|
US8017121B2
(en)
*
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
|
CZ296979B6
(cs)
*
|
1994-10-21 |
2006-08-16 |
Chugai Seiyaku Kabushiki Kaisha |
Farmaceutický prípravek pro prevenci nebo lécení Castlemanovy nemoci
|
|
ATE407696T1
(de)
|
1997-03-21 |
2008-09-15 |
Chugai Pharmaceutical Co Ltd |
Vorbeugende- oder heilmittel zur behandlung von multipler sklerose, mit antagonistischen anti-il6-rezeptor antikörpern als wirkstoff
|
|
US20020187150A1
(en)
*
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
|
CN100374159C
(zh)
*
|
1998-03-17 |
2008-03-12 |
中外制药株式会社 |
一种包含il-6拮抗剂活性成分的炎性肠道疾病的预防或治疗剂
|
|
AU775483B2
(en)
*
|
1998-06-10 |
2004-08-05 |
Promega Corporation |
Antibodies to cytokines in the prevention and treatment of inflammatory bowel disease
|
|
JP4889187B2
(ja)
*
|
2000-10-27 |
2012-03-07 |
中外製薬株式会社 |
Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤
|
|
UA80091C2
(en)
*
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
US20050118163A1
(en)
*
|
2002-02-14 |
2005-06-02 |
Hidefumi Mizushima |
Antibody-containing solution pharmaceuticals
|
|
CN1678744B
(zh)
*
|
2002-08-30 |
2010-05-26 |
财团法人化学及血清疗法研究所 |
人的抗人白细胞介素-6抗体以及所述抗体的片段
|
|
GB2401040A
(en)
*
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
CA2539061A1
(en)
*
|
2003-09-22 |
2005-03-31 |
Biovation Gmbh & Co. Kg |
Use of an antagonist of il-6 for treating il-6-mediated diseases
|
|
WO2005037315A1
(ja)
*
|
2003-10-17 |
2005-04-28 |
Chugai Seiyaku Kabushiki Kaisha |
中皮腫治療剤
|
|
US8617550B2
(en)
*
|
2003-12-19 |
2013-12-31 |
Chugai Seiyaku Kabushiki Kaisha |
Treatment of vasculitis with IL-6 antagonist
|
|
US8398980B2
(en)
*
|
2004-03-24 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleuken-6 receptor
|
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
|
AU2006232287B2
(en)
|
2005-03-31 |
2011-10-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing polypeptides by regulating polypeptide association
|
|
US8470316B2
(en)
|
2005-10-14 |
2013-06-25 |
Chugai Seiyaku Kabushiki Kaisha |
Agents for suppressing damage to transplanted islets after islet transplantation
|
|
AR058135A1
(es)
|
2005-10-21 |
2008-01-23 |
Chugai Pharmaceutical Co Ltd |
Agentes para el tratamiento de cardiopatias
|
|
AR057582A1
(es)
*
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
JPWO2007061029A1
(ja)
*
|
2005-11-25 |
2009-05-07 |
学校法人慶應義塾 |
前立腺癌治療剤
|
|
ES2685915T3
(es)
|
2006-01-27 |
2018-10-15 |
Keio University |
Agentes terapéuticos para enfermedades que implican neovascularización coroidea
|
|
DK2009101T3
(da)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antistofmodifikationsfremgangsmåde til oprensning af et bispecifikt antistof
|
|
CA2647846C
(en)
|
2006-03-31 |
2016-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for controlling blood pharmacokinetics of antibodies
|
|
JP5754875B2
(ja)
|
2006-04-07 |
2015-07-29 |
国立大学法人大阪大学 |
筋再生促進剤
|
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
|
EP2374818B1
(en)
|
2006-06-02 |
2012-12-19 |
Regeneron Pharmaceuticals, Inc. |
High affinity antibodies to human IL-6 receptor
|
|
MX2009001110A
(es)
|
2006-08-03 |
2009-05-11 |
Vaccinex Inc |
Anticuerpos monoclonales anti-il-6 y usos de los mismos.
