BR9306748A - Esterõides 17-alquilacetona úteis como inbidores 5- -redutase - Google Patents

Esterõides 17-alquilacetona úteis como inbidores 5- -redutase

Info

Publication number: BR9306748A
Authority: BR; Brazil
Prior art keywords: alkylacetone; reductase inhibitors; steroids useful; steroids; useful
Prior art date: 1992-06-30

Application number

BR9306748A

Other languages

English (en)

Portuguese (pt)

Inventor

Dennis Alan Holt

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1993-06-30

Publication date

1998-12-08

1993-06-30 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1998-12-08 Publication of BR9306748A publication Critical patent/BR9306748A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BR9306748A 1992-06-30 1993-06-30 Esterõides 17-alquilacetona úteis como inbidores 5- -redutase BR9306748A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929213835A GB9213835D0 (en)	1992-06-30	1992-06-30	Compounds
PCT/US1993/006238 WO1994000125A1 (fr)	1992-06-30	1993-06-30	STEROIDES 17-AKYLCETONIQUES UTILES COMME INHIBITEURS DE 5-α-REDUCTASE

Publications (1)

Publication Number	Publication Date
BR9306748A true BR9306748A (pt)	1998-12-08

Family

ID=10717920

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9306748A BR9306748A (pt)	1992-06-30	1993-06-30	Esterõides 17-alquilacetona úteis como inbidores 5- -redutase

Country Status (23)

Country	Link
EP (1)	EP0651643A4 (fr)
JP (1)	JPH08500821A (fr)
KR (1)	KR950702118A (fr)
CN (1)	CN1095382A (fr)
AP (1)	AP412A (fr)
AU (1)	AU4545993A (fr)
BG (1)	BG99313A (fr)
BR (1)	BR9306748A (fr)
CA (1)	CA2138956A1 (fr)
CZ (1)	CZ334694A3 (fr)
FI (1)	FI946189A0 (fr)
GB (1)	GB9213835D0 (fr)
HU (1)	HUT69409A (fr)
IL (1)	IL106158A0 (fr)
MA (1)	MA22927A1 (fr)
MX (1)	MX9303970A (fr)
NO (1)	NO945074L (fr)
OA (1)	OA10122A (fr)
RU (1)	RU94046378A (fr)
SI (1)	SI9300350A (fr)
SK (1)	SK159994A3 (fr)
WO (1)	WO1994000125A1 (fr)
ZA (1)	ZA934645B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925774A (en)	1991-01-07	1999-07-20	Pherin Corporation	Estrenes for inducing hypothalamic effects
AU676478B2 (en) *	1992-05-20	1997-03-13	Merck & Co., Inc.	New delta-17 and delta-20 olefinic and saturated 17beta- substituted-4-aza-5alpha-androstan-3-ones as 5alpha- reductase inhibitors
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic
JP2015129095A (ja)	2013-12-19	2015-07-16	ロレアル	組成物
EP3750908A4 (fr) *	2018-02-11	2022-07-27	Jiangsu Hansoh Pharmaceutical Group Co., Ltd.	Régulateur de dérivé de stéroïde, son procédé de préparation et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954446A (en) *	1988-05-25	1990-09-04	Smithkline Beecham Corporation	Aromatic steroid 5-α-reductase inhibitors

1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/xx unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/fr unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/xx unknown
- 1993-06-30 SI SI9300350A patent/SI9300350A/sl unknown
- 1993-06-30 CN CN93109540A patent/CN1095382A/zh active Pending
- 1993-06-30 SK SK1599-94A patent/SK159994A3/sk unknown
- 1993-06-30 MX MX9303970A patent/MX9303970A/es unknown
- 1993-06-30 EP EP93915499A patent/EP0651643A4/fr not_active Withdrawn
- 1993-06-30 CA CA002138956A patent/CA2138956A1/fr not_active Abandoned
- 1993-06-30 BR BR9306748A patent/BR9306748A/pt not_active Application Discontinuation
- 1993-06-30 JP JP6502660A patent/JPH08500821A/ja active Pending
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/cs unknown
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
- 1993-06-30 HU HU9403833A patent/HUT69409A/hu unknown
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/ru unknown
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/fr not_active Application Discontinuation
- 1993-06-30 FI FI946189A patent/FI946189A0/fi not_active Application Discontinuation
1994
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/ko not_active Withdrawn
- 1994-12-29 NO NO945074A patent/NO945074L/no unknown
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-29 BG BG99313A patent/BG99313A/xx unknown

