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BR9913553A - Formulação de ranolazina de liberação sustentada - Google Patents

Formulação de ranolazina de liberação sustentada

Info

Publication number
BR9913553A
BR9913553A BR9913553-1A BR9913553A BR9913553A BR 9913553 A BR9913553 A BR 9913553A BR 9913553 A BR9913553 A BR 9913553A BR 9913553 A BR9913553 A BR 9913553A
Authority
BR
Brazil
Prior art keywords
ranolazine
sustained release
release formulation
formation
aqueous medium
Prior art date
Application number
BR9913553-1A
Other languages
English (en)
Inventor
Andrew A Wolff
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26796494&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9913553(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of BR9913553A publication Critical patent/BR9913553A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

"FORMULAçãO DE RANOLAZINA DE LIBERAçãO SUSTENTADA". Uma formulação de ranolazina de contém uma mistura íntima de ranolazina e um aglutinante dependente de pH parcialmente neutralizado, para a formação de um filme, que é praticamente insolúvel em um meio aquoso com pH abaixo de 4, 5 e solúvel em um meio aquoso com pH acima de 4,5 . A formulação é adequada para uma administração duas vezes ao dia de ranolazina, e é útil para o controle da taxa de dissolução de ranolazina, e para manter os níveis de ranolazina de plasma humano entre 550 e 7500 ng base/mL.
BR9913553-1A 1998-09-10 1999-09-09 Formulação de ranolazina de liberação sustentada BR9913553A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9980498P 1998-09-10 1998-09-10
US09/321,522 US6303607B1 (en) 1998-09-10 1999-05-27 Method for administering a sustained release ranolanolazine formulation
PCT/US1999/020968 WO2000013687A2 (en) 1998-09-10 1999-09-09 Sustained release ranolazine formulations

Publications (1)

Publication Number Publication Date
BR9913553A true BR9913553A (pt) 2001-10-23

Family

ID=26796494

Family Applications (2)

Application Number Title Priority Date Filing Date
BR9913626-0A BR9913626A (pt) 1998-09-10 1999-09-09 Formulações de ranolazina de liberação contìnua
BR9913553-1A BR9913553A (pt) 1998-09-10 1999-09-09 Formulação de ranolazina de liberação sustentada

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR9913626-0A BR9913626A (pt) 1998-09-10 1999-09-09 Formulações de ranolazina de liberação contìnua

Country Status (33)

Country Link
US (14) US6303607B1 (pt)
EP (3) EP1527779A1 (pt)
JP (2) JP3745621B2 (pt)
KR (1) KR100475759B1 (pt)
CN (2) CN1193757C (pt)
AR (3) AR022085A1 (pt)
AT (2) ATE285774T1 (pt)
AU (4) AU760435B2 (pt)
BR (2) BR9913626A (pt)
CA (2) CA2342390C (pt)
CY (1) CY2008020I1 (pt)
CZ (2) CZ301375B6 (pt)
DE (3) DE122008000065I1 (pt)
DK (2) DK1109558T3 (pt)
ES (2) ES2234302T3 (pt)
FR (1) FR09C0001I2 (pt)
GE (1) GEP20053420B (pt)
HK (2) HK1040060A1 (pt)
HU (2) HU224215B1 (pt)
IL (6) IL141893A0 (pt)
LU (1) LU91504I2 (pt)
MX (2) MXPA01002598A (pt)
NL (1) NL300371I2 (pt)
NO (4) NO319434B1 (pt)
NZ (2) NZ510384A (pt)
PL (3) PL196668B1 (pt)
PT (2) PT1096937E (pt)
RU (2) RU2214233C2 (pt)
SI (2) SI1096937T1 (pt)
TR (2) TR200101261T2 (pt)
TW (1) TWI241911B (pt)
UA (2) UA67793C2 (pt)
WO (2) WO2000013686A2 (pt)

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Also Published As

Publication number Publication date
NO20011192L (no) 2001-04-30
US20020004506A1 (en) 2002-01-10
NZ510386A (en) 2003-08-29
KR100475759B1 (ko) 2005-03-10
US20020090396A1 (en) 2002-07-11
EP1527779A1 (en) 2005-05-04
HUP0103844A3 (en) 2002-11-28
US20040029890A1 (en) 2004-02-12
CN1193757C (zh) 2005-03-23
HUP0103844A2 (hu) 2002-04-29
WO2000013686A3 (en) 2000-07-06
WO2000013687A3 (en) 2000-06-29
TR200101262T2 (tr) 2001-12-21
US20030099705A1 (en) 2003-05-29
HK1040060A1 (en) 2002-05-24
DK1096937T3 (da) 2005-05-09
ES2177346T3 (es) 2002-12-01
EP1096937B1 (en) 2004-12-29
US6369062B1 (en) 2002-04-09
US6864258B2 (en) 2005-03-08
AR053440A2 (es) 2007-05-09
AU2008207703A1 (en) 2008-09-25
US20050153982A1 (en) 2005-07-14
FR09C0001I2 (pt) 2009-12-18
HK1044284B (zh) 2005-07-15
JP2006096757A (ja) 2006-04-13
PL347073A1 (en) 2002-03-11
WO2000013686A2 (en) 2000-03-16
ATE217794T1 (de) 2002-06-15
EP1096937A2 (en) 2001-05-09
US20050059667A1 (en) 2005-03-17
US6620814B2 (en) 2003-09-16
PT1109558E (pt) 2002-10-31
CA2343376A1 (en) 2000-03-16
ES2234302T3 (es) 2005-06-16
GEP20053420B (en) 2005-01-25
BR9913626A (pt) 2001-12-04
UA67793C2 (uk) 2004-07-15
US6303607B1 (en) 2001-10-16
CN1211086C (zh) 2005-07-20
JP3745621B2 (ja) 2006-02-15
US20030166659A1 (en) 2003-09-04
IL141892A (en) 2006-08-20
HU224215B1 (hu) 2005-06-28
PL348249A1 (en) 2002-05-20
WO2000013687A2 (en) 2000-03-16
NO20054324L (no) 2001-04-30
CN1321088A (zh) 2001-11-07
HUP0104088A3 (en) 2002-12-28
DE122008000065I1 (de) 2009-04-09
AU6142599A (en) 2000-03-27
IL141893A0 (en) 2002-03-10
CZ301375B6 (cs) 2010-02-03
DE69922964D1 (de) 2005-02-03
CY2008020I2 (el) 2010-07-28
EP1109558A2 (en) 2001-06-27
NL300371I1 (nl) 2009-02-02
IL141893A (en) 2008-08-07
US6852724B2 (en) 2005-02-08
PT1096937E (pt) 2005-04-29
DE69922964T2 (de) 2005-12-08
NO2009005I1 (no) 2009-03-16
SI1109558T1 (en) 2002-10-31
UA75027C2 (uk) 2006-03-15
NO20011191D0 (no) 2001-03-08
US20060217397A1 (en) 2006-09-28
PL196668B1 (pl) 2008-01-31
HK1044284A1 (en) 2002-10-18
NO20011192D0 (no) 2001-03-08
IL180864A0 (en) 2007-07-04
JP2002524416A (ja) 2002-08-06
NL300371I2 (nl) 2009-10-01
NO320986B1 (no) 2006-02-20
IL141892A0 (en) 2002-03-10
AR022085A1 (es) 2002-09-04
TR200101261T2 (tr) 2002-05-21
MXPA01002598A (es) 2002-04-08
MXPA01002599A (es) 2005-02-17
DE69901570D1 (de) 2002-06-27
NZ510384A (en) 2002-10-25
US20030100566A1 (en) 2003-05-29
LU91504I9 (pt) 2019-01-02
SI1096937T1 (en) 2005-04-30
DK1109558T3 (da) 2002-08-26
KR20010089874A (ko) 2001-10-12
US20040097514A1 (en) 2004-05-20
US6617328B2 (en) 2003-09-09
AU744071B2 (en) 2002-02-14
CA2342390A1 (en) 2000-03-16
IL175371A0 (en) 2006-09-05
ATE285774T1 (de) 2005-01-15
US6562826B1 (en) 2003-05-13
CZ2001880A3 (cs) 2001-08-15
CA2342390C (en) 2006-08-29
LU91504I2 (fr) 2009-02-03
RU2207856C2 (ru) 2003-07-10
AU6036499A (en) 2000-03-27
DE69901570T2 (de) 2003-01-09
EP1096937B9 (en) 2007-02-28
CA2343376C (en) 2007-01-09
NO2009005I2 (pt) 2010-06-28
FR09C0001I1 (pt) 2009-02-27
AR052921A1 (es) 2007-04-11
AU760435B2 (en) 2003-05-15
TWI241911B (en) 2005-10-21
CY2008020I1 (el) 2010-07-28
PL196263B1 (pl) 2007-12-31
NO319434B1 (no) 2005-08-15
AU2008207707A1 (en) 2008-09-25
RU2214233C2 (ru) 2003-10-20
CZ301341B6 (cs) 2010-01-20
US20060147521A1 (en) 2006-07-06
CN1354665A (zh) 2002-06-19
CZ2001879A3 (cs) 2001-08-15
US6503911B2 (en) 2003-01-07
PL202207B1 (pl) 2009-06-30
NO20011191L (no) 2001-04-30
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US6525057B2 (en) 2003-02-25

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