|
|
CN101528778A
(zh)
*
|
2006-08-18 |
2009-09-09 |
埃博灵克斯股份有限公司 |
用于治疗与il-6-介导的信号传导相关的疾病和病症的针对il-6r的氨基酸序列以及包括其的多肽
|
|
CA2670583A1
(en)
*
|
2006-11-30 |
2008-06-05 |
Medimmune, Llc |
Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor
|
|
JP2010095445A
(ja)
*
|
2006-12-27 |
2010-04-30 |
Tokyo Medical & Dental Univ |
Ｉｌ−６アンタゴニストを有効成分とする炎症性筋疾患治療剤
|
|
BRPI0806812B8
(pt)
|
2007-01-23 |
2021-09-14 |
Chugai Pharmaceutical Co Ltd |
Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6
|
|
US8053440B2
(en)
|
2007-02-01 |
2011-11-08 |
Resverlogix Corporation |
Compounds for the prevention and treatment of cardiovascular diseases
|
|
EP2162469A4
(en)
*
|
2007-05-21 |
2012-08-01 |
Alderbio Holdings Llc |
NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
US7906117B2
(en)
*
|
2007-05-21 |
2011-03-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
|
|
US20090238825A1
(en)
*
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
US8178101B2
(en)
|
2007-05-21 |
2012-05-15 |
Alderbio Holdings Inc. |
Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
|
|
MX349322B
(es)
|
2007-05-21 |
2017-07-21 |
Alderbio Holdings Llc |
Anticuerpos para il-6 y sus usos.
|
|
US9701747B2
(en)
|
2007-05-21 |
2017-07-11 |
Alderbio Holdings Llc |
Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
|
|
US8252286B2
(en)
*
|
2007-05-21 |
2012-08-28 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8404235B2
(en)
|
2007-05-21 |
2013-03-26 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
CN101939425B
(zh)
*
|
2007-09-26 |
2014-05-14 |
中外制药株式会社 |
抗il-6受体抗体
|
|
EP3127921A1
(en)
|
2007-09-26 |
2017-02-08 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substition in cdr
|
|
MX342551B
(es)
|
2007-09-26 |
2016-10-04 |
Chugai Pharmaceutical Co Ltd |
Region constante de anticuerpo modificada.
|
|
BRPI0821110B8
(pt)
*
|
2007-12-05 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
TR201808535T4
(tr)
*
|
2008-04-11 |
2018-07-23 |
Chugai Pharmaceutical Co Ltd |
İki veya daha fazla sayıda antijen molekülüne tekrar tekrar bağlanabilen antijen bağlanma molekülü.
|
|
US8034344B2
(en)
|
2008-05-13 |
2011-10-11 |
Novimmune S.A. |
Anti-IL-6/IL-6R antibodies and methods of use thereof
|
|
CN102256623A
(zh)
*
|
2008-06-05 |
2011-11-23 |
独立行政法人国立癌症研究中心 |
神经浸润抑制剂
|
|
US8188235B2
(en)
|
2008-06-18 |
2012-05-29 |
Pfizer Inc. |
Antibodies to IL-6 and their uses
|
|
TWI440469B
(zh)
*
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
US8323649B2
(en)
*
|
2008-11-25 |
2012-12-04 |
Alderbio Holdings Llc |
Antibodies to IL-6 and use thereof
|
|
US9212223B2
(en)
|
2008-11-25 |
2015-12-15 |
Alderbio Holdings Llc |
Antagonists of IL-6 to prevent or treat thrombosis
|
|
US8337847B2
(en)
|
2008-11-25 |
2012-12-25 |
Alderbio Holdings Llc |
Methods of treating anemia using anti-IL-6 antibodies
|
|
US8992920B2
(en)
|
2008-11-25 |
2015-03-31 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies for the treatment of arthritis
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
US9452227B2
(en)
*
|
2008-11-25 |
2016-09-27 |
Alderbio Holdings Llc |
Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
|
|
US20120034212A1
(en)
*
|
2009-01-29 |
2012-02-09 |
Michael Bowen |
Human Anti-IL-6 Antibodies With Extended In Vivo Half-Life And Their Use In Treatment Of Oncology, Autoimmune Diseases And Inflammatory Diseases
|
|
NZ708314A
(en)
|
2009-03-18 |
2017-08-25 |
Resverlogix Corp |
Quinazolinones for use as anticancer agents
|
|
TWI682995B
(zh)
|
2009-03-19 |
2020-01-21 |
日商中外製藥股份有限公司 |
抗體恆定區域改變體
|
|
EP2409991B1
(en)
|
2009-03-19 |
2017-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
PL2421533T3
(pl)
|
2009-04-22 |
2019-05-31 |
Resverlogix Corp |
Nowe środki przeciwzapalne
|
|
SG176074A1
(en)
|
2009-05-15 |
2011-12-29 |
Chugai Pharmaceutical Co Ltd |
Anti-axl antibody
|
|
WO2011037158A1
(ja)
|
2009-09-24 |
2011-03-31 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
JO3244B1
(ar)
*
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
KR101985153B1
(ko)
|
2009-10-26 |
2019-05-31 |
에프. 호프만-라 로슈 아게 |
글리코실화된 면역글로불린의 제조 방법
|
|
US9724410B2
(en)
|
2009-11-24 |
2017-08-08 |
Alderbio Holdings Llc |
Anti-IL-6 antibodies or fragments thereof to treat or inhibit cachexia, associated with chemotherapy toxicity
|
|
US9775921B2
(en)
|
2009-11-24 |
2017-10-03 |
Alderbio Holdings Llc |
Subcutaneously administrable composition containing anti-IL-6 antibody
|
|
JO3417B1
(ar)
|
2010-01-08 |
2019-10-20 |
Regeneron Pharma |
الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
|
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
US20130149302A1
(en)
|
2010-05-28 |
2013-06-13 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for pancreatic cancer
|
|
JP6051049B2
(ja)
|
2010-05-28 |
2016-12-21 |
中外製薬株式会社 |
抗腫瘍ｔ細胞応答増強剤
|
|
KR20130086628A
(ko)
|
2010-11-08 |
2013-08-02 |
제넨테크, 인크. |
피하 투여용 항―ｉｌ―6 수용체 항체
|
|
CA2818813C
(en)
|
2010-11-23 |
2020-10-06 |
Alder Biopharmaceuticals, Inc. |
Anti-il-6 antibodies for the treatment of oral mucositis
|
|
US20140234340A1
(en)
|
2010-11-30 |
2014-08-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
EP3395836B1
(en)
|
2011-01-28 |
2021-04-28 |
Sanofi Biotechnology |
Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
|
|
EP2520292A1
(en)
|
2011-05-06 |
2012-11-07 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated disorders
|
|
MD480Z
(en)
*
|
2011-07-07 |
2012-09-30 |
Elvira Andon |
Method for treating acute ulcerative nonspecific colitis
|
|
AR087305A1
(es)
|
2011-07-28 |
2014-03-12 |
Regeneron Pharma |
Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
|
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
|
US9402898B2
(en)
|
2012-01-23 |
2016-08-02 |
Regeneron Pharmaceuticals, Inc. |
Stabilized formulations containing anti-Ang2 antibodies
|
|
JP6117915B2
(ja)
|
2012-05-21 |
2017-04-19 |
コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｂｉｏｓｃｉｅｎｃｅ Ａｎｄ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ |
ミゾコウジュの抽出物またはその分画物を有効成分として含む、ｓｔａｔ３媒介性疾患の予防または治療用医薬組成物
|
|
US10822420B2
(en)
*
|
2012-09-13 |
2020-11-03 |
Chugai Seiyaku Kabushiki Kaisha |
Gene knock-in non-human animal
|
|
JP6442404B2
(ja)
|
2013-06-11 |
2018-12-19 |
国立研究開発法人国立精神・神経医療研究センター |
再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法
|
|
JP6563910B2
(ja)
|
2013-07-04 |
2019-08-21 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
|
|
WO2015046467A1
(ja)
|
2013-09-27 |
2015-04-02 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
DE202014010499U1
(de)
|
2013-12-17 |
2015-10-20 |
Kymab Limited |
Targeting von humaner PCSK9 zur Cholesterinbehandlung
|
|
US9017678B1
(en)
|
2014-07-15 |
2015-04-28 |
Kymab Limited |
Method of treating rheumatoid arthritis using antibody to IL6R
|
|
WO2015116852A1
(en)
|
2014-01-29 |
2015-08-06 |
Regeneron Pharmaceuticals, Inc. |
Methods for treating rheumatoid arthritis by administering an il-6r antibody
|
|
SG11201705093UA
(en)
|
2015-02-27 |
2017-07-28 |
Chugai Pharmaceutical Co Ltd |
Composition for treating il-6-related diseases
|
|
JO3789B1
(ar)
|
2015-03-13 |
2021-01-31 |
Resverlogix Corp |
التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة
|
|
WO2016159213A1
(ja)
|
2015-04-01 |
2016-10-06 |
中外製薬株式会社 |
ポリペプチド異種多量体の製造方法
|
|
PL3299810T3
(pl)
|
2015-05-19 |
2021-12-13 |
National Center Of Neurology And Psychiatry |
Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm)
|
|
US11174317B2
(en)
|
2015-06-04 |
2021-11-16 |
National Center Of Neurology And Psychiatry |
Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient
|
|
KR20180034672A
(ko)
|
2015-08-18 |
2018-04-04 |
리제너론 파아마슈티컬스, 인크. |
지단백질 분리반출술을 경험하고 있는 고지혈증을 갖는 환자를 치료하기 위한 항-pcsk9 억제성 항체
|
|
AU2016381992B2
(en)
|
2015-12-28 |
2024-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
Method for promoting efficiency of purification of Fc region-containing polypeptide
|
|
US11484591B2
(en)
|
2016-02-22 |
2022-11-01 |
Ohio State Innovation Foundation |
Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
TWI805565B
(zh)
|
2017-01-27 |
2023-06-21 |
日商斯德武利姆股份有限公司 |
心肌病、陳舊性心肌梗塞及慢性心臟衰竭的治療藥物
|
|
EP3576790A4
(en)
|
2017-02-01 |
2020-12-23 |
Yale University |
TREATMENT OF DIURETIC RESISTANCE
|
|
CN110603057A
(zh)
|
2017-03-17 |
2019-12-20 |
俄亥俄州创新基金会 |
用于递送化学预防剂的纳米颗粒
|
|
EP3620531A4
(en)
|
2017-05-02 |
2021-03-17 |
National Center of Neurology and Psychiatry |
METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
|
|
US11692037B2
(en)
|
2017-10-20 |
2023-07-04 |
Hyogo College Of Medicine |
Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
|
|
PE20211196A1
(es)
|
2018-01-05 |
2021-07-01 |
Novo Nordisk As |
Metodos para tratar inflamacion mediada por il-6 sin inmunosupresion
|
|
TW202413402A
(zh)
|
2018-03-15 |
2024-04-01 |
日商中外製藥股份有限公司 |
對茲卡病毒具有交叉反應性的抗登革病毒抗體之用途
|
|
MX2021009242A
(es)
|
2019-01-31 |
2021-10-26 |
Sanofi Biotechnology |
Anticuerpo anti-receptor de il-6 para tratar la artritis juvenil idiopatica.
|
|
EP3947737A2
(en)
|
2019-04-02 |
2022-02-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
JP2023508592A
(ja)
*
|
2019-12-31 |
2023-03-02 |
ペプチノフ |
術後痛を予防又は治療するための医薬組成物
|
|
WO2022047730A1
(en)
*
|
2020-09-04 |
2022-03-10 |
Shanghai Pharmaceuticals Holding Co., Ltd. |
Methods to treat inflammatory bowel disease
|
|
GB202301306D0
(en)
*
|
2023-01-30 |
2023-03-15 |
Ucl Business Ltd |
Treatment of granulomatous disease
|