CN106176784B - It is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof - Google Patents

Abstract

The present invention discloses a kind of pharmaceutical composition for dermatitis, and composition component score meter by weight includes: 3~20 parts of matrine, 1~10 part of Osthole, momordin Ic2~15 part, 3~20 parts of Paeonol, 8~40 parts of glycyrrhizic acid, 10~48 parts of menthol, 5~30 parts of bisabolol；The present invention has antipruritic, antiinflammation, can be used for treating insect dermatitis, contact dermatitis, quick, short treating period, cure rate are high, easy to use, to skin without sensitization and irritation；It is mature preparation process, quality controllable.

Description

It is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicines fields, and in particular to a kind of for the pharmaceutical composition of dermatitis, application, preparation And preparation method thereof.

Background technique

Dermatitis is a kind of abbreviation of scytitis reaction, causes the complicated multiplicity of the factor of dermatitis.It can be divided into: contact skin Inflammation, insect bite dermatitis, neurodermatitis, daylight sunburn dermatitis, deramatitis medicamentosa, steroid dependent dermatitis etc..The usual cause of disease are as follows: Chronic disease infection, endocrine metabolism change, food, inhalation (inhalatio) allergy etc..Thus the common sympton caused has erythema, oedema, With papule, blister or exudation etc..

Wherein, contact dermatitis refers to because the skin caused by after skin or the certain extraneous morbid substances of mucosal contact is acute Inflammatory reaction can also be gradually transformed into chronic dermatitis.Primary sexual stimulus (such as strong acid, highly basic) and allergy can be divided (as moved Physical property, vegetalitas, chemically) two kinds.Contact dermatitis clinical manifestation is erythema, swelling, papule, blister, even bleb, clinic It is common that finding is caused a disease with chemical substance.Primary contact dermatitis is found in anyone, and allergy contact dermatitis is only sent out In a few peoples.The degree of dermatitis depends on the sensitization and reaction of the substance.Currently, the western medical treatment disease is generally adopted With oral Loratadine, such as cyproheptadine, imidazoles this fourth；Severe one can give glucocorticoid, such as oral prednisone, song Anxi dragon or dexamethasone, Diprospan intramuscular injection.That there are side effects is big for said medicine, therapeutic effect is poor, cure rate bottom It is insufficient.

Insect dermatitis is also known as lichen urticatus, acute simplex pruigo, has disease incidence height, acute pruritus, is easy again The characteristics of hair.Skin lesion often shows as round or shuttle shape wheal sample damage, and top can have the blister of syringe needle to mung bean size, dissipate Or cluster distribution.Majority morbidity and mosquito, flea lice etc. bite related, and patient is bitten rear animal saliva albumen and other polypides Albumen causes human body that allergic reaction occurs, to the symptoms such as itch, wheal, blister occur.Currently, the western medical treatment disease is mainly It is mostly steroids ointment using external ointment preparation.Hormone therapy has apparent non-specific inhibiting effect, though after external application The state of an illness can be made to improve rapidly, but it is short-term relief symptom, inhibit inflammatory reaction, rather than cure inflammation, it cannot be from basic The upper treatment cause of disease.The abuse of hormone, it is also possible to lead to steroid dependent dermatitis.Treatment papular urticaria also uses external application Various anti-itching lotions, if volume fraction is 1%~2% carbolic acid calamine lotion, compound alum lotion, dyclonine emulsion Deng antihistaminic, vitamin C for oral administration.It is easy that patient is made to generate drug dependence during treating rash, and easy to recur.

Summary of the invention

In view of this, the application provide it is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof, institute Medicine composite for curing contact dermatitis and papular significant in efficacy, healing height are stated, it is natural mild, it can be used for a long time.

In order to solve the above technical problems, technical solution provided by the invention is a kind of pharmaceutical composition, and the component is by weight Amount score meter includes: 3-20 parts of matrine, 1~10 part of Osthole, momordin Ic2~15 part, 3-20 parts of Paeonol, sweet 8~40 parts of oxalic acid, 10~48 parts of menthol, 5~30 parts of bisabolol.

Preferably, component score meter by weight includes: 5~15 parts of matrine, 1~6 part of Osthole, fruit of summer cypress soap Glycosides Ic2~10 part, 5~15 parts of Paeonol, 15~30 parts of glycyrrhizic acid, 25~45 parts of menthol, 8~25 parts of bisabolol

Preferably, component score meter by weight includes: 9 parts of matrine, 3 parts of Osthole, momordin Ic6 Part, 9 parts of Paeonol, 24 parts of glycyrrhizic acid, 36 parts of menthol, 15 parts of bisabolol.

Preferably, the raw material of the composition is kuh-seng, frutus cnidii, the fruit of summer cypress, cortex moutan, Radix Glycyrrhizae, menthol, opopanax Alcohol.

Preferably, the matrine is the extract of the kuh-seng, and the Osthole is the extract of the frutus cnidii, The momordin Ic is the extract of the fruit of summer cypress, and the Paeonol is the extract of the cortex moutan, the Radix Glycyrrhizae Acid is the extract of the Radix Glycyrrhizae.

Preferably, the matrine is the kuh-seng through water or alcohol steep, and filtrate is collected by filtration, extract obtained；Institute Stating Osthole is the frutus cnidii through water or alcohol steep, and filtrate is collected by filtration, extract obtained；The momordin Ic It is the fruit of summer cypress through water or alcohol steep, filtrate is collected by filtration, it is extract obtained；The Paeonol is the cortex moutan through water Or alcohol steep, filtrate is collected by filtration, it is extract obtained；The glycyrrhizic acid is the Radix Glycyrrhizae through water or alcohol steep, and filtering is received Collect filtrate, it is extract obtained.

Preferably, impregnated in the ethyl alcohol that it is 60~95% through water or volume fraction that the matrine, which is the kuh-seng, 1h~ Filtrate is collected by filtration in 5d, extract obtained；It through water or volume fraction is 60~95% that the Osthole, which is the frutus cnidii, 1h~5d is impregnated in ethyl alcohol, and filtrate is collected by filtration, it is extract obtained；The momordin Ic is the fruit of summer cypress through water or body 1h~5d is impregnated in the ethyl alcohol that fraction is 60~95%, and filtrate is collected by filtration, it is extract obtained；The Paeonol is described male 1h~5d is impregnated in the ethyl alcohol that the root bark of tree peony is 60~95% through water or volume fraction, filtrate is collected by filtration, it is extract obtained；It is described sweet 1h~5d is impregnated in the ethyl alcohol that it is 60~95% through water or volume fraction that oxalic acid, which is the Radix Glycyrrhizae, filtrate is collected by filtration, gained mentions Take object.

