CN107050351B - Traditional Chinese medicine composition for relaxing bowel and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for relaxing bowel and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for relaxing bowel, which is prepared from the following raw materials in parts by weight: 10-30 parts of cistanche, 20-40 parts of black sesame, 5-18 parts of fructus cannabis, 5-15 parts of bunge cherry seed, 5-15 parts of dried orange peel and 8-20 parts of malt. The invention also discloses application of the traditional Chinese medicine composition in preparation of a medicine or health-care product with the effect of relaxing bowel. The invention also discloses an ointment containing the traditional Chinese medicine composition for relaxing bowel. The traditional Chinese medicine composition has a reasonable formula, each component is absent, cistanche in the formula is a medicine for kidney channel and blood, the traditional Chinese medicine composition has the effects of warming and invigorating kidney yang, nourishing blood and moistening dryness, tonifying yang qi but not dryness, and nourishing yin blood but not greasy, is a monarch medicine, bunge cherry seeds are good at smoothing intestine and relaxing bowels, and can induce diuresis, fructus cannabis is nourishing and moistening dryness, and the effect is mild, the two medicines are ministerial medicines, black sesame is nourishing yin blood, nourishing liver and kidney, dried orange peel is regulating qi and tonifying spleen, malt is helping digestion, and the two medicines are used as assistant and guide. The six medicines are used in combination to mutually promote and strengthen the force of smoothing intestines and relaxing bowels.
Description
Technical Field
The invention belongs to the technical field of health-care food, relates to a traditional Chinese medicine composition and a preparation method and application thereof, and particularly relates to a composition for relaxing bowel and a preparation method and application thereof.
Background
With the continuous acceleration of life rhythm and the change of eating habits, constipation becomes a common disease of middle-aged and elderly people and office workers, and is in a trend of youthful appearance. Constipation mainly refers to the reduction of defecation frequency, the reduction of feces quantity, the dry and hard feces, the labor waste in defecation and the like. The constipation is caused by dysfunction of large intestine, heat accumulation in stomach and intestine, body fluid consumption, constipation, and long retention time in intestinal tract. Constipation has great harm to human body, and constipation causes difficulty in defecation, dry feces, hemorrhoids are easily formed by pressing anus veins, and the constipation is difficult. Meanwhile, the patients with constipation have anxiety, anxiety and distraction, which affect daily life and work. Some patients take cathartic or use traditional Chinese medicine enema to solve the difficult defecation, but the fundamental problem can not be solved. Therefore, the development of the health food for relaxing bowel is of great significance.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for relaxing bowel, a preparation method and application thereof.
The purpose of the invention can be realized by the following technical scheme:
a traditional Chinese medicine composition for relaxing bowel is prepared from the following raw materials in parts by weight: 10-30 parts of cistanche, 20-40 parts of black sesame, 5-18 parts of fructus cannabis, 5-15 parts of bunge cherry seed, 5-15 parts of dried orange peel and 8-20 parts of malt.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of cistanche, 25-40 parts of black sesame, 5-15 parts of fructus cannabis, 5-15 parts of bunge cherry seed, 5-15 parts of dried orange peel and 10-20 parts of malt.
Further preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of cistanche, 25-35 parts of black sesame, 5-15 parts of fructus cannabis, 5-10 parts of bunge cherry seed, 5-10 parts of dried orange peel and 10-15 parts of malt
Specifically, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of cistanche, 25 parts of black sesame, 5 parts of fructus cannabis, 5 parts of bunge cherry seed, 5 parts of dried orange peel and 10 parts of malt; or 30 parts of cistanche, 40 parts of black sesame, 15 parts of fructus cannabis, 15 parts of bunge cherry seed, 15 parts of dried orange peel and 20 parts of malt; or 20 parts of cistanche, 30 parts of black sesame, 10 parts of fructus cannabis, 8 parts of bunge cherry seed, 6 parts of dried orange peel and 15 parts of malt.
