BE858683A - AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION - Google Patents

AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION

Info

Publication number: BE858683A
Authority: BE; Belgium
Prior art keywords: azabicyclohexanes; preparation; methods
Prior art date: 1976-09-15

Application number

BE180894A

Other languages

French (fr)

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-15

Filing date

1977-09-14

Publication date

1978-03-14

1977-06-23 Priority claimed from US05/809,341 external-priority patent/US4118393A/en

1977-06-23 Priority claimed from US05/809,340 external-priority patent/US4118417A/en

1977-06-23 Priority claimed from US05/809,339 external-priority patent/US4131611A/en

1977-09-14 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1978-03-14 Publication of BE858683A publication Critical patent/BE858683A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BE180894A 1976-09-15 1977-09-14 AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION BE858683A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US72340276A	1976-09-15	1976-09-15
US05/809,341 US4118393A (en)	1977-06-23	1977-06-23	Phenyl azabicyclohexanones
US05/809,340 US4118417A (en)	1977-06-23	1977-06-23	Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,339 US4131611A (en)	1975-07-31	1977-06-23	Azabicyclohexanes

Publications (1)

Publication Number	Publication Date
BE858683A true BE858683A (en)	1978-03-14

Family

ID=27505564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE180894A BE858683A (en)	1976-09-15	1977-09-14	AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION

Country Status (16)

Country	Link
JP (1)	JPS5337656A (en)
AR (2)	AR220684A1 (en)
AT (2)	AT367036B (en)
AU (1)	AU519620B2 (en)
BE (1)	BE858683A (en)
CH (2)	CH637929A5 (en)
DD (1)	DD133943A5 (en)
DE (1)	DE2740562A1 (en)
DK (3)	DK146245C (en)
FR (1)	FR2375212A1 (en)
GR (1)	GR72713B (en)
HU (1)	HU177531B (en)
NL (1)	NL189041C (en)
PL (1)	PL115869B1 (en)
SE (2)	SE435384B (en)
YU (2)	YU39499B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6372919B1 (en)	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en)	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US8138377B2 (en)	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US8765801B2 (en)	2004-08-18	2014-07-01	Euthymics Bioscience, Inc.	Polymorphs of azabicyclohexane
US8877798B2 (en)	2005-07-27	2014-11-04	Neurovance, Inc.	1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9393204B2 (en)	2002-07-31	2016-07-19	Ebi Life Sciences, Inc.	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US9527813B2 (en)	2006-04-28	2016-12-27	Euthymics Bioscience, Inc.	Process for the synthesis of (+) and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
US12042481B2 (en)	2011-07-30	2024-07-23	Otsuka America Pharmaceutical, Inc.	Use of (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4183857A (en) *	1978-07-06	1980-01-15	Shell Oil Company	3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) *	1977-08-11	1986-12-31	American Cyanamid Co	Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) *	1978-06-27	1982-01-26	Janet A. Day	Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) *	1978-07-06	1980-09-30	Shell Oil Company	Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) *	1986-07-25	1988-02-10	東京電力株式会社	Shield excavator
JPH0658037B2 (en) *	1989-09-01	1994-08-03	日本鋼管株式会社	Shield excavator
BRPI0512182A (en) *	2004-07-22	2008-02-19	Wyeth Corp	Method for treating nervous system conditions and disorders
BRPI0512186A (en) *	2004-07-22	2008-02-19	Wyeth Corp	Method for the treatment of disorders and conditions of the nervous system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1351754A (en) *	1970-07-02	1974-05-01	Allen & Hanburys Ltd	Indenopyrrole derivatives

1977
- 1977-08-16 GR GR54169A patent/GR72713B/el unknown
- 1977-08-26 AR AR268968A patent/AR220684A1/en active
- 1977-09-01 AU AU28441/77A patent/AU519620B2/en not_active Ceased
- 1977-09-02 NL NLAANVRAGE7709691,A patent/NL189041C/en not_active IP Right Cessation
- 1977-09-08 DE DE19772740562 patent/DE2740562A1/en active Granted
- 1977-09-13 CH CH1118977A patent/CH637929A5/en not_active IP Right Cessation
- 1977-09-13 YU YU2174/77A patent/YU39499B/en unknown
- 1977-09-14 PL PL1977200831A patent/PL115869B1/en unknown
- 1977-09-14 HU HU77AE508A patent/HU177531B/en unknown
- 1977-09-14 DK DK407577A patent/DK146245C/en not_active IP Right Cessation
- 1977-09-14 AT AT0661577A patent/AT367036B/en not_active IP Right Cessation
- 1977-09-14 FR FR7727755A patent/FR2375212A1/en active Granted
- 1977-09-14 BE BE180894A patent/BE858683A/en not_active IP Right Cessation
- 1977-09-15 SE SE7710367A patent/SE435384B/en not_active IP Right Cessation
- 1977-09-15 DD DD77201039A patent/DD133943A5/en unknown
- 1977-09-16 JP JP11064777A patent/JPS5337656A/en active Granted
1978
- 1978-09-19 AR AR273764A patent/AR227507A1/en active
1980
- 1980-05-30 AT AT0288280A patent/AT367037B/en not_active IP Right Cessation
- 1980-10-16 DK DK438480A patent/DK438480A/en not_active Application Discontinuation
- 1980-10-16 DK DK438580A patent/DK438580A/en not_active Application Discontinuation
1982
- 1982-04-05 CH CH209382A patent/CH637931A5/en not_active IP Right Cessation
- 1982-06-03 SE SE8203437A patent/SE452610B/en not_active IP Right Cessation
- 1982-08-23 YU YU1885/82A patent/YU43523B/en unknown

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6372919B1 (en)	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en)	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US6716868B2 (en)	2001-08-24	2004-04-06	Dov Pharmaceutical Inc	(-)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor
US7041835B2 (en)	2001-08-24	2006-05-09	Dor Pharmaceutical, Inc.	(−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor
US7081471B2 (en)	2001-08-24	2006-07-25	Dov Pharmaceutical, Inc.	(-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor
US7098230B2 (en)	2001-08-24	2006-08-29	Dov Pharmaceutical, Inc.	(-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake inhibitor
US9393204B2 (en)	2002-07-31	2016-07-19	Ebi Life Sciences, Inc.	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US8765801B2 (en)	2004-08-18	2014-07-01	Euthymics Bioscience, Inc.	Polymorphs of azabicyclohexane
US9139521B2 (en)	2004-08-18	2015-09-22	Euthymics Bioscience, Inc.	Polymorphs of azabicyclohexane
US8877798B2 (en)	2005-07-27	2014-11-04	Neurovance, Inc.	1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9205074B2 (en)	2005-07-27	2015-12-08	Neurovance, Inc.	1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9737506B2 (en)	2005-07-27	2017-08-22	Neurovance, Inc.	1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US10039746B2 (en)	2005-07-27	2018-08-07	Otsuka America Pharmaceutical, Inc.	1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US9527813B2 (en)	2006-04-28	2016-12-27	Euthymics Bioscience, Inc.	Process for the synthesis of (+) and (−)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
US8138377B2 (en)	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US9597315B2 (en)	2007-06-06	2017-03-21	Euthymics Bioscience, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US12042481B2 (en)	2011-07-30	2024-07-23	Otsuka America Pharmaceutical, Inc.	Use of (1R,5S)-(+)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane in the treatment of conditions affected by monoamine neurotransmitters

Also Published As

Publication number	Publication date
GR72713B (en)	1983-12-01
DK438580A (en)	1980-10-16
AR227507A1 (en)	1982-11-15
CH637929A5 (en)	1983-08-31
PL115869B1 (en)	1981-05-30
NL7709691A (en)	1978-03-17
YU39499B (en)	1984-12-31
SE7710367L (en)	1978-03-16
DK438480A (en)	1980-10-16
YU217477A (en)	1983-01-21
HU177531B (en)	1981-11-28
AU519620B2 (en)	1981-12-17
JPS5337656A (en)	1978-04-06
SE452610B (en)	1987-12-07
AT367037B (en)	1982-05-25
FR2375212B1 (en)	1981-07-31
FR2375212A1 (en)	1978-07-21
AU2844177A (en)	1979-03-08
YU43523B (en)	1989-08-31
DK407577A (en)	1978-03-16
SE8203437L (en)	1982-06-03
DK146245B (en)	1983-08-08
ATA288280A (en)	1981-10-15
DD133943A5 (en)	1979-01-31
JPS6129341B2 (en)	1986-07-05
DK146245C (en)	1984-01-16
YU188582A (en)	1985-03-20
ATA661577A (en)	1981-10-15
NL189041B (en)	1992-07-16
NL189041C (en)	1992-12-16
PL200831A1 (en)	1980-02-11
DE2740562A1 (en)	1978-03-23
AT367036B (en)	1982-05-25
DE2740562C2 (en)	1989-05-03
CH637931A5 (en)	1983-08-31
AR220684A1 (en)	1980-11-28
SE435384B (en)	1984-09-24

Publication	Publication Date	Title
BE852510A (en)	1977-09-16	HENTRIACONTAPPTIDES AND METHODS FOR THEIR PREPARATION
FR2348970A1 (en)	1977-11-18	NEW ANTHELMINTICS AND METHODS FOR THEIR PREPARATION
FI783460A (en)	1979-06-02	VIRVELBAEDDFOERBRAENNING MED FOERTORKNING AV FUKTIG INMATNING UNDER ANVAENDANDE AV BAEDDSAND
FI770510A (en)	1978-08-18	ANORDINATION FOR PIPETTS AND PIPETTS
BE849794A (en)	1977-04-15	CARBOSTYRILE DERIVATIVES AND THEIR PREPARATION PROCESS
FR2275196A1 (en)	1976-01-16	NEW DIHYDROXY-1A, 24 CHOLECALCIFEROLS AND METHODS FOR THEIR PREPARATION
BE858683A (en)	1978-03-14	AZABICYCLOHEXANES AND METHODS FOR THEIR PREPARATION
FI780160A (en)	1978-07-20	APPARAT AV KONDENSTORKARTYP FOER AVFUKTNING AV LUFT
BE860737A (en)	1978-03-01	PIPERDINE COMPOUNDS AND THEIR PREPARATION.
BE855248A (en)	1977-11-30	ANHIDROTIC COMPOSITIONS AND METHODS
FI780477A (en)	1978-08-15	APPARAT FOER BELAEGGNING AV EN ROERLIG PAPPERSBANA
BE863702A (en)	1978-08-07	TETRAZOLYLCARBAMOYLQUINOLEINS AND THEIR PREPARATION
BE859221A (en)	1978-03-29	N-SUBSTITUTE BIS-CARBAMOYLSULFIDES AND THEIR PREPARATION
FR2345439A1 (en)	1977-10-21	DIHYDROOXADIAZINONES AND THEIR PREPARATION METHODS
BE856220A (en)	1977-12-28	POLYETHER-POLYUREIDES AND PROCESS FOR THEIR PREPARATION
BE857708A (en)	1978-02-13	(((DIPHENYLMETHYL) -4 PIPERIDINO) METHYL) -4 BENZENAMINES AND METHODS FOR THEIR PREPARATION
FR2349576A1 (en)	1977-11-25	INDAZOLYL- (4) -OXY-PROPANOLAMINES AND METHODS FOR THEIR PREPARATION
FR2323384A1 (en)	1977-04-08	NEW PENICILLINS AND METHODS FOR THEIR PREPARATION
BE869352A (en)	1979-01-29	NEW NITROSOUREES AND THEIR APPLICATION
BE866327A (en)	1978-10-25	ISOINDOLINES AND THEIR PREPARATION
FI780598A (en)	1978-08-24	APPARAT FOER KONVERTERING AV AVFALLSMATERIAL
BE863744A (en)	1978-05-29	CONDENSED QUINAZOLINES AND METHODS FOR THEIR PREPARATION
BE838809A (en)	1976-08-20	PENTAFLUOROETHYLARYLAMINES AND THEIR PREPARATION METHODS
BE872342A (en)	1979-05-28	SYMPATHICOMIMETIC PHENOXY-ALCANOL-AMINES AND METHODS FOR THEIR PREPARATION
FR2318174A1 (en)	1977-02-11	DIEPOXY-ANDROSTANES AND THEIR PREPARATION

Legal Events

Date	Code	Title	Description
1993-03-31	RE	Patent lapsed	Owner name: AMERICAN CYANAMID CY Effective date: 19920930

Date

Code

Title

Description

1993-03-31

Patent lapsed

Owner name: AMERICAN CYANAMID CY

Effective date: 19920930