Preferably, the matrine is to take kuh-seng, is added ethyl alcohol, the kuh-seng and the ethyl alcohol volume ratio be 1:(3~ 18), room temperature immersion 1~5 time, 10~40 hours every time.The ethyl alcohol is recycled, is diluted with water and with dilute tune pH3~4, ether is washed It washs 1~5 time, isolates the ether, surplus solution tune pH11~15, the methylene chloride that 1~2 times of volume is added extracts biology Alkali.The methylene chloride is recycled, residue is dissolved in a small amount of chloroform.Then the ether of 5~15 times of volumes is added, places, filters, filter Liquid is evaporated, and petroleum ether is added, and 30 DEG C~60 DEG C refluxing extractions recycle the petroleum ether, filtering, remaining mother liquor concentrations, crystallization, It is extract obtained.

Preferably, the Osthole is taken frutus cnidii, and the ethyl alcohol that volume fraction is 60~95%, the frutus cnidii is added It is 1:(3~18 with the ethyl alcohol volume ratio), a large amount of white flock precipitates are precipitated into extracting solution for filtering, placement, filter, dense Contracting, then filter, it is concentrated into no alcohol taste, diatomite is added to stir, is successively extracted with petroleum ether, chloroform, ethyl acetate, is merged and extract Liquid is placed and crystallization is precipitated, extract obtained.

Preferably, the momordin Ic is to take the fruit of summer cypress, and the ethyl alcohol that volume fraction is 60~95%, the snake is added Machine tool and the ethyl alcohol volume ratio are 1:(5~20), 75~90 DEG C low-temperature heat refluxing extraction 3~5 hours, extracting solution is with 2500 The speed centrifugal treating of~3500rmin-1 10~20 minutes, takes supernatant to be concentrated under reduced pressure into no alcohol taste.Appropriate distillation is added Water, it is 18~30 hours arranged below in 10 DEG C, then with speed centrifugal treating 10~20 minutes of 2500~3500rmin-1, on After clear liquid petroleum ether extraction degreasing, the extracting n-butyl alcohol being saturated with water recycles the n-butanol, extract obtained.

Preferably, the Paeonol is to take cortex moutan, adds water, the cortex moutan and the water volume ratio be 1:(10~ 25), adding volume fraction is 2~10% sodium chloride, and temperature leaching 1~3 hour is distilled, distillate refrigerated overnight, and filtration obtains crystalline solid, Filtrate adds the sodium chloride again, and recrystallization must crystallize.Merge front and back gained crystallization twice, dry, gained.

Preferably, the glycyrrhizic acid is extracting liquorice, adds water, and the Radix Glycyrrhizae and the water volume ratio are 1:(3~10), it boils Boiling, repetition extraction 2~5 times, 1~2 hour every time, combined extract.Recycling design adds sulfuric acid, and brown precipitate is precipitated, and washes, Dry, milling is extract obtained.

Preferably, the glycyrrhizic acid is extracting liquorice, and adding volume fraction is 0.5~1.0% ammonium hydroxide, the Radix Glycyrrhizae and the ammonia Water volume ratio is 1:(5~20), refluxing extraction 2~5 times, filtering, merging filtrate.Adding volume fraction is 60~95% ethyl alcohol, quiet It sets overnight, filtering, filtrate is concentrated and cools down, and pH2~3 are adjusted after cooling, are precipitated, centrifugation, 50 DEG C~60 DEG C dryings.It is thick after drying Body object is soluble in water, adjusts pH6.4~7.4, crosses AB-8 resin, filters, and eluent is collected in elution, is concentrated, and decoloration, gained extracts Object.

Preferably, it is calculated by dry product, in the shrubby sophora extract, matrine mass fraction >=98.0%；By dry product It calculates, in the common cnidium fruit P.E, Osthole mass fraction >=95.0%；It is calculated by dry product, the fruit of summer cypress In extract, momordin Ic mass fraction >=87.0%；It calculates by dry product, in the Cortex Moutan extract, presses Dry product calculates, Paeonol mass fraction >=98.0%；It is calculated by dry product, in the licorice, the Radix Glycyrrhizae Acid mass fraction >=98.0%.

Preferably, the raw material includes: 100~500 parts of kuh-seng, 50~400 parts of frutus cnidii, the fruit of summer cypress according to parts by weight 50~400 parts, 150~1000 parts of cortex moutan, 200~2000 parts of Radix Glycyrrhizae, 10~48 parts of menthol, 5~30 parts of bisabolol.

Preferably, the raw material includes: 150~450 parts of kuh-seng, 100~350 parts of frutus cnidii, summer cypress according to parts by weight Sub 100~350 parts, 250~900 parts of cortex moutan, 400~1900 parts of Radix Glycyrrhizae, 25~45 parts of menthol, 8~25 parts of bisabolol.

Preferably, the raw material includes: 200~400 parts of kuh-seng, 150~300 parts of frutus cnidii, summer cypress according to parts by weight Sub 150~300 parts, 300~850 parts of cortex moutan, 500~1800 parts of Radix Glycyrrhizae, 30~42 parts of menthol, bisabolol 10~20 Part.

Preferably, the raw material according to parts by weight include: 360 parts of kuh-seng, it is 225 parts of frutus cnidii, 225 parts of the fruit of summer cypress, male 600 parts of the root bark of tree peony, 1200 parts of Radix Glycyrrhizae, 36 parts of menthol, 15 parts of bisabolol.

The present invention also provides a kind of application of composition in the drug of preparation treatment dermatitis.

Preferably, the dermatitis is insect dermatitis, contact dermatitis.

The present invention also provides a kind of drug combination preparation for dermatitis, by the composition and pharmaceutically acceptable Auxiliary material be made.

Preferably, the dosage form be gel, it is tablet, capsule, granule, pill, oral solution, a kind of or more in plaster Kind.

Preferably, the dosage form is gel.