Also Published As

Publication number	Publication date
RU94046378A (ru)	1996-10-10
CZ334694A3 (en)	1995-10-18
MA22927A1 (fr)	1994-04-01
OA10122A (en)	1996-12-18
AP9300542A0 (en)	1993-07-31
AU4545993A (en)	1994-01-24
SI9300350A (sl)	1993-12-31
FI946189A7 (fi)	1994-12-30
SK159994A3 (en)	1996-01-10
FI946189L (fi)	1994-12-30
HUT69409A (en)	1995-09-28
BG99313A (en)	1995-09-29
GB9213835D0 (en)	1992-08-12
CA2138956A1 (fr)	1994-01-06
EP0651643A4 (fr)	1995-10-04
FI946189A0 (fi)	1994-12-30
AP412A (en)	1995-09-29
IL106158A0 (en)	1993-10-20
ZA934645B (en)	1994-01-25
EP0651643A1 (fr)	1995-05-10
WO1994000125A1 (fr)	1994-01-06
CN1095382A (zh)	1994-11-23
NO945074L (no)	1995-02-16
NO945074D0 (no)	1994-12-29
MX9303970A (es)	1994-04-29
KR950702118A (ko)	1995-06-19
JPH08500821A (ja)	1996-01-30

Publication	Publication Date	Title
FI904101A7 (fi)	1991-02-22	17B-asyyli-4-atsa-5a-androst-1-en-3-en-3-oneja 5a-reduktaasi-inhibiittoreina
FI940903A7 (fi)	1994-04-20	Steroidisulfataasi-inhibiittorit
BR9206577A (pt)	1995-10-10	Heteroalilaminas que atuam como novos inibidores de acetilcolinesterase
FI945457A7 (fi)	1995-01-16	Testosteronin 5alfa-reduktaasiaktiviteetin inhibiittorit
FI933363L (fi)	1994-01-30	17-spirometylensteroider
FI933510A7 (fi)	1994-02-12	Graensytaktiva foereningar baserade pao modifierade risinoljefettderivat
NO941642D0 (no)	1994-05-04	Brokran
FI931373L (fi)	1993-09-28	Steroidderivat
FI945416L (fi)	1994-11-17	Dolastatiinijohdannaisia
FI931740L (fi)	1993-10-18	Semisyntetiska glukosaminoglykaner innehaollande a-l-galakturonsyra somaer substituerad i 3-staellning med nukleofila radikaler
FI944349A7 (fi)	1994-09-20	Jännitekisko
FI953130L (fi)	1995-06-22	Uudet steroidit
DE59304856D1 (de)	1997-02-06	Sterilisiertunnel
BR9306748A (pt)	1998-12-08	Esterõides 17-alquilacetona úteis como inbidores 5- -redutase
FI933487L (fi)	1994-02-08	Jaestvaerdstammor med defekter i N-glykosyleringen
FI933395L (fi)	1994-01-31	Pao undecylensyraester baserat desodoriseringsmedel foer papperindustrins avlopp
FI946081A7 (fi)	1994-12-23	Steroidaalinen beta-0-sellobiosidihepta-alkanoaattimenetelmä
FI953106A7 (fi)	1995-07-13	Difuoripentapeptidijohdannaiset anti-inflammatorisina aineina
FI933763L (fi)	1994-03-01	Graensytaktiva foereningar baserade pao alkoxylerade fettaminer
FI931411A0 (fi)	1993-03-29	Testningsapparat foer bromssystem
FI930932A7 (fi)	1993-09-08	Pao aendytasidiga stoedarmar stoett svaengtak foer jaernvaegsgodsvagnar
BR9508344A (pt)	1998-07-14	Triterpenos tetracíclicos
FI931477A0 (fi)	1993-04-01	Foerfarande foer dataoeverfoering pao telefonlinjer
FI37U1 (fi)	1992-02-28	Tillaegsanordning i samband med personlyftaren
MX9203683A (es)	1992-08-01	4-amino-4-ene-esteroides y su uso como inhibidores de 5-alfa-reductasa.

Legal Events

Date	Code	Title	Description
1999-10-13	FA7	Application withdrawn (art. 18 par. 1 of law 5772/71) - being contrary to morals, good customs and public security, order and health