ATE500323T1 - Subtilisin-variante - Google Patents
Subtilisin-varianteInfo
- Publication number
- ATE500323T1 ATE500323T1 AT01923084T AT01923084T ATE500323T1 AT E500323 T1 ATE500323 T1 AT E500323T1 AT 01923084 T AT01923084 T AT 01923084T AT 01923084 T AT01923084 T AT 01923084T AT E500323 T1 ATE500323 T1 AT E500323T1
- Authority
- AT
- Austria
- Prior art keywords
- homologues
- new
- subtilisin variant
- proteins
- subtilisin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/6408—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19414300P | 2000-04-03 | 2000-04-03 | |
PCT/US2001/010781 WO2001075087A2 (en) | 2000-04-03 | 2001-04-02 | Subtilisin variants |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE500323T1 true ATE500323T1 (de) | 2011-03-15 |
Family
ID=22716459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01923084T ATE500323T1 (de) | 2000-04-03 | 2001-04-02 | Subtilisin-variante |
Country Status (8)
Country | Link |
---|---|
US (4) | US6902922B2 (de) |
EP (1) | EP1287123B1 (de) |
JP (1) | JP2004508011A (de) |
AT (1) | ATE500323T1 (de) |
AU (4) | AU4981101A (de) |
CA (1) | CA2405063C (de) |
DE (1) | DE60144145D1 (de) |
WO (1) | WO2001075087A2 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
DE60144145D1 (de) * | 2000-04-03 | 2011-04-14 | Maxygen Inc | Subtilisin-variante |
EP1280919A2 (de) * | 2000-04-28 | 2003-02-05 | Novozymes A/S | Varianten eines lipolytischen enzyms |
US7109016B2 (en) * | 2000-08-21 | 2006-09-19 | Novozymes A/S | Subtilase enzymes |
AU758744B2 (en) * | 2000-10-31 | 2003-03-27 | F. Hoffmann-La Roche Ag | Methods for the analysis of non-proteinaceous components using a protease from a bacillus strain |
DE10121463A1 (de) * | 2001-05-02 | 2003-02-27 | Henkel Kgaa | Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten |
DK200101090A (da) | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
DE10162727A1 (de) * | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
WO2003062380A2 (en) * | 2002-01-16 | 2003-07-31 | Genencor International, Inc. | Multiply-substituted protease variants |
US7306937B2 (en) * | 2002-01-16 | 2007-12-11 | Genencor International, Inc. | Multiply-substituted protease variants |
US7888093B2 (en) | 2002-11-06 | 2011-02-15 | Novozymes A/S | Subtilase variants |
EP1623029B1 (de) * | 2003-05-07 | 2008-09-03 | Novozymes A/S | Enzymvarianten von subtilisin (subtilasen) |
US9695251B2 (en) | 2003-10-31 | 2017-07-04 | The Regents Of The University Of California | Activatable cell penetrating peptides with quenched fluorophores |
CN1969042B (zh) * | 2004-04-02 | 2014-09-24 | 诺维信公司 | 具有改变的免疫原性的枯草杆菌酶变体 |
US20090060933A1 (en) * | 2004-06-14 | 2009-03-05 | Estell David A | Proteases producing an altered immunogenic response and methods of making and using the same |
CN101460618A (zh) | 2006-04-20 | 2009-06-17 | 诺维信公司 | 对蛋渍具有改进的洗涤性能的洒维奈斯变体 |
US7802883B2 (en) * | 2007-12-20 | 2010-09-28 | Johnson & Johnson Vision Care, Inc. | Cosmetic contact lenses having a sparkle effect |
JP2011524166A (ja) * | 2008-06-06 | 2011-09-01 | ダニスコ・ユーエス・インク | 変異体微生物プロテアーゼを含む組成物及び方法 |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
DK2285958T3 (en) | 2008-06-13 | 2016-03-29 | Codexis Inc | Method for synthesizing polynucleotides |
DK3301208T3 (da) | 2009-09-18 | 2020-12-14 | Codexis Inc | Reduceret codon-mutagenese |
US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