Preferably, matrine mass percent in the gel is 0.1%~6.0%；Osthole is described Mass percent is 0.05%~5.0% in gel；Momordin in the gel mass percent be Ic0.1%~ 5.0%；Paeonol mass percent in the gel is 0.1~6.0%；Glycyrrhizic acid extract quality hundred in the gel Divide than being 0.1~10.0%；Menthol mass percent in the gel is 0.2%~2.0%；Bisabolol is described solidifying Mass percent is 0.1~8.0% in glue.

Preferably, matrine mass percent in the gel is 0.1%~3.0%；Osthole is described Mass percent is 0.05%~2.0% in gel；Momordin in the gel mass percent be Ic0.1%~ 2.0%；Paeonol mass percent in the gel is 0.1%~3.0%；Glycyrrhizic acid extract quality in the gel Percentage is 0.1%~8.0%；Menthol mass percent in the gel is 0.2%~1.8%；Bisabolol is in institute Stating mass percent in gel is 0.1%~4.0%.

Preferably, matrine mass percent in the gel is 0.3%；Osthole matter in the gel Measuring percentage is 0.1%；Momordin mass percent in the gel is Ic 0.2%；Paeonol is in the gel Mass percent is 0.3%；Glycyrrhizic acid extract mass percent in the gel is 0.8%；Menthol is in the gel Middle mass percent is 1.2%；Bisabolol mass percent in the gel is 0.5%.

The present invention also provides a kind of application of composite preparation in the drug of preparation treatment dermatitis.

Preferably, the dermatitis is insect dermatitis, contact dermatitis.

The present invention also provides a kind of preparation methods of pharmaceutical composition for dermatitis, in parts by weight, by kuh-seng 5~15 parts of alkali, 1~6 part of Osthole, momordin Ic2~10 part, 5-15 parts of Paeonol, 15~30 parts of glycyrrhizic acid, peppermint 25~45 parts of alcohol, 8~25 parts of bisabolol, mix in a solvent, obtain the composition.

Preferably, the solvent is ethyl alcohol.

Preferably, the ethyl alcohol is dehydrated alcohol.

Preferably, the ethyl alcohol is the ethyl alcohol that volume fraction is 95%.

Preferably, the present invention in parts by weight in gram.

In herein described technical solution:

Matrine: being a kind of alkaloid extracted by the root, stem, fruit of leguminous plant kuh-seng through organic solvents such as ethyl alcohol, Belong to the derivative lupin alkaloids of quinolizidine kind；It is dissolved in cold water, ethyl alcohol, ether, chloroform and benzene, is insoluble in petroleum Ether, solubility ratio is small in cold water in the hot water；There is antibacterial, relieving asthma, the multiple pharmacological effects such as increasing leucocyte.

Osthole: being a kind of substance extracted from the fruit of Umbelliferae annual herb plant frutus cnidii, outside It sees as yellow green to white crystalline powder；Not soluble in water and cold petroleum ether is soluble in acetone, methanol, ethyl alcohol, chloroform, three chloromethanes Alkane, ethyl acetate dissolve in the petroleum ether of boiling；Chemical name is osthole；With spasmolysis, drop Blood pressure, anti-arrhythmia, enhancing immune function and broad-spectrum antibacterial action.

Momordin Ic: for Chenopodiaceae annual herb plant the fruit of summer cypress Kochia scoparia (L.) Schrad at Ripe fruit；Belong to triterpene saponin；With clearing heat and promoting diuresis, dispelling wind and arresting itching and other effects.

Paeonol: can be made by extracting in Chinese medicine cortex moutan and Chinese medicine paniculate swallowwort, can also chemical synthesis；Chemical name is 2- Hydroxyl -4- methoxyacetophenone；Paeonol；2'- hydroxyl -4'- methoxyacetophenone；Become with analgesia, anti-inflammatory, antipyretic and inhibition The effect of state reaction；To pain caused by the physical or chemical factories such as pressure tail, acetic acid, there is apparent analgesic activity；To by angle Inflammatory reaction caused by dish glue, egg white, formaldehyde, histamine, serotonin, bradykinin, dimethylbenzene and endotoxin etc. is pitched, is had bright Aobvious inhibiting effect；Body temperature caused by typhoid vaccine, triple vaccine etc. is increased, there is apparent refrigeration function.To II, III, IV allergic reaction type all has inhibiting effect.

Glycyrrhizic acid: being most important active constituent in Radix Glycyrrhizae derived from the root and rhizome of glycyrrhizic legume；White is to micro- Huang Color crystalline powder, without smell, special sweet taste is extracted from liquorice root；Chemical name be (3 β, 20 β) positive olive -12- alkene -3- base -2-O- β-D- glycopyranosyl-α-D- glucopyranose the aldehyde of -20- carboxyl -11- oxo -30- Acid；Glycyrrhizic acid has the effects that anti-inflammatory, antiviral and protecting liver and detoxication and enhancing immune function；Glycyrrhizic acid swashs with adrenal cortex Plain sample effect, can inhibit capillary permeability, mitigate the symptom of anaphylactic shock, since glycyrrhizic acid has glucocorticoid sample medicine Reason is acted on without serious adverse reaction, also has the function of anti-cancer and cancer-preventing, interferon inducers and cell immunomodulator etc..

Menthol: Lamiaceae plant peppermint Mentho haplocalyx Bing is derived from) herb, herba lysimachiae Glechoma Longituba (Nakai) Kupr. herb, sharp purple perilla Perilla frutescens (L.) Britt.var.Acuto (Thunb.) Kudo leaf.Chemical name: [1R- (1 α, 2 β, 5 α)] -5- methyl -2- (1- Methylethyl) cyclohexanol；Mentholum；Terpene alcohol-[3]； To alkane -3- alcohol；[1R- (1A, 2B, 5A)] -5- methyl -2- (1- Methylethyl)；2- isopropyl -5- methyl cyclohexanol.Effect: make For skin or mucous membrane, there is refrigerant itching-relieving action；It is for oral administration to can be used for headache and nose, pharynx, laryngitis etc..

