CN104056229A

CN104056229A - Medicine for treating atrioventricular block and preparation method thereof

Info

Publication number: CN104056229A
Application number: CN201410286751.4A
Authority: CN
Inventors: 蔡合
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-25
Filing date: 2014-06-25
Publication date: 2014-09-24

Abstract

The invention discloses a medicine for treating atrioventricular block and a preparation method thereof, the medicine is prepared by rosewood heart wood, santal, lotus seed, Psoralea corylifolia, cassia twig, lotus leaf, bergamot, Chinese magnoliavine, ginger, fructus forsythia and wrinkled giant hyssop according to certain weight ratio. The medicine has the functions of tranquilizing by nourishing the heart, rectifying qi and dissipating binds, and clearing heat and detoxifying, and can be used for treating atrioventricular block with fast effectiveness, good curative effect and no recurrence.

Description

A kind of medicine for the treatment of atrioventricular block and preparation method thereof

Technical field

The present invention relates to a kind of medicine that is used for the treatment of atrioventricular block and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Normal heart impulsion at heart originates from sinuatrial node, sends impulsion, in conductive process with uniform frequency and rhythm, occur in the exciting conduction abnormalities between atrium and ventricle, can cause arrhythmia, make the heart can not normal contraction and pump blood, be called atrioventricular block.Atrioventricular block can occur in the different positions such as atrioventricular node, Xi Shi bundle and bundle branch.According to the difference of retarding degree, once can be divided into, two degree and third degree A-V blocks.At present, western medicine atrioventricular block poor effect, and long-term taking Western medicine has more side effect, and therefore, there is very large demand to the Chinese medicine of effective treatment atrioventricular block in people.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment atrioventricular block, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can effectively treat atrioventricular block.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Lignum Dalbergiae Odoriferae, Lignum Santali Albi, Semen Nelumbinis, Fructus Psoraleae, Ramulus Cinnamomi, Folium Nelumbinis, Fructus Citri Sarcodactylis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Polygonati Odorati, Concha Margaritifera, Pericarpium Citri Reticulatae Viride, Bulbus Lilii, Radix Ginseng Rubra, Eupolyphaga Seu Steleophaga, Bulbus Allii Macrostemonis, Radix Asparagi, Radix Polygalae, Fructus Jujubae medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating atrioventricular block.Wherein select Lignum Dalbergiae Odoriferae to be because its nature and flavor are pungent, temperature, enters liver, spleen channel, regulate the flow of vital energy, and hemostasis, clots absorbing, the function of analgesic therapy, controls haematemesis, spitting of blood, incised wound is hemorrhage, traumatic injury, carbuncle skin ulcer is swollen, lumbago, skelalgia of rheumatism, heart peratodynia.Select Lignum Santali Albi to be because its nature and flavor are pungent, temperature, enters spleen, stomach, lung meridian, regulates the flow of vital energy, and the function of stomach function regulating, controls trusted subordinate's pain, dysphagic vomiting, and chest and diaphragm does not relax.Select Semen Nelumbinis to be because its property sweet-puckery flavor is flat, enter the heart, spleen, kidney channel, nourish heart, kidney tonifying, spleen reinforcing, the function of astringing intestine to stop diarrhea, controls the dreaminess of sleeping night, seminal emission, stranguria with turbid discharge, chronic dysentery, diarrhea of deficiency type, married woman's bleeding not during menses.Select Fructus Psoraleae to be because its nature and flavor are pungent, temperature, enters kidney channel, has the function of reinforcing the kidney and supporting YANG, controls the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, and spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed, external curing vitiligo.Selecting Ramulus Cinnamomi is that temperature, enters bladder, the heart, lung meridian, has diaphoresis expelling pathogenic factors from muscles because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation, controls exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Folium Nelumbinis to be because its nature and flavor bitterness is flat, enter the heart, liver, spleen channel, have clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the function of hemostasis, controls diarrhea due to summer heat and dampness, dizzy, aqueous vapor edema, thunder-headache, spits blood, epistaxis, metrorrhagia, has blood in stool, puerperal blood faints.Select Fructus Citri Sarcodactylis, different name Fructus Citri Sarcodactylis, Bergamot, be because the arduous acid of its nature and flavor, and temperature, enters liver, stomach warp, regulates the flow of vital energy, and the function of reducing phlegm, treats for stomachache, coerce swollen, vomiting, dysphagic, phlegm retention cough with asthma, and relieving the effect of alcohol.Selecting Fructus Schisandrae Chinensis is that temperature, enters lung, kidney channel, astringes the lung because of its nature and flavor acid, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enters lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, opens the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Selecting Fructus Forsythiae is because its nature and flavor hardship, cool, enters the heart, liver, gallbladder meridian, has heat clearing away, removing toxic substances, eliminating stagnation, detumescence, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Herba Pogostemonis be because its nature and flavor pungent, tepor, enters lung, spleen, stomach warp, has fast gas, and in, ward off dirty, the function of damp eliminating, the heat-damp in summer that cures cold, cold and heat, headache, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, malaria, dysentery, halitosis.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst, controls calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warps, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy, spits blood, epistaxis, metrorrhagia.Selecting Pericarpium Citri Reticulatae Viride is that tepor, enters liver, gallbladder meridian, has soothing the liver dispelling the stagnated QI because of its nature and flavor toil, and the function of eliminating stagnation expectorant is controlled breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction piece.Select Bulbus Lilii to be because its property sweet and slightly bitter taste is flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, controls pulmonary tuberculosis chronic cough, cough and spit expectorant blood, and after calentura, waste heat is unclear, fidgets due to deficiency palpitation with fear, staring spells, beriberi edema.Selecting Radix Ginseng Rubra is that temperature, returns spleen, lung, heart channel, has strongly invigorating primordial QI because of sweet, the micro-hardship of its nature and flavor, and multiple arteries and veins is admittedly de-, and the function of nourishing qi to stop, controls weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis, heart failure, cardiogenic shock.It is salty because of its nature and flavor, cold, slightly poisonous selecting Eupolyphaga Seu Steleophaga.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select Bulbus Allii Macrostemonis to be because its nature and flavor are arduous, temperature, enters meridian of Hand-YANG MING, regulates the flow of vital energy, and the chest stuffiness relieving, activates yang, and the function of eliminating stagnation is controlled the thorough back of the body of obstruction of qi in the chest and cardialgia, and gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Selecting Radix Polygalae is that temperature, enters the heart, kidney channel, has the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm because of its nature and flavor toil, and the function of resolving depression, controls palpitation with fear, forgetful, nocturnal emission, and insomnia, cough ant phlegm, carbuncle skin ulcer is swollen.Select Fructus Jujubae to be because its nature and flavor are sweet, temperature, enters spleen, stomach warp, has spleen reinforcing stomach function regulating, and supplementing QI for promoting the production of body fluid adjusts battalion to defend, and separates the function of poison of drug, controls insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid deficiency, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Lignum Dalbergiae Odoriferae 3-9 gram of Lignum Santali Albi 6-10 gram of Semen Nelumbinis 5-15 gram

Fructus Psoraleae 6-10 gram of Ramulus Cinnamomi 4-10 gram of Folium Nelumbinis 10-14 gram

Fructus Citri Sarcodactylis 6-10 gram of Fructus Schisandrae Chinensis 6-10 gram of Rhizoma Zingiberis Recens 15-25 gram

Fructus Forsythiae 10-20 gram of Herba Pogostemonis 10-14 gram of Rhizoma Polygonati Odorati 10-14 gram

Concha Margaritifera 6-10 gram of Pericarpium Citri Reticulatae Viride 10-14 gram of Bulbus Lilii 5-15 gram

Radix Ginseng Rubra 3-9 gram of Eupolyphaga Seu Steleophaga 2-6 gram of Bulbus Allii Macrostemonis 6-10 gram

Radix Asparagi 5-15 gram of Radix Polygalae 5-15 gram of Fructus Jujubae 25-35 gram.

Preferable amount is

10 grams, 8 grams of Semen Nelumbinis of 6 grams of Lignum Santali Albis of Lignum Dalbergiae Odoriferae

12 grams, 5 grams of Folium Nelumbinis of 8 grams of Ramulus Cinnamomi of Fructus Psoraleae

20 grams, 8 grams of Rhizoma Zingiberis Recenss of 8 grams of Fructus Schisandrae Chinensis of Fructus Citri Sarcodactylis

12 grams of 12 grams of Rhizoma Polygonati Odorati of 15 grams of Herba Pogostemoniss of Fructus Forsythiae

10 grams of 12 grams of Bulbus Liliies of 8 grams of Pericarpium Citri Reticulatae Virides of Concha Margaritifera

8 grams of 4 grams of Bulbus Allii Macrostemonis of 6 grams of Eupolyphaga Seu Steleophagas of Radix Ginseng Rubra

30 grams, 10 grams of Fructus Jujubaes of 10 grams of Radix Polygalaes of Radix Asparagi.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Lignum Dalbergiae Odoriferae: after water logging, steam to appropriateness, pound sheet or flaking, dry;

2, Lignum Santali Albi: be soaked in water, pound sheet or split brokenly, dries;

3, Semen Nelumbinis: choose most impurity, or smash, remove the peel, go the heart to use;

4, Fructus Psoraleae: the clean impurity of winnowing with a dustpan, clean, dry;

5, Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

6, Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dries;

7, Fructus Citri Sarcodactylis: choose decontamination, after water spray profit, chopping, dries;

8, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;

9, Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;

10, Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;

11, Herba Pogostemonis: choose decontamination, remove undesirable root and old stem, first leaf is taken separately and put, stem water runs through, and cutting is dried, then with leaf and even;

12, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

13, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

14, Pericarpium Citri Reticulatae Viride: choose clean impurity, be soaked in water, pull out, run through, section, dries;

15, Bulbus Lilii: choose decontamination, black lobe, the dedust of winnowing with a dustpan bits;

16, Radix Ginseng Rubra: get crude drug, run through, shave, dry;

17, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

18, Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;

19, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;

20, Radix Polygalae: choose decontamination, cutting, sieve dedust bits;

21, Fructus Jujubae: choose clean impurity, dry.

Two, preparation

1, by the Lignum Dalbergiae Odoriferae of described weight, Lignum Santali Albi, Semen Nelumbinis, Fructus Psoraleae, Ramulus Cinnamomi, Folium Nelumbinis, Fructus Citri Sarcodactylis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Polygonati Odorati, Concha Margaritifera, Pericarpium Citri Reticulatae Viride, Bulbus Lilii, Radix Ginseng Rubra, Eupolyphaga Seu Steleophaga, Bulbus Allii Macrostemonis, Radix Asparagi, Radix Polygalae, Fructus Jujubae medicine, 8 times of amounts add water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time.

2, the medicinal residues of filtration are added water 6 times and measured, intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain decoction liquor for the second time.

3, merge twice decoction liquor, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 3 doses and takes.

Medicine of the present invention has tranquilizing by nourishing the heart, the eliminating stagnation of regulating the flow of vital energy, and the function of heat-clearing and toxic substances removing, is used for the treatment of atrioventricular block, short treating period, instant effect, has no side effect.

Detailed description of the invention

Further set forth below the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy atrioventricular block of the present invention

1, physical data

Accept atrioventricular block patient totally 34 examples for medical treatment.

2, diagnostic criteria

Clinical manifestation:

The patient of first degree A-V block is conventionally asymptomatic.

The patient of two degree I type atrioventricular blocks can be asymptomatic, mostly is cardiopalmus or the sensation of asystole if any symptom.

Its symptom of the patient of third degree A-V block is relevant to speed and the accompanying diseases of Ventricular Rate, patient can feel tired, weak, dizzy, faint, angina pectoris etc., during as Complicated by Heart Failure, have uncomfortable in chest, tachypnea and limitation of activity.

The atrioventricular block of above three types can transform along with the progress of the state of an illness.When one, second degree A-V block is when progress is for third degree A-V block suddenly, causes cerebral ischemia because Ventricular Rate slows down suddenly, may there is loss of consciousness, tic in patient, severe patient can cause sudden death.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day, early, middle and late respectively clothes 1 time, 6 days was a course for the treatment of, took continuously 6 courses for the treatment of.

4, efficacy assessment standard

Effective: atrioventricular block transference cure, observe half a year without bounce-back person;

Take a turn for the better: atrioventricular block symptom is obviously improved, and body constitution progressively strengthens;

Invalid: atrioventricular block symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy atrioventricular block patient of the present invention 34 examples, effective 27 examples of result, obvious effective rate is 79.41%, 5 examples that take a turn for the better, and improvement rate is 14.71%, invalid 2 examples, total effective rate is 94.12%.

Claims

1. a medicine for the treatment of atrioventricular block, is characterized in that: it is to be made up of the crude drug in following weight range:

2. medicine according to claim 1, wherein the consumption of each crude drug is:

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Lignum Dalbergiae Odoriferae: after water logging, steam to appropriateness, pound sheet or flaking, dry;

(2) Lignum Santali Albi: be soaked in water, pound sheet or split brokenly, dries;

(3) Semen Nelumbinis: choose most impurity, or smash, remove the peel, go the heart to use;

(4) Fructus Psoraleae: the clean impurity of winnowing with a dustpan, clean, dry;

(5) Ramulus Cinnamomi: water slightly soaks, pulls out, and moistening, to thoroughly, is cut into slices, and dries, and sieves anti-dandruff;

(6) Folium Nelumbinis: clean with water, cut off the base of a fruit and edge, shredding, dries;

(7) Fructus Citri Sarcodactylis: choose decontamination, after water spray profit, chopping, dries;

(8) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;

(9) Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;

(10) Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;

(11) Herba Pogostemonis: choose decontamination, remove undesirable root and old stem, first leaf is taken separately and put, stem water runs through, and cutting is dried, then with leaf and even;

(12) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

(13) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

(14) Pericarpium Citri Reticulatae Viride: choose clean impurity, be soaked in water, pull out, run through, section, dries;

(15) Bulbus Lilii: choose decontamination, black lobe, the dedust of winnowing with a dustpan bits;

(16) Radix Ginseng Rubra: get crude drug, run through, shave, dry;

(17) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(18) Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;

(19) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;

(20) Radix Polygalae: choose decontamination, cutting, sieve dedust bits;

(21) Fructus Jujubae: choose clean impurity, dry;

(2) preparation

(1) by the Lignum Dalbergiae Odoriferae of described weight, Lignum Santali Albi, Semen Nelumbinis, Fructus Psoraleae, Ramulus Cinnamomi, Folium Nelumbinis, Fructus Citri Sarcodactylis, Fructus Schisandrae Chinensis, Rhizoma Zingiberis Recens, Fructus Forsythiae, Herba Pogostemonis, Rhizoma Polygonati Odorati, Concha Margaritifera, Pericarpium Citri Reticulatae Viride, Bulbus Lilii, Radix Ginseng Rubra, Eupolyphaga Seu Steleophaga, Bulbus Allii Macrostemonis, Radix Asparagi, Radix Polygalae, Fructus Jujubae medicine, 8 times of amounts add water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, filter to obtain decoction liquor for the first time;

(2) medicinal residues of filtration are added water 6 times and measured, intense fire boils, then uses slow fire boiling 30 minutes, filters to obtain decoction liquor for the second time;

(3) merge twice decoction liquor, then with slow fire boiling 10 minutes and get final product.