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BR0308250A - Métodos de indução de diferenciação terminal - Google Patents

Métodos de indução de diferenciação terminal

Info

Publication number
BR0308250A
BR0308250A BR0308250A BR0308250A BR0308250A BR 0308250 A BR0308250 A BR 0308250A BR 0308250 A BR0308250 A BR 0308250A BR 0308250 A BR0308250 A BR 0308250A BR 0308250 A BR0308250 A BR 0308250A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
terminal differentiation
present
therapeutically effective
active compounds
Prior art date
Application number
BR0308250A
Other languages
English (en)
Inventor
Victoria M Richon
Original Assignee
Aton Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27805074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0308250(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aton Pharma Inc filed Critical Aton Pharma Inc
Publication of BR0308250A publication Critical patent/BR0308250A/pt

Links

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Abstract

"MéTODOS DE INDUçãO DE DIFERENCIAçãO TERMINAL". A presente invenção fornece métodos de induzir seletivamente a diferenciação terminal, a interrupção do crescimento da célula e/ou a apoptose de células neoplásicas e/ou a inibição de histona desacetilase (HDAC) por administração de composições farmacêuticas que compreendem potentes inibidores de HDAC. A biodisponibilidade oral dos compostos ativos nas composições farmacêuticas da presente invenção é surpreendentemente alta. Além disso, as composições farmacêuticas inesperadamente dão origem a altos níveis no sangue dos compostos ativos terapeuticamente eficazes durante um extenso período de tempo. A presente invenção fornece ainda um regime seguro de dosagem diária destas composições farmacêuticas, que é fácil de se seguir e que resulta em uma quantidade terapeuticamente eficaz dos inibidores de HDAC in vivo.
BR0308250A 2002-03-04 2003-03-04 Métodos de indução de diferenciação terminal BR0308250A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36175902P 2002-03-04 2002-03-04
PCT/US2003/006451 WO2003075839A2 (en) 2002-03-04 2003-03-04 Methods of inducing terminal differentiation

Publications (1)

Publication Number Publication Date
BR0308250A true BR0308250A (pt) 2005-01-11

Family

ID=27805074

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308250A BR0308250A (pt) 2002-03-04 2003-03-04 Métodos de indução de diferenciação terminal

Country Status (17)

Country Link
US (7) US20040072735A1 (pt)
EP (4) EP2266552A3 (pt)
JP (4) JP4732693B2 (pt)
KR (2) KR100868813B1 (pt)
CN (3) CN101259120B (pt)
AU (1) AU2003213684C1 (pt)
BR (1) BR0308250A (pt)
CA (3) CA2478094C (pt)
ES (1) ES2532607T3 (pt)
IL (3) IL163909A0 (pt)
MX (1) MXPA04008577A (pt)
NO (2) NO329984B1 (pt)
NZ (3) NZ550185A (pt)
PL (1) PL372239A1 (pt)
RU (3) RU2394022C2 (pt)
WO (1) WO2003075839A2 (pt)
ZA (2) ZA200407942B (pt)

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US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US20040087657A1 (en) * 2001-10-16 2004-05-06 Richon Victoria M. Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors
JP2005525345A (ja) * 2002-02-15 2005-08-25 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｔｒｘ媒介性疾患を処置する方法
NZ550185A (en) * 2002-03-04 2008-10-31 Merck Hdac Res Llc Methods of inducing terminal differentiation Methods of inducing terminal differentiation
US20060276547A1 (en) * 2002-03-04 2006-12-07 Bacopoulos Nicholas G Methods of treating cancer with HDAC inhibitors
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
US7456219B2 (en) * 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
US20070060614A1 (en) * 2002-03-04 2007-03-15 Bacopoulos Nicholas G Methods of treating cancer with hdac inhibitors
US7148257B2 (en) 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
IL164599A0 (en) * 2002-04-15 2005-12-18 Sloan Kettering Inst Cancer Combination therapy for the treatment of cancer
TW559390U (en) * 2002-08-27 2003-10-21 Molex Inc Electrical connector
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
FR2847817B1 (fr) * 2002-11-28 2006-11-10 Centre Nat Rech Scient Utilisation d'un inhibiteur d'histone deacetylase pour le traitement des dystrophies musculaires
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CA2671976C (en) 2016-05-10
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IL197582A (en) 2014-05-28
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