BR0308146A - Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto - Google Patents
Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um compostoInfo
- Publication number
- BR0308146A BR0308146A BR0308146-0A BR0308146A BR0308146A BR 0308146 A BR0308146 A BR 0308146A BR 0308146 A BR0308146 A BR 0308146A BR 0308146 A BR0308146 A BR 0308146A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- hydroxy
- hydrogen
- halo
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". Amidas heterocíclicas de fórmula (1) em que: X é N ou CH; R^ 4^ e R^ 5^ em conjunto são -S-C(R^ 6^)=C(R^ 7^)- ou -C(R^ 7^)=C(R^ 6^)-S-; R^ 6^ e R^ 7^ são selecionados independentemente de, por exemplo hidrogênio, halo e alquila C~ 1-4~, A é fenileno ou heteroarileno; n é 0, 1 ou 2; R^ 1^ é selecionado, por exemplo, de halo, nitro, ciano, hidróxi, carbóxi; R^ 2^ é hidrogênio, hidróxi ou carbóxi; R^ 3^ é selecionado, por exemplo, de hidrogênio, hidróxi, arila, heterociclila e alquila C~ 1-4~ (opcionalmente substituido por 1 ou 2 grupos R^ 8^); R^ 8^ é selecionado, por exemplo, de hidróxi, -COCOOR^ 9^, -C(O)N(R^ 9^)(R^ 10^), -NHC(O)R^ 9^, (R^ 9^)(R^ 10^)N -COOR^ 9^; R^ 9^ e R^ 10^ são selecionados, por exemplo, de hidrogênio, hidróxi, alquila C~ 1-4~ (opcionalmente substituído por 1 ou 2 R^ 13^); R^ 13^ é selecionado de hidróxi, halo, trialometila e alcóxi C~ 1-4~; ou um seu sal ou pró-droga farmaceuticamente aceitável; apresentam atividade inibidora de glicogênio fosforilase e, assim, possuem são valiosas no tratamento de estados de doença associados com atividade incrementada de glicogênio fosforilase. Descreve-se processos para a manufatura de referidos derivados de amida heterocílica e composições farmacêuticas contendo os mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0205165.4A GB0205165D0 (en) | 2002-03-06 | 2002-03-06 | Chemical compounds |
PCT/GB2003/000877 WO2003074532A1 (en) | 2002-03-06 | 2003-03-04 | Heterocyclic amide derivatives as inhibitors of glycogen phosphorylase |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308146A true BR0308146A (pt) | 2004-12-07 |
Family
ID=9932329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308146-0A BR0308146A (pt) | 2002-03-06 | 2003-03-04 | Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto |
Country Status (18)
Country | Link |
---|---|
US (2) | US7129249B2 (pt) |
EP (1) | EP1483270A1 (pt) |
JP (1) | JP2005526058A (pt) |
KR (1) | KR20040096661A (pt) |
CN (1) | CN100384852C (pt) |
AR (1) | AR038888A1 (pt) |
AU (1) | AU2003214377A1 (pt) |
BR (1) | BR0308146A (pt) |
CA (1) | CA2477667A1 (pt) |
GB (1) | GB0205165D0 (pt) |
IL (1) | IL163803A0 (pt) |
MX (1) | MXPA04008614A (pt) |
NO (1) | NO20043852L (pt) |
NZ (1) | NZ534990A (pt) |
PL (1) | PL372973A1 (pt) |
TW (1) | TW200305412A (pt) |
WO (1) | WO2003074532A1 (pt) |
ZA (1) | ZA200406679B (pt) |
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GB0205162D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205176D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
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GB0222909D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0222912D0 (en) | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
GB0320422D0 (en) * | 2003-08-30 | 2003-10-01 | Astrazeneca Ab | Chemical compounds |
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SG10201406631TA (en) * | 2009-10-16 | 2014-11-27 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
EA201270568A1 (ru) | 2009-10-16 | 2012-11-30 | Риб-Экс Фармасьютикалз, Инк. | Антимикробные композиции и способы их получения и применения |
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CN109553580B (zh) * | 2017-09-25 | 2023-08-11 | 南京长澳医药科技有限公司 | 硝基咪唑类化合物中间体及其盐的制备方法 |
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GB0319759D0 (en) | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
WO2005020986A1 (en) | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity |
WO2005020985A1 (en) | 2003-08-29 | 2005-03-10 | Astrazeneca Ab | Indolamide derivatives which possess glycogen phosphorylase inhibitory activity |
GB0320422D0 (en) | 2003-08-30 | 2003-10-01 | Astrazeneca Ab | Chemical compounds |
-
2002
- 2002-03-06 GB GBGB0205165.4A patent/GB0205165D0/en not_active Ceased
-
2003
- 2003-03-04 EP EP03709947A patent/EP1483270A1/en not_active Withdrawn
- 2003-03-04 WO PCT/GB2003/000877 patent/WO2003074532A1/en active Application Filing
- 2003-03-04 JP JP2003573000A patent/JP2005526058A/ja not_active Withdrawn
- 2003-03-04 US US10/506,741 patent/US7129249B2/en not_active Expired - Fee Related
- 2003-03-04 PL PL03372973A patent/PL372973A1/xx not_active Application Discontinuation
- 2003-03-04 BR BR0308146-0A patent/BR0308146A/pt not_active IP Right Cessation
- 2003-03-04 AU AU2003214377A patent/AU2003214377A1/en not_active Abandoned
- 2003-03-04 CN CNB038102145A patent/CN100384852C/zh not_active Expired - Fee Related
- 2003-03-04 KR KR10-2004-7013863A patent/KR20040096661A/ko not_active Application Discontinuation
- 2003-03-04 NZ NZ534990A patent/NZ534990A/en unknown
- 2003-03-04 IL IL16380303A patent/IL163803A0/xx unknown
- 2003-03-04 MX MXPA04008614A patent/MXPA04008614A/es active IP Right Grant
- 2003-03-04 CA CA002477667A patent/CA2477667A1/en not_active Abandoned
- 2003-03-05 TW TW092104650A patent/TW200305412A/zh unknown
- 2003-03-06 AR ARP030100768A patent/AR038888A1/es unknown
-
2004
- 2004-08-23 ZA ZA200406679A patent/ZA200406679B/en unknown
- 2004-09-14 NO NO20043852A patent/NO20043852L/no not_active Application Discontinuation
-
2006
- 2006-08-08 US US11/463,144 patent/US7276517B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2477667A1 (en) | 2003-09-12 |
WO2003074532A1 (en) | 2003-09-12 |
JP2005526058A (ja) | 2005-09-02 |
IL163803A0 (en) | 2005-12-18 |
NZ534990A (en) | 2006-02-24 |
KR20040096661A (ko) | 2004-11-16 |
NO20043852L (no) | 2004-09-14 |
ZA200406679B (en) | 2005-01-18 |
US7129249B2 (en) | 2006-10-31 |
AR038888A1 (es) | 2005-02-02 |
CN1653070A (zh) | 2005-08-10 |
MXPA04008614A (es) | 2004-12-06 |
AU2003214377A1 (en) | 2003-09-16 |
US7276517B2 (en) | 2007-10-02 |
EP1483270A1 (en) | 2004-12-08 |
CN100384852C (zh) | 2008-04-30 |
TW200305412A (en) | 2003-11-01 |
GB0205165D0 (en) | 2002-04-17 |
US20050131015A1 (en) | 2005-06-16 |
PL372973A1 (en) | 2005-08-08 |
US20070043069A1 (en) | 2007-02-22 |
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