ATE426599T1 - Thiazolylpiperidin derivate als mtp inhibitoren - Google Patents
Thiazolylpiperidin derivate als mtp inhibitorenInfo
- Publication number
- ATE426599T1 ATE426599T1 AT04735742T AT04735742T ATE426599T1 AT E426599 T1 ATE426599 T1 AT E426599T1 AT 04735742 T AT04735742 T AT 04735742T AT 04735742 T AT04735742 T AT 04735742T AT E426599 T1 ATE426599 T1 AT E426599T1
- Authority
- AT
- Austria
- Prior art keywords
- mtp inhibitors
- thiazolylpiperidine derivatives
- thiazolylpiperidine
- derivatives
- mtp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0307670A FR2856685B1 (fr) | 2003-06-25 | 2003-06-25 | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE426599T1 true ATE426599T1 (de) | 2009-04-15 |
Family
ID=33515396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04735742T ATE426599T1 (de) | 2003-06-25 | 2004-06-02 | Thiazolylpiperidin derivate als mtp inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7674803B2 (de) |
| EP (1) | EP1636218B1 (de) |
| JP (1) | JP4629666B2 (de) |
| KR (1) | KR20060024812A (de) |
| CN (1) | CN1809560A (de) |
| AR (1) | AR044909A1 (de) |
| AT (1) | ATE426599T1 (de) |
| AU (1) | AU2004253649B2 (de) |
| BR (1) | BRPI0411721A (de) |
| CA (1) | CA2531011C (de) |
| DE (1) | DE602004020223D1 (de) |
| ES (1) | ES2323463T3 (de) |
| FR (1) | FR2856685B1 (de) |
| MX (1) | MXPA05013521A (de) |
| RU (1) | RU2006101890A (de) |
| TW (1) | TW200518751A (de) |
| WO (1) | WO2005003128A1 (de) |
| ZA (1) | ZA200600690B (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2865733B1 (fr) * | 2004-02-04 | 2007-10-12 | Merck Sante Sas | Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine |
| MX2007003115A (es) * | 2004-09-20 | 2007-07-16 | 4Sc Ag | Novedosos inhibidores heterociclicos del nf-kb. |
| EP1637529A1 (de) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Neue Piperidin-4-yl-Thiazol-Carboxamid-Analog als Inhibitoren für die Vermehrung von T-Zellen und ihre Verwendung |
| US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| US20100267717A1 (en) * | 2005-07-29 | 2010-10-21 | 4Sc Ag | Novel Heterocyclic NF-kB Inhibitors |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| WO2007016979A2 (en) * | 2005-07-29 | 2007-02-15 | 4Sc Ag | NOVEL HETEROCYCLIC NF-κB INHIBITORS |
| KR100962827B1 (ko) | 2005-08-18 | 2010-06-10 | 에프. 호프만-라 로슈 아게 | Ｈ3 수용체 조절제로서 유용한 티아졸릴 피페리딘 유도체 |
| EP1832586A1 (de) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazolpiperidinderivate zur Behandlung von Erkrankungen der Leber und des Pankreas |
| CA2646223A1 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| EP1834954A1 (de) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazole als NF-kB Hemmer (Proteasom-Hemmer) |
| WO2007115805A2 (en) * | 2006-04-05 | 2007-10-18 | European Molecular Biology Laboratory (Embl) | Aurora kinase inhibitors |
| KR20090004976A (ko) * | 2006-04-19 | 2009-01-12 | 아스테라스 세이야쿠 가부시키가이샤 | 아졸카르복사미드 유도체 |
| EP2043655A2 (de) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purin- und deazapurin-derivate als pharmazeutische verbindungen |
| WO2008013622A2 (en) | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| WO2008054749A1 (en) * | 2006-10-31 | 2008-05-08 | Schering Corporation | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
| JP5063700B2 (ja) * | 2006-10-31 | 2012-10-31 | シェーリング コーポレイション | アニリノピペラジン誘導体およびアニリノピペラジン誘導体を使用する方法 |
| JP5498168B2 (ja) * | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
| ES2531256T3 (es) | 2007-01-25 | 2015-03-12 | Du Pont | Amidas fungicidas |
| DE102007047735A1 (de) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Thiazolderivate |
| RS53552B1 (en) | 2007-10-11 | 2015-02-27 | Astrazeneca Ab | DERIVATI PIROLO [2,3-D] PIRIMIDINA KAO INHIBITORI PROTEIN KINAZE B |
| TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| BRPI0818201B8 (pt) | 2007-10-24 | 2021-05-25 | Astellas Pharma Inc | composto de azolcarboxamida ou sal do mesmo e uso do mesmo para o tratamento de frequência urinária, urgência urinária, incontinência urinária e dores do trato urinário inferior associadas com várias doenças do trato urinário inferior, e várias doenças acompanhadas de dor |
| CA2703978A1 (en) * | 2007-10-29 | 2009-05-07 | Schering Corporation | Thiazole derivatives as protein kinase inhibitors |
| BRPI0905759A2 (pt) | 2008-01-25 | 2015-07-14 | Du Pont | Composto selecionado a partir dos compostos de fórmula 1 e n óxidos e sais dos mesmos, método para controlar doenças de planta causadas por patógenos de planta fúngicos oomycota e composição fungicida |
| JP5592350B2 (ja) | 2008-04-30 | 2014-09-17 | バイエル・クロップサイエンス・アーゲー | 作物保護剤としてのチアゾール−４−カルボン酸エステル及びチオエステル |
| WO2010037479A1 (de) * | 2008-10-01 | 2010-04-08 | Bayer Cropscience Ag | Heterocyclyl substituierte thiazole als pflanzenschutzmittel |
| JP5592894B2 (ja) | 2008-12-02 | 2014-09-17 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 殺真菌性複素環化合物 |
| JP5642661B2 (ja) * | 2009-03-05 | 2014-12-17 | 塩野義製薬株式会社 | Ｎｐｙｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
| EP2272846A1 (de) * | 2009-06-23 | 2011-01-12 | Bayer CropScience AG | Thiazolylpiperidin Derivate als Fungizide |
| EP2464643A1 (de) * | 2009-08-12 | 2012-06-20 | Syngenta Participations AG | Mikrobiozide heterocyclen |
| WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
| EP2493886B1 (de) | 2009-10-30 | 2014-11-26 | Bayer CropScience AG | Heteroarylpiperidin und -piperazin derivate |
| CN102666532A (zh) * | 2009-12-22 | 2012-09-12 | 先正达参股股份有限公司 | 吡唑衍生物 |
| WO2011134969A1 (de) * | 2010-04-28 | 2011-11-03 | Bayer Cropscience Ag | Ketoheteroarylpiperidin und -piperazin derivate als fungizide |
| WO2011140425A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| US8815775B2 (en) * | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
| CN103492380A (zh) | 2011-02-01 | 2014-01-01 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
| AU2012212196B2 (en) | 2011-02-02 | 2016-10-13 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
| EP2673272A1 (de) * | 2011-02-10 | 2013-12-18 | Syngenta Participations AG | Mikrobiozide pyrazolderivate |
| JP5940562B2 (ja) * | 2011-02-18 | 2016-06-29 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド |
| CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
| PT2694056T (pt) | 2011-04-01 | 2019-11-20 | Astrazeneca Ab | Tratamento terapêutico |
| AU2012321110B2 (en) | 2011-11-30 | 2014-10-23 | Astrazeneca Ab | Combination treatment |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2015018027A1 (en) * | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| EP3573619A4 (de) * | 2017-01-27 | 2020-10-28 | SignalRX Pharmaceuticals, Inc. | Thienopyranone und furanopyranone als kinase-, bromodomänen- und checkpoint-inhibitoren |
| WO2018201069A1 (en) * | 2017-04-28 | 2018-11-01 | Texas Children's Hospital | Targeting nanoparticles |
| CN111196805A (zh) * | 2018-11-17 | 2020-05-26 | 曲阜德禄生物科技有限公司 | 哌啶基噻唑甲酰胺类化合物合成方法与用途 |
| AU2021270664B2 (en) * | 2020-05-12 | 2024-05-30 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of NMDA receptor, and pharmaceutical composition and use thereof |
| WO2024155864A1 (en) * | 2023-01-20 | 2024-07-25 | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. | Sprk1 inhibitors and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
| US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| AU6382701A (en) * | 2000-04-04 | 2001-10-15 | Smithkline Beecham Plc | 2-hydroxy-mutilin carbamate derivatives for antibacterial use |
| FR2816940A1 (fr) | 2000-11-23 | 2002-05-24 | Lipha | Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation |
| GB0129013D0 (en) * | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
| GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
-
2003
- 2003-06-25 FR FR0307670A patent/FR2856685B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-02 JP JP2006515818A patent/JP4629666B2/ja not_active Expired - Fee Related
- 2004-06-02 MX MXPA05013521A patent/MXPA05013521A/es unknown
- 2004-06-02 RU RU2006101890/04A patent/RU2006101890A/ru unknown
- 2004-06-02 US US10/561,989 patent/US7674803B2/en not_active Expired - Fee Related
- 2004-06-02 EP EP04735742A patent/EP1636218B1/de not_active Expired - Lifetime
- 2004-06-02 ES ES04735742T patent/ES2323463T3/es not_active Expired - Lifetime
- 2004-06-02 AU AU2004253649A patent/AU2004253649B2/en not_active Ceased
- 2004-06-02 KR KR1020057024663A patent/KR20060024812A/ko not_active Application Discontinuation
- 2004-06-02 DE DE602004020223T patent/DE602004020223D1/de not_active Expired - Lifetime
- 2004-06-02 CA CA2531011A patent/CA2531011C/en not_active Expired - Fee Related
- 2004-06-02 CN CNA2004800157394A patent/CN1809560A/zh active Pending
- 2004-06-02 WO PCT/EP2004/005931 patent/WO2005003128A1/en active Application Filing
- 2004-06-02 AT AT04735742T patent/ATE426599T1/de not_active IP Right Cessation
- 2004-06-02 BR BRPI0411721-2A patent/BRPI0411721A/pt not_active IP Right Cessation
- 2004-06-21 TW TW093117985A patent/TW200518751A/zh unknown
- 2004-06-25 AR ARP040102230A patent/AR044909A1/es unknown
-
2006
- 2006-01-24 ZA ZA200600690A patent/ZA200600690B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2531011A1 (en) | 2005-01-13 |
| JP2007506651A (ja) | 2007-03-22 |
| ES2323463T3 (es) | 2009-07-16 |
| BRPI0411721A (pt) | 2006-05-23 |
| RU2006101890A (ru) | 2007-07-27 |
| JP4629666B2 (ja) | 2011-02-09 |
| US20070054939A1 (en) | 2007-03-08 |
| CN1809560A (zh) | 2006-07-26 |
| KR20060024812A (ko) | 2006-03-17 |
| FR2856685A1 (fr) | 2004-12-31 |
| DE602004020223D1 (de) | 2009-05-07 |
| WO2005003128A1 (en) | 2005-01-13 |
| EP1636218B1 (de) | 2009-03-25 |
| CA2531011C (en) | 2012-10-09 |
| MXPA05013521A (es) | 2006-03-09 |
| AU2004253649B2 (en) | 2009-09-24 |
| US7674803B2 (en) | 2010-03-09 |
| ZA200600690B (en) | 2007-05-30 |
| FR2856685B1 (fr) | 2005-09-23 |
| AU2004253649A1 (en) | 2005-01-13 |
| AR044909A1 (es) | 2005-10-05 |
| EP1636218A1 (de) | 2006-03-22 |
| TW200518751A (en) | 2005-06-16 |
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