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NL189041C - METHOD FOR PREPARING OPTICALLY ACTIVE AZABICYCLOHEXANES AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION - Google Patents

METHOD FOR PREPARING OPTICALLY ACTIVE AZABICYCLOHEXANES AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION

Info

Publication number
NL189041C
NL189041C NLAANVRAGE7709691,A NL7709691A NL189041C NL 189041 C NL189041 C NL 189041C NL 7709691 A NL7709691 A NL 7709691A NL 189041 C NL189041 C NL 189041C
Authority
NL
Netherlands
Prior art keywords
preparing
azabicyclohexanes
optically active
pharmaceutical preparation
preparing optically
Prior art date
Application number
NLAANVRAGE7709691,A
Other languages
Dutch (nl)
Other versions
NL189041B (en
NL7709691A (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of NL7709691A publication Critical patent/NL7709691A/en
Publication of NL189041B publication Critical patent/NL189041B/en
Application granted granted Critical
Publication of NL189041C publication Critical patent/NL189041C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/40Unsaturated compounds containing halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/28Unsaturated compounds polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/34Unsaturated compounds containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NLAANVRAGE7709691,A 1976-09-15 1977-09-02 METHOD FOR PREPARING OPTICALLY ACTIVE AZABICYCLOHEXANES AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION NL189041C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones

Publications (3)

Publication Number Publication Date
NL7709691A NL7709691A (en) 1978-03-17
NL189041B NL189041B (en) 1992-07-16
NL189041C true NL189041C (en) 1992-12-16

Family

ID=27505564

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7709691,A NL189041C (en) 1976-09-15 1977-09-02 METHOD FOR PREPARING OPTICALLY ACTIVE AZABICYCLOHEXANES AND METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION

Country Status (16)

Country Link
JP (1) JPS5337656A (en)
AR (2) AR220684A1 (en)
AT (2) AT367036B (en)
AU (1) AU519620B2 (en)
BE (1) BE858683A (en)
CH (2) CH637929A5 (en)
DD (1) DD133943A5 (en)
DE (1) DE2740562A1 (en)
DK (3) DK146245C (en)
FR (1) FR2375212A1 (en)
GR (1) GR72713B (en)
HU (1) HU177531B (en)
NL (1) NL189041C (en)
PL (1) PL115869B1 (en)
SE (2) SE435384B (en)
YU (2) YU39499B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (en) * 1986-07-25 1988-02-10 東京電力株式会社 Shield excavator
JPH0658037B2 (en) * 1989-09-01 1994-08-03 日本鋼管株式会社 Shield excavator
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
BRPI0512182A (en) * 2004-07-22 2008-02-19 Wyeth Corp Method for treating nervous system conditions and disorders
EP1773320A1 (en) * 2004-07-22 2007-04-18 Wyeth Method for treating nervous system disorders and conditions
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
CN101272781A (en) 2005-07-27 2008-09-24 多夫药品公司 Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
FR2375212A1 (en) 1978-07-21
CH637929A5 (en) 1983-08-31
SE8203437L (en) 1982-06-03
AT367037B (en) 1982-05-25
AU2844177A (en) 1979-03-08
YU39499B (en) 1984-12-31
FR2375212B1 (en) 1981-07-31
NL189041B (en) 1992-07-16
JPS5337656A (en) 1978-04-06
AT367036B (en) 1982-05-25
DK438480A (en) 1980-10-16
AR227507A1 (en) 1982-11-15
YU217477A (en) 1983-01-21
DK146245B (en) 1983-08-08
AR220684A1 (en) 1980-11-28
SE435384B (en) 1984-09-24
YU188582A (en) 1985-03-20
SE452610B (en) 1987-12-07
AU519620B2 (en) 1981-12-17
DE2740562C2 (en) 1989-05-03
NL7709691A (en) 1978-03-17
PL200831A1 (en) 1980-02-11
ATA288280A (en) 1981-10-15
JPS6129341B2 (en) 1986-07-05
DK438580A (en) 1980-10-16
ATA661577A (en) 1981-10-15
SE7710367L (en) 1978-03-16
DD133943A5 (en) 1979-01-31
DK146245C (en) 1984-01-16
BE858683A (en) 1978-03-14
DE2740562A1 (en) 1978-03-23
YU43523B (en) 1989-08-31
PL115869B1 (en) 1981-05-30
DK407577A (en) 1978-03-16
CH637931A5 (en) 1983-08-31
GR72713B (en) 1983-12-01
HU177531B (en) 1981-11-28

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Legal Events

Date Code Title Description
V2 Lapsed due to non-payment of the last due maintenance fee for the patent application