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AR035659A1 - Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos - Google Patents

Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos

Info

Publication number
AR035659A1
AR035659A1 ARP010105504A ARP010105504A AR035659A1 AR 035659 A1 AR035659 A1 AR 035659A1 AR P010105504 A ARP010105504 A AR P010105504A AR P010105504 A ARP010105504 A AR P010105504A AR 035659 A1 AR035659 A1 AR 035659A1
Authority
AR
Argentina
Prior art keywords
compounds
alkyl
group
oxo
manufacture
Prior art date
Application number
ARP010105504A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR035659A1 publication Critical patent/AR035659A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Hidroxiamidas de ácido (1-oxo-1,2,3,4-tetrahidro-naftalén-2-il)-alcanoico de fórmula (1), en donde: R1 es seleccionado de entre el grupo consistente en hidrógeno, alquilo C1-4, COOH, ó COO-alquilo C1-4; R2, R3, R4 y R5 independientemente entre sí, son seleccionados de entre el grupo consistente en hidrógeno, un átomo de halógeno, un grupo alquilo C1-4, trifluormetilo, hidroxi, alcoxi C1-4, ariloxi, arilalquiloxi, nitro, amino, alquil C1-4-amino, di(alquil C1-4)-amino, piperidino, morfolino, pirrolidino, alcanoílamino C1-4, o un grupo arilo, o un grupo heteroarilo, o, R2 y R3 conjuntamente o R3 y R4 conjuntamente o R4 y R5 conjuntamente, respectivamente, pueden formar un anillo alquilendioxi C1-3, o R2 y R3 conjuntamente o R3 y R4 conjuntamente o R4 y R5 conjuntamente, respectivamente, pueden formar una cadena alquileno C3-5; Y es -CH2-CH2-; X es una cadena alquileno C4-10 que puede estar saturada o no saturada con uno o dos enlaces dobles o uno o dos enlaces triples o un enlace doble y un enlace triple, y que puede estar ramificada o sin ramificar o interrumpida por un anillo cicloalquilo C3-7; sus enantiómeros, diastereoisómeros y racematos, así como también sus sales con ácidos y bases farmacéuticamente aceptables. Dichos compuestos presentan actividad inhibidora de la histona deacetilasa (HDAC), y son útiles en el tratamiento del cáncer. También se dan a conocer un proceso para la manufactura de estos compuestos, composiciones farmacéuticas que contienen dichos compuestos y los usos de los mismos.
ARP010105504A 2000-12-07 2001-11-27 Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos AR035659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00126820 2000-12-07

Publications (1)

Publication Number Publication Date
AR035659A1 true AR035659A1 (es) 2004-06-23

Family

ID=8170594

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105504A AR035659A1 (es) 2000-12-07 2001-11-27 Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos

Country Status (26)

Country Link
US (1) US6531472B2 (es)
EP (1) EP1349830A1 (es)
JP (1) JP4091431B2 (es)
KR (1) KR20030077551A (es)
CN (1) CN100340545C (es)
AR (1) AR035659A1 (es)
AU (2) AU2002216074C1 (es)
BG (1) BG107889A (es)
BR (1) BR0115988A (es)
CA (1) CA2430355A1 (es)
CZ (1) CZ20031833A3 (es)
EC (1) ECSP034642A (es)
HK (1) HK1060875A1 (es)
HR (1) HRP20030451A2 (es)
HU (1) HUP0400579A2 (es)
IL (1) IL156133A0 (es)
MA (1) MA26972A1 (es)
MX (1) MXPA03004947A (es)
NO (1) NO20032531L (es)
NZ (1) NZ526051A (es)
PL (1) PL365324A1 (es)
RU (1) RU2288220C2 (es)
SK (1) SK8512003A3 (es)
WO (1) WO2002046144A1 (es)
YU (1) YU45803A (es)
ZA (1) ZA200304262B (es)

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JP2006520796A (ja) * 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
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Also Published As

Publication number Publication date
CN100340545C (zh) 2007-10-03
NO20032531D0 (no) 2003-06-04
EP1349830A1 (en) 2003-10-08
NO20032531L (no) 2003-06-04
BG107889A (bg) 2004-06-30
CN1478072A (zh) 2004-02-25
AU2002216074B2 (en) 2006-01-05
ECSP034642A (es) 2003-07-25
HRP20030451A2 (en) 2005-04-30
PL365324A1 (en) 2004-12-27
KR20030077551A (ko) 2003-10-01
HUP0400579A2 (hu) 2004-06-28
HK1060875A1 (en) 2004-08-27
JP4091431B2 (ja) 2008-05-28
MXPA03004947A (es) 2003-09-10
AU1607402A (en) 2002-06-18
RU2288220C2 (ru) 2006-11-27
AU2002216074C1 (en) 2006-12-07
WO2002046144A1 (en) 2002-06-13
SK8512003A3 (en) 2004-04-06
ZA200304262B (en) 2004-08-30
NZ526051A (en) 2004-12-24
IL156133A0 (en) 2003-12-23
YU45803A (sh) 2006-05-25
US20020065282A1 (en) 2002-05-30
CA2430355A1 (en) 2002-06-13
MA26972A1 (fr) 2004-12-20
JP2004515488A (ja) 2004-05-27
US6531472B2 (en) 2003-03-11
BR0115988A (pt) 2004-01-13
CZ20031833A3 (cs) 2004-02-18

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