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BRPI0507984B8 - composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamífero, para melhorar a resistência de insulina em um mamífero e para prevenir ou tratar doenças circulatórias em um mamífero, e, uso do composto - Google Patents

composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamífero, para melhorar a resistência de insulina em um mamífero e para prevenir ou tratar doenças circulatórias em um mamífero, e, uso do composto

Info

Publication number
BRPI0507984B8
BRPI0507984B8 BRPI0507984A BRPI0507984A BRPI0507984B8 BR PI0507984 B8 BRPI0507984 B8 BR PI0507984B8 BR PI0507984 A BRPI0507984 A BR PI0507984A BR PI0507984 A BRPI0507984 A BR PI0507984A BR PI0507984 B8 BRPI0507984 B8 BR PI0507984B8
Authority
BR
Brazil
Prior art keywords
compound
mammal
salt
preventing
methods
Prior art date
Application number
BRPI0507984A
Other languages
English (en)
Inventor
Kuroita Takanobu
Sakamoto Hiroki
Ojima Mami
Original Assignee
Darwin Prestacao De Servicos De Marketing Ltda
Takeda Pharmaceuticals Co
Takeda Pharmaceuticals Int Ag
Hypera S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34858222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0507984(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Darwin Prestacao De Servicos De Marketing Ltda, Takeda Pharmaceuticals Co, Takeda Pharmaceuticals Int Ag, Hypera S A filed Critical Darwin Prestacao De Servicos De Marketing Ltda
Priority to BR122012009489A priority Critical patent/BR122012009489B8/pt
Publication of BRPI0507984A publication Critical patent/BRPI0507984A/pt
Publication of BRPI0507984B1 publication Critical patent/BRPI0507984B1/pt
Publication of BRPI0507984B8 publication Critical patent/BRPI0507984B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamífero, para melhorar a resistência de insulina em um mamífero e para prevenir ou tratar doenças circulatórias em um mamífero, e, uso do composto" a presente invenção está relacionada a um composto representado pela fórmula (i) onde r^ 1^ é um grupo representado pelas fórmulas onde r^ 2^, r^ 3^, r^ 4^, r^ 5^, r^ 6^, r^ 7^ e r^ 8^ são cada um independentemente um átompo de hidrogênio ou um c~ 1~-~ 6~ alquila, ou um sal do mesmo. o composto da presente invenção é útil como um agente para profilaxia ou para tratamento de doenças circulatórias tais como hipertensão e similares, e doenças metabólicas tais como diabetes e similares.
BRPI0507984A 2004-02-25 2005-02-23 composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamífero, para melhorar a resistência de insulina em um mamífero e para prevenir ou tratar doenças circulatórias em um mamífero, e, uso do composto BRPI0507984B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122012009489A BR122012009489B8 (pt) 2004-02-25 2005-02-23 processo para produzir 2-etóxi-1-{[2’-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2004048928 2004-02-25
JP2004-048928 2004-02-25
US11/031,057 US7157584B2 (en) 2004-02-25 2005-01-07 Benzimidazole derivative and use thereof
US11/031,057 2005-01-07
PCT/JP2005/003422 WO2005080384A2 (en) 2004-02-25 2005-02-23 Benzimidazole derivative and use as aii receptor antagonist

Publications (3)

Publication Number Publication Date
BRPI0507984A BRPI0507984A (pt) 2007-07-24
BRPI0507984B1 BRPI0507984B1 (pt) 2018-07-03
BRPI0507984B8 true BRPI0507984B8 (pt) 2023-03-21

Family

ID=34858222

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122012009489A BR122012009489B8 (pt) 2004-02-25 2005-02-23 processo para produzir 2-etóxi-1-{[2’-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso
BRPI0507984A BRPI0507984B8 (pt) 2004-02-25 2005-02-23 composto ou um sal do mesmo, processo para produzir um composto, medicamento, métodos para antagonizar angiotensina ii em um mamífero, para melhorar a resistência de insulina em um mamífero e para prevenir ou tratar doenças circulatórias em um mamífero, e, uso do composto

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122012009489A BR122012009489B8 (pt) 2004-02-25 2005-02-23 processo para produzir 2-etóxi-1-{[2’-(5-oxo-4,5-diidro-1,2,4-oxadiazol-3-il)bifenil-4-il]metil}-1h-benzimidazol-7-carboxilato de (5-metil-2-oxo-1,3-dioxol-4-il)metila ou um sal do mesmo, composição farmacéutica, e, uso

Country Status (34)

Country Link
US (3) US7157584B2 (pt)
EP (3) EP2119715B1 (pt)
JP (2) JP4256852B2 (pt)
KR (1) KR101080029B1 (pt)
CN (2) CN101381366B (pt)
AR (2) AR047972A1 (pt)
AT (2) ATE370136T1 (pt)
AU (1) AU2005214271B8 (pt)
BE (1) BE2012C025I2 (pt)
BR (2) BR122012009489B8 (pt)
CA (1) CA2557538C (pt)
CY (5) CY1107008T1 (pt)
DE (3) DE602005016162D1 (pt)
DK (3) DK1857457T3 (pt)
ES (3) ES2293552T3 (pt)
HK (2) HK1098472A1 (pt)
HR (3) HRP20070510T3 (pt)
HU (1) HUS1200008I1 (pt)
IL (1) IL177533A (pt)
LU (1) LU91962I2 (pt)
MA (1) MA28478B1 (pt)
ME (2) ME01643B (pt)
MY (1) MY142807A (pt)
NL (1) NL300802I2 (pt)
NO (2) NO332344B1 (pt)
NZ (1) NZ549755A (pt)
PL (3) PL2119715T3 (pt)
PT (3) PT1718641E (pt)
RS (3) RS52376B (pt)
RU (2) RU2501798C2 (pt)
SI (3) SI2119715T1 (pt)
TW (1) TWI336702B (pt)
WO (1) WO2005080384A2 (pt)
ZA (1) ZA200607241B (pt)

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