CN103751245B - One treats dermopathic Chinese medicine composition and uses thereof - Google Patents
One treats dermopathic Chinese medicine composition and uses thereof Download PDFInfo
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Abstract
The present invention relates to one and treat dermopathic Chinese medicine composition and uses thereof, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part, and the medicament of described Chinese medicine composition can be lotion, tincture, oil preparation, Emulsion, ointment, plaster or gel.This traditional Chinese medicine composition for treating dermatosis especially eczema, neurodermatitis and skin ulcer is evident in efficacy, and cure rate is high, and this Chinese medicine composition flavour of a drug number is few simultaneously, prepare easy, cost is low, and is pass through percutaneous drug delivery, toxic and side effects is little, and safety is high, is easy to be accepted by patient.
Description
[technical field]
The present invention relates to one and treat dermopathic Chinese medicine composition and uses thereof, specifically, be a kind of take Chinese herbal medicine as Chinese patent medicine prepared by raw material.
[background technology]
Eczema is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor.Divide acute, subacute, chronic three phases.Acute stage, tool oozed out tendency, and chronic phase then infiltrates, plumpness.The skin lesion of general eczema is pleomorphism, and based on erythema, pimple, papulovesicle, erythra central authorities obviously, scatter gradually towards periphery, indefinite border, and diffusivity, has and ooze out tendency, and chronic person then has infiltration plump.
Neurodermatitis is also known as lichen chronicus simplex, it is a kind of chronic inflammation disease being feature with skin lichenification and violent pruritus, it is generally acknowledged the generation of primary disease may be cerebral cortex suppress and excited dysfunction caused by, psychentonia, anxiety, depression, local excitation (as rubbed, expecting day, hyperhidrosis) and dyspepsia, drink, take food and pungent etc. all can bring out or increase the weight of primary disease.
Skin ulcer is surgery of Chinese medicine commonly encountered diseases, frequently-occurring disease, is be that main clinical manifestation can not heal for a long time for Clinical symptoms with skin ulcer, a kind of body surface disease of Skin preparation liquefaction infection and necrosis, make a general reference herein surgery of Chinese medicine skin infection class burst after long-term more person.Be difficult to healing due to skin ulcer face and consume very large, causing very large mental pressure and economic loss to patient, have a strong impact on the healthy of patient and quality of life.
Be used for the treatment of above dermopathic Chinese medicine kind at present more, as Chinese patent literature CN201310358800.6, publication date 2013.11.13, disclose a kind of compound Chinese medicine external preparation for the treatment of dermatitis and eczema class disease, it is characterized in that being prepared from by the raw material of following weight percents and pharmaceutically acceptable carrier: Adeps Serpentis 3-15 part, Radix Arnebiae (Radix Lithospermi) 3-12 part, Ilex purpurea Hassk.[I.chinensis Sims 10-45 part.Its dosage form is ointment, Emulsion, liniment, liposome or spray.This invention is applied to the clinical treatment of dermatitis and eczema class disease, has the effects such as antiinflammatory, antiallergic, antibacterial, moisturizing, and Be very effective.Chinese patent literature CN201110338788.3, publication date 2013.05.08, disclose a kind of Chinese medicine preparation for the treatment of skin ulcer, this Chinese medicine preparation is prepared from by the crude drug of following weight portion: Rhizoma Coptidis 0.5-2 part, Cortex Phellodendri 0.5-2 part, Radix Pulsatillae 1-3 part, Herba Portulacae 1-3 part, Matrii Sulfas Exsiccatus 2-4 part, Cortex Pseudolaricis 1-3 part, Flos Carthami 0.5-2 part.This Chinese medicine preparation can be made into tablet, mixture, granule and capsule, external has effect of clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain, cure mainly various skin ulcer, be particularly useful for treating the skin wounds such as varicose ulcer of lower extremity, traumatic ulcer, infective ulcer with the red and swollen disease of oozing out for cardinal symptom in local.And research and development more extensively can treat all kinds of dermatosis, component is few, cost is low Chinese medicine composition remains very necessary.
