CN103212030B - Traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and preparation method thereof - Google Patents
Traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: akebiae fructus, rhizoma cyperi, szechwan chinaberry fruit, elecampane, cortex albiziae, algae, radix curcumae, green malt, radix paeoniae rubra, radix bupleuri, fructus aurantii, curcuma zedoary, pericarpium citri reticulatae viride, immature bitter orange, ligusticum wallichii, spina gleditsiae, thunberg fritillary bulb, tangerine leaf, fructus psoraleae and centipede. According to the treatment principle based on depression resolution and stasis dissolution, the traditional Chinese medicine provided by the invention is capable of well treating the liver depression type hyperplasia of mammary glands by using medicines which function in soothing the liver to resolve the depression, promoting the qi circulation to relieve the pain, relieving the stagnant qi to remove the qi stagnation and dissolving the phlegm to remove the stasis, so that the shackle that the traditional Western therapies such as traditional operations, antibiotics and the like only simply eliminate the lumps is broken, the defect of easy relapse is overcome, the defect that the Chinese patent drugs cannot suit the remedy to the case is overcome, and the advantages of strong pertinence, short course of treatment, rapid effect and difficult relapse are provided.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, relate in particular to a kind of Chinese medicine and preparation method for the treatment of liver energy stagnation type cyclomastopathy.
Background technology
According to World Health Organization (WHO), add up: 20～45 years old reproduction age female mammary gland proliferation sickness rate up to 50%, global cyclomastopathy patient surpasses 1,000,000,000, owing to lacking at present unified treatment standard and scientific and effective Therapeutic Method, the canceration rate of cyclomastopathy is growing, dies from every year nearly 200,000,000 people of women of cyclomastopathy.The international expert of breast disease association (SIS) the NGO particular study mechanism that calls upon States for a long time, and strengthen the input to curing mammary gland hyperplasia method and drug research, early settlement cyclomastopathy is cured a difficult problem.
Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.This disease sickness rate was the trend rising year by year in the last few years, and the age also more and more becomes younger.In adolescence or young women, premenstrual have distending pain of the breast, sometimes pain can involve shoulder back, through the spontaneous remission gradually of rear udder attachment pain, only can contact mammary gland and a bit thicken, without obvious tuberosity, these are that physiological changes, not disease, do not need treatment yet, belong to physiological hypertrophy.Cyclomastopathy is normal breast lobule physiological hypertrophy and subinvolution, and mammary gland normal configuration gets muddled, and belongs to pathological proliferation, it be neither inflammation a class of non-tumor is sick again.Be mainly in 30-50 year women, onset peak is 35-40 year.
At present, think that cyclomastopathy and endocrine disturbance and spirit, environmental factors etc. are relevant more.
1, endocrine disturbance.Lutein secretion reduces, and it is the major reason of cyclomastopathy morbidity that estrogen increases relatively.As unsound in the development of ovary, menoxenia, thyroid disease and hepatic insufficiency etc.
2. the impact of the Nervous and Mental Factors such as emotion.Psychentonia, the bad Nervous and Mental Factors such as excited easily form cyclomastopathy, and often stay up late, do not have enough sleep etc. also can be caused cyclomastopathy, and these undesirable elements also can increase the weight of existing cyclomastopathy symptom.
3. anthropic factor or bad life habits: the reasons such as sterile, sexual life imbalance at women advanced age, artificial abortion, man and wife's discord, not suckling, cause that mammary gland can not have normally, periodic physiological activity.Wear the medicated bra of tension or pass tight underwear etc.
4. dietary structure is unreasonable, as high fat, high-energy diet cause fat intake too much, drinks and the bad life habits such as smoking can be brought out breast disease.In addition, people's diet has been got well now, has the people of hypertension, hyperglycemia also a lot, and these also easily make women occur endocrine disturbance, cause cyclomastopathy.
