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BR0015884A - Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados - Google Patents

Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados

Info

Publication number
BR0015884A
BR0015884A BR0015884-4A BR0015884A BR0015884A BR 0015884 A BR0015884 A BR 0015884A BR 0015884 A BR0015884 A BR 0015884A BR 0015884 A BR0015884 A BR 0015884A
Authority
BR
Brazil
Prior art keywords
formulations
dose inhalers
stable pharmaceutical
pharmaceutical solutions
metered dose
Prior art date
Application number
BR0015884-4A
Other languages
English (en)
Inventor
David Lewis
Gaetano Brambilla
David Ganderton
Brian Meakin
Alessandra Ferraris
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8163952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0015884(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BR0015884A publication Critical patent/BR0015884A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"FORMULAçõES DE SOLUçõES FARMACêUTICAS ESTáVEIS PARA INALADORES DE DOSE MEDIDA PRESSURIZADOS". Composição de solução de aerossol para uso em um inalador de acrossol compreende um material ativo, um propelente contendo um hidrofluoroalcano, um co-solvente e, opcionalmente, um componente de baixa volatilidade para aumentar o diâmetro aerodinâmico médio de massa (MMAD) das partículas de aerossol, mediante acionamento do inalador. A composição é estabilizada através do uso de uma pequena quantidade de ácido mineral e de uma lata adequada tendo suas superfícies metálicas internas feitas, parcial ou totalmente, de aço inoxidável, alumínio anodizado ou revestidas com um revestimento orgânico inerte.
BR0015884-4A 2000-05-22 2000-05-22 Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados BR0015884A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2000/004635 WO2001089480A1 (en) 2000-05-22 2000-05-22 Stable pharmaceutical solution formulations for pressurised metered dose inhalers

Publications (1)

Publication Number Publication Date
BR0015884A true BR0015884A (pt) 2003-07-08

Family

ID=8163952

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015884-4A BR0015884A (pt) 2000-05-22 2000-05-22 Formulações de soluções farmacêuticas estáveis para inaladores de dose medida pressurizados

Country Status (41)

Country Link
US (3) US6716414B2 (pt)
EP (4) EP2223682B1 (pt)
JP (1) JP5392880B2 (pt)
CN (1) CN1213732C (pt)
AR (1) AR029523A1 (pt)
AT (4) ATE415945T1 (pt)
AU (2) AU2000250701B2 (pt)
BE (1) BE2011C032I2 (pt)
BG (1) BG65883B1 (pt)
BR (1) BR0015884A (pt)
CA (1) CA2411047C (pt)
CY (6) CY1108833T1 (pt)
CZ (1) CZ303833B6 (pt)
DE (5) DE60144304D1 (pt)
DK (4) DK2223682T3 (pt)
DZ (1) DZ3358A1 (pt)
EA (1) EA005179B1 (pt)
EE (1) EE05167B1 (pt)
ES (4) ES2359991T3 (pt)
FR (1) FR11C0041I2 (pt)
HK (1) HK1058900A1 (pt)
HR (1) HRP20021025B1 (pt)
HU (2) HU230804B1 (pt)
IL (2) IL152955A0 (pt)
JO (1) JO2310B1 (pt)
LT (1) LTC1787639I2 (pt)
LU (1) LU91875I2 (pt)
ME (2) ME00220B (pt)
MX (1) MXPA02011414A (pt)
MY (2) MY127145A (pt)
NL (1) NL300393I2 (pt)
NO (3) NO342935B1 (pt)
PE (1) PE20011323A1 (pt)
PT (4) PT1787639E (pt)
SA (1) SA01220126B1 (pt)
SI (4) SI1466594T1 (pt)
SK (1) SK286694B6 (pt)
TN (1) TNSN01074A1 (pt)
TW (1) TWI284047B (pt)
UA (1) UA73986C2 (pt)
WO (1) WO2001089480A1 (pt)

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