CN104941077B - Multi-diaphragm collimator, particle-beam therapeutic apparatus and therapy planning device - Google Patents

Abstract

It is an object of the invention to obtain a kind of influence from penumbra and be capable of the multi-diaphragm collimator and particle-beam therapeutic apparatus of the higher irradiation field of degree of being contrasted.The multi-diaphragm collimator includes：Rows of blades (5_C), the rows of blades (5_C) by multiple vane plates (5_L) an end face (E_L) align and make its arrangement in a thickness direction；And vane plate driving mechanism (5_D), the vane plate driving mechanism (5_D) so that an end face (E_L) compared with beam axis (X_B) closer or far from mode drive each vane plate (5_L), for each vane plate (5_L), it vane plate and is formed at the opposite face (PL) of the vane plate adjacent vane plate in a thickness direction including beam axis (X_B) on the 1st axis (A_sa) including plane (P_Sa) in, vane plate driving mechanism (5_D) along with beam axis (X_B) on the 2nd axis (A_sb) centered on circular orbit (O_L) carry out driving blade plate (5_L), the 2nd axis (A_sb) and beam axis (X_B) and the 1st axis (A_sa) vertical.

Description

Multi-diaphragm collimator, particle-beam therapeutic apparatus and therapy planning device

The present patent application is international application no for PCT/JP2010/063874, and international filing date is August in 2010 17 days, Into the Application No. 201080068421.8 of National Phase in China, it is entitled " multi-diaphragm collimator, particle-beam therapeutic apparatus with And therapy planning device " application for a patent for invention divisional application.

Technical field

Particle-beam therapeutic apparatus and the definite grain the present invention relates to multi-diaphragm collimator, using the multi-diaphragm collimator The therapy planning device of the operating condition of sub- beam therapeutic apparatus, the multi-diaphragm collimator are suitable for using the grain of charged particle beam Irradiation field is formed in sub- beam therapeutic apparatus.

Background technology

Particle-beam therapeutic be it is a kind of by by charged particle beam irradiation to the affected part for being used as treatment object with to affected part group It knits to give and destroys the therapy treated, in order not to which perienchyma is made to be damaged, and it is enough to give affected tissue Dosage, it is desirable to be able to the particle-beam therapeutic suitably controlled (hereinafter, referred to irradiation field) exposure dose, range of exposures Device.It is among particle-beam therapeutic apparatus, use the so-called wide of the irradiation mouth including scanning electro-magnets such as oscillating electromagnetic iron In the irradiation type particle-beam therapeutic apparatus of domain, expand irradiation field using mouth is irradiated, and configuration makes in the irradiation field after expansion Through the multi-diaphragm collimator that shape changes, so as to be formed and the corresponding irradiation field of affected part shape.

By multi-diaphragm collimator be arranged so that 2 be listed in be laminated on thickness direction vane plate rows of blades it is opposite, and lead to It crosses so that each vane plate to be made closer or far from a manner of to drive the vane plate to opposite vane plate, it is predetermined so as to be formed Through shape.Therefore, it is possible to control by the physical location to each vane plate, it is readily able to form irradiation field.But In the case of linear drives being carried out to vane plate, the outline portion at separate irradiation field center, with dispersal direction at an angle Charged particle beam irradiation in a part for vane plate end face, causing the dosage of charged particle beam that continuity attenuation occurs, i.e., Generate so-called half shadow bands.Thus, it is contemplated that the diffusion of beam proposes a kind of so-called bullet multi-diaphragm collimator, the taper Body multi-diaphragm collimator is driven blade with circuit orbit, the blade-shaped become be split with the side of circular arc or cone and Into shape (for example, referring to patent document 1 or 2).

Prior art literature

Patent document

Patent document 1：Japanese Patent Laid-Open No. Sho 60-063500 publications (upper right of page 2, bottom right~3rd page of page 2 left side Upper, Fig. 2, Fig. 4)

Patent document 2：Japanese Patent Laid-Open No. Sho 63-225199 publications (bottom right~4th page upper right of page 3, the left side of page 7 Under~bottom right, Fig. 1~Fig. 3, Figure 12~Figure 13)

Patent document 3：Japanese Patent Laid-Open 10-255707 publications (paragraph 0009~0020, Fig. 1, Fig. 5)

Patent document 4：Japanese Patent Laid-Open 2006-166947 publications (paragraph 0015~0016, Fig. 1)

The content of the invention

Problem to be solved by the invention

However, for above-mentioned bullet multi-diaphragm collimator, it is assumed that use the beam formed by point light source diffusion.In other words It is, in the case of it is assumed that using volume source, without considering the situation for making diffusion way different due to direction is different.The opposing party Face, in order to expand irradiation field in the particle ray device for using charged particle beam, it is necessary to right as shown in patent document 3,4 The electromagnet that the relatively narrow beam provided by accelerator is scanned.Moreover, because, it is necessary to picture in the plane vertical with beam axis X directions electromagnet and y directions electromagnet are such, are respectively arranged at the electromagnet in 2 directions, therefore, in x directions and in y side The starting point being diffused upwards becomes different.Therefore, even if applying above-mentioned multi-diaphragm collimator in particle-beam therapeutic apparatus, There are the following problems for meeting, i.e. the transmission shape of the diffusion way of beam and multi-diaphragm collimator is inconsistent, thus generates penumbra.

The present invention was completed to solve the above problem, its object is to obtain a kind of influence from penumbra and It is capable of the multi-diaphragm collimator and particle-beam therapeutic apparatus of the higher irradiation field of degree of being contrasted.

The means used to solve the problem

The present invention multi-diaphragm collimator configure in the particle beams irradiated to expand irradiation field, and with irradiation The mode that object is consistent forms above-mentioned irradiation field, which includes：Rows of blades, the rows of blades is so that multiple blades The mode of the end face alignment of plate arranges in a thickness direction；And vane plate driving mechanism, the vane plate driving mechanism with Make beam axis from said one end face to the above-mentioned particle beams closer or far from the beam axis of the above-mentioned particle beams mode, to drive respectively Multiple above-mentioned vane plates are moved, which is characterized in that, each above-mentioned vane plate and adjacent in a thickness direction with it The opposite face of vane plate be formed in the plane including the 1st axis, the 1st axis is set in the 1st on above-mentioned beam axis Position and vertical with the beam axis, above-mentioned vane plate driving mechanism is above-mentioned to drive along the circular orbit centered on the 2nd axis Vane plate, the 2nd axis are set in the 2nd position on above-mentioned beam axis and vertical with the beam axis and above-mentioned 1st axis.

In addition, the particle-beam therapeutic apparatus of the present invention includes：Mouth is irradiated, which utilizes different 2 in scanning direction A electromagnet is scanned the particle beams provided by accelerator, and is irradiated to expand irradiation field；And above-mentioned leafy standard Straight device, the multi-diaphragm collimator are configured in the particle beams irradiated by above-mentioned irradiation mouth, the feature of the particle-beam therapeutic apparatus Be so that above-mentioned 1st axis is consistent with the scan axis of an electromagnet in above-mentioned 2 electromagnet, and make above-mentioned 2nd axis with it is another The consistent mode of the scan axis of one electromagnet, to configure above-mentioned multi-diaphragm collimator.

In addition, the therapy planning device of the present invention is characterized in that, including：Three-dimensional data generation unit, the three-dimensional data Generation unit generates three-dimensional data according to the image data of irradiation object；Irradiate condition setting unit, irradiation condition setting Unit sets irradiation condition based on the three-dimensional data generated；And control data generating unit, control data generation are single Member is based on set irradiation condition, to generate the leaf for controlling to the multi-diaphragm collimator in above-mentioned particle-beam therapeutic apparatus The control data for the driving that piece is carried out, above-mentioned three-dimensional data generation unit is at least with the beam centered on above-mentioned 1st axis Deflection angle and the beam centered on above-mentioned 2nd axis deflection angle, to generate above-mentioned three-dimensional data.

Invention effect

Multi-diaphragm collimator according to the present invention, particle-beam therapeutic apparatus and therapy planning device, due to can be more The face for making the vane plate for being formed as profile when leaf collimator is formed through shape and the diffused sheet through the particle beams near the face To consistent, therefore, it is possible to the influence from penumbra, and the irradiation field that degree of being contrasted is higher.

Description of the drawings

Fig. 1 is for the particle-beam therapeutic apparatus to including the multi-diaphragm collimator involved by embodiments of the present invention 1 Irradiation system the figure that illustrates of structure.

Fig. 2 is for the particle-beam therapeutic apparatus to including the multi-diaphragm collimator involved by embodiments of the present invention 1 Irradiation system the structure side view that illustrates and observed from 2 direction vertical with the center of beam.

Fig. 3 is for the band in the irradiation system to the particle-beam therapeutic apparatus involved by embodiments of the present invention 1 The figure that the beam state of electrochondria beamlet illustrates.

Fig. 4 is shown in order to illustrate the multi-diaphragm collimator involved by embodiments of the present invention 1 and the structure of vane plate Full closeding state figure.

Fig. 5 is shown in order to illustrate the multi-diaphragm collimator involved by embodiments of the present invention 1 and the structure of vane plate Formation predetermined shape irradiation field state figure.

Fig. 6 is to represent that the beam in particle-beam therapeutic apparatus involved by embodiments of the present invention 2 scans showing for track The figure of example.

Fig. 7 be represent in particle-beam therapeutic apparatus involved by embodiments of the present invention 2 beam scanning track its Its exemplary figure.

Fig. 8 is for the structure of particle-beam therapeutic apparatus and multi-diaphragm collimator involved by embodiments of the present invention 5 The figure illustrated.

Fig. 9 is the figure illustrated for the flow to medical act.

Figure 10 is the frame illustrated for the structure to the therapy planning device involved by embodiments of the present invention 6 Figure.

Specific embodiment

Embodiment 1.

In the following, to multi-diaphragm collimator and the structure of particle-beam therapeutic apparatus involved by embodiments of the present invention 1 It illustrates.Fig. 1~Fig. 5 is for the multi-diaphragm collimator and particle-beam therapeutic involved by embodiments of the present invention 1 The figure that the structure of device illustrates, Fig. 1 are the irradiation systems for representing the particle-beam therapeutic apparatus for including multi-diaphragm collimator The figure of structure, Fig. 2 be in order to represent the structure of particle-beam therapeutic apparatus and multi-diaphragm collimator and the charged particle from Fig. 1 The figure that center (z directions) vertical direction of beam is observed, Fig. 2 (a) is the side view observed from y directions, and Fig. 2 (b) is from x The side view that direction is observed.Fig. 3 is said for the shape of the beam in the irradiation system to particle-beam exposure apparatus Bright figure, Fig. 3 (a) represent the figure of the overall appearance of beam；Fig. 3 (b) and Fig. 3 (c) is the charged particle beam from Fig. 3 (a) The figure observed of center (z directions) vertical direction, Fig. 3 (b) is the side view observed from y directions, and Fig. 3 (c) is from x side To the side view observed.In addition, Fig. 4 and Fig. 5 is for the main composition to multi-diaphragm collimator and as multi-diaphragm collimator The figure that the structure of the vane plate of body is illustrated and observed from all directions.

As the premise that the structure to multi-diaphragm collimator is described in detail, first, to including the particle of multi-diaphragm collimator The irradiation system of beam therapeutic apparatus illustrates.As shown in Figure 1, 2, particle-beam therapeutic apparatus 10 includes：Oscillating electromagnetic iron 1 (upstream 1a, downstream 1b), the oscillating electromagnetic iron 1 play the role of irradiating mouth, by adding on circuit orbit to not shown The charged particle beam B for the so-called form of a stroke or a combination of strokes that fast device provides is scanned, so as to expand irradiation field；Ridged filter 2, ridged filtering Device 2 is used to expand the width of cloth La Gefeng according to the thickness of irradiation object；Range shift unit 3, the range shift unit 3 are used for root Change the energy of charged particle beam B (range) according to the depth (depth of shine) of irradiation object；Link stopper collimator (block Collimator) 4, which is used for the irradiation field after will be enlarged by and is limited in prescribed limit, to prevent to normal group It knits and carries out unnecessary irradiation；Multi-diaphragm collimator 5, the multi-diaphragm collimator 5 is by multiple vane plates and the leaf of each vane plate of driving Piece driving mechanism is formed, for limiting irradiation field so that it is consistent with affected part shape；And object block 6, the object block 6 limit charged The range of particle beams B is so that it is consistent with the depth shape of irradiation object.

Next, to irradiating mouth by the work in the widened irradiation system of irradiation field and original by using swing method Reason illustrates.

Charged particle beam B is accelerated by accelerator (not shown), and is fed to via Transmission system in irradiation system, to make For diameter several below mm so-called pencilbeam.Oscillating electromagnetic iron 1 is scanned the beam being directed into irradiation system, with It is made to depict circuit orbit.Oscillating electromagnetic iron 1 is general as shown in Figure, prepares x directions electromagnet 1a and y directions electromagnetism Iron 1b, and it is configured to the central shaft X for making 2 electromagnet along charged particle beam B_BIt is connected.Herein, in order to make explanation clear, Define x directions and y directions.Coordinate system can be defined according to various standards, and this specification is sat according to following standard to define Mark system.The direction of advance of charged particle beam B is set to the positive direction of z-axis.X-axis and y-axis are the axis orthogonal with z-axis, and x-axis with Y-axis is mutually orthogonal.Also, xyz coordinate systems are right-handed coordinate systems.In Fig. 1,2 example, upstream oscillating electromagnetic iron 1a is along x side It is scanned to beam, downstream oscillating electromagnetic iron 1b is in the y-direction scanned beam.Pass through sweeping for 2 electromagnet 1a, 1b It retouches, irradiation field is extended along xy directions (in-plane).

Expand the charged particle beam B after irradiation field and pass through ridged filter 2.So that multiple such as bullets or section are three Angular plate is arranged in the mode in face to form ridged filter, if for example multiple zonules will be divided into irradiation field, In the presence of the beam for passing through different-thickness compared with each zonule.In the figure for easy understanding, it is recorded as cone such as sword Mountain arranges like that.The width S OBP (Spread-Out Bragg Peak) of cloth La Gefeng is extended as a result,.That is, ridged is passed through Filter 2, also in the z-direction spreads irradiation field.Next, the charged particle beam B expanded after irradiation field passes through range Shift unit 3.Range shift unit 3 is for changing the device of the energy of charged particle beam B.By range shift unit 3, can will expand Irradiation field after big is irradiated to desirable internal depth.Next, it is collimated by the beam after range shift unit 3 by block Device 4.Block collimator 4 is provided with metal derby of through hole PH etc., diffusion of the limitation irradiation field on in-plane (x/y plane). If this is because being limited previously against scope is penetrated, it can prevent normal tissue from carrying out unnecessary irradiation.

Next, charged particle beam passes through multi-diaphragm collimator 5.As being described in detail below, multi-diaphragm collimator 5 is used for Using according to multiple vane plates 5_LPosition and the transmission shape PS that is formed, irradiation field is constrained to consistent with affected part shape.That is, Using multi-diaphragm collimator 5, irradiation field is limited on xy directions and makes its shaping.In addition, it is at least wrapped in multi-diaphragm collimator 5 Include vane plate 5_L(it is as a whole blade group 5_G) and vane drive mechanism.But if vane drive mechanism can represent The driving track of blade, then the structure of itself is unimportant.If further, since record vane drive mechanism in itself with figure, Expression vane plate 5 can then be made_LStructure become difficult, therefore, in figure 1 above, 2 and attached drawing below, in order to be simplified, Among multi-diaphragm collimator 5, only by vane plate 5_LOr merge vane plate 5_LThe vane plate group 5 obtained afterwards_GPart extract out and remember It carries.

Finally, charged particle beam B passes through object block 6.Object block 6 is the limiter made of resin etc., is rendered as affected part depth Shape, for example, be formed as compensate affected part end (Distal) shape form.Terminal end shape refers to the concave-convex in most deep Shape.Herein, the energy of irradiation field is limited and (shaped in a z-direction), and with the shape identical with terminal end shape.That is, utilize Object block 6 in a z-direction limits irradiation field and makes its shaping.

The effect of the irradiation system of particle-beam therapeutic apparatus is, the irradiation field being irradiated is made to be formed as and affected part one It causes.As this method, swing method is used in the particle-beam therapeutic apparatus involved by present embodiment 1, in the swing method, Expand irradiation field merely with oscillating electromagnetic iron 1.The specific example of this method be shown in such as patent document 3 " pass through spiral shell Rotation beam scans and realizes large area and uniform irradiation ", spiral swing method is also referred to as in swing method.In brief, Spiral swing method is that spirally beam is scanned to expand the method for irradiation field, by improving the scanning in the irradiation field Track (scanning track) ensures flatness.In addition, the scanning track of the beam formed by spiral swing method may refer to patent Fig. 1 of document 3 etc..

On the other hand, swing method generally refers to single circle swing method more, in the case, passes through scattering object when expanding irradiation field To ensure flatness.Therefore, even if in identical swing method, there is also have using the situation of scattering object and without using scattering object Situation, the directionality of beam is also different due to the presence or absence of scattering object.In the case where using scattering object, due in scattering object Beam is spread in entire surface, therefore, width is generated on the direction of illumination of the beam by some point.On the other hand, such as Spiral swing method spreads beam like that without using scattering object using only scanning electro-magnet, in the case, passes through some point The direction of illumination of beam be mainly by leaving the position of scanning electro-magnet and a definite direction.

Fig. 3 is represented in the irradiation system of the particle-beam therapeutic apparatus 10 involved by present embodiment 1, utilizes two-stage Diffusion way (the beam F of beam caused by scanning electro-magnet 1_BShape) schematic diagram.In spiral swing method, beam is such as It spreads as shown in Figure 3 rather than point light source formula is spread.For convenience of description, the diffusion way of the beam shown in Fig. 3 is claimed For " diffusion of two-stage scan formula ".It is not point light source in beam, and carries out when two-stage scan formula is spread, it is necessary to design one and this phase Suitable limiter.

