trial, total effective rate is 92.11%, obviously be better than 73.68% of matched group, evident in efficacy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of pityriasis rosea.
Background technology
Pityriasis rosea is a kind of clinical common inflammatory dermatoses, the cause of disease is still not clear, think relevant with viral infection more, though this disease has self limiting, small number of patients still can be extended down to could fully recover half a year more than, and is more common in the young and the middle aged due to primary disease, this age bracket patient requires higher to quality of life, therefore active treatment has very important meaning to patient, the traditional therapies such as antihistamine drug, generally based on symptomatic treatment, effectively can not shorten the course of disease.I finds through clinical observation for many years, utilizes treatment by Chinese herbs pityriasis rosea to have good curative effect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of pityriasis rosea.Pityriasis rosea " the secret record of surgery " is called " pityriasis rosea ", primary disease is many by the pungent savoury of surfeit, or the strongly fragrant fire-transformation of a specified duration of feelings will, hyperamization divides intrinsic heat, and feel wind heat exopathogen again, closing skin space between skin and muscles forms, as Golden Mirror of Medicine: " this card is formed by the inaccessible space between skin and muscles of wind heat; shape, as purple scabies, is done during sufferings, the dry frequent fever of blood.”
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment pityriasis rosea is made up of the Chinese medicine of following weight portion: Radix Cucubali 20-30 part, Radix Sophorae Viciifoliae 9-15 part, Phymatopsis hastata (Thunb.) Kitag. 15-20 part, Flos Hibisci Mutabilis 6-12 part, Delphinium brunonianum Royle 2-6 part, Herba Zebrinae Pendulae 30-40 part, Herba Sebi drymarioidis 15-30 part, Herba Murdanniae Simplicis 30-50 part.
Preferably, Radix Cucubali 25 parts, Radix Sophorae Viciifoliae 12 parts, Phymatopsis hastata (Thunb.) Kitag. 18 parts, Flos Hibisci Mutabilis 9 parts, Delphinium brunonianum Royle 4 parts, Herba Zebrinae Pendulae 35 parts, Herba Sebi drymarioidis 22.5 parts, Herba Murdanniae Simplicis 40 parts.
Preparation method: make decoction by traditional preparation method decocting.
Fang Zhong: Radix Cucubali clearing away heat and cooling blood, expelling wind and removing dampness, inducing diuresis to remove edema; Radix Sophorae Viciifoliae, Phymatopsis hastata (Thunb.) Kitag., Herba Zebrinae Pendulae clearing away heat and cooling blood, removing toxic substances; Flos Hibisci Mutabilis, Herba Sebi drymarioidis clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling; Delphinium brunonianum Royle removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching; Herba Murdanniae Simplicis clearing away heat and cooling blood, diuresis removing toxic substances.
Clinical data
1. physical data 76 example observation case all carrys out self-Out-patient Department, man 43 example, female 33 example, 20 ~ 42 years old age, average 29.7 years old, course of disease 3-7 days, average 5.25 days, patient was divided into two groups by stochastic sampling, treatment group 38 example, matched group 38 example, two groups of patients are statistical test there are no significant difference (P > 0.05) in sex, age, the course of disease, state of an illness weight etc., has comparability.
2. diagnostic criteria is with reference to the diagnostic criteria of " skin cypridology " pityriasis rosea: 1. initial stage skin lesion is isolated rose-colored light red mottle, on be covered with thin thin squama, after 1-2 week, neck, trunk and extremity near-end engender the rose-colored light red speckle of the ellipse differed in size, the same mother's mark of shape, and edge is covered with the inside thin thin squama of free edge, skin lesion major axis is parallel with dermatoglyph, 2. skin lesion is often with pruritus in various degree, and 3. primary disease has self limiting, and the course of disease is generally 4-8 week.Tcm diagnosis is with reference to the diagnostic criteria of pityriasis rosea in " the Chinese medical disease clinical efficacy standard " of State Administration of Traditional Chinese Medicine's formulation in 1994.
3. the oral Chinese medicine composition of the present invention of Therapeutic Method treatment group patient: take Radix Cucubali 25g, Radix Sophorae Viciifoliae 12g, Phymatopsis hastata (Thunb.) Kitag. 18g, Flos Hibisci Mutabilis 9g, Delphinium brunonianum Royle 4g, Herba Zebrinae Pendulae 35g, Herba Sebi drymarioidis 22.5g, Herba Murdanniae Simplicis 40g, decoction is become by traditional method decocting, every agent 100ml, every day 1 dose.Matched group: loratadine tablet 10mgqd, vitamin C 0.1tid, the two groups of momestasone furoate of external all simultaneously cream, all patients treatments period 7d follows up a case by regular visits to once, carries out curative effect statistics after 21d.Treatments period does not use other methods relevant with treatment primary disease to treat, and all terminates rear judgement curative effect the course for the treatment of, and advises raw meats such as avoiding edible fish and shrimp Carnis caprae seu ovis Fructus Capsici to send out maror.