Bisabolol: being to be present in one of yellow chamomile composition, is a kind of monocyclic sesquiterpene alcohol, chemical name: α- 4- dimethyl ester-α-(4- methyl esters -3- pentane alcohol) -3- cycloheptanone -1- methanol；Α-bisabolol；Bisabolol, Α -4- diformazan Ester-Α-(4- methyl esters -3- pentane alcohol) -3- cycloheptanone -1- methanol；Bisabolol [terpene] alcohol；Bisabolence terpene alcohol；6- methyl -2- (4- methyl -3- cyclohexene -1- base) -5- heptene -2- alcohol.Effect: it is anti-inflammatory, promote wound healing, anti-microbial effect.

Kuh-seng: for the root of the perennial fallen leaves semishrub plant's kuh-seng Sophora flavescens Ait. of pulse family.Nature and flavor: It is bitter, cold in nature.Return liver, kidney, large intestine, small intestine, bladder, the heart channel of Hang-Shaoyin.Effect: heat-clearing and damp-drying drug；Wind dispelling insecticide.Main damp-heat dysentery；Intestines wind is just Blood；Jaundice；Difficult urination；Oedema；Leukorrhagia；Pruritus vulvae；Scabies；Leprosy；Pruitus；Wet poison sore.Matrine have it is anti-inflammatory, resist Allergy, immunological regulation, anti-virus sterilizing, calmness, it is antipruritic, it is antipyretic, the effects of cooling

Frutus cnidii: for the dry mature fruit of umbelliferae cnidium monnieri Cnidium monnieri (L.) Cuss..Property

Taste: acrid, bitter, warm.Return kidney channel.Effect: warming kidney and enhancing body, eliminating dampness, wind-dispelling, desinsection.For impotence, palace cold, cold-dampness band Under, arthritis with fixed pain caused by dampness pain in the loins；Eczema of vulva, married woman's pruritus vulvae are controlled outside；Trichomonas vaginitis.

The fruit of summer cypress: for the dry mature fruit of chenopod summer cypress Kochia scoparia (L.) Schrad..Nature and flavor: It is pungent, bitter, it trembles with fear.Return kidney, bladder meridian.Effect: clearing heat and promoting diuresis, dispelling wind and arresting itching.For difficulty and pain in micturition, pruritus vulvae leukorrhagia, rubeola, eczema, Pruitus.

Cortex moutan: for the dry root skin of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: it is bitter, It is cool.Return heart, liver, kidney, lung channel.Effect: clearing heat and cooling blood, promoting blood circulation to remove blood stasis.

Radix Glycyrrhizae: for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., swollen fruit The root and rhizome of Radix Glycyrrhizae G.inflata Bat. or glycyrrhiza glabra G.glabra L..Nature and flavor: sweet and neutral.Returns spleen, stomach, lung channel.Function Effect: invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；Moistening lung to arrest cough；Purging fire for removing toxin；Coordinating the drug actions of a prescription.

Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza The drying root and rhizome of inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L..It spring, the excavation of two season of autumn, removes Fibrous root dries.Nature and flavor: sweet and neutral.Enter spleen, heart stomach, lung channel, enters sufficient negative, lunar, shaoyin channel of fainting.Effect: invigorating the spleen and benefiting qi, heat-clearing solution Poison, expelling phlegm and arresting coughing, clear throat, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, phlegm of coughing More, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.

Compared with prior art, detailed description are as follows by the application: clinical drug use of the present invention shows to have the following advantages:

(1) Chinese herbal medicine selected by the present invention meets Pharmacopoeia of the People's Republic of China regulation, and according to compatibility, prescription is closed It manages, select medicine superior, to skin without sensitization and irritation, without essence pigment is natural mild, can be used for a long time, formula is suitable for Infant and adult；

(2) present invention has antipruritic, antiinflammation, provides for treatment dermatitis especially contact dermatitis with insect dermatitis A kind of new composition and its preparation, and quick, short treating period, cure rate it is high, it is easy to use, easily received by patient；

(3) mature preparation process of the present invention, quality controllable；

Specific embodiment

The invention discloses a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof, art technology Personnel can use for reference present disclosure, be suitably modified realization of process parameters.In particular, it should be pointed out that all similar replacements and changing Move apparent to those skilled in the art, they are considered as being included in the present invention.It method of the invention and answers With being described by preferred embodiment, related personnel can obviously not depart from the content of present invention, in spirit and scope To method described herein and application is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.

Below with reference to embodiment, the present invention is further explained:

Embodiment 1

The present invention provides the preparation method of a kind of described pharmaceutical composition and the composition gels, the composition component By weight score meter include: 9 parts of matrine, 3 parts of Osthole, Ic6 parts of momordin, 9 parts of Paeonol, 24 parts of glycyrrhizic acid, 36 parts of menthol, 15 parts of bisabolol；Parts by weight are in gram；

1, said components are dissolved in appropriate dehydrated alcohol, clear solution is made, obtain the composition；

2, the clear solution is mixed simultaneously with 55-70 DEG C of 1050 parts of PEG-50 rilanit specials, nonyl phenol polyethers -14 Stirring, obtains being emulsified agent and is rolled into transparent oil；

3, it after 5 parts of carbomer ingredients being soaked to propylene glycol and distilled water, places, so that carbomer is sufficiently swollen, is formed Aquation colloid；

4, the transparent oil in step 2) is uniformly mixed with distilled water, forms watery stablizing solution；

5, the aquation colloid while stirring, the aqueous stabilizing solutions in step 4) being slowly added into step 3) In, 3000 parts of gelatinous mixtures are made；

6, in colloidal mixture, it is 6.5 that triethanolamine modulation pH value, which is added, and uniform gel to get.

Embodiment 2~5

The present embodiment 2~5 the difference from embodiment 1 is that: described pharmaceutical composition component formula is shown in Table 1.

The pharmaceutical composition component formula of the present invention of table 1

Embodiment 6~12

The raw material that the composition of the present invention of embodiment 6 uses is kuh-seng, frutus cnidii, the fruit of summer cypress, cortex moutan, Radix Glycyrrhizae, thin Lotus alcohol, bisabolol；Wherein, the Osthole, the momordin Ic, the Paeonol, the glycyrrhizic acid are respectively The kuh-seng, the frutus cnidii, the fruit of summer cypress, the cortex moutan, the Radix Glycyrrhizae extract, parts by weight in gram, institute It states composition of raw materials and is shown in Table 2.

The pharmaceutical composition composition of raw materials of the present invention of table 2

Embodiment 13

The extracting method of pharmaceutical composition component of the present invention are as follows:

It taking kuh-seng medicine materical crude slice, is added ethyl alcohol, the kuh-seng medicine materical crude slice and the ethyl alcohol volume ratio are 1:8, room temperature immersion 3 times, often Secondary 24 hours.The ethyl alcohol is recycled, is diluted with water and with dilute tune pH3~4, ether washs 2 times, isolates the ether, remaining Solution adds NaOH tune pH12~14, and the methylene chloride that 1 times of volume is added extracts alkaloid.Recycle the methylene chloride, residue It is dissolved in a small amount of chloroform.Then the ether of 10 times of volumes is added, places, filtering, filtrate is evaporated, and petroleum ether is added, and 30 DEG C~60 DEG C refluxing extraction, recycles the petroleum ether, filters, and remaining mother liquor concentrations, crystallization obtains extract；

Frutus cnidii medicine materical crude slice is taken, it is the ethyl alcohol that volume fraction is 95%, the frutus cnidii medicine materical crude slice and the ethyl alcohol that concentration, which is added, Volume ratio is 1:8, and a large amount of white flock precipitates are precipitated into extracting solution for filtering, placement, is filtered, concentration, then is filtered, and nothing is concentrated into Alcohol taste adds diatomite to stir, and is successively extracted with petroleum ether, chloroform, ethyl acetate, and combined extract places and crystallization is precipitated, obtains Extract；

Fruit of summer cypress medicine materical crude slice coarse powder is taken, it is that isometric volume fraction is 95% ethyl alcohol and volume fraction is 75% that concentration, which is added, Ethyl alcohol, the frutus cnidii medicine materical crude slice and the ethyl alcohol total volume ratio are 1:10,85 DEG C low-temperature heat refluxing extraction 4 hours, extracting solution With 3000rmin^-1Speed centrifugal treating 15 minutes, take supernatant to be concentrated under reduced pressure into no alcohol taste.Appropriate distilled water is added, in 10 DEG C 24 hours arranged below, then with 3000rmin^-1Speed centrifugal treating 15 minutes, supernatant petroleum ether extraction degreasing Afterwards, the extracting n-butyl alcohol being saturated with water recycles the n-butanol, obtains extract；

Cortex moutan medicine materical crude slice is taken, water is added, the cortex moutan medicine materical crude slice and the water volume ratio are 1:15, and adding volume fraction is 5% Sodium chloride, temperature leaching 2 hours, distillation, distillate refrigerated overnight, filtration obtain crystalline solid, and filtrate adds the sodium chloride again, recrystallization, It must crystallize.Merge the front and back clean crystalline substance of gained twice, it is dry, obtain extract；

Extracting liquorice medicine materical crude slice coarse powder adds water, and the licorice piece coarse powder and the water volume ratio are 1:6, are boiled, and repeat to extract 6 times, 1 hour every time, combined extract.Brown precipitate is precipitated in recycling design to original volume one third, enriching sulfuric acid, washes, 60 DEG C of following temperature are dry, and milling obtains extract.

Embodiment 14

The present embodiment and the difference of embodiment 13 are: the glycyrrhizic acid is extracting liquorice medicine materical crude slice coarse powder, adds the volume fraction to be 0.5% ammonium hydroxide, the licorice piece coarse powder and the ammonium hydroxide volume ratio are 1:10, refluxing extraction 2 times, are filtered, merging filtrate.Add Volume fraction is 95% ethyl alcohol, is stood overnight, and is filtered, and filtrate be concentrated and cool down, add after cooling down the sulfuric acid tune pH2 of 3.5mol/L~ 3, it precipitates, centrifugation, 50 DEG C~60 DEG C dryings.Runic object after drying is soluble in water, adjusts pH6.4~7.4, crosses AB-8 resin, according to It is secondary to use water, ethanol elution, alcohol eluen, concentration are collected, active carbon decoloring obtains extract.

Embodiment 15

Anti-inflammatory experiment (Inhibition test that paraxylene of the present invention causes mice auricle swelling)

1, medicament:

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is 1~5 respectively；

1.2 positive controls: commercially available Fluonex.2, animal: KM (Kunming kind) mouse is big by Chengdu traditional Chinese medicine Experimental Animal Center is learned to provide.

3, experimental method: healthy mice 70 for selecting 18-22g of weight, all-male is randomly divided into 7 groups by weight, specifically It is divided into blank control group, 1~experimental group of experimental group 5, positive controls.It is administered by table 3, every group of mouse right ear embrocates medical fluid, often Secondary 0.1mL, 2 times a day, every group of mouse right ear continuous 4 days, 30min after last coating, is smeared dimethylbenzene by each 1 time of upper and lower noon 50 μ L cause inflammation, carry out test processes after causing inflammation 50min.

4, experimental result: swelling and inhibiting rate are calculated, the results are shown in Table 3.

The inhibition assay result of the paraxylene of the present invention of table 3 cause mice auricle swelling

Grouping	Number of animals (only)	Medicament	Swelling (mg)	Inhibiting rate (%)
					Blank control group	10	Distilled water	34.30±12.65	—
Experimental group 1	10	Embodiment 1	18.80±5.56	45.19
					Experimental group 2	10	Embodiment 2	14.80±6.76	56.85
Experimental group 3	10	Embodiment 3	18.60±7.70	45.77
					Experimental group 4	10	Embodiment 4	16.80±5.46	51.02
Experimental group 5	10	Embodiment 5	19.80±6.55	42.27
					Positive controls	10	Fluocet	9.20±1.70	73.18

As can be seen from the above table, real 1~experimental group of experimental group, 5 paraxylene causes mice auricle swelling to have inhibition well Effect, positive controls, although its inhibiting rate is higher, positive controls medicament Fluocet is hormone ointment, is Accordance with tolerance therapeutant has a side effect to children's use, be used for a long time easily occur dependence facial dermatitis and local pigment it is calm, The symptoms such as crinosity.And the application will not generate dependence without hormone using pure Chinese medicine component, be free from side effects.

The anti-inflammatory experiment of embodiment 16 (Inhibition test that the present invention causes rat paw edema to carrageenan)

1, medicament:

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is A~E respectively.；

1.2 positive controls: commercially available Fluonex.

2, animal: SD rat is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.

3, experimental method: healthy rat 70 for selecting 120-180g of weight, all-male are randomly divided into 7 groups by weight, tool Body is divided into blank control group, experimental group A~experimental group E, positive controls.It is administered by table 4, the right vola pedis painting of every group of mouse is applied medicinal lotion or ointment Liquid, each 0.1mL, 2 times a day, and each 1 time of upper and lower noon, continuous 4 days, 30min after last coating, in right hind foot of rat plantar aponeurosis 1% carrageenan 0.05ml of lower injection cause it is scorching, measured using rat foot claw volume measuring apparatus cause it is scorching before and cause it is scorching after 1,2,4,6, 8h rat's foot volume.

4, experimental result: each time point rat paw edema rate is calculated, the results are shown in Table 4.

4 embodiment of table, 6 present invention causes the inhibition assay result of rat paw edema to carrageenan

As can be seen from the above table, experimental group A~experimental group E causes rat paw edema to have inhibition well carrageenan Effect, for commercially available control group, although its inhibiting rate is higher, commercially available control group medicament Fluocet is amcinonide Cream is accordance with tolerance therapeutant, has side effect to children's use, is used for a long time and dependence facial dermatitis and local pigment easily occur The symptoms such as calmness, crinosity.And the application will not generate dependence without hormone using pure Chinese medicine component, be free from side effects.

(paraxylene of the present invention causes the increased inhibition of mouse web portion capillary permeability real to the anti-inflammatory experiment of embodiment 17 It tests)

1, medicament

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is a~e respectively；

1.2 positive controls: commercially available Fluonex.

2, animal: KM (Kunming kind) mouse is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.

3, experimental method: healthy mice 70 for selecting 18-22g of weight, all-male is randomly divided into 7 groups by weight, specifically It is divided into blank control group, experimental group a~experimental group e, positive controls.It is administered by table 5, is applied on every group of mouse web portion skin of unhairing It applies medicinal lotion or ointment liquid, each 0.4ml/ is only, 2 times a day, each 1 time of upper and lower noon, continuous 4 days, quiet through mouse tail after the last administration after 30min Arteries and veins injects 0.5% Evans blue normal saline solution 0.1ml/10gB.W., immediately on the position of mouse web portion skin of unhairing center Melted paraxylene 0.03ml/ only, carries out reagent processing after 20min, measure A value (absorbance) after 3 days.

4, experimental result: test A value and inhibiting rate the results are shown in Table 5.

The paraxylene of the present invention of table 5 causes the increased inhibition assay result of mouse web portion capillary permeability

Grouping	Number of animals (only)	Medicament	A value	Inhibiting rate (%)
					Blank control group	10	Distilled water	0.66±0.18	—
Experimental group a	10	Embodiment 1	0.27±0.09	59.09
					Experimental group b	10	Embodiment 2	0.27±0.08	60.06
Experimental group c	10	Embodiment 3	0.39±0.09	40.90
					Experimental group d	10	Embodiment 4	0.33±0.11	50.00
Experimental group e	10	Embodiment 5	0.29±0.08	56.06
					Positive controls	10	Fluocet	0.15±0.03	77.27

As can be seen from the above table, experimental group a~experimental group e paraxylene causes mouse web portion capillary permeability to increase tool There is good inhibitory effect, for commercially available control group, although its inhibiting rate is higher, commercially available control group medicament Fluocet It is accordance with tolerance therapeutant for hormone ointment, side effect is had to children's use, easily there is dependence facial dermatitis in long-time service, with And the symptoms such as local pigment calmness, crinosity.And the application will not generate dependence without hormone using pure Chinese medicine component, without pair Effect.

The anti-inflammatory experiment of embodiment 18 (present invention causes the increased Inhibition test of mouse skin capillary permeability to histamine)

1, medicament:

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is I~V respectively；

1.2 positive controls: commercially available cyproheptadine hydrochloride cream.

2, animal: SD rat is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.

3, experimental method: healthy SD rat 70 for selecting 180-220g of weight, all-male is randomly divided into 7 groups by weight, It is specifically divided into blank control group, group I~experimental group V, positive controls.It is administered by table 6, every group of rat carries on the back in its unhairing Medical fluid is embrocated in portion, each 0.4ml/ only, 2 times a day, the upper and lower noon each 1 time, continuous 4 days.30min after the last administration, tail vein note 1% Evans blue normal saline solution 0.4ml/10gB.W. is penetrated, hits exactly 0.1% phosphorus of position intracutaneous injection in back coating immediately Sour histamine 0.1ml/ only, carries out reagent processing after 30min, measure A value (absorbance) after 3 days.

4, experimental result: test A value and inhibiting rate the results are shown in Table 6.

6 present invention of table causes the increased inhibition assay result of mouse skin capillary permeability to histamine

Grouping	Number of animals (only)	Medicament	A value	Inhibiting rate (%)
					Blank control group	10	Distilled water	0.48±0.11	—
Group I	10	Embodiment 1	0.20±0.08	43.33
					Experimental group II	10	Embodiment 2	0.36±0.17	55.06
Experimental group III	10	Embodiment 3	0.23±0.10	52.08
					Experimental group IV	10	Embodiment 4	0.28±0.11	41.67
Experimental group V	10	Embodiment 5	0.22±0.08	54.17
					Positive controls	10	Cyproheptadine hydrochloride cream	0.14±0.03	70.83

As can be seen from the above table, group I~experimental group V causes mouse skin capillary permeability to increase tool in histamine There is good inhibitory effect, for commercially available control group, although its inhibiting rate is higher, commercially available control group medicament anarexol Emulsifiable paste is hormone ointment, is accordance with tolerance therapeutant, has side effect to children's use, is used for a long time and dependence skin easily occur The symptoms such as inflammation and local pigment calmness, crinosity.And the application will not generate dependence without hormone using pure Chinese medicine component, It is free from side effects.

Embodiment 19 it is antipruritic experiment (present invention to histamine phosphate cause itch reaction influence test)

1, medicament:

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is I~5 respectively；

1.2 positive controls: commercially available cyproheptadine hydrochloride cream.

2, animal: cavy (Britain's kind) is provided by farm of experimental animal special commission of Sichuan Province.

