CN105213584A - A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of eczema and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to technical field of Chinese medicines, disclose a kind of Chinese medicine composition for the treatment of eczema and preparation method thereof.This Chinese medicine composition comprises the Chinese crude drug of following parts by weight: Folium Mori 4-24 part, Cortex Phellodendri 5-15 part, Fructus Kochiae 10-15 part, Radix Sophorae Flavescentis 4-14 part, Fructus Cnidii 2-10 part, Radix Et Rhizoma Rhei 4-10 part, Radix Scutellariae 3-6 part, Radix Gentianae 2-6 part, Rhizoma Atractylodis 2-8 part, Poria 4-10 part, Radix Paeoniae Rubra 5-9 part, Semen Plantaginis 6-12 part, Fructus Evodiae 2-6 part and Radix Glycyrrhizae 6-16 part.The present invention adopts natural Chinese medicine, and its component is simple, reasonable mixture ratio, toxic and side effects are little, easy to use, has effect of detoxifying and relieving itching, promoting diuresis to eliminate damp pathogen, can effectively treat acute and chronic eczema.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of eczema and preparation method thereof.
Background technology
Eczema (eczema) is the struvite anaphylaxis dermatosis of a kind of common epidermis caused by multiple internal and external factor and high dermis, and it is generally acknowledged has certain relation with allergy.Divide acute, subacute, chronic three phases.Acute stage, tool oozed out tendency, and chronic phase then infiltrates, plumpness.Some patient directly translates into chronic eczema.Skin lesion has the features such as pleomorphism, symmetry, pruritus and easy recurrent exerbation.Ancients are referred to as " acute eczema ", " eczema of ear ", " eczema of scrotum ", " infantile eczema " etc., its symptom is eczema performance.Any age, any position, any season can be betided, but be everlasting recurrence in winter or aggravation.Primary disease as treated not in time and thoroughly, then can cause secondary infection, skin injury, desquamation etc., even can cause malnutrition, degradation under resistance.
Eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill is as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes, endocrine disturbance, infection, dysbolism etc., and exopathogenic factor such as living environment, climate change, food etc. all can affect the generation of eczema.Environmental stimuli as daylight, cold, drying, sweltering heat, hot water is scalded and various animal skin, plant, cosmetics, soap, staple fibre etc. all can bring out.Eczema is a kind of delayed allergy that the complicated inside and outside factor causes.
In doctor trained in Western medicine, eczema is the very complicated disease relevant with immunity of a kind of cause of disease, still can not effect a radical cure at present, can only control with medicine.This sick Chinese traditional treatment effect is better, and the traditional Chinese medical science thinks that this disease is main relevant with damp, wet can intrinsic heat, sending out is damp and hot card, the of a specified duration then impairment of the spleen that wets, heat then impairment of YIN blood, and the card causing simulataneous insufficiency and excessive.The common damp and hot card of acute eczema, chronic eczema mostly is the card of simulataneous insufficiency and excessive.Because damp exists, therefore recurrent exerbation.
The method of existing treatment eczema is divided into Topical therapy and interior therapy two kinds, and interior therapy selects antihistaminic antipruritic, and two kinds coordinate or are used alternatingly if desired.Universal eczema can oral or injection glucocorticoid, but unsuitable life-time service.Topical therapy selects appropriate dosage forms and medicine according to skin lesion situation.Subacute, chronic eczema applies suitable glucocorticoid cream, burnt oil-like formulations or immunomodulator, as Tacrolimus paste, pimecrolimus ointment.Secondary infection person's added with antibiotic preparation.Also often can eat the food of damp eliminating removing toxic substances, carry out dietetic therapy.Generally speaking, the Therapeutic Method of eczema is a lot, but will thoroughly cure difficult, many times contains potent hormone in those so-called folk prescriptions, though effective in the short time, but is definitely more harm than good for long-range treatment.
Chinese invention patent application 201410405955.5 relates to a kind of externally-applied liniment for the treatment of eczema, and this liniment comprises following Chinese crude drug: Cortex Moutan, Radix Sanguisorbae, Semen Plantaginis, Radix Sophorae Flavescentis, Os Draconis, Herba Artemisiae Annuae, Fructus Cnidii, Fructus Gardeniae, Flos Caryophylli, Radix Glycyrrhizae, Cortex Phellodendri, Rhizoma Coptidis and Chinese liquor.Eczema is had to the effect for the treatment of rapidly, but be difficult to radical cure.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of eczema and preparation method thereof, this Chinese medicine composition has effect of detoxifying and relieving itching, promoting diuresis to eliminate damp pathogen, can effectively treat acute and chronic eczema.