5. long-term taking is containing estrogenic health product, contraceptive.The long-term excessive absorption estrogen of human body, will cause incretion balance imbalance, also contain hormone compositions in the feedstuff that some fast-growing food, artificial breeding's Aquatic product and poultry are used now more, and long-term eating also can cause the generation of mastopathy.
At present, doctor trained in Western medicine is to primary disease more perfect Therapeutic Method and the medicine of neither one also, mainly to adopt hormone to come treatment-resistant and surgical removal, conventional medicine has 5% potassium iodide and tamoxifen etc., pain severe patient can be tried out methyl testosterone or tamoxifen, generally need within menstruation the last week, start oral, in order to avoid further upset the trickle balance between human hormone, because primary disease is a chronic disease, Long-term Hormone class medicine, can only play analgesic effect, and side effect is large, if performed an operation, damage surface is large, cure the symptoms, not the disease, easily recurrence again, patient is difficult to accept, conventional medicine majority is Chinese patent medicine clinically, there is the effects such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, compensate qi and blood, therapeutic effect is also comparatively desirable, such as ease pill, little gold plaque, nodules of the breast ball, Xi Huan Wan, LIUWEI DIHUANG WAN, ERZHI WAN, XIAOJIN DAN, eliminating stagnation spirit, RUKUAIXIAO capsule, RUZENGNING PIAN, RUKUAIXIAO PIAN, eliminating stagnation nodules of the breast cream etc., but because Chinese patent medicine prescription and content are fixed, cannot suitably adjust composition or content in formula, cannot realize according to every patient's concrete condition and suiting the remedy to the case.
Cyclomastopathy can be subdivided into phlegm-damp type, liver energy stagnation type, blood-deficiency type and renal deficiency type again in the traditional Chinese medical science
Phlegm-damp type: patient's body is how fat, or many diseases, or asthenia is drowsiness, and some patient skin greases are more, obviously, or leucorrhea is many and slightly biased Huang for body odour, stool thickness and not smoothly, or often cough up phlegm, red tongue, tongue fur is slightly yellow thick, and during menstrual onset, breast has a dull ache.Treatment is worked as wet to reduce phlegm, loose breast and is become master.
Liver energy stagnation type: disease is seen menstruation time of tide in the future, distending pain of the breast, hypertrophy lobule pain is especially obvious, during anger distending pain of the breast more very, usually easily disgruntled, body of the tongue is partially dark and gloomy, or it is not good enough to sleep.It is main by resolving depression eliminating stagnation that treatment is worked as.
Blood-deficiency type: pale complexion is matt or sallow, fatigue and asthenia, lip, fingernail are light white, and menstruation color is light red, and while passing through, cyclomastopathy district has a dull ache, and pulse is thin and unable.Treatment is enriched blood eliminating stagnation as main when take.
Renal deficiency type: disease is seen soreness of the waist and knees, lower limb are weak, or tinnitus, night many urine, hyposexuality, forgetful, or clear and thin leucorrhea, during menstrual onset, breast has a dull ache, pale tongue, pulse heavy thin (slightly heavily can touch by the beginning with finger).Treatment is when becoming master with kidney reinforcing medicine powder.
So, Therapeutic Method and medicine with traditional western medical treatment method and single Chinese patent medicine, treat, can only play the effect of pain relieving and relief of symptoms in early days temporarily, can not tackle the problem at its root, thereby cause the outbreak repeatedly of disease, a chronic disease of easily examining refractory really of cyclomastopathy, but, as long as can seek a good method and good drug effect, can cure completely.Though disease one, method for the treatment of is different, although be both cyclomastopathy, but the clinical symptoms that every patient shows is also different, the individual difference of stopping is different, can not thousand people one sides, ten thousand people's one medicines, no matter Zhang San, Li Si is fixedly medication merely, effect is poor like this, not only control bad disease, easily recurrence on the contrary, must be according to the ultimate principle of differentiation of tcm when treatment primary disease, different characteristics in conjunction with patient's morbidity, adopt systematicness, personalized, the concrete concrete medication of the state of an illness, grasp best occasion for the treatment, science diagnosis, could find out accurately and effectively disease root like this, treatment targetedly, patient is avoided detours, spend less, reach a cure.
Summary of the invention
Technical problem to be solved by this invention is, utilize the traditional theory of Chinese medical science of China, a kind of Chinese medicine of novel treatment liver energy stagnation type cyclomastopathy is provided, according to take resolving depression eliminating stagnation as main Therapeutic Principle, medicine with dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot is well treated liver energy stagnation type cyclomastopathy, traditional western medicine therapies such as operation, antibiotic pure that breaks traditions is eliminated the yoke of lump, eliminates the defect of easily recurrence and overcomes Chinese patent medicine and can not realize the shortcoming of suiting the remedy to the case.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of liver energy stagnation type cyclomastopathy, wherein, described Chinese medicine comprises following raw medicinal material: Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Sargassum, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Chuanxiong, Spina Gleditsiae, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be preferably: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 70%～80% with determining alcohol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 3～5 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocts filtration 2～4 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decoct 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, standing 12～24 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
In order to solve the problems of the technologies described above, the present invention provides again a kind of preparation method of above-mentioned formula Chinese medicine, and the dosage form of described Chinese medicine is powder, and it comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
In order to solve the problems of the technologies described above, the present invention provides a kind of preparation method of above-mentioned formula Chinese medicine again, and the dosage form of described Chinese medicine is oral solutions, and it comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 70%～80% with determining alcohol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 3～5 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocts filtration 2～4 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decoct 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, standing 12～24 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
Beneficial effect of the present invention:
Chinese medicine provided by the invention, according to take resolving depression eliminating stagnation as main Therapeutic Principle, medicine with dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot is well treated liver energy stagnation type cyclomastopathy, traditional western medicine therapies such as operation, antibiotic pure that breaks traditions is eliminated the yoke of lump, the easy defect of recurrence and overcome Chinese patent medicine and can not realize the shortcoming of suiting the remedy to the case, pointed strong, short treating period, instant effect and be difficult for the advantage of recurrence.
The specific embodiment
The invention provides a kind of Chinese medicine for the treatment of liver energy stagnation type cyclomastopathy, it comprises: Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Sargassum, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Chuanxiong, Spina Gleditsiae, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra.
Wherein, Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Radix Bupleuri, Rhizoma Curcumae, Rhizoma Chuanxiong, Cortex Albiziae and Radix Curcumae liver-smoothing, qi-regulating, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, calming nerves and activating blood circulation; Fructus Aurantii, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy; Fructus Hordei Germinatus invigorating the spleen and regulating the stomach, soothing the liver circulation of qi promoting; Radix Paeoniae Rubra, Radix Bupleuri, Spina Gleditsiae dissipating blood stasis for subsidence of swelling; Sargassum, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra eliminating stagnation, expectorant; All medicines share, and realize the function of dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot.
Various raw medicinal material pharmacology are as follows:
Fructus Akebiae: the wooden ratan of plants of Lardizabalaceae threeleaf akebia Akebia trifoliata (Thunb.) Koidz..Bitter in the mouth, cold in nature; Return liver, spleen channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, costalgia, hernia, dysmenorrhea, uterus tenesmus.(< < Chinese medicine voluminous dictionary > >)
Rhizoma Cyperi: acrid in the mouth, micro-hardship, sweet, property is flat.Dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, regulates the flow of vital energy in tune.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.< < detailed outline > > carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers, separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.
Fructus Toosendan: claim again chinaberry reality, Fructus Toosendan, core Fructus Jujubae, Fructus Toosendan, chinaberry, the stone Fructus Evodiae, Fructus Toosendan tree, Fructus Toosendan reality etc.Cold in nature, bitter in the mouth; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Energy soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, return spleen, stomach, large intestine, liver, lung, tri-jiao channel, has promoting the circulation of QI to relieve pain, and the effect of strengthening the spleen to promote digestion cures mainly stagnation of QI in spleen and stomach card, dysentery tenesmus, the thoracic obstruction, object for appreciation abdominal distention and pain, food stagnation do not disappear, the cards such as anorexia.
Cortex Albiziae: be the dry bark of pulse family (LeguminOsae) plant Herba Albiziae.Another name: close confused skin (< < Qianjin Yao Fang > >), CORTEX ALBIZIAE (the < < side of walking alone > >), Herba Albiziae veneer (< < detailed outline > >).Sweet in the mouth, property are put down.GUIXIN, liver, lung meridian.Resolving stagnation for tranquilization, the eliminating carbuncle of invigorating blood circulation, reuniting the fractured tendons and bones.Cure mainly: irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury, blood stasis swells and ache etc.
Radix Curcumae: pungent, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, distending pain of the breast, calentura coma, epilepsy is gone mad, and heat in blood is told nosebleed, jaundice dark coloured urine.
Sargassum: be the dry frond of Sargassaceae plant Sargassum Sargassum pallidum (Turn.) C.Ag. or Sargassum fusiforme (Harv.) Setch Sargassum fusiforme (Harv.) Setch..The former practises title " compatibile ", and the latter practises title " lobule Sargassum ".Summer, Qiu Erji fish, and remove impurity, clean, and dry.Bitter in the mouth, one-tenth, cold in nature.Return liver, stomach, kidney channel.Hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema.
Fructus Hordei Germinatus: sweet, flat.Return spleen, stomach warp.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.For food stagnation, do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, women's ablactation.Fructus Hordei Germinatus: invigorating the spleen and regulating the stomach, soothing the liver circulation of qi promoting.For insufficiency of the spleen lack of appetite, milk smoulders.Fructus Hordei Germinatus (parched): promote qi circulation digestion promoting galactopoiesis.For food stagnation, do not disappear, women's ablactation.Fructus Hordei Germinatus (parched to brown): relieving dyspepsia.For food stagnation, do not disappear, abdominal distention.
Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For heat, enter nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, injury from falling down, carbuncle skin infection.
Radix Bupleuri: another name: Asia puecon recklessly, smoke < < Sheng Nong's herbal classic > >, mountain dish, eat careless < < WU Pu Bencao > >, faggot < < product converge essence and want > >.Cold nature, bitter in the mouth, pungent; GUIXIN bag, liver, gallbladder, tri-jiao channel.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For fever caused by exogenous pathogens, the diseases such as the internal organs prolapsus of collapse of QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.
Fructus Aurantii: bitter, pungent, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Rhizoma Curcumae: Rhizoma Curcumae original name Rhizoma Curcumae.Begin to carry < < property of medicine opinion > >, have another name called PengCurcuma Mao, paulin cowherb, fluffy art, Qiang seven, wide art, evil mind Rhizoma Zingiberis Recens, Rhizoma Curcumae, radix zedoariae, green Rhizoma Zingiberis Recens.Acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Cure mainly 1) removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is larger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.2) long-pending eliminating stagnation: the pain relieving of this product energy circulation of qi promoting removing food stagnancy, for eating accumulation, breast abdominal distention is vexed has a pain.3) removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.4) promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.
Pericarpium Citri Reticulatae Viride: bitter, pungent, temperature.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Fructus Aurantii Immaturus: bitter, pungent, sour, temperature.Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, the loose painful abdominal mass of reducing phlegm.In stagnant, stop, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Rhizoma Chuanxiong: pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Spina Gleditsiae: pungent, temperature.Return liver, stomach warp.Detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.
Bulbus Fritillariae Thunbergii: hardship, cold.Return lung, heart channel.Heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing, for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Folium Citri tangerinae: for the leaf of rutaceae orange Citrus reticulata Blanco, can adopt at any time, dry or using fresh herb.Hardship, flat.。For mastitis, hypochondriac pain.
