CN105056405A - Multi-blade collimator, particle ray treatment device, and treatment plan apparatus - Google Patents

Abstract

The objective of the invention lies in providing a multi-blade collimator which is not affected by half shadow and can form higher contrast ratio, and also providing a particle ray treatment device. The multi-blade collimator comprises a blade array (5C), and the blade array (5C) enables one end faces (EL) of a plurality of blade plates (5L) to be aligned with each other and arranged in a thickness direction. The multi-blade collimator also comprises a blade plate driving mechanism (5D), and the blade plate driving mechanism (5D) takes one end face (EL) to drive the plurality of blade plates (5L) in a mode of getting close to or being far from a beam axis (XB). For all blade plates (5L), each blade plate (5L) and the opposite face (PL) of one blade plate (5L) adjacent to the blade plate (5L) in the thickness direction form a plane (PSa) which comprises a first axis (Asa) on the beam axis (XB). The blade plate driving mechanism (5D) drives the blade plates (5L) along a circular rail (OL) which takes a second axis (Asb) on the beam axis (XB), wherein the second axis (Asb) is perpendicular to the beam axis (XB) and the first axis (Asa).

Description

Multi-diaphragm collimator, particle-beam therapeutic apparatus and therapy planning device

The present patent application is international application no is PCT/JP2010/063874, international filing date is on August 17th, 2010, the application number entering National Phase in China is 201080068421.8, the divisional application of the application for a patent for invention that name is called " multi-diaphragm collimator, particle-beam therapeutic apparatus and therapy planning device ".

Technical field

The present invention relates to multi-diaphragm collimator, use the particle-beam therapeutic apparatus of this multi-diaphragm collimator and determine the therapy planning device of working condition of this particle-beam therapeutic apparatus, this multi-diaphragm collimator is applicable to form irradiation field in the particle-beam therapeutic apparatus using charged particle beam.

Background technology

Particle-beam therapeutic be a kind of by using charged particle beam irradiation to as the affected part for the treatment of target to destroy the Therapeutic Method for the treatment of to affected tissue, in order to Bu Shi perienchyma suffers damage, and give affected tissue enough dosage, needs can suitably to the particle-beam therapeutic apparatus that exposure dose, range of exposures (hereinafter, referred to irradiation field) control.Among particle-beam therapeutic apparatus, use comprises in the so-called wide area irradiation type particle-beam therapeutic apparatus of the irradiation mouth of the scanning electro-magnets such as oscillating electromagnetic ferrum, irradiation mouth is utilized to expand irradiation field, and be configured in the multi-diaphragm collimator making in the irradiation field after expansion to change through shape, thus form the irradiation field corresponding with affected part shape.

Multi-diaphragm collimator being arranged so that 2, to be listed in rows of blades thickness direction being laminated with vane plate relative, and by with make each vane plate to relative vane plate close or away from mode drive this vane plate, thus formed predetermined through shape.Therefore, it is possible to by controlling the physical location of each vane plate, can be easy to form irradiation field.But, when carrying out linear drives to vane plate, at the outline portion away from irradiation field center, with dispersal direction charged particle beam irradiation at an angle in a part for vane plate end face, cause the dosage generation seriality of charged particle beam to decay, namely produce so-called penumbra.Thus, consider the diffusion of beam, propose a kind of so-called bullet multi-diaphragm collimator, this bullet multi-diaphragm collimator drives blade with circuit orbit, this blade-shaped becomes carries out with the side of circular arc or cone the shape (for example, referring to patent documentation 1 or 2) that is split to form.

Prior art document

Patent documentation

Patent documentation 1: Japanese Patent Laid-Open No. Sho 60-063500 publication (page 2 upper right, page 2 bottom right ~ page 3 upper left, Fig. 2, Fig. 4)

Patent documentation 2: Japanese Patent Laid-Open No. Sho 63-225199 publication (page 3 bottom right ~ page 4 upper right, the 7th page of lower-left ~ bottom right, Fig. 1 ~ Fig. 3, Figure 12 ~ Figure 13)

Patent documentation 3: Japanese Patent Laid-Open 10-255707 publication (paragraph 0009 ~ 0020, Fig. 1, Fig. 5)

Patent documentation 4: Japanese Patent Laid-Open 2006-166947 publication (paragraph 0015 ~ 0016, Fig. 1)

Summary of the invention

Invent problem to be solved

But, for above-mentioned bullet multi-diaphragm collimator, assuming that use the beam spread by point source.In other words conj.or perhaps, when supposing to use volume source, the situation making diffusion way different because direction is different is not considered.On the other hand, in order to be expanded by irradiation field in the particle ray device using charged particle beam, as shown in patent documentation 3,4, the electric magnet scanned compared with narrow beam to being provided by accelerator is needed.And, due in the plane vertical with beam axis, need as x direction electric magnet and y direction electric magnet, to be arranged at 2 directions respectively electric magnet, therefore, dissimilate in x direction and the starting point of carrying out spreading in y-direction.Therefore, even if apply above-mentioned multi-diaphragm collimator in particle-beam therapeutic apparatus, also can there are the following problems, namely the diffusion way of beam and the inconsistent through shape of multi-diaphragm collimator, produce penumbra thus.

The present invention completes to solve the problem, its object is to obtain a kind of not by penumbra impact and multi-diaphragm collimator and the particle-beam therapeutic apparatus of the higher irradiation field of contrast can be formed.

For the means of dealing with problems

Multi-diaphragm collimator of the present invention is configured in expand in particle beam that irradiation field irradiates, and in the mode be consistent with irradiation object to form above-mentioned irradiation field, this multi-diaphragm collimator comprises: rows of blades, and this rows of blades arranges in a thickness direction to make the mode of multiple vane plate end face alignment, and vane plate driving mechanism, this vane plate driving mechanism is to make the mode of an above-mentioned end face or beam axis away from above-mentioned particle beam close to the beam axis of above-mentioned particle beam, drive multiple above-mentioned vane plate respectively, the feature of this multi-diaphragm collimator is, each above-mentioned vane plate and with the opposite face of its vane plate adjacent be in a thickness direction formed at comprise the 1st axle plane on, 1st axle is set in the 1st position on above-mentioned beam axis, and it is vertical with this beam axis, above-mentioned vane plate driving mechanism drives above-mentioned vane plate along the circular orbit centered by the 2nd axle, 2nd axle is set in the 2nd position on above-mentioned beam axis, and it is vertical with this beam axis and above-mentioned 1st axle.

In addition, particle-beam therapeutic apparatus of the present invention comprises: irradiate mouth, 2 electric magnet that this irradiation mouth utilizes scanning direction different scan the particle beam provided by accelerator, and carry out irradiating to expand irradiation field; And above-mentioned multi-diaphragm collimator, this multi-diaphragm collimator is configured in the particle beam irradiated by above-mentioned irradiation mouth, the feature of this particle-beam therapeutic apparatus is, to make above-mentioned 1st axle consistent with the scan axis of an electric magnet in above-mentioned 2 electric magnet, and the mode making above-mentioned 2nd axle consistent with the scan axis of another electric magnet, configure above-mentioned multi-diaphragm collimator.

In addition, the feature of therapy planning device of the present invention is, comprising: three-dimensional data generation unit, and this three-dimensional data generation unit generates three-dimensional data according to the view data of irradiation object; Illuminate condition setup unit, this illuminate condition setup unit sets illuminate condition based on generated three-dimensional data; And control data generation unit, this control data generation unit is based on set illuminate condition, generate the control data for controlling the driving that the blade of the multi-diaphragm collimator in above-mentioned particle-beam therapeutic apparatus carries out, above-mentioned three-dimensional data generation unit at least utilizes the deflection angle of the deflection angle of the beam centered by above-mentioned 1st axle and the beam centered by above-mentioned 2nd axle, generates above-mentioned three-dimensional data.

Invention effect

According to multi-diaphragm collimator of the present invention, particle-beam therapeutic apparatus and therapy planning device, due to can multi-diaphragm collimator formed through shape time, make the face of the vane plate being formed as profile consistent with the dispersal direction through the particle beam near this face, therefore, by the impact of penumbra, and the higher irradiation field of contrast can not be formed.

Accompanying drawing explanation

Fig. 1 is the figure be described for the structure of the irradiation system of the particle-beam therapeutic apparatus to the multi-diaphragm collimator comprised involved by embodiments of the present invention 1.

Fig. 2 is in order to the structure of the irradiation system of the particle-beam therapeutic apparatus to the multi-diaphragm collimator comprised involved by embodiments of the present invention 1 is described and the side view observed from 2 directions of the central vertical with beam.

Fig. 3 is the figure be described for the beam state of the charged particle beam in the irradiation system to the particle-beam therapeutic apparatus involved by embodiments of the present invention 1.

Fig. 4 is to multi-diaphragm collimator involved by embodiments of the present invention 1 and the structure of vane plate are described and the figure of the full closeding state illustrated.

Fig. 5 is to multi-diaphragm collimator involved by embodiments of the present invention 1 and the structure of vane plate are described and the figure of the state of the irradiation field of the formation reservation shape illustrated.

Fig. 6 is the figure of the example of the beam track while scan represented in particle-beam therapeutic apparatus involved by embodiments of the present invention 2.

Fig. 7 is the figure of other example of the beam track while scan represented in particle-beam therapeutic apparatus involved by embodiments of the present invention 2.

Fig. 8 is the figure be described for the structure of particle-beam therapeutic apparatus and multi-diaphragm collimator involved by embodiments of the present invention 5.

Fig. 9 is the figure for being described the flow process of medical act.

Figure 10 is the block diagram for being described the structure of the therapy planning device involved by embodiments of the present invention 6.

Detailed description of the invention

Embodiment 1.

Below, the structure of the multi-diaphragm collimator involved by embodiments of the present invention 1 and particle-beam therapeutic apparatus is described.Fig. 1 ~ Fig. 5 is the figure for being described the structure of the multi-diaphragm collimator involved by embodiments of the present invention 1 and particle-beam therapeutic apparatus, Fig. 1 is the figure of the structure of the irradiation system representing the particle-beam therapeutic apparatus comprising multi-diaphragm collimator, Fig. 2 is structure in order to represent particle-beam therapeutic apparatus and multi-diaphragm collimator and the figure that the direction vertical from the center (z direction) with the charged particle beam Fig. 1 is observed, Fig. 2 (a) is the side view observed from y direction, and Fig. 2 (b) is the side view observed from x direction.Fig. 3 is the figure that the figure for being described the shape of the beam in the irradiation system of particle-beam exposure apparatus, Fig. 3 (a) represent the overall appearance of beam; Fig. 3 (b) and Fig. 3 (c) are the figure that the direction vertical from the center (z direction) with the charged particle beam Fig. 3 (a) is observed, Fig. 3 (b) is the side view observed from y direction, and Fig. 3 (c) is the side view observed from x direction.In addition, Fig. 4 and Fig. 5 is in order to multi-diaphragm collimator and the figure that is described as the structure of the vane plate of the main composition body of multi-diaphragm collimator and observes from all directions.

As the prerequisite be described in detail to the structure of multi-diaphragm collimator, first, the irradiation system of the particle-beam therapeutic apparatus comprising multi-diaphragm collimator is described.As shown in Figure 1, 2, particle-beam therapeutic apparatus 10 comprises: oscillating electromagnetic ferrum 1 (upstream 1a, downstream 1b), this oscillating electromagnetic ferrum 1 plays the effect of irradiating mouth, by scanning the charged particle beam B of the so-called form of a stroke or a combination of strokes provided by not shown accelerator on circuit orbit, thus expand irradiation field; Ridged filter 2, this ridged filter 2 is for expanding the width of cloth La Gefeng according to the thickness of irradiation object; Range shift unit 3, this range shift unit 3 changes the energy (range) of charged particle beam B for the degree of depth (depth of shine) according to irradiation object; Link stopper collimator (blockcollimator) 4, this block collimator 4, for being limited in prescribed limit by the irradiation field after expansion, carries out unnecessary irradiation to prevent normal tissue; Multi-diaphragm collimator 5, this multi-diaphragm collimator 5 is by multiple vane plate and drive the vane drive mechanism of each vane plate to form, for limiting irradiation field to make it consistent with affected part shape; And thing block 6, the range of this thing block 6 check strap beam of charged particles B is to make it consistent with the depth shape of irradiation object.

Next, the work in the irradiation system by using the irradiation mouth of swing method to be expanded by irradiation field and principle are described.

Charged particle beam B is accelerated by not shown accelerator, and is fed in irradiation system via transmission system, using as the so-called pencilbeam of diameter at several below mm.Oscillating electromagnetic ferrum 1 scans the beam be directed in irradiation system, depicts circuit orbit to make it.Oscillating electromagnetic ferrum 1 is general as shown in Figure, prepares x direction electric magnet 1a and y direction electric magnet 1b, and is configured to the central shaft X that makes 2 electric magnet along charged particle beam B _bbe connected.Herein, in order to make explanation clear, define x direction and y direction.Coordinate system can define according to various standard, and this description defines coordinate system according to following standard.The direction of advance of charged particle beam B is set to the positive direction of z-axis.X-axis and y-axis are the axles orthogonal with z-axis, and x-axis and y-axis mutually orthogonal.Further, xyz coordinate system is right-handed coordinate system.Fig. 1,2 example in, upstream oscillating electromagnetic ferrum 1a scans beam in the x-direction, and downstream oscillating electromagnetic ferrum 1b scans beam in the y-direction.By the scanning of 2 electric magnet 1a, 1b, irradiation field is extended along xy direction (in-plane).

Expand the charged particle beam B after irradiation field by ridged filter 2.Be that leg-of-mutton plate is arranged in mode in face to form ridged filter to make multiple such as bullet or cross section, if such as multiple zonule will be divided in irradiation field, then there is the beam by different-thickness relative to each zonule.In the drawings, in order to easy understand, be recited as cone and arrange as sword mountain.Thus, the width S OBP (Spread-OutBraggPeak) of cloth La Gefeng is extended.That is, by ridged filter 2, also in the z-direction irradiation field is spread.Next, the charged particle beam B after irradiation field is expanded by range shift unit 3.Range shift unit 3 is devices of the energy for changing charged particle beam B.By range shift unit 3, the irradiation field after expansion can be irradiated to the degree of depth in desired body.Next, block collimator 4 is passed through by the beam after range shift unit 3.Block collimator 4 is the metal derbies etc. being provided with through hole PH, the diffusion of restriction irradiation field on in-plane (xy plane).This is because, if limited range of exposures in advance, then can prevent normal tissue from carrying out unnecessary irradiation.

Next, charged particle beam is by multi-diaphragm collimator 5.As described in detail below, multi-diaphragm collimator 5 is for utilizing according to multiple vane plate 5 _lposition and formed through shape PS, irradiation field is constrained to consistent with affected part shape.That is, utilize multi-diaphragm collimator 5, xy direction limits irradiation field and makes it be shaped.In addition, vane plate 5 is at least comprised in multi-diaphragm collimator 5 _l(be vane group 5 as a whole _g) and vane drive mechanism 5 _d.But, if vane drive mechanism 5 _dcan represent the drive track of blade, then the structure of itself is unimportant.In addition, if owing to recording vane drive mechanism 5 with figure _ditself, then can make expression vane plate 5 _lstructure become difficulty, therefore, upper Fig. 1,2 and accompanying drawing below in, in order to be simplified, among multi-diaphragm collimator 5, only by vane plate 5 _lor merge vane plate 5 _lafter the vane plate group 5 that obtains _gpart extract out and record.

Finally, charged particle beam B is by thing block 6.Thing block 6 is the limiters be made up of resin etc., is rendered as the shape of the affected part degree of depth, such as, is formed as the form of end (Distal) shape compensating affected part.Terminal end shape refers to the concaveconvex shape in most deep.Herein, the energy of irradiation field is limited (being shaped in a z-direction), and has the shape identical with terminal end shape.That is, utilize thing block 6, in a z-direction irradiation field limited and make it be shaped.

The effect of the irradiation system of particle-beam therapeutic apparatus is, makes the irradiation field carrying out irradiating be formed as consistent with affected part.As the method, in the particle-beam therapeutic apparatus involved by present embodiment 1, adopt swing method, in this swing method, only utilize oscillating electromagnetic ferrum 1 to expand irradiation field.The example that the method is concrete is " scanned by spiral beam and realize large area and uniform irradiation " such as shown in patent documentation 3, is also referred to as spiral swing method in swing method.In brief, spiral swing method spirally scans to beam the method expanding irradiation field, guarantees flatness by the scan track (track while scan) improved in this irradiation field.In addition, the scan track of the beam formed by spiral swing method can referring to Fig. 1 etc. of patent documentation 3.

On the other hand, swing method generally refers to single circle swing method more, in the case, guarantees flatness when expanding irradiation field by scattering object.Therefore, even if in identical swing method, also have the situation using scattering object and the situation not using scattering object, the directivity of beam is also different because of the presence or absence of scattering object.When using scattering object, because on whole of scattering object, beam spreads, therefore, the direction of illumination of the beam by certain point produces width.On the other hand, as spiral swing method, not using scattering object, and only use scanning electro-magnet to spread beam, in the case, is primarily of leaving the position of scanning electro-magnet and a direction determining by the direction of illumination of beam of certain point.

Fig. 3 represents in the irradiation system of the particle-beam therapeutic apparatus 10 involved by present embodiment 1, diffusion way (the beam F of the beam utilizing two-stage scan electric magnet 1 to produce _bshape) schematic diagram.In spiral swing method, beam spreads as shown in Figure 3, but not the diffusion of point source formula.For convenience of explanation, the diffusion way of the beam shown in Fig. 3 is called " diffusion of two-stage scan formula ".Not point source at beam, and when carrying out the diffusion of two-stage scan formula, need the limiter that design one is suitable mutually therewith.

Here, some detailed description are added to the diffusion of two-stage scan formula.

As shown in Figure 3, beam B from the top to the bottom (z direction) irradiate.Beam B is provided with the thinner state being called pencilbeam originally.At beam axis X _bon, be set with datum mark CPa and datum mark CPb.Datum mark CPa can think that configuration upstream oscillating electromagnetic ferrum 1a (says it is scan axis A scrupulously _sa) position, similarly, datum mark CPb can think configuration downstream oscillating electromagnetic ferrum 1b (say it is scan axis A scrupulously _sb) position.

The upstream oscillating electromagnetic ferrum 1a being configured at datum mark CPa with datum mark CPa for benchmark scans beam.The scanning direction of the beam of upstream oscillating electromagnetic ferrum 1a is that (xz plane) carries out the direction scanned in the plane of Fig. 3 (b), and by beam axis X _bon datum mark CPa, with beam axis X _bvertical axle A _sabecome the effect axle (scan axis) of upstream oscillating electromagnetic ferrum 1a.In addition, the downstream oscillating electromagnetic ferrum 1b being configured at datum mark CPb with datum mark CPb for benchmark scans beam.The scanning direction of the beam of downstream oscillating electromagnetic ferrum 1b is that (yz plane) carries out the direction scanned in the plane of Fig. 3 (c), and by beam axis X _bon datum mark CPb, with beam axis X _band axle A _savertical axle A _sbbecome the effect axle (scan axis) of downstream oscillating electromagnetic ferrum 1b.That is, the scanning direction (y) of the scanning direction (x) of upstream oscillating electromagnetic ferrum 1a and downstream oscillating electromagnetic ferrum 1b and beam axis X _bvertically, and the scanning direction (y) of downstream oscillating electromagnetic ferrum 1b is vertical with the scanning direction (x) of upstream oscillating electromagnetic ferrum 1a.

In addition, utilize Fig. 3 to above-mentioned beam F _bshape carry out geometry explanation.

As shown in Fig. 3 (b), vertical (z direction) line segment that to draw with datum mark CPa be upper extreme point, and the position on line segment except datum mark CPa arranges datum mark CPb.Centered by datum mark CPa, make line segment only rotate ± α degree, now obtain the fan-shaped Fsa that line segment passes through.This fan-shaped Fsa is equivalent to the diffusion of the beam when only using upstream oscillating electromagnetic ferrum 1a.Next, the reference axis A by datum mark CPb is utilized _sbfan-shaped Fsa is divided into the first half and the latter half.Make the latter half of fan-shaped Fsa relative to reference axis A _sbonly rotation ± β degree, now obtains the region that fan-shaped Fsa the latter half is passed through.In Fig. 3 (c), this region can see the region of fan-shaped Fsb as, and this region shows the diffusion way (region that beam energy passes through: beam F of beam _b).That is, the beam F of two-stage scan formula diffusion is carried out _bshape on x direction and y direction, be formed as different fan-shaped of radius of curvature.

Consider and produce to expand irradiation field as described above by 2 scanning electro-magnets 1a, 1b utilizing scanning direction different, beam is carried out to the beam F after the diffusion of two-stage scan formula _bshape, the multi-diaphragm collimator 5 involved by embodiments of the present invention is for correctly forming the higher irradiation field of contrast when not affecting by penumbra.That is, among the multi-diaphragm collimator 5 involved by embodiments of the present invention 1, each vane plate 5 _land the opposite face P of reality with its vane plate adjacent in a thickness direction _lbe formed in a plane, this plane is at the beam axis X of beam of charged particles B _bupper and comprise the scan axis A of the scanning electro-magnet 1a be set on datum mark CPa _sainterior, along to be set in beam axis X _bon datum mark CPb on the scan axis A of scanning electro-magnet 1b _sbcentered by circular orbit, to each vane plate 5 _ldrive, the scan axis A of this scanning electro-magnet 1b _sbwith beam axis X _band scan axis A _savertically.

Below, Fig. 4,5 is utilized to be described in detail.Fig. 4 is that Fig. 4 (a) is the cross-sectional view of the vane group entirety of multi-diaphragm collimator in order to multi-diaphragm collimator being described and carrying out the structure of the vane plate driven and the figure of the state of the blade under the full closeding state illustrated in multi-diaphragm collimator; Fig. 4 (b) is the upper surface perspective view observed from the P direction of Fig. 4 (a), Fig. 4 (c) is the front perspective view observed from the F direction of Fig. 4 (a), and Fig. 4 (d) is the side perspective view of observing the rows of blades of the left-half of multi-diaphragm collimator from the S direction of Fig. 4 (a).In addition, Fig. 5 is the figure of the state representing the irradiation field forming reservation shape, and Fig. 5 (a) is the outside drawing of the vane group entirety of multi-diaphragm collimator; Fig. 5 (b) is the upper surface perspective view observed from the P direction of Fig. 5 (a), Fig. 5 (c) is the front perspective view observed from the F direction of Fig. 5 (a), and Fig. 5 (d) is the side perspective view of observing the rows of blades of the left-half of multi-diaphragm collimator from the S direction of Fig. 5 (a).

As shown in Figure 4,5, multi-diaphragm collimator 5 has multiple vane plate 5 _lan end face E _lalign and arrangement 2 row's rows of blades (5 in a thickness direction _c1, 5 _c2: be collectively referred to as 5 _c), and comprise: vane group 5 _g, this vane group 5 _gbe arranged so that rows of blades 5 _c1with 5 _c2an end face E _ltoward each other; And not shown vane plate driving mechanism, this vane plate driving mechanism drives each vane plate 5 _lwith make its near or away from vane plate corresponding thereto, each vane plate 5 _lshape be the true form of the sheet material interarea as each vane plate, namely with the opposite face P of adjacent vane plate _lbe formed at the scan axis A comprising the scanning electro-magnet 1a expanding charged particle beam B in the x direction _sain interior plane.That is, sheet material interarea is formed at the scan axis A comprising scanning electro-magnet 1a _saon interior 2 planes, the thickness of the cross section cut off vane plate in the plane comprising direction of illumination and thickness of slab direction after along with the upstream side of the direction of illumination from charged particle beam B thickening to downstream.

Further, by each blade 5 _ldrive track (direction in yz plane) be set to circular orbit O _l, this circular orbit O _lwith the scan axis A of distance downstream electrical Magnet 1b _sbdistance corresponding, this downstream electrical Magnet 1b expands charged particle beam B in y-direction, and, at vane plate 5 _l4 end faces in, with an end face E _lthe end face P of adjacent light incident side _ishape and the end face P of emitting side _xshape be formed as respectively with scan axis A _sbcentered by circular arc, that is, by forming a part for annulus centered by scan axis Asb, even if thus circumferentially track O _ldriven vane plate 5 _l, also do not change along the depth dimensions of the direction of illumination of charged particle beam B.

Thus, no matter by vane plate 5 _lbe urged to which position, such as shown in Figure 5, make formation through the vane plate 5 of shape PS profile in the x direction _lend face E _lwith by end face E _lthe direction of illumination of neighbouring charged particle beam B is parallel, thus does not produce penumbra.In addition, make formation through the vane plate 5 of shape PS profile in y-direction _lopposite face P _lwith by opposite face P _lthe direction of illumination of neighbouring charged particle beam B is parallel, thus does not produce penumbra.That is, multi-diaphragm collimator 5 formed through the outline portion of shape PS in do not produce the part of penumbra, can be formed thus and be suitable for affected part shape and correct irradiation field.

That is, as long as each vane plate 5 of the multi-diaphragm collimator 5 involved by embodiments of the present invention 1 _lshape in a thickness direction and drive track O _lwith the beam F of charged particle beam B _bdiffusion shape identical.Be when limiting respectively the scan angle of two-stage scan electric magnet 1a, 1b by scope.Even can be described as beam propagation distance from beam source within the scope of certain time the position of charged particle beam.Because multi-diaphragm collimator 5 is by stacked vane plate 5 _lobtain, therefore, after formation is also the beam F of charged particle beam through shape PS _bdiffusion shape.In addition, thus, the opening (profile) formed through shape PS does not depend on opening shape, make as opening wall, towards vane plate 5 _lthe end face E at irradiation field center _l, and with the opposite face P of adjacent blades plate _l, consistent with by the direction of illumination of the charged particle beam near this face.Therefore, it is possible to solve the penumbra problem caused when using two-stage scan electric magnet 1a, 1b.In addition, when by improve use scattering object to irradiate for the purpose of flatness, in the distribution of the direction of illumination of above-mentioned two-stage scan formula, produce width.Therefore, though when use this multi-diaphragm collimator 5, the charged particle beam of a part also can be irradiated to the end face E of vane plate _lor opposite face P _lon, compared with not using the situation of scattering object, suppress the effect of penumbra to decrease, but compared with existing simple bullet multi-diaphragm collimator, the effect of the penumbra that can be inhibited.

In addition, in the multi-diaphragm collimator 5 involved by above-mentioned embodiment 1, with the position of upstream side electric magnet 1a for benchmark sets the shape of thickness direction, with the position of downstream electric magnet 1b for benchmark sets drive track O _l, but be not limited in this, also can carry out contrary setting.Therefore, upstream electrical Magnet 1a scans x direction, and downstream electrical Magnet 1b scans y direction, but also can be contrary.In addition, show in figure and specify each vane plate 5 _lthe opposite face P of thickness _lbetween angle equal, but be not limited in this.The effect of the above-mentioned penumbra that also can be inhibited even if unequal.And, showing opposite face with " in fact " is because opposite face is in a thickness direction stacked, and be for other face, vane region adjacent in fact, can be regarded as: such as, even if be formed with the ditch or groove etc. for the formation of driving track in opposite face, be also formed at the scan axis A comprising the scanning electro-magnet 1a be set on datum mark CPa _sain interior plane.In addition, rows of blades 5 _c1, 5 _c2each blade 5 _lbe rendered as man-to-man pair state, but also in pairs non-essential.In addition, rows of blades is also non-essential is 2 row, such as, when only there being string, as long as at the end face E of vane plate _lnear beam axis X _btime, be close to stationary plane and stop beam B.In addition, also some row can be had.

In addition, as the method expanding irradiation field, the spiral spiral swing method of track while scan is illustrated, but as illustrated in embodiment described later, also can adopts other spiral swing method, and be not limited only to spiral swing method.In addition, work the electric magnet irradiating mouth function and be also not limited in oscillating electromagnetic ferrum 1, as long as utilize scanning direction different 2 electric magnet are to expand the irradiation mouth of irradiation field.

As mentioned above, multi-diaphragm collimator 5 according to the present embodiment involved by 1, this multi-diaphragm collimator be configured at for utilize scanning electro-magnet 1 to after expanding irradiation field illuminated go out charged particle beam B in, for the formation of the irradiation field being suitable for irradiation object and affected part shape, and this multi-diaphragm collimator 5 comprises: rows of blades 5 _c, this rows of blades 5 _cmake multiple vane plate 5 _lan end face E _lalign and make it arrange in a thickness direction; And vane plate driving mechanism 5 _d, this vane plate driving mechanism 5 _ddrive each vane plate 5 _l, to make an end face E _lrelative to the beam axis X of particle beam B _b, relative to vane plate corresponding thereto near or away from, each vane plate 5 _lamong, vane plate and the opposite face P at the upper vane plate adjacent with this vane plate of thickness direction (x direction) _lbe formed in plane P _saon, plane P _sacomprise the 1st axle and scan axis A _sa, the 1st axle is set in the beam axis X of charged particle beam B _bon the 1st position and datum mark CPa and with beam axis X _bvertically, vane plate driving mechanism 5 _dalong with the 2nd axle and scan axis A _sbcentered by circular orbit O _lcarry out driven vane plate 5 _l, the 2nd axle is set in beam axis X _bon the 2nd position and datum mark CPb and with beam axis X _band the 1st axle A _savertically, because multi-diaphragm collimator 5 has such structure, therefore, the opposite face P of the profile through shape PS of multi-diaphragm collimator 5 is formed _lor end face E _ldirection and the beam F of charged particle beam B _bdiffusion way consistent, thus the impact of penumbra can be suppressed and form correct irradiation field according to the shape of irradiation object.

In addition, due at vane plate 5 _lin 4 main end faces, will with an end face E _ladjacent surface and the end face P of light incident side of charged particle beam B _iand the end face P of emitting side _xshape be formed as centered by the 2nd axle and scan axis Asb circular arc, therefore, it is possible to be easy to circumferentially track O _lcarry out driven vane plate 5 _l.In addition, in any case driven vane plate 5 _l, also do not change along the depth dimensions of the direction of illumination of charged particle beam B, thus make the distance for masking tape beam of charged particles constant.

In addition, particle-beam therapeutic apparatus 10 involved by embodiments of the present invention 1 comprises: oscillating electromagnetic ferrum 1, and 2 electric magnet 1a, 1b that this oscillating electromagnetic ferrum 1 utilizes scanning direction different scan the charged particle beam B provided by accelerator and irradiate to expand irradiation field; And above-mentioned multi-diaphragm collimator 5, this multi-diaphragm collimator 5 is configured at charged particle beam B (the i.e. beam F irradiated by irradiation mouth 1 _b) in, the scan axis (A of an electric magnet in the 1st axle of multi-diaphragm collimator 5 and above-mentioned 2 electric magnet _saor A _sb) consistent, and the scan axis (A of the 2nd axle and another electric magnet _sbor A _sa) consistent, according to such structure, the impact of penumbra can be suppressed and utilize the irradiation field corresponding to the shape of irradiation object to irradiate charged particle rays.

Embodiment 2.

In embodiment 1, set forth the application of the spiral swing method of beam being carried out to helical form scanning.But the scan track shape (track while scan) of beam in irradiation field is not limited in technological thought of the present invention, and in other beam track while scan, the situation of carrying out the diffusion of two-stage scan formula also can give play to effect.Therefore, in present embodiment 2, multi-diaphragm collimator of the present invention is applied in the irradiation system with other representational beam track while scan, this situation is set forth.

First, to utilizing the spiral swing method used in embodiment 1, the beam track while scan obtained is described.As recorded in patent documentation 3, helical form track while scan obtains according to the formula (1) comprising following 3 equatioies.

(mathematical expression 1)

$\begin{array}{c}r\left(t\right)=\sqrt{\frac{R_{\max }-R_{\min }}{\mathrm{\π}N}{v}_{0}t+R_{\min }^2}\\ \mathrm{\ω}\left(t\right)=\frac{v_0}{\sqrt{\frac{R_{\max }-R_{\min }}{\mathrm{\π}N}{v}_{0}t+R_{\min }^2}}\\ \stackrel{\·}{\·\·}\mathrm{\θ}\left(t\right)=\mathrm{\θ}\left(\text{0}\right)\text{+}{\∫}_{\text{0}}^t\mathrm{\ω}\left(\mathrm{\τ}\right)d\mathrm{\τ}\end{array}...\left(1\right)$

Wherein, radius during time t=0 is set to R _min, radius during time t=T is set to R _max, scanning times is set to N.In addition, r (t) is the coordinate of radial direction; θ (t) is the coordinate of angle direction, is namely represented by polar coordinate system.

In the shape of a spiral, this shape is to scan beam in border circular areas and obtaining the valid shape of uniform dose distribution to the beam track while scan obtained according to above-mentioned formula (1).But, in order to obtain uniform dose distribution, helical form will be defined as by beam track while scan.Can think that the beam track while scan obtaining uniform dose distribution for the scanning by 2 electric magnet can be categorized into several typical pattern.

Swing method is the method routinely scanning to be formed uniform dose distribution to beam.That is, the beam track while scan be preferably in swing method is continuous and has periodically.Therefore, to utilizing polar coordinate system to represent beam trajectory, and make r (t) and θ (t) carry out continuous and periodically variable pattern to discuss.

< typical case pattern 1>

In the first pattern, r (t) and θ (t) is as follows, is all defined as and carries out continuous and periodically variable function.

R (t)=continuously and there is periodic function (cycle is T ₁)

θ (t)=continuously and there is periodic function (cycle is T ₂),

In addition, r (t) now can use different value with the cycle of θ (t).In addition, note angle θ, 360 degree can be considered rotate a circle after obtain 0 degree.That is, 360 degree is continuous print with 0 degree.If represented with radian, then 2 π can regard as 0.

As the example realizing above-mentioned pattern, the beam track while scan shown in formula (2) comprising 3 equatioies below can be listed.

r(τ)＝r ₁+r ₂sin(ω _rτ+φ _r)

θ(τ)＝ω _θτ···(2)

τ＝τ(t)

Wherein τ (t) is by the parameter of the above-mentioned formula (2) of parametric representation, is the function of time.ω _rbe the angular velocity determining r (t), the cycle of r (t) is 2 π/ω _r.φ _rit is initial phase.ω _θbe the angular velocity determining θ (t), the cycle of θ (t) is 2 π/ω _θ.

As shown in Figure 6, the example of the beam track while scan ST1 that through type (2) generates is shown.Fig. 6 is the figure representing the track while scan be in certain plane vertical with beam axis, and transverse axis is x, and the longitudinal axis is that y, x and y are respectively through standardization.In addition, in formula (2), parameter not being set to time t is to change depicting speed according to different situations.Such as, in figure 6, with coordinate (0,0) be beam axis central part, because near beam axis central part, beam scanning is comparatively concentrated and density is higher, therefore, picture near central part part the concentrated part of track, manage, by scanning speed quickening etc., to obtain uniform dose distribution thus.

< typical case pattern 2>

In the second pattern, combine to form beam track while scan to the function of multiple definition depicting pattern.Such as, the function of larger circle and the combination of function describing less circle will be described.The formula (3) comprising 3 equatioies below shows one of them example.

x(τ)＝r ₁cos(ω ₁τ+φ ₁)+r ₂cos(ω ₂τ+φ ₂)

y(τ)＝r ₁sin(ω ₁τ+φ ₁)+r ₂sin(ω ₂τ+φ ₂)···(3)

τ＝τ(t)

Wherein, x (τ) is respectively x coordinate, the y coordinate of beam track while scan, is orthogonal coordinate system.The example of the beam track while scan generated by mathematical expression (3) has been shown in Fig. 7.Fig. 7 and Fig. 6 is the same, and be all the figure representing the track while scan be in certain plane vertical with beam axis, transverse axis is x, and the longitudinal axis is that y, x and y are respectively through standardization.

A kind of stage property is had in toy, therein be formed with the disk that gear-like is set in toothed circular port, and insert nib being arranged in the aperture on the assigned position in disk, make disk rotate along circular port thus depict geometry pattern, the geometry pattern be made up of this stage property also belongs to this classification.In addition, the curve depicted by this stage property is called as length width hypocycloid (hypotrochoid), carrying out as given a definition to this curve geometrically, namely when being that the circle of r is as movable circle, using the centre distance round apart from this activity point that is Ir as when fixing a point with radius, the mode of the circumference inscribe that the circle being r to make radius and radius are kr, does not rotate relative to the circumference that this radius is r the track obtained by making this activity circle slidably.In addition, in most agitating device, this pattern is used for the driving pattern of mixing part.In addition, the same with example above, parameter is not set to time t, its reason is, in order to make it possible to difference according to circumstances to change depicting speed.

As mentioned above, utilizing oscillating electromagnetic ferrum to describe continuously and having in the method for periodic pattern (line chart), this pattern is not limited to helical form.But do not use scattering object and realize large area by design beam trajectory and uniform idea of irradiating comes from " spiral swing method ", therefore, these methods shown in embodiment 2 are also referred to as the spiral swing method of broad sense.Further, in the spiral swing method of these broad sense, the diffusion way of beam is not point source formula yet, but two-stage scan formula.

That is, present embodiment 2 have use broad sense spiral swing method irradiation system particle-beam therapeutic apparatus in, apply multi-diaphragm collimator shown in embodiment 1, therefore, it is possible to make each vane plate shape in a thickness direction and drive track, beam F with charged particle beam B _bdiffusion shape identical.Therefore, what formed is also the beam F of charged particle beam B through shape PS _bdiffusion shape, the peristome formed through shape PS does not depend on opening shape, but make as its wall, towards the end face at the irradiation field center of vane plate and the opposite face with adjacent blades plate, consistent with the direction of illumination of charged particle beam.Therefore, it is possible to solve the penumbra problem caused when using two-stage scan electric magnet.

Embodiment 3.

In above-mentioned embodiment 1 and 2, the situation adopting swing method to irradiate is set forth.But as mentioned above, illuminating method itself is not substantial portion of the present invention, also can not to technological thought of the present invention and indefinite.In particle-beam therapeutic apparatus, propose a kind of spot scan method, this scanning method utilizes two-stage scan electric magnet to scan charged particle beam, and carries out an irradiation to irradiation object in a description mode.When spot scan, the diffusion way of beam is also two-stage scan formula.Therefore, when using multi-diaphragm collimator in spot scan, also can give play to and suppress above-mentioned penumbra and the effect forming the higher irradiation field of contrast.

Embodiment 4.

In embodiment 3, set forth the situation to the multi-diaphragm collimator point of application scanning method involved by embodiments of the present invention.The same with spot scan method, also have raster scanning method, this raster scanning method utilizes two-stage scan electric magnet to scan beam, and carries out grating irradiation to irradiation object in single stroke (one-strokewriting) mode.When carrying out raster scanning, the diffusion way of beam is also two-stage scan formula.Therefore, when using multi-diaphragm collimator in raster scanning, the multi-diaphragm collimator 5 involved by above-mentioned embodiment of the present invention can give play to effect.That is, when expanding irradiation field by the scanning method such as spot scan or raster scanning, if use the multi-diaphragm collimator 5 involved by embodiments of the present invention, then can give play to and suppress above-mentioned penumbra and the effect forming the higher irradiation field of contrast.

Embodiment 5.

In particle-beam therapeutic apparatus, such as, as described in patent documentation 4, propose following scheme: namely by the control method of design deflection electric magnet, thus omit in two scanning electro-magnets.But, due in such irradiation system, deflection electric magnet for changing orbital direction (direction of beam axis) scans charged particle beam, to replace the scanning electro-magnet be omitted, therefore, beam also carries out the diffusion of two-stage scan formula, thus makes the multi-diaphragm collimator in above-mentioned embodiment give play to the effect suppressing penumbra.

Fig. 8 represents the figure of the multi-diaphragm collimator in the particle-beam therapeutic apparatus possessing embodiment 5 in interior irradiation system part.In the drawings, for the charged particle beam B provided from horizontal direction (x direction), utilize deflection electric magnet 201a that beam axis is deflected to vertical direction, after passing through scanning electro-magnet 201b, the same with embodiment 1, via ridged filter 2, range shift unit 3, annular collimator 4, multi-diaphragm collimator 205 and agglomerate 6, be irradiated to irradiation object.Further, particle-beam therapeutic apparatus in present embodiment 5 210 is with the difference of embodiment 1 structure: arrange and deflect electric magnet 201a, in alternate embodiments 1 particle-beam therapeutic apparatus 10 in scanning electro-magnet 1a; And the setting benchmark of the shape of the vane plate of multi-diaphragm collimator 205 and track is different.

In the drawings, the beam axis P of the charged particle beam B provided from horizontal direction _xin the inside of deflection electric magnet 201a while depict circular arc as, deflect to z direction.Now, usually when using deflection electric magnet, carry out controlling to make magnetic field constant, therefore, the beam of charged particle beam B does not spread, but, when using this deflection electric magnet 21, this deflection electric magnet 21 by periodic variation magnetic field, thus can scan to make beam in x direction from P to charged particle beam B in x direction _e1diffuse to P _e2.That is, the effect that electric magnet 201a plays the upstream scanning electro-magnet 1a in embodiment 1 is deflected.Part afterwards and embodiment are substantially identical, and scanning electro-magnet 201b makes the beam carrying out in x direction spreading spread to y direction again.

The diffusion way of this beam can regard as the equivalent datum mark E at Fig. 8 _ason have the scan axis of upstream scanning electro-magnet 201a, along beam axis E _xthe beam (comprising z direction composition) be irradiated into from top scans, in the x direction in the x direction from E _e1be diffused into E _e2.In addition, in deflection electric magnet 201a, along with the advance of beam, beam axis deflects gradually, therefore, and the beam axis of entrance side and the beam axis (=beam axis E of outlet side _x) different, scan axis E _aSbe positioned at the position left outside deflection electric magnet 201a main body.But, because the beam axis incided in multi-diaphragm collimator 205 is beam axis E _x, therefore, regulation scan axis E can be interpreted as _aSthe datum mark CPa of position be on the beam axis of the beam incided in multi-diaphragm collimator 205, scan axis E can also be interpreted as _aSvertical with the beam axis of the beam incided in multi-diaphragm collimator 205.Therefore, in the irradiation system as described above an electric magnet being also used as deflection electric magnet, also to incide the beam axis of the beam in multi-diaphragm collimator as benchmark, equivalent scan axis E can be calculated according to the diffusion way of beam _as, and the same with embodiment 1, utilize equivalent scan axis E _asand scan axis A _sb(datum mark CPb) sets shape and the track of the vane plate of multi-diaphragm collimator 205.

As shown in Figure 8, this irradiation system eliminates a scanning electro-magnet, and make the deflection electric magnet 201a of curved in tracks carry out alternative institute elliptical scanning electro-magnet, in the case, special electric magnet is scanned (such as with use, 1a, 1b of embodiment 1) the common irradiation system that carries out scanning compares, and specifies equivalent scan axis E _asthe datum mark CPa of (equivalence) and the interval of datum mark CPb become large.Therefore, carry out in the multi-diaphragm collimator of beam blow-up mode of point source formula in supposition, the problem producing penumbra seems particularly remarkable.But, what kind of no matter forms through shape, all to make formation through the face of the shape profile mode identical with the direction of the diffusion of beam, set shape and the track of each vane plate of the multi-diaphragm collimator 205 involved by embodiments of the present invention 5.Therefore, it is possible to easily solve the comparatively outstanding penumbra problem produced in the irradiation system eliminating single scanning electro-magnet.

As mentioned above, in the particle-beam therapeutic apparatus 210 involved by present embodiment 5, when 2 directions x, y are scanned, utilize deflection electric magnet 201a that the direction of beam axis is deflected to one of them (x or y) to scan, and the beam axis of setting datum mark CPa, CPb is set to the beam axis E of the beam incided in multi-diaphragm collimator 205 _x, carry out formation and the configuration of multi-diaphragm collimator 205, therefore, it is possible to suppress penumbra and form the higher irradiation field of contrast.

Embodiment 6.

In each embodiment 1 ~ 5 above-mentioned, to multi-diaphragm collimator and employ the structure of irradiation system of multi-diaphragm collimator, its beam trajectory is illustrated.In present embodiment 6, the therapy planning device of the working condition of the multi-diaphragm collimator involved by setting each embodiment above-mentioned of the present invention, particle-beam therapeutic apparatus is described.

Here, before therapy planning device is described, the prerequisite of the treatment plan that therapy planning device is implemented and physician practice are described.Generally can think that physician practice was made up of several stage.Fig. 9 shows the stage (flow process) of this physician practice, and shows the device used in each stage.Based on Fig. 9, treatment flow process is described.

Specifically, can say that physician practice is roughly made up of each stage following: prediction diagnosis stage (MS1), diagnostic phases (MS2), treatment plan stage (MS3), treatment stage (MS4) and rehabilitation later observation stage (MS5).Further, especially when carrying out particle-beam therapeutic etc., the device used in each stage above-mentioned is the device shown on the right side of Fig. 9.Such as, the device used in diagnostic phases (MS2) is X-ray filming apparatus, CT (ComputedTomography: computerized tomograph), MRI (MagneticResonanceImaging: nuclear magnetic resonance image) etc., and the device used in the treatment plan stage (MS3) is the device being called as therapy planning device.Further, the device used in treatment stage (MS4) is radiation treatment device or particle-beam therapeutic apparatus.

Next, each stage is described.

The prediction diagnosis stage (MS1) refers to does not depend on that whether morbidity carries out the stage of prediction diagnosis.Such as, periodic physical examination or physical examination etc. all belong to this, for cancer, there will be a known: utilize the method for the fluoroscopy images of X-ray etc., the method for the tomography such as (PositronEmissionTomography: Positron Emission Computed Tomography), PET/CT that utilizes PET and utilize the method etc. of gene test (immune detection).

The stage carrying out diagnosing premised on treating is carried out after diagnostic phases (MS2) refers to morbidity.When carrying out particle-beam therapeutic, in order to treat, need to obtain the position of affected part, the three-dimensional information of shape.Therefore, various CT, the MRI device that can obtain the three-dimensional data of affected part is used.

The treatment plan stage, (MS3) referred to the stage setting treatment plan based on above-mentioned diagnostic result.When carrying out particle-beam therapeutic, utilize the therapy planning device involved by present embodiment 6 to make treatment plan in this stage.To carry out later the detailed description of therapy planning device, and next continue to be described remaining stage.

Treatment stage (MS4) refers to that the result based on above-mentioned treatment plan carries out the stage of actual treatment.When carrying out particle-beam therapeutic, use particle-beam therapeutic apparatus in this step.Multi-diaphragm collimator involved by each embodiment above-mentioned of the present invention is used for forming irradiation field in the irradiation system of particle-beam therapeutic apparatus.In addition, in treatment stage, also there is the situation of carrying out once irradiating therapeutic progresses and just terminating, but usually need repeatedly to irradiate in during certain section.

As literal meaning, rehabilitation later observation step (MS5) refers to carries out rehabilitation or to whether recurring the stage of carrying out later observation.When cancer, the later observation of carrying out in this stage is the same with the prediction diagnosis stage, adopts with the following method: utilize the method for the fluoroscopy images such as X-ray, utilize the method for the tomographies such as PET, PET/CT and utilize the method etc. of gene test (immune detection).

In physician practice as above, treatment plan is a series of operation carried out after diagnostic phases, before treatment stage.Due in particle ray diagnosing and treating apparatus, the treatment plan of trying to achieve according to utilizing therapy planning device, illumination bands beam of charged particles, therefore, the therapy planning device in particle-beam therapeutic roughly comprises the unit with following effect.

Effect A: the unit being generated three-dimensional data by the image information of the multiple irradiation objects got in advance.

Effect B: the unit generating best illuminate condition (treatment plan scheme) based on given condition.

Effect C: the distribution of final dosage is simulated and the unit shown it for optimum results (treatment plan scheme).

That is, therapy planning device plays the effect of illuminate condition accepted needed for diagnostic result setting treatment, and this therapy planning device has and plays based on set condition, the unit generating the effect D of the control data of particle-beam therapeutic apparatus etc.

In order to function as described above, therapy planning device also specifically has following function.

< effect A >

Function a: the function being generated three-dimensional data by the tomography image obtained in diagnostic phases.

Function b: the function showing generated three-dimensional data as three-dimensional CAD from each visual angle.

Function c: distinguish affected part and normal structure and the function that it is stored in generated three-dimensional data.

< effect B >

Function d: the parameter of the particle-beam therapeutic apparatus used in therapeutic progresses is set and simulates the function of irradiating.

Function e: under the condition set by the user of this device, contrast and penetrate the function be optimized.

< effect C >

Function f: with the mode coincided with above-mentioned three-dimensional data, the function that shows the irradiation result after being optimized.

< effect D >

Function g: the function setting the shape of multi-diaphragm collimator and thing block in order to the irradiation after realizing above-mentioned optimization.(comprising many mouthfuls of irradiations when hypothesis broad-beam condition irradiates)

Function h: the function setting the irradiation track of beam in order to the irradiation after realizing above-mentioned optimization.(supposing to scan the situation of irradiating)

Function i: for realizing the irradiation track of above-mentioned beam and generating the function of driving code of particle-beam therapeutic apparatus.

Other > of <

Function j: the function storing the various data generated in the apparatus.

Function k: by reading various data in store in the past, the function of information in the past can be recycled.

The system structure of the therapy planning device for realizing each function above-mentioned is described.In recent years, the manufacturer of therapy planning device designs hardly and manufactures intrinsic hardware, and greatly mainly with based on the Unix that market is sold (registered trade mark) operating platform or PC, and its peripheral equipment also uses common apparatus mostly.That is, the manufacturer of therapy planning device is absorbed in exploitation to therapy plot software, manufacture selling.In therapy plot software, as the subprogram recalled by mastery routine, prepare the module of each function of such as practical function a ~ function k.For the flow process in function a ~ function k, or to omit or change condition performs again as required, the user of therapy planning device can formulate treatment plan while recalling necessary module thus.

Next, each function or the module that realizes each function are described, the therapy planning device involved by embodiments of the present invention is described.

(module a) generates three-dimensional data by a series of tomography images obtained in diagnostic phases to function a.When reading tomography image, also can read according to the patient informations such as patient ID, scanning information (slice spacings, slice thickness, FOV, tomography condition etc.).Here, three-dimensional data refers in therapy planning device with virtual and the mode of three-dimensional reappears the necessary information of the reference object comprising affected part.Generally speaking, adopt following method: the Virtual Space in definition therapy planning device, in above-mentioned Virtual Space at equal intervals and carry out collocation point in the mode of lattice-shaped, and make the material information obtained from tomography image correspond to this point.This function is that the reason of necessary function is, one of most important object of therapy planning device is simulation treatment, maintains, and needs to reappear the affected part and the perienchyma thereof that become irradiation object.

Function b (module b) shows the three-dimensional data of generation from each visual angle as three-dimensional CAD.

Function c (module c) can in generated three-dimensional data, distinguishes affected part and normal structure and stores.Such as, suppose that tomography image utilizes X ray CT and obtains.In this case, " material information " that use in function a is equivalent to the complexity of X-ray transparent.That is, the threedimensional model reappeared in Virtual Space based on this tomography image is the shape of the three-dimensional body be made up of the material that the degree of X-ray transparent is different.For this " material information " i.e. complexity of X-ray transparent, in the Virtual Space of therapy planning device, by Change Example as color or brightness represent.In addition, based on this " material information ", can until following information: namely, in the threedimensional model reappeared in Virtual Space, this part is equivalent to bone portion, or this part is equivalent to the part of tumor, and can distinguish affected part and normal structure.The result distinguishing affected part and normal structure can be stored in the storage device (hard disk etc.) of therapy planning device.

Function d (module d) is set in the parameter of the particle-beam therapeutic apparatus used in treatment stage, and simulation is irradiated.The parameter of so-called particle-beam therapeutic apparatus refers to the geometry information of particle-beam therapeutic apparatus, the information relevant to irradiation field.Geometry information such as to comprise at center, the platform position etc. of sleeping.The information relevant to irradiation field comprises above-mentioned " coordinate of datum mark CPa and datum mark CPb " etc.In addition, the vane plate 5 of multi-diaphragm collimator 5 or 205 (hereinafter only recording 5 representatively) is also comprised _lwidth (thickness), vane plate 5 _lquantity and vane plate 5 _lthe parameter such as displacement (angle).

Function e (module e) based on this therapy planning device user set by condition, contrast is penetrated and is optimized.

Function f (module f) is in the mode coincided with above-mentioned three-dimensional data, carrys out the irradiation result after display optimization.

Function g (module g) sets the shape of multi-diaphragm collimator 5 and thing block 6 in order to the irradiation after realizing above-mentioned optimization.Function when this function is the irradiation of hypothesis broad-beam condition, comprises the situation of leafy irradiation.

Function h (module h) is the irradiation track setting beam in order to the irradiation after realizing above-mentioned optimization.This function is the function that hypothesis carries out when spot scan or raster scanning etc. scan.

Function i (module i) is in order to realize the irradiation track of above-mentioned beam and generate the driving code of particle-beam therapeutic apparatus.Now, as described below, according to the coordinate system of answering with two-stage scan formula diffusion couple, each multi-diaphragm collimator 5 shown in embodiment 1 ~ 5 above-mentioned then can be made easily to generate and drive code, this driving code is for realizing the opening shape (through shape SP) corresponding with tried to achieve the best irradiation plan.

Function j (module j) stores the various data setting in the apparatus and generate.

Function k (module k), by reading various data in store in the past, can utilize information in the past thus again.

The coordinate system > that < and two-stage scan formula diffusion couple are answered

In existing therapy planning device, for the three-dimensional data used in above-mentioned functions a and function afterwards, generally represent with orthogonal coordinate system (xyz coordinate system).When the global shape of multi-diaphragm collimator is existing cuboid, because the driving direction of its configuration or blade is also by orthogonal coordinates direction (such as, x direction or y direction) represent, therefore, orthogonal coordinate system can be utilized to represent three-dimensional data.Its reason is, makes the shape data and the vane drive data consistent that generate peristome shape according to affected part shape.

On the other hand, due to when using involved in the present invention multi-diaphragm collimator 5, vane plate 5 _ldriving curved, be therefore preferably, the command value being used in driven vane is the angle centered by datum mark.That is, be preferably, be used in the shape data generating peristome shape with affected part shape accordingly and comprise with the identic of vane drive command value of the present invention and angle centered by datum mark.

Therefore, the therapy planning device involved by embodiments of the present invention 6 utilizes special coordinate system to show the three-dimensional data of affected part.

Specifically, as the special coordinates system shown in (D1) of giving a definition.

[ψ _a，ψ _b，r _b]·····(D1)

Wherein, ψ _athe deflection angle of the beam centered by reference axis (Asa), this reference axis (Asa) and beam axis X _bvertical and by datum mark CPa, ψ _bthe deflection angle of the beam centered by reference axis (Asb), this reference axis (Asb) and beam axis X _band reference axis Asa is vertical and by datum mark CPb, r _bfrom datum mark CPb (or reference axis (the Asb)) distance to this point of irradiation.

Arbitrfary point in three dimensions uniquely can both be represented by above-mentioned 3 information.Wherein, need to carry out predefined datum mark CPa and datum mark CPb according to the configuration of scanning electro-magnet 1a, 1b.In addition, beam also can be used to propagate into the distance r till this point of irradiation from datum mark CPa (or reference axis (Asa)) _adeng, to replace rb.

Here, to irradiate the initial point of benchmark Ji Deng center as xyz coordinate system, to the hypothesis that datum mark CPa and datum mark CPb xyz coordinate separately carries out as follows.

Datum mark CPa:(0,0 ,-l _a)

Datum mark CPb:(0,0 ,-l _b)

Further, as shown in Figures 1 to 3, upstream scanning electro-magnet 1a is assumed to be x scanning direction electric magnet, downstream scanning electro-magnet 1b is assumed to be y scanning direction electric magnet.Now, the coordinate of certain point is by [the ψ by special coordinates system represented by of definition shown in (D1) _a, ψ _b, r _b] and obtain, now, the xyz coordinate of this point is represented by following formula (4) respectively.

(mathematical expression 2)

Here, if the Rot as (D2) in definition (4) _x(ψ _b) and Rot _y(ψ _a), then the xyz coordinate of certain point is obtained like that such as formula (5).

(mathematical expression 3)

On the contrary, the method for special coordinates system is obtained by xyz coordinate system as follows.

Due to l _bbe the intrinsic value of irradiation system, therefore, it is possible to such such as formula (6), the relation of y and the z in through type (5) obtains ψ _b.

(mathematical expression 4)

In addition, due to l _aalso be the intrinsic value of irradiation system, therefore, can also as definition (D3), the relation of y and the z in through type (5) defines,

Λ：＝y ²+(z+l _b) ²+(l _a－l _b)···(D3)

＝(l _a―l _b+r _b)cosψ _a

The relation of the z in through type (5) and definition (D3), utilize formula (7) to obtain ψ _a.

(mathematical expression 5)

Finally, formula (8) can be utilized to obtain r _b.

(mathematical expression 6)

$\begin{array}{c}{x}^2+{\mathrm{\&Lambda;}}^2={(l_a-l_b+r_b)}^2\\ \stackrel{\&CenterDot;}{\&CenterDot;\&CenterDot;}{r}_b=\sqrt{x^2+{\mathrm{\&Lambda;}}^2}-(l_a-l_b)\end{array}...\left(8\right)$

Coordinate system [the ψ corresponding with the beam blow-up of above-mentioned two-stage scan formula is brought into use from the stage of function a _a, ψ _b, r _b].That is, in function a, or as being used for the miscellaneous function of n-back test a, have the ordinate transform function to the conversion of special coordinates system, this ordinate transform function performs when hypothesis carries out two-stage scan.

Such as, Figure 10 utilizes block diagram to represent the figure of the effect (unit) of the therapy planning device involved by embodiments of the present invention 6, the characteristic of function (module).In the drawings, therapy planning device 20 comprises: three-dimensional data generation unit 21, and this three-dimensional data generation unit 21 generates three-dimensional data according to the view data of the affected part as irradiation object; Illuminate condition setup unit 22, this illuminate condition setup unit 22 sets illuminate condition based on generated three-dimensional data; And control data generation unit 23, this control data generation unit 23 generates the control data of particle-beam therapeutic apparatus based on set illuminate condition.In addition, as mentioned above, because these unit, module utilize software to be formed in computer, therefore, not shownly this part is physically formed.

Further, three-dimensional data generation unit 21 comprises: three-dimensional data generation module 21 _m1, this three-dimensional data generation module 21 _m1generate the three-dimensional data of affected part or build etc. according to view data as function a; Coordinate transferring 21 _m2, this coordinate transferring 21 _m2generated three-dimensional data is converted to the coordinate system [ψ shown in definition (D1) _a, ψ _b, r _b] data, this definition (D1) when suppose carry out two-stage scan set up; Display data generation module 21 _m3, this display data generation module 21 _m3display data are generated, using as function b based on the data after conversion; And irradiation object separation module 21 _m4, this irradiation object separation module 21 _m4distinguish affected part as irradiation object and normal structure based on the data after conversion, and three-dimensional data generation unit 21 forms the three-dimensional data produced according to the coordinate system shown in definition (D1) according to image information, using as effect A.

Further, illuminate condition generation unit 22, based on the three-dimensional data that produces according to the coordinate system shown in definition (D1), utilizes function d, e to set best illuminate condition, using as effect B.Further, control data generation unit 23 comprises: through shape setting module 23 _m1, should through shape setting module 23 _m1based on set illuminate condition set by multi-diaphragm collimator 5 formed through shape PS, using as function g; And drive code generation module 23 _m2, this driving code generation module 23 _m2based on the set driving code generating each blade 5L of multi-diaphragm collimator 5 through shape, using as function i, and, control data generation unit 23 is based on set illuminate condition, the control data of multi-diaphragm collimator 5 is at least generated, using as effect D by the coordinate system shown in definition (D1).

Thus, in three-dimensional data generation unit 21 or illuminate condition setup unit 22, that at least use the deflection angle of the deflection angle of the beam centered by reference axis (Asa) and the beam centered by reference axis (Asb) to be given for determine irradiation position and the three-dimensional data of the coordinate system of definition shown in (D1), wherein, this reference axis (Asa) and beam axis X _bvertical and by datum mark CPa, this reference axis (Asb) and beam axis X _band reference axis Asa is vertical and by datum mark CPb.Therefore, the driving code of multi-diaphragm collimator 5 generated in control data generation unit 23 is the driving codes for realizing opening shape (through shape SP), this opening shape and the best calculated by illuminate condition setup unit 22 irradiate plan corresponding.That is, in the therapy planning device 20 involved by embodiments of the present invention 6, among the function (module) of the effect for realizing treatment plan, there is the function to the conversion of special coordinates system, and utilize this special coordinates system to carry out regulation three-dimensional data, wherein, this special coordinates system uses when supposing to carry out two-stage scan.Therefore, for generating the shape data of peristome shape and vane drive command value accordingly with affected part shape, all by comprising the identical form of the angle centered by datum mark, (this angle is used in rows of blades 5 _cmiddle selection has the opposite face P close to this angle _lvane plate 5 _l) represent.Therefore, it is possible to carry out at beam in the irradiation system of two-stage scan formula diffusion, be easy to generate and optimally-controlled driving code is carried out to multi-diaphragm collimator 5.

Therefore, in the therapy planning device 20 involved by embodiments of the present invention 6, for employing the particle-beam therapeutic apparatus that can suppress to carry out the above-mentioned multi-diaphragm collimator 5,205 of the penumbra produced in the irradiation system of two-stage scan formula diffusion at particle beam, in order to form the shape of peristome in the mode corresponding with affected part shape, directly can utilize the three-dimensional data being exported by therapy planning device 20 or input to therapy planning device 20, generate the drive command value of blade.

As implied above, the therapy planning device 20 according to the present embodiment involved by 6, comprising: three-dimensional data generation unit 21, and this three-dimensional data generation unit 21 generates three-dimensional data according to the view data of irradiation object and affected part; Illuminate condition setup unit 22, this illuminate condition setup unit 22 sets illuminate condition based on generated three-dimensional data; And control data generation unit 23, this control data generation unit 23 is based on set illuminate condition, at least generate the control data of the multi-diaphragm collimator 5 involved by above-mentioned embodiment 1 to 5 in the control data of particle-beam therapeutic apparatus, because three-dimensional data generation unit 21 utilizes by the deflection angle ψ of the beam centered by reference axis Asa _a, beam centered by reference axis (Asb) deflection angle ψ _b, and distance r and the coordinate system specified to generate above-mentioned three-dimensional data, therefore, in order to form the shape of peristome in the mode corresponding with affected part shape, directly can utilize the three-dimensional data inputting to therapy planning device 20 or exported by therapy planning device 20, generate the drive command value of this blade, wherein, this reference axis Asa and beam axis X _bvertical and by datum mark CPa; This reference axis (Asb) and reference axis Asa and beam axis X _bvertical and by datum mark CPb; This distance r is the distance leaving reference axis Asa or Asb or datum mark CPa or CPb.That is, in control data generation unit 23, due to 2 deflection angle ψ can be utilized _aand ψ _bspecify above-mentioned control data, therefore, this particle-beam therapeutic apparatus can carry out suppressing penumbra in the irradiation system of two-stage scan formula diffusion at particle beam, and utilize contrast higher and the beam of high-quality irradiates, for particle-beam therapeutic apparatus, the higher and irradiation that precision is higher of contrast can be carried out.

Label declaration

1: oscillating electromagnetic ferrum (1a:x direction (upstream) scanning electro-magnet; 1b:y direction (downstream) scanning electro-magnet)

2: ridged filter

3: range shift unit

4: annular collimator

5: multi-diaphragm collimator (5 _l: vane plate; 5 _g: vane group; 5 _d: vane drive portion)

6: thing block

10: particle-beam therapeutic apparatus

20: therapy planning device

21: three-dimensional data generation unit

22: illuminate condition setup unit

23: control data generation unit

Asa: scan axis (the 1st the axle) (E of upstream scanning electro-magnet _as: assuming that axle)

Asb: the scan axis (the 2nd axle) of downstream scanning electro-magnet

CPa: the 1 datum mark

CPb: the 2 datum mark

E _l: an end face relative with vane plate

F _b: the beam (diffusion) of particle beam

OL: the drive track of vane plate

P _i: vane plate is (with E _ladjacent) the end face of side, beam incident face

P _l: the opposite face of the thickness direction of vane plate

PS: through shape

P _x: vane plate is (with E _ladjacent) the end face of beam outgoing plane side

ST: the track while scan of particle beam

X _b: the beam axis (E of particle beam _x: the beam axis inciding the beam of multi-diaphragm collimator)

The variation involved by numeral embodiment of hundred.

Claims (4)

1. a particle-beam therapeutic apparatus, is characterized in that, comprising:

Irradiate mouth, 2 electric magnet that this irradiation mouth utilizes scanning direction different scan the particle beam provided by accelerator, and irradiate; And

Multi-diaphragm collimator, this multi-diaphragm collimator is configured in the path of the particle beam irradiated by described irradiation mouth, and has: rows of blades, and this rows of blades arranges in a thickness direction to make the mode of multiple vane plate end face alignment; And vane plate driving mechanism, this vane plate driving mechanism is to make the mode of a described end face or beam axis away from described particle beam close to the beam axis of described particle beam, drive multiple described vane plate respectively, and described multi-diaphragm collimator limits or is formed the irradiation field of described charged particle beam in the mode be consistent with the shape of irradiation object

Described irradiation mouth utilizes scanning method to irradiate described particle beam.

2. particle-beam therapeutic apparatus as claimed in claim 1, it is characterized in that, by vane plate described in each and with the opposite face of its vane plate adjacent be in a thickness direction formed at comprise the 1st axle plane on, 1st axle is set in the 1st position on described beam axis, and it is vertical with this beam axis

Described vane plate driving mechanism along the distance with the 2nd axle be certain track to drive described vane plate, the 2nd axle is set in the 2nd position described beam axis leaving described 1st position predetermined distance, and vertical with this beam axis and described 1st axle.

3. particle-beam therapeutic apparatus as claimed in claim 2, is characterized in that, multiple described vane plate described end face be separately positioned at comprise described 2nd axle plane on.

4. particle-beam therapeutic apparatus as claimed in claim 2, is characterized in that, utilize described vane plate driving mechanism to drive, with in the plane making multiple described vane plate described end face separately be positioned to comprise described 2nd axle.