For realizing object of the present invention, technical solution of the present invention is as follows:
The Chinese medicine composition for the treatment of eczema provided by the invention comprises the Chinese crude drug of following weight portion:
Folium Mori 4-24 part, Cortex Phellodendri 5-15 part, Fructus Kochiae 10-15 part, Radix Sophorae Flavescentis 4-14 part, Fructus Cnidii 2-10 part, Radix Et Rhizoma Rhei 4-10 part, Radix Scutellariae 3-6 part, Radix Gentianae 2-6 part, Rhizoma Atractylodis 2-8 part, Poria 4-10 part, Radix Paeoniae Rubra 5-9 part, Semen Plantaginis 6-12 part, Fructus Evodiae 2-6 part and Radix Glycyrrhizae 6-16 part.
Further, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
4 parts, Folium Mori, Cortex Phellodendri 5 parts, the Fructus Kochiae 10 parts, Radix Sophorae Flavescentis 4 parts, Fructus Cnidii 2 parts, Radix Et Rhizoma Rhei 4 parts, Radix Scutellariae 3 parts, Radix Gentianae 2 parts, Rhizoma Atractylodis 2 parts, 4 parts, Poria, Radix Paeoniae Rubra 5 parts, Semen Plantaginis 6 parts, Fructus Evodiae 2 parts and 6 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
24 parts, Folium Mori, Cortex Phellodendri 15 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 14 parts, Fructus Cnidii 10 parts, Radix Et Rhizoma Rhei 10 parts, Radix Scutellariae 6 parts, Radix Gentianae 6 parts, Rhizoma Atractylodis 8 parts, 10 parts, Poria, Radix Paeoniae Rubra 9 parts, Semen Plantaginis 12 parts, Fructus Evodiae 6 parts and 16 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
18 parts, Folium Mori, Cortex Phellodendri 8 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 10 parts, Fructus Cnidii 6 parts, Radix Et Rhizoma Rhei 8 parts, Radix Scutellariae 5 parts, Radix Gentianae 4 parts, Rhizoma Atractylodis 4 parts, 6 parts, Poria, Radix Paeoniae Rubra 7 parts, Semen Plantaginis 8 parts, Fructus Evodiae 4 parts and 10 parts, Radix Glycyrrhizae.
The Chinese medicine composition for the treatment of eczema provided by the invention makes ointment, gel, ointment or cream.
In addition, present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of eczema, comprise the following steps:
Step 1, get Folium Mori, wash away impurity, under 65 DEG C of hot blasts dry 4 hours, controls moisture is 4-6%, pulverizes, and mistake 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.8MPa, charging rate is 32mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
Step 2, Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae and Radix Glycyrrhizae to be pulverized and mixed, add above-mentioned coarse powder 8-11 purified water doubly, decoct 2-3 time, each 1-3 hour, filter, merging filtrate, when filtrate being concentrated into 55 DEG C-65 DEG C, relative density is the water extracting liquid of 1.15-1.20, for subsequent use;
Step 3, Fructus Cnidii and Rhizoma Atractylodis to be pulverized and mixed, adding above-mentioned coarse powder 4-7 times concentration is the ethanol of 80-90%, reflux, extract, 2-3 time, each 5-8 hour, filter, merging filtrate, by filtrate decompression distillation removing ethanol, and be concentrated into the alcohol extraction concentrated solution that relative density at 55 DEG C-65 DEG C is 1.15-1.20, for subsequent use;
The water extracting liquid that step 4, the Ultra-fine Powder of Mulberry Leaves and the step 2 that step 1 are obtained obtain and the alcohol extraction concentrated solution that step 3 obtains mix, and dry, pulverize, and cross 100-200 mesh sieve, are Chinese medicine composition of the present invention.
Source, the nature and flavor of Chinese prescription of the present invention Chinese crude drug used, return through and effect:
Folium Mori: this product is the dried leaves of moraceae plants Mulberry.Bitter in the mouth, sweet, cold nature; Return lung, Liver Channel; Wind and heat dispersing, liver heat removing and eyesight improving, cooling blood for hemostasis.
Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.
The Fructus Kochiae: this product is the dry mature fruit of chenopod Fructus Kochiae.Acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel; Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis.Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.
Fructus Cnidii: be the fruit of samphire cnidium monnieri.Acrid in the mouth, hardship, warm in nature; Slightly poisonous.Return kidney channel.Warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.
Radix Et Rhizoma Rhei: be the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Radix Scutellariae: be the root of Labiatae Scutellaria herbaceos perennial, bitter in the mouth, cold in nature, heat clearing and damp drying, eliminating fire and detoxication, hemostasis.
Radix Gentianae: be the root of Gentianaceae, Gentiana perennial herb, bitter in the mouth, cold in nature.Return liver, gallbladder meridian; Heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened.
Rhizoma Atractylodis: be the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Poria: be the dry sclerotia of Polyporaceae plant Poria.Sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Rubra or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Semen Plantaginis: be the seed of Plantaginaceae plant Herba Plantaginis or Plantago depressa Willd.Sweet in the mouth, cold nature.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.
Fructus Evodiae: be the immature fruit of rutaceae Fructus Evodiae.Acrid in the mouth, hardship, hot in nature; Slightly poisonous.Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention to the dialectical cognition of eczema, follows the compatibility theory of Chinese medicine according to the traditional Chinese medical science, facilitating the easy-to-use and preparation of stable curative effect, enhancing the use amount of medical material to make.This prescription is with Folium Mori, Cortex Phellodendri, the Fructus Kochiae for monarch drug, removing toxic substances pathogenic fire purging, dispelling wind for relieving itching; With Radix Sophorae Flavescentis, Fructus Cnidii, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Rhizoma Atractylodis for ministerial drug, heat clearing and damp drying, eliminating blood stasis and inducing menstruation; With Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae for adjuvant drug, promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; With Radix Glycyrrhizae for making medicine, the coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, and complement each other, synergism, plays the effect such as sterilizing and itch-relieving, promoting diuresis to eliminate damp pathogen altogether, has very significant curative effect to eczema.
Compared with prior art, beneficial effect of the present invention is summarized as follows:
Chinese medicine of the present invention, for obtaining through the summary of clinical trial for many years, is considered eczema complex genesis, existing inside of human body reason, is also had the factor of outside bacterial virus.The beneficial effect of Chinese medicine composition of the present invention comprise can effectively heat clearing away, damp eliminating, dispel the wind, antipruritic, sterilization, anti-erosion, inside and outside take into account, have short treating period, instant effect, toxic and side effects are little, relapse rate is low.In addition, simple and easy to do, the preparation efficacy stability of its preparation technology, be easy to apply.
Detailed description of the invention
Below will the present invention is described further by specific embodiment, it will be understood by those skilled in the art that the present invention also can make other similar changes and obtains similar result and do not depart from content of the present invention and scope except following examples.
Embodiment one
The embodiment of the present invention 1 Chinese medicine composition comprises the Chinese crude drug of following weight portion:
4 parts, Folium Mori, Cortex Phellodendri 5 parts, the Fructus Kochiae 10 parts, Radix Sophorae Flavescentis 4 parts, Fructus Cnidii 2 parts, Radix Et Rhizoma Rhei 4 parts, Radix Scutellariae 3 parts, Radix Gentianae 2 parts, Rhizoma Atractylodis 2 parts, 4 parts, Poria, Radix Paeoniae Rubra 5 parts, Semen Plantaginis 6 parts, Fructus Evodiae 2 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step 1, get Folium Mori, wash away impurity, under 65 DEG C of hot blasts dry 4 hours, controlling moisture is 4%, pulverizes, and crosses 40 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.8MPa, charging rate is 32mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
Step 2, Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae and Radix Glycyrrhizae to be pulverized and mixed, add the purified water of above-mentioned coarse powder 8 times, decoct 2 times, each 1 hour, filter, merging filtrate, when filtrate being concentrated into 55 DEG C, relative density is the water extracting liquid of 1.15, for subsequent use;
Step 3, Fructus Cnidii and Rhizoma Atractylodis are pulverized and mixed, adding above-mentioned coarse powder 4 times of concentration is the ethanol of 80%, reflux, extract, 2 times, each 5 hours, filter, merging filtrate, by filtrate decompression distillation removing ethanol, and be concentrated into the alcohol extraction concentrated solution that relative density at 55 DEG C is 1.15, for subsequent use;
The water extracting liquid that step 4, the Ultra-fine Powder of Mulberry Leaves and the step 2 that step 1 are obtained obtain and the alcohol extraction concentrated solution that step 3 obtains mix, and dry, pulverize, and cross 100 mesh sieves, add corresponding adjuvant, make ointment.
Embodiment two
The embodiment of the present invention 2 Chinese medicine composition comprises the Chinese crude drug of following weight portion:
24 parts, Folium Mori, Cortex Phellodendri 15 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 14 parts, Fructus Cnidii 10 parts, Radix Et Rhizoma Rhei 10 parts, Radix Scutellariae 6 parts, Radix Gentianae 6 parts, Rhizoma Atractylodis 8 parts, 10 parts, Poria, Radix Paeoniae Rubra 9 parts, Semen Plantaginis 12 parts, Fructus Evodiae 6 parts and 16 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step 1, get Folium Mori, wash away impurity, under 65 DEG C of hot blasts dry 4 hours, controlling moisture is 5%, pulverizes, and crosses 60 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.8MPa, charging rate is 32mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
Step 2, Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae and Radix Glycyrrhizae to be pulverized and mixed, add the purified water of above-mentioned coarse powder 10 times, decoct 2 times, each 2 hours, filter, merging filtrate, when filtrate being concentrated into 60 DEG C, relative density is the water extracting liquid of 1.18, for subsequent use;
Step 3, Fructus Cnidii and Rhizoma Atractylodis are pulverized and mixed, adding above-mentioned coarse powder 5 times of concentration is the ethanol of 85%, reflux, extract, 2 times, each 6 hours, filter, merging filtrate, by filtrate decompression distillation removing ethanol, and be concentrated into the alcohol extraction concentrated solution that relative density at 60 DEG C is 1.18, for subsequent use;
The water extracting liquid that step 4, the Ultra-fine Powder of Mulberry Leaves and the step 2 that step 1 are obtained obtain and the alcohol extraction concentrated solution that step 3 obtains mix, and dry, pulverize, and cross 140 mesh sieves, add corresponding adjuvant, make cream.
Embodiment three
The embodiment of the present invention 3 Chinese medicine composition comprises the Chinese crude drug of following weight portion:
18 parts, Folium Mori, Cortex Phellodendri 8 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 10 parts, Fructus Cnidii 6 parts, Radix Et Rhizoma Rhei 8 parts, Radix Scutellariae 5 parts, Radix Gentianae 4 parts, Rhizoma Atractylodis 4 parts, 6 parts, Poria, Radix Paeoniae Rubra 7 parts, Semen Plantaginis 8 parts, Fructus Evodiae 4 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step 1, get Folium Mori, wash away impurity, under 65 DEG C of hot blasts dry 4 hours, controlling moisture is 6%, pulverizes, and crosses 60 mesh sieves, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.8MPa, charging rate is 32mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
Step 2, Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae and Radix Glycyrrhizae to be pulverized and mixed, add the purified water of above-mentioned coarse powder 11 times, decoct 3 times, each 3 hours, filter, merging filtrate, when filtrate being concentrated into 65 DEG C, relative density is the water extracting liquid of 1.20, for subsequent use;
Step 3, Fructus Cnidii and Rhizoma Atractylodis are pulverized and mixed, adding above-mentioned coarse powder 7 times of concentration is the ethanol of 90%, reflux, extract, 3 times, each 8 hours, filter, merging filtrate, by filtrate decompression distillation removing ethanol, and be concentrated into the alcohol extraction concentrated solution that relative density at 65 DEG C is 1.20, for subsequent use;
The water extracting liquid that step 4, the Ultra-fine Powder of Mulberry Leaves and the step 2 that step 1 are obtained obtain and the alcohol extraction concentrated solution that step 3 obtains mix, and dry, pulverize, and cross 200 mesh sieves, add corresponding adjuvant, make gel.
Chinese medicine composition pharmacodynamic study of the present invention:
Test example one: Chinese medicine composition of the present invention is to the influence research of mice eczema
1, experiment purpose and method
Object: according to the requirement of " new Chinese medicine pharmaceutical research guide ", studies the Pharmacodynamics of Chinese medicine composition of the present invention in treatment eczema.Take the embodiment of the present invention one gained Chinese medicine ointment, by tissue pathology checking, observe its high, medium and low dosage to the impact of chronic eczema mouse model.