4. curative effect determinate standard drafts criterion of therapeutical effect with reference to " Chinese medical disease clinical efficacy standard ": recovery from illness: skin lesion disappears, and pruritus disappears, and clinically leaves the calm speckle of brown pigment; Effective: for skin lesion disappear >=70%, pruritus obviously alleviates; Effective: skin lesion disappears 40%-69%, and pruritus alleviates; Invalid: skin lesion disappears < 40%.
5. therapeutic outcome two groups of patients are after the treatment of 21 days, and treatment group total effective rate 92.11%, higher than matched group 73.68%, has statistical significance.Concrete outcome sees the following form:
The comparison of table 1 liang group patient curative effect
Adopt X
2inspection, P < 0.05.
6. untoward reaction treatments period does not find toxicity.
Detailed description of the invention
Embodiment one: take Radix Cucubali 25g, Radix Sophorae Viciifoliae 12g, Phymatopsis hastata (Thunb.) Kitag. 18g, Flos Hibisci Mutabilis 9g, Delphinium brunonianum Royle 4g, Herba Zebrinae Pendulae 35g, Herba Sebi drymarioidis 22.5g, Herba Murdanniae Simplicis 40g, makes decoction by traditional preparation method decocting.
Embodiment two: take Radix Cucubali 30g, Radix Sophorae Viciifoliae 9g, Phymatopsis hastata (Thunb.) Kitag. 15g, Flos Hibisci Mutabilis 6g, Delphinium brunonianum Royle 2g, Herba Zebrinae Pendulae 40g, Herba Sebi drymarioidis 15g, Herba Murdanniae Simplicis 30g, makes decoction by traditional preparation method decocting.
Embodiment three: Radix Cucubali 20g, Radix Sophorae Viciifoliae 15g, Phymatopsis hastata (Thunb.) Kitag. 20g, Flos Hibisci Mutabilis 12g, Delphinium brunonianum Royle 6g, Herba Zebrinae Pendulae 30g, Herba Sebi drymarioidis 30g, Herba Murdanniae Simplicis 50g, makes decoction by traditional preparation method decocting.
Claims (2)
1. treat a Chinese medicine composition for pityriasis rosea, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Cucubali 20-30 part, Radix Sophorae Viciifoliae 9-15 part, Phymatopsis hastata (Thunb.) Kitag. 15-20 part, Flos Hibisci Mutabilis 6-12 part, Delphinium brunonianum Royle 2-6 part, Herba Zebrinae Pendulae 30-40 part, Herba Sebi drymarioidis 15-30 part, Herba Murdanniae Simplicis 30-50 part.
2. a kind of Chinese medicine composition for the treatment of pityriasis rosea as claimed in claim 1, is characterized in that Radix Cucubali 25 parts, Radix Sophorae Viciifoliae 12 parts, Phymatopsis hastata (Thunb.) Kitag. 18 parts, Flos Hibisci Mutabilis 9 parts, Delphinium brunonianum Royle 4 parts, Herba Zebrinae Pendulae 35 parts, Herba Sebi drymarioidis 22.5 parts, Herba Murdanniae Simplicis 40 parts.
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| CN201410112316.XA CN103908501B (en) | 2014-03-14 | 2014-03-14 | A kind of Chinese medicine composition for the treatment of pityriasis rosea |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101172129A (en) * | 2007-11-13 | 2008-05-07 | 首都医科大学宣武医院 | Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof |
| CN102370917A (en) * | 2011-10-26 | 2012-03-14 | 文登市口腔医院 | Traditional Chinese medicine for treating pityriasis rosea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20110058753A (en) * | 2011-04-15 | 2011-06-01 | (주)아모레퍼시픽 | Composition for soothing scalp and improving hair conditioning containing herbal extract |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101172129A (en) * | 2007-11-13 | 2008-05-07 | 首都医科大学宣武医院 | Traditional Chinese medicine composition for treating subcutaneous ecchymosis and preparation method thereof |
| CN102370917A (en) * | 2011-10-26 | 2012-03-14 | 文登市口腔医院 | Traditional Chinese medicine for treating pityriasis rosea |
Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗老年性皮肤瘙痒病78例;梁存让;《中级医刊》;19861231(第5期);第50-51页 * |
| 香蓉散外敷治疗颜面疔疮26例;周聪和;《湖南中医杂志》;19891231(第4期);第41页 * |
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Inventor after: Wang Jianmei Inventor after: Yao Meiyan Inventor before: Wang Jianmei Inventor before: Chen Shufeng |
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Effective date of registration: 20170809 Address after: 276400 Yishui people's Hospital, Zhengyang Road, Yishui, Shandong, China, No. 33, Linyi Co-patentee after: Yao Meiyan Patentee after: Wang Jianmei Address before: 276400 Yishui people's Hospital, Zhengyang Road, Yishui, Shandong, China, No. 33, Linyi Patentee before: Wang Jianmei |
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