[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BR9707839A - Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação - Google Patents

Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação

Info

Publication number
BR9707839A
BR9707839A BR9707839A BR9707839A BR9707839A BR 9707839 A BR9707839 A BR 9707839A BR 9707839 A BR9707839 A BR 9707839A BR 9707839 A BR9707839 A BR 9707839A BR 9707839 A BR9707839 A BR 9707839A
Authority
BR
Brazil
Prior art keywords
primidas
primido
compounds
preparation
application
Prior art date
Application number
BR9707839A
Other languages
English (en)
Inventor
Frank Dr Himmelsbach
Georg Dr Dahmann
Rueden Thomas Dr Von
Thomas Dr Metz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of BR9707839A publication Critical patent/BR9707839A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR9707839A 1996-03-06 1997-03-03 Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação BR9707839A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608588A DE19608588A1 (de) 1996-03-06 1996-03-06 Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1997/001047 WO1997032880A1 (de) 1996-03-06 1997-03-03 PYRIMIDO[5,4-d]PYRIMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG

Publications (1)

Publication Number Publication Date
BR9707839A true BR9707839A (pt) 1999-07-27

Family

ID=7787345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707839A BR9707839A (pt) 1996-03-06 1997-03-03 Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação

Country Status (30)

Country Link
US (1) US5821240A (pt)
EP (1) EP0888351B1 (pt)
JP (1) JP2000506151A (pt)
KR (1) KR19990087504A (pt)
CN (1) CN1064362C (pt)
AR (1) AR006108A1 (pt)
AT (1) ATE252101T1 (pt)
AU (1) AU730376B2 (pt)
BG (1) BG63163B1 (pt)
BR (1) BR9707839A (pt)
CA (1) CA2248720A1 (pt)
CO (1) CO4650043A1 (pt)
CZ (1) CZ281598A3 (pt)
DE (2) DE19608588A1 (pt)
EE (1) EE9800278A (pt)
HK (1) HK1018450A1 (pt)
HU (1) HUP9902049A3 (pt)
IL (1) IL125342A0 (pt)
MX (1) MX9807073A (pt)
NO (1) NO311522B1 (pt)
NZ (1) NZ331545A (pt)
PL (1) PL328719A1 (pt)
RU (1) RU2195461C2 (pt)
SK (1) SK120898A3 (pt)
TR (1) TR199801755T2 (pt)
TW (1) TW454008B (pt)
UA (1) UA54421C2 (pt)
UY (1) UY24474A1 (pt)
WO (1) WO1997032880A1 (pt)
ZA (1) ZA971887B (pt)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2194181T3 (es) 1996-02-13 2003-11-16 Astrazeneca Ab Derivados de quinazolina como inhibidores de vegf.
CA2244897C (en) 1996-03-05 2006-04-11 Zeneca Limited 4-anilinoquinazoline derivatives
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
SI1244647T1 (sl) 1999-11-05 2006-10-31 Astrazeneca Ab Kinazolinski derivati kot VEGF inhibitorji
EP1170011A1 (en) * 2000-07-06 2002-01-09 Boehringer Ingelheim International GmbH Novel use of inhibitors of the epidermal growth factor receptor
DE10115921A1 (de) 2001-03-30 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
EP1300146A1 (en) * 2001-10-03 2003-04-09 Boehringer Ingelheim International GmbH Pharmaceutical composition for the treatment of animal mammary tumors
WO2003055858A1 (fr) * 2001-12-27 2003-07-10 Toray Fine Chemicals Co., Ltd. Processus de production de derive heterocyclique sature azote 1-alcoxycarbonyle
EP1608652A1 (en) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
DE602004012891T2 (de) * 2003-12-18 2009-04-09 Janssen Pharmaceutica N.V. Pyrido- und pyrimidopyrimidinderivate als anti-proliferative mittel
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
JO3088B1 (ar) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
KR101139038B1 (ko) * 2005-06-28 2012-05-02 삼성전자주식회사 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터
BRPI0714211B8 (pt) 2006-07-13 2021-05-25 Janssen Pharmaceutica Nv derivados de mtki quinazolina, sua utilização e composição farmacêutica que os compreende
DK2170827T3 (da) * 2007-06-21 2013-11-18 Janssen Pharmaceutica Nv Indolin-2-oner og aza-indolin-2-oner
GB0713602D0 (en) * 2007-07-12 2007-08-22 Syngenta Participations Ag Chemical compounds
