CN105251138B - A kind of particle-irradiation device and the particle therapy system including the device - Google Patents
A kind of particle-irradiation device and the particle therapy system including the device Download PDFInfo
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- CN105251138B CN105251138B CN201510778390.XA CN201510778390A CN105251138B CN 105251138 B CN105251138 B CN 105251138B CN 201510778390 A CN201510778390 A CN 201510778390A CN 105251138 B CN105251138 B CN 105251138B
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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Abstract
The present invention relates to a kind of particle-irradiation device, including：The particle beam transmitted along central axis, including second particle beams and the 3rd particle beams；Collimater in the transmission path of the 3rd particle beams, the 3rd particle beams form the Two dimensional Distribution completely the same according to wild shape corresponding with tumor target by collimater；The planarizer having around the rotatable block piece of central axis in the transmission path of second particle beams；Block piece planarizes second particle beams to form the 3rd particle beams.The present invention also provides a kind of particle therapy system for including particle-irradiation device.The present invention realizes that the homogenization of dosage is distributed by planarizer, it is only necessary to which simple block piece can obtain desired particle-irradiation device and the particle therapy system including device, so as to improve the reliability of irradiation unit and treatment system, while reduce cost.
Description
Technical field
The present invention relates to a kind of device and system using radiation cure cancer, relate more specifically to a kind of particle-irradiation
Device and the particle therapy system including the device.
Background technology
Particle radiotherapy is one of current anti-cancer therapies state-of-the-art in the world.(X ray is put with common photon radiotherapy
Treat) compare, when particle is irradiated in patient body, maximum dose peak value will be formed in particle range terminal, i.e. formed so-called
Bragg peak (Bragg Peak)., can be by high agent thus by precision control particle beam energy and particle beam irradiation position
Particle cover is measured in target tumor target area, while by the unfavorable of the normal structure around target tumor and normal organ
Exposure dose is reduced at least, so as to realize the dosage distribution more conformal than X ray radiotherapy, improves the therapeutic effect of tumour,
Reduce side effect.
Generally, particle accelerator 1, PARTICLE TRANSPORT FROM device 2, particle are included using the particle therapy system of two-dimentional illuminating method
Irradiation unit 3, irradiation control device 4 and patient positioning unit, as shown in figure 1, wherein, the particle beams caused by particle accelerator 1
Usual beam spot size is flowed for less than 10 millimeters, thus is swollen when need the particle beams being evenly radiated into such as a diameter of 10 centimetres
During knurl target area 5, then need that the particle beams of the beam spot diameter, only less than 1 centimetre is expanded into 10 centimetres of models using particle-irradiation device 3
Enclose.Specifically, the initiating particle beam 11 for coming from particle accelerator 1 is carried into particle-irradiation dress by PARTICLE TRANSPORT FROM device 2
Put 3, undulator 31 makes the 11 planned track scanning of initiating particle beam, formed have fixation locus (such as it is circular or
The tracks such as ZigZag shapes) first particle beams 32, first particle beams 32 by scattering object 33 scatter after form second particle beams
34, the particle beams 32 of second particle beams 34 to the first has the bigger angle of divergence, and second particle beams 34 is removed by collimater 35
Unnecessary particle is removed, it is final to irradiate tumor target 5.Wherein, the undulator 31 is mainly used in making initiating particle beam 11 based on
The track scanning drawn, so that the particle for eventually arriving at tumor target 5 is uniformly distributed in the plane.Clearly as wave magnetic
The use of iron 31 and respective drive power supply, the structure of existing particle therapy system is often more complicated, and cost is higher.
The content of the invention
In order to solve, the particle therapy system of two-dimentional illuminating method existing for above-mentioned prior art is complicated and cost is high
The problem of, the present invention is intended to provide a kind of particle-irradiation device and the particle therapy system including the device.
The present invention provides a kind of particle-irradiation device, including：The particle beam transmitted along central axis, it includes second
The particle beams and the 3rd particle beams；Collimater in the transmission path of the 3rd particle beams, the 3rd particle beams pass through collimation
Device forms the Two dimensional Distribution completely the same according to wild shape corresponding with tumor target；In the transmission path of second particle beams
Planarizer, the planarizer include surround the rotatable block piece of central axis；Second particle beams passes through planarization
The 3rd particle beams is formed after device.By the planarization, in the plane perpendicular to central axis, the 3rd particle beams is than second
The particle beams has the particle density distribution being more uniformly distributed.
Be that radius r locates with the vertical range of central axis, the radian acr-angle (r) of the block piece for 360 degree and
Gear goes ratio attenuation (r) product, wherein, it is the grain that part gear falls that is blocked that the gear, which removes ratio attenuation (r),
Subnumber and the ratio for the population being distributed in whole circumference.
Planarization range is formed in radius r radial extension, along the direction away from central axis, the radian of block piece
Angle acr-angle (r) is gradually reduced in planarization range.
The planarizer also includes revolving part and fixture, and revolving part is to be rotatably supported at admittedly around central axis
Determine the circular ring part on part, the end of the remote central axis of block piece is fixedly connected on the inner ring of the circular ring part.
The end of the neighbouring central axis of block piece is formed as free end.
The planarizer also includes actuator and driving member, and actuator is connected with revolving part by driving member.
The revolving part engages with the driving member.
The driving member is belt.
The particle beam also includes first particle beams, and the particle-irradiation device also includes the transmission installed in first particle beams
Scattering object on path, first particle beams after scattering volume scattering by forming second particle beams, and second particle beams is than first
Beamlet has the bigger angle of divergence.
The particle-irradiation device also includes the monitoring in the transmission path of first particle beams or second particle beams
Device.
The present invention also provides a kind of particle therapy system, including above-mentioned particle-irradiation device.
The particle therapy system also includes particle accelerator and PARTICLE TRANSPORT FROM device, and particle accelerator provides initiating particle
Beam, it is carried into particle-irradiation device by PARTICLE TRANSPORT FROM device.
The particle therapy system also includes existing for adjusting particle beam in the transmission path of the 3rd particle beams
The ridge filter of the dosage distribution in tumor depth direction.
The particle therapy system also include installed in the 3rd particle beams transmission path on be used for stop particle beam
Range compensator in the most deep position of the tumor target of corresponding irradiation position.
The present invention realizes that the homogenization of dosage is distributed by planarizer, eliminates undulator and its driving power
Use, it is only necessary to which simple block piece can obtain desired particle-irradiation device and the particle therapy system including the device
System, so as to improve the reliability of irradiation unit and treatment system, while reduces cost.
Brief description of the drawings
Fig. 1 is the schematic diagram according to the particle therapy system of prior art；
Fig. 2 is the schematic diagram according to the particle therapy system of the first embodiment of the present invention；
Fig. 3 is the revolving part of Fig. 2 particle therapy system and the perspective view of block piece；
Fig. 4 is the schematic diagram of Fig. 3 block piece being in particle beam；
The block piece being in particle beam that Fig. 5 is Fig. 3 blocks principle schematic；
Fig. 6 is the curve synoptic diagram of the particle beam of block piece upstream；
Fig. 7 is the curve synoptic diagram of the particle beam in block piece downstream；
Fig. 8 is the curve synoptic diagram of the particle beam in collimater downstream；
Fig. 9 is the revolving part of particle therapy system according to the second embodiment of the present invention and the perspective view of block piece；
Figure 10 is the perspective view of the planarizer of particle therapy system according to the third embodiment of the invention.
Embodiment
Below in conjunction with the accompanying drawings, presently preferred embodiments of the present invention is provided, and is described in detail.
Embodiment 1
Fig. 2 is the schematic diagram of particle therapy system according to the first advantageous embodiment of the invention, the particle therapy system
Including particle accelerator 10, PARTICLE TRANSPORT FROM device 20, particle-irradiation device 30, irradiation control device 40 and patient positioning unit,
Tumor target 50 is positioned on the patient positioning unit.Particle accelerator 10, PARTICLE TRANSPORT FROM device 20 and particle-irradiation device 30
Connected respectively with the irradiation communication of control device 40, to be controlled to particle beam.The center of particle-irradiation device 30 and tumour
The center of target area 50 is on the central axis 110a of particle beam.
In order to describe conveniently, the particle beam can artificially divide into initiating particle beam 110, first particle beams 320, second
The particle beams 370 of beamlet 340 and the 3rd.Wherein, initiating particle beam 110 comes from particle accelerator 10, and it is filled by PARTICLE TRANSPORT FROM
Put 20 and be carried into particle-irradiation device 30, form first particle beams 320；First particle beams 320 is scattered by scattering object 330
After form second particle beams 340, the particle beams 320 of second particle beams 340 to the first has the bigger angle of divergence；Second particle
Beam 340 has by forming the 3rd particle beams 370, the particle beams 340 of the 3rd particle beams 370 to the second after planarizer 360
The particle density more uniformly spread in the plane；3rd particle beams 370 removes unnecessary particle by collimater 350,
Final irradiation tumor target 50.
Along the direction of illumination (hereinafter referred to as axial) of particle beam, planarizer 360 is arranged on second particle beams
In 340 transmission path.In the present embodiment, the planarizer 360 is arranged at the downstream of scattering object 330, and is arranged at
The upstream of collimater 350.The present invention is by the particle beams 340 of planarizer 360 second corresponding to tumor target 50
Plane domain perpendicular to axial direction is (hereinafter referred to as horizontal) with the distribution of uniform dosage, of the prior art so as to eliminate
Undulator 31, homogenization is realized simple in constructionly, significantly reduce the cost of particle therapy system.
The planarizer 360 includes actuator 361, driving member 362, revolving part 363, fixture 364 and block piece
365.Revolving part 363 is to be formed as revolving part around the rotatable circular ring parts of central axis 110a, i.e. central axis 110a
363 pivot.Block piece 365 is fixedly connected on the inner ring of the revolving part 363, so that block piece 365 follows rotation
Turn part 363 to rotate around central axis 110a.Bearing 366 is provided with the outer ring of revolving part 363, so that the revolving part
363 are supported on fixture 364 by bearing 366.Actuator 361 is motor, and it passes through the phase of driving member 362 with revolving part 363
Even, so as to drive revolving part 363 to rotate by motor.
Fig. 3 is the revolving part 363 of the planarizer 360 of the present embodiment and the perspective view of block piece 365, wherein, block
The remote central axis 110a of part 365 one end is formed as connection end 365a, and the other end is formed as free end 365b, the block piece
365 are welded in by connection end 365a on the inner ring of revolving part 363.It should be understood that connection end 365a can also for example pass through
The mode being adhesively fixed is connected on the inner ring of revolving part 363.Except connection end 365a, block piece 365 and without other branch
Support structure, so that particle beam will not be blocked by other supporting constructions, i.e. the overall profile of block piece 365 is configured to
The part uniquely blocked to particle beam (i.e. second particle beams 340), as shown in Figure 4.The block piece 365 can be formed
The material such as polymethyl methacrylate (PMMA) Polymer material of lucite or aluminum or aluminum alloy.This is blocked
Part 365 has thickness d vertically, as long as the thickness can effectively block the transmission of particle beam, thickness it is specific
Numerical value depends on range of the particle beams in block piece 365.For example, the proton beam energies that ought be used for treatment of cancer are 230MeV,
And block piece 365, when being lucite, thickness d is more than about 33cm；When the proton beam energies for treatment of cancer are
70MeV, and when block piece 365 is lucite, thickness d is more than about 4cm；When the proton beam energies for treatment of cancer are
230MeV, and when block piece 365 is aluminium, thickness d is more than 16cm.
As shown in figure 4, block piece 365 is in second particle beams 340 of intimate Gaussian Profile F1 (r), i.e. central area
Particle density it is big, and the example density of peripheral region is small.Fig. 5 is that block piece blocks principle schematic, perpendicular to center
It is the center of circle with central axis 110 in axis 110a plane, r is that radius picture is justified, the corresponding circular arc of the formation on block piece 365
It is referred to as block piece 365 (r), for the block piece 365 (r) at certain Radius r, by the population that gear falls and whole circle
The ratio for the population being distributed on week is referred to as gear and removes ratio attenuation (r), and it is equal to the radian of the block piece 365 (r)
Angle arc-angle (r) and 360 degree of ratio.In order to realize the purpose of homogenization, such as when near r=0, block piece 365
(0) radian arc-angle (0)=180 degree so that the particle near the central axis 110a of particle beam is kept off one
Half；And as r increase, acr-angle (r) are tapered into.In this way, along the direction away from central axis 110a, block piece
The acr-angle (r) of 365 (r) is tapered into planarization range, the ratio that the particle of second particle beams 340 is kept off with
Taper into, so as to be intended to homogenize.
The process of the homogenization as Figure 6-Figure 7, wherein, Fig. 6 is particle beam (i.e. the second particle of block piece upstream
Beam 340) curve synoptic diagram, and Fig. 7 is the curve synoptic diagram of the particle beam (i.e. the 3rd particle beams 370) in block piece downstream.
In order to describe conveniently, Gaussian Profile F1 (r) is artificially divided into the central area Q1 and peripheral region Q2 around central area,
It should be understood that what the border between central area Q1 and peripheral region Q2 was not to determine, as long as ensuring to eventually arrive at tumor target
All particles beams in area 50 are both from central area Q1.The setting purpose of block piece 365 is to weaken central area Q1's
Particle density (region of the block piece 365 in the Q1 of central area is planarization range), it is close to peripheral region Q2 grain
Sub- density, so as to realize F1 (r) planarization, obtain the F2 (r) shown in Fig. 7.It should be understood that the distance center of block piece 365
Outer rim farthest axis 110a can be defined by the border between central area Q1 and peripheral region Q2, now, be blocked
Part 365 only weakens central area Q1 particle density, along the direction away from central axis 110a, the radian of block piece 365
Acr-angle (r) is gradually reduced；But outer rim farthest the distance center axis 110a of block piece 365 can also exceed center
Border between region Q1 and peripheral region Q2, now, block piece 365 not only weaken central area Q1 particle density, simultaneously
Also weakened part peripheral region Q2 particle density, along the direction away from central axis 110a, the radian of block piece 365
Acr-angle (r) is gradually reduced in planarization range.
The total time for irradiating tumor target 50 is T0, and the requirement of planarization is realized within this T0 time, due to block piece
365 are blocked, and some particles in particle beam gear of part 365 that is blocked is gone, after irradiation time T0, and in the absence of block piece
365 particle beam cross direction profiles F1 (r) compares, planarization distribution F2 (r)=attenuation (r) * F1 (r).In order to true
The effect of the planarization of second particle beams 340 is protected, total revolution N of the block piece 365 in time T0 is chosen to be sufficiently large, and its is specific
The speed of rotation depends on distribution error.If it is required that the error of distribution is brought to be less than because block piece 365 is in diverse location
1%, then total revolution N just at least needs more much larger than 100.When total revolution N is 100, then because block piece 365 is in not
The error come with band of position is about 1% degree.Preferably, in actual irradiation time T0, the corotating 500 of block piece 365
Turning, then one turn of error only represents the 1/500 of accumulated dose, at the time of irradiation time T0 when last turns, block piece 365
Distribution error can is ignored caused by the angle stopped.Now, distribution error meets clinical needs below 2%.Separately
Outside, in order to ensure second particle beams 340 planarization effect, the radius r of block piece 365 gradient depends on distribution precision.
Such as it can select as requested as 0.1mm, 1mm or 2mm.Preferably, the radius r of block piece 365 gradient is no more than center
The 1/10 of region Q1 radius r.
Fig. 2 is returned to, collimater (Patient Collimator) 350 can be multi-leaf optical grating collimater (MLC：Multi-
Leaf-collimator), for the 3rd particle beams 370 after planarization process to be confined into tumor target 50.It should manage
Solution, the collimater can also be the photograph provided with metal backup of adequate thickness etc. according to treatment plan wild shape plane hole machined and
Into patient's collimater (Patient Collimator).Specifically, the two-dimensional shapes provided are calculated according to treatment plan to make
Collimater leaves behind the particle required for irradiation tumor target 50, formed by standard to remove the particle of unwanted cross direction profiles
The irradiation field shape that the shape of straight device determines, that is, ultimately form the two dimension completely the same according to wild shape corresponding with tumor target 50
Cross direction profiles F3 (r), as shown in Figure 8.
In order to be monitored to particle beam, particle-irradiation device 30 of the invention also includes monitor 380, such as Fig. 2
It is shown.In the present embodiment, the monitor 380 is arranged in the transmission path of second particle beams 340, that is, is arranged at scattering object
330 downstream.In another embodiment, the monitor 380 can be also arranged in the transmission path of first particle beams 320, that is, is set
It is placed in the upstream of scattering object 330.The monitor 380 is used for the physical quantity related to the particle beams for monitoring particle beam, such as logical
The dosage for the particle beams often said.In addition, the monitor 380 is additionally operable to monitor the position of the particle beams, to ensure in particle beam
Mandrel line 110a is substantially the pivot of block piece 365, and both do not have big deviation.
In order to apply the particle beam of different-energy in particle-irradiation device 30, by only wide several millimeters of cloth of script
Glug peak expands to the suitable width of the depth of tumor target 50 vertically, and particle-irradiation device 30 of the invention also includes ridge
Type filter (Ridge Filter).The ridge filter is arranged in the transmission path of the 3rd particle beams 370, for adjusting grain
Dosage of the beamlet stream in tumor depth direction is distributed, so as to form the dosage of uniform three-dimensional conformal in the tumor target 50 of three-dimensional
Distribution,
In order to which the range of each particle beam of the different lateral attitudes to being irradiated to tumor target 50 is adjusted, the present invention
Particle-irradiation device 30 also include range compensator (Range Compensator).The range compensator is arranged on the 3rd
In the transmission path of the particle beams 370 so that particle beam can stop to should irradiation position tumor target 50 it is most deep
Position, so as to realize the suitable type of tumour bottom.
In the present embodiment, the particle is proton.It should be understood that the invention is not limited in using proton beam.Due to matter
Beamlet is the most commonly used particle of particle radiotherapy circle, therefore proton beam unrestricted, other particles beams only as example herein, very
The present invention, such as carbon ion beam are equally applicable to photon.
Embodiment 2
Same as Example 1, particle therapy system according to the second embodiment of the present invention includes particle accelerator, particle
Feeding device, particle-irradiation device, irradiation control device and patient positioning unit, tumor target positioning and the patient positioning unit
On.As shown in figure 9, particle-irradiation device includes planarizer 360 ', the planarizer 360 ' include revolving part 363 ' and
Block piece 365 '.Part same as Example 1 will not be repeated here, as different from Example 1, the outer ring of revolving part 363 '
For gear structure, so as to driving member meshed transmission gear.In addition, according to the requirement of planarization, the shape of the block piece 365 '
It is slightly different with embodiment 1.
Embodiment 3
Same as Example 1, particle therapy system according to the third embodiment of the invention includes particle accelerator, particle
Feeding device, particle-irradiation device, irradiation control device and patient positioning unit, tumor target positioning and the patient positioning unit
On.As shown in Figure 10, particle-irradiation device includes planarizer 360 ", and the planarizer 360 " includes actuator 361 ",
Driving member 362 ", revolving part 363 " and block piece 365 ".Part same as Example 1 will not be repeated here, with embodiment 1 not
With, driving member 362 " is belt so that actuator 361 " by means of the belt drive revolving part 363 " rotation.In addition,
According to the requirement of planarization, shape and the embodiment 1 of the block piece 365 " are slightly different, but same as Example 2.
Although in addition, it is to be appreciated that include for particle beam spot to be expanded into a diameter of several lis in above-described embodiment
The scattering object of rice, but the scattering object is dispensed, because the initiating particle beam for coming from particle accelerator inherently has
There is certain angle of divergence, as long as apart from enough, equally can realize the requirement of planarization by means of the spirit of the present invention.And
And although the cross direction profiles of second particle beams 340 in above-described embodiment are shown as Gaussian Profile F1 (r), the Gauss point
Cloth is used only as example and unrestricted, and in the case of non-gaussian distribution, the cross direction profiles of second particle beams 340 can not directly pass through
Curve obtains, and can now be realized by measuring, the final requirement for realizing planarization.
Above-described, only presently preferred embodiments of the present invention is not limited to the scope of the present invention, of the invention is upper
Stating embodiment can also make a variety of changes, such as can also be connected and fixed between planarizer and revolving part using box and pin,
Revolving part can also realize rotation etc. by other any kinds of drive of mechanically or electrically moving.I.e. every right according to the present patent application
Simple, the equivalent changes and modifications that claim and description are made, fall within the claim protection model of patent of the present invention
Enclose.The not detailed description of the present invention is routine techniques content.
Claims (12)
1. a kind of particle-irradiation device, including：
The particle beam transmitted along central axis (110a), it includes second particle beams (340) and the 3rd particle beams (370)；
Collimater (350) in the transmission path of the 3rd particle beams (370), the 3rd particle beams (370) pass through collimation
Device (350) forms the Two dimensional Distribution completely the same according to wild shape corresponding with tumor target (50)；
Characterized in that,
Planarizer (360) in the transmission path of second particle beams (340), the planarizer (360) include
Around central axis (110a) rotatable block piece (365), the block piece (365) is flat by second particle beams (340)
Smoothization forms the 3rd particle beams (370)；
It is being that the radian acr-angle (r) of the block piece (365) is at radius r with the vertical range of central axis (110a)
360 degree of products that ratio attenuation (r) is removed with gear, wherein, it is the part that is blocked that the gear, which removes ratio attenuation (r),
(365) ratio for the population being distributed in the population and whole circumference that gear falls；
Planarization range is formed in radius r radial extension, along the direction away from central axis (110a), block piece
(365) radian acr-angle (r) is gradually reduced in planarization range.
2. particle-irradiation device according to claim 1, it is characterised in that the planarizer (360) also includes rotation
Part (363) and fixture (364), revolving part (363) are to be rotatably supported at fixture (364) around central axis (110a)
On circular ring part, the end of the remote central axis (110a) of block piece (365) is fixedly connected on the circular ring part
On inner ring.
3. particle-irradiation device according to claim 2, it is characterised in that the neighbouring central axis of block piece (365)
The end of (110a) is formed as free end.
4. particle-irradiation device according to claim 2, it is characterised in that the planarizer (360) also includes driving
Part (361) and driving member (362), actuator (361) are connected with revolving part (363) by driving member (362).
5. particle-irradiation device according to claim 4, it is characterised in that the revolving part engages with the driving member.
6. particle-irradiation device according to claim 4, it is characterised in that the driving member is belt.
7. particle-irradiation device according to claim 1, it is characterised in that the particle beam also includes first particle beams
(320), the particle-irradiation device also include installed in first particle beams (320) transmission path on scattering object (330), first
The particle beams (320) forms second particle beams (340) after being scattered by scattering object (330), second particle beams (340) ratio first
Beamlet (320) has the bigger angle of divergence.
8. particle-irradiation device according to claim 7, it is characterised in that the particle-irradiation device, which also includes, to be arranged on
Monitor (380) in the transmission path of first particle beams (320) or second particle beams (340).
9. a kind of particle therapy system, it is characterised in that the particle therapy system is included according to any one of claim 1-8 institutes
The particle-irradiation device stated.
10. particle therapy system according to claim 9, it is characterised in that the particle therapy system also adds including particle
Fast device (10) and PARTICLE TRANSPORT FROM device (20), particle accelerator (10) provide initiating particle beam (110), and it is filled by PARTICLE TRANSPORT FROM
Put (20) and be carried into particle-irradiation device.
11. particle therapy system according to claim 9, it is characterised in that the particle therapy system also includes being arranged on
The ridge mistake for being used to adjust dosage of the particle beam in tumor depth direction and being distributed in the transmission path of 3rd particle beams (370)
Filter.
12. particle therapy system according to claim 9, it is characterised in that the particle therapy system also includes being arranged on
The tumor target (50) for being used to make particle beam stop at corresponding irradiation position in the transmission path of 3rd particle beams (370)
The range compensator of most deep position.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510778390.XA CN105251138B (en) | 2015-11-13 | 2015-11-13 | A kind of particle-irradiation device and the particle therapy system including the device |
| PCT/CN2016/072760 WO2017080118A1 (en) | 2015-11-13 | 2016-01-29 | Particle irradiation device and particle therapy system comprising device |
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|---|---|---|---|
| CN201510778390.XA CN105251138B (en) | 2015-11-13 | 2015-11-13 | A kind of particle-irradiation device and the particle therapy system including the device |
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| CN105251138B true CN105251138B (en) | 2018-03-13 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251138B (en) * | 2015-11-13 | 2018-03-13 | 上海艾普强粒子设备有限公司 | A kind of particle-irradiation device and the particle therapy system including the device |
| CN105797282B (en) * | 2016-03-07 | 2018-09-04 | 上海艾普强粒子设备有限公司 | A kind of particle-irradiation device and the particle therapy system including the device |
| CN106110523B (en) * | 2016-08-18 | 2019-04-26 | 上海艾普强粒子设备有限公司 | A kind of particle-irradiation device and the particle therapy system including the device |
| CN109260606A (en) * | 2017-07-17 | 2019-01-25 | 住友重机械工业株式会社 | Charged particle beam treatment system |
| CN108671417A (en) * | 2018-03-27 | 2018-10-19 | 中科超精（安徽）科技有限公司 | Pencil beam Response characteristics based on self-consistency |
| CN109011213A (en) * | 2018-08-17 | 2018-12-18 | 江苏莱福医疗器械科技有限公司 | A kind of radioactive particle automatic sequencing device |
| CN112083467B (en) * | 2020-09-28 | 2022-05-31 | 中国科学院近代物理研究所 | Three-dimensional dose measurement detection system of particle therapy device |
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| EP3569289B1 (en) * | 2010-02-24 | 2020-12-09 | Accuray, Inc. | Gantry image guided radiotherapy system and related target tracking methods |
| JP5095037B2 (en) * | 2010-07-15 | 2012-12-12 | 三菱電機株式会社 | Particle beam irradiation apparatus and particle beam therapy apparatus provided with the same |
| US9839793B2 (en) * | 2013-06-06 | 2017-12-12 | Mitsubishi Electric Corporation | Particle therapy device and method for setting dose calibration factor |
| CN105251138B (en) * | 2015-11-13 | 2018-03-13 | 上海艾普强粒子设备有限公司 | A kind of particle-irradiation device and the particle therapy system including the device |
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| CN103068441A (en) * | 2010-08-17 | 2013-04-24 | 三菱电机株式会社 | Multilear collimator, particle beam therapy device and therapy planning device |
| CN104941077A (en) * | 2010-08-17 | 2015-09-30 | 三菱电机株式会社 | Multi-blade collimator, particle ray treatment device and a treatment planning device |
| CN103200993A (en) * | 2011-03-10 | 2013-07-10 | 三菱电机株式会社 | Particle therapy device |
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