CN101670026A - Chinese and western medicine composition for treating canine parvovirus infection and preparation method thereof - Google Patents
Chinese and western medicine composition for treating canine parvovirus infection and preparation method thereof Download PDFInfo
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- CN101670026A CN101670026A CN200910070289A CN200910070289A CN101670026A CN 101670026 A CN101670026 A CN 101670026A CN 200910070289 A CN200910070289 A CN 200910070289A CN 200910070289 A CN200910070289 A CN 200910070289A CN 101670026 A CN101670026 A CN 101670026A
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Abstract
The invention provides a Chinese and western medicine composition for treating canine parvovirus infection and a preparation method thereof. The composition contains the following ingredients in portion by weight: 15-30 portions of radix puerariae, 15-30 portions of rhizoma coptidis, 15-30 portions of radix scutellariae, 15-30 portions of phellodendron, 15-30 portions of rhubarb, 15-30 portions ofChinese pulsatilla root, 15-30 portions of sanguisorba, 15-30 portions of alisma orientale, 15-30 portions of radix paeoniae alba, 30-40 portions of myrobalan and 2-5 portions of ofloxaction. The preparation method comprises the following steps: putting the Chinese medicinal materials in proportion in water for decocting; standing and collecting supernatant and then concentrating until a relativedensity of the supernatant is 1.0-1.3; then adding alcohol aqueous solution, wherein the volume percentage concentration of the alcohol aqueous solution is 50-80; standing for 24 hours, collecting the filtrate as well as recycling and concentrating the alcohol; and adding the ofloxaction into the concentrated liquid. The Chinese and western medicine composition has low toxicity and can effectively prevent and treat the canine parvovirus infection.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, especially a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease and preparation method thereof.
Background technology
Canine parvovirus disease is a kind of infectious disease with height contact of dog.The generation of this disease is of all ages, kind, sex, and the dog that whether carried out healthy immunity all can be taken place, and is more to the morbidity of 90 age in days dogs with ablactation clinically.Primary disease do not have an obvious seasonal, morbidity is more down for environment such as cold weather, temperature cataclysm, crowded, sanitary condition difference, accompanying infection can increase the weight of the state of an illness, improves mortality rate.Canine viral enteritis can be divided into enteritis type and myocarditis type clinically, and is the most common with enteritis type.The sick dog of myocarditis type does not have obvious clinical symptoms, often shows as sudden onset, dyspnea, and heart failure, it is promptly dead at short notice often to have little time treatment.
Be used for the treatment of at present and what prevent enteritis canine parvovirus mainly is serum and all kinds of antibiotic, antibiotic is easy to generate drug resistance, though can induce sweat fast, being in harmonious proportion body function aspect does not have effect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease.
Another technical problem to be solved by this invention is to provide the preparation method of the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease, comprise Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, by its parts by weight Radix Puerariae 15-30 part, Rhizoma Coptidis 15-30 part, Radix Scutellariae 15-30 part, Cortex Phellodendri 15-30 part, Radix Et Rhizoma Rhei 15-30 part, Radix Pulsatillae 15-30 part, Radix Sanguisorbae 15-30 part, Rhizoma Alismatis 15-30 part, Radix Paeoniae Alba 15-30 part, Fructus Chebulae 30-40 part; Ofloxacin 2-5 part.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 18 parts of its parts by weight Radix Puerariaes, 18 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 3 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 15 parts of its parts by weight Radix Puerariaes, 15 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 15 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 15 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 5 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 30 parts of its parts by weight Radix Puerariaes, 30 parts of Rhizoma Coptidis, 30 parts of Radix Scutellariaes, 30 parts of Cortex Phellodendris, 30 parts of Radix Et Rhizoma Rhei, 30 parts of the Radix Pulsatillaes, 30 parts of Radix Sanguisorbaes, 30 parts of Rhizoma Alismatis, 30 parts of the Radix Paeoniae Albas, 40 parts of Fructus Chebulaes; 2 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 20 parts of its parts by weight Radix Puerariaes, 20 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 20 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 4 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 25 parts of its parts by weight Radix Puerariaes, 25 parts of Rhizoma Coptidis, 25 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 3 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 18 parts of its parts by weight Radix Puerariaes, 18 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 4 parts of ofloxacins.
Preferably, the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is by 22 parts of its parts by weight Radix Puerariaes, 22 parts of Rhizoma Coptidis, 22 parts of Radix Scutellariaes, 22 parts of Cortex Phellodendris, 22 parts of Radix Et Rhizoma Rhei, 22 parts of the Radix Pulsatillaes, 22 parts of Radix Sanguisorbaes, 22 parts of Rhizoma Alismatis, 22 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 5 parts of ofloxacins.
The Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease is brown liquid, gas perfume (or spice), mildly bitter flavor, suffering.
The preparation method of above-mentioned treatment canine parvovirus disease Chinese and western medicinal composition, concrete preparation process is as follows:
(1) gets Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae by above-mentioned parts by weight and be raw material;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 5～12 times of its gross weights boils, boiled 30～60 minutes, get filtrate, residue adds 5～10 times water boil 30～50 minutes again, get filtrate, leave standstill and be concentrated into relative density 1.0～1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%～80%, left standstill 24 hours, and got filtrate recycling ethanol and be concentrated into relative density 1.0-1.3;
(3) get ofloxacin by above-mentioned parts by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 110-130ml taking ethylparaben of solution 0.5～2g in (3), with ethanol 5～15ml dissolving, add propylene glycol 5～10ml and stir, add sodium benzoate 0.2～0.6g again and be stirred well to dissolving, add in the described solution, promptly get product.
The preparation method of above-mentioned treatment canine parvovirus disease Chinese and western medicinal composition, the dosage form of the Chinese and western medicinal composition that described step is made is an oral solution.
The Chinese and western medicinal composition that the preparation method of above-mentioned treatment canine parvovirus disease Chinese and western medicinal composition is made when being used for the treatment of canine parvovirus disease, gavages by every dog 50-100ml, and 3-5 days is a course of treatment.
The invention has the beneficial effects as follows:
(1) Chinese and western medicinal composition toxicity of the present invention is little, and cost is lower, can effectively play prevention and therapeutical effect to canine parvovirus disease, goes back the anti-adversity ability of enhancing body simultaneously;
(2) Chinese and western medicinal composition of the present invention is simple to operate, easy to use, and a people can operate;
(3) Chinese and western medicinal composition of the present invention is made oral solution because of it, and ingredient absorbs fast, safety;
(4) preparation method of the present invention is simple, is fit to requirements of large-scale industrial production.
The specific embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is further described.
Embodiment 1
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 18 parts of Radix Puerariaes, 18 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 35 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 8 times of its gross weights boils, boiled 45 minutes, get filtrate, residue adds 6 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.1 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.05;
(3) get 3 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 120ml taking ethylparaben of solution 0.6g in (3),, add propylene glycol 5ml and stir, add sodium benzoate 0.5g again and be stirred well to dissolving, add in the described solution, make the oral administration solution dosage form with ethanol 7ml dissolving.
Embodiment 2
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 15 parts of Radix Puerariaes, 15 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 15 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 15 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 30 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 8 times of its gross weights boils, boiled 50 minutes, get filtrate, residue adds 8 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.1 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.1;
(3) get 5 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 123ml taking ethylparaben of solution 0.6g in (3),, add propylene glycol 10ml and stir, add sodium benzoate 0.6g again and be stirred well to dissolving, add in the described solution, make the oral administration solution dosage form with ethanol 5ml dissolving.
Embodiment 3
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 30 parts of Radix Puerariaes, 30 parts of Rhizoma Coptidis, 30 parts of Radix Scutellariaes, 30 parts of Cortex Phellodendris, 30 parts of Radix Et Rhizoma Rhei, 30 parts of the Radix Pulsatillaes, 30 parts of Radix Sanguisorbaes, 30 parts of Rhizoma Alismatis, 30 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 40 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 8 times of its gross weights boils, boiled 50 minutes, get filtrate, residue adds 6 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.2 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.2;
(3) get 2 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 120ml taking ethylparaben of solution 0.5g in (3),, add propylene glycol 8ml and stir, add sodium benzoate 0.5g again and be stirred well to dissolving, add in the described solution, promptly get product with ethanol 5ml dissolving.
Embodiment 4
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 20 parts of Radix Puerariaes, 20 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 20 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 35 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 8 times of its gross weights boils, boiled 45 minutes, get filtrate, residue adds 6 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.1 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.08;
(3) get 4 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 125ml taking ethylparaben of solution 0.6g in (3),, add propylene glycol 5ml and stir, add sodium benzoate 0.5g again and be stirred well to dissolving, add in the described solution, make the oral administration solution dosage form with ethanol 7ml dissolving.
Embodiment 5
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 25 parts of Radix Puerariaes, 25 parts of Rhizoma Coptidis, 25 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 35 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 8 times of its gross weights boils, boiled 60 minutes, get filtrate, residue adds 6 times water boil 45 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.2 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 60%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.3;
(3) get 3 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 115ml taking ethylparaben of solution 0.6g in (3),, add propylene glycol 5ml and stir, add sodium benzoate 0.5g again and be stirred well to dissolving, add in the described solution, promptly get product with ethanol 7ml dissolving.
Embodiment 6
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) gets 18 parts of Radix Puerariaes, 18 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, Fructus Chebulae by weight and be raw material for 30 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 5 times of its gross weights boils, boiled 30 minutes, get filtrate, residue adds 10 times water boil 50 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.0 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 80%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.0;
(3) get 4 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 110ml taking ethylparaben of solution 2g in (3),, add propylene glycol 7ml and stir, add sodium benzoate 0.2g again and be stirred well to dissolving, add in the described solution, promptly get product with ethanol 15ml dissolving.
Embodiment 7
A kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease comprises Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, and concrete preparation method is as follows:
(1) get 22 parts of Radix Puerariaes, 22 parts of Rhizoma Coptidis, 22 parts of Radix Scutellariaes, 22 parts of Cortex Phellodendris, 22 parts of Radix Et Rhizoma Rhei, 22 parts of the Radix Pulsatillaes, 22 parts of Radix Sanguisorbaes, 22 parts of Rhizoma Alismatis, 22 parts of the Radix Paeoniae Albas by weight, the Fructus Chebulae is a raw material for 30 parts;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 12 times of its gross weights boils, boiled 45 minutes, get filtrate, residue adds 5 times water boil 30 minutes again, gets filtrate, leaves standstill to be concentrated into relative density 1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%, leaves standstill 24 hours, gets filtrate recycling ethanol and is concentrated into relative density 1.25;
(3) get 5 parts of ofloxacins by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 130ml taking ethylparaben of solution 1.3g in (3),, add propylene glycol 6ml and stir, add sodium benzoate 0.4g again and be stirred well to dissolving, add in the described solution, make the oral administration solution dosage form with ethanol 11ml dissolving.
In the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease, Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae all meet the relevant regulations in " Chinese veterinary drug allusion quotation ".
Rhizoma Coptidis, Radix Scutellariae, the Radix Pulsatillae, Radix Et Rhizoma Rhei and Cortex Phellodendri have inhibitory action to multiple gram positive bacteria and negative bacterium in the Chinese and western medicinal composition of above-mentioned treatment canine parvovirus disease, comprising escherichia coli, staphylococcus, Hemolytic streptococcus, dysentery bacterium, Salmonella, vibrio cholera, bacillus pyocyaneus etc. are all had good inhibition effect, but heat-clearing and toxic substances removing, anti-inflammatory analgetic; The hemostasis that can dehumidify of Radix Sanguisorbae, the Radix Paeoniae Alba; Described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae cooperate the Western medicine ofloxacin, and the medicine antibacterial action is strengthened greatly, and the anti-adversity ability of enhancing body significantly improves disease resisting effect.
Canine parvovirus disease is a kind of deadly infectious disease with height contagious infection of dog, be feature with acute hemorrhage enteritis and myocarditis clinically, all can fall ill throughout the year, with the winter-spring season pilosity, toxic amount is the highest in the feces of sick dog, for inquiring into the effective way of control canine parvovirus disease, the selection medication of science, the medicine that selection has sterilization, dampness function carries out prescription, and clinical trial is as follows:
Clinical trial 1
Select three kinds of medicine groups to contrast, i.e. 2% ofloxacin group, the Chinese medicine Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae's group, wherein count 18 parts of Radix Puerariaes by weight, 18 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes, add and leave standstill after water decocts repeatedly, be concentrated into relative density 1.1 (i.e. Chinese medicine composition group in the table) after getting supernatant, the embodiment of the invention 1 described Chinese and western medicinal composition medicine group (i.e. Chinese and Western bound drug group in the table), concrete consumption is by every dog 50ml oral liquid, took continuously 3 days, the result shows that Chinese and Western composition of medicine group curative effect is the highest, table specific as follows:
Result of the test shows, the Chinese and western medicinal composition control canine parvovirus disease effective percentage of above-mentioned treatment canine parvovirus disease is higher than other two kinds, significant difference illustrates that Chinese and western drugs binding ratio folk prescription 2% ofloxacin and Chinese medicine Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae's group have good curative effect.
Clinical trial 2
The blue or green hot mouthful veterinary hospital in west, Tianjin, clinical symptoms: sick performance heating (more than 40 ℃) just, spirit be depressed, do not eat, vomit, and fall ill about one day begins to suffer from diarrhoea, and feces is the hemafecia of coffee color or tomato sauce tinctorial pattern, tenesmus, hemafecia have special fishy odor.The compositions that Application Example 4 is prepared gavages by 100ml, once-a-day, the Canine Parvovirus of intramuscular injection simultaneously antiserum 10ml 1 time/day, injected 3 days continuously, 5% glucose 500ml, VC 4ml, ATP 4ml, CoA 4ml, dexamethasone sodium phosphate 4ml mixes an intravenous drip logotype 5 days, mainly be to supplement the nutrients, prevent that diarrhoea and vomiting from causing dehydration; After 2 days, symptom is obviously improved, and symptom all disappears after 5 days, suffers from the dog recovery from illness.
Above-mentioned detailed description of this a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (10)
1, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease, it is characterized in that: comprise Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae and ofloxacin, by its parts by weight Radix Puerariae 15-30 part, Rhizoma Coptidis 15-30 part, Radix Scutellariae 15-30 part, Cortex Phellodendri 15-30 part, Radix Et Rhizoma Rhei 15-30 part, Radix Pulsatillae 15-30 part, Radix Sanguisorbae 15-30 part, Rhizoma Alismatis 15-30 part, Radix Paeoniae Alba 15-30 part, Fructus Chebulae 30-40 part; Ofloxacin 2-5 part.
2, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 18 parts of its parts by weight Radix Puerariaes, 18 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 3 parts of ofloxacins.
3, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 15 parts of its parts by weight Radix Puerariaes, 15 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 15 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 15 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 5 parts of ofloxacins.
4, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 30 parts of its parts by weight Radix Puerariaes, 30 parts of Rhizoma Coptidis, 30 parts of Radix Scutellariaes, 30 parts of Cortex Phellodendris, 30 parts of Radix Et Rhizoma Rhei, 30 parts of the Radix Pulsatillaes, 30 parts of Radix Sanguisorbaes, 30 parts of Rhizoma Alismatis, 30 parts of the Radix Paeoniae Albas, 40 parts of Fructus Chebulaes; 2 parts of ofloxacins.
5, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 20 parts of its parts by weight Radix Puerariaes, 20 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 20 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 4 parts of ofloxacins.
6, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 25 parts of its parts by weight Radix Puerariaes, 25 parts of Rhizoma Coptidis, 25 parts of Radix Scutellariaes, 25 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 20 parts of the Radix Pulsatillaes, 20 parts of Radix Sanguisorbaes, 20 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 35 parts of Fructus Chebulaes; 3 parts of ofloxacins.
7, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1 is characterized in that: by 18 parts of its parts by weight Radix Puerariaes, 18 parts of Rhizoma Coptidis, 15 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 15 parts of the Radix Pulsatillaes, 15 parts of Radix Sanguisorbaes, 15 parts of Rhizoma Alismatis, 20 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 4 parts of ofloxacins.
8, a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease according to claim 1, it is characterized in that: by 22 parts of its parts by weight Radix Puerariaes, 22 parts of Rhizoma Coptidis, 22 parts of Radix Scutellariaes, 22 parts of Cortex Phellodendris, 22 parts of Radix Et Rhizoma Rhei, 22 parts of the Radix Pulsatillaes, 22 parts of Radix Sanguisorbaes, 22 parts of Rhizoma Alismatis, 22 parts of the Radix Paeoniae Albas, 30 parts of Fructus Chebulaes; 5 parts of ofloxacins.
9, according to the described a kind of Chinese and western medicinal composition for the treatment of canine parvovirus disease of one of claim 1-8, it is characterized in that: be brown liquid, gas perfume (or spice), mildly bitter flavor, suffering.
10, the described a kind of preparation method for the treatment of the canine parvovirus disease Chinese and western medicinal composition of claim 1-9 is characterized in that: concrete preparation process is as follows:
(1) gets Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae by above-mentioned parts by weight and be raw material;
(2) decocting that described Radix Puerariae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Pulsatillae, Radix Sanguisorbae, Rhizoma Alismatis, the Radix Paeoniae Alba, Fructus Chebulae is added 5～12 times of its gross weights boils, boiled 30～60 minutes, get filtrate, residue adds 5～10 times water boil 30～50 minutes again, get filtrate, leave standstill and be concentrated into relative density 1.0～1.3 after getting supernatant, put into ethanol water afterwards, the concentration expressed in percentage by volume of described ethanol water is 50%～80%, left standstill 24 hours, and got filtrate recycling ethanol and be concentrated into relative density 1.0-1.3;
(3) get ofloxacin by above-mentioned parts by weight, use an amount of dissolved in distilled water, add in the concentrated good aforesaid liquid;
(4) set by step make the every 110-130ml taking ethylparaben of solution 0.5～2g in (3), with ethanol 5～15ml dissolving, add propylene glycol 5～10ml and stir, add sodium benzoate 0.2～0.6g again and be stirred well to dissolving, add in the described solution, promptly get product.
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| CN200910070289A CN101670026A (en) | 2009-08-28 | 2009-08-28 | Chinese and western medicine composition for treating canine parvovirus infection and preparation method thereof |
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| CN200910070289A CN101670026A (en) | 2009-08-28 | 2009-08-28 | Chinese and western medicine composition for treating canine parvovirus infection and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104667236A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating canine parvovirus and preparation method of compound water aqua |
| CN105641261A (en) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition for treating yellow scours of newborn piglets and preparation method of traditional Chinese medicinal composition |
| CN106039074A (en) * | 2016-07-12 | 2016-10-26 | 张绪伟 | Tablets for treating canine parvovirus |
| CN112569278A (en) * | 2019-09-29 | 2021-03-30 | 邓雍钲 | Traditional Chinese veterinary medicine formula for treating canine enteritis parvovirus and preparation method thereof |
| JP2021512880A (en) * | 2018-01-31 | 2021-05-20 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of Bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
| CN113730481A (en) * | 2021-08-24 | 2021-12-03 | 河北锦坤动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating canine parvovirus enteritis, suppository and preparation method |
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2009
- 2009-08-28 CN CN200910070289A patent/CN101670026A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641261A (en) * | 2014-11-11 | 2016-06-08 | 天津中敖生物科技有限公司 | Traditional Chinese medicinal composition for treating yellow scours of newborn piglets and preparation method of traditional Chinese medicinal composition |
| CN104667236A (en) * | 2014-12-06 | 2015-06-03 | 湖北文理学院 | Compound water aqua for preventing and treating canine parvovirus and preparation method of compound water aqua |
| CN106039074A (en) * | 2016-07-12 | 2016-10-26 | 张绪伟 | Tablets for treating canine parvovirus |
| JP2021512880A (en) * | 2018-01-31 | 2021-05-20 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of Bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
| JP7021360B2 (en) | 2018-01-31 | 2022-02-16 | スーチュワン インル ウェイトー ファーマスーティカル テクノロジー カンパニー リミテッド | Use of light-vented bulbul extract in the manufacture of drugs to treat viral and / or bacterial diseases |
| CN112569278A (en) * | 2019-09-29 | 2021-03-30 | 邓雍钲 | Traditional Chinese veterinary medicine formula for treating canine enteritis parvovirus and preparation method thereof |
| CN113730481A (en) * | 2021-08-24 | 2021-12-03 | 河北锦坤动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating canine parvovirus enteritis, suppository and preparation method |
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Application publication date: 20100317 |