[summary of the invention]
The object of the invention is for deficiency of the prior art, provide one to treat dermopathic Chinese medicine composition.
Of the present invention again one object be that the preparation method of above-mentioned Chinese medicine composition is provided.
Another object of the present invention provides the purposes of above-mentioned Chinese medicine composition.
For achieving the above object, the technical scheme that the present invention takes is:
One treats dermopathic Chinese medicine composition, and it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part.
Preferably, described Chinese medicine composition is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 25-35 part, Herba Erodii 45-55 part, Herba Saxifragae 45-55 part.
More preferably, described Chinese medicine composition is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 30 parts, Herba Erodii 50 parts, Herba Saxifragae 50 parts.
The medicament of described Chinese medicine composition is lotion, tincture, oil preparation, Emulsion, ointment, plaster or gel.
Preferably, the medicament of described Chinese medicine composition is oil preparation.
Preferably, be olive oil as the vegetable oil of adjuvant in described oil preparation.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
A kind of preparation method of Chinese medicine composition as above, comprise the following steps: take Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part by weight, add 600-1200 part olive oil, soak 24-72 hour, then low baking temperature decocts to crude drug burned black, crosses leaching oil after natural cooling.
For realizing above-mentioned 3rd object, the technical scheme that the present invention takes is:
As above the purposes of arbitrary described Chinese medicine composition in preparation treatment dermatosis treating medicine.
Described dermatosis is eczema, neurodermatitis or skin ulcer.
The invention has the advantages that:
1, especially eczema, neurodermatitis and skin ulcer are evident in efficacy to treat dermatosis, and cure rate is high;
2, flavour of a drug number is few, only three taste medicines, and preparation is simple, and cost is low;
3, by percutaneous drug delivery, toxic and side effects is little, and safety is high, is easy to be accepted by patient.
[detailed description of the invention]
Below detailed description of the invention provided by the invention is elaborated.
Embodiment 1 Chinese medicine composition preparation () of the present invention
Take Folium Artemisiae Argyi 30 parts, Herba Erodii 50 parts, Herba Saxifragae 50 parts by weight, add 900 parts of olive oil, soak 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 2 Chinese medicine composition preparation (two) of the present invention
Take Folium Artemisiae Argyi 20 parts, Herba Erodii 60 parts, Herba Saxifragae 40 parts by weight, add 1200 parts of olive oil, soak 24 hours, then low baking temperature decocts about 8 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 3 Chinese medicine composition preparation (three) of the present invention
Take Folium Artemisiae Argyi 40 parts, Herba Erodii 40 parts, Herba Saxifragae 60 parts by weight, add 600 parts of olive oil, soak 72 hours, then low baking temperature decocts about 6 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 4 Chinese medicine composition preparation (four) of the present invention
Take Folium Artemisiae Argyi 20 parts, Herba Erodii 40 parts, Herba Saxifragae 60 parts by weight, add 1200 parts of olive oil, soak 72 hours, then low baking temperature decocts about 6 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 5 Chinese medicine composition preparation (five) of the present invention
Take Folium Artemisiae Argyi 25 parts, Herba Erodii 55 parts, Herba Saxifragae 45 parts by weight, add 600 parts of olive oil, soak 72 hours, then low baking temperature decocts about 8 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 6 Chinese medicine composition preparation (six) of the present invention
Take Folium Artemisiae Argyi 35 parts, Herba Erodii 45 parts, Herba Saxifragae 55 parts by weight, add 800 parts of olive oil, soak 60 hours, then low baking temperature decocts about 6 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 7 Chinese medicine composition preparation (seven) of the present invention
Take Folium Artemisiae Argyi 40 parts, Herba Erodii 60 parts, Herba Saxifragae 60 parts by weight, add 1000 parts of olive oil, soak 36 hours, then low baking temperature decocts about 8 little burned black up to crude drug, crosses leaching oil after natural cooling.
Embodiment 8 Chinese medicine composition preparation (eight) of the present invention
Take Folium Artemisiae Argyi 40 parts, Herba Erodii 40 parts, Herba Saxifragae 60 parts by weight, add 1000 parts of olive oil, soak 36 hours, then low baking temperature decocts about 6 little burned black up to crude drug, crosses leaching oil after natural cooling.
The preparation of embodiment 9 Chinese medicine composition lotion of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, add 8-12 times of water gaging, decoct 3-4 hour, leach medicine juice, then add 5-6 times of water gaging, decoct 2-3 hour, leach medicine juice, merge secondary decocting liquid.
The preparation of embodiment 10 Chinese medicine composite tincture of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, add 8-12 times of water gaging, decoct 3-4 hour, leach medicine juice, then add 5-6 times of water gaging, decoct 2-3 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount ethanol, stir precipitates overnight.Get supernatant, be concentrated into thick extractum, adding normal concentration is 60% appropriate amount of ethanol, dissolves or dilution, leaves standstill, to obtain final product.
The preparation of embodiment 11 Chinese medicine composition Emulsion of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, add 8-12 times of water gaging, decoct 3-4 hour, leach medicine juice, then add 5-6 times of water gaging, decoct 2-3 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add concentrated solution 2.5 times amount ethanol, stir precipitates overnight.Get supernatant, be concentrated into thick extractum.Get soybean oil, add gummi arabicum pulveratum grinding evenly, in oil: water: glue is that the ratio of 4:2:1 adds distilled water, is ground to colostrum.Thick extractum is mixed with colostrum, stirs.
The preparation of embodiment 12 Chinese medicine composition ointment of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, add 8-12 times of water gaging, decoct 3-4 hour, leach medicine juice, add 5-6 times of water gaging again, decoct 2-3 hour, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, adds Cera Flava and Yellow Vaselin is appropriate, slow fire (about 100 DEG C) decocts 15-30min again, is cooled to paste and get final product.
The preparation of embodiment 13 Chinese medicine composition plaster of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, smash.Put in pot by vegetable oil (as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods), dropped into by above-mentioned spice after slight fever, heating is also constantly stirred, until it is degree that spice explodes inner sallow to surperficial dark brown.Explode well and drag for medicinal residues with iron wire, the oil after removing slag is medicine oil.Oil of getting it filled continues to temper to dripping into pearl.After being smelt, from Huo Xiadan, general 500g oil adds 250g pellet, and Plumbum preparatium is first dry and cross 100 mesh sieves before lower, and add pellet on a small quantity, limit edged stirs until stir into the mastic of thickness.After spraying goes " fire-toxin ", get a certain amount of plaster on kraft paper or plaster cloth with bamboo let, Moschus and volatile Borneolum Syntheticum, Camphora, Herba Menthae etc. can finally sprinkle.
The preparation of embodiment 14 Chinese medicine composition gelata of the present invention
Take Folium Artemisiae Argyi, Herba Erodii, Herba Saxifragae by the arbitrary described weight portion of claim 1-8, smash.Put in pot by a small amount of vegetable oil (as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods), dropped into by above-mentioned spice after slight fever, heating decocts and constantly stirs, and gets filtrate.Carbomer being added grinding in glycerol makes moistening, then after adding the grinding of a small amount of distilled water, moves on in measuring cup, separately get triethanolamine, oxybenzene second fat, distilled water make dissolving in right amount, stir into gel, then add appropriate distilled water and stir evenly, add above-mentioned medical material filtrate, grind well and get final product.
The clinical trial of embodiment 15 traditional Chinese medicine composition for treating eczema of the present invention
1, case is selected
Select patient 120 example from Dermatology Outpatient Department, all patients all meet the diagnostic criteria of eczema and meet the symmetric feature of main skin lesion.Wherein male be 52 example, women be 68 example, age reckling 18 years old, the maximum 60 years old, the mean age be (38.02 ± 16.37) year.The shortest person of the course of disease is 1 week, and the most elder of the course of disease is 3 years, and average course of disease is (9.25 ± 13.08) individual month.The skin lesion distribution situation of object of study: Head And Face, upper limb, trunk, lower limb proportion are respectively 23.58%, 50.39%, 45.61%, 41.71%.
2, Therapeutic Method
(1) treatment group: use warm water cleaning affected part, wipes the Chinese medicine composition oil preparation got after doing and adopt embodiment 1 to prepare, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm
2the dosed administration of skin lesion, sooner or later respectively once, 14 days courses for the treatment of, patient's further consultation in the 14th day after treatment, treatments period is without endo-medicine.
(2) matched group one: take Folium Artemisiae Argyi 55 parts, Herba Erodii 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil after natural cooling, must this group treatment Chinese medicine oil preparation.Medication and the course for the treatment of same treatment group.
(3) matched group two: take Folium Artemisiae Argyi 55 parts, Herba Saxifragae 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil after natural cooling, must this group treatment Chinese medicine oil preparation.Medication and the course for the treatment of same treatment group.
(4) matched group three: take Herba Erodii 65 parts, Herba Saxifragae 65 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil after natural cooling, must this group treatment Chinese medicine oil preparation.Medication and the course for the treatment of same treatment group.
3, observation of curative effect and deliberated index
During further consultation, eczema area and severity index (EASI) scoring are carried out to patient respectively at before treatment and after treatment.
3.1 eczema area and Severity Index (EASI)
According to table 1 and table 2, respectively the skin lesion area of patient's incidence, trunk, upper limb, lower limb and the skin being grievously injured degree are marked, calculate the EASI value of each several part, finally obtain total EASI value for the treatment of group, matched group one-matched group three according to total EASI score value=A+B+C+D.
Table 1EASI grade form (more than 8 years old)
Note: E is erythema, and I is edema or pimple, and Ex is exfoliation, and L is lichenification.
Table 2EASI score by rules
3.2 general curative effect evaluations
Curative effect index is changing value and the treatment front and back EASI scoring improvement rate of EASI scoring before and after treating.The changing value that before and after each group for the treatment of, EASI marks and improvement rate are defined as: EASI scoring before EASI scoring changing value=treatment-treat rear EASI to mark; Before EASI scoring improvement rate=(treating the rear EASI scoring of front EASI scoring-treatment)/treatment, EASI marks × 100%.
According to the clinical improvements degree before and after treatment, calculate curative effect index, curative effect overall evaluation at the end for the treatment of by recovery from illness, effective, progressive, invalid 4 grade standards.Recovery from illness EASI scoring improvement rate >90%, pruritus disappears.Effective EASI scoring improvement rate 60%-89%, pruritus obviously alleviates.Progressive EASI scoring improvement rate 20%-59%, pruritus pruritus alleviates.Invalid EASI scoring improvement rate <20%, pruritus is front or aggravation with treatment.Recovery from illness case and effective case are added up to effective case, calculates effective percentage.
4, statistical method
Adopt SPSS18.0 statistics software to carry out statistical procedures, measurement data represents with mean ± standard deviation (mean ± sd), and adopt t inspection, enumeration data adopts χ
2inspection.
5, therapeutic outcome
4.1 respectively group treatment front and back EASI value changes
Before and after each group for the treatment of, EASI value situation of change is in table 3.Before treatment, the average EASI value no difference of science of statistics (P > 0.05) for the treatment of group and matched group, has comparability.Treat after 14 days, the average EASI value of each group all has decline before comparatively treating, and mark after the treatment for the treatment of group compared with treating with arbitrary group of matched group one-matched group three and marking afterwards, difference has statistical significance (P<0.05).
Table 3 respectively group EASI scoring compares
After 4.2 each group treatments, curative effect and effective percentage compare
After each group for the treatment of, curative effect and effective percentage the results are shown in Table 4.Treat after 14 days, treatment group effective percentage is compared with arbitrary group of matched group one-matched group three, difference has statistical significance (P<0.05), effective percentage no difference of science of statistics (P > 0.05) between matched group one-matched group three.
The table 4 respectively rear curative effect of group treatment and effective percentage compares
The clinical trial of embodiment 16 traditional Chinese medicine composition for treating neurodermatitis of the present invention
1, physical data
In the routine patient of clinical collection 120, age 18-70 year, 36 years old mean age, the course of disease at 3 months to 8 years, average 4.3 years.
2, diagnostic criteria
" Chinese medical disease Standardization of diagnosis and curative effect " that diagnosis basis State Administration of Traditional Chinese Medicine issues:
(1) occur in the positions such as neck side, waist sacrum, ancon, have remarkable pruritus;
(2) erythra merges in flakes, and pachyderma is coarse, and sulci of skin is deepened, and cutaneous ridge swells, and has lichen sample and pigmentation;
(3) the chronic process of the course of disease, oozes out tendency.
3, exclusion standard
Chronic eczema, primary cutaneous amyloidosis, atopic dermatitis, lichen planus, cancer are itched disease, treat within first 1 week, stopped using antihistaminic and sugar and matter hormone, except other organs disease, anemia of pregnant woman and age of sucking patient.
4, Therapeutic Method
(1) treatment group: use warm water cleaning affected part, gently wipes Chinese medicine composition oil preparation prepared by dry rear Example 1, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm
2the dosed administration of skin lesion, sooner or later each 10 days is once a course for the treatment of, and treat further consultation after 6 courses for the treatment of, treatments period is without endo-medicine.
(2) matched group one: take Folium Artemisiae Argyi 55 parts, Herba Erodii 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil, obtain treatment Chinese medicine oil preparation after natural cooling.Medication and the course for the treatment of same treatment group.
(3) matched group two: take Folium Artemisiae Argyi 55 parts, Herba Saxifragae 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil, obtain treatment Chinese medicine oil preparation after natural cooling.Medication and the course for the treatment of same treatment group.
(4) matched group three: take Herba Erodii 65 parts, Herba Saxifragae 65 parts by weight, add 900 parts of olive oil, soaks 48 hours, and then low baking temperature decocts about 7 little burned black up to crude drug, crosses leaching oil, obtain treatment Chinese medicine oil preparation after natural cooling.Medication and the course for the treatment of same treatment group.
5, standards of grading
The scoring of 0-3 grade standard is adopted to mark to itch degree, tongue fresh sample parameter order and size (minimum diameter), plump degree, pigmentation of patient's pain before treatment and after treatment.0 is divided into without gargalesthesia, skin smooth, the pigment colour of skin; 1 is divided into idol to have pruritus, not irritated, skin lesion diameter < 0.5cm, skin lesion 1-6, and the fresh sample of slight tongue becomes, and pigment is light red; 2 are divided into moderate pruritus, but can tolerate, skin lesion diameter 1.5-2.5cm, skin lesion 7-12, and the fresh sample of moderate tongue becomes, and pigment is brown; 3 are divided into serious pruritus, are impatient at, skin lesion diameter > 2.5cm, skin lesion > 12, and pachyderma is coarse, and in tongue, liquor-saturated sample becomes and dark brown.Above-mentioned 5 marks add up to total mark.Integration decline index=[before (before treatment the rear total mark of total mark-treatment)/treatment total mark] × 100%.
Formulate with reference to " Chinese medical disease Standardization of diagnosis and curative effect ": cure, integration decline index >=90%; Effective, integration decline index is 60%-89%; Effectively, integration decline index is 20%-59%; Invalid, integration decline index≤90%.Case, effective case and effective case will be cured add up to, calculate effective percentage.
6, therapeutic outcome
After each group for the treatment of, curative effect and effective percentage the results are shown in Table 5.After treating 6 courses for the treatment of, compared with treatment group effective percentage and matched group one-matched group three arbitrary groups of effective percentage, difference has statistical significance (P<0.05).
The table 5 respectively rear curative effect of group treatment and effective percentage compares
The clinical trial of embodiment 17 traditional Chinese medicine composition for treating skin ulcer of the present invention
1, physical data
Inclusion criteria: allly meet the person that belongs to damp-heat syndrome in the non-healing person of skin ulcer more than 1 month and TCM syndrome diagnostic criteria.Age the patient in 18-75 year, male or female.
2, diagnostic criteria
(1) Western medicine diagnose standard: the non-healing person of skin ulcer more than 1 month.
(2) TCM syndrome diagnostic criteria: belong to damp-heat syndrome person, with reference to " National Standard of the People's Republic of China's tcm clinical practice diagnosis and treatment term syndrome ", " People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect " and national state-compiled textbook " Surgery of Chinese Medicine " (New Century higher institutions of Chinese medicine teaching material).
Primary symptom: wound surface is rotten dark, and pus is contaminated, and dirty smelly unpleasant, surrounding redness is scorching hot, does during pain of itching.
Secondary disease: fever with aversion to cold, thirsty, constipation, urinate red; Red tongue or greasy fur, slippery and rapid pulse.
Possesses the above-mentioned primary symptom of damp-heat syndrome two and secondary disease two can make diagnosis.
3, inclusive criteria
Meet primary disease Western medicine diagnose standard and TCM syndrome diagnostic criteria; Skin ulcer wound surface area>=2cm
2; Age>=18 one full year of life and≤75 one full year of life, men and women does not limit, informed consent, signature Informed Consent Form, and tested voluntarily.
4, standard is discharged
Do not meet diagnostic criteria and inclusive criteria person; Though or meet diagnostic criteria and inclusive criteria, have the one of following situations: be associated with the severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system, psychotic, tumor or HIV sufferers; Gestation or women breast-feeding their children, allergic constitution person; Severe infection, state of an illness danger severe one; Complication with diabetes, glycemic control instability person; Merge neural malnutrition person; Arterial disease ulcer, cancer ulcer or tuberculous ulcer, radiation ulcer, decubital ulcer, leprous ulcer, syphilelcosis; Ulcer is also shown in tendon, skeleton resurrectionist; Meet inclusive criteria, but not by regulation medication, cannot curative effect be judged, or the infull person of data.
5, Therapeutic Method
(1) treatment group: adopt Chinese medicine composition oil preparation prepared by embodiment 1, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(2) matched group one: take Folium Artemisiae Argyi 130 parts by weight, adds 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(2) matched group two: take Herba Erodii 130 parts by weight, adds 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(4) matched group three: take Herba Saxifragae 130 parts by weight, adds 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(5) matched group four: take Folium Artemisiae Argyi 55 parts, Herba Erodii 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(6) matched group five: take Folium Artemisiae Argyi 55 parts, Herba Saxifragae 75 parts by weight, add 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
(7) matched group six: take Herba Erodii 65 parts, Herba Saxifragae 65 parts by weight, add 900 parts of olive oil, soaks 48 hours, then low baking temperature decocts about 7 little burned black up to crude drug, leaching oil is crossed, with cotton swab uniform application skin lesion affected part, according to about 2g crude drug crude drug/cm after natural cooling
2the dosed administration of skin lesion, sooner or later respectively once, treating 4 weeks was 1 course for the treatment of, and sentence effect after 3 courses for the treatment of, treatments period is without endo-medicine.
6, index of assessment of curative effect
Judge with reference to " Chinese medical disease Standardization of diagnosis and curative effect ", " Shanghai City Chinese medical disease conventional treatment " (the 2nd edition): clinical recovery: more than improvement rate >=95%; Effective: 70%≤improvement rate < 95%; Effective: 30%≤improvement rate < 70%; Invalid: improvement rate < 30%.Total effective rate=cure rate+obvious effective rate+effective percentage.
7, therapeutic outcome
The total effective rate statistical result of each group is in table 6, result shows that treatment group total effective rate is significantly higher than arbitrary group of matched group one-matched group six (P<0.05), wherein reach pole significant level (P<0.01) with the difference of matched group one-matched group three, between matched group four-matched group five, comparing difference is not significantly (P>0.05), also can find out, the healing speed for the treatment of group is fast, fully recover after treat 3 courses for the treatment of and effective number many.
Table 6 is the statistical result of group total effective rate respectively
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (8)
1. treat a Chinese medicine composition for eczema, neurodermatitis or skin ulcer, it is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part.
2. Chinese medicine composition according to claim 1, is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 25-35 part, Herba Erodii 45-55 part, Herba Saxifragae 45-55 part.
3. Chinese medicine composition according to claim 2, is characterized in that, it is made up of the crude drug of following weight portion: Folium Artemisiae Argyi 30 parts, Herba Erodii 50 parts, Herba Saxifragae 50 parts.
4. Chinese medicine composition according to claim 1, is characterized in that, the medicament of described Chinese medicine composition is lotion, tincture, oil preparation, Emulsion, ointment, plaster or gel.
5. Chinese medicine composition according to claim 4, is characterized in that, the medicament of described Chinese medicine composition is oil preparation.
6. Chinese medicine composition according to claim 5, is characterized in that, is olive oil as the vegetable oil of adjuvant in described oil preparation.
7. the preparation method of a Chinese medicine composition according to claim 1, it is characterized in that, comprise the following steps: take Folium Artemisiae Argyi 20-40 part, Herba Erodii 40-60 part, Herba Saxifragae 40-60 part by weight, add 600-1200 part olive oil, soak 24-72 hour, then low baking temperature decocts to crude drug burned black, crosses leaching oil after natural cooling.
8. the purposes of the arbitrary described Chinese medicine composition of claim 1-6 in preparation treatment dermatosis treating medicine, described dermatosis is eczema, neurodermatitis or skin ulcer.
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| CN106511410A (en) * | 2017-01-03 | 2017-03-22 | 遵义医学院 | Herba Saxifragae ointment for treating skin diseases and preparation method of Herba Saxifragae ointment for treating skin diseases |
| CN107995867A (en) * | 2017-10-27 | 2018-05-04 | 江苏奇力康皮肤药业有限公司 | A kind of long-acting slow-release Chinese medicine cold compress patch for being used to treat skin ulcer |
| CN117530996B (en) * | 2023-12-11 | 2024-08-09 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for treating atopic dermatitis and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1876046A (en) * | 2006-04-14 | 2006-12-13 | 盛芳 | Traditional Chinese medicine for treating bedsore |
| CN101053602A (en) * | 2007-04-25 | 2007-10-17 | 昆明涞章医药科技有限公司 | Medicine for treating oral ulcer and its preparing method |
| CN102008593A (en) * | 2010-12-10 | 2011-04-13 | 西安医学院 | Animal antibacterial and anti-virus Chinese medicinal composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1876046A (en) * | 2006-04-14 | 2006-12-13 | 盛芳 | Traditional Chinese medicine for treating bedsore |
| CN101053602A (en) * | 2007-04-25 | 2007-10-17 | 昆明涞章医药科技有限公司 | Medicine for treating oral ulcer and its preparing method |
| CN102008593A (en) * | 2010-12-10 | 2011-04-13 | 西安医学院 | Animal antibacterial and anti-virus Chinese medicinal composition and preparation method thereof |
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