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CL2013000784A1 - Compuestos derivados de (n,2-difenil)- o (2-fenil-n-piridin)- 2-[(pirimidin-5iloxi)metil]ciclopopanocarboxamida, antagonista del receptor de orexina; composicion farmaceutica; que los comprende; y su uso en transtorno del sueño tal como insomnio. (pct fase nacional) - Google Patents

Compuestos derivados de (n,2-difenil)- o (2-fenil-n-piridin)- 2-[(pirimidin-5iloxi)metil]ciclopopanocarboxamida, antagonista del receptor de orexina; composicion farmaceutica; que los comprende; y su uso en transtorno del sueño tal como insomnio. (pct fase nacional)

Info

Publication number
CL2013000784A1
CL2013000784A1 CL2013000784A CL2013000784A CL2013000784A1 CL 2013000784 A1 CL2013000784 A1 CL 2013000784A1 CL 2013000784 A CL2013000784 A CL 2013000784A CL 2013000784 A CL2013000784 A CL 2013000784A CL 2013000784 A1 CL2013000784 A1 CL 2013000784A1
Authority
CL
Chile
Prior art keywords
cyclopopanecarboxamide
insomnia
pyrimidin
pyridin
diphenyl
Prior art date
Application number
CL2013000784A
Other languages
English (en)
Inventor
Taro Terauchi
Ayumi Takemura
Takashi Doko
Yu Yoshida
Toshiaki Tanaka
Keiichi Sorimachi
Yoshimitsu Naoe
Carsten Beuckmann
Yuji Kazuta
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of CL2013000784A1 publication Critical patent/CL2013000784A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos derivados de (n,2-difenil)- o (2-fenil-n-piridin)-2-[(pirimidin-5iloxi)metil]ciclopopanocarboxamida, antagonistas del receptor de orexina; composición farmacéutica; y su uso para tratar un trastorno del sueño, tal como insomnio.
CL2013000784A 2010-09-22 2013-03-21 Compuestos derivados de (n,2-difenil)- o (2-fenil-n-piridin)- 2-[(pirimidin-5iloxi)metil]ciclopopanocarboxamida, antagonista del receptor de orexina; composicion farmaceutica; que los comprende; y su uso en transtorno del sueño tal como insomnio. (pct fase nacional) CL2013000784A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38534210P 2010-09-22 2010-09-22
JP2010211629 2010-09-22

Publications (1)

Publication Number Publication Date
CL2013000784A1 true CL2013000784A1 (es) 2013-07-05

Family

ID=45873858

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013000784A CL2013000784A1 (es) 2010-09-22 2013-03-21 Compuestos derivados de (n,2-difenil)- o (2-fenil-n-piridin)- 2-[(pirimidin-5iloxi)metil]ciclopopanocarboxamida, antagonista del receptor de orexina; composicion farmaceutica; que los comprende; y su uso en transtorno del sueño tal como insomnio. (pct fase nacional)

Country Status (28)

Country Link
US (1) US8268848B2 (es)
EP (1) EP2626350B1 (es)
JP (1) JP4944286B1 (es)
KR (1) KR101458007B1 (es)
CN (1) CN103153963B (es)
AR (1) AR083060A1 (es)
AU (1) AU2011304285B2 (es)
BR (1) BR112013006594B1 (es)
CA (1) CA2811895C (es)
CL (1) CL2013000784A1 (es)
DK (1) DK2626350T3 (es)
ES (1) ES2540851T3 (es)
IL (1) IL225437A (es)
JO (1) JO2990B1 (es)
MA (1) MA34609B1 (es)
MX (1) MX2013003218A (es)
MY (1) MY160969A (es)
NZ (1) NZ609313A (es)
PE (1) PE20131162A1 (es)
PL (1) PL2626350T3 (es)
PT (1) PT2626350E (es)
RS (1) RS54101B1 (es)
RU (1) RU2571414C2 (es)
SG (1) SG188585A1 (es)
SI (1) SI2626350T1 (es)
TW (1) TWI516484B (es)
UA (1) UA108510C2 (es)
WO (1) WO2012039371A1 (es)

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Publication number Publication date
PE20131162A1 (es) 2013-10-19
SI2626350T1 (sl) 2015-09-30
DK2626350T3 (en) 2015-06-29
AU2011304285B2 (en) 2015-01-29
RU2571414C2 (ru) 2015-12-20
EP2626350B1 (en) 2015-04-15
KR101458007B1 (ko) 2014-11-04
AU2011304285A1 (en) 2013-05-16
US8268848B2 (en) 2012-09-18
NZ609313A (en) 2014-05-30
JP4944286B1 (ja) 2012-05-30
RS54101B1 (en) 2015-10-30
US20120095031A1 (en) 2012-04-19
IL225437A0 (en) 2013-06-27
BR112013006594A2 (pt) 2016-06-21
MA34609B1 (fr) 2013-10-02
MY160969A (en) 2017-03-31
JO2990B1 (ar) 2016-09-05
BR112013006594B1 (pt) 2021-08-17
MX2013003218A (es) 2013-06-28
RU2013117464A (ru) 2014-10-27
EP2626350A1 (en) 2013-08-14
CN103153963A (zh) 2013-06-12
IL225437A (en) 2015-05-31
SG188585A1 (en) 2013-04-30
PT2626350E (pt) 2015-08-03
TWI516484B (zh) 2016-01-11
EP2626350A4 (en) 2014-02-12
UA108510C2 (en) 2015-05-12
TW201305129A (zh) 2013-02-01
CN103153963B (zh) 2014-12-24
CA2811895A1 (en) 2012-03-29
CA2811895C (en) 2015-12-08
WO2012039371A1 (ja) 2012-03-29
KR20130097776A (ko) 2013-09-03
ES2540851T3 (es) 2015-07-14
AR083060A1 (es) 2013-01-30
JPWO2012039371A1 (ja) 2014-02-03
PL2626350T3 (pl) 2015-08-31

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