The preparation method of the traditional Chinese medicine composition is characterized by comprising the following steps:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, and sieving; pulverizing fructus Cannabis, and sieving;
(2) extraction: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water which is 8-12 times of the total amount of the medicinal materials, extracting for 1-3 times for 1-3 hours each time, cooling the extracting solution, and filtering with a 200-400-mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously, lifting stirring rod to obtain medicinal liquid, hanging flag, and stopping heating to obtain paste composition.
In the step (1), the black sesame, the bunge cherry seeds and the fructus cannabis are ground into powder and then are sieved by a sieve of 60-80 meshes.
The traditional Chinese medicine composition has the effect of relaxing bowel, so that the invention also aims to provide the application of the traditional Chinese medicine composition in preparing medicines or health-care products with the effect of relaxing bowel.
The invention relates to a medicament or health product for relaxing bowel, which contains the traditional Chinese medicine composition. Preferably, the dosage form of the medicament is paste.
The bowel relaxing ointment is prepared by the following method: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water 8-12 times of the total amount of the medicinal materials, extracting for 1-3 times for 1-3 hours each time, cooling, filtering, and mixing filtrates; heating the filtrate to boil, concentrating with slow fire until the filtrate is concentrated to three fifths of the original filtrate volume, and stopping heating; adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste; sterilizing, filling, and sterilizing for the second time to obtain the final product of the paste for relaxing bowel.
The invention also aims to provide a preparation method of the bowel relaxing paste, which comprises the following steps:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, and sieving; pulverizing fructus Cannabis, and sieving;
(2) extraction: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water in an amount which is 8-12 times of the total amount of the medicinal materials, decocting and extracting for 1-3 times with water for 1-3 hours each time, cooling the extracting solution, and filtering with a 200-400-mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste;
(5) and (3) sterilization: sterilizing the paste obtained in the step (4) at a high temperature of 120-150 ℃ for 10-40 s;
(6) filling: cooling to 36-40 ℃, and filling and sealing by a vacuum filling machine;
(7) secondary sterilization: and (3) sterilizing for 15-30 minutes at 80-90 ℃ by using a sterilization kettle to obtain the finished product of the bowel relaxing paste.
The temperature of the slow fire is 120-150 ℃.
The invention has the beneficial effects that:
the traditional Chinese medicine composition provided by the invention has a reasonable formula, wherein each component is absent, cistanche can tonify kidney and replenish essence, and can relax bowel, black sesame can tonify liver and kidney, can replenish essence and blood, and can relax bowel, fructus cannabis and bunge cherry seed can relax bowel, pericarpium citri reticulatae can regulate qi and regulate the middle warmer, and malt can promote qi circulation and promote digestion. The kidney-qi deficiency and the body fluids are withered and scanty, resulting in dysfunction of the spleen in transportation, dry and astringent large intestine and failure of transmission, resulting in constipation. The cistanche in the formula is a medicine for tonifying kidney meridian and blood, has the effects of warming and invigorating kidney yang, nourishing blood and moistening dryness, tonifying yang qi but not dryness, nourishing yin blood but not greasiness, is a monarch medicine, the bunge cherry seed is good at relaxing bowels, and can induce diuresis, the fructus cannabis is nourishing and moistening dryness, the effects are mild, the two are ministerial medicines, the black sesame is nourishing yin blood, nourishing liver and kidney, the dried orange peel is regulating qi and tonifying spleen, and the malt is helping digestion, and are used as an assistant and a guide together. The six medicines are used in combination to mutually promote and strengthen the force of smoothing intestines and relaxing bowels.
The traditional Chinese medicine composition prepared into paste has the effects of relaxing bowel, tonifying kidney, moistening dryness, regulating qi and strengthening spleen, and also has the advantages of simple preparation process, good curative effect, easiness in popularization and the like.
Detailed Description
The present invention is further illustrated by the following examples, but the scope of the invention is not limited thereto.
Example 1
The following raw materials in parts by weight are selected: 10 parts of cistanche, 25 parts of black sesame, 5 parts of fructus cannabis, 5 parts of bunge cherry seed, 5 parts of dried orange peel and 10 parts of malt; the bowel relaxing ointment is prepared according to the following preparation method:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, pulverizing fructus Cannabis, and sieving with 60 mesh sieve;
(2) extraction: cleaning Cistanchis herba, pericarpium Citri Tangerinae and fructus Hordei Germinatus with water, mixing, adding purified water 8 times of the total amount of the medicinal materials, decocting with water for 1 time, each time for 1 hr, cooling the extractive solution, and filtering with 200 mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste;
(5) and (3) sterilization: placing the paste obtained in the step (4) in a container, and sterilizing at 150 ℃ for 10 s;
(6) filling: cooling to 36 ℃, and filling and sealing by a vacuum filling machine;
(7) secondary sterilization: sterilizing for 15 minutes at 90 ℃ by using a sterilization kettle to prepare the finished product of the bowel relaxing ointment.
Example 2
The preparation method comprises the following steps of: 30 parts of cistanche, 40 parts of black sesame, 15 parts of fructus cannabis, 15 parts of bunge cherry seed, 15 parts of dried orange peel and 20 parts of malt; the bowel relaxing ointment is prepared according to the following preparation method:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, pulverizing fructus Cannabis, and sieving with 80 mesh sieve;
(2) extraction: cleaning Cistanchis herba, pericarpium Citri Tangerinae and fructus Hordei Germinatus with water, mixing, adding purified water 10 times of the total amount of the medicinal materials, decocting with water for 2 times, each time for 2 hr, cooling the extractive solution, and filtering with 400 mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste;
(5) and (3) sterilization: placing the paste obtained in the step (4) in a container, and sterilizing at high temperature of 120 ℃ for 30 s;
(6) filling: cooling to 40 deg.C, vacuum filling, and sealing;
(7) secondary sterilization: sterilizing for 30 minutes at 80 ℃ by using a sterilization kettle to prepare the finished product of the bowel relaxing ointment.
Example 3
The preparation method comprises the following steps of: 20 parts of cistanche, 30 parts of black sesame, 10 parts of fructus cannabis, 8 parts of bunge cherry seed, 6 parts of dried orange peel and 15 parts of malt; the bowel relaxing ointment is prepared according to the following preparation method:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, pulverizing fructus Cannabis, and sieving with 65 mesh sieve;
(2) extraction: cleaning Cistanchis herba, pericarpium Citri Tangerinae and fructus Hordei Germinatus with water, mixing, adding purified water 12 times of the total amount of the medicinal materials, decocting with water for 3 times, each time for 3 hr, cooling the extractive solution, and filtering with 300 mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste;
(5) and (3) sterilization: placing the paste obtained in the step (4) in a container, and sterilizing at a high temperature of 140 ℃ for 40 s;
(6) filling: cooling to 38 deg.C, vacuum filling, and sealing;
(7) secondary sterilization: sterilizing for 20 minutes at 85 ℃ by using a sterilization kettle to prepare the finished product of the bowel relaxing ointment.
Functional test of animals
Small intestine propulsion experiment
1. Grouping and dose setting: 210 Kunming mice were taken and adaptively fed for 5 days, and then randomly divided into 21 groups of a normal control group, a model control group, a low dose group (0.5g/kg body weight), a high dose group (1.0g/kg body weight) and 17 prescription split groups (2.0g/kg body weight) according to body weight. The specific information of each group is as follows:
low dose group: example 1(0.5g/kg body weight);
high dose group: example 1(1.0g/kg body weight);
group A1: 10 parts of cistanche deserticola (2.0g/kg body weight);
group A2: 5 parts of fructus cannabis (2.0g/kg body weight);
group A3: 5 parts of dried orange peel (2.0g/kg body weight);
group A4: 5 parts of bunge cherry seeds (2.0g/kg of body weight);
group A5: 25 parts of black sesame (2.0g/kg body weight);
group A6: malt 10 parts (2.0g/kg body weight);
group A7: 10 parts of cistanche and 25 parts of black sesame (2.0g/kg of body weight);
group A8: 10 parts of cistanche and 5 parts of fructus cannabis (2.0g/kg of body weight);
group A9: 10 parts of cistanche and 5 parts of bunge cherry seeds (2.0g/kg of body weight);
group A10: 5 parts of bunge cherry seed and 5 parts of dried orange peel (2.0g/kg body weight);
group A11: 10 parts of cistanche, 5 parts of fructus cannabis and 5 parts of bunge cherry seed (2.0g/kg body weight);
group A12: 10 parts of cistanche, 5 parts of fructus cannabis and 5 parts of dried orange peel (2.0g/kg body weight);
group A13: 10 parts of cistanche, 25 parts of black sesame and 5 parts of fructus cannabis (2.0g/kg of body weight);
group A14: 10 parts of cistanche, 5 parts of bunge cherry seed and 10 parts of malt (2.0g/kg body weight);
group A15: 10 parts of cistanche, 25 parts of black sesame, 5 parts of fructus cannabis and 5 parts of bunge cherry seed (2.0g/kg of body weight);
group A16: 10 parts of cistanche, 25 parts of black sesame, 5 parts of fructus cannabis, 5 parts of bunge cherry seed and 5 parts of dried orange peel (2.0g/kg body weight);
group A17: 10 parts of cistanche, 25 parts of black sesame, 5 parts of fructus cannabis, 5 parts of bunge cherry seed and 10 parts of malt (2.0g/kg body weight);
2. model preparation and drug delivery: 10 mice in each group, during the test, the low-dose group, the high-dose group and each prescription group are respectively administered with the test substances according to the gavage of 20 ml/kg-bw, and the normal control group and the model control group are both administered with distilled water with the same volume by gavage for 1 time every day for 14 days continuously. After each group is fasted for 24 hours, the normal control group is given equal volume of distilled water, the other groups are respectively given compound diphenoxylate tablets (10mg/kg) by intragastric administration, a mouse constipation model is copied, and after 30min of model building, each group is respectively given ink (0.1ml/10g) by intragastric administration. The 20min later cervical vertebra dislocation method is sacrificed the animal, opens the abdominal cavity and separates mesentery, cuts the upper end from pylorus, lower extreme to the intestinal canal of returning the cecum, draws the small intestine into the straight line gently, measures intestinal canal length and is "small intestine total length", is "chinese ink propulsion length" from the pylorus to the chinese ink front edge, calculates the chinese ink propulsion rate:
ink propulsion rate (%) (ink propulsion length/total small intestine length) × 100%
The results are shown in table 1 below:
TABLE 1 Effect of samples on intestinal propulsive locomotion in Constipated mice
| Grouping | Ink push Rate (%) |
| Normal control group | 61.5±3.5 |
| Model control group | 35.8±4.1## |
| Low dose group | 59.2±2.9** |
| High dose group | 60.1±3.1** |
| Cistanche group | 36.9±5.2ΔΔ |
| Fructus cannabis group | 36.3±4.0ΔΔ |
| Dried orange peel group | 35.9±3.1ΔΔ |
| Chinese dwarf cherry seed group | 36.5±6.0ΔΔ |
| Black sesame group | 36.6±2.2ΔΔ |
| Malt group | 35.9±5.3ΔΔ |
| Cistanche and black sesame seed group | 38.2±3.9ΔΔ |
| Cistanche and fructus cannabis group | 38.5±2.0ΔΔ |
| Cistanche and bunge cherry seed group | 38.1±5.5ΔΔ |
| Semen Pruni + pericarpium Citri Tangerinae group | 37.9±6.2ΔΔ |
| Cistanche, fructus cannabis and bunge cherry seed group | 39.5±3.8ΔΔ |
| Cistanche, fructus cannabis and dried orange peel group | 39.3±5.0ΔΔ |
| Cistanche, fructus cannabis and black sesame seed group | 39.1±5.6ΔΔ |
| Fructus cannabis, bunge cherry seed and malt group | 39.4±3.7ΔΔ |
| Cistanche, fructus cannabis, bunge cherry seed and black sesame seed group | 39.9±2.5ΔΔ |
| Cistanche, fructus cannabis, bunge cherry seed, black sesame and dried orange peel group | 40.2±3.3ΔΔ |
| Cistanche, fructus cannabis, bunge cherry seed, black sesame and malt group | 40.5±1.9ΔΔ |
Note: compared with the normal control group,##p<0.01
p <0.01 in comparison to model groups
Compared with the low-dose group, the treatment was,ΔΔp<0.01
compared with a normal control group, the ink propulsion rate of the model group is obviously reduced (p is less than 0.01), and the success of molding is indicated. Compared with a model group, the ink propulsion rate of the sample low-dosage group and the sample high-dosage group is obviously increased, and the difference has very significant significance (p is less than 0.01), so that the sample can obviously improve the small intestine propulsion type peristalsis of a constipation mouse, and the small intestine propulsion effect of each square dismantling group on the constipation mouse is not obvious, and the statistical difference is not generated (p is more than 0.05). Compared with the low-dose group, the ink propulsion rate of each prescription group is obviously reduced (p is less than 0.01), which shows that the composition paste has the function of improving small intestine propulsion type peristalsis, and the effect is better than that of the prescription group.
Observation of clinical efficacy
1. Case selection: among 300 clinical volunteer patients with constipation, 180 male patients, 120 female patients, age group 18-60 years, and average age 39, all patients had no statistical difference in sex, age, and course of disease.
2. The evaluation standard of curative effect is as follows:
and (3) curing: defecation is performed for 1 time within 2 days, the stool quality is moist, the time for relieving is smooth, and no recurrence is caused in a short period;
the effect is shown: defecation within 3 days, the defecation quality is moist, and the defecation is not smooth;
the method has the following advantages: defecation within 3 to 4 days;
and (4) invalidation: no improvement in symptoms;
the total effective rate is (cure + show effect + effective)/total number of cases is multiplied by 100 percent
The taking method comprises the following steps: randomly dividing 300 patients into 4 groups, wherein each group comprises 75 patients, namely a treatment group A, a treatment group B, a treatment group C and a control group, and respectively taking the ointment prepared in the embodiments 1, 2 and 3 of the invention for the treatment group A, the treatment group B and the treatment group C, 2 times a day, 10g each time, one week of oral administration, and one week of treatment course; the control group is administered with Cistanchis herba oral liquid (national standard Z10910032 of Shuijihuang pharmaceutical industry, Gansu, Japan) for 1-2 times a day for one week.
3. The treatment results are shown in table 2:
TABLE 2 therapeutic results
| Group of | Number of people/person | Cure (rate) | Show effect | Is effective | Invalidation | Total effective rate (%) |
| Treatment of group A | 75 | 62(82.7％) | 3 | 4 | 6 | 92.0％ |
| Treatment of group B | 75 | 63(84.0％) | 5 | 2 | 5 | 93.3％ |
| Treatment of group C | 75 | 65(86.7％) | 4 | 3 | 3 | 96.0％ |
| Control group | 75 | 45(60.0％) | 4 | 5 | 21 | 72.0％ |
The test adopts the desert cistanche oral liquid for relaxing bowels as a control group, and the desert cistanche oral liquid for relaxing bowels has the function of relaxing bowel and is used for senile constipation and postpartum constipation. The cure rate of the traditional Chinese medicine preparation reaches more than 80.0%, the total effective rate reaches more than 90.0%, and is higher than the cure rate and the total effective rate of a control group, wherein the treatment effect of treating the group C is the best.
Typical cases
Case 1: when a certain Chinese medicament is taken, women feel dizzy, bad appetite, little tongue fur and thready and soft pulse, the patients feel smooth and defecate 2 days after taking the Chinese medicament in the embodiment 1 of the invention, continue to take for 1 week, and eat more vegetables and fruits in combination with proper motion, and then defecate is normal all the time and is cured.
Case 2: some people, male, 36 years old, have constipation for many years due to prolonged sitting and lack of exercise, combined with preference for spicy meat and fish. After 3 months in 2014, the traditional Chinese medicine disclosed by the embodiment 2 of the invention is taken, a large amount of stubborn stool is discharged next day, after one week, the discharged stool is moderate in hardness, and after one month, a habit of regularly discharging the stool every day is formed.