JP2016523552A (ja) | 2013-07-10 | 2016-08-12 | ノバルティス アーゲー | 多重プロテアーゼ欠損糸状菌細胞及びその使用方法 |
US10513724B2 (en) | 2014-07-21 | 2019-12-24 | Glykos Finland Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
SG11201808957UA (en) | 2016-05-05 | 2018-11-29 | Codexis Inc | Penicillin-g acylases |
EP3878967A3 (de) | 2017-02-03 | 2021-12-08 | Codexis, Inc. | Manipulierte glycosyltransferasen und verfahren zur steviol-glycosid-glucosylierung |
BR112019016634A2 (pt) | 2017-02-13 | 2020-04-07 | Codexis Inc | polipeptídeos, sequência de polinucleotídeos modificados por engenharia, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo de fenilalanina amônia liase modificado por engenharia em uma célula hospedeira e para tratar e/ou prevenir os sintomas de fenilcetonúria em um indivíduo, composição, e, uso |
US11021729B2 (en) | 2017-04-27 | 2021-06-01 | Codexis, Inc. | Ketoreductase polypeptides and polynucleotides |
HUE055411T2 (hu) | 2017-05-08 | 2021-11-29 | Codexis Inc | Génmódosított ligáz variánsok |
EP3638688A4 (de) | 2017-06-14 | 2021-07-07 | Codexis, Inc. | Manipulierte transaminase-polypeptide für industrielle biokatalyse |
WO2019005337A1 (en) | 2017-06-27 | 2019-01-03 | Codexis, Inc. | PENICILLIN G ACYLASES |
US11319531B2 (en) | 2017-11-07 | 2022-05-03 | Codexis, Inc. | Transglutaminase variants |
EP3724325A4 (de) | 2017-12-13 | 2021-11-24 | Codexis, Inc. | Carboxyesterase-polypeptide zur amidkopplung |
US10900055B2 (en) | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
MX2021000323A (es) | 2018-07-09 | 2021-03-25 | Codexis Inc | Enzimas de variante de pantotenato quinasa modificadas geneticamente. |
KR20210031933A (ko) | 2018-07-09 | 2021-03-23 | 코덱시스, 인코포레이티드 | 조작된 포스포펜토뮤타제 변이체 효소 |
US11162105B2 (en) | 2018-07-09 | 2021-11-02 | Codexis, Inc. | Engineered purine nucleoside phosphorylase variant enzymes |
CA3103721A1 (en) | 2018-07-09 | 2020-01-16 | Codexis, Inc. | Engineered deoxyribose-phosphate aldolases |
JP7491587B2 (ja) | 2018-07-09 | 2024-05-28 | コデクシス, インコーポレイテッド | 操作されたガラクトースオキシダーゼ改変体酵素 |
WO2020013951A1 (en) | 2018-07-12 | 2020-01-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
EP3830106A4 (de) | 2018-07-30 | 2022-07-06 | Codexis, Inc. | Manipulierte glycosyltransferasen und verfahren zur steviol-glycosid-glucosylierung |
CA3116590A1 (en) | 2018-10-29 | 2020-05-07 | Codexis, Inc. | Engineered dna polymerase variants |
EP3893860A4 (de) | 2018-12-14 | 2023-03-29 | Codexis, Inc. | Manipulierte tyrosin-ammoniak-lyase |
JP7245676B2 (ja) * | 2019-03-11 | 2023-03-24 | 花王株式会社 | 変異プロテアーゼ |
KR20220106738A (ko) | 2019-08-30 | 2022-07-29 | 코덱시스, 인코포레이티드 | 조작된 리파제 변이체 |
WO2021050348A1 (en) | 2019-09-12 | 2021-03-18 | Codexis, Inc. | Peroxidase activity towards 10-acetyl-3,7-dihydroxyphenoxazine |
AU2020408066A1 (en) | 2019-12-20 | 2022-06-30 | Codexis, Inc. | Engineered acid alpha-glucosidase variants |
US11788071B2 (en) | 2020-04-10 | 2023-10-17 | Codexis, Inc. | Engineered transaminase polypeptides |
WO2022047264A1 (en) | 2020-08-28 | 2022-03-03 | Codexis, Inc. | Engineered amylase variants |
CN117098847A (zh) | 2020-08-28 | 2023-11-21 | 科德克希思公司 | 工程化蛋白酶变体 |
JP2023542006A (ja) * | 2020-09-21 | 2023-10-04 | バイエル クロップサイエンス エルピー | 新規なセリンプロテアーゼ |
US11898174B2 (en) | 2020-12-18 | 2024-02-13 | Codexis, Inc. | Engineered uridine phosphorylase variant enzymes |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
EP4314261A1 (de) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Manipulierte enzyme mit acetatkinasevarianten |
EP4314262A1 (de) | 2021-04-02 | 2024-02-07 | Codexis, Inc. | Manipulierte guanylatkinase-variantenenzyme |
WO2022212832A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered cyclic gmp-amp synthase (cgas) variant enzymes |
CA3214972A1 (en) | 2021-04-02 | 2022-10-06 | Codexis, Inc. | Engineered adenylate kinase variant enzymes |
WO2022246126A1 (en) | 2021-05-21 | 2022-11-24 | Codexis, Inc. | Engineered methionine gamma lyase variants |
EP4416278A1 (de) | 2021-10-15 | 2024-08-21 | Codexis, Inc. | Manipulierte dna-polymerasevarianten |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US49827A (en) * | 1865-09-05 | Improvement in machines for making cement pipe | ||
PT86864B (pt) * | 1987-02-27 | 1992-05-29 | Gist Brocades Nv | Processo para clonagem molecular e expressao de genes que codificam para enzimas proteoliticas |
DK6488D0 (da) * | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
ATE168130T1 (de) * | 1991-05-01 | 1998-07-15 | Novo Nordisk As | Stabilisierte enzyme und waschmittelzusammensetzungen |
US5340735A (en) * | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
US5316935A (en) | 1992-04-06 | 1994-05-31 | California Institute Of Technology | Subtilisin variants suitable for hydrolysis and synthesis in organic media |
EP0717778B1 (de) * | 1992-07-17 | 2007-10-17 | Genencor International, Inc. | Hochalkalische serinproteasen |
DE69331907T2 (de) * | 1992-09-24 | 2002-09-05 | Genencor International, Inc. | Neue alkalische proteasen enthaltende reinigungsmittelzusammensetzungen |
WO1995010591A1 (en) * | 1993-10-14 | 1995-04-20 | The Procter & Gamble Company | Protease-containing cleaning compositions |
CN1177921C (zh) * | 1993-10-14 | 2004-12-01 | 普罗格特-甘布尔公司 | 含有蛋白酶的漂白组合物 |
US5972042A (en) | 1995-12-22 | 1999-10-26 | Novo Nordisk A/S | Method for dyeing a material with a dyeing system which contains an enzymatic oxidizing agent |
BR9712878A (pt) * | 1996-11-04 | 2000-02-01 | Novo Nordisk As | Variante de enzima subtilase, processos para a identificação de uma variante de protease apresentando estabilidade autoproteolìtica e paraq a produção de uma enzima subtilase mutante e de uma variante de subtilase, sequência de dna, vetor, célula hospedeira microbiana, composição e uso de uma variante de subtilase. |
MA24811A1 (fr) * | 1997-10-23 | 1999-12-31 | Procter & Gamble | Compositions de lavage contenant des variantes de proteases multisubstituees |
US6777218B1 (en) * | 2000-03-14 | 2004-08-17 | Novozymes A/S | Subtilase enzymes having an improved wash performance on egg stains |
DE60144145D1 (de) * | 2000-04-03 | 2011-04-14 | Maxygen Inc | Subtilisin-variante |
DK200101090A (da) * | 2001-07-12 | 2001-08-16 | Novozymes As | Subtilase variants |
DE10162728A1 (de) * | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
-
2001
- 2001-04-02 DE DE60144145T patent/DE60144145D1/de not_active Expired - Lifetime
- 2001-04-02 WO PCT/US2001/010781 patent/WO2001075087A2/en active Application Filing
- 2001-04-02 JP JP2001572961A patent/JP2004508011A/ja active Pending
- 2001-04-02 AU AU4981101A patent/AU4981101A/xx active Pending
- 2001-04-02 US US09/824,893 patent/US6902922B2/en not_active Expired - Fee Related
- 2001-04-02 AT AT01923084T patent/ATE500323T1/de not_active IP Right Cessation
- 2001-04-02 EP EP01923084A patent/EP1287123B1/de not_active Expired - Lifetime
- 2001-04-02 AU AU2001249811A patent/AU2001249811B2/en not_active Ceased
- 2001-04-02 CA CA2405063A patent/CA2405063C/en not_active Expired - Fee Related
-
2003
- 2003-12-15 US US10/736,997 patent/US7220566B2/en not_active Expired - Fee Related
-
2006
- 2006-09-08 AU AU2006208427A patent/AU2006208427B2/en not_active Ceased
-
2007
- 2007-04-17 US US11/736,322 patent/US7605115B2/en not_active Expired - Fee Related
-
2009
- 2009-09-18 US US12/562,517 patent/US20100105599A1/en not_active Abandoned
- 2009-12-23 AU AU2009251169A patent/AU2009251169A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7220566B2 (en) | 2007-05-22 |
CA2405063C (en) | 2013-06-04 |
WO2001075087A3 (en) | 2002-12-19 |
US20030049827A1 (en) | 2003-03-13 |
AU2006208427A1 (en) | 2006-09-28 |
EP1287123B1 (de) | 2011-03-02 |
WO2001075087A8 (en) | 2001-12-27 |
DE60144145D1 (de) | 2011-04-14 |
AU2001249811B2 (en) | 2006-06-08 |
JP2004508011A (ja) | 2004-03-18 |
US7605115B2 (en) | 2009-10-20 |
WO2001075087A2 (en) | 2001-10-11 |
AU2009251169A1 (en) | 2010-01-21 |
US20100105599A1 (en) | 2010-04-29 |
EP1287123A2 (de) | 2003-03-05 |
AU2006208427B2 (en) | 2009-10-01 |
CA2405063A1 (en) | 2001-10-11 |
US20070270574A1 (en) | 2007-11-22 |
US6902922B2 (en) | 2005-06-07 |
US20040203130A1 (en) | 2004-10-14 |
AU4981101A (en) | 2001-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60144145D1 (de) | Subtilisin-variante | |
WO2002006457A3 (en) | Novel lipase genes | |
DK1210411T3 (da) | Sammensætninger og fremgangsmåder til forbedret celledyrkning | |
DE60127441D1 (de) | Dipeptidylpeptidasen | |
DE69942459D1 (de) | Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung | |
AR006188A1 (es) | "composicion farmaceutica para inhibir la actividad de serinproteasa, metodo in vitro para inhibir la actividad de serinproteasa y metodo para preparar dicha composicion". | |
DE60037450D1 (de) | Funf-helix protein | |
WO2002031134A3 (en) | Novel serine protease genes related to dppiv | |
ATE400656T1 (de) | Mini-dystrophin nukleinsäure- und peptidsequenzen | |
DE50112802D1 (de) | Peptide, deren herstellung und verwendung zur bindung von immunglobulinen | |
DK1131444T3 (da) | Polypeptider med lysophospholipase aktivitet og nucleinsyre som koder for disse | |
DK0981630T3 (da) | Polypeptider med prolyldipeptidylaminopeptidaseaktivitet og nukleinsyrer, der koder for samme | |
ATE474926T1 (de) | Verwendung von clya hemolysin fur ausscheidung von fusionprotein | |
WO2001025438A3 (en) | Ifn-alpha homologues | |
ATE439441T1 (de) | Veränderte, fluoreszierende proteine | |
DK1082423T3 (da) | Cyclin E2-gener og -proteiner | |
DK0939769T3 (da) | Vertebrat-Smoothened-proteiner | |
ATE309370T1 (de) | Retinoid-metabolisierendes protein | |
SE9602822D0 (sv) | New receptor | |
AU2001238064A1 (en) | 18477, a human protein kinase and uses therefor | |
WO2001064912A3 (en) | Triazine degrading enzymes | |
WO2002062964A3 (en) | Ap1 amine oxidase variants | |
WO2001040257A3 (en) | Modified il-12 subunits and nucleic acids encoding them | |
WO2001096593A3 (en) | Novel motor proteins and methods for their use | |
WO2002012541A3 (en) | Novel motor proteins and methods for their use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |