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PT1086077E - Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica - Google Patents

Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica

Info

Publication number
PT1086077E
PT1086077E PT99931059T PT99931059T PT1086077E PT 1086077 E PT1086077 E PT 1086077E PT 99931059 T PT99931059 T PT 99931059T PT 99931059 T PT99931059 T PT 99931059T PT 1086077 E PT1086077 E PT 1086077E
Authority
PT
Portugal
Prior art keywords
preparing
pharmaceutical composition
novel process
novel
pharmaceutical
Prior art date
Application number
PT99931059T
Other languages
English (en)
Inventor
Ulrich Klar
Karsten Parczyk
Rosemarie Lichtner
Rolf Bohlmann
Monika Lessl
Karl-Heinrich Fritzemeier
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT1086077E publication Critical patent/PT1086077E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
PT99931059T 1998-06-09 1999-06-09 Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica PT1086077E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19826213A DE19826213A1 (de) 1998-06-09 1998-06-09 Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Publications (1)

Publication Number Publication Date
PT1086077E true PT1086077E (pt) 2004-08-31

Family

ID=7870694

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99931059T PT1086077E (pt) 1998-06-09 1999-06-09 Novos antiestrogeneos processo para a sua preparacao e sua utilizacao farmaceutica

Country Status (21)

Country Link
US (3) US6166075A (pt)
EP (1) EP1086077B1 (pt)
JP (1) JP2002517482A (pt)
KR (1) KR20010052688A (pt)
CN (1) CN1305457A (pt)
AR (1) AR023629A1 (pt)
AT (1) ATE263755T1 (pt)
AU (1) AU759942B2 (pt)
BR (1) BR9911103A (pt)
CA (1) CA2334780A1 (pt)
CO (1) CO5050355A1 (pt)
DE (2) DE19826213A1 (pt)
DK (1) DK1086077T3 (pt)
ES (1) ES2220072T3 (pt)
HU (1) HUP0102211A3 (pt)
IL (1) IL139863A0 (pt)
PE (1) PE20000541A1 (pt)
PL (1) PL344309A1 (pt)
PT (1) PT1086077E (pt)
WO (1) WO1999064393A1 (pt)
ZA (1) ZA200100201B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
DE10039199A1 (de) * 2000-08-10 2002-02-21 Schering Ag Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
US20040110769A1 (en) * 2001-02-15 2004-06-10 End David William Farnesyl protein transferase inhibitor combinations with antiestrogen agents
DE10142881A1 (de) * 2001-09-03 2003-04-03 Jomed Gmbh Implantate mit Combretastatin A-4 (CA4)
AU2004251176A1 (en) * 2003-05-31 2005-01-06 Janssen Pharmaceutica, N.V. Cyclohexyl derivatives as selective estrogen receptor modulators
US7750631B2 (en) * 2007-06-22 2010-07-06 Morpho Detection, Inc. Passenger inspection system and methods for using the same
US20090234024A1 (en) 2008-02-04 2009-09-17 Hooman Shadnia Estrogenic compounds, process for their production and pharmaceutical uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
FR2685332A1 (fr) * 1991-12-20 1993-06-25 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments.
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
FR2744445B1 (fr) * 1996-02-01 1998-10-02 Roussel Uclaf Composes biphenyles nouveaux et/ou a titre de medicament, compositions pharmaceutiques les contenant, leur procede de preparation et les intermediaires de ce procede
DE19826213A1 (de) * 1998-06-09 1999-12-16 Schering Ag Neue Antiestrogene, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Also Published As

Publication number Publication date
JP2002517482A (ja) 2002-06-18
US20030162830A1 (en) 2003-08-28
AU4771699A (en) 1999-12-30
US6166075A (en) 2000-12-26
EP1086077B1 (de) 2004-04-07
DE19826213A1 (de) 1999-12-16
KR20010052688A (ko) 2001-06-25
PE20000541A1 (es) 2000-08-10
CN1305457A (zh) 2001-07-25
DK1086077T3 (da) 2004-08-02
AU759942B2 (en) 2003-05-01
EP1086077A1 (de) 2001-03-28
IL139863A0 (en) 2002-02-10
ES2220072T3 (es) 2004-12-01
PL344309A1 (en) 2001-10-22
ATE263755T1 (de) 2004-04-15
AR023629A1 (es) 2002-09-04
DE59909123D1 (de) 2004-05-13
CO5050355A1 (es) 2001-06-27
WO1999064393A1 (de) 1999-12-16
US6559181B1 (en) 2003-05-06
US7074829B2 (en) 2006-07-11
HUP0102211A2 (hu) 2002-03-28
ZA200100201B (en) 2002-01-08
HUP0102211A3 (en) 2002-12-28
CA2334780A1 (en) 1999-12-16
BR9911103A (pt) 2001-03-06

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