Method: (company of dimension tonneau China provides to choose 72 BALB/c mouse; Body weight is 28-32g), remove wherein 60 mice same positions ventral seta (about 2cm × 2cm) with electric hair cutter.After 1 day, measure 0.5%2,4-dinitrochlorobenzene (DNCB) solution 20 μ l with sample injector, be applied in wherein 60 mouse web portion cropping districts and excite sensitization, excited once every 3 days, totally four times, set up chronic eczema mouse model.Other 12 non-unhairing mices are Normal group.
The chronic eczema mouse model established is divided into 5 groups at random, is respectively the high, medium and low dosage group of Chinese medicine composition of the present invention, PIYANPING group and model group.High, medium and low dosage component does not give ointment process prepared by 30mg/Kg, 15mg/Kg, 5mg/Kg embodiment of the present invention one, is applied to mouse skin Sensitizing area, every day 2 times, continuous use 15 days; PIYANPING group gives 20mg/Kg PIYANPING, and (China Resources Sanjiu Medical & Pharmaceutical Co., Ltd. produces; The accurate word H44024170 of traditional Chinese medicines), model group gives the process of isometric(al) normal saline, and condition is with high, medium and low dosage group.Medication is after 15 days, and clip excites position and control group mice skin, steeps in 10% formalin, paraffin embedding, and hematoxylin-eosin (H-E) dyes, and does histopathological examination, calculates each group model unit are inflammatory cell quantity.Collection of specimens, at duration of test, is weighed in weekly once.
Statistical procedures test data all adopts mean ± standard deviation to represent, group difference significance t inspection is compared, and P<0.05 is for there being significant difference.SPSS19.0 statistical software is adopted to carry out date processing.
2, experimental result: as shown in table 1.
Table 1 Eczema Model intradermal inflammatory cell count ratio comparatively
| Group | Dosage (mg/Kg) | Quantity | Inflammatory cell counts |
| Normal group | - | 12 | 27.962±6.012 |
| Model group | - | 12 | 83.204±10.416 △△ |
| PIYANPING group | 20 | 12 | 54.330±8.044 ▲▲ |
| High dose group | 30 | 12 | 31.396±7.920 ▲▲ |
| Middle dosage group | 15 | 12 | 47.354±9.016 ▲▲ |
| Low dose group | 5 | 12 | 56.320±7.890 ▲▲ |
Note:
▲compare with model group, p<0.05;
▲ ▲compare with model group, p<0.01;
△ △compare with Normal group, p<0.01.
3, conclusion
This experiment judges the curative effect of Chinese medicine composition of the present invention in eczema by the impact of the high, medium and low dosage of gained Chinese medicine composition ointment on mice inflammatory cell amount in the research embodiment of the present invention one.First, this experiment makes experimental animal with 72 mices.Administration in continuous 15 days, none is dead for mice, and put to death each internal organs of mice anatomic observation and do not find toxic reaction, Mouse Weight is also without significant change.Administration group and control group mice are without any difference.Wherein 60 mouse part skins are with after DNCB process, and local skin is coarse, thicken, lichenization, and pathological manifestations meets the symptom of Chronic dermatitis, and to be used for the treatment of eczema patients situation similar to Chinese medicine composition of the present invention, other 12 then as a control group.The remarkable increase (P<0.01) compared with Normal group of model group mice inflammatory cell amount, after DNCB process is described, mouse web portion cell produces inflammatory reaction, modeling success.The inflammatory cell amount of high, medium and low dosage group is compared with model group, and each group significantly can be reduced inflammatory cell amount (P<0.05), and wherein high dose group almost reaches levels found in normal controls.PIYANPING group treatment level is a little less than the middle and high dosage group of Chinese medicine composition of the present invention.Visible, three dosage groups of Chinese medicine composition of the present invention all can reduce the inflammatory cell amount of rat, especially better with middle high dose effect, and have certain safety, have the effect of good treatment chronic eczema.
Test two: Chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of eczema clinical volunteers patient
One, case and diagnostic criteria
1, Western medicine diagnose standard:
Acute eczema: erythra pleomorphism, visible erythema, pimple, mound scar rash, water scar, erosion, scratch, knot are crazy about, are oozed out, and it is sick anxious, conscious scorching hot, violent pruritus.Erythra is often symmetrical, is common with places such as women's head-ornaments, distal limbs, scrotum, can general whole body, can develop into subacute eczema or chronic eczema, time light time heavy, repeatedly do not heal.
Subacute eczema: erythra is crazy about based on inflamed papules, squama, knot, has dark red or pale red patch, only has minority mound scar rash and erosion, or has mild infiltration, conscious pruritus.
2, tcm diagnosis standard:
With reference to " traditional Chinese medical science skin disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine issues for 1994), " tcm syndrome Differential Diagnosis " (People's Health Publisher in " National Standard of the People's Republic of China's tcm clinical practice diagnosis and treatment term " (GB/T13.20), " People's Republic of China's traditional Chinese medicine industry standard ", in JIUYUE, 2002 version) meet the damp and hot pattern of syndrome of dermatosis: primary symptom: the acute course of disease or chronic course of disease acute attack, pruritus is heavier, ooze out obviously, companion's skin erythema, scorching hot.Secondary disease: vexed, thirsty, yellowish urine, large dry stool, red tongue, yellow and greasy fur, rolling pulse.Possess above primary symptom and secondary disease more than 2 persons, diagnosable is this syndrome
Two, clinical trial
1, physical data
All selected eczema patients are clinical volunteers, totally 120, and the age is 18 years old-63 years old, and 37 years old mean age, M-F is 1:1.Be divided into treatment group and matched group at random, often organize 60 people.Two groups of influence factors such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Treatment group: take ointment prepared by the embodiment of the present invention one, smear 2 times on 1st, evaluate curative effect after being used in conjunction 15 days.
Matched group: (China Resources Sanjiu Medical & Pharmaceutical Co., Ltd. produces to use PIYANPING; The accurate word H44024170 of traditional Chinese medicines), within 1st, smear 2 times, after being used in conjunction 15 days, evaluate curative effect.
3, evaluation of clinical curative effect standard
1) curative effect determinate standard judges according to " new Chinese medicine guideline of clinical investigations ".
Scoring before therapeutic index=(before treatment scoring after scoring-treatment)/treatment
(1) clinical recovery: therapeutic index is 100%-95%;
(2) effective: therapeutic index is 60%-94%;
(3) effective: therapeutic index is 30%-59%;
(4) invalid: therapeutic index is 0-30%.
Total effective rate=(clinical recovery number of cases+effective number of cases+effectively number of cases)/(this organizes total number of cases × 100%).
2) pruritus scoring
0 point: without any pruritus.
1 point: pruritus once in a while, not medication, does not affect learning life.
2 points: paroxysmal pruritus, time light time heavy, affect sleep learning and lives, need medication.
3 points: violent pruritus, have a strong impact on work and study life.
4, therapeutic outcome, as shown in table 2.
Table 2 therapeutic effect
| Group | Number of cases | Clinical recovery | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 60 | 40 | 4 | 2 | 14 | 76.7％ |
| Treatment group | 60 | 48 | 6 | 3 | 3 | 95.0％ |
5, conclusion
The clinical volunteers patient of this clinical trial is eczema patients, does not comprise the patient that Zeng Quanshen in nearly 2 weeks uses glucocorticosteroid hormone or once used antihistaminic or external 17-hydroxy-11-dehydrocorticosterone preparation in 1 week.Eczema can betide any age, therefore selects age bracket span comparatively large, 18-65 year between; This test takes PIYANPING as a control group.Also can find out from clinical cure rate, obvious effective rate and total effective rate, the total effective rate of Chinese medicine composition of the present invention is greater than 90%, far above the total effective rate of matched group.Whether eczema is the disease of the stubbornness of easy recurrent exerbation, therefore within 2 weeks after medication, again observe the state of an illness and recur, and finds none recurrence case.The clinical cure rate for the treatment of group is also apparently higher than matched group.As can be seen here, Chinese medicine composition of the present invention, relative to Western medicine, has significant curative effect to treatment eczema.All experimenters are through physical examination, and the security inspections such as blood, routine urinalysis, electrocardiogram, hepatic and renal function, it is safe and effective that further proved invention is used for the treatment of eczema, has the value applied.
Claims (6)
1. treat a Chinese medicine composition for eczema, it is characterized in that, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
Folium Mori 4-24 part, Cortex Phellodendri 5-15 part, Fructus Kochiae 10-15 part, Radix Sophorae Flavescentis 4-14 part, Fructus Cnidii 2-10 part, Radix Et Rhizoma Rhei 4-10 part, Radix Scutellariae 3-6 part, Radix Gentianae 2-6 part, Rhizoma Atractylodis 2-8 part, Poria 4-10 part, Radix Paeoniae Rubra 5-9 part, Semen Plantaginis 6-12 part, Fructus Evodiae 2-6 part and Radix Glycyrrhizae 6-16 part.
2. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
4 parts, Folium Mori, Cortex Phellodendri 5 parts, the Fructus Kochiae 10 parts, Radix Sophorae Flavescentis 4 parts, Fructus Cnidii 2 parts, Radix Et Rhizoma Rhei 4 parts, Radix Scutellariae 3 parts, Radix Gentianae 2 parts, Rhizoma Atractylodis 2 parts, 4 parts, Poria, Radix Paeoniae Rubra 5 parts, Semen Plantaginis 6 parts, Fructus Evodiae 2 parts and 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition of described treatment eczema according to claim 1, it is characterized in that, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
24 parts, Folium Mori, Cortex Phellodendri 15 parts, the Fructus Kochiae 15 parts, Radix Sophorae Flavescentis 14 parts, Fructus Cnidii 10 parts, Radix Et Rhizoma Rhei 10 parts, Radix Scutellariae 6 parts, Radix Gentianae 6 parts, Rhizoma Atractylodis 8 parts, 10 parts, Poria, Radix Paeoniae Rubra 9 parts, Semen Plantaginis 12 parts, Fructus Evodiae 6 parts and 16 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition comprises the Chinese crude drug of following weight portion:
18 parts, Folium Mori, Cortex Phellodendri 8 parts, the Fructus Kochiae 12 parts, Radix Sophorae Flavescentis 10 parts, Fructus Cnidii 6 parts, Radix Et Rhizoma Rhei 8 parts, Radix Scutellariae 5 parts, Radix Gentianae 4 parts, Rhizoma Atractylodis 4 parts, 6 parts, Poria, Radix Paeoniae Rubra 7 parts, Semen Plantaginis 8 parts, Fructus Evodiae 4 parts and 10 parts, Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-4, it is characterized in that, described Chinese medicine composition is made into: ointment, gel, ointment or cream.
6., according to the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-5, it is characterized in that, the preparation technology of described Chinese medicine composition comprises the following steps:
Step 1, get Folium Mori, wash away impurity, under 65 DEG C of hot blasts dry 4 hours, controls moisture is 4-6%, pulverizes, and mistake 40-60 mesh sieve, obtains coarse powder; Coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.8MPa, charging rate is 32mg/s, carries out micronizing respectively after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
Step 2, Cortex Phellodendri, the Fructus Kochiae, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Gentianae, Poria, Radix Paeoniae Rubra, Semen Plantaginis, Fructus Evodiae and Radix Glycyrrhizae to be pulverized and mixed, add above-mentioned coarse powder 8-11 purified water doubly, decoct 2-3 time, each 1-3 hour, filter, merging filtrate, when filtrate being concentrated into 55 DEG C-65 DEG C, relative density is the water extracting liquid of 1.15-1.20, for subsequent use;
Step 3, Fructus Cnidii and Rhizoma Atractylodis to be pulverized and mixed, adding above-mentioned coarse powder 4-7 times concentration is the ethanol of 80-90%, reflux, extract, 2-3 time, each 5-8 hour, filter, merging filtrate, by filtrate decompression distillation removing ethanol, and be concentrated into the alcohol extraction concentrated solution that relative density at 55 DEG C-65 DEG C is 1.15-1.20, for subsequent use;
The water extracting liquid that step 4, the Ultra-fine Powder of Mulberry Leaves and the step 2 that step 1 are obtained obtain and the alcohol extraction concentrated solution that step 3 obtains mix, and dry, pulverize, and cross 100-200 mesh sieve, are Chinese medicine composition of the present invention.
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| CN106668250A (en) * | 2017-03-14 | 2017-05-17 | 四川香龙丹医药科技有限公司 | Pharmaceutical composition for treating dermatitis and eczema |
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