3, experimental method: healthy guinea pig 70 for selecting 250-300g of weight, half male and half female is randomly divided into 7 by weight Group is specifically divided into blank control group, 1~experimental group of experimental group 5, positive controls.It is administered by table 7, before experiment, every group of cavy is right Instep shaving afterwards, area 1cm², embrocate daily medical fluid 2 times, the upper and lower noon is each primary, and continuous 4 days, experiment was wiped when daily coarse sandpaper It after wound is right at the shaving of instep, is allowed to rubescent, but is degree with not bleeding, coating twice, is spaced 1 hour again for part, after last coating 10min starts to apply 0.01% histamine phosphate, 50 μ L/ only in the surface of a wound, and later every 3min is passed according to 0.02%, 0.03%, 0.04% Enrichment degree is 50 μ L/ every time, until cavy occur turns one's head the total amount for giving histamine phosphate when licking right metapedes to cause to itch Threshold.It the results are shown in Table 7.

The present invention of table 7 causes to itch the influence experimental result of reaction to histamine phosphate

Grouping	Number of animals (only)	Medicament	Itch-threshold (μ g)
				Blank control group	10	Distilled water	0.13±0.09
Experimental group 1	10	Embodiment 1	0.46±0.18
				Experimental group 2	10	Embodiment 2	0.51±0.43
Experimental group 3	10	Embodiment 3	0.48±0.30
				Experimental group 4	10	Embodiment 4	0.50±0.28
Experimental group 5	10	Embodiment 5	0.45±0.09
				Positive controls	10	Cyproheptadine hydrochloride cream	0.71±0.40

As can be seen from the above table, 1~experimental group of experimental group 5 causes to itch in reaction to histamine phosphate, and itch-threshold is higher, For commercially available control group, although its itch-threshold is higher, commercially available control group medicament cyproheptadine hydrochloride cream is hormone ointment, It is accordance with tolerance therapeutant, side effect is had to children's use, dependence facial dermatitis easily occurs in long-time service and local pigment is heavy , the symptoms such as crinosity.And the application will not generate dependence without hormone using pure Chinese medicine component, be free from side effects.

The experiment of 20 skin allergy of embodiment

1, medicament:

1.1 experimental groups: composition gels described in embodiment 1 to embodiment 5, number is I~5 respectively；

1.2 positive controls: 2,4- dinitro-chloro-benzene.

2, animal: cavy (white Britain's kind) is provided by farm of experimental animal special commission of Sichuan Province.

3, experimental method: healthy guinea pig 70 for selecting 250-300g of weight, half male and half female is randomly divided into 7 by weight Group is specifically divided into positive controls (giving 2,4- dinitro-chloro-benzene), 1~experimental group of experimental group 5 (gives embodiment 1 to reality Apply preparation described in example 5), blank control group (giving distilled water).Proxima luce (prox. luc) is tested, by skin shaving (area on the right side of guinea pig back For 3cm²), the same day is tested, in right side shaving area daubing medicament 0.2mL, is then covered with one layer of oilpaper and two layers of gauze, then with Non-stimulated immobilization with adhesive tape, continues to wash away for 6 hours drug, and in hereafter 24,48,72 hours observation cutaneous anaphylaxises situations such as.

4, sensitization rate is calculated, experimental result is shown in Table 8.

8 embodiment of table, 8 skin allergy experimental result

Grouping	Number of animals (only)	Medicament	Sensitization rate (%)
				Blank control group	10	Distilled water	0
Experimental group 1	10	Embodiment 1	0
				Experimental group 2	10	Embodiment 2	0
Experimental group 3	10	Embodiment 3	0
				Experimental group 4	10	Embodiment 4	0
Experimental group 5	10	Embodiment 5	0
				Positive controls	10	2,4- dinitro-chloro-benzene	100

More than 21 skin irritation tests of embodiment

1, medicament: composition gels described in embodiment 1 to embodiment 5, number is I~5 respectively.

2, animal: rabbit, Japan large ear rabbit, half male and half female are provided by farm of experimental animal special commission of Sichuan Province.

3, experimental method: healthy rabbits 15 are selected, 5 groups is randomly divided into, is specifically divided into experimental group (1-5), using itself Left and right sides control.With 8% vulcanized sodium be in rabbit back depilation, each 3cm × 3cm of unhairing range arranged on left and right sides.It checks and goes before administration Whether fur skin injured due to unhairing, and injured skin should not be tested, next day in back hair removal section daubing medicament, wherein left Side skin is compared with distilled water, and preparation described in embodiment 1 to embodiment 5 is given on right side, once a day, continuous 14 days, and every time 4h after smearing washes away residue with warm water, and the feelings of erythema and oedema occurs in 1,24,48,72 hour skin of back after observation is discontinued Condition.

4, experimental result is shown in Table 7.

7 embodiment of table, 9 skin irritation test result

Note: "None" occurs for no erythema oedema.

The medicine composite for curing example provided by the invention of embodiment 22

Case 1:

Name: Zhao, gender: male, the age: 31 years old, consultation time on 07 26th, 2014, occupation: Kuai Xiao product enterprise pin Vender's pipe, area: Chongqing, symptom: being applied with DOMS plaster, and there is an intensive papule at back, local skin flush, with swelling, Skin Lightening, surface texture disappear, and examine as contact dermatitis, the pharmaceutical composition gel provided using the embodiment of the present invention 1,1 Day 3 times, it is uniformly applied to dermatitis happening part, symptom mitigates after 1 day, and swelling obviously subsides, fully recovers after 3 days, only remaining skin lesion trace Mark.

Case 2:

Name: Zhang, gender: female, the age: 28 years old, consultation time on 07 11st, 2015, occupation: mall shopping, ground Area: Guizhou Kweiyang, symptom: be applied with use bruise plaster, rear waist plaster viscose locally occur the more clear color of the leather flush of boundary, Swelling, surrounding have the papule being dispersed in, the pharmaceutical composition gel provided using the embodiment of the present invention 2, three times a day, symptom after 1 day Mitigate, fully recovers within 2nd, no skin lesion trace.

Case 3:

Name: it is remaining certain, gender: male, the age: 40 years old, consultation time on 06 08th, 2015, occupation: decoration worker, ground Area: Sichuan Meishan, symptom: having paint contact history before the onset, and local swelling, flush are shown in have intensive papule, part to burn Heat is examined as contact dermatitis.The pharmaceutical composition gel provided using the embodiment of the present invention 3, three times a day, same day symptom are mitigated, It fully recovers after a week, no skin lesion trace.

Case 4:

Name: Liu, gender: male, the age: 19 years old, consultation time on 01 17th, 2016, occupation: certain colleges and universities big one were learned Raw, area: Sichuan Chengdu: locally there is the more clear color of the leather flush of boundary using viscose after adhesive bandage in symptom, and part is scorching hot, Itch is examined as contact dermatitis.The pharmaceutical composition gel provided using the embodiment of the present invention 4, three times a day, same day symptom subtracts Gently, it fully recovers after 2 days, no skin lesion trace.

Case 5

Name: reviving certain, gender: female, the age: 22 years old, consultation time on December 17th, 2015, and occupation: public institution civilian, Area: Sichuan Chengdu, symptom: having skin allergy history, belongs to sensitive skin, is occurred using skin of dorsum of hand after new purchase leather glove Color of the leather flush, scorching hot, the itch in part, is examined as contact dermatitis.The pharmaceutical composition gel provided using the embodiment of the present invention 5,1 Symptom mitigates after days 3 times, 1 day, fully recovers after 3 days, no skin lesion trace.

Case 6

Name: reviving certain, gender: female, the age: 2 years old half, consultation time on May 10th, 2016, and area: zhuzhou,hunan, disease Shape: there are multiple subfusiform wheals in trunk, both legs, and there are small papule, violent itch in individual wheal centers, and children's scratching does not stop, It examines as insect bite dermatitis, the pharmaceutical composition gel provided using the embodiment of the present invention 1, after wheal is 5 to 6 times on the 1st, 2 days local Symptom mitigates, and fully recovers after a week, there is deeper skin lesion trace.Skin lesion trace disappears after follow-up 3 months.

Case 7

Name: field, gender: female, the age: 10 years old, consultation time on June 10th, 2015, area: Sichuan Deyang, symptom: Occur linear or streak redness on the outside of arm, above there is intensive papule, conscious scorching hot, pain is examined as (rove beetle) insect bite Property dermatitis, the pharmaceutical composition gel provided using the embodiment of the present invention 2, local use 5 to 6 times on the 1st, same day symptom mitigate, It fully recovers after a week, there is deeper skin lesion trace.

Case 8

Name: Liu, gender: male, the age: 31 years old, consultation time on June 15th, 2016, area: Sichuan Chengdu, symptom: There are multiple subfusiform wheals in the regions such as left hand back, shoulder, waist, there is swelling, with violent itch, examine as insect bite dermatitis, The pharmaceutical composition gel provided using the embodiment of the present invention 3, local use 5 to 6 times on the 1st, symptom mitigated on 2nd, reduced after 4 days It for middle finger size erythema, fully recovers after a week, there is deeper skin lesion trace.

Case 9

Name: Mr. Wang, gender: male, the age: 27 years old, consultation time on August 01st, 2015, area: Chongqing, symptom: shank There are multiple soya bean size papules in tripe region, with violent itch, examines as insect bite dermatitis, is provided using the embodiment of the present invention 4 Pharmaceutical composition gel, local use 5 to 6 times on the 1st, symptom mitigated at that time, and same day recovery from illness, there are minimum red papules sample skins Damage, follow-up papule sample disappear after skin lesion 5 days.

Case 10

Name: Zhao, gender: female, the age: 23 years old, consultation time on 06 28th, 2016, area: Sichuan Suining, disease Shape: it is double-legged, occur more intensive subfusiform at ankle, red papules not of uniform size are examined with violent itch as insect bite skin Inflammation, the pharmaceutical composition gel provided using the embodiment of the present invention 5, local use 5 to 6 times on the 1st, symptom mitigated at that time, and one week After fully recover, there are minimum red papules sample skin lesion, follow-up papule sample skin lesion disappears after two weeks.

The above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair Limitation of the invention, protection scope of the present invention should be defined by the scope defined by the claims..For the art For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change It also should be regarded as protection scope of the present invention into retouching.

Claims (10)

1. a kind of pharmaceutical composition for dermatitis, which is characterized in that composition component score by weight is calculated as: matrine 3-20 parts, 1~10 part of Osthole, momordin Ic2~15 part, 3~20 parts of Paeonol, 8~40 parts of glycyrrhizic acid, menthol 10~48 parts, 5~30 parts of bisabolol.

2. pharmaceutical composition according to claim 1, which is characterized in that component score by weight is calculated as: matrine 5 ~15 parts, 1~6 part of Osthole, momordin Ic2~10 part, 5-15 parts of Paeonol, 15~30 parts of glycyrrhizic acid, menthol 25~45 parts, 8~25 parts of bisabolol.

3. pharmaceutical composition according to claim 1, which is characterized in that the raw material of the composition be kuh-seng, frutus cnidii, The fruit of summer cypress, cortex moutan, Radix Glycyrrhizae, menthol, bisabolol.

4. pharmaceutical composition according to claim 3, which is characterized in that the matrine is the extract of the kuh-seng, The Osthole is the extract of the frutus cnidii, and the momordin Ic is the extract of the fruit of summer cypress, the pellet The extract that skin phenol is the extract of the cortex moutan, the glycyrrhizic acid is the Radix Glycyrrhizae.

5. pharmaceutical composition according to claim 3, which is characterized in that the raw material includes: kuh-seng according to parts by weight 100~500 parts, 50~400 parts of frutus cnidii, 50~400 parts of the fruit of summer cypress, 150~1000 parts of cortex moutan, 200~2000 parts of Radix Glycyrrhizae, 10~48 parts of menthol, 5~30 parts of bisabolol.

6. application of any one composition in the drug of preparation treatment dermatitis according to claim 1~5.

7. application according to claim 6, which is characterized in that the dermatitis is insect dermatitis, contact dermatitis.

8. a kind of preparation of the pharmaceutical composition for dermatitis, which is characterized in that by the combination of any one of Claims 1 to 5 Object and pharmaceutically acceptable auxiliary material are made.

9. a kind of preparation method of the pharmaceutical composition for dermatitis, which is characterized in that in parts by weight, by matrine 5 ~15 parts, 1~6 part of Osthole, momordin Ic2~10 part, 5-15 parts of Paeonol, 15~30 parts of glycyrrhizic acid, menthol 25~45 parts, 8~25 parts of bisabolol, mix in a solvent, obtain the composition.

10. preparation method according to claim 9, which is characterized in that the solvent is ethyl alcohol.