Here, some detailed description additional to the diffusion of two-stage scan formula.

As shown in figure 3, (z directions) is irradiated beam B from the top to the bottom.Beam B is penetrated originally with being called the form of a stroke or a combination of strokes The thinner state of beam is provided.In beam axis X_BOn, it is set with datum mark CPa and datum mark CPb.Datum mark CPa is believed that It is that configuration upstream oscillating electromagnetic iron 1a (scrupulously says it is scan axis A_sa) position, similarly, datum mark CPb is regarded as configuring Downstream oscillating electromagnetic iron 1b (scrupulously says it is scan axis A_sb) position.

The upstream oscillating electromagnetic iron 1a for being configured at datum mark CPa is scanned beam on the basis of datum mark CPa.Upstream The scanning direction of the beam of oscillating electromagnetic iron 1a is the direction that (xz planes) is scanned in the plane of Fig. 3 (b), and is passed through Beam axis X_BOn datum mark CPa, with beam axis X_BVertical axis A_saAs the effect axle (scanning of upstream oscillating electromagnetic iron 1a Axis).In addition, the downstream oscillating electromagnetic iron 1b for being configured at datum mark CPb is scanned beam on the basis of datum mark CPb.Under The scanning direction of the beam of trip oscillating electromagnetic iron 1b is the direction that (yz planes) is scanned in the plane of Fig. 3 (c), and is led to Cross beam axis X_BOn datum mark CPb, with beam axis X_BAnd axis A_saVertical axis A_sbAs the effect of downstream oscillating electromagnetic iron 1b Axis (scan axis).That is, the scanning direction (x) of upstream oscillating electromagnetic iron 1a and the scanning direction of downstream oscillating electromagnetic iron 1b (y) with beam axis X_BVertically, also, the scanning of the scanning direction (y) of downstream oscillating electromagnetic iron 1b and upstream oscillating electromagnetic iron 1a Direction (x) is vertical.

In addition, using Fig. 3 to above-mentioned beam F_BShape carry out geometry explanation.

As shown in Fig. 3 (b), vertical (z directions) line segment using datum mark CPa as upper extreme point is drawn, and base is removed on line segment The position beyond CPa sets datum mark CPb on schedule.Line segment is made only to rotate ± α degree centered on datum mark C Pa, obtains line at this time Section by fan-shaped Fsa.Sector Fsa is equivalent to the diffusion of beam when using only upstream oscillating electromagnetic iron 1a.It is next, sharp With the reference axis A by datum mark CPb_sbIt is top half and the latter half by fan-shaped Fsa points.Make the latter half of fan-shaped Fsa Compared with reference axis A_sbOnly rotation ± β degree, obtain at this time fan-shaped Fsa the latter half by region.In Fig. 3 (c), the region The region of fan-shaped Fsb can be seen as, the region show beam diffusion way (beam energy by region：Beam F_B). That is carry out the beam F of two-stage scan formula diffusion_BShape be formed as the different fan of radius of curvature on x directions and y directions Shape.

In view of as described above by using scanning direction different 2 scanning electro-magnets 1a, 1b expanding irradiation field and Generate, to beam carry out two-stage scan formula diffusion after beam F_BShape, it is leafy involved by embodiments of the present invention Collimator 5 is used to properly form the higher irradiation field of contrast in the case where influencing from half shadow bands.That is, the present invention's Among multi-diaphragm collimator 5 involved by embodiment 1, each vane plate 5_LWith with its adjacent vane plate in a thickness direction Actual opposite face P_LIt is formed in a plane, the plane is in the beam axis X of electrochondria beamlet B_BIt is upper and comprising being set in datum mark The scan axis A of scanning electro-magnet 1a on C Pa_saInside, along to be set in beam axis X_BOn datum mark CPb on scanning The scan axis A of electromagnet 1b_sbCentered on circular orbit, to each vane plate 5_LIt is driven, scanning electro-magnet 1b's sweeps Retouch axis A_sbWith beam axis X_BAnd scan axis A_saVertically.

In the following, it is described in detail using Fig. 4,5.Fig. 4 be in order to illustrate multi-diaphragm collimator and in multi-diaphragm collimator into The structure of the vane plate of row driving and the figure of the state of the blade under the full closeding state that shows, Fig. 4 (a) is multi-diaphragm collimator The cross-sectional view of blade group entirety；Fig. 4 (b) is the upper surface perspective view observed from the P directions of Fig. 4 (a), Fig. 4 (c) be from The front perspective view that the F directions of Fig. 4 (a) are observed, Fig. 4 (d) are the left sides of the multi-diaphragm collimator from the S directions of Fig. 4 (a) The side perspective view for the rows of blades divided.In addition, Fig. 5 is to represent to form the figure of the state of the irradiation field of predetermined shape, Fig. 5 (a) is The outside drawing of the blade group entirety of multi-diaphragm collimator；Fig. 5 (b) is the upper surface perspective view observed from the P directions of Fig. 5 (a), figure 5 (c) is the front perspective view observed from the F directions of Fig. 5 (a), and Fig. 5 (d) is the multi-diaphragm collimator from the S directions of Fig. 5 (a) Left-half rows of blades side perspective view.

As shown in Figure 4,5, multi-diaphragm collimator 5 has multiple vane plates 5_LAn end face E_LIt aligns and is arranged in thickness 2 row's rows of blades (5 on direction_c1、5_c2：It is collectively referred to as 5_c), and including：Blade group 5_G, the blade group 5_GIt is arranged so that blade Row 5_c1With 5_c2An end face E_LToward each other；And vane plate driving mechanism (not shown), vane plate driving mechanism driving Each vane plate 5_LSo that it is closer or far from vane plate corresponding thereto, each vane plate 5_LShape be as each blade The true form of the plate interarea of plate, i.e. the opposite face P with adjacent vane plate_LIt is formed at charged comprising expanding in the x direction The scan axis A of the scanning electro-magnet 1a of particle beams B_saPlane inside.That is, plate interarea is formed at comprising scanning electromagnetism The scan axis A of iron 1a_sa2 planes inside, after cutting off vane plate in comprising the plane including direction of illumination and thickness of slab direction Cross section thickness with the direction of illumination from charged particle beam B upstream side downstream side and it is thickening.

Also, by each blade 5_LDriving track (direction in yz planes) be set to circular orbit O_L, the circular orbit O_LWith the scan axis A apart from downstream electromagnet 1b_sbDistance it is corresponding, downstream electromagnet 1b is in y-direction to charged particle Beam B is enlarged, moreover, in vane plate 5_L4 end faces in, with an end face E_LThe end face P of adjacent light incident side_IShape, And the end face P of emitting side_XBe respectively shaped to scan axis A_sbCentered on circular arc, that is to say, that by formed with A part for annulus centered on scan axis Asb, even if so as to circumferentially track O_LDriving blade plate 5_L, along charged particle The depth dimensions of the direction of illumination of beam B does not also change.

As a result, no matter by vane plate 5_LDriving is to which position, such as shown in figure 5, makes to be formed through shape PS in x side The vane plate 5 of upward profile_LEnd face E_LWith passing through end face E_LThe direction of illumination of neighbouring charged particle beam B is parallel, so as to not Generate penumbra.In addition, make to form the vane plate of the profile through shape PS in y-direction 5_LOpposite face P_LWith passing through opposite face P_LThe direction of illumination of neighbouring charged particle beam B is parallel, so as to not generate penumbra.That is, it is formed in multi-diaphragm collimator 5 The outline portion through shape PS in there is no the part for generating half shadow bands, thus, it is possible to be formed to be suitable for affected part shape and correct Irradiation field.

As long as that is, each vane plate 5 of the multi-diaphragm collimator 5 involved by embodiments of the present invention 1_LIn thickness Shape and driving track O on direction_LWith the beam F of charged particle beam B_BDiffusion shape it is identical.As swept to two-stage Retouch passable scope when the scan angle of electromagnet 1a, 1b is limited respectively.It even can be described as the beam from beam source The position of charged particle beam when propagation distance is in the range of some.Since multi-diaphragm collimator 5 is by being stacked vane plate 5_LAnd It obtains, therefore, that after formation is also the beam F of charged particle beam through shape PS_BDiffusion shape.In addition, it is formed as a result, Be not dependent on opening shape through the opening (profile) of shape PS, make as opening it is wall surface, towards vane plate 5_LIrradiation The end face E of the Yezhong heart_LAnd the opposite face P with adjacent blades plate_L, with the direction of illumination phase by the charged particle beam near the face Unanimously.Therefore, it is possible to solve the problems, such as the caused penumbra when using two-stage scan electromagnet 1a, 1b.In addition, flat to improve For the purpose of degree and in the case of being irradiated using scattering object, generated in the distribution of the direction of illumination of above-mentioned two-stage scan formula Width.Therefore, even if in the case where using the multi-diaphragm collimator 5, a part of charged particle beam can also be irradiated to vane plate End face E_LOr opposite face P_LOn, compared with the situation without using scattering object, the effect for inhibiting half shadow bands decreases, but with Existing simple bullet multi-diaphragm collimator is compared, the effect for half shadow bands that can be inhibited.

In addition, in the multi-diaphragm collimator 5 involved by the above embodiment 1, using the position of upstream side electromagnet 1a as base Standard sets the shape of thickness direction, sets on the basis of the position of downstream side electromagnet 1b driving track O_L, but simultaneously not only It is limited to this, opposite setting can also be carried out.Therefore, electromagnet 1a in upstream is scanned x directions, and downstream electromagnet 1b is to y Direction is scanned, but may be reversed.In addition, each vane plate 5 of regulation is shown in figure_LThickness opposite face P_LBetween Angle it is equal, it is not limited to this.Even if the effect of unequal above-mentioned half shadow bands that can also be inhibited.Also, with " in fact In matter " come to show opposite face be because opposite face is stacked in a thickness direction, and is for being distinguished with substantially adjacent blade Face, it will be appreciated that be：For example, even if being formed with to form ditch or groove of driving track etc. in opposite face, also formed In the scan axis A including being set in the scanning electro-magnet 1a on datum mark CPa_saIn plane inside.In addition, rows of blades 5_C1、5_C2 Each blade 5_LMan-to-man pair state is rendered as, but it is also not necessarily paired.In addition, rows of blades is also not necessarily 2 Row, for example, in the case where only one arranges, as long as in the end face E of vane plate_LNear beam axis X_BWhen, it is close to simultaneously with stationary plane Stop beam B.Alternatively, it is also possible to several columns.

In addition, as the method for expanding irradiation field, the scanning spiral spiral swing method in track is illustrated, but As illustrating in embodiment as be described hereinafter, other spiral swing methods can also be used, and are not limited only to spiral pendulum Dynamic method.In addition, the electromagnet for playing irradiation mouth function is also not limited to oscillating electromagnetic iron 1, as long as it is different using scanning direction 2 electromagnet expand the irradiation mouth of irradiation field.

As described above, the multi-diaphragm collimator 5 involved by 1, the multi-diaphragm collimator are configured to utilize according to the present embodiment Scanning electro-magnet 1 come expand after irradiation field it is illuminated go out charged particle beam B in, be suitable for irradiation object i.e. affected part for being formed The irradiation field of shape, and the multi-diaphragm collimator 5 includes：Rows of blades 5_C, the rows of blades 5_CMake multiple vane plates 5_LAn end face E_LIt aligns and makes its arrangement in a thickness direction；And vane plate driving mechanism, the vane plate driving mechanism drive each blade Plate 5_L, so that an end face E_LCompared with the beam axis X of particle beams B_BOr compared with vane plate corresponding thereto closer or far from, Each vane plate 5_LAmong, the opposite face P of vane plate and adjacent with vane plate vane plate on thickness direction (x directions)_LShape Into in plane P_SaOn, plane P_SaInclude 1 axis, that is, scan axis A_sa, the 1st axis is set in the beam axis X of charged particle beam B_BOn 1 position, that is, datum mark CPa and with beam axis X_BVertically, vane plate driving mechanism is along with 2 axis, that is, scan axis A_sbFor in The circular orbit O of the heart_LCarry out driving blade plate 5_L, the 2nd axis is set in beam axis X_BOn 2 positions, that is, datum mark CPb and with Beam axis X_BAnd the 1st axis A_saVertically, since multi-diaphragm collimator 5 has a structure in which, form the saturating of multi-diaphragm collimator 5 Cross the opposite face P of the profile of shape PS_LOr end face E_LDirection and charged particle beam B beam F_BDiffusion way it is consistent, so as to It can inhibit the influence of penumbra and correct irradiation field is formed according to the shape of irradiation object.

Further, since in vane plate 5_LIt, will be with an end face E in main 4 end faces_LAdjacent surface, that is, charged particle beam B Light incident side end face P_IAnd the end face P of emitting side_XBe shaped so as to it is arc-shaped centered on the 2nd axis i.e. scan axis Asb, Therefore, it is possible to be easy to circumferentially track O_LCarry out driving blade plate 5_L.In addition, driving blade plate 5 anyway_L, along band electrochondria The depth dimensions of the direction of illumination of beamlet B does not also change, so that constant for covering the distance of charged particle beam.

In addition, the particle-beam therapeutic apparatus 10 involved by embodiments of the present invention 1 includes：Oscillating electromagnetic iron 1, the pendulum Motor magnet 1 is scanned the charged particle beam B provided by accelerator using scanning direction different 2 electromagnet 1a, 1b And it is irradiated to expand irradiation field；And above-mentioned multi-diaphragm collimator 5, which is configured at is irradiated by irradiation mouth 1 Charged particle beam B (i.e. beam F_B) in, the 1st axis of multi-diaphragm collimator 5 and an electromagnet in above-mentioned 2 electromagnet Scan axis (A_saOr A_sb) unanimously, and the scan axis (A of the 2nd axis and another electromagnet_sbOr A_sa) unanimously, according to such knot Structure can inhibit the influence of penumbra and irradiate charged particle rays using irradiation field corresponding with the shape of irradiation object.

Embodiment 2.

In embodiment 1, elaborate to carry out beam the application of the spiral swing method of helical form scanning.However, beam Scanning trade shape (scanning track) in irradiation field is not limited in the technological thought of the present invention, and rail is scanned in other beams In mark, effect can also have been given play to by carrying out the situation of two-stage scan formula diffusion.Therefore, in present embodiment 2, by the more of the present invention Leaf collimator is applied in the irradiation system with other representative beam scanning tracks, which is illustrated.

First, to obtained from the spiral swing method used in embodiment 1 beam scanning track illustrate. As described in patent document 3, helical form scanning track is obtained according to the formula (1) including following 3 equatioies.

(mathematical expression 1)

∴

Radius when wherein, by time t=0 is set to R_min, radius during by time t=T is set to R_max, by scanning times It is set to N.In addition, r (t) is the coordinate of radial direction；θ (t) is the coordinate of angle direction, i.e., is represented by polar coordinate system.

The beam scanning track obtained according to above-mentioned formula (1) in the shape of a spiral, the shape be in order in border circular areas to penetrating Beam is scanned and obtains the valid shape of uniform dosage distribution.But uniform dosage distribution in order to obtain, it is not necessary to will penetrate Beam scanning track is defined to helical form.It is believed that for obtaining the beam that uniform dose is distributed by the scanning of 2 electromagnet Scanning track can be categorized into several typical patterns.

Swing method is that the method for forming uniform dosage distribution is routinely scanned to beam.That is, preferably put Beam scanning track in dynamic method is continuous and with periodic.Therefore, to representing beam trajectory using polar coordinate system, and R (t) and θ (t) is made to carry out continuous and periodically variable pattern to discuss.

<Typical pattern 1>

In the first pattern, r (t) and θ (t) are as follows, are defined as carrying out continuous and periodically variable function.

R (t)=continuously and with periodic function (cycle T₁)

θ (t)=continuously and with periodic function (cycle T₂),

In addition, different value can be used in the cycle of r (t) and θ (t) at this time.Furthermore, it is noted that angle, θ, 360 degree can be considered rotation 0 degree obtained after circling.That is, 360 degree are continuous with 0 degree.If represented with radian, 2 π can be seen as 0.

As the example for realizing above-mentioned pattern, the beam shown in the formula (2) including following 3 equatioies can be included Scan track.

R (τ)=r₁+r₂sin(ω_rτ+φ_r)

θ (τ)=ω_θτ···(2)

τ=τ (t)

Wherein τ (t) is the parameter of the above-mentioned formula (2) represented by parameter, is the function of time.ω_rIt is to determine the angle of r (t) Speed, the cycle of r (t) is 2 π/ω_r。φ_rIt is initial phase.ω_θBe to determine the angular speed of θ (t), cycle of θ (t) for 2 π/ ω_θ。

As shown in fig. 6, show that the beam generated by formula (2) scans the example of track ST1.Fig. 6 be represent be in The figure of scanning track in some vertical plane of beam axis, transverse axis x, the longitudinal axis y, x and y are respectively by standardization.In addition, In formula (2), parameter is not set to time t and is to be able to change depicting speed according to different situations.For example, In Fig. 6, with coordinate (0,0) for beam axis central part, due to beam scanning more concentration and the density near beam axis central part It is higher, therefore, in the part that the track as close to the part of central part is concentrated, try, by sweep speed quickening etc., thus to obtain It is distributed to uniform dosage.

<Typical pattern 2>

In second of pattern, multiple functions for defining depicting pattern are combined to form beam scanning track.Example Such as, combination of function of the function of larger circle with describing smaller circle will be described.Formula (3) including following 3 equatioies is shown One of example is gone out.

X (τ)=r₁cos(ω₁τ+φ₁)+r₂cos(ω₂τ+φ₂)

Y (τ)=r₁sin(ω₁τ+φ₁)+r₂sin(ω₂τ+φ₂)···(3)

τ=τ (t)

Wherein, x (τ) is respectively x coordinate, the y-coordinate of beam scanning track, is orthogonal coordinate system.It shows and passes through in Fig. 7 The example of the beam scanning track of mathematical expression (3) generation.Fig. 7 as Fig. 6, is represented in some vertical with beam axis The figure of scanning track in plane, transverse axis x, the longitudinal axis y, x and y are respectively by standardization.