Case 3: when a certain plum is in 45 years old and the stool is hard to dry for 5 years and one row is taken in 4-6 days, the enema is taken to relieve constipation, and the symptoms are as follows: asthenia, dry mouth, sallow and lusterless complexion, dark and lusterless cheeks, aversion to cold, poor appetite, dry mouth, preference for cold drink, aggravation of symptoms in autumn and winter, dull tongue, white tongue coating, and wiry and thready pulse. The diagnosis refers to the deficient constipation with deficiency of both yin and yang and qi and blood, which can nourish yin, moisten dryness, tonify qi and nourish blood. After the traditional Chinese medicine of the embodiment 3 of the invention is taken for 2 days, the excrement is smooth, 2 days are one line, the mouth is dry and better, after the traditional Chinese medicine is continuously taken for one month, all symptoms disappear, the excrement is normal, one line is taken for one day, the face is ruddy, and the recovery is realized.
Claims (6)
1. A traditional Chinese medicine composition for treating constipation caused by kidney qi deficiency and body fluid depletion is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of cistanche, 25-35 parts of black sesame, 5-15 parts of fructus cannabis, 5-10 parts of bunge cherry seed, 5-10 parts of dried orange peel and 10-15 parts of malt;
the traditional Chinese medicine composition is prepared by the following steps:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, and sieving; pulverizing fructus Cannabis, and sieving;
(2) extraction: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water which is 8-12 times of the total amount of the medicinal materials, decocting and extracting for 1-3 times with water, each time for 1-3 hours, cooling the extracting solution, and filtering with a 200-400-mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni into the concentrated solution, heating with slow fire, stirring continuously, lifting the stirring rod to obtain medicinal liquid, hanging flag, and stopping heating to obtain pasty composition.
2. A medicament containing the traditional Chinese medicine composition of claim 1, which is characterized in that the traditional Chinese medicine composition is used as an effective component, and medically acceptable auxiliary materials are added to prepare a clinically acceptable dosage form.
3. The pharmaceutical formulation of claim 2, wherein said pharmaceutical formulation is in the form of a paste.
4. An ointment for treating constipation caused by kidney qi deficiency and body fluid depletion, which comprises the Chinese medicinal composition of claim 1.
5. The paste according to claim 4, characterized in that it is prepared by the following process: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water 8-12 times of the total amount of the medicinal materials, extracting for 1-3 times for 1-3 hours each time, cooling, filtering, and mixing filtrates; heating the filtrate to boil, concentrating with slow fire until the filtrate is concentrated to three fifths of the original filtrate volume, and stopping heating; adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste; sterilizing, packaging, and sterilizing for the second time to obtain final product for treating constipation caused by kidney qi deficiency and body fluid depletion.
6. A method for preparing the paste of claim 4, characterized by comprising the steps of:
(1) crushing: parching semen Sesami Niger and semen Pruni with slow fire, pulverizing into powder, and sieving; pulverizing fructus Cannabis, and sieving;
(2) extraction: cleaning cistanche, dried orange peel and malt with water, mixing, adding purified water which is 8-12 times of the total amount of the medicinal materials, extracting for 1-3 times, 1-3 hours each time, cooling the extracting solution, and filtering with a 200-400-mesh sieve;
(3) concentration: heating the filtrate to boiling, then using slow fire, continuously stirring and concentrating to three fifths of the original filtrate volume, stopping heating, and keeping the concentrated solution for later use;
(4) mixing and stirring: adding semen Sesami Niger, fructus Cannabis, and semen Pruni powder into the concentrated solution, heating with slow fire, stirring continuously until the stirring rod is lifted to obtain medicinal liquid and hung flag, and stopping heating to obtain paste;
(5) and (3) sterilization: sterilizing the paste obtained in the step (4) at a high temperature of 120-150 ℃ for 10-40 s;
(6) filling: cooling to 36-40 ℃, and filling and sealing by a vacuum filling machine;
(7) secondary sterilization: sterilizing for 15-30 minutes at 80-90 ℃ by using a sterilization kettle to prepare a finished product of the paste for treating constipation caused by kidney qi deficiency and body fluid depletion.
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| CN105998297A (en) * | 2016-08-09 | 2016-10-12 | 湖南知达医药科技有限公司 | Traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and preparation method thereof |
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| CN105998297A (en) * | 2016-08-09 | 2016-10-12 | 湖南知达医药科技有限公司 | Traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and preparation method thereof |
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