Fructus Psoraleae: pungent, bitter, temperature.Return kidney, spleen channel.。For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Scolopendra: pungent, temperature; Poisonous.Return Liver Channel.。For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can be preferably: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
Wherein, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
When the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 70%～80% with determining alcohol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 3～5 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocts filtration 2～4 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decoct 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, standing 12～24 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
The present invention provides again a kind of preparation method of above-mentioned formula Chinese medicine, and the dosage form of described Chinese medicine is powder, and it comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
The present invention provides a kind of preparation method of above-mentioned formula Chinese medicine again, and the dosage form of described Chinese medicine is oral solutions, and it comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 70%～80% with determining alcohol is as solvent, adopt percolation with the speed of 1～3ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 3～5 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocts filtration 2～4 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 2～4 times of its quality, decoct 1～2 hour, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, standing 12～24 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 3～5 times of amounts of powder quality, the sucrose of 0.1～0.3 times, and the sodium benzoate of 0.01～0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1: powder 1 prepared by the present invention
The weight of the various raw medicinal materials in Chinese medicine is: Fructus Akebiae 30g, Rhizoma Cyperi 12g, Fructus Toosendan 25g, Radix Aucklandiae 22g, Cortex Albiziae 18g, Radix Curcumae 25g, Sargassum 32g, Fructus Hordei Germinatus 28g, Radix Paeoniae Rubra 14g, Radix Bupleuri 20g, Fructus Aurantii 16g, Rhizoma Curcumae 25g, Pericarpium Citri Reticulatae Viride 12g, Fructus Aurantii Immaturus 20g, Rhizoma Chuanxiong 12g, Spina Gleditsiae 10g, Bulbus Fritillariae Thunbergii 30g, Folium Citri tangerinae 16g, Fructus Psoraleae 28g and Scolopendra 10g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion above-mentioned raw materials medical material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 12 hours, and with slow fire boiling, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 3 hours, filters and obtains the second filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;
The 5th step, in the powder obtaining, adds starch in the 4th step, and the percentage by weight of starch in powder is 25%, and by the pouch subpackage of the material after mixing, every 10 grams is one bag.
Embodiment 2: powder 2 prepared by the present invention
The weight of the various raw medicinal materials in Chinese medicine is: Fructus Akebiae 35g, Rhizoma Cyperi 18g, Fructus Toosendan 20g, Radix Aucklandiae 20g, Cortex Albiziae 20g, Radix Curcumae 28g, Sargassum 36g, Fructus Hordei Germinatus 25g, Radix Paeoniae Rubra 12g, Radix Bupleuri 25g, Fructus Aurantii 18g, Rhizoma Curcumae 22g, Pericarpium Citri Reticulatae Viride 11g, Fructus Aurantii Immaturus 15g, Rhizoma Chuanxiong 15g, Spina Gleditsiae 14g, Bulbus Fritillariae Thunbergii 25g, Folium Citri tangerinae 12g, Fructus Psoraleae 25g and Scolopendra 12g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion above-mentioned raw materials medical material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 10 hours, and with slow fire boiling, decocting time is 4 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 3 hours, filters and obtains the second filtrate, and the quality of the water adding is 3 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 120 orders;
The 5th step, in the powder obtaining, adds starch in the 4th step, and the percentage by weight of starch in powder is 20%, and by the pouch subpackage of the material after mixing, every 10 grams is one bag.
