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ATE555774T1 - Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats - Google Patents

Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats

Info

Publication number
ATE555774T1
ATE555774T1 AT06776126T AT06776126T ATE555774T1 AT E555774 T1 ATE555774 T1 AT E555774T1 AT 06776126 T AT06776126 T AT 06776126T AT 06776126 T AT06776126 T AT 06776126T AT E555774 T1 ATE555774 T1 AT E555774T1
Authority
AT
Austria
Prior art keywords
granule
producing
drying process
spray drying
carnitine powder
Prior art date
Application number
AT06776126T
Other languages
English (en)
Inventor
Max Baumgartner
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of ATE555774T1 publication Critical patent/ATE555774T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/105Aliphatic or alicyclic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K40/00Shaping or working-up of animal feeding-stuffs
    • A23K40/10Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1664Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/007Carnitine; Butyrobetaine; Crotonobetaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Fodder In General (AREA)
  • General Preparation And Processing Of Foods (AREA)
AT06776126T 2005-07-05 2006-07-05 Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats ATE555774T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05014529 2005-07-05
PCT/EP2006/006551 WO2007003425A2 (en) 2005-07-05 2006-07-05 Spray-drying process for producing a dry carnitine powder or granulate

Publications (1)

Publication Number Publication Date
ATE555774T1 true ATE555774T1 (de) 2012-05-15

Family

ID=37562145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06776126T ATE555774T1 (de) 2005-07-05 2006-07-05 Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats

Country Status (11)

Country Link
US (1) US9084431B2 (de)
EP (1) EP1901715B1 (de)
JP (1) JP5149172B2 (de)
KR (1) KR101327700B1 (de)
CN (2) CN101912045B (de)
AT (1) ATE555774T1 (de)
AU (1) AU2006265280B2 (de)
BR (1) BRPI0612611A2 (de)
CA (1) CA2611901C (de)
ES (1) ES2385046T3 (de)
WO (1) WO2007003425A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5463526B2 (ja) * 2008-03-21 2014-04-09 国立大学法人東京海洋大学 健康機能成分を吸着・濃縮した乾燥脱脂穀類糠、該糠から調製した健康機能成分の濃縮物、及びそれらの製造方法
EP2335495A1 (de) 2009-12-11 2011-06-22 Lonza Ltd. Carnitin-Granulat und Verfahren zu dessen Herstellung
PL2729015T3 (pl) * 2011-07-08 2019-07-31 Purac Biochem Bv Aktywna formulacja do stosowania w produktach paszowych
WO2014076110A1 (en) 2012-11-16 2014-05-22 Lonza Ltd. Methods for decolorizing compositions comprising betaines
KR101721145B1 (ko) * 2015-07-29 2017-03-29 제너럴바이오(주) L-카르니틴 구연산 마그네슘을 포함하는 배변촉진 겸용 다이어트용 식품 조성물
CN106957238A (zh) * 2017-04-19 2017-07-18 黄冈华阳药业有限公司 一种肉碱的制备工艺
JP7240098B2 (ja) * 2018-01-17 2023-03-15 昭和産業株式会社 飼料原料及び飼料
CN111601512B (zh) * 2019-03-06 2023-11-17 彭险峰 γ-季铵基丁酸酯类化合物在制备动物饲料添加剂中的应用
CN111838421B (zh) * 2020-07-27 2023-04-21 中国科学院天津工业生物技术研究所 一种从发酵液中制备5-氨基乙酰丙酸的方法及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150688B1 (de) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salze von L-Carnitin und Alkanoyl-L-Carnitinen sowie Verfahren zur Herstellung derselben
FI86889C (fi) 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
US4751182A (en) * 1984-04-20 1988-06-14 Wisconsin Alumni Research Foundation Process for preparing L-carnitine from DL-carnitine
CA2018137C (en) 1989-06-14 2000-01-11 Thomas Scholl L-carnitine magnesium citrate
ATE122540T1 (de) 1989-07-31 1995-06-15 Univ Georgia Res Found Karnitindiät für ausgewachsene schweine.
JPH03120211A (ja) * 1989-10-04 1991-05-22 Earth Chem Corp Ltd 粒状カルニチン製剤
US5073376A (en) 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
PL180300B1 (pl) 1993-10-08 2001-01-31 Lonza Ag wektor zawierajacy taki fragment DNA, a takze mikroorganizmzawierajacy wskazany fragment DNA badz wektor oraz biotechnologiczny sposób wytwarzania L-karnityny PL PL PL PL PL
JPH0812569A (ja) * 1994-06-24 1996-01-16 Takeda Chem Ind Ltd 塩化カルニチン吸着固形物
ES2156381T3 (es) * 1996-05-31 2001-06-16 Sigma Tau Ind Farmaceuti Sales estables no higroscopicas de l(-)carnitina y alcanoil-l(-)carnitinas, un procedimiento para su preparacion y composiciones solidas, administrables por via oral, que contienen tales sales.
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
JP4452341B2 (ja) * 1999-01-13 2010-04-21 雪印乳業株式会社 L−カルニチン剤
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
DK1218001T3 (da) * 1999-09-03 2009-04-14 Sigma Tau Healthscience Spa Ultrafint L-carnitin, fremgangsmåder til fremstilling deraf, sammensætninger indeholdende det og fremgangsmåder til anvendelse deraf
ATE295690T1 (de) 2000-08-29 2005-06-15 Lonza Ag Verfahren zur herstellung einer granulierbaren mischung und carnitin-magnesium-hydroxycitrat
CN1203776C (zh) * 2000-12-07 2005-06-01 东北制药总厂 左旋肉碱饲料添加剂及其制备方法
DK1370663T3 (da) 2001-01-31 2007-07-02 Lonza Ag Mikrobiologisk metode til fremstilling af L-carnitin
US7169770B2 (en) 2001-04-24 2007-01-30 Lonza Ltd. Method of enhancing reproductive performance in sows
WO2003009854A1 (en) 2001-07-20 2003-02-06 Lonza Ag Lipid lowering composition comprising carnitine and phytosterol
US20030235646A1 (en) 2002-03-15 2003-12-25 Lonza Inc. Method for improving quality of meat by supplementing pig diets and concentrates used therefor

Also Published As

Publication number Publication date
CN101912045B (zh) 2013-07-31
AU2006265280A1 (en) 2007-01-11
KR20080030650A (ko) 2008-04-04
EP1901715A2 (de) 2008-03-26
EP1901715B1 (de) 2012-05-02
WO2007003425A3 (en) 2007-03-08
US9084431B2 (en) 2015-07-21
US20090082449A1 (en) 2009-03-26
WO2007003425A2 (en) 2007-01-11
AU2006265280B2 (en) 2011-07-14
KR101327700B1 (ko) 2013-11-11
CA2611901C (en) 2012-12-11
JP2009500026A (ja) 2009-01-08
CN101912045A (zh) 2010-12-15
CA2611901A1 (en) 2007-01-11
ES2385046T3 (es) 2012-07-17
BRPI0612611A2 (pt) 2010-12-07
CN101212956A (zh) 2008-07-02
JP5149172B2 (ja) 2013-02-20

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