There is a kind of stage property in toy, formation inside it has the disk that gear-like is set in the round hole of tusk, And nib is inserted into the aperture on the assigned position being arranged in disk, disk is made to be rotated along round hole several so as to depict What learns pattern, and geometry pattern falls within the category made of the stage property.In addition, it is referred to as by the curve that the stage property is depicted Length width hypocycloid (hypotrochoid) is geometrically being defined as below the curve, i.e., when using radius as r's Circle as activity circle, using apart from the activity circle centre distance as Ir point as pinpoint when so that radius for r circle and radius For the mode of the circumference inscribe of kr, as obtained from activity circle is made not rotated slidably compared with the circumference that the radius is r Track.In addition, in most agitating device, which is used for the driving pattern of mixing part.In addition, the example one with front Parameter is not set to time t, which is because, to enable changing depicting speed depending on the situation by sample.

As described above, in method continuous and that there is periodic pattern (line chart) is described using oscillating electromagnetic iron, The pattern is not limited to helical form.However, without using scattering object and by design beam trajectory realize large area and uniformly The idea of irradiation come from " spiral swing method ", therefore, these methods shown in embodiment 2 are also referred to as the spiral of broad sense Swing method.Also, in the spiral swing method of these broad sense, the diffusion way of beam is also not point light source formula, but two-stage is swept Retouch formula.

That is, the particle ray of the irradiation system with the spiral swing method using broad sense in present embodiment 2 It in therapeutic device, applies in embodiment 1 and multi-diaphragm collimator is shown, therefore, it is possible to make each vane plate in a thickness direction Shape and driving track, the beam F with charged particle beam B_BDiffusion shape it is identical.Therefore, the transmission shape PS formed For the beam F of charged particle beam B_BDiffusion shape, formed and be not dependent on opening shape through the opening portion of shape PS, but made The end face at irradiation field center as its wall surface, towards vane plate and the opposite face with adjacent blades plate, with charged particle beam Direction of illumination it is consistent.Therefore, it is possible to solve the problems, such as the caused penumbra when using two-stage scan electromagnet.

Embodiment 3.

In the above embodiment 1 and 2, situation about being irradiated using swing method is set forth.However, as above institute It states, illuminating method is not the substantial portion of the present invention in itself, to technological thought of the invention and will not be not limited.In particle In beam therapeutic apparatus, it is proposed that a kind of spot scan method, the scanning method carry out charged particle beam using two-stage scan electromagnet Scanning, and an irradiation is carried out in a manner of description to irradiation object.In the case of spot scan, the diffusion way of beam is also two Grade scan-type.Therefore, in the case of using multi-diaphragm collimator in spot scan, it can also give play to and inhibit above-mentioned penumbra and formed The effect of the higher irradiation field of contrast.

Embodiment 4.

In embodiment 3, elaborate to the multi-diaphragm collimator point of application scanning method involved by embodiments of the present invention Situation.As spot scan method, also there are raster scanning method, the raster scanning method is using two-stage scan electromagnet to beam It is scanned, and irradiation object is irradiated in a manner of single stroke (one-stroke writing) into line raster.Into line raster In the case of scanning, the diffusion way of beam is also two-stage scan formula.Therefore, the feelings of multi-diaphragm collimator are used in raster scanning Under condition, the multi-diaphragm collimator 5 involved by the above embodiment of the invention can give play to effect.That is, it is swept by point It retouches or the scanning methods such as raster scanning is come in the case of expanding irradiation field, if using the leafy standard involved by embodiments of the present invention Straight device 5 can then give play to the effect for inhibiting above-mentioned penumbra and the higher irradiation field of degree of being contrasted.

Embodiment 5.

In particle-beam therapeutic apparatus, such as recorded in patent document 4, it is proposed that following scheme： I.e. by designing the control method of deflection electromagnet, so as to omit one in two scanning electro-magnets.However, due to so Irradiation system in, the deflection electromagnet for changing orbital direction (direction of beam axis) is scanned charged particle beam, To replace the scanning electro-magnet being omitted, therefore, beam also carries out two-stage scan formula diffusion, so that in the above embodiment Multi-diaphragm collimator has given play to the effect for inhibiting penumbra.

Fig. 8 is the irradiation system including the multi-diaphragm collimator for representing to possess in the particle-beam therapeutic apparatus of embodiment 5 Partial figure.The charged particle beam B provided in the figure for (x directions) from horizontal direction, will be penetrated using electromagnet 201a is deflected Beam axis deflects to vertical direction, after by scanning electro-magnet 201b, as embodiment 1, via ridged filter 2, penetrates Journey shift unit 3, annular collimator 4, multi-diaphragm collimator 205 and agglomerate 6, are irradiated to irradiation object.Also, in present embodiment 5 Particle-beam therapeutic apparatus 210 and 1 structure of embodiment the difference is that：Deflection electromagnet 201a is set, to substitute Scanning electro-magnet 1a in the particle-beam therapeutic apparatus 10 of embodiment 1；And the shape of the vane plate of multi-diaphragm collimator 205 and The setting benchmark of track is different.

The beam axis P of the charged particle beam B provided from horizontal direction in the figure_XIn the inside one of deflection electromagnet 201a While circular arc is depicted as, while being deflected to z directions.At this point, usually magnetic is controlled such that in the case where using deflection electromagnet Field is constant, and therefore, the beam of charged particle beam B is not spread, however, in the case where using the deflection electromagnet 21, it should Electromagnet 21 is deflected by periodic variation magnetic field, so as to be scanned charged particle beam B so that beam in x directions In x directions from P_E1Diffuse to P_E2.That is, deflection electromagnet 201a plays the upstream scanning electro-magnet 1a in embodiment 1 Effect.Part afterwards and embodiment are essentially identical, scanning electro-magnet 201b make the beam being diffused in x directions again to It spreads in y directions.

The diffusion way of the beam may be regarded as the equivalent datum mark E in Fig. 8_AsOn there are upstream scanning electro-magnet 201a's Scan axis, along beam axis E_XThe beam being irradiated into from top is scanned in the x direction (comprising z directions ingredient), in x directions On from E_E1It is diffused into E_E2.In addition, in deflection electromagnet 201a, with the advance of beam, beam axis gradually deflects, because This, the beam axis of entrance side and the beam axis (=beam axis E of outlet side_X) different, scan axis E_ASIt is positioned away from deflection electromagnet Position outside 201a main bodys.However, it is beam axis E due to inciding into the beam axis in multi-diaphragm collimator 205_X, accordingly, it is capable to understand To provide scan axis E_ASPosition datum mark CPa be in incide on the beam axis of the beam in multi-diaphragm collimator 205, moreover it is possible to It is interpreted as scan axis E_ASIt is vertical with the beam axis for inciding into the beam in multi-diaphragm collimator 205.Therefore, as described above by one A electromagnet is also used as in the irradiation system of deflection electromagnet, can also be made with inciding into the beam axis of the beam in multi-diaphragm collimator On the basis of, equivalent scan axis E is calculated according to the diffusion way of beam_As, and as embodiment 1, utilize equivalent scanning Axis E_AsAnd scan axis A_sb(datum mark CPb) sets the shape of the vane plate of multi-diaphragm collimator 205 and track.

As shown in Figure 8, which is omitted a scanning electro-magnet, and makes the deflection electromagnet of curved in tracks 201a substitutes omitted scanning electro-magnet, in the case, with using the dedicated electromagnet of scanning (for example, embodiment 1 1a, 1b) compared the common irradiation system that is scanned, it is specified that equivalent scan axis E_AsThe datum mark CPa and base of (equivalent) The interval of CPb becomes larger on schedule.Therefore, it is assumed that carrying out in the multi-diaphragm collimator of the beam blow-up mode of point light source formula, generation half The problem of shadow, seems especially pronounced.However, what kind of no matter forms through shape, all so that formed face through shape contour with The identical mode in the direction of the diffusion of beam, to set each of the multi-diaphragm collimator 205 involved by embodiments of the present invention 5 The shape and track of vane plate.Therefore, it is possible to easily solve to be produced in the irradiation system that single scanning electro-magnet is omitted Raw more prominent penumbra problem.

As described above, in the particle-beam therapeutic apparatus 210 involved by present embodiment 5,2 directions x, y are carried out During scanning, one of them (x or y) is scanned using the deflection electromagnet 201a that the direction of beam axis deflects is made, And the beam axis for setting datum mark CPa, CPb is set to incide into the beam axis E of the beam in multi-diaphragm collimator 205_X, carry out The composition of multi-diaphragm collimator 205 and configuration, therefore, it is possible to inhibit penumbra and the higher irradiation field of degree of being contrasted.

Embodiment 6.

In above-mentioned each embodiment 1~5, to the knot of multi-diaphragm collimator and the irradiation system for having used multi-diaphragm collimator Structure, its beam trajectory are illustrated.In present embodiment 6, to involved by above-mentioned each embodiment of the setting present invention Multi-diaphragm collimator, the therapy planning device of operating condition of particle-beam therapeutic apparatus illustrates.

Here, before being illustrated to therapy planning device, before the treatment plan implemented to therapy planning device I.e. physician practice is carried to illustrate.Physician practice is can be generally considered as to be made of several stages.Fig. 9 shows the physician practice Stage (flow), and show the device used in each stage.Treatment flow is illustrated based on Fig. 9.

Specifically, it may be said that physician practice is substantially made of following each stage：The prediction diagnosis stage (MS1) examines Faulted-stage section (MS2), treatment plan stage (MS3), treatment stage (MS4) and rehabilitation later observation stage (MS5).Also, Especially when carrying out particle-beam therapeutic etc., the device used in above-mentioned each stage is the device shown on the right side of Fig. 9.Example Such as, the device used in diagnostic phases (MS2) is X-ray filming apparatus, CT (Computed Tomography：Computer Tomography), MRI (Magnetic Resonance Imaging：Nuclear magnetic resonance image) etc., at treatment plan stage (MS3) Used in device be known as the device of therapy planning device.Also, the device used in treatment stage (MS4) is Radiation treatment device or particle-beam therapeutic apparatus.

Next, each stage is illustrated.

It is carried out the stage of prediction diagnosis whether the prediction diagnosis stage (MS1) refers to be not dependent on morbidity.It is for example, fixed Phase physical examination or health examination etc. belong to this, for cancer, it is known to：Utilize the method for the fluoroscopy images of X-ray etc., profit With PET (Positron Emission Tomography：Positron Emission Computed Tomography), the tomographies such as PET/CT Method and the method etc. using genetic test (immune detection).

Diagnostic phases (MS2) carry out the stage diagnosed premised on treating after referring to morbidity.Carrying out particle ray In the case for the treatment of, in order to treated, it is necessary to obtain the position of affected part, shape three-dimensional information.Therefore, using can obtain The various CT of the three-dimensional data of affected part, MRI device.

The treatment plan stage (MS3) refers to the stage that treatment plan is set based on above-mentioned diagnostic result.Carrying out particle In the case of beta ray therapy, treatment plan is made using the therapy planning device involved by present embodiment 6 in this stage. The detailed description of therapy planning device below will be carried out, next proceed to illustrate remaining stage.

Treatment stage (MS4) refers to carry out the stage of actual treatment based on the result of above-mentioned treatment plan.Carry out In the case of particle-beam therapeutic, in this step using particle-beam therapeutic apparatus.Above-mentioned each embodiment of the present invention Involved multi-diaphragm collimator is used to form irradiation field in the irradiation system of particle-beam therapeutic apparatus.In addition, in treatment rank Duan Zhong there is also the situation that progress once irradiating therapeutic progresses just terminate, but usually requires repeatedly to be shone during certain section It penetrates.

As literal meaning, rehabilitation later observation step (MS5) refers to carry out rehabilitation or to whether recurring progress subsequently The stage of observation.In the case of cancer, the later observation carried out at this stage is as the prediction diagnosis stage, using as follows Method：It is examined using the method for the fluoroscopy images such as X-ray, using the method and utilization gene of the tomographies such as PET, PET/CT Method for surveying (immune detection) etc..

In physician practice as described above, treatment plan is after diagnostic phases, is carried out before treatment stage A series of operation.Due in particle ray diagnosing and treating apparatus, according to the obtained treatment plan of therapy planning device is utilized, shining Charged particle beam is penetrated, therefore, the therapy planning device in particle-beam therapeutic generally comprises the unit with effect as follows.

Act on A：The unit of three-dimensional data is generated by the image information of the multiple irradiation objects got in advance.

Act on B：The unit of optimal irradiation condition (treatment plan scheme) is generated based on the condition given.

Act on C：The distribution of final dosage is simulated for optimum results (treatment plan scheme) and it is shown Unit.

That is, therapy planning device plays the role of receiving the irradiation condition needed for diagnostic result setting treatment, moreover, this is controlled Treatment plan making device plays an important role of to play the control data D based on set condition, to generate particle-beam therapeutic apparatus etc. Unit.

In order to function as described above, therapy planning device also specifically has the function of as follows.

＜ effect A ＞

Function a：The function of three-dimensional data is generated by the tomography image obtained in diagnostic phases.

Function b：The function of generated three-dimensional data is shown from each visual angle as three-dimensional CAD.

Function c：Affected part and normal structure and the function of being stored to it are distinguished in the three-dimensional data generated.

＜ effect B ＞

Function d：The parameter of particle-beam therapeutic apparatus used in therapeutic progresses is set and simulates irradiation Function.

Function e：Under conditions of set by the user as the device, compare the function of penetrating and optimize.

＜ effect C ＞

Function f：Function in a manner of coinciding with above-mentioned three-dimensional data, to show the irradiation result after optimizing.

＜ effect D ＞

Function g：For the function of shape of realizing the irradiation after above-mentioned optimization and set multi-diaphragm collimator and object block.(bag Include more mouthfuls of irradiations in the case of hypothesis broad-beam condition irradiation)

Function h：The function of the irradiation track of beam is set in order to realize the irradiation after above-mentioned optimization.(assuming that scanning is shone Situation about penetrating)

Function i：The work(of the irradiation track for being used to implement above-mentioned beam and the driving code for generating particle-beam therapeutic apparatus Energy.

The other ＞ of ＜

Function j：Store the function of the various data generated in the apparatus.

Function k：By reading various data in store in the past, the function of past information can be recycled.

The system structure of therapy planning device to being used to implement above-mentioned each function illustrates.In recent years, treatment meter The manufacturer for drawing device hardly designs and manufactures intrinsic hardware, is grasped mostly with the Unix (registered trademark) sold in the market Based on making platform or PC, and its peripheral equipment also uses common apparatus mostly.That is, the manufacturer of therapy planning device is special It notes in the exploitation of therapy plot software, manufacture and selling.In therapy plot software, as the sub- journey recalled by main program Sequence prepares for example to realize the module of each function of function a~function k.For the flow in function a~function k or according to need It wants and omits or change condition to perform again, thus the user of therapy planning device can be while necessary module be recalled Formulate treatment plan.

Next, to each function or realize that the module of each function illustrates, to involved by embodiments of the present invention And therapy planning device illustrate.

(module a) generates three-dimensional data to function a by a series of tomography images obtained in diagnostic phases. It, also can be (slice spacings, slice thickness, FOV, disconnected according to the patient informations such as patient ID, scanning information when reading tomography image Layer shooting condition etc.) it is read out.Here, three-dimensional data refers in a manner of virtual and is three-dimensional come in therapy planning device It reappears comprising information necessary to the reference object including affected part.In general, using following method：Define treatment plan dress Interior Virtual Space is put, carrys out collocation point at equal intervals and in a manner of lattice-shaped in above-mentioned Virtual Space, and makes from tomography The material information being obtained in image corresponds to the point.The reasons why function is necessary function be, therapy planning device it is most heavy The first purpose wanted is to simulate treatment, maintain, it is necessary to reappear the affected part as irradiation object and its perienchyma.

(module b) shows the three-dimensional data of generation to function b from each visual angle as three-dimensional CAD.

(module c) can distinguish affected part and normal structure and stored function c in the three-dimensional data generated.For example, Assuming that tomography image is obtained using X ray CT.In this case, " material information " phase used in function a When in the complexity of X-ray transparent.The threedimensional model reappeared namely based on the tomography image in Virtual Space is by X The shape for the three-dimensional body that the different substance of the degree of Radiolucent is formed.For " material information " the i.e. X-ray transparent Complexity in the Virtual Space of therapy planning device, is indicated by changing such as color or brightness.In addition, it is based on It is somebody's turn to do " material information ", it can be until following information：That is, in the threedimensional model reappeared in Virtual Space, which is equivalent to Bone portion or the part are equivalent to the part of tumour, and can distinguish affected part and normal structure.Can will distinguish affected part with it is normal The result of tissue is stored into the storage device (hard disk etc.) of therapy planning device.

(module d) is set in the parameter of the particle-beam therapeutic apparatus used in treatment stage to function d, and simulates photograph It penetrates.The parameter of so-called particle-beam therapeutic apparatus refers to the geometry information, relevant with irradiation field of particle-beam therapeutic apparatus Information.Geometry information includes waiting centers, sleeps platform position etc..Include above-mentioned " base with the relevant information of irradiation field Coordinate of CPa and datum mark CPb on schedule " etc..In addition, further including multi-diaphragm collimator 5 or 205 (hereinafter only records 5 as generation Table) vane plate 5_LWidth (thickness), vane plate 5_LQuantity and vane plate 5_LThe parameters such as displacement distance (angle).

(based on the condition set by the user of the therapy planning device, control is penetrated to be optimized module e) function e.

(module f) is in a manner of coinciding with above-mentioned three-dimensional data to function f, carrys out the irradiation result after display optimization.

(module g) sets the shape of multi-diaphragm collimator 5 and object block 6 to function g in order to realize the irradiation after above-mentioned optimization.This Function assumes that function during broad-beam condition irradiation, includes the situation of leafy irradiation.

(module h) is to set the irradiation track of beam to realize the irradiation after above-mentioned optimization to function h.This function is false If carry out the function of spot scan or raster scanning when scannings.

(module i) generates the driving generation of particle-beam therapeutic apparatus to function i in order to realize the irradiation track of above-mentioned beam Code.At this point, as described below, according to the corresponding coordinate system of two-stage scan formula diffusion, then can make above-mentioned each reality Apply the multi-diaphragm collimator 5 shown in mode 1~5 and easily produce driving code, the driving code be used to implement with it is obtained Corresponding opening shape (penetrating shape SP) is planned in optimal irradiation.

Function j (the various data that module j) storages set and generate in the apparatus.

(module k) goes in store various data by reading to function k, thus, it is possible to reuse past information.

＜ coordinate system ＞s corresponding with the diffusion of two-stage scan formula

In existing therapy planning device, the three-dimensional data used in function for above-mentioned function a and afterwards, one As be indicated with orthogonal coordinate system (xyz coordinate systems).In the situation that the global shape of multi-diaphragm collimator is existing cuboid Under, since the driving direction of its configuration or blade is also to be represented by orthogonal coordinates direction (for example, x directions or y directions), because This, can represent three-dimensional data using orthogonal coordinate system.The reason is that make to generate opening portion shape according to affected part shape Shape data is consistent with blade driving data.

On the other hand, due in the case where using multi-diaphragm collimator 5 according to the present invention, vane plate 5_LDriving be in Curve, therefore be preferably to be used in the command value of driving blade as the angle centered on datum mark.That is, it is preferably, is used in The shape data of opening portion shape is correspondingly generated with affected part shape includes the form with blade drive command value of the invention Including identical and centered on datum mark angle.

Therefore, the therapy planning device involved by embodiments of the present invention 6 shows affected part using special coordinate system Three-dimensional data.

Specifically, the special coordinates system shown in (D1) is defined as below.

[ψ_a, ψ_b, r_b]·····(D1)

Wherein, ψ_aIt is the deflection angle of the beam centered on reference axis (Asa), the reference axis (Asa) and beam axis X_BIt hangs down It is straight and pass through datum mark CPa, ψ_bIt is the deflection angle of the beam centered on reference axis (As b), the reference axis (Asb) is with penetrating Beam axis X_BAnd reference axis A sa are vertical and pass through datum mark CPb, r_bIt is from datum mark CPb (or reference axis (As b)) to the irradiation Distance until point.

Arbitrary point in three dimensions can uniquely be represented by above-mentioned 3 information.Wherein, it is necessary to according to scanning electricity The configuration of magnet 1a, 1b predefine datum mark CPa and datum mark CPb.In addition it is also possible to using beam from datum mark CPa (or reference axis (Asa)) travels to the distance r until the point of irradiation_aDeng to replace rb.

Here, using irradiate benchmark i.e. wait centers as xyz coordinate systems origin, to datum mark CPa and datum mark CPb each Xyz coordinates carry out hypothesis as follows.

Datum mark CPa：(0,0 ,-l_a)

Datum mark CPb：(0,0 ,-l_b)

Also, upstream scanning electro-magnet 1a as shown in Figures 1 to 3, is assumed to be x scanning direction electromagnet, downstream is scanned Electromagnet 1b is assumed to be y scanning direction electromagnet.At this point, the coordinate of certain point in definition (D1) by showing by special coordinates system Represented [ψ_a, ψ_b, r_b] and obtain, at this point, the xyz coordinates of the point are represented respectively by following formula (4).

(mathematical expression 2)

Here, if Rot in the definition (4) as (D2)_x(ψ_b) and Rot_y(ψ_a), then certain point is obtained as formula (5) Xyz coordinates.

(mathematical expression 3)

On the contrary, it is as follows that the method for special coordinates system is obtained by xyz coordinate systems.

Due to l_bIt is the intrinsic value of irradiation system, therefore, it is possible to as formula (6), pass through the y in formula (5) and the pass of z It is ψ is obtained_b。

(mathematical expression 4)

Further, since l_aAnd the value that irradiation system is intrinsic, it is thus possible to it is enough as defining (D3), pass through formula (5) In y and the relation of z be defined,

Λ：=y²+(z+l_b)²+(l_a- l_b)···(D3)

=(l_a―l_b+r_b)cosψ_a

By the relation of the z in formula (5) and definition (D3), ψ is obtained using formula (7)_a。

(mathematical expression 5)

Finally, r can be obtained using formula (8)_b。

(mathematical expression 6)

Begin to use and the corresponding coordinate system [ψ of the beam blow-up of above-mentioned two-stage scan formula from the stage of function a_a, ψ_b, r_b].That is, in function a or as the miscellaneous function for perform function a, have what is converted to special coordinates system Coordinate system conversion function, the coordinate system conversion function perform in the case of assuming that carrying out two-stage scan.

For example, Figure 10 is the effect that the therapy planning device involved by embodiments of the present invention 6 is represented using block diagram The figure of the characteristic of (unit), function (module).Therapy planning device 20 includes in the figure：Three-dimensional data generation unit 21, The three-dimensional data generation unit 21 generates three-dimensional data according to the image data of the affected part as irradiation object；Irradiation condition is set Order member 22, the irradiation condition setting unit 22 set irradiation condition based on the three-dimensional data generated；And control data Generation unit 23, the control which generates particle-beam therapeutic apparatus based on set irradiation condition Data processed.In addition, as noted previously, as these units, module are formed at using software in computer, therefore, physics is not shown It is formed with the part to property.

Also, three-dimensional data generation unit 21 includes：Three-dimensional data generation module 21_M1, the three-dimensional data generation module 21_M1The three-dimensional data of affected part or build etc. is generated according to image data as function a；Coordinate transferring 21_M2, the coordinate Modular converter 21_M2The three-dimensional data generated is converted into define the coordinate system [ψ shown in (D1)_a, ψ_b, r_b] data, this is fixed Adopted (D1) is set up in the case of assuming that carrying out two-stage scan；Display data generation module 21_M3, display data generation mould Block 21_M3Display data are generated based on transformed data, using as function b；And irradiation object separation module 21_M4, should Irradiation object separation module 21_M4Affected part and normal structure as irradiation object, and three are distinguished based on transformed data Dimension data generation unit 21 is formed according to image information according to the three-dimensional data for defining the coordinate system shown in (D1) and generating, Using as effect A.

Also, irradiation condition generation unit 22 is based on according to three dimensions for defining the coordinate system shown in (D1) and generating According to, optimal irradiation condition is set using function d, e, using as effect B.Also, control data generating unit 23 includes：Through Shape setting module 23_M1, this penetrates shape setting module 23_M1It is set based on set irradiation condition by multi-diaphragm collimator 5 The transmission shape PS of formation, using as function g；And driving code generation module 23_M2, the driving code generation module 23_M2Base The driving code of each blade 5L of multi-diaphragm collimator 5 is generated through shape, using as function i, also, control in set Data generating unit 23 processed at least generates leafy standard based on set irradiation condition by defining the coordinate system shown in (D1) The control data of straight device 5, using as effect D.

As a result, in three-dimensional data generation unit 21 or irradiation condition setting unit 22, at least use with reference axis (Asa) Centered on the deflection angle of beam and the deflection angle of the beam centered on reference axis (Asb) provide to determine Irradiation position and define the three-dimensional data of coordinate system shown in (D1), wherein, the reference axis (Asa) and beam axis X_BIt hangs down It is straight and pass through datum mark CPa, the reference axis (Asb) and beam axis X_BAnd reference axis Asa is vertical and passes through datum mark CPb.Therefore, The driving code of the multi-diaphragm collimator 5 generated in data generating unit 23 is controlled is to be used to implement opening shape (through shape SP driving code), the opening shape are corresponding with as the optimal irradiation plan calculated by irradiation condition setting unit 22.Also It is to say, in the therapy planning device 20 involved by embodiments of the present invention 6, in the work(for the effect for being used to implement treatment plan Can have the function of to the conversion of special coordinates system among (module), and using the special coordinates system come regulation three-dimensional data, In, the special coordinates system in the case of carrying out two-stage scan assuming that use.Therefore, for corresponding with affected part shape The shape data and blade drive command value of ground generation opening portion shape can be by including the angle centered on datum mark (angle is used in rows of blades 5 identical form inside_CMiddle selection is with the opposite face P close to the angle_LVane plate 5_L) To represent.Therefore, it is possible to beam carry out two-stage scan formula diffusion irradiation system in, easily generate to multi-diaphragm collimator 5 into The optimally-controlled driving code of row.

Therefore, in the therapy planning device 20 involved by embodiments of the present invention 6, can inhibit for having used in grain The particle of the above-mentioned multi-diaphragm collimator 5,205 of half shadow bands is penetrated caused by the irradiation system of beamlet progress two-stage scan formula diffusion Beam therapeutic apparatus, in order to by with affected part shape it is corresponding in a manner of form the shape of opening portion, can directly utilize by treating Plan making device 20 exports or to the three-dimensional data that therapy planning device 20 inputs, to generate the drive command value of blade.

As it appears from the above, the therapy planning device 20 involved by 6 according to the present embodiment, including：Three-dimensional data generation unit 21, which generates three-dimensional data according to the image data of irradiation object, that is, affected part；Irradiation condition is set Order member 22, the irradiation condition setting unit 22 set irradiation condition based on the three-dimensional data generated；And control data Generation unit 23, the control data generating unit 23 at least generate particle-beam therapeutic apparatus based on set irradiation condition Control data in the above embodiment 1 to 5 involved by multi-diaphragm collimator 5 control data, due to three-dimensional data generate Unit 21 utilizes the deflection angle ψ by the beam centered on reference axis Asa_a, beam centered on reference axis (Asb) it is inclined Gyration ψ_bAnd distance r and defined coordinate system generate above-mentioned three-dimensional data, therefore, in order to opposite with affected part shape The mode answered forms the shape of opening portion, can directly utilize and is inputted to therapy planning device 20 or by therapy planning device 20 The three-dimensional data of output generates the drive command value of the blade, wherein, reference axis Asa and beam axis X_BIt is vertical and pass through base C Pa on schedule；The reference axis (Asb) and reference axis Asa and beam axis X_BIt is vertical and pass through datum mark C Pb；Distance r is to leave The distance of reference axis Asa or Asb or datum mark CPa or CPb.That is, in data generating unit 23 is controlled, due to 2 deflection angle ψ can be utilized_aAnd ψ_bProvide above-mentioned control data, therefore, which can be in particle In the irradiation system of Shu Jinhang two-stage scans formula diffusion inhibit half shadow bands, and higher using contrast and good beam carries out Irradiation, for particle-beam therapeutic apparatus, can carry out the irradiation that contrast is higher and precision is higher.

Label declaration

1：Oscillating electromagnetic iron (1a：X directions (upstream) scanning electro-magnet；1b：Y directions (downstream) scanning electro-magnet)

2：Ridged filter

3：Range shift unit

4：Annular collimator

5：Multi-diaphragm collimator (5_L：Vane plate；5_G：Blade group；)

6：Object block

10：Particle-beam therapeutic apparatus

20：Therapy planning device

21：Three-dimensional data generation unit

22：Irradiate condition setting unit

23：Control data generating unit

Asa：Scan axis (the 1st axis) (E of upstream scanning electro-magnet_As：It is assumed that axis)

Asb：The scan axis (the 2nd axis) of downstream scanning electro-magnet

CPa：1st datum mark

CPb：2nd datum mark

E_L：An end face opposite with vane plate

F_B：The beam (diffusion) of the particle beams

OL：The driving track of vane plate

P_I：Vane plate is (with E_LIt is adjacent) beam incidence surface side end face

P_L：The opposite face of the thickness direction of vane plate

PS：Through shape

P_X：Vane plate is (with E_LIt is adjacent) beam project surface side end face

ST：The scanning track of the particle beams

X_B：Beam axis (the E of the particle beams_X：Incide into the beam axis of the beam of multi-diaphragm collimator)

Variation involved by the digital representation embodiment of hundred.

Claims (12)

1. a kind of multi-diaphragm collimator, which configures in the beam trajectory of the charged particle beam after accelerated, and with The mode being consistent with irradiation object limits or is formed the irradiation field of the charged particle beam, which is characterized in that

The multi-diaphragm collimator includes：

Rows of blades, the rows of blades are arranged in a thickness direction in a manner of an end face of multiple vane plates is made to align；And

Vane plate driving mechanism, the vane plate driving mechanism is so that the beam axis of one end face to the charged particle beam leans on Close or remote from the mode of the beam axis of the charged particle beam, to respectively drive multiple vane plates,

Multiple vane plates are respectively provided with curved surface, which has different 2 radius of curvature due to the difference of direction, described Among 2 radius of curvature, central shaft i.e. the 1st axis of a radius of curvature by the 1st datum mark on the beam axis, another The central shaft of radius of curvature i.e. the 2nd axis on the beam axis by leaving the 2nd datum mark of the 1st datum mark.

2. multi-diaphragm collimator as described in claim 1, which is characterized in that

The curved surface with different 2 radius of curvature when direction is different is comparable to the bottom surface portions of multi-diaphragm collimator End face.

3. multi-diaphragm collimator as claimed in claim 1 or 2, which is characterized in that

The curved surface with different 2 radius of curvature when direction is different is comparable to the summit portion of multi-diaphragm collimator End face.

4. a kind of multi-diaphragm collimator, which configures in the beam trajectory of the charged particle beam after accelerated, and with The mode being consistent with irradiation object limits or is formed the irradiation field of the charged particle beam, which is characterized in that

The multi-diaphragm collimator includes：

Rows of blades, the rows of blades are arranged in a thickness direction in a manner of an end face of multiple vane plates is made to align；And

Vane plate driving mechanism, the vane plate driving mechanism is so that the beam axis of one end face to the charged particle beam leans on Close or remote from the mode of the beam axis of the charged particle beam, to respectively drive multiple vane plates,

Multiple vane plates are respectively formed as including to a part for the annulus generated as follows：

Make by centered on the 1st axis comprising the 1st datum mark and 2 articles of circular arcs that radius is different and vertical with the 1st axis The section that is surrounded of 2 articles of straight lines extended in face since the 1st datum mark, around direction it is different from the 1st axis the 2nd Axis rotates, and thus generates the annulus, and the 2nd axis is included in the 2nd base that the 1st datum mark is left on the beam axis On schedule.

5. a kind of particle-beam therapeutic apparatus, which is characterized in that including：

Mouth is irradiated, which is scanned the particle beams provided by accelerator using 2 different electromagnet of scanning direction, And it is irradiated；And

Multi-diaphragm collimator any one of Claims 1-4, which is configured at is irradiated by the irradiation mouth The particle beams in,

So that the 1st axis is consistent with the scan axis of an electromagnet in 2 electromagnet, and make the 2nd axis with it is another The consistent mode of the scan axis of one electromagnet, to configure the multi-diaphragm collimator.

6. particle-beam therapeutic apparatus as claimed in claim 5, which is characterized in that

The irradiation mouth irradiates the particle beams using spiral swing method, to expand irradiation field.

7. particle-beam therapeutic apparatus as claimed in claim 5, which is characterized in that

The irradiation mouth irradiates the particle beams using scanning method.

8. particle-beam therapeutic apparatus as claimed in claim 5, which is characterized in that

It is scanned using the deflection electromagnet for the direction deflection for making a beam axis in 2 electromagnet, also, will The beam axis for setting the 1st datum mark and the 2nd datum mark is set to incide into the beam of the beam of the multi-diaphragm collimator Axis.

9. a kind of therapy planning device, which is characterized in that including：

Three-dimensional data generation unit, the three-dimensional data generation unit generate three-dimensional data according to the image data of irradiation object；

Condition setting unit is irradiated, which sets irradiation condition based on the three-dimensional data generated；With And

Data generating unit is controlled, which is used for control pair based on set irradiation condition to generate The control data for the driving that the blade of the multi-diaphragm collimator in particle-beam therapeutic apparatus described in claim 5 is carried out,

The three-dimensional data generation unit is at least with the deflection angle of the beam centered on the 1st axis and with described The deflection angle of beam centered on 2nd axis, to generate the three-dimensional data.

10. a kind of therapy planning device, which is characterized in that including：

Three-dimensional data generation unit, the three-dimensional data generation unit generate three-dimensional data according to the image data of irradiation object；

Condition setting unit is irradiated, which sets irradiation condition based on the three-dimensional data generated；With And

Data generating unit is controlled, which is used for control pair based on set irradiation condition to generate The control data for the driving that the blade of the multi-diaphragm collimator in particle-beam therapeutic apparatus described in claim 6 is carried out,

The three-dimensional data generation unit is at least with the deflection angle of the beam centered on the 1st axis and with described The deflection angle of beam centered on 2nd axis, to generate the three-dimensional data.

11. a kind of therapy planning device, which is characterized in that including：

Three-dimensional data generation unit, the three-dimensional data generation unit generate three-dimensional data according to the image data of irradiation object；

Condition setting unit is irradiated, which sets irradiation condition based on the three-dimensional data generated；With And

Data generating unit is controlled, which is used for control pair based on set irradiation condition to generate The control data for the driving that the blade of the multi-diaphragm collimator in particle-beam therapeutic apparatus described in claim 7 is carried out,

The three-dimensional data generation unit is at least with the deflection angle of the beam centered on the 1st axis and with described The deflection angle of beam centered on 2nd axis, to generate the three-dimensional data.

12. a kind of therapy planning device, which is characterized in that including：

Three-dimensional data generation unit, the three-dimensional data generation unit generate three-dimensional data according to the image data of irradiation object；

Condition setting unit is irradiated, which sets irradiation condition based on the three-dimensional data generated；With And

Data generating unit is controlled, which is used for control pair based on set irradiation condition to generate The control data for the driving that the blade of the multi-diaphragm collimator in particle-beam therapeutic apparatus described in claim 8 is carried out,

The three-dimensional data generation unit is at least with the deflection angle of the beam centered on the 1st axis and with described The deflection angle of beam centered on 2nd axis, to generate the three-dimensional data.