Embodiment 3: oral solutions 1 prepared by the present invention
The weight of the various raw medicinal materials in Chinese medicine is: Fructus Akebiae 25g, Rhizoma Cyperi 13g, Fructus Toosendan 25g, Radix Aucklandiae 23g, Cortex Albiziae 20g, Radix Curcumae 30g, Sargassum 38g, Fructus Hordei Germinatus 26g, Radix Paeoniae Rubra 15g, Radix Bupleuri 22g, Fructus Aurantii 15g, Rhizoma Curcumae 26g, Pericarpium Citri Reticulatae Viride 10g, Fructus Aurantii Immaturus 23g, Rhizoma Chuanxiong 14g, Spina Gleditsiae 11g, Bulbus Fritillariae Thunbergii 29g, Folium Citri tangerinae 16g, Fructus Psoraleae 27g and Scolopendra 11g;
Its preparation method comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 80% with determining alcohol is as solvent, adopt percolation with the speed of 2ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 4 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 5 times of the powder qualities that obtain with respect to second step, decocts filtration 3 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 3 times of its quality, decoct 2 hours, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 95% ethanol, makes determining alcohol reach 70%～80%, standing 24 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 4 times of amounts of powder quality, the sucrose of 0.2 times, and the sodium benzoate of 0.01 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
Embodiment 4: oral solutions 2 prepared by the present invention
The weight of the various raw medicinal materials in Chinese medicine is: Fructus Akebiae 40g, Rhizoma Cyperi 22g, Fructus Toosendan 22g, Radix Aucklandiae 17g, Cortex Albiziae 23g, Radix Curcumae 27g, Sargassum 36g, Fructus Hordei Germinatus 34g, Radix Paeoniae Rubra 18g, Radix Bupleuri 24g, Fructus Aurantii 23g, Rhizoma Curcumae 14g, Pericarpium Citri Reticulatae Viride 14g, Fructus Aurantii Immaturus 31g, Rhizoma Chuanxiong 9g, Spina Gleditsiae 16g, Bulbus Fritillariae Thunbergii 24g, Folium Citri tangerinae 22g, Fructus Psoraleae 36g and Scolopendra 14g;
Its preparation method comprises the following steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, the methanol that is 75% with determining alcohol is as solvent, adopt percolation with the speed of 1ml per minute percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol adding is 5 times of first step mixture quality;
Second step, is mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, is ground into powder;
The 3rd step, adds the distilled water of 4 times of the powder qualities that obtain with respect to second step, decocts filtration 2 hours, obtain the first filtrate, filtering residue is added to the distilled water with respect to 3 times of its quality, decoct 1.5 hours, filter, obtain the second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is 90% ethanol, makes determining alcohol reach 70%～80%, standing 18 hours, filter concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
The 4th step, mixes the powder of second step and the acquisition of the 3rd step, adds the distilled water with respect to 3 times of amounts of powder quality, the sucrose of 0.1 times, and the sodium benzoate of 0.02 times, stirs, and boils, cooling, filter, subpackage, sterilizing obtains oral liquid.
Acute toxicity test
The powder 1 of preparing with the embodiment of the present invention 1 is, the oral solutions 1 of the powder 2 of embodiment 2 preparations, embodiment 3 preparations and the oral solutions 2 of embodiment 4 preparations, powder 1 and powder 2 are dissolved in respectively in distilled water, give respectively 4 groups of white mice feedings dispensings with 140 times, 200 times, 160 times of clinical consumption per day and 220 times, observe 7; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test
By the powder 1 of the embodiment of the present invention 1 preparation, 2 pairs of mices of powder of embodiment 2 preparations are by 7.81, 18.34 and 40.11g crude drug/kg be dissolved in water, 2 pairs of mices of oral solutions of the oral solutions 1 of the embodiment of the present invention 3 preparations and embodiment 4 preparations are pressed to 8.15, 19.25 and 40.34g crude drug/kg, 4 groups of mices are distinguished to continuous uses 12 weeks, every day 2 times, and drug withdrawal is after 4 weeks, result shows: the hair of Chinese medicine of the present invention to 4 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical data:
Outpatient's 127 examples of selecting liver energy stagnation type cyclomastopathy, are divided into two treatment groups and two matched groups according to random table method.
