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IT1305308B1 - Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione - Google Patents

Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione

Info

Publication number
IT1305308B1
IT1305308B1 IT1999RM000189A ITRM990189A IT1305308B1 IT 1305308 B1 IT1305308 B1 IT 1305308B1 IT 1999RM000189 A IT1999RM000189 A IT 1999RM000189A IT RM990189 A ITRM990189 A IT RM990189A IT 1305308 B1 IT1305308 B1 IT 1305308B1
Authority
IT
Italy
Prior art keywords
carnitine
alcanoyl
production
particularly suitable
content
Prior art date
Application number
IT1999RM000189A
Other languages
English (en)
Inventor
Ken Hassen
Original Assignee
Biosint S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999RM000189A priority Critical patent/IT1305308B1/it
Application filed by Biosint S P A filed Critical Biosint S P A
Priority to IL14495700A priority patent/IL144957A0/xx
Priority to DK00917258T priority patent/DK1171111T3/da
Priority to AT00917258T priority patent/ATE238784T1/de
Priority to PT00917258T priority patent/PT1171111E/pt
Priority to SI200030128T priority patent/SI1171111T1/xx
Priority to DE60002454T priority patent/DE60002454T2/de
Priority to AU38344/00A priority patent/AU780413B2/en
Priority to TR2001/02802T priority patent/TR200102802T2/xx
Priority to PCT/IT2000/000097 priority patent/WO2000057873A2/en
Priority to PL350908A priority patent/PL207961B1/pl
Priority to EP00917258A priority patent/EP1171111B1/en
Priority to SK1159-2001A priority patent/SK285565B6/sk
Priority to ES00917258T priority patent/ES2197867T3/es
Priority to JP2000607624A priority patent/JP4637367B2/ja
Priority to HU0200465A priority patent/HU228588B1/hu
Priority to CNB008055742A priority patent/CN1158072C/zh
Priority to CA002363038A priority patent/CA2363038C/en
Priority to KR1020017011856A priority patent/KR100729848B1/ko
Priority to CZ20013078A priority patent/CZ301266B6/cs
Priority to JP2000221826A priority patent/JP2001097353A/ja
Publication of ITRM990189A1 publication Critical patent/ITRM990189A1/it
Application granted granted Critical
Publication of IT1305308B1 publication Critical patent/IT1305308B1/it
Priority to IL144957A priority patent/IL144957A/en
Priority to US09/962,605 priority patent/US6485741B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
IT1999RM000189A 1999-03-26 1999-03-26 Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione IT1305308B1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT1999RM000189A IT1305308B1 (it) 1999-03-26 1999-03-26 Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
JP2000607624A JP4637367B2 (ja) 1999-03-26 2000-03-22 Ｌ−カルニチンまたはアルカノイルｌ−カルニチン高含有顆粒剤
ES00917258T ES2197867T3 (es) 1999-03-26 2000-03-22 Producto granulado con alto contenido en l-carnitina o alcanoil l-carnitina particularmente apropiado para la produccion de comprimidos por compresion directa.
PT00917258T PT1171111E (pt) 1999-03-26 2000-03-22 Granulado com teor elevado de l-carnitina ou de uma alcanoil l-carnitina particularmente adequado para a producao de comprimidos por compressao directa
