ATE407696T1 - Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoff - Google Patents
Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoffInfo
- Publication number
- ATE407696T1 ATE407696T1 AT98909796T AT98909796T ATE407696T1 AT E407696 T1 ATE407696 T1 AT E407696T1 AT 98909796 T AT98909796 T AT 98909796T AT 98909796 T AT98909796 T AT 98909796T AT E407696 T1 ATE407696 T1 AT E407696T1
- Authority
- AT
- Austria
- Prior art keywords
- preventive
- cure
- treatment
- active ingredients
- multiple sclerosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6846797 | 1997-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407696T1 true ATE407696T1 (de) | 2008-09-15 |
Family
ID=13374532
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98909796T ATE407696T1 (de) | 1997-03-21 | 1998-03-20 | Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoff |
AT08002163T ATE547119T1 (de) | 1997-03-21 | 1998-03-20 | Präventives oder therapeutisches mittel mit einem il-6-antagonisten als wirkstoff für durch sensibilisierte t-zellen vermittelte erkrankungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08002163T ATE547119T1 (de) | 1997-03-21 | 1998-03-20 | Präventives oder therapeutisches mittel mit einem il-6-antagonisten als wirkstoff für durch sensibilisierte t-zellen vermittelte erkrankungen |
Country Status (11)
Country | Link |
---|---|
US (3) | US9017677B2 (de) |
EP (3) | EP2322216A1 (de) |
JP (1) | JPH10324639A (de) |
KR (1) | KR100838862B1 (de) |
AT (2) | ATE407696T1 (de) |
AU (1) | AU736282B2 (de) |
CA (1) | CA2284271C (de) |
DE (1) | DE69839992D1 (de) |
DK (1) | DK2011514T3 (de) |
ES (2) | ES2312184T3 (de) |
WO (1) | WO1998042377A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE407696T1 (de) | 1997-03-21 | 2008-09-15 | Chugai Pharmaceutical Co Ltd | Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoff |
JP4889187B2 (ja) * | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤 |
WO2002036164A1 (fr) * | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Agent abaissant le taux sanguin de vegf contenant un antagoniste de il-6 en tant que principe actif |
UA80091C2 (en) * | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
US20050118163A1 (en) * | 2002-02-14 | 2005-06-02 | Hidefumi Mizushima | Antibody-containing solution pharmaceuticals |
GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
CA2539061A1 (en) * | 2003-09-22 | 2005-03-31 | Biovation Gmbh & Co. Kg | Use of an antagonist of il-6 for treating il-6-mediated diseases |
US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
AR048210A1 (es) * | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
US8398980B2 (en) * | 2004-03-24 | 2013-03-19 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleuken-6 receptor |
PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
AR058135A1 (es) | 2005-10-21 | 2008-01-23 | Chugai Pharmaceutical Co Ltd | Agentes para el tratamiento de cardiopatias |
AU2006323490B2 (en) * | 2005-12-09 | 2012-05-24 | R-Pharm International Llc | Antibody molecules having specificity for human IL-6 |
CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
MX2009001110A (es) | 2006-08-03 | 2009-05-11 | Vaccinex Inc | Anticuerpos monoclonales anti-il-6 y usos de los mismos. |
US8414897B1 (en) * | 2006-10-02 | 2013-04-09 | The Uab Research Foundation | Pathway for Th-17 cell development and methods utilizing same |
JP2010095445A (ja) * | 2006-12-27 | 2010-04-30 | Tokyo Medical & Dental Univ | Il−6アンタゴニストを有効成分とする炎症性筋疾患治療剤 |
BRPI0806812B8 (pt) | 2007-01-23 | 2021-09-14 | Chugai Pharmaceutical Co Ltd | Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6 |
US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
MX349322B (es) | 2007-05-21 | 2017-07-21 | Alderbio Holdings Llc | Anticuerpos para il-6 y sus usos. |
EP2162469A4 (de) * | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | Neue verfahren zur humanisierung von kaninchenantikörpern und humanisierte kaninchenantikörper |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
US8252286B2 (en) * | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
WO2009014263A1 (ja) * | 2007-07-26 | 2009-01-29 | Osaka University | インターロイキン6受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
MX342551B (es) | 2007-09-26 | 2016-10-04 | Chugai Pharmaceutical Co Ltd | Region constante de anticuerpo modificada. |
EP3127921A1 (de) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstition in cdr |
PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
TR201808535T4 (tr) | 2008-04-11 | 2018-07-23 | Chugai Pharmaceutical Co Ltd | İki veya daha fazla sayıda antijen molekülüne tekrar tekrar bağlanabilen antijen bağlanma molekülü. |
US8034344B2 (en) | 2008-05-13 | 2011-10-11 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
CN102256623A (zh) | 2008-06-05 | 2011-11-23 | 独立行政法人国立癌症研究中心 | 神经浸润抑制剂 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
KR101985153B1 (ko) | 2009-10-26 | 2019-05-31 | 에프. 호프만-라 로슈 아게 | 글리코실화된 면역글로불린의 제조 방법 |
US9724410B2 (en) | 2009-11-24 | 2017-08-08 | Alderbio Holdings Llc | Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
JP6051049B2 (ja) | 2010-05-28 | 2016-12-21 | 中外製薬株式会社 | 抗腫瘍t細胞応答増強剤 |
US20130149302A1 (en) | 2010-05-28 | 2013-06-13 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for pancreatic cancer |
KR101372721B1 (ko) | 2010-06-18 | 2014-03-14 | 이화여자대학교 산학협력단 | Interleukin―6 억제 작용을 갖는 신규한 벤즈옥사졸 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
KR20130086628A (ko) | 2010-11-08 | 2013-08-02 | 제넨테크, 인크. | 피하 투여용 항―il―6 수용체 항체 |
CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
US20140234340A1 (en) | 2010-11-30 | 2014-08-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
JP4987117B2 (ja) * | 2010-12-27 | 2012-07-25 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤 |
JP6117915B2 (ja) | 2012-05-21 | 2017-04-19 | コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジーKorea Research Institute Of Bioscience And Biotechnology | ミゾコウジュの抽出物またはその分画物を有効成分として含む、stat3媒介性疾患の予防または治療用医薬組成物 |
JP6442404B2 (ja) * | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
JP6563910B2 (ja) | 2013-07-04 | 2019-08-21 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ |
SG11201705093UA (en) | 2015-02-27 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Composition for treating il-6-related diseases |
PL3299810T3 (pl) | 2015-05-19 | 2021-12-13 | National Center Of Neurology And Psychiatry | Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm) |
US11174317B2 (en) | 2015-06-04 | 2021-11-16 | National Center Of Neurology And Psychiatry | Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient |
US11484591B2 (en) | 2016-02-22 | 2022-11-01 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites |
CN110603057A (zh) | 2017-03-17 | 2019-12-20 | 俄亥俄州创新基金会 | 用于递送化学预防剂的纳米颗粒 |
EP3620531A4 (de) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | Verfahren zur vorhersage und beurteilung der therapeutischen wirkung bei erkrankungen im zusammenhang mit il-6 und neutrophilen |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
WO2019175332A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity |
EP3947737A2 (de) | 2019-04-02 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur vorhersage und vorbeugung von krebs bei patienten mit prämalignen läsionen |
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-
1998
- 1998-03-20 AT AT98909796T patent/ATE407696T1/de not_active IP Right Cessation
- 1998-03-20 KR KR1019997008666A patent/KR100838862B1/ko not_active IP Right Cessation
- 1998-03-20 JP JP10072449A patent/JPH10324639A/ja active Pending
- 1998-03-20 DE DE69839992T patent/DE69839992D1/de not_active Expired - Lifetime
- 1998-03-20 DK DK08002163.7T patent/DK2011514T3/da active
- 1998-03-20 ES ES98909796T patent/ES2312184T3/es not_active Expired - Lifetime
- 1998-03-20 EP EP10179343A patent/EP2322216A1/de not_active Withdrawn
- 1998-03-20 CA CA2284271A patent/CA2284271C/en not_active Expired - Fee Related
- 1998-03-20 EP EP98909796A patent/EP0983767B1/de not_active Expired - Lifetime
- 1998-03-20 ES ES08002163T patent/ES2382488T3/es not_active Expired - Lifetime
- 1998-03-20 AU AU64207/98A patent/AU736282B2/en not_active Ceased
- 1998-03-20 EP EP08002163A patent/EP2011514B1/de not_active Revoked
- 1998-03-20 AT AT08002163T patent/ATE547119T1/de active
- 1998-03-20 WO PCT/JP1998/001217 patent/WO1998042377A1/ja active IP Right Grant
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2006
- 2006-01-25 US US11/340,412 patent/US9017677B2/en not_active Expired - Fee Related
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- 2015-03-18 US US14/662,139 patent/US20150191540A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
US20150191540A1 (en) | 2015-07-09 |
EP2011514A1 (de) | 2009-01-07 |
US20170022278A1 (en) | 2017-01-26 |
EP0983767B1 (de) | 2008-09-10 |
KR20010005602A (ko) | 2001-01-15 |
US20060134113A1 (en) | 2006-06-22 |
DE69839992D1 (de) | 2008-10-23 |
DK2011514T3 (da) | 2012-03-26 |
US9017677B2 (en) | 2015-04-28 |
KR100838862B1 (ko) | 2008-06-16 |
ATE547119T1 (de) | 2012-03-15 |
CA2284271C (en) | 2012-05-08 |
ES2312184T3 (es) | 2009-02-16 |
ES2382488T3 (es) | 2012-06-08 |
EP2322216A1 (de) | 2011-05-18 |
EP2011514B1 (de) | 2012-02-29 |
CA2284271A1 (en) | 1998-10-01 |
WO1998042377A1 (en) | 1998-10-01 |
AU6420798A (en) | 1998-10-20 |
EP0983767A1 (de) | 2000-03-08 |
EP0983767A4 (de) | 2001-03-28 |
JPH10324639A (ja) | 1998-12-08 |
AU736282B2 (en) | 2001-07-26 |
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