Treatment group one 37 examples, 24～49 years old age, average 35 years old; The course of disease 5 months～6 years, one-sided breast 17 examples of falling ill, bilateral breast 20 examples of falling ill;
Treatment group 2 33 examples, 22～48 years old age, average 34 years old; The course of disease 4 months～5 years, one-sided breast 14 examples of falling ill, bilateral breast 19 examples of falling ill;
Matched group one 29 examples, 22～50 years old age, average 36 years old, the course of disease 3 months～6 years, one-sided breast 13 examples of falling ill, bilateral breast 16 examples of falling ill;
Matched group 2 28 examples, 20～52 years old age, average 36 years old, the course of disease 6 months～7 years, one-sided breast 14 examples of falling ill, bilateral breast 14 examples of falling ill;
It is substantially similar that four groups of data distribute in age, the course of disease, the state of an illness, has comparability.
Diagnostic criteria is with reference to the diagnostic criteria of < < surgery > > cyclomastopathy: 1) pain appears in one-sided or bilateral breast, majority has periodically, show effect relevant with menstrual cycle, menstruation a few days ago pain increases the weight of, and alleviates or disappear after menstrual onset; 2) side or bilateral breast body of gland limitation or diffuse thickening are found in health check-up, and lump is graininess, not of uniform size, and matter is tough and not hard, and buildup area and the boundary of surrounding normal mammary gland tissue are unclear; 3) the primary disease course of disease is longer, and slower development is apt to occur in middle-aged women; 4) small number of patients can be associated with nipple discharge, is serosity or slurry courage and uprightness, if any above-mentioned two above persons, can confirm as primary disease.Utilize if desired the auxiliary detection means such as molybdenum target x line, B ultrasonic, thermal image figure, or the suction cytolgical examination of row lump pin and local living tissue pathologic finding, to get rid of other good, malignant diseases such as breast carcinoma, mammary gland fibroma.
The < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > that criterion of therapeutical effect is worked out according to the State Administration of Traditional Chinese Medicines drafts.Clinical cure: pain and lump all disappear, nipple is without discharge and maintain 6 months persons; Effective: pain disappears, and the lump thickening softens and scatters, and lump dwindles and is greater than 50%; Effective: pain is obviously alleviated, lump deliquescing, lump dwindles and is less than 50%; Invalid: pain is without alleviation, and lump size, quality are without change.
Therapeutic Method:
The powder agent medicine of the oral embodiment of the present invention 1 for the treatment of group one, morning every day, evening respectively take 1 time, each 2 bags.Within one month, be a course for the treatment of, take 2 courses for the treatment of.The irritable foods such as period in a medicine fasting is raw and cold, greasy, pungent.
The oral solutions medicine of the oral embodiment of the present invention 4 for the treatment of group two, morning every day, evening respectively take 1 time, each 15ml.Within one month, be a course for the treatment of, take 2 courses for the treatment of.The irritable food such as during applying medicinal lotion or ointment fasting is raw and cold, greasy, pungent.
Matched group one is taken 5% potassium iodide, and every day 3 times is oral, and each 10ml, 2 months is 1 course for the treatment of, takes 1 course for the treatment of.
Matched group two is taken Chinese patent medicine ease pill, and every day 2 times is oral, and each 10 1 month is 1 course for the treatment of, takes 2 courses for the treatment of.The irritable foods such as period in a medicine fasting is raw and cold, greasy, pungent.
Therapeutic outcome:
Treatment group one 37 examples, clinical cure 27 examples (73%), effective 5 examples (13.5%), effective 4 examples (10.8%), invalid 1 example (2.7%), total effective rate 97.3%; Check in 3-6 month after drug withdrawal, without recurrence.
Treatment group 2 33 examples, clinical cure 23 examples (69.7%), effective 4 examples (12.1%), effective 6 examples (15.2%), invalid 1 example (3%), total effective rate 97%; Check in 3-6 month after drug withdrawal, without recurrence.
Matched group one 29 examples, clinical cure 10 examples (34.5%), effective 5 examples (17.2%), effective 7 examples (24.1%), invalid 7 examples (24.1%), total effective rate 75.9%; Check in 3-6 month after drug withdrawal, recurrence 6 people, relapse rate 20.1%.
Matched group 2 28 examples, clinical cure 12 examples (42.9%), effective 7 examples (25%), effective 5 examples (17.9%), invalid 4 examples (14.3%), total effective rate 85.7%; Check in 3-6 month after drug withdrawal, recurrence 4 people, relapse rate 14.3%.
Through Ridit, analyze, treatment group curative effect is better than matched group (P < 0.05), adopts Chinese medicine of the present invention to treat, and its curative effect will be significantly better than matched group, and is difficult for recurrence.
In addition, the example of 27 in treatment group one is cured in patient, and 16 examples were cured in 1 month, and 11 examples were cured in 2nd month;
In treatment group two 23 example is cured in patient, and 14 examples were cured in 1 month, and 9 examples were cured in 2nd month; .
In matched group one 10 example is cured in patient, and 3 examples were cured in 1 month, and 7 examples were cured in 2nd month;
In matched group two 12 example is cured in patient, and 5 examples were cured in 1 month, and 7 examples were cured in 2nd month.
Known by foregoing, adopt Chinese medicine of the present invention to treat, its treatment time will be significantly shorter than the treatment time of matched group, treats the course for the treatment of shorter.
Model case:
Mrs Zhao, 29 years old.Before patient's readme half a year, found two breasts enclosed mass lump that all differs in size, at each menstrual cycle, carry out two mammary swellings pains of the time of tide, and enclosed mass has increase, through after pain disappearance, but enclosed mass only dwindles.When excited, when angry especially distending pain of the breast more very, irritability.The outer quadrant of the left and right breast enclosed mass that all differs in size, hard in matter, smooth surface, mobility is good, and tenderness is obvious.Bilateral breast skin is normal, and nipple is without depression and discharge.Ultrasound diagnosis: bilateral breast lobule fibroid hypertrophy.Ru Fang Molybdenum target x-ray checks: two cyclomastopathy.Gonadal hormone inspection is abnormal.Diagnosis: cyclomastopathy.Be judged to be the liver energy stagnation type cyclomastopathy that the traditional Chinese medical science is thought, take the powder of the embodiment of the present invention 1, morning every day, evening respectively take 1 time, each 2 bags, mixing in water for oral taking, the 2 weeks rear udder attachment pain reliefs of taking medicine, it is comparatively steady that emotion becomes, 4 weeks rear udder attachment pain and menstrual period distending pain obviously alleviate, anxious state of mind and body of the tongue take a favorable turn, and continue to take after 7 weeks, two swelling of the breast pieces and menstrual period pain all disappear,, B ultrasonic body of gland is clear, and gonadal hormone inspection is normal, all the other all diseases all disappear or are clearly better, continue to take after 1 week, all transference cures, follow up a case by regular visits to not recurrence in 1 year.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (5)
1. a Chinese medicine for the treatment of liver energy stagnation type cyclomastopathy, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
2. Chinese medicine as claimed in claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
3. Chinese medicine as claimed in claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine is: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
4. Chinese medicine as described in claims 1 to 3 any one, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
5. the preparation method of Chinese medicine as described in claims 1 to 3 any one, is characterized in that: the dosage form of described Chinese medicine is powder, and it comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains powder by the first step and adds in cold water and soak 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of the first step;
The 3rd step, the filtering residue that second step filter is obtained adds in cold water again, with slow fire boiling 2 hours～4 hours, filters and obtains the second filtrate, and the quality of the water adding is 2～4 times of the powder quality that obtains of second step;
The 4th step, the second filtrate that the first filtrate that second step is obtained and the 3rd step obtain is mixed, and concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80～120 orders;
The 5th step, in the powder obtaining, adds starch in described the 4th step, and the percentage by weight of described starch in described powder is 15%～30%, and by pouch or packing box subpackage for the material after mixing, every 5～10 grams is one bag or a box subpackage.
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