DK00917258T DK1171111T3 (da) 1999-03-26 2000-03-22 Granulat, som har højt indhold af L-carnitin eller et alkanoyl L-carnitin, og som er særlig egnet til fremstilling af tabletter ved direkte presning
DE60002454T DE60002454T2 (de) 1999-03-26 2000-03-22 Granulat mit hohem gehalt an l-carnitine oder einem alkanoyl l-carnitine, insbesondere für die herstellung von direktverpressten tabletten
AU38344/00A AU780413B2 (en) 1999-03-26 2000-03-22 Granulate with high content of L-carnitine or an alkanoyl L-carnitine, particularly suitable for the production of tablets by direct compression
HU0200465A HU228588B1 (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine oe an alkanoyl l-carnitine, particularly suitable for the production of tablets by direct compression
PCT/IT2000/000097 WO2000057873A2 (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine or an alkanoyl l-carnitine
PL350908A PL207961B1 (pl) 1999-03-26 2000-03-22 Granulat o wysokiej zawartości L-karnityny lub alkanoilo-L-karnityny do wytwarzania tabletek przez bezpośrednie sprasowywanie lub kapsułek
IL14495700A IL144957A0 (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine or an alkanoyl l-carnitine, particularly suitable for the production of tablets by direct compression
SK1159-2001A SK285565B6 (sk) 1999-03-26 2000-03-22 Granulovaný výrobok s obsahom L-karnitínu, tablety a kapsuly s obsahom tohto výrobku
AT00917258T ATE238784T1 (de) 1999-03-26 2000-03-22 Granulat mit hohem gehalt an l-carnitine oder einem alkanoyl l-carnitine, insbesondere für die herstellung von direktverpressten tabletten
SI200030128T SI1171111T1 (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine or an alkanoyl l-carnitine, particularly suitable for the production of tablets by direct compression
TR2001/02802T TR200102802T2 (tr) 1999-03-26 2000-03-22 Tabletlerin direk kompresyonla üretiminde, yüksek L-karnitin-alkanoil L-karnitinli granülat
CNB008055742A CN1158072C (zh) 1999-03-26 2000-03-22 特别适合于直接压片制备片剂的具有高含量l-肉碱或烷酰基l-肉碱的颗粒
CA002363038A CA2363038C (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine or an alkanoyl l-carnitine, particularly suitable for the production of tablets by direct compression
KR1020017011856A KR100729848B1 (ko) 1999-03-26 2000-03-22 직접 압착에 의한 정제의 제조에 적합한, 고 함량의ｌ-카르니틴 또는 알카노일 ｌ-카르니틴 함유 과립
CZ20013078A CZ301266B6 (cs) 1999-03-26 2000-03-22 Granulát s vysokým obsahem L-karnitinu nebo alkanoyl-L-karnitinu
EP00917258A EP1171111B1 (en) 1999-03-26 2000-03-22 Granulate with high content of l-carnitine or an alkanoyl l-carnitine, particularly suitable for the production of tablets by direct compression
JP2000221826A JP2001097353A (ja) 1999-03-26 2000-07-24 菓子製品およびパッケージ
IL144957A IL144957A (en) 1999-03-26 2001-08-16 Granules with a high content of L-carnitine or L-carnitine alkanol, especially suitable for the production of tablets by direct compression
US09/962,605 US6485741B2 (en) 1999-03-26 2001-09-26 Granulate with high content of L-carnitine or an alkanoyl L-carnitine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999RM000189A IT1305308B1 (it) 1999-03-26 1999-03-26 Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione

Publications (2)

Publication Number Publication Date
ITRM990189A1 ITRM990189A1 (it) 2000-09-26
IT1305308B1 true IT1305308B1 (it) 2001-05-04

Family

ID=11406608

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999RM000189A IT1305308B1 (it) 1999-03-26 1999-03-26 Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione

Country Status (20)

Country Link
US (1) US6485741B2 (it)
EP (1) EP1171111B1 (it)
JP (2) JP4637367B2 (it)
KR (1) KR100729848B1 (it)
CN (1) CN1158072C (it)
AT (1) ATE238784T1 (it)
AU (1) AU780413B2 (it)
CA (1) CA2363038C (it)
CZ (1) CZ301266B6 (it)
DE (1) DE60002454T2 (it)
DK (1) DK1171111T3 (it)
ES (1) ES2197867T3 (it)
HU (1) HU228588B1 (it)
IL (2) IL144957A0 (it)
IT (1) IT1305308B1 (it)
PL (1) PL207961B1 (it)
PT (1) PT1171111E (it)
SK (1) SK285565B6 (it)
TR (1) TR200102802T2 (it)
WO (1) WO2000057873A2 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1218001B1 (en) * 1999-09-03 2008-12-31 Sigma-Tau Healthscience S.p.A. Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
CN1686089B (zh) * 2005-05-08 2010-08-18 北京健健康康生物技术有限公司 一种可直接压片的木糖醇颗粒及其制备方法
BRPI0612611A2 (pt) * 2005-07-05 2010-12-07 Lonza Ag processo de secagem por pulverização para produzir um pó ou granulado seco de carnitina
MX342962B (es) * 2009-09-18 2016-06-07 Teva Pharmaceuticals Holdings Mexico S A De C V Composicion farmaceutica para bajar de peso y procedimiento para obtener la misma.
EP2335495A1 (en) 2009-12-11 2011-06-22 Lonza Ltd. Carnitine granulate and methods for its production
CN102349881B (zh) * 2011-10-26 2013-06-26 东北制药（沈阳）科技发展有限公司 一种左卡尼汀薄膜衣片及其制备方法
CN105695398A (zh) * 2016-04-25 2016-06-22 广西大学 含o-乙酰基-l-肉碱盐酸盐的水牛卵母细胞体外成熟液及培养方法
JP7366612B2 (ja) * 2019-07-09 2023-10-23 東和薬品株式会社 レボカルニチンを含有する錠剤
WO2021228788A1 (en) 2020-05-15 2021-11-18 Alfasigma S.P.A. Composition comprising methylfolate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2921852A1 (de) * 1979-05-29 1980-12-11 Fresenius Chem Pharm Ind Lipide senkendes mittel
IT1119853B (it) * 1979-09-21 1986-03-10 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente l-carnitina per il trattamento delle dislipidemie ed iperlipo proteinemie
JPS59222412A (ja) * 1983-06-01 1984-12-14 Earth Chem Corp Ltd 心臓疾患治療薬
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
IT1181682B (it) * 1985-06-11 1987-09-30 Sigma Tau Ind Farmaceuti Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto
IT1190370B (it) * 1985-06-19 1988-02-16 Zambon Spa Composizione farmaceutica solida per uso orale
JPH03120211A (ja) * 1989-10-04 1991-05-22 Earth Chem Corp Ltd 粒状カルニチン製剤
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
JPH0656659A (ja) * 1992-06-10 1994-03-01 Natl Sci Council 直接打錠できる薬学組成物及びその錠剤の製造法
EP0681839A3 (en) * 1994-05-12 1997-11-12 Hirohiko Kuratsune A pharmaceutical preparation comprising an acylcarnitine
JPH0812569A (ja) * 1994-06-24 1996-01-16 Takeda Chem Ind Ltd 塩化カルニチン吸着固形物
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
DE19629753A1 (de) * 1996-07-23 1998-01-29 Basf Ag Verfahren zur Herstellung von festen Arzneiformen
IT1291126B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti sali non igroscopici della l-carnitina e delle alcanoil l-carnitine
IT1291133B1 (it) * 1997-04-07 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio tartrato
IT1290600B1 (it) * 1997-04-30 1998-12-10 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina e alcanoil l-carnitine magnesio fumarato

Also Published As

Publication number Publication date
DE60002454T2 (de) 2004-03-18
CZ301266B6 (cs) 2009-12-23
JP2001097353A (ja) 2001-04-10
CA2363038A1 (en) 2000-10-05
ITRM990189A1 (it) 2000-09-26
ES2197867T3 (es) 2004-01-16
WO2000057873A3 (en) 2001-04-19
HUP0200465A2 (en) 2002-06-29
IL144957A (en) 2006-08-01
US20020025984A1 (en) 2002-02-28
AU3834400A (en) 2000-10-16
DK1171111T3 (da) 2003-08-25
DE60002454D1 (de) 2003-06-05
KR20010114227A (ko) 2001-12-31
JP4637367B2 (ja) 2011-02-23
TR200102802T2 (tr) 2002-04-22
PT1171111E (pt) 2003-09-30
SK285565B6 (sk) 2007-03-01
EP1171111A2 (en) 2002-01-16
AU780413B2 (en) 2005-03-17
CN1158072C (zh) 2004-07-21
WO2000057873A2 (en) 2000-10-05
ATE238784T1 (de) 2003-05-15
PL350908A1 (en) 2003-02-10
KR100729848B1 (ko) 2007-06-19
US6485741B2 (en) 2002-11-26
SK11592001A3 (sk) 2001-12-03
IL144957A0 (en) 2002-06-30
CA2363038C (en) 2008-10-14
CZ20013078A3 (cs) 2002-02-13
CN1345235A (zh) 2002-04-17
JP2002540153A (ja) 2002-11-26
EP1171111B1 (en) 2003-05-02
PL207961B1 (pl) 2011-02-28
HU228588B1 (en) 2013-04-29

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