ATE92767T1 - Auf tocopherol basierte arzneimittelsysteme. - Google Patents
Auf tocopherol basierte arzneimittelsysteme.Info
- Publication number
- ATE92767T1 ATE92767T1 AT88909942T AT88909942T ATE92767T1 AT E92767 T1 ATE92767 T1 AT E92767T1 AT 88909942 T AT88909942 T AT 88909942T AT 88909942 T AT88909942 T AT 88909942T AT E92767 T1 ATE92767 T1 AT E92767T1
- Authority
- AT
- Austria
- Prior art keywords
- composition
- stabilizer
- organic acid
- acid derivative
- based drug
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title 1
- 229960001295 tocopherol Drugs 0.000 title 1
- 229930003799 tocopherol Natural products 0.000 title 1
- 235000010384 tocopherol Nutrition 0.000 title 1
- 239000011732 tocopherol Substances 0.000 title 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- -1 organic acid derivative of alpha tocopherol Chemical class 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000012867 bioactive agent Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960001416 pilocarpine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11026187A | 1987-10-19 | 1987-10-19 | |
| EP88909942A EP0382779B1 (de) | 1987-10-19 | 1988-10-19 | Auf tocopherol basierte arzneimittelsysteme |
| PCT/US1988/003752 WO1989003689A1 (en) | 1987-10-19 | 1988-10-19 | Tocopherol-based pharmaceutical systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE92767T1 true ATE92767T1 (de) | 1993-08-15 |
Family
ID=22332058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88909942T ATE92767T1 (de) | 1987-10-19 | 1988-10-19 | Auf tocopherol basierte arzneimittelsysteme. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0382779B1 (de) |
| JP (1) | JP2921792B2 (de) |
| AT (1) | ATE92767T1 (de) |
| CA (1) | CA1333360C (de) |
| DE (1) | DE3883246T2 (de) |
| WO (1) | WO1989003689A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2657526B1 (fr) * | 1990-01-31 | 1994-10-28 | Lvmh Rech | Utilisation d'un phosphate d'alpha-tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, dermatologiques, ou pharmaceutiques; compositions ainsi obtenues. |
| US5179122A (en) * | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
| FR2679904A1 (fr) * | 1991-08-01 | 1993-02-05 | Lvmh Rech | Utilisation d'un phosphate de tocopherol, ou de l'un de ses derives, pour la preparation de compositions cosmetiques, ou pharmaceutiques et compositions ainsi obtenues. |
| JP2811036B2 (ja) * | 1992-05-26 | 1998-10-15 | 参天製薬株式会社 | ビタミンｅ点眼剤 |
| CN1129400A (zh) * | 1994-05-06 | 1996-08-21 | 阿尔康实验室公司 | 维生素e生育酚衍生物在眼科组合物中的应用 |
| GB9409778D0 (en) * | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
| GB2317562B (en) * | 1995-07-20 | 1999-08-18 | Danbiosyst Uk | Lipid vehicle drug delivery composition containing vitamin E |
| GB9514878D0 (en) * | 1995-07-20 | 1995-09-20 | Danbiosyst Uk | Vitamin E as a solubilizer for drugs contained in lipid vehicles |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| JP5246182B2 (ja) * | 2010-02-24 | 2013-07-24 | ライオン株式会社 | 点眼剤、防腐剤及び防腐力向上剤 |
| JP6122646B2 (ja) * | 2013-01-23 | 2017-04-26 | 昭和電工株式会社 | 皮膚外用剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608075A (en) * | 1969-07-28 | 1971-09-21 | American Home Prod | Compositions and methods of treating the menopausal syndrome |
| JPS5659710A (en) * | 1979-10-22 | 1981-05-23 | Eisai Co Ltd | Preventive and remedy for psoriasis |
| US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
| JPS6295134A (ja) * | 1985-10-21 | 1987-05-01 | Nippon Saafuakutanto Kogyo Kk | リポソ−ムの製造法 |
| AU596581B2 (en) * | 1986-04-15 | 1990-05-10 | Sansho Seiyaku Co., Ltd. | Topical agents for inhibiting the melanin generation |
-
1988
- 1988-10-19 CA CA000580562A patent/CA1333360C/en not_active Expired - Fee Related
- 1988-10-19 AT AT88909942T patent/ATE92767T1/de not_active IP Right Cessation
- 1988-10-19 WO PCT/US1988/003752 patent/WO1989003689A1/en active IP Right Grant
- 1988-10-19 DE DE88909942T patent/DE3883246T2/de not_active Expired - Fee Related
- 1988-10-19 EP EP88909942A patent/EP0382779B1/de not_active Expired - Lifetime
- 1988-10-19 JP JP63509168A patent/JP2921792B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03500651A (ja) | 1991-02-14 |
| DE3883246T2 (de) | 1993-12-02 |
| EP0382779A4 (en) | 1991-01-09 |
| EP0382779A1 (de) | 1990-08-22 |
| DE3883246D1 (de) | 1993-09-16 |
| EP0382779B1 (de) | 1993-08-11 |
| WO1989003689A1 (en) | 1989-05-05 |
| CA1333360C (en) | 1994-12-06 |
| JP2921792B2 (ja) | 1999-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |