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ES2081747B1 - Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. - Google Patents

Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Info

Publication number
ES2081747B1
ES2081747B1 ES9301917A ES9301917A ES2081747B1 ES 2081747 B1 ES2081747 B1 ES 2081747B1 ES 9301917 A ES9301917 A ES 9301917A ES 9301917 A ES9301917 A ES 9301917A ES 2081747 B1 ES2081747 B1 ES 2081747B1
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
preparation
tienopirroles
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9301917A
Other languages
English (en)
Other versions
ES2081747A1 (es
Inventor
Jover Antonio Torrens
Prio Jose Mas
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to ES9301917A priority Critical patent/ES2081747B1/es
Publication of ES2081747A1 publication Critical patent/ES2081747A1/es
Application granted granted Critical
Publication of ES2081747B1 publication Critical patent/ES2081747B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

AMIDAS DERIVADAS DE TIENOPIRROLES, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. COMPUESTOS DE FORMULA GENERAL (I), DONDE: X1 Y X2, DIFERENTES, CORRESPONDEN A CARBONO O AZUFRE, INDISTINTAMENTE R1 REPRESENTA COMPUESTOS DE FORMULA (IA) O (IB); R2 ES HIDROGENO O ALQUILO DE C1-C6; R3 Y R4 SON HIDROGENO, ALQUILO, HALOGENO, HIUROXILO, ALCOXILO, CIANO O NITRO, INDISTINTAMENTE; R5 ES HIDROGENO, ALQUILO DE C1-C6, ARILO, ARALQUILO, ALCOXICARBONILO, FENILALQUILOXICARBONILO, ALQUILSULFONILO, TENILSULFONILO, ALQUILOXIALQUILO O HIDROXICARBONILALQUILO; R6 ES HIDROGENO, ALQUILO DE C1-C6, HIDROXICARBONILALQUILO, ALCOXICARBONILO O ALCOXICARBONILALQUILO; R7 ES HIDROGENO, ALCOXILO O HALOGENO; R8 ES 3-INDOLILMETILO, HIDROXICARBONILALQUILO O BENCILOXICARBONILALQUILO; R9 ES HIDROXILO O NITROGENO UNIDO A R10 Y R11; R10 Y R11 SON, INDEPENDIENTEMENTE, HIDROGENO ALQUILO DE C1-C6, PREFERENTEMENTE N-PENTILO O HIDROXICARBONILALQUILO; -Z7 Z2 REPRESENTA C=N- O N-C=O. SU PROCEDIMIENTO DE PREPARACION, CONSISTENTE EN REACCIONAR DERIVADOS CARBOXILICOS CON AMINAS RACEMICAS EN DISOLVENTES ORGANICOS ANHIDRO O HIDRATADOS, SUS SALES FISIOLOGICAMENTE ACEPTABLES, COMO MEDICAMENTOS DESTINADOS AL TRATAMIENTO, ENTRE OTROS, DE LAS DISFUNCIONES INTESTINALES.
ES9301917A 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. Expired - Lifetime ES2081747B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301917A ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301917A ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Publications (2)

Publication Number Publication Date
ES2081747A1 ES2081747A1 (es) 1996-03-01
ES2081747B1 true ES2081747B1 (es) 1997-01-16

Family

ID=8283002

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301917A Expired - Lifetime ES2081747B1 (es) 1993-09-07 1993-09-07 Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.

Country Status (1)

Country Link
ES (1) ES2081747B1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329950B2 (en) 2005-07-06 2012-12-11 Sunovion Pharmaceuticals Inc. Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine
US8524950B2 (en) 2006-03-31 2013-09-03 Sunovion Pharmaceuticals Inc. Preparation of chiral amides and amines

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
EP1088824B1 (en) * 1999-09-30 2004-01-07 Pfizer Products Inc. Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
JP2007517056A (ja) 2003-12-29 2007-06-28 セプラコア インコーポレーテッド ピロール及びピラゾールｄａａｏ阻害剤
RU2430913C2 (ru) 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
AU2006335174B2 (en) 2006-01-06 2012-09-06 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
KR101581289B1 (ko) 2007-05-31 2015-12-31 세프라코 아이엔시. 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민
EP3414239A2 (en) 2016-02-05 2018-12-19 Denali Therapeutics Inc. Inhibitors of receptor-interacting protein kinase 1
PL3552017T3 (pl) 2016-12-09 2022-08-08 Denali Therapeutics Inc. Związki użyteczne jako inhibitory RIPK1
MX2024008648A (es) 2022-01-12 2024-09-23 Denali Therapeutics Inc Formas cristalinas de (s)-5-bencil-n-(5-metil-4-oxo-2,3,4,5-tetrah idropirido [3,2- b][1,4]oxacepin-3-il)-4h-1,2,4-triazol-3-carboxam ida.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
FR2601368B1 (fr) * 1986-07-08 1989-04-07 Synthelabo Derives de nitrofuranne, leur preparation et leur application en therapeutique.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329950B2 (en) 2005-07-06 2012-12-11 Sunovion Pharmaceuticals Inc. Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine
US8524950B2 (en) 2006-03-31 2013-09-03 Sunovion Pharmaceuticals Inc. Preparation of chiral amides and amines

Also Published As

Publication number Publication date
ES2081747A1 (es) 1996-03-01

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