CN103393926B - A kind of medicine for the treatment of chronic bronchitis and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine for the treatment of chronic bronchitis and preparation method thereof, it is mainly prepared from according to a certain weight ratio by Rhizoma Belamcandae, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Jujubae, Radix Ophiopogonis, Bulbus Lilii, medicine of the present invention has nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, promoting the circulation of QI eliminating phlegm, effect of warming spleen and stomach for dispelling cold, is used for the treatment of chronic bronchitis instant effect, good effect, cure rate is high.

Description

A kind of medicine for the treatment of chronic bronchitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic bronchitis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Chronic bronchitis is the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Clinically with cough, expectoration for cardinal symptom, annual continue 3 months, continuous more than 2 years or 2 years.The infection such as virus, mycoplasma, antibacterial is one of major reason of chronic bronchitis outbreak.Infective agent causes airway mucus to damage and chronic inflammatory disease.Viral infection is common with influenza virus, rhinovirus, adenovirus and respiratory syncytial virus.Antibacterial is often secondary to viral infection, and common causative is streptococcus pneumoniae, hemophilus influenza, moraxelle catarrhalis and staphylococcus.At present, because Western medicine cannot rapid, effective treatment chronic bronchitis, and have more side effect, therefore, there is very large demand to the Chinese medicine of rapid, effective treatment chronic bronchitis in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment chronic bronchitis, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating chronic bronchitis.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Rhizoma Belamcandae, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Jujubae, Radix Ophiopogonis, Bulbus Lilii, Semen Armeniacae Amarum, Radix Polygalae, Fructus Perillae, Semen Sinapis Albae, the Radix Astragali, Semen Raphani medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat chronic bronchitis.Wherein select Rhizoma Belamcandae to be because its nature and flavor are bitter, cold, poisonous, enter lung, Liver Channel, have pathogenic fire reducing, removing toxic substances, loose blood, the function of expectorant, controls sore throat pharyngalgia, cough with dyspnea, accumulation and obstruction of sputum, scrofula tuberculosis, malaria with splenomegaly, women's amenorrhea, carbuncle sore tumefacting virus.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select be because its property sweet and slightly bitter taste Radix Ophiopogonis, cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, clear away heart-fire relieving restlessness, and the function of reinforcing stomach reg fluid controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, and clearly yearningly, calentura Tianjin is hindered, dry mouth and throat, constipation.Select Bulbus Lilii to be because its property sweet and slightly bitter taste, flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, control pulmonary tuberculosis chronic cough, cough and spit expectorant blood, after calentura, waste heat is unclear, and fidgets due to deficiency is palpitated with fear, staring spells, beriberi edema.Semen Armeniacae Amarum is selected to be that temperature, poisonous, enter lung, large intestine channel, have expelling phlegm for arresting cough, relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation because its nature and flavor are bitter.Select Radix Polygalae to be because its nature and flavor toil, temperature, enter the heart, kidney channel, have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, the function of resolving depression, controls palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, and carbuncle skin ulcer swells.Fructus Perillae is selected to be that temperature, enter lung, large intestine channel, have the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, the function of wide intestinal, controls cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation because its nature and flavor are pungent.Select Semen Sinapis Albae to be that temperature, enters lung, stomach warp, have promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain because its nature and flavor are pungent, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Semen Raphani is selected to be because its property acrid-sweet flavor, flat, enter lung, stomach warp, have therapeutic method to keep the adverse QI flowing downwards Dingchuan, the function eliminated indigestion and phlegm, control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy after dysentery.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Rhizoma Belamcandae 10-20 gram of Bulbus Fritillariae Cirrhosae 5-10 gram of Radix Glycyrrhizae 5-15 gram

Fructus Jujubae 15-25 gram of Radix Ophiopogonis 15-25 gram of Bulbus Lilii 20-30 gram

Semen Armeniacae Amarum 20-30 gram Radix Polygalae 20-30 gram Fructus Perillae 20-30 gram

Semen Sinapis Albae 20-30 gram of Radix Astragali 10-20 gram of Semen Raphani 15-25 gram

Preferable amount is

10 grams, Rhizoma Belamcandae 15 grams of Bulbus Fritillariae Cirrhosaes 6 grams of Radix Glycyrrhizaes

Fructus Jujubae 20 grams of Bulbus Liliies, 20 grams of Radix Ophiopogonis 25 grams

Semen Armeniacae Amarum 25 grams of Radix Polygalaes 25 grams of Fructus Perillaes 25 grams

Semen Sinapis Albae 25 grams of Radixs Astragali 15 grams of Semen Raphanis 20 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Rhizoma Belamcandae: pick decontamination, water is cleaned, and slightly soaks, pulls out, run through, and section, dries, and sieve goes must, consider to be worth doing;

2, Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;

3, Radix Glycyrrhizae: pick decontamination, cleans, and when being soaked in water saturating to eighty per cant, pulling out, runs through, section, airing;

4, Fructus Jujubae: pick clean impurity, dry;

5, Radix Ophiopogonis: pick clean impurity, be soaked in water, pull out, pump the heart after running through, then clean dry;

6, Bulbus Lilii: pick decontamination, black lobe, ash disposal of winnowing with a dustpan is considered to be worth doing;

7, Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, the Pi Wei that waits purses up and pulls out, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

8, Radix Polygalae: pick decontamination, cutting, sieve dedust bits;

9, Fructus Perillae: dedust of winnowing with a dustpan is considered to be worth doing, cleans, dries;

10, Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;

11, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

12, Semen Raphani: decontamination of winnowing with a dustpan, rinses earth, pulls out, dries, and the used time smashs to pieces.

Two, prepare

1, the Rhizoma Belamcandae of described weight, Bulbus Fritillariae Cirrhosae, Radix Glycyrrhizae, Fructus Jujubae, Radix Ophiopogonis, Bulbus Lilii, Semen Armeniacae Amarum, Radix Polygalae, Fructus Perillae, Semen Sinapis Albae, the Radix Astragali, Semen Raphani medicine are decocted with water secondary, add water 6 times amount for the first time, soak after 180 minutes, intense fire decocts 15 minutes, use slow fire boiling again 20 minutes, filter, obtain first time decoction liquor.

2, add water the medicinal residues of filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 15 minutes, filters to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, pours in container by decoction medicinal liquid, is divided into 3 doses and takes.

Medicine of the present invention has nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, effect of pathogenic fire reducing, and treatment chronic bronchitis instant effect, short treating period, do not recur.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 20, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 10, wherein one group is normal amount toxicity test, another group is super quantity toxicity test, and normal amount group is 10ml/kg, and excess group is 20ml/kg, administering mode is administration by gavage administration, every day 2 times, be used in conjunction 7 days, observe administration reaction every day, result of the test shows that two groups of families exempt from diet activity normally, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient 210 example for medical treatment, male patient 140 example, female patient 70 example.

2, diagnostic criteria

Symptom: onset is slow, and the course of disease is long, and acute attack causes aggravation repeatedly.

(1) cough: general daystart cough is main, has apasm of coughing and expectoration during sleep.Along with PD, cough is not healed all the year round.

(2) expectoration: be generally white slimy or serosity spumescence, occasionally can be with blood.Early morning, expectoration was more, and back river position of getting up variation can stimulate expectoration.

(3) breathe hard or pant: the obvious person that pants often is called asthmatic bronchitis, part may merge bronchial asthma.If breathe hard after can showing as activity during emphysema.

Clinically with cough, expectoration for cardinal symptom, or with panting, annual morbidity continues 3 months, and continuous more than 2 years or 2 years.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, every day is early, middle and late respectively takes 1 time, within 15 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: transference cure, body constitution recovers normal, observes 1 year without recidivist;

Take a turn for the better: the state of an illness is clearly better, and body constitution is progressively recovered.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy chronic bronchitis patient 210 example of the present invention, effective 200 examples of result, obvious effective rate is 95.24%, and take a turn for the better 6 examples, and improvement rate is 2.86%, and invalid 4 examples, total effective rate is 98.1%.

Claims (2)

1. treat a medicine for chronic bronchitis, it is characterized in that: it is made up of the crude drug in following weight range:

Rhizoma Belamcandae 10-20 gram of Bulbus Fritillariae Cirrhosae 5-10 gram of Radix Glycyrrhizae 5-15 gram

Fructus Jujubae 15-25 gram of Radix Ophiopogonis 15-25 gram of Bulbus Lilii 20-30 gram

Semen Armeniacae Amarum 20-30 gram Radix Polygalae 20-30 gram Fructus Perillae 20-30 gram

Semen Sinapis Albae 20-30 gram of Radix Astragali 10-20 gram of Semen Raphani 15-25 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

10 grams, Rhizoma Belamcandae 15 grams of Bulbus Fritillariae Cirrhosaes 6 grams of Radix Glycyrrhizaes

Fructus Jujubae 20 grams of Bulbus Liliies, 20 grams of Radix Ophiopogonis 25 grams

Semen Armeniacae Amarum 25 grams of Radix Polygalaes 25 grams of Fructus Perillaes 25 grams

Semen Sinapis Albae 25 grams of Radixs Astragali 15 grams of Semen Raphanis 20 grams.