WO2009016132A1 (en) 2007-07-27 2009-02-05 Janssen Pharmaceutica Nv Pyrrolopyrimidines
JP2009215259A (ja) * 2008-03-12 2009-09-24 Ube Ind Ltd 3−ハロゲノ−4−ヒドロカルビルオキシニトロベンゼン化合物の製造方法
TW201014860A (en) 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
MX2011004824A (es) 2008-11-07 2012-01-12 Triact Therapeutics Inc Uso de derivados de butano catecólico en terapia contra el cáncer.
CA2752265A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
EP2400990A2 (en) 2009-02-26 2012-01-04 OSI Pharmaceuticals, LLC In situ methods for monitoring the emt status of tumor cells in vivo
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
JP2012519282A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US20120064072A1 (en) 2009-03-18 2012-03-15 Maryland Franklin Combination Cancer Therapy Comprising Administration of an EGFR Inhibitor and an IGF-1R Inhibitor
CA2780875A1 (en) 2009-11-13 2011-05-19 Pangaea Biotech, S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
EP2468883A1 (en) 2010-12-22 2012-06-27 Pangaea Biotech S.L. Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
US9134297B2 (en) 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
EP2492688A1 (en) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molecular biomarkers for predicting response to antitumor treatment in lung cancer
WO2012129145A1 (en) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Nscle combination therapy
WO2012149014A1 (en) 2011-04-25 2012-11-01 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
JP6297490B2 (ja) 2011-08-31 2018-03-20 ジェネンテック, インコーポレイテッド 診断マーカー
SG11201400996SA (en) 2011-09-30 2014-04-28 Genentech Inc Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
WO2013190089A1 (en) 2012-06-21 2013-12-27 Pangaea Biotech, S.L. Molecular biomarkers for predicting outcome in lung cancer
JP6255038B2 (ja) 2013-02-26 2017-12-27 トリアクト セラピューティクス,インク. 癌治療
EP2976085A1 (en) 2013-03-21 2016-01-27 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
EP3044593A4 (en) 2013-09-09 2017-05-17 Triact Therapeutics, Inc. Cancer therapy
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
CA2969830A1 (en) 2014-12-24 2016-06-30 Genentech, Inc. Therapeutic, diagnostic and prognostic methods for cancer of the bladder
KR20230150408A (ko) 2016-12-22 2023-10-30 암젠 인크 폐암, 췌장암 또는 대장암을 치료하기 위한 kras g12c 억제제로서의 벤즈이소티아졸, 이소티아졸로[3,4-b]피리딘, 퀴나졸린, 프탈라진, 피리도[2,3-d]피리다진 및 피리도[2,3-d]피리미딘 유도체
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
SG11202001499WA (en) 2017-09-08 2020-03-30 Amgen Inc Inhibitors of kras g12c and methods of using the same
US11045484B2 (en) 2018-05-04 2021-06-29 Amgen Inc. KRAS G12C inhibitors and methods of using the same
EP3788038B1 (en) 2018-05-04 2023-10-11 Amgen Inc. Kras g12c inhibitors and methods of using the same
WO2019217691A1 (en) 2018-05-10 2019-11-14 Amgen Inc. Kras g12c inhibitors for the treatment of cancer
CA3098885A1 (en) 2018-06-01 2019-12-05 Amgen Inc. Kras g12c inhibitors and methods of using the same
EP4268898A3 (en) 2018-06-11 2024-01-17 Amgen Inc. Kras g12c inhibitors for treating cancer
US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
WO2020070239A1 (en) 2018-10-04 2020-04-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Egfr inhibitors for treating keratodermas
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3883565A1 (en) 2018-11-19 2021-09-29 Amgen Inc. Kras g12c inhibitors and methods of using the same
US20220002311A1 (en) 2018-12-20 2022-01-06 Amgen Inc. Kif18a inhibitors
EA202191730A1 (ru) 2018-12-20 2021-08-24 Эмджен Инк. Ингибиторы kif18a
AU2019403488A1 (en) 2018-12-20 2021-06-24 Amgen Inc. KIF18A inhibitors
US20220056015A1 (en) 2018-12-20 2022-02-24 Amgen Inc. Kif18a inhibitors
CA3130080A1 (en) 2019-03-01 2020-09-10 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
JP2022522778A (ja) 2019-03-01 2022-04-20 レボリューション メディシンズ インコーポレイテッド 二環式ヘテロシクリル化合物及びその使用
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
CR20210665A (es) 2019-05-21 2022-01-25 Amgen Inc Formas en estado sólido
MX2022001181A (es) 2019-08-02 2022-02-22 Amgen Inc Inhibidores de kif18a.
CN114302880A (zh) 2019-08-02 2022-04-08 美国安进公司 Kif18a抑制剂
JP2022542319A (ja) 2019-08-02 2022-09-30 アムジエン・インコーポレーテツド Kif18a阻害剤
US20220372018A1 (en) 2019-08-02 2022-11-24 Amgen Inc. Kif18a inhibitors
CA3155857A1 (en) 2019-10-24 2021-04-29 Amgen Inc. PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS KRAS G12C AND KRAS G12D INHIBITORS IN THE TREATMENT OF CANCER
TW202132314A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
JP2022553857A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ras阻害剤
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
AU2020380315A1 (en) 2019-11-08 2022-05-26 Revolution Medicines, Inc. Bicyclic heteroaryl compounds and uses thereof
JP2023501522A (ja) 2019-11-14 2023-01-18 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の改良合成法
AU2020381492A1 (en) 2019-11-14 2022-05-26 Amgen Inc. Improved synthesis of KRAS G12C inhibitor compound
CN114980976A (zh) 2019-11-27 2022-08-30 锐新医药公司 共价ras抑制剂及其用途
MX2022008305A (es) 2020-01-07 2022-08-08 Revolution Medicines Inc Dosificacion de inhibidores de shp2 y metodos de tratamiento del cancer.
WO2021156178A1 (en) 2020-02-03 2021-08-12 Boehringer Ingelheim International Gmbh [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors
US20230131720A1 (en) 2020-02-03 2023-04-27 Boehringer Ingelheim International Gmbh [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS
US11608343B2 (en) 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
MX2022016355A (es) 2020-06-18 2023-04-03 Revolution Medicines Inc Metodos para retardar, prevenir, y tratar la resistencia adquirida a inhibidores de ras.
EP4208261A1 (en) 2020-09-03 2023-07-12 Revolution Medicines, Inc. Use of sos1 inhibitors to treat malignancies with shp2 mutations
CN116457358A (zh) 2020-09-15 2023-07-18 锐新医药公司 作为ras抑制剂以治疗癌症的吲哚衍生物
CN117396472A (zh) 2020-12-22 2024-01-12 上海齐鲁锐格医药研发有限公司 Sos1抑制剂及其用途
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
EP4334324A1 (en) 2021-05-05 2024-03-13 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
AU2022270116A1 (en) 2021-05-05 2023-12-21 Revolution Medicines, Inc. Ras inhibitors
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023114954A1 (en) 2021-12-17 2023-06-22 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024081916A1 (en) 2022-10-14 2024-04-18 Black Diamond Therapeutics, Inc. Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
US20240279230A1 (en) 2022-12-22 2024-08-22 Boehringer Ingelheim International Gmbh Crystalline forms of a her2 inhibitor
WO2024206858A1 (en) 2023-03-30 2024-10-03 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024211663A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
WO2024211712A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
US20240352038A1 (en) 2023-04-14 2024-10-24 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
US20240352036A1 (en) 2023-04-14 2024-10-24 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CN1212694A (zh) 1999-03-31
EP0888351B1 (de) 2003-10-15
DE19608588A1 (de) 1997-09-11
BG102789A (en) 1999-09-30
IL125342A0 (en) 1999-03-12
UA54421C2 (uk) 2003-03-17
CA2248720A1 (en) 1997-09-12
US5821240A (en) 1998-10-13
NO984082L (no) 1998-09-04
HUP9902049A3 (en) 2000-03-28
RU2195461C2 (ru) 2002-12-27
AU730376B2 (en) 2001-03-08
KR19990087504A (ko) 1999-12-27
NO984082D0 (no) 1998-09-04
CZ281598A3 (cs) 1999-02-17
AU2094597A (en) 1997-09-22
PL328719A1 (en) 1999-02-15
AR006108A1 (es) 1999-08-11
MX9807073A (es) 1998-12-31
EP0888351A1 (de) 1999-01-07
ATE252101T1 (de) 2003-11-15
BG63163B1 (bg) 2001-05-31
HUP9902049A2 (hu) 1999-10-28
TW454008B (en) 2001-09-11
NZ331545A (en) 2000-03-27
EE9800278A (et) 1999-02-15
SK120898A3 (en) 1999-02-11
DE59710864D1 (de) 2003-11-20
UY24474A1 (es) 2000-09-29
CO4650043A1 (es) 1998-09-03
JP2000506151A (ja) 2000-05-23
TR199801755T2 (xx) 1998-12-21
ZA971887B (en) 1998-09-07
WO1997032880A1 (de) 1997-09-12
NO311522B1 (no) 2001-12-03
HK1018450A1 (en) 1999-12-24
CN1064362C (zh) 2001-04-11

Similar Documents

Publication Publication Date Title
BR9707839A (pt) Primido-Ú5,4-D¾-primidas medicamentos contendo esses compostos sua aplicação e processo para a sua preparação
PT1086092E (pt) Derivados de 1,1-dioxido-benzo (b) tiepina processo para a sua producao medicamentos contendo esses compostos e a sua utilizacao
BR9510360A (pt) Derivados de piperazina medicamentos contendo esses compostos sua aplicação e processo para sua preparação
PT909327E (pt) Eritromicinas e processo para a sua preparacao
PT799866E (pt) Negro-de-fumo e processo para a sua preparacao
BR9503638A (pt) Composto processo para sua produção e formulação farmacêutica
BR9505940A (pt) Comprimido mastigável e processo para sua preparação
BR9505527A (pt) Catalisador para a desidratação de c6-a c15-parafinas e processo para sua preparação
BR9807845B1 (pt) pó de tántalo e processo para a sua produção.
BR9505051A (pt) Composto derivado de 2,4-oxazolidinodiona processo para a sua produção e composição farmacêutica
BR9600992A (pt) Compostos piridonassulfonil uréia processo para sua produção e herbicidas contendo os mesmos
BR9601093A (pt) Pirido(3,2-E)pirazinoas processo para sua preparação medicamentos processo para sua preparação e utilização
BR9501980A (pt) Copolimeros,processo para sua preparação
BR9202325A (pt) Composto,processo para a sua preparacao,preparado farmaceutico e processo para a sua preparacao
BR9101121A (pt) Composto,processo para sua preparacao,suas aplicacoes,e preparado farmaceutico
BR9303456A (pt) Compostos,processo para sua preparacao,medicamentos,processo para sua preparacao e emprego
BR9104948A (pt) Compostos,processo para a sua producao,agente farmaceutico e processo para a sua producao
BR9711340A (pt) Composto composi-Æo farmac-utica e processo para preparar um composto
BR9305161A (pt) Composto, composição farmacêutica e processo para a preparação do composto
BR9602337A (pt) Composto processo para sua preparação usos do mesmo processo para tratamento de arritmias e medicamento
PT1015433E (pt) 1,2,3,4,5,6-hexa-hidro-2,6-metano-3-benzazocin-10-ois substituidos processo para a sua producao e sua utilizacao como medicamentos
BR1100524A (pt) Compostos, processo para sua preparação; compostos intermediários para os mesmos, e composições farmacêuticas
BR9600732A (pt) Processo para proporcionar a estabilidade de pó de polímero aperfeiçoada
BR9401483A (pt) Composto e processo para sua preparação